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Coexpression cluster:C2144

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Full id: C2144_Basophils_CD14_Eosinophils_CD4_CD19_Natural_Mast



Phase1 CAGE Peaks

  Short description
Hg19::chr11:62323170..62323185,+ p@chr11:62323170..62323185
+
Hg19::chr12:13254352..13254403,+ +
p@chr12:13254352..13254403
Hg19::chr1:156076341..156076364,+ p22@LMNA
Hg19::chr8:145026443..145026482,+ p@chr8:145026443..145026482
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte8.32e-39136
hematopoietic stem cell1.45e-33168
angioblastic mesenchymal cell1.45e-33168
hematopoietic cell8.38e-33177
nongranular leukocyte5.93e-31115
hematopoietic lineage restricted progenitor cell8.19e-31120
classical monocyte9.17e-3142
CD14-positive, CD16-negative classical monocyte9.17e-3142
hematopoietic oligopotent progenitor cell1.39e-30161
hematopoietic multipotent progenitor cell1.39e-30161
myeloid leukocyte2.31e-2672
defensive cell9.54e-2648
phagocyte9.54e-2648
granulocyte monocyte progenitor cell4.36e-2467
macrophage dendritic cell progenitor1.68e-2161
myeloid lineage restricted progenitor cell7.91e-2166
myeloid cell2.55e-20108
common myeloid progenitor2.55e-20108
monopoietic cell3.18e-2059
monocyte3.18e-2059
monoblast3.18e-2059
promonocyte3.18e-2059
connective tissue cell1.70e-16361
mesenchymal cell4.88e-16354
motile cell2.99e-12386
stuff accumulating cell3.50e-1087
lymphocyte1.32e-0953
common lymphoid progenitor1.32e-0953
lymphoid lineage restricted progenitor cell2.61e-0952
nucleate cell8.61e-0955
multi fate stem cell9.53e-09427
stem cell1.17e-08441
intermediate monocyte1.35e-089
CD14-positive, CD16-positive monocyte1.35e-089
somatic stem cell1.87e-08433
Uber Anatomy
Ontology termp-valuen
bone element5.82e-2582
bone marrow9.12e-2476
skeletal element5.84e-2390
hematopoietic system2.33e-2298
blood island2.33e-2298
skeletal system5.45e-19100
hemolymphoid system3.81e-18108
immune system1.15e-1793
connective tissue7.90e-16371
lateral plate mesoderm7.45e-07203


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.0360116317477163
BCL11A#53335214.18472755180350.007108328585298740.0296125540135626
BCL3#602217.27355140186920.004834494208076070.0226691393434767
EBF1#187936.679850134926750.005184294118278910.0240320680612042
ELF1#199744.258097958807540.003041525565781240.0160552887826448
EP300#203335.08045629466740.01144298405398240.041869944000766
IRF4#3662210.95725634337210.01174530180688030.0428141277934025
MAX#414946.452555509007120.0005767613195645490.00484487858553864
MXI1#460137.471178721569470.003741314738550960.0186217018529058
NR3C1#2908311.22976749837980.001131672068063850.00775224315338586
PAX5#507935.002174148383370.01196533174786410.0434720407157579
POU2F2#545236.829593043306890.004860473775203740.0227521411235939
RXRA#6256210.03730856956660.01391703805920110.0488696637033455



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.