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Coexpression cluster:C1169

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Full id: C1169_Urothelial_meningioma_medulloblastoma_Prostate_fibrosarcoma_Anulus_Nucleus



Phase1 CAGE Peaks

  Short description
Hg19::chr12:47472578..47472594,- p14@AMIGO2
Hg19::chr12:47472684..47472703,- p12@AMIGO2
Hg19::chr18:26736753..26736764,+ p@chr18:26736753..26736764
+
Hg19::chr18:43307294..43307345,+ p@chr18:43307294..43307345
+
Hg19::chr1:183212642..183212654,+ p@chr1:183212642..183212654
+
Hg19::chr21:39628993..39628998,+ p25@KCNJ15
Hg19::chr8:141728731..141728740,- p38@PTK2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0007157heterophilic cell adhesion0.0478276194456524
GO:0007172signal complex assembly0.0478276194456524
GO:0005886plasma membrane0.0478276194456524
GO:0042169SH2 domain binding0.0478276194456524
GO:0005242inward rectifier potassium channel activity0.0478276194456524
GO:0005925focal adhesion0.0478276194456524
GO:0005924cell-substrate adherens junction0.0478276194456524
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0478276194456524
GO:0030055cell-matrix junction0.0478276194456524



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
transitional epithelial cell1.50e-254
urothelial cell1.50e-254
gingival epithelial cell7.60e-193
endo-epithelial cell3.80e-1842
respiratory epithelial cell3.89e-1613
epithelial cell4.19e-13253
endodermal cell1.70e-1258
general ecto-epithelial cell1.39e-1014
stratified squamous epithelial cell2.92e-096
keratin accumulating cell2.92e-096
stratified epithelial cell2.92e-096
keratinizing barrier epithelial cell2.92e-096
epithelial fate stem cell2.92e-096
stratified epithelial stem cell2.92e-096
surface ectodermal cell2.92e-096
epithelial cell of Malassez3.34e-093
bronchial epithelial cell6.33e-093
epithelial cell of alimentary canal3.14e-0720
buccal mucosa cell4.08e-071
endothelial cell of viscerocranial mucosa4.08e-071
keratinized cell of the oral mucosa4.08e-071
bladder cell4.34e-071
lower urinary tract cell4.34e-071
Uber Anatomy
Ontology termp-valuen
urothelium6.71e-315
transitional epithelium9.95e-266
gingival epithelium7.60e-193
urinary bladder1.29e-122
lower urinary tract1.29e-122
epithelium of mucosa3.39e-128
mouth mucosa2.98e-1113
urinary system structure6.22e-1147
renal system1.14e-1048
mucosa4.11e-1020
endoderm-derived structure1.99e-09160
endoderm1.99e-09160
presumptive endoderm1.99e-09160
orifice2.43e-0936
lower respiratory tract epithelium6.33e-093
epithelium of bronchus6.33e-093
surface structure7.08e-0999
endo-epithelium2.66e-0882
gingiva2.29e-078
mammalian vulva3.62e-071
external female genitalia3.62e-071
jaw skeleton4.22e-074
splanchnocranium4.22e-074
urinary bladder urothelium4.34e-071
wall of urinary bladder4.34e-071
mucosa of urinary bladder4.34e-071
uterus or analog4.89e-071
cloaca7.18e-0714
anal region7.18e-0714
embryonic cloaca7.18e-0714
terminal part of digestive tract7.18e-0714
primitive urogenital sinus7.18e-0714
proctodeum7.18e-0714
Disease
Ontology termp-valuen
squamous cell carcinoma6.43e-0714


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0137961
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.10.187674
MA0017.10.380797
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.10.48922
MA0043.10.973609
MA0046.10.962263
MA0048.10.120314
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.362619
MA0056.10
MA0057.10.115382
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.10.198335
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.10.162298
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.0022316
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.11.11391
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.10.347695
MA0103.10.332048
MA0105.10.340955
MA0106.10.648997
MA0107.10.274127
MA0108.20.806528
MA0109.10
MA0111.10.45062
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.11.59899
MA0144.10.254954
MA0145.10.0807715
MA0146.10.0127148
MA0147.10.281049
MA0148.10.528066
MA0149.15.89542
MA0062.20.193221
MA0035.20.564239
MA0039.20.0170091
MA0138.21.6801
MA0002.20.213296
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.20.262665
MA0065.20.282161
MA0150.11.10099
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.102476
MA0155.10.071478
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.10.281681
MA0160.10.543522
MA0161.10
MA0162.10.0249953
MA0163.10.0167306
MA0164.10.678332
MA0080.20.344472
MA0018.20.650405
MA0099.20.572
MA0079.20.0015479
MA0102.21.51913
MA0258.10.687127
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


No analysis results for this cluster

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.