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Coexpression cluster:C1112

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Full id: C1112_extraskeletal_corpus_Neural_thalamus_substantia_pons_medulla



Phase1 CAGE Peaks

Hg19::chr10:25304967..25304988,-p2@ENKUR
Hg19::chr16:19612967..19612983,+p7@C16orf62
Hg19::chr16:19896782..19896816,-p4@GPRC5B
Hg19::chr1:66458111..66458123,+p17@PDE4B
Hg19::chr1:66458291..66458304,+p9@PDE4B
Hg19::chr1:66458305..66458316,+p13@PDE4B
Hg19::chrX:43832628..43832644,-p1@NDP


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007601visual perception0.00871228837189771
GO:0050953sensory perception of light stimulus0.00871228837189771
GO:0005118sevenless binding0.00871228837189771
GO:00041153',5'-cyclic-AMP phosphodiesterase activity0.0152438119264595
GO:0001890placenta development0.0261230189931719
GO:0005626insoluble fraction0.0273585139144967
GO:0007033vacuole organization and biogenesis0.0273585139144967
GO:0007600sensory perception0.0371529700088947
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity0.0371529700088947
GO:0005102receptor binding0.0371529700088947
GO:0004112cyclic-nucleotide phosphodiesterase activity0.0371529700088947
GO:0008067metabotropic glutamate, GABA-B-like receptor activity0.0412847974420979
GO:0050877neurological system process0.0452851199130761



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.