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Coexpression cluster:C2069

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Full id: C2069_CD14_Neutrophils_Peripheral_Eosinophils_Basophils_immature_CD14CD16



Phase1 CAGE Peaks

Hg19::chr10:70815943..70815956,-p@chr10:70815943..70815956
-
Hg19::chr11:47396114..47396124,-p@chr11:47396114..47396124
-
Hg19::chr9:132536258..132536280,+p@chr9:132536258..132536280
+
Hg19::chr9:132536282..132536289,+p@chr9:132536282..132536289
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
myeloid leukocyte1.24e-7476
classical monocyte1.07e-7245
CD14-positive, CD16-negative classical monocyte2.46e-7242
granulocyte monocyte progenitor cell5.25e-6571
leukocyte2.08e-61140
myeloid lineage restricted progenitor cell2.74e-5870
macrophage dendritic cell progenitor1.59e-5665
myeloid cell7.37e-54112
common myeloid progenitor7.37e-54112
monopoietic cell1.43e-5363
monocyte1.43e-5363
monoblast1.43e-5363
promonocyte1.43e-5363
hematopoietic stem cell2.83e-50172
angioblastic mesenchymal cell2.83e-50172
hematopoietic cell3.09e-46182
hematopoietic oligopotent progenitor cell6.66e-45165
hematopoietic multipotent progenitor cell6.66e-45165
hematopoietic lineage restricted progenitor cell8.81e-45124
nongranular leukocyte2.18e-41119
mesenchymal cell2.07e-20358
connective tissue cell1.49e-19365
motile cell7.85e-18390
intermediate monocyte2.80e-179
CD14-positive, CD16-positive monocyte2.80e-179
granulocyte8.22e-168
multi fate stem cell8.50e-15430
somatic stem cell2.94e-14436
stem cell3.44e-14444
blood cell5.72e-1111
histamine secreting cell2.68e-085
biogenic amine secreting cell2.68e-085
granulocytopoietic cell2.68e-085
mast cell2.68e-085
mast cell progenitor2.68e-085
basophil mast progenitor cell2.68e-085
mononuclear cell3.49e-073
neutrophil5.45e-073
immature conventional dendritic cell7.08e-075
common dendritic progenitor7.08e-075
basophil9.10e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.91e-69102
blood island8.91e-69102
hemolymphoid system8.52e-61112
bone marrow3.25e-6080
bone element8.71e-5786
skeletal element1.02e-45101
skeletal system1.02e-45101
immune system1.10e-42115
lateral plate mesoderm1.59e-25216
musculoskeletal system8.44e-25167
connective tissue2.20e-18375
blood1.17e-1015
haemolymphatic fluid1.17e-1015
organism substance1.17e-1015
mesoderm1.91e-08448
mesoderm-derived structure1.91e-08448
presumptive mesoderm1.91e-08448


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672210.09211532161190.0137713969900260.0484592631482926
FOS#235336.74846648167080.005032452776317940.0234520697651095
FOXA2#3170212.31523187633260.009361916285467240.0353335203432319
JUN#372539.384621894252250.001918994502030470.0112803437157404
JUND#372735.245997956403270.01043432751748420.0386614656259458
NR2C2#7182216.30730545262040.005411825344648220.024548541833292
PRDM1#639265.91547788873040.0003415175120768950.0034672642601146
SMARCB1#6598313.68953683586810.0006305783409379340.00517906349081605
SMARCC1#6599221.83167965981570.003051207456162050.0160901315583998
SMARCC2#6601247.07768721344880.0006669282967095870.00544890279121118
STAT1#6772210.35329374859960.01310777476171260.0464827302413671
TFAP2C#702238.106921457395170.002947011739866440.015713634507577



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.