Coexpression cluster:C1342

Full id: C1342_CD14_CD19_Eosinophils_Neutrophils_Peripheral_Natural_Basophils

Phase1 CAGE Peaks

Hg19::chr11:58346281..58346294,-	p@chr11:58346281..58346294 -
Hg19::chr1:155108603..155108650,-	p@chr1:155108603..155108650 -
Hg19::chr1:65532746..65532757,+	p@chr1:65532746..65532757 +
Hg19::chr5:137879399..137879412,-	p4@ETF1
Hg19::chr9:102581879..102581894,+	p@chr9:102581879..102581894 +
Hg19::chrX:24167676..24167700,-	p3@ZFX-AS1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016149	translation release factor activity, codon specific	0.00120687625103026
GO:0006449	regulation of translational termination	0.00241375250206052
GO:0043022	ribosome binding	0.00261489854389889
GO:0008079	translation termination factor activity	0.00261489854389889
GO:0006415	translational termination	0.00261489854389889
GO:0003747	translation release factor activity	0.00261489854389889
GO:0043021	ribonucleoprotein binding	0.00293098518107349
GO:0043624	cellular protein complex disassembly	0.00337925350288473
GO:0043241	protein complex disassembly	0.00337925350288473
GO:0032984	macromolecular complex disassembly	0.00337925350288473
GO:0022411	cellular component disassembly	0.0053760851182257
GO:0006417	regulation of translation	0.0173272947469344
GO:0031326	regulation of cellular biosynthetic process	0.0173272947469344
GO:0008135	translation factor activity, nucleic acid binding	0.0173272947469344
GO:0009889	regulation of biosynthetic process	0.0174594764315711
GO:0051246	regulation of protein metabolic process	0.0318313611209231

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	2.22e-42	140
hematopoietic stem cell	2.46e-40	172
angioblastic mesenchymal cell	2.46e-40	172
hematopoietic cell	9.94e-40	182
hematopoietic oligopotent progenitor cell	2.03e-37	165
hematopoietic multipotent progenitor cell	2.03e-37	165
hematopoietic lineage restricted progenitor cell	6.39e-36	124
nongranular leukocyte	7.34e-35	119
CD14-positive, CD16-negative classical monocyte	2.01e-25	42
classical monocyte	3.56e-25	45
myeloid leukocyte	7.18e-25	76
granulocyte monocyte progenitor cell	6.29e-23	71
myeloid cell	1.23e-22	112
common myeloid progenitor	1.23e-22	112
myeloid lineage restricted progenitor cell	9.21e-21	70
macrophage dendritic cell progenitor	2.11e-20	65
monopoietic cell	2.62e-19	63
monocyte	2.62e-19	63
monoblast	2.62e-19	63
promonocyte	2.62e-19	63
mesenchymal cell	3.00e-18	358
connective tissue cell	9.17e-18	365
motile cell	3.04e-16	390
lymphoid lineage restricted progenitor cell	1.49e-13	52
lymphocyte	1.73e-13	53
common lymphoid progenitor	1.73e-13	53
multi fate stem cell	4.69e-12	430
stem cell	1.19e-11	444
somatic stem cell	1.96e-11	436
native cell	1.61e-09	722
intermediate monocyte	2.19e-07	9
CD14-positive, CD16-positive monocyte	2.19e-07	9
lymphocyte of B lineage	2.41e-07	24
pro-B cell	2.41e-07	24
B cell	3.95e-07	14

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	4.94e-21	102
blood island	4.94e-21	102
bone marrow	4.37e-19	80
bone element	9.58e-18	86
connective tissue	1.25e-17	375
hemolymphoid system	2.22e-16	112
skeletal element	7.69e-15	101
skeletal system	7.69e-15	101
immune system	8.85e-11	115
lateral plate mesoderm	2.27e-07	216

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.