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Coexpression cluster:C2152: Difference between revisions

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|full_id=C2152_Basophils_CD34_Natural_CD4_CD14_CD8_Dendritic
|full_id=C2152_Basophils_CD34_Natural_CD4_CD14_CD8_Dendritic
|id=C2152
|id=C2152
|ontology_enrichment_celltype=CL:0000738!1.65e-42!140;CL:0002031!1.01e-36!124;CL:0002087!2.58e-35!119;CL:0000037!8.74e-33!172;CL:0000566!8.74e-33!172;CL:0000988!1.11e-31!182;CL:0002032!5.19e-30!165;CL:0000837!5.19e-30!165;CL:0000766!5.22e-21!76;CL:0002057!1.46e-19!42;CL:0000860!4.11e-19!45;CL:0000557!3.22e-18!71;CL:0000839!5.32e-18!70;CL:0002009!2.15e-17!65;CL:0000838!4.05e-17!52;CL:0000542!6.82e-17!53;CL:0000051!6.82e-17!53;CL:0002194!2.30e-16!63;CL:0000576!2.30e-16!63;CL:0000040!2.30e-16!63;CL:0000559!2.30e-16!63;CL:0000763!8.74e-14!112;CL:0000049!8.74e-14!112;CL:0000791!2.43e-10!18;CL:0000789!2.43e-10!18;CL:0002420!2.43e-10!18;CL:0002419!2.43e-10!18;CL:0000790!2.43e-10!18;CL:0000134!1.58e-09!358;CL:0002320!5.82e-09!365;CL:0000945!2.04e-08!24;CL:0000826!2.04e-08!24;CL:0000084!3.66e-08!25;CL:0000827!3.66e-08!25;CL:0000625!2.46e-07!11
|ontology_enrichment_celltype=CL:0000738!1.54e-39!136;CL:0002031!9.68e-32!120;CL:0002087!6.54e-31!115;CL:0000988!8.75e-29!177;CL:0000037!1.51e-28!168;CL:0000566!1.51e-28!168;CL:0002032!3.12e-24!161;CL:0000837!3.12e-24!161;CL:0000838!1.98e-18!52;CL:0000542!7.42e-18!53;CL:0000051!7.42e-18!53;CL:0000766!6.98e-17!72;CL:0002242!8.91e-17!55;CL:0000557!4.63e-14!67;CL:0002009!1.80e-12!61;CL:0000839!2.44e-12!66;CL:0002194!3.89e-11!59;CL:0000576!3.89e-11!59;CL:0000040!3.89e-11!59;CL:0000559!3.89e-11!59;CL:0000860!1.14e-10!42;CL:0002057!1.14e-10!42;CL:0000473!2.92e-10!48;CL:0000234!2.92e-10!48;CL:0000763!5.45e-09!108;CL:0000049!5.45e-09!108;CL:0000791!6.12e-09!18;CL:0000789!6.12e-09!18;CL:0002420!6.12e-09!18;CL:0002419!6.12e-09!18;CL:0000790!6.12e-09!18;CL:0000624!6.95e-09!6;CL:0000945!1.87e-08!24;CL:0000826!1.87e-08!24;CL:0000084!2.06e-08!25;CL:0000827!2.06e-08!25;CL:0000134!3.04e-08!354;CL:0002393!3.56e-08!9;CL:0002397!3.56e-08!9;CL:0002320!5.47e-08!361;CL:0000080!5.93e-08!6
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002390!2.54e-19!102;UBERON:0003061!2.54e-19!102;UBERON:0002193!1.20e-17!112;UBERON:0002371!2.56e-15!80;UBERON:0001474!1.27e-13!86;UBERON:0002405!6.48e-12!115;UBERON:0004765!5.97e-11!101;UBERON:0001434!5.97e-11!101;UBERON:0002384!3.57e-08!375
|ontology_enrichment_uberon=UBERON:0002390!4.08e-16!98;UBERON:0003061!4.08e-16!98;UBERON:0002193!1.48e-15!108;UBERON:0002405!2.11e-13!93;UBERON:0002371!8.34e-13!76;UBERON:0001474!8.10e-12!82;UBERON:0004765!4.42e-11!90;UBERON:0001434!8.46e-09!100;UBERON:0002384!1.89e-07!371
