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{{Coexpression_clusters
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|full_id=C1842_Preadipocyte_epithelioid_Synoviocyte_tenocyte_renal_Fibroblast_spindle
|id=C1842
|ontology_enrichment_celltype=CL:0000057!2.06e-15!75;CL:0000055!2.84e-15!180;CL:0002334!1.76e-09!12;CL:0002620!5.82e-09!23
|ontology_enrichment_disease=
|ontology_enrichment_uberon=
|tfbs_overrepresentation=0.23317,0.0958562,0.877965,0.078254,0.310241,0.43203,0.0706464,0.5903,0.0539364,0.0424746,0.221396,0.346629,0.294377,0.201017,0.235304,0.101024,0.223746,0.158251,0.0865245,0.173528,0.29418,0.211047,0.13286,0.153106,0.0683222,0.332688,0.324018,0.146582,0.227906,0.150721,0.31768,0.182756,0.0298713,0.322378,0.108398,0.136785,0.856615,0.070583,0.192426,0.108683,0.155571,0.0406818,0.222325,0.287476,0.193292,0.0596699,0.0625547,0.28382,0.178503,0.193726,0.243359,0.0886583,0.114185,0.150136,0.308837,0.0632035,0.172598,0.328738,0.127101,0.169687,0.0485674,0.236408,0.174369,0.123348,0.0892839,0.0827236,0.515105,0.0980005,0.139298,0.262613,0.547889,0.110232,0.143944,0.190944,0.012429,0.0283664,0.155593,0.0717582,0.0613084,0.0120583,0.154245,0.348799,0.0698251,0.183986,0.436695,0.38341,0.104918,0.323505,0.790836,0.102375,0.138802,0.0812726,0.153861,0.0777027,0.138224,0.184264,0.769004,0.242703,0.149747,0.413729,0.0939617,0.416542,0.225088,0.0610111,0.337778,0.0672793,0.109136,0.497282,0.228612,0.407248,0.285407,0.0560173,0.23661,0.0293017,0.162943,0.0556189,0.0336673,0.0926302,0.220791,0.13579,0.262107,0.331577,0.222452,0.138843,0.164723,0.277102,0.146529,0.0245339,0.136609,0.214614,0.0973103,0.121587,0.0935301,0.0376876,0.200735,0.173595,0.105753,0.0905147,0.0544577,0.0065834,0.037671,0.203496,0.316207,0.246229,0.779726,0.112838,0.159217,0.1364,0.0640569,0.193163,0.311509,0.227801,0.282656,0.0439093,0.070163,0.188135,0.121467,0.350865,0.0846706,0.0555742,0.349932,0.153706,0.186743,0.23397,0.412853,0.183121,0.065826,0.203135,0.0663482,0.463935,0.281162,0.218835,0.646289,0.0885874,0.129639,0.145577,0.22277,0.284267,0.27935,0.0586816,0.250461,0.195671,0.0452583,0.185103,0.11983,0.190123,0.286036,0.0660586,0.134265,0.272191,0.172119,0.292239,0.196376,0.351465,0.18064,0.0772176,0.126988,0.0984435,0.110187,0.176022,0.144361,0.0986228,0.0508565,0.0989516,0.21691,0.393782,0.412989,0.240045,0.319604,0.279218,0.0752697,0.167805,0.193654,0.180992,0.464566,0.265567,0.258402,0.162511,0.102771,0.165687,0.225173,0.540012,0.246322,0.253699,0.120044,0.201982,0.220536,0.139142,0.0987108,0.09782,0.754769,0.554981,0.0687568,0.124225,0.1547,0.150448,0.0774663,0.398789,0.257365,0.331711,0.285222,0.511,0.158559,0.134615,0.186192,0.217494,0.132125,0.179065,0.540443,0.187334,0.250769,0.289141,