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Coexpression cluster:C1351

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Full id: C1351_immature_CD14_CD34_Peripheral_Mast_Basophils_Natural



Phase1 CAGE Peaks

Hg19::chr11:75048593..75048598,+p@chr11:75048593..75048598
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Hg19::chr12:50099534..50099545,+p@chr12:50099534..50099545
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Hg19::chr2:98279494..98279517,+p@chr2:98279494..98279517
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Hg19::chr2:98279571..98279582,+p@chr2:98279571..98279582
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Hg19::chr3:71113296..71113307,+p@chr3:71113296..71113307
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Hg19::chr6:138114040..138114043,+p@chr6:138114040..138114043
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
granulocyte monocyte progenitor cell1.41e-1971
myeloid leukocyte8.42e-1976
CD14-positive, CD16-negative classical monocyte1.33e-1842
leukocyte1.65e-18140
classical monocyte1.77e-1845
macrophage dendritic cell progenitor7.17e-1765
myeloid lineage restricted progenitor cell1.58e-1670
monopoietic cell1.35e-1563
monocyte1.35e-1563
monoblast1.35e-1563
promonocyte1.35e-1563
hematopoietic lineage restricted progenitor cell3.69e-15124
nongranular leukocyte4.39e-14119
multi fate stem cell8.72e-14430
somatic stem cell7.97e-13436
stem cell9.46e-13444
hematopoietic cell1.26e-12182
hematopoietic stem cell8.04e-12172
angioblastic mesenchymal cell8.04e-12172
mesenchymal cell4.49e-11358
myeloid cell5.95e-11112
common myeloid progenitor5.95e-11112
hematopoietic oligopotent progenitor cell9.62e-11165
hematopoietic multipotent progenitor cell9.62e-11165
connective tissue cell4.69e-10365
motile cell9.98e-09390
somatic cell4.06e-07591
Uber Anatomy
Ontology termp-valuen
bone marrow8.75e-2080
bone element9.09e-1986
skeletal element2.80e-16101
skeletal system2.80e-16101
hematopoietic system4.34e-16102
blood island4.34e-16102
hemolymphoid system3.13e-15112
immune system5.46e-14115
musculoskeletal system1.60e-11167
connective tissue4.58e-10375
lateral plate mesoderm2.72e-08216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538312.17890089615180.00125981487125340.00846133796391212
EBF1#187945.937644564379340.001975153636421710.0114888928228486
FOS#235345.998636872596270.001899823711886350.0111827587581411
FOSL1#8061213.23785990545770.00888833088009090.0337191568756198
GATA1#262336.780154071900220.006765763983348560.0287473403033743
GATA2#262448.496621155702660.0004993024497617180.00440911884253522
JUN#372536.256414596168170.008486346850954870.032407238976448
MEF2A#420539.371615454822030.002687399947103910.0147985533626271
NFKB1#479043.658708949462560.01207927289015230.0438235030178419
SPI1#668845.469549005681820.00269730053614140.014840552665371



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.