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UBERON:0002062

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Name:endocardial cushion
Namespace:FANTOM
Definition:"The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Endocardial_cushion, ZFIN:curator]
Xrefs:
links:

EHDAA2:0000434
EHDAA2:0004028
EHDAA:2586
EMAPA:16696
FMA:70302
[ 200px-Gray465.png 200px-Gray465.png]
MA:0000078
TAO:0001317
VHOG:0000932
XAO:0004189

ZFA:0001317
Synonyms: "atrioventricular cushion" EXACT [Wikipedia:Endocardial_cushion]
"cardiac cushion" EXACT [PMID:15797462]
"endocardial cushion tissue" EXACT [EHDAA2:0000434]
"endocardial cushions" RELATED PLURAL []
Comments:GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt
Alt_id: UBERON:FMA_70302-MA_0000078-ZFA_0001317
Subset: uberon_slim
vertebrate_core

Ontology association
Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.

link to ontology dataset
data


Parents

is_a:UBERON:0005256(trunk mesenchyme),UBERON:0009751(cardiac mesenchyme),UBERON:0014387(mesenchyme derived from neural crest)
develops_from:UBERON:0002342(neural crest)
part_of:UBERON:0000922(embryo),UBERON:0000948(heart),UBERON:0002165(endocardium)



Children

develops from:UBERON:0000946 (cardial valve),UBERON:0002133 (atrioventricular valve)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Uberon ontology




Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002062 (endocardial cushion), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
5.41e-147FFCP PHASE1:Hg19::chr7:25815812..25815822,-#_762ae4977c5b9bd324fb358280f418bfp@chr7:25815812..25815822, -
5.41e-147FFCP PHASE2:Hg19::chr7:25815812..25815822,-#_762ae4977c5b9bd324fb358280f418bfp@chr7:25815812..25815822, -
8.98e-131FFCP PHASE1:Hg19::chr12:3373147..3373149,-#_635dfec0fe0be947f436d2464039a74cp@chr12:3373147..3373149, -
8.98e-131FFCP PHASE2:Hg19::chr12:3373147..3373149,-#_635dfec0fe0be947f436d2464039a74cp@chr12:3373147..3373149, -
7.78e-118FFCP PHASE1:Hg19::chr1:20355975..20355980,-#_9d4ffbe77040424cb79c5ff4438cf931p@chr1:20355975..20355980, -
7.78e-118FFCP PHASE2:Hg19::chr1:20355975..20355980,-#_9d4ffbe77040424cb79c5ff4438cf931p@chr1:20355975..20355980, -
5.69e-99FFCP PHASE2:Hg19::chr1:237331032..237331036,+#_835fa8341d0c262fdfd6e0626569968bp@chr1:237331032..237331036, +
5.69e-99FFCP PHASE1:Hg19::chr1:237331032..237331036,+#_835fa8341d0c262fdfd6e0626569968bp@chr1:237331032..237331036, +
1.52e-87FFCP PHASE1:Hg19::chr2:18116344..18116353,+#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr2:18116344..18116353, +
1.52e-87FFCP PHASE2:Hg19::chr6:6739548..6739577,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr6:6739548..6739577, -
1.52e-87FFCP PHASE2:Hg19::chr1:11907265..11907271,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p9@NPPA
1.52e-87FFCP PHASE2:Hg19::chr2:18116344..18116353,+#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr2:18116344..18116353, +
1.52e-87FFCP PHASE1:Hg19::chr1:11907265..11907271,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p9@NPPA
1.52e-87FFCP PHASE1:Hg19::chr6:6739548..6739577,-#_614cf3e9e3ccaa6d6992f7bbe160d5e7p@chr6:6739548..6739577, -
7.21e-85FFCP PHASE2:Hg19::chrX:112324334..112324339,-#_1838e9c018ff4fd86f1a9025a8b8f460p@chrX:112324334..112324339, -
7.21e-85FFCP PHASE1:Hg19::chrX:112324334..112324339,-#_1838e9c018ff4fd86f1a9025a8b8f460p@chrX:112324334..112324339, -
1.71e-84FFCP PHASE2:Hg19::chr2:220491902..220491915,+#_b6923c5d443c2311ba1de622c00a817dp11@SLC4A3
1.71e-84FFCP PHASE1:Hg19::chr2:220491902..220491915,+#_b6923c5d443c2311ba1de622c00a817dp11@SLC4A3
2.27e-84FFCP PHASE2:Hg19::chr2:179533457..179533461,-#_3712d16c33f17b194ef04727d80c5105p@chr2:179533457..179533461, -
2.27e-84FFCP PHASE1:Hg19::chr2:179533457..179533461,-#_3712d16c33f17b194ef04727d80c5105p@chr2:179533457..179533461, -
3.03e-84FFCP PHASE1:Hg19::chr2:179398102..179398109,-#_6d355795341c965d833156528609129cp@chr2:179398102..179398109, -
3.03e-84FFCP PHASE2:Hg19::chr2:179398102..179398109,-#_6d355795341c965d833156528609129cp@chr2:179398102..179398109, -
7.81e-75FFCP PHASE1:Hg19::chr5:123739302..123739319,-#_34e1c5ae416c19fc71c6f5e25c3eb0a7p@chr5:123739302..123739319, -
7.81e-75FFCP PHASE2:Hg19::chr5:123739302..123739319,-#_34e1c5ae416c19fc71c6f5e25c3eb0a7p@chr5:123739302..123739319, -
1.01e-74FFCP PHASE2:Hg19::chr18:64271475..64271484,-#_9cf5a366e88a7fe3a00e0a2f8700b81ep6@CDH19
1.01e-74FFCP PHASE1:Hg19::chr18:64271475..64271484,-#_9cf5a366e88a7fe3a00e0a2f8700b81ep6@CDH19
1.29e-74FFCP PHASE1:Hg19::chr7:35286774..35286778,-#_81f4a059026a07aacc21db93a7efefe7p@chr7:35286774..35286778, -
1.29e-74FFCP PHASE2:Hg19::chr7:35286774..35286778,-#_81f4a059026a07aacc21db93a7efefe7p@chr7:35286774..35286778, -
1.66e-74FFCP PHASE2:Hg19::chr6:129355052..129355056,+#_ad0d0bce36c8d290d1ce627c25061ca2p@chr6:129355052..129355056, +
1.66e-74FFCP PHASE1:Hg19::chr6:129355052..129355056,+#_ad0d0bce36c8d290d1ce627c25061ca2p@chr6:129355052..129355056, +
2.75e-74FFCP PHASE2:Hg19::chr3:16940540..16940554,+#_f4cf4c24f5f8a8d9a052066bdba31cb3p@chr3:16940540..16940554, +
2.75e-74FFCP PHASE1:Hg19::chr3:16940540..16940554,+#_f4cf4c24f5f8a8d9a052066bdba31cb3p@chr3:16940540..16940554, +
3.54e-74FFCP PHASE2:Hg19::chr19:55661803..55661807,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr19:55661803..55661807, -
