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Coexpression cluster:C1413

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Full id: C1413_Mast_immature_CD14_Dendritic_Basophils_CD8_Natural



Phase1 CAGE Peaks

Hg19::chr15:86124958..86125013,+p9@AKAP13
Hg19::chr15:86125966..86125977,+p53@AKAP13
Hg19::chr15:86125992..86126003,+p36@AKAP13
Hg19::chr6:132455044..132455047,-p@chr6:132455044..132455047
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Hg19::chr6:138115750..138115757,-p@chr6:138115750..138115757
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Hg19::chr7:28725501..28725529,+p14@CREB5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004691cAMP-dependent protein kinase activity0.0271944660842256
GO:0004690cyclic nucleotide-dependent protein kinase activity0.0271944660842256



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.43e-45140
hematopoietic stem cell1.33e-36172
angioblastic mesenchymal cell1.33e-36172
hematopoietic cell6.45e-35182
myeloid leukocyte1.85e-3376
hematopoietic lineage restricted progenitor cell2.48e-33124
hematopoietic oligopotent progenitor cell2.71e-33165
hematopoietic multipotent progenitor cell2.71e-33165
nongranular leukocyte1.55e-31119
CD14-positive, CD16-negative classical monocyte8.16e-3042
granulocyte monocyte progenitor cell1.13e-2971
classical monocyte2.78e-2645
myeloid lineage restricted progenitor cell9.63e-2670
myeloid cell2.88e-25112
common myeloid progenitor2.88e-25112
macrophage dendritic cell progenitor2.95e-2565
monopoietic cell1.06e-2363
monocyte1.06e-2363
monoblast1.06e-2363
promonocyte1.06e-2363
granulocyte8.70e-088
lymphocyte1.14e-0753
common lymphoid progenitor1.14e-0753
dendritic cell1.22e-0710
lymphoid lineage restricted progenitor cell1.33e-0752
mesenchymal cell4.08e-07358
intermediate monocyte4.82e-079
CD14-positive, CD16-positive monocyte4.82e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.54e-30102
blood island1.54e-30102
hemolymphoid system3.58e-28112
bone marrow3.35e-2480
bone element4.99e-2186
adult organism5.10e-19115
immune system9.51e-19115
skeletal element7.91e-15101
skeletal system7.91e-15101
lateral plate mesoderm4.72e-14216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.