FANTOM2 collaborative research

Background

The RIKEN Mouse Gene Encyclopedia Project, a systematic approach to determining the full coding potential of the mouse genome, involves collection and sequencing of full-length complementary DNAs and physical mapping of the corresponding genes to the mouse genome. We, the RIKEN Genome Exploration Research (GER) group, have organized an international meeting (FANTOM) last summer to annotate our first 21,076 cDNAs. The outcome was published in Nature vol.409, page 685-690.

After FANTOM meeting, RIKEN group has been continued to construct mouse fully-length cDNAs. For annotating these new and large collection of cDNAs with advanced strategy, we hold FANTOM2 collaborative research.

The FANTOM2 collaborative research

The FANTOM2 will consist of three parts;

Typhoon meeting (Brain storming meeting to develop new concept for higher annotation using about 45,000 FANTOM typhoon set as a test set)
MATRICS (Mouse Annotation Teleconference for RIken CDNA Sequences)
FANTOM2 Meeting (report and discuss about annotation results)

1. FANTOM2 Typhoon Meeting

We are planning to hold this meeting from October 15th to 19th, 2001 to discuss strategies and rules for higher-level functional annotation using information including expression profiline, mapping and protein interaction data, and conventional sequence similarity search. We will also discuss how the MATRICS (online annotation of Riken sequences) meeting should be organized. We have prepared about 45,000 sequences as a test set for FANTOM2 Typhoon meeting. We expect that a variety of useful analyses will be executed on these sequences before the FANTOM2 Typhoon meeting.

2. FANTOM2 MATRICS

MATRICS stands for Mouse Annotation Teleconference for RIken CDNA Sequence. This will be held between the FANTOM2-Typhoon meeting and the FANTOM2 Meeting. In this teleconference, curators will annotate RIKEN cDNA sequences via Internet with the FANTOM system in their offices using a secure server system (128-bit encrypted).

3. FANTOM2 Cherry Blossom Meeting

After the MATRICS, we plan to hold a two weeks-long meeting next spring, 2002 to report and discuss the functional annotation results and biologically interesting findings. The fruitful outcomes of these discussions will be described in a manuscript that will be submitted for publication.