|tf_chipseq_enrich=BRCA1#672;2:10.0921153216119:0.013771396990026:0.0484625288173504!JUND#3727;3:5.24599795640327:0.0104343275174842:0.038668324873981!NFKB1#4790;4:5.48806342419384:0.00110219956630198:0.00766599763618888!NR2C2#7182;2:16.3073054526204:0.00541182534464822:0.0245496080949362!POU2F2#5452;4:9.10612405774252:0.00014539566517493:0.00188119151080333!SMARCC2#6601;2:47.0776872134488:0.000666928296709587:0.0054493290862191
|tf_chipseq_enrich=BRCA1#672;2:10.0921153216119:0.013771396990026:0.0484625288173504!JUND#3727;3:5.24599795640327:0.0104343275174842:0.038668324873981!NFKB1#4790;4:5.48806342419384:0.00110219956630198:0.00766599763618888!NR2C2#7182;2:16.3073054526204:0.00541182534464822:0.0245496080949362!POU2F2#5452;4:9.10612405774252:0.00014539566517493:0.00188119151080333!SMARCC2#6601;2:47.0776872134488:0.000666928296709587:0.0054493290862191
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6228,0.271849,0.282657,0.105411,0.0997542,0.209692,0.248936,0.0725263,0.102587,0.0742013,0.0552936,0.0457886,0.0514927,0.0593965,0.220368,0.258624,0.064656,0.226143,0.12751,0.0438521,0.00283228,0.0439557,0.0522771,0.0787278,0.164404,0.159873,0.142462,0.143935,0.332403,0.0379537,0.00471564,0.187953,0.051459,0.114868,0.0726892,0.18732,0.32305,0.278397,0.245002,0.170848,0.487259,0.051371,0.363016,0.0051954,0.223102,0.107653,0.0303023,0.103852,0.0197215,0.184022,0.216557,0.182956,0.116818,0.389792,0.36316,0.0625685,0.124464,0.186295,0.173134,0.101893,0.142875,0.167635,0.171311,0.0721023,0.189107,0.0685131,0.130287,0.0661526,0.0815772,0.0993937,0.122878,0.187329,0.0451012,0.0976639,0.351199,0.0102393,0.758305,0.278645,0.0769795,0.155708,0.248017,0.22995,0.285695,0.0760151,0.0629459,6.84901e-05,0.0803251,0.226641,0.0832234,0.0939463,0.286748,0.367925,0.0471607,0.163865,0.226359,0.22476,0.165788,0.000294622,0.279778,0.141699,0.0887743,0.142302,0.0653269,0.125712,0.264432,0.0994829,0.0604041,0.144185,0.0925862,0.289561,0.199201,0.049937,0.172796,0.0595495,0.071232,0.149346,0.121978,0.22302,0.137423,0.0448074,0.0754883,0.299492,0.100006,0.0756617,0.197817,0.0345492,0.279874,0.133127,0.410303,0.223717,0.426452,0.196838,0.0826805,0.246601,0.193021,0.240896,0.202165,0.0946865,0.120618,0.079499,0.18762,0.195618,0.00852312,0.0217469,0.0262879,0.034089,0.178639,0.291976,0.320355,0.364334,0.15547,0.110256,0.101581,0.14794,0.147307,0.240761,0.0277041,0.124417,0.335582,0.317428,0.182843,0.130771,0.327768,0.135777,0.147842,0.0339286,0.217363,0.00738129,0.690952,0.21618,0.243266,0.107021,0.238657,0.20272,0.392453,0.0724243,0.0780061,0.315336,0.230477,0.279823,0.295555,0.502112,0.0420826,0.0478217,0.0351792,0.170854,0.0575231,0.174063,0.514243,0.459091,0.0466753,0.502211,0.296013,0.649813,0.537932,0.459994,0.523209,0.548059,0.25423,0.490559,0.45013,0.500698,0.472542,0.322168,0.399934,0.529642,0.244786,0.483077,0.061678,0.603763,0.541914,0.627201,0.14959,0.514482,0.290703,0.254935,0.722684,0.00448166,0.360199,0.241059,0.657141,0.253797,0.365494,0.212703,0.56318,0.364079,0.107716,0.0575699,0.421038,0.569409,0.328518,0.545608,0.310552,0.143396,0.483764,0.528161,0.453065,0.209437