0.289982,0.157983,0.158078,0.251693,0.172268,0.313249,0.113261,0.766691,0.101058,0.274448,0.25718,0.204241,0.0568578,0.131428,0.131579,0.148683,0.188945,0.122666,0.419402,0.103245,0.387442,0.627158,0.14011,0.0626022,0.2074,0.769028,0.875285,0.115057,0.814323,0.161661,0.944588,0.935701,0.493893,0.808889,0.396701,0.626645,0.541514,0.460217,0.675971,0.487888,0.568246,0.486439,0.720623,0.796904,0.410803,0.43779,0.0576112,0.569955,0.766049,0.780281,0.292173,0.0406515,0.284119,0.0144364,0.176507,0.488132,0.336705,0.604733,0.545464,0.645432,0.824163,0.714193,0.706516,0.537972,0.591562,0.668584,0.385794,0.417358,0.450485,0.665656,0.470142,0.344006,0.688397,0.785741,0.426591,0.467379,0.762263,0.437202,0.628658,0.761311,0.592924,0.438692,0.660225,0.619033,0.541742,0.762222,0.463603,0.285074,0.870229,0.943261,0.899362,0.101555,0.362164,0.289863,0.507647,0.721501,0.409489,0.80581,0.688223,0.699429,0.707862,0.379008,0.423719,0.655494,0.256985,0.109234,0.11883,0.288602,0.779806,0.909149,0.766165,0.588284,0.843506,0.732646,0.737273,0.628596,0.337121,0.464864,0.861932,0.0740433,0.121457,0.351733,0.826323,0.773103,0.687274,0.441154,0.503865,0.660832,0.43388,0.483295,0.128,0.418989,0.935814,0.606622,0.350461,0.495024,0.307173,0.246694,0.752605,0.598317,0.666615,0.597346,0.702113,0.961692,0.493489,0.229501,0.230597,0.555864,0.544572,0.627794,0.641833,0.383956,0.241286,0.0764074,0.217887,0.393543,0.214395,0.158849,0.732038,0.439833,0.427746,0.504398,0.456725,0.455709,0.199515,0.688249,0.708682,0.427794,0.398041,0.170667,0.347879,0.58021,0.593219,0.529253,0.64728,0.903142,0.319495,0.711229,0.827435,0.616333,0.407113,0.498776,0.738012,0.423517,0.224914,0.636791,0.706243,0.251608,0.365107,0.539805,0.356278,0.295455,0.144104,0.0972855,0.710825,0.80526,0.508875,0.725283,0.512109,0.658411,0.578577,0.818493,0.809533,0.469232,0.113555,0.0910724,0.299839,0.126587,0.0940929,0.22877,0.343849,0.315824,0.622796,0.621499,0.29873,0.179502,0.43406,0.0715061,0.452515,0.201779,0.214491,0.171725,0.412647,0.102448,0.550877,0.029672,0.453305,0.421335,0.561724,0.0762646,0.266371,0.183582,0.168118,0.145381,0.140277,0.251925,0.172066,0.0720324,0.00647589,0.19738,0.205854,0.32541,0.301472,0.507714,0.0818982,0.134306,0.108669,0.284804,0.178494,0.338195,0.490571,0.304235,0.210475,0.294266,0.0790025,0.310539,0.580279,0.203728,0.275452,0.288155,0.265827,0.141761,0.153627,0.0186891,0.342497,0.171961,0.415228,0.00800917,0.272406,0.223952,0.327153,0.0496113,0.20949,0.0730994,0.0857377,0.323267,0.24204,0.129414,0.157037,0.252398,0.197279,0.146467,0.0912686,0.425114,0.7034,0.218241,0.0242146,0.10708,0.327369,0.339826,0.12998,0.123097,0.254847,0.300809,0.0898207,0.126545,0.0918749,0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}}

