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Coexpression cluster:C1294


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Full id: C1294_Hepatocyte_kidney_liver_seminal_salivary_ductus_thyroid

Phase1 CAGE Peaks

  Short description
Hg19::chr10:104597286..104597295,- p5@CYP17A1
Hg19::chr10:104597311..104597320,- p4@CYP17A1
Hg19::chr10:104597342..104597349,- p6@CYP17A1
Hg19::chr16:20548438..20548449,- p2@ACSM2B
Hg19::chr16:20548514..20548523,- p3@ACSM2B
Hg19::chr18:42277095..42277130,+ p8@SETBP1

Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset

6.15571812123322e-050.03896569570740632130Biological oxidations (Reactome):REACT_13433

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset

GO IDGO nameFDR corrected p-value
GO:0004508steroid 17-alpha-monooxygenase activity0.00732956552454962
GO:0006704glucocorticoid biosynthetic process0.0122145041866808
GO:0047760butyrate-CoA ligase activity0.0122145041866808
GO:0008211glucocorticoid metabolic process0.0128244743045017
GO:0006700C21-steroid hormone biosynthetic process0.0154653297256805
GO:0008395steroid hydroxylase activity0.0154653297256805
GO:0008207C21-steroid hormone metabolic process0.0154653297256805
GO:0044255cellular lipid metabolic process0.0154653297256805
GO:0016878acid-thiol ligase activity0.0154653297256805
GO:0009636response to toxin0.0162555467239316
GO:0006629lipid metabolic process0.0162555467239316
GO:0016877ligase activity, forming carbon-sulfur bonds0.0162555467239316
GO:0043025cell soma0.0170852081807174
GO:0042446hormone biosynthetic process0.0196738632930984
GO:0019825oxygen binding0.0245351119003364
GO:0043005neuron projection0.0295746793628032
GO:0007548sex differentiation0.0295746793628032
GO:0003006reproductive developmental process0.0295746793628032
GO:0042445hormone metabolic process0.0295746793628032
GO:0006694steroid biosynthetic process0.0295746793628032
GO:0042598vesicular fraction0.0485203145647627
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen0.0485203145647627
GO:0031980mitochondrial lumen0.0485203145647627
GO:0005759mitochondrial matrix0.0485203145647627
GO:0006631fatty acid metabolic process0.0485203145647627
GO:0043231intracellular membrane-bound organelle0.0485203145647627
GO:0043227membrane-bound organelle0.0485203145647627

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


Cell Type
Ontology termp-valuen
endodermal cell3.57e-0959
Uber Anatomy
Ontology termp-valuen
adult organism6.08e-28115
exocrine gland3.74e-1031
exocrine system3.74e-1031
gland of gut2.16e-0710
saliva-secreting gland2.52e-076
gland of oral region2.52e-076
gland of foregut2.52e-076
oral gland2.52e-076
oral cavity2.52e-076
male reproductive organ4.35e-0711
male organism6.93e-0722
male reproductive system6.93e-0722

Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs

Jaspar motifs

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset


No analysis results for this cluster

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.

link to data source

This analysis result is provided for C0 - C305 clusters.