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Coexpression cluster:C117

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Full id: C117_serous_clear_kidney_neuroectodermal_mesothelioma_endometrial_Intestinal



Phase1 CAGE Peaks

  Short description
Hg19::chr10:3305882..3305893,+ p@chr10:3305882..3305893
+
Hg19::chr10:85857839..85857840,- p@chr10:85857839..85857840
-
Hg19::chr10:85931768..85931785,- p4@ENST00000514797
p4@uc001kct.2
Hg19::chr10:85931846..85931867,- p1@ENST00000514797
p1@uc001kct.2
Hg19::chr10:96731879..96731924,+ p@chr10:96731879..96731924
+
Hg19::chr11:11833036..11833048,- p@chr11:11833036..11833048
-
Hg19::chr11:89223721..89223728,- p@chr11:89223721..89223728
-
Hg19::chr12:123070114..123070123,+ p@chr12:123070114..123070123
+
Hg19::chr12:132680939..132680977,+ p@chr12:132680939..132680977
+
Hg19::chr12:132681008..132681011,+ p@chr12:132681008..132681011
+
Hg19::chr12:132681018..132681026,+ p@chr12:132681018..132681026
+
Hg19::chr12:132681039..132681046,+ p@chr12:132681039..132681046
+
Hg19::chr12:132681059..132681070,+ p@chr12:132681059..132681070
+
Hg19::chr12:31652588..31652610,- p@chr12:31652588..31652610
-
Hg19::chr12:39104065..39104071,- p@chr12:39104065..39104071
-
Hg19::chr13:23467567..23467577,+ p@chr13:23467567..23467577
+
Hg19::chr13:23479449..23479452,+ p@chr13:23479449..23479452
+
Hg19::chr13:23486051..23486062,+ p@chr13:23486051..23486062
+
Hg19::chr14:64405176..64405183,+ p@chr14:64405176..64405183
+
Hg19::chr15:75397998..75398004,- p@chr15:75397998..75398004
-
Hg19::chr16:2106134..2106163,+ p18@TSC2
Hg19::chr16:831621..831649,+ p@chr16:831621..831649
+
Hg19::chr17:36003553..36003559,- p6@DDX52
Hg19::chr17:36068486..36068493,+ p@chr17:36068486..36068493
+
Hg19::chr17:73554365..73554374,+ p@chr17:73554365..73554374
+
Hg19::chr17:74128596..74128610,- p@chr17:74128596..74128610
-
Hg19::chr17:74134377..74134388,- p@chr17:74134377..74134388
-
Hg19::chr18:11959017..11959052,+ p@chr18:11959017..11959052
+
Hg19::chr18:52274330..52274344,- p@chr18:52274330..52274344
-
Hg19::chr18:69246146..69246156,- p3@LOC100505776
Hg19::chr18:69246167..69246179,- p2@LOC100505776
Hg19::chr18:69246186..69246197,- p1@LOC100505776
Hg19::chr18:6982576..6982589,- p@chr18:6982576..6982589
-
Hg19::chr19:40697978..40698010,+ p6@MAP3K10
Hg19::chr19:40762956..40762973,- p@chr19:40762956..40762973
-
Hg19::chr1:205601064..205601087,- p4@ELK4
Hg19::chr1:214650069..214650072,- p@chr1:214650069..214650072
-
Hg19::chr1:214650077..214650084,- p@chr1:214650077..214650084
-
Hg19::chr1:214650108..214650118,- p@chr1:214650108..214650118
-
Hg19::chr1:215257098..215257110,+ p@chr1:215257098..215257110
+
Hg19::chr1:215257112..215257119,+ p@chr1:215257112..215257119
+
Hg19::chr1:224370589..224370611,+ p3@DEGS1
Hg19::chr1:46787487..46787492,- p@chr1:46787487..46787492
-
Hg19::chr1:46797583..46797614,- p@chr1:46797583..46797614
-
Hg19::chr1:94780142..94780153,- p@chr1:94780142..94780153
-
Hg19::chr1:94780176..94780187,- p@chr1:94780176..94780187
-
Hg19::chr20:15866720..15866725,- p@chr20:15866720..15866725
-
Hg19::chr20:15871874..15871910,- p@chr20:15871874..15871910
-
Hg19::chr20:15872559..15872568,- p@chr20:15872559..15872568
-
Hg19::chr20:15873011..15873014,- p@chr20:15873011..15873014
-
Hg19::chr20:15878694..15878728,- p@chr20:15878694..15878728
-
Hg19::chr20:15879525..15879530,- p@chr20:15879525..15879530
-
Hg19::chr20:15891295..15891297,- p@chr20:15891295..15891297
-
Hg19::chr20:15896547..15896555,- p@chr20:15896547..15896555
-
Hg19::chr20:15896790..15896803,- p@chr20:15896790..15896803
-