Latest revision as of 11:53, 17 September 2013


Full id: C1842_Preadipocyte_epithelioid_Synoviocyte_tenocyte_renal_Fibroblast_spindle



Phase1 CAGE Peaks

Hg19::chr1:200379777..200379783,-p@chr1:200379777..200379783
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Hg19::chr1:200452510..200452521,-p@chr1:200452510..200452521
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Hg19::chr1:200452556..200452567,-p@chr1:200452556..200452567
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Hg19::chr1:200452599..200452614,-p@chr1:200452599..200452614
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Hg19::chr1:200452620..200452639,-p@chr1:200452620..200452639
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
fibroblast2.65e-1876
preadipocyte4.09e-1812
skin fibroblast1.25e-1423
preadipocyte of the breast7.66e-093
fibrocyte2.00e-083
attachment cell2.00e-083
tendon cell2.00e-083
omentum preadipocyte2.37e-083
cell of skeletal muscle5.47e-089
Schwann cell4.58e-072
GAG secreting cell9.99e-079
carbohydrate secreting cell9.99e-079
Uber Anatomy
Ontology termp-valuen
dense regular connective tissue2.00e-083
tendon2.00e-083
regular connective tissue2.00e-083
integument8.41e-0846
integumental system8.41e-0846
articulation1.53e-078
skeletal joint1.53e-078
articular system1.53e-078
skin of body7.94e-0741
Disease
Ontology termp-valuen
musculoskeletal system disease7.78e-085
myotonic disease7.78e-085
muscle tissue disease7.78e-085
myopathy7.78e-085
muscular disease7.78e-085
myotonic dystrophy7.78e-085


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00991994
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.11.18667
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.00220137
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.11.12656
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.12.78334
MA0141.11.29278
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.11.57313
MA0149.10.681935
MA0062.20.284987
MA0035.21.65235
MA0039.20.311551
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.21.66926
MA0079.20.000396307
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538419.48624143384291.37275300118359e-050.000332180145251652
BCL11A#53335422.69556408288567.49488101632307e-060.0002143954747915
BCL3#602427.63768224299073.425174836939e-060.000114142257433016
BRCA1#672416.1473845145792.89130901545765e-050.000605141126784331
CEBPB#105146.376918100659850.001113944176677320.0076549030048692
EBF1#187947.12517347725520.0007230531046774210.00577154870065769
EP300#203356.77394172622327.00901578206049e-050.00110877703614452
FOS#235347.198364247115530.0006947858453382510.00559724922101833
FOSL1#8061431.77086377309841.96715033715934e-067.22642328746341e-05
FOSL2#2355413.54416048364945.7953819349229e-050.000964871503110812
GATA2#2624410.19594538684320.0001775447777609820.00215737045312149
GTF2F1#2962410.19172870140610.000177833889427640.00215912503812291
IRF4#3662417.53161014939532.08739444052064e-050.000460899340324598
JUN#3725410.01026335386910.0001908531347801070.00230593597215404
JUNB#3726424.48850612785695.54076322307085e-060.000167828239632917
JUND#372745.595731153496820.001849593301755460.0109351641574887
MAX#414945.16204440720570.002526309009485180.0140000629651715
MEF2A#4205414.99458472771523.876195075647e-050.000728104204146577
MXI1#460147.969257303007440.0004668546380070170.00429546573331115
MYC#460944.177825497287520.005691969036823440.0256854283717941
NFKB1#479044.390450739355070.004707732692524960.0222053515795598
NR3C1#2908411.97841866493849.4122920812787e-050.00136548183452794
PAX5#507945.335652424942260.002223389586187790.0127797790309227
POU2F2#545247.284899246194020.0006631223288743860.00542629733646572
PRDM1#6394105.4647646219691.63839404354338e-081.1899320967568e-06
RAD21#588548.284027116365060.0004011622639122450.00386753306385405
RFX5#599349.638328661756080.000221480125815720.00249715673756536
SIN3A#2594244.327107781452110.004977052855762880.0232467988910116
SMARCA4#65974125.412722646318.195036471498e-096.32113304318153e-07
SMARCC1#6599434.93068745570521.34857873968749e-065.3108678353779e-05
SMC3#9126412.03594627594639.2360978468394e-050.00134365346570004
SP1#666744.558705102512720.00407573565781680.0194875134535883
STAT1#6772416.56526999775942.61308619905866e-050.000563976254481271
STAT3#6774510.51946499715427.759040745861e-060.00022056245412547
TCF12#6938510.63446490218647.34844389925727e-060.000211248040846278
TCF7L2#693448.616141250509880.0003438969725982450.00347352571771645
TFAP2C#702248.647382887888180.0003390518878174050.00344893738304879
USF2#7392410.39375790805570.0001646179728687530.0020267047587457



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.