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Coexpression cluster:C1614

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Full id: C1614_Fibroblast_Small_Bronchial_Mallassezderived_Tracheal_Sebocyte_mesothelioma



Phase1 CAGE Peaks

Hg19::chr11:12108410..12108424,+p1@ENST00000527997
Hg19::chr12:66037894..66037897,-p@chr12:66037894..66037897
-
Hg19::chr12:76257534..76257544,+p@chr12:76257534..76257544
+
Hg19::chr2:208259497..208259500,-p@chr2:208259497..208259500
-
Hg19::chr8:129335371..129335388,+p@chr8:129335371..129335388
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
multilaminar epithelium1.12e-2182
somite2.69e-2183
paraxial mesoderm2.69e-2183
presomitic mesoderm2.69e-2183
presumptive segmental plate2.69e-2183
trunk paraxial mesoderm2.69e-2183
presumptive paraxial mesoderm2.69e-2183
dermomyotome1.95e-1870
vasculature3.15e-1879
vascular system3.15e-1879
trunk mesenchyme3.29e-18143
artery1.26e-1742
arterial blood vessel1.26e-1742
arterial system1.26e-1742
skeletal muscle tissue8.96e-1661
striated muscle tissue8.96e-1661
myotome8.96e-1661
vessel1.66e-1569
unilaminar epithelium2.34e-15138
muscle tissue4.94e-1563
musculature4.94e-1563
musculature of body4.94e-1563
blood vessel1.12e-1460
epithelial tube open at both ends1.12e-1460
blood vasculature1.12e-1460
vascular cord1.12e-1460
systemic artery4.31e-1433
systemic arterial system4.31e-1433
splanchnic layer of lateral plate mesoderm9.78e-1484
epithelial tube2.53e-13118
trunk2.82e-13216
cardiovascular system3.24e-13110
circulatory system4.45e-12113
cell layer1.31e-11312
epithelium3.44e-11309
surface structure4.87e-1095
aorta2.97e-0921
aortic system2.97e-0921
organism subdivision3.23e-09365
integument1.51e-0845
integumental system1.51e-0845
anatomical system6.11e-08625
anatomical group8.63e-08626
mesenchyme1.27e-07238
entire embryonic mesenchyme1.27e-07238
skin of body3.45e-0740
mesoderm4.35e-07448
mesoderm-derived structure4.35e-07448
presumptive mesoderm4.35e-07448
Disease
Ontology termp-valuen
ovarian cancer1.15e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.