3.54e-74FFCP PHASE2:Hg19::chr3:131523446..131523459,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr3:131523446..131523459, -
3.54e-74FFCP PHASE2:Hg19::chr1:201328779..201328797,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr1:201328779..201328797, -
3.54e-74FFCP PHASE1:Hg19::chr1:201328779..201328797,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr1:201328779..201328797, -
3.54e-74FFCP PHASE1:Hg19::chr3:131523446..131523459,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr3:131523446..131523459, -
3.54e-74FFCP PHASE1:Hg19::chr20:33565465..33565475,+#_2d4de84d93e740177f9bae24c7ae3cafp9@MYH7B
3.54e-74FFCP PHASE2:Hg19::chr20:33565465..33565475,+#_2d4de84d93e740177f9bae24c7ae3cafp9@MYH7B
3.54e-74FFCP PHASE1:Hg19::chr19:55661803..55661807,-#_2d4de84d93e740177f9bae24c7ae3cafp@chr19:55661803..55661807, -
5.84e-74FFCP PHASE2:Hg19::chr6:36812121..36812130,-#_4585aca20afb02706bb3f0ed71ac21d6p@chr6:36812121..36812130, -
5.84e-74FFCP PHASE1:Hg19::chr6:36812121..36812130,-#_4585aca20afb02706bb3f0ed71ac21d6p@chr6:36812121..36812130, -
7.51e-74FFCP PHASE2:Hg19::chr14:105939326..105939337,+#_c6336d4cc8876434a4bcc8abd2610fafp16@CRIP2
7.51e-74FFCP PHASE1:Hg19::chr14:105939326..105939337,+#_c6336d4cc8876434a4bcc8abd2610fafp16@CRIP2
9.64e-74FFCP PHASE2:Hg19::chr1:206838422..206838456,+#_9c84b2e6afc7cd2e0ab422820dbb961bp@chr1:206838422..206838456, +
9.64e-74FFCP PHASE1:Hg19::chr1:206838422..206838456,+#_9c84b2e6afc7cd2e0ab422820dbb961bp@chr1:206838422..206838456, +
1.24e-73FFCP PHASE1:Hg19::chr1:231983543..231983554,-#_f3429bb285901c3571949a3976ea4396p@chr1:231983543..231983554, -
1.24e-73FFCP PHASE2:Hg19::chr1:231983543..231983554,-#_f3429bb285901c3571949a3976ea4396-, p@chr1:231983543..231983554
1.54e-66FFCP PHASE2:Hg19::chr1:201328328..201328343,-#_32adff27e8827c4cf61244dfd8d4515bp@chr1:201328328..201328343, -
1.54e-66FFCP PHASE1:Hg19::chr1:201328328..201328343,-#_32adff27e8827c4cf61244dfd8d4515bp@chr1:201328328..201328343, -
1.71e-66FFCP PHASE2:Hg19::chr1:237214095..237214115,+#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr1:237214095..237214115, +
1.71e-66FFCP PHASE1:Hg19::chr1:237214095..237214115,+#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr1:237214095..237214115, +
1.71e-66FFCP PHASE2:Hg19::chr11:47367243..47367257,-#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr11:47367243..47367257, -
1.71e-66FFCP PHASE1:Hg19::chr11:47367243..47367257,-#_d0c121113f34d1b688fcb2a4a7fdbc5ap@chr11:47367243..47367257, -
2.39e-66FFCP PHASE1:Hg19::chr15:86272097..86272099,+#_320cfe93e3aa96f2b04e0462a6d0a775p@chr15:86272097..86272099, +
2.39e-66FFCP PHASE1:Hg19::chr5:99390735..99390743,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr5:99390735..99390743, -
2.39e-66FFCP PHASE2:Hg19::chr5:99390735..99390743,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr5:99390735..99390743, -
2.39e-66FFCP PHASE2:Hg19::chr10:92678409..92678410,-#_320cfe93e3aa96f2b04e0462a6d0a775-, p@chr10:92678409..92678410
2.39e-66FFCP PHASE2:Hg19::chr15:86272097..86272099,+#_320cfe93e3aa96f2b04e0462a6d0a775p@chr15:86272097..86272099, +
2.39e-66FFCP PHASE1:Hg19::chr10:92678409..92678410,-#_320cfe93e3aa96f2b04e0462a6d0a775p@chr10:92678409..92678410, -
2.4e-66FFCP PHASE2:Hg19::chr12:4735761..4735787,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:4735761..4735787, -
2.4e-66FFCP PHASE1:Hg19::chr1:237996521..237996532,+#_eed72d0370f737c0be448fbbd6c789bap@chr1:237996521..237996532, +
2.4e-66FFCP PHASE1:Hg19::chr12:114886577..114886589,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:114886577..114886589, -
2.4e-66FFCP PHASE2:Hg19::chr2:159976509..159976519,+#_eed72d0370f737c0be448fbbd6c789bap@chr2:159976509..159976519, +
2.4e-66FFCP PHASE2:Hg19::chr1:237996521..237996532,+#_eed72d0370f737c0be448fbbd6c789bap@chr1:237996521..237996532, +
2.4e-66FFCP PHASE1:Hg19::chr12:4735761..4735787,-#_eed72d0370f737c0be448fbbd6c789bap@chr12:4735761..4735787, -
2.4e-66FFCP PHASE2:Hg19::chr12:114886577..114886589,-#_eed72d0370f737c0be448fbbd6c789ba-, p@chr12:114886577..114886589