Hg19::chr20:15898490..15898493,- p@chr20:15898490..15898493
-
Hg19::chr20:15916678..15916682,- p@chr20:15916678..15916682
-
Hg19::chr20:15942024..15942025,- -
p@chr20:15942024..15942025
Hg19::chr20:15948322..15948327,- p@chr20:15948322..15948327
-
Hg19::chr20:15954227..15954237,- p@chr20:15954227..15954237
-
Hg19::chr20:15966439..15966448,- p@chr20:15966439..15966448
-
Hg19::chr20:15967531..15967544,+ p@chr20:15967531..15967544
+
Hg19::chr20:15967629..15967655,+ p@chr20:15967629..15967655
+
Hg19::chr20:15967658..15967661,+ +
p@chr20:15967658..15967661
Hg19::chr20:15967691..15967705,+ p@chr20:15967691..15967705
+
Hg19::chr20:58319374..58319386,- p@chr20:58319374..58319386
-
Hg19::chr20:60934189..60934206,- p@chr20:60934189..60934206
-
Hg19::chr20:60934239..60934260,- p@chr20:60934239..60934260
-
Hg19::chr20:62113538..62113571,- p@chr20:62113538..62113571
-
Hg19::chr21:44441260..44441273,+ p3@PKNOX1
Hg19::chr22:31495739..31495756,+ p33@SMTN
Hg19::chr22:31739255..31739259,- p28@PATZ1
Hg19::chr22:46812806..46812838,- p@chr22:46812806..46812838
-
Hg19::chr2:231906019..231906031,+ p6@C2orf72
Hg19::chr2:239066313..239066357,+ p@chr2:239066313..239066357
+
Hg19::chr2:28503793..28503800,+ p@chr2:28503793..28503800
+
Hg19::chr2:31637816..31637836,- p7@XDH
Hg19::chr2:34902620..34902625,+ p1@ENST00000423663
Hg19::chr2:34902895..34902908,+ p1@uc002rpc.1
Hg19::chr2:34935472..34935477,+ p@chr2:34935472..34935477
+
Hg19::chr2:34971950..34971953,+ p@chr2:34971950..34971953
+
Hg19::chr3:168582660..168582692,+ p@chr3:168582660..168582692
+
Hg19::chr3:168802151..168802153,- p@chr3:168802151..168802153
-
Hg19::chr3:168861573..168861582,- p@chr3:168861573..168861582
-
Hg19::chr3:168864427..168864464,- p19@MECOM
Hg19::chr3:168864831..168864851,- p9@MECOM
Hg19::chr3:168864936..168864953,- p8@MECOM
Hg19::chr3:168865144..168865160,- p6@MECOM
Hg19::chr3:168865250..168865272,- p5@MECOM
Hg19::chr3:168865278..168865292,- p14@MECOM
Hg19::chr3:168865323..168865337,- p15@MECOM
Hg19::chr3:168865364..168865376,- p11@MECOM
Hg19::chr3:168865497..168865516,- p16@MECOM
Hg19::chr4:135331403..135331405,- p@chr4:135331403..135331405
-
Hg19::chr4:135507221..135507238,- p@chr4:135507221..135507238
-
Hg19::chr4:159430869..159430885,- p1@ENST00000502566
Hg19::chr4:159442958..159442977,+ p4@RXFP1
Hg19::chr4:159443003..159443018,+ p3@RXFP1
Hg19::chr4:159443024..159443056,+ p1@RXFP1
Hg19::chr4:159446395..159446403,+ p@chr4:159446395..159446403
+
Hg19::chr4:159541085..159541093,+ p@chr4:159541085..159541093
+
Hg19::chr4:175184004..175184014,- p16@FBXO8
Hg19::chr4:175184030..175184041,- p13@FBXO8
Hg19::chr4:175184051..175184061,- p18@FBXO8
Hg19::chr4:175184162..175184175,- p9@FBXO8
Hg19::chr4:175184180..175184194,- p2@FBXO8
Hg19::chr4:175184203..175184220,- p6@FBXO8
Hg19::chr4:175184241..175184250,- p14@FBXO8
Hg19::chr4:175204717..175204728,- p17@FBXO8
Hg19::chr4:25649638..25649642,+ p@chr4:25649638..25649642
+
Hg19::chr5:175799252..175799262,- p@chr5:175799252..175799262
-
Hg19::chr5:31936363..31936370,+ p19@PDZD2
Hg19::chr5:31936389..31936400,+ p11@PDZD2
Hg19::chr5:36105527..36105539,- p@chr5:36105527..36105539
-
Hg19::chr6:137844183..137844191,- p@chr6:137844183..137844191
-
Hg19::chr6:13925318..13925342,+ p2@RNF182
Hg19::chr6:14049473..14049508,+ p@chr6:14049473..14049508
+
Hg19::chr6:24323980..24323989,- p@chr6:24323980..24323989
-
Hg19::chr6:47602833..47602848,+ p@chr6:47602833..47602848
+
Hg19::chr6:64025774..64025778,- p@chr6:64025774..64025778
-
Hg19::chr6:64043904..64043907,- p@chr6:64043904..64043907
-
Hg19::chr6:64049378..64049403,- p@chr6:64049378..64049403
-
