Coexpression cluster:C1286

Full id: C1286_myelodysplastic_acute_leukemia_biphenotypic_CD14CD16_splenic_Dendritic

Phase1 CAGE Peaks

Hg19::chr8:130560794..130560810,-	p@chr8:130560794..130560810 -
Hg19::chr8:130560812..130560823,-	p@chr8:130560812..130560823 -
Hg19::chr8:130560843..130560854,-	p@chr8:130560843..130560854 -
Hg19::chr8:130560902..130560915,-	p@chr8:130560902..130560915 -
Hg19::chr8:130560925..130560948,-	p@chr8:130560925..130560948 -
Hg19::chr8:130560949..130560959,-	p@chr8:130560949..130560959 -
Hg19::chr8:27184282..27184305,+	p6@PTK2B

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	1.62e-46	112
common myeloid progenitor	1.62e-46	112
hematopoietic stem cell	2.79e-42	172
angioblastic mesenchymal cell	2.79e-42	172
hematopoietic oligopotent progenitor cell	3.60e-40	165
hematopoietic multipotent progenitor cell	3.60e-40	165
hematopoietic cell	1.78e-38	182
CD14-positive, CD16-negative classical monocyte	3.78e-35	42
macrophage dendritic cell progenitor	6.83e-32	65
classical monocyte	1.46e-31	45
granulocyte monocyte progenitor cell	3.81e-31	71
monopoietic cell	1.21e-30	63
monocyte	1.21e-30	63
monoblast	1.21e-30	63
promonocyte	1.21e-30	63
myeloid leukocyte	3.32e-30	76
myeloid lineage restricted progenitor cell	1.20e-28	70
leukocyte	4.95e-27	140
nongranular leukocyte	3.76e-25	119
hematopoietic lineage restricted progenitor cell	1.38e-23	124
intermediate monocyte	1.39e-09	9
CD14-positive, CD16-positive monocyte	1.39e-09	9
mesenchymal cell	1.68e-07	358
connective tissue cell	8.48e-07	365

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	6.65e-35	102
blood island	6.65e-35	102
hemolymphoid system	3.64e-31	112
bone marrow	1.79e-26	80
adult organism	4.05e-24	115
bone element	4.43e-23	86
immune system	4.41e-21	115
skeletal element	4.67e-18	101
skeletal system	4.67e-18	101
neural tube	6.28e-15	57
neural rod	6.28e-15	57
future spinal cord	6.28e-15	57
neural keel	6.28e-15	57
telencephalon	2.15e-14	34
regional part of forebrain	3.49e-14	41
forebrain	3.49e-14	41
future forebrain	3.49e-14	41
gray matter	3.80e-14	34
brain grey matter	3.80e-14	34
regional part of telencephalon	8.30e-14	33
anterior neural tube	1.37e-13	42
cerebral hemisphere	2.78e-13	32
regional part of brain	4.52e-12	59
regional part of cerebral cortex	1.09e-11	22
neocortex	1.79e-10	20
brain	9.94e-10	69
future brain	9.94e-10	69
cerebral cortex	1.51e-09	25
pallium	1.51e-09	25
central nervous system	3.22e-09	82
neural plate	2.92e-08	86
presumptive neural plate	2.92e-08	86
neurectoderm	9.38e-08	90
pre-chordal neural plate	2.06e-07	61
regional part of nervous system	4.08e-07	94
nervous system	4.08e-07	94
basal ganglion	7.56e-07	9
nuclear complex of neuraxis	7.56e-07	9
aggregate regional part of brain	7.56e-07	9
collection of basal ganglia	7.56e-07	9
cerebral subcortex	7.56e-07	9

Disease

Ontology term	p-value	n
myeloid leukemia	3.08e-17	31
leukemia	2.07e-15	39
hematologic cancer	9.08e-13	51
immune system cancer	9.08e-13	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BATF#10538	6	20.8781158219745	3.22775058778003e-08	2.17345611629374e-06
BCL11A#53335	6	24.3166758030918	1.29931738009616e-08	9.61043965013196e-07
EBF1#1879	7	8.906466846569	2.2473547136215e-07	1.19324595290247e-05
IRF4#3662	4	12.5225786781395	0.000135673113103555	0.00177719356069513
MEF2A#4205	4	10.7104176626537	0.000248736097009112	0.00268309742155904
NFKB1#4790	7	5.48806342419384	6.66568321176054e-06	0.000195002041723546
PAX5#5079	6	5.71677045529528	6.92762487228137e-05	0.00109956567482704
POU2F2#5452	6	7.80524919235073	1.11144903558223e-05	0.000284715785693336
RXRA#6256	3	8.60340734534283	0.00371646156149726	0.0187409361702097
SRF#6722	6	11.8261527961438	9.50741412579311e-07	4.0677788770328e-05
USF1#7391	6	5.45271366617825	9.13505145927422e-05	0.00133173595666547
USF2#7392	6	11.1361691872025	1.35815928956223e-06	5.33853210547948e-05
YY1#7528	6	4.20957492844616	0.00041168337886575	0.0039233324578301

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.