2.4e-66FFCP PHASE1:Hg19::chr2:159976509..159976519,+#_eed72d0370f737c0be448fbbd6c789bap@chr2:159976509..159976519, +
2.41e-66FFCP PHASE2:Hg19::chr2:40480968..40480972,-#_adc1ad9f0cbb8957437efc6d203881c8p@chr2:40480968..40480972, -
2.41e-66FFCP PHASE2:Hg19::chr1:237207955..237207959,+#_adc1ad9f0cbb8957437efc6d203881c8p@chr1:237207955..237207959, +
2.41e-66FFCP PHASE1:Hg19::chr1:237207955..237207959,+#_adc1ad9f0cbb8957437efc6d203881c8p@chr1:237207955..237207959, +
2.41e-66FFCP PHASE1:Hg19::chr2:40480968..40480972,-#_adc1ad9f0cbb8957437efc6d203881c8p@chr2:40480968..40480972, -
3.01e-66FFCP PHASE1:Hg19::chr4:62999501..62999517,+#_bad1e60ac900d5e49fab32830b452cf9p@chr4:62999501..62999517, +
3.01e-66FFCP PHASE2:Hg19::chr4:62999501..62999517,+#_bad1e60ac900d5e49fab32830b452cf9p@chr4:62999501..62999517, +
3.35e-66FFCP PHASE1:Hg19::chr7:35253487..35253489,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:35253487..35253489, -
3.35e-66FFCP PHASE1:Hg19::chr7:44179972..44179982,-#_00f976b9b63b66ea4f46f7ebebd1e975p2@MYL7
3.35e-66FFCP PHASE1:Hg19::chr5:65736120..65736128,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr5:65736120..65736128, -
3.35e-66FFCP PHASE2:Hg19::chr5:65736120..65736128,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr5:65736120..65736128, -
3.35e-66FFCP PHASE2:Hg19::chr7:44178491..44178498,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:44178491..44178498, -
3.35e-66FFCP PHASE2:Hg19::chr7:35253487..35253489,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:35253487..35253489, -
3.35e-66FFCP PHASE1:Hg19::chr7:44178491..44178498,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr7:44178491..44178498, -
3.35e-66FFCP PHASE2:Hg19::chr1:11905830..11905839,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr1:11905830..11905839, -
3.35e-66FFCP PHASE2:Hg19::chr7:44179972..44179982,-#_00f976b9b63b66ea4f46f7ebebd1e975p2@MYL7
3.35e-66FFCP PHASE2:Hg19::chr9:38650254..38650266,+#_00f976b9b63b66ea4f46f7ebebd1e975p@chr9:38650254..38650266, +
3.35e-66FFCP PHASE1:Hg19::chr9:38650254..38650266,+#_00f976b9b63b66ea4f46f7ebebd1e975p@chr9:38650254..38650266, +
3.35e-66FFCP PHASE1:Hg19::chr1:11905830..11905839,-#_00f976b9b63b66ea4f46f7ebebd1e975p@chr1:11905830..11905839, -
4.68e-66FFCP PHASE2:Hg19::chr10:112524543..112524547,+#_2b43ebfc718e686002f1d658707ef529p@chr10:112524543..112524547, +
4.68e-66FFCP PHASE1:Hg19::chr7:44180643..44180652,-#_2b43ebfc718e686002f1d658707ef529p3@MYL7
4.68e-66FFCP PHASE1:Hg19::chr10:112524543..112524547,+#_2b43ebfc718e686002f1d658707ef529p@chr10:112524543..112524547, +
4.68e-66FFCP PHASE2:Hg19::chr7:44180643..44180652,-#_2b43ebfc718e686002f1d658707ef529p3@MYL7
5.88e-66FFCP PHASE2:Hg19::chr6:36812225..36812238,-#_6383d00ed1700d11123d76136b0502d9p@chr6:36812225..36812238, -
5.88e-66FFCP PHASE1:Hg19::chr6:36812225..36812238,-#_6383d00ed1700d11123d76136b0502d9p@chr6:36812225..36812238, -
6.53e-66FFCP PHASE1:Hg19::chr2:168104544..168104551,+#_6706794ff9487bb2342359a937f82663p52@XIRP2
6.53e-66FFCP PHASE2:Hg19::chr2:168104544..168104551,+#_6706794ff9487bb2342359a937f82663p52@XIRP2
6.53e-66FFCP PHASE2:Hg19::chr4:62999459..62999462,+#_6706794ff9487bb2342359a937f82663p@chr4:62999459..62999462, +
6.53e-66FFCP PHASE1:Hg19::chr4:62999459..62999462,+#_6706794ff9487bb2342359a937f82663p@chr4:62999459..62999462, +
1.15e-65FFCP PHASE2:Hg19::chr7:123302841..123302854,+#_11c3f3e32e63b6f00697e6018ad79c94p@chr7:123302841..123302854, +
1.15e-65FFCP PHASE1:Hg19::chr10:127569398..127569410,-#_11c3f3e32e63b6f00697e6018ad79c94p5@DHX32
1.15e-65FFCP PHASE2:Hg19::chr10:127569398..127569410,-#_11c3f3e32e63b6f00697e6018ad79c94p5@DHX32
1.15e-65FFCP PHASE1:Hg19::chrX:121555838..121555874,+#_11c3f3e32e63b6f00697e6018ad79c94p@chrX:121555838..121555874, +










Property "Property value" (as page type) with input value "UBPROP:0000001 "Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000002 "relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.