Hg19::chr6:64050722..64050726,- p@chr6:64050722..64050726
-
Hg19::chr6:64145806..64145815,- p@chr6:64145806..64145815
-
Hg19::chr6:64151611..64151636,- p@chr6:64151611..64151636
-
Hg19::chr6:64152250..64152255,- p@chr6:64152250..64152255
-
Hg19::chr6:72241518..72241524,+ p@chr6:72241518..72241524
+
Hg19::chr6:75233360..75233363,+ p@chr6:75233360..75233363
+
Hg19::chr7:107643719..107643730,- p9@LAMB1
Hg19::chr7:107644847..107644884,- p@chr7:107644847..107644884
-
Hg19::chr7:107707064..107707079,- p@chr7:107707064..107707079
-
Hg19::chr7:107707083..107707099,- p@chr7:107707083..107707099
-
Hg19::chr7:134627808..134627842,+ p@chr7:134627808..134627842
+
Hg19::chr7:138816862..138816869,- p@chr7:138816862..138816869
-
Hg19::chr7:151791137..151791153,+ p3@GALNT11
Hg19::chr7:151791485..151791495,+ p15@GALNT11
Hg19::chr7:98735181..98735195,- p@chr7:98735181..98735195
-
Hg19::chr7:98735218..98735228,- p@chr7:98735218..98735228
-
Hg19::chr7:98735238..98735250,- p@chr7:98735238..98735250
-
Hg19::chr8:101363016..101363029,+ p@chr8:101363016..101363029
+
Hg19::chr8:142247795..142247863,- p@chr8:142247795..142247863
-
Hg19::chr8:142247940..142247948,- p@chr8:142247940..142247948
-
Hg19::chr8:144124493..144124500,+ p8@C8orf31
Hg19::chr8:144124531..144124572,+ p2@C8orf31
Hg19::chr8:20070210..20070250,+ p@chr8:20070210..20070250
+
Hg19::chr9:132472174..132472192,+ p@chr9:132472174..132472192
+
Hg19::chr9:136856204..136856219,+ p@chr9:136856204..136856219
+
Hg19::chr9:138466794..138466798,+ p1@ENST00000445997
Hg19::chr9:90000420..90000454,- p@chr9:90000420..90000454
-
Hg19::chr9:90680465..90680480,- p1@uc004apv.1
Hg19::chrX:16329834..16329838,- p@chrX:16329834..16329838
-
Hg19::chrX:16422567..16422570,- p@chrX:16422567..16422570
-
Hg19::chrX:16530591..16530601,- p@chrX:16530591..16530601
-
Hg19::chrX:16530614..16530628,- p@chrX:16530614..16530628
-
Hg19::chrX:35711783..35711785,+ p@chrX:35711783..35711785
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0005515protein binding0.0291416460614624
GO:0004855xanthine oxidase activity0.0291416460614624
GO:0043257laminin-8 complex0.0291416460614624
GO:0005607laminin-2 complex0.0291416460614624
GO:0016727oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor0.0291416460614624
GO:0016726oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor0.0364195514862496
GO:0004854xanthine dehydrogenase activity0.0364195514862496
GO:0043259laminin-10 complex0.0364195514862496
GO:0050794regulation of cellular process0.0436944567728137
GO:0004706JUN kinase kinase kinase activity0.0436944567728137
GO:0033559unsaturated fatty acid metabolic process0.0477161790289686
GO:0006636unsaturated fatty acid biosynthetic process0.0477161790289686
GO:0044424intracellular part0.0477161790289686
GO:0050789regulation of biological process0.0477161790289686
GO:0042803protein homodimerization activity0.0477161790289686



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
serous secreting cell9.37e-991
seromucus secreting cell2.74e-502
Uber Anatomy
Ontology termp-valuen
epithelium of female gonad9.37e-991
epithelium of gonad2.74e-502
female gonad5.28e-0913
Disease
Ontology termp-valuen
ovary epithelial cancer9.37e-991
clear cell adenocarcinoma4.52e-502
adenocarcinoma4.64e-1725
female reproductive organ cancer6.71e-1627
reproductive organ cancer6.74e-1529
ovarian cancer1.86e-0814


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488104.046258086408270.000212176669014230.00246710299879505
ESR1#2099152.97760677059560.000176757459151850.00214905381564146



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data