,0.11765,0.0514874,0.232518,0.0662179,0.464001,0.0572812,0.0572388,0.0565519,0.278028,0.137711,0.261575,0.257956,0.264245,0.379063,5.79466e-05,0.522925,0.436016,0.136753,0.202522,0.183837,0.507324,0.126097,0.3955,0.442469,0.212239,0.048546,0.156999,0.35974,0.025886,0.39549,0.234254,0.073225,0.146291,0.137737,0.50338,0.620526,0.404625,0.172147,0.424691,0.715362,0.479581,0.62689,0.00679433,0.642173,0.284496,0.512545,0.512178,0.0515768,0.527709,0.110875,0.263302,0.552023,0.180735,0.189249,0.216102,0.254659,0.109605,0.397869,0.582542,0.226491,0.417131,0.463987,0.260097,0.503881,0.124057,0.271678,0.483658,0.452129,0.301581,0.0376831,0.346776,0.131322,0.187223,0.438176,0.0696091,0.741477,0.0862349,0.307816,0.128211,0.386339,0.0131065,0.598787,0.478745,0.24434,0.319747,0.136743,0.557967,0.608127,0.282281,0.0710918,0.2536,0.246827,0.564333,0.347466,0.387134,0.559969,0.358813,0.303004,0.574252,0.493455,0.346636,0.457747,0.348802,0.476541,0.579645,0.447581,0.42505,0.254628,0.131374,0.479347,0.416962,0.264955,0.378333,0.738545,0.264038,0.22798,0.102495,0.350933,0.263896,0.0446972,0.24452,0.329284,0.242783,0.0947248,0.336551,0.210656,0.246234,0.211271,0.281295,0.267248,0.118257,0.125087,0.215123,0.321224,0.469461,0.325254,0.266651,0.546295,0.231754,0.249415,0.283107,0.285648,0.10809,0.391071,0.279553,0.25563,0.240967,0.160955,0.256687,0.0432189,0.122439,0.16188,0.23235,0.0469743,0.353147,0.112422,0.170886,0.267687,0.0560879,0.284866,0.0887542,0.267811,0.338547,0.147872,0.189388,0.293546,0.210125,0.292967,0.218414,0.0509944,0.0871471,0.0689852,0.0602698,0.341188,0.259328,0.437467,0.201057,0.15696,0.129351,0.141936,0.0786166,0.276997,0.0227344,0.282389,0.251421,0.162089,0.330223,0.387837,0.233244,0.207281,0.0606443,0.195748,0.27845,0.161712,0.237871,0.239139,0.095257,0.328852,0.332769,0.0377937,0.274403,0.266687,0.184534,0.248707,0.31749,0.15156,0.287598,0.313858,0.223773,0.25788,0.181895,0.253768,0.30702,0.202977,0.170837,0.327002,0.0452813,0.222656,0.228479,0.127111,0.259989,0.390754,0.355805,0.279739,0.108118,0.259901,0.139723,0.0708274,0.0710478,0.196248,0.102645,0.0539258,0.0709978,0.401939,0.332746,0.271338,0.242121,0.298673,0.244395,0.106889,0.128632,0.0845989,0.159153,0.00365225,0.13698,0.0874421,0.100355,0.167854,0.142846,0.0583767,0.088258,0.117657,0.0486914,0.175784,0.262778,0.373453,0.362662,0.433518,0.184359,0.334474,0.325785,0.257476,0.291176,0.376537,0.0588457,0.229571,0.359036,0.335984,0.171704,0.208256,0.265058,0.256405,0.0756763,0.302133,0.40806,0.151361,0.279606,0.286696,0.150674,0.251128,0.246177,0.35674,0.35852,0.318525,0.213257,0.287217,0.122782,0.410951,0.289049,0.266974,0.125746,0.112897,0.398354,0.222091,0.205977,0.34423,0.0936726,0.343425,0.132374,0.285122,0.22741,0.203996,0.276721,0.321965,0.264707,0.450113
}}
}}

Revision as of 12:07, 19 October 2012


Full id: C2152_Basophils_CD34_Natural_CD4_CD14_CD8_Dendritic



Phase1 CAGE Peaks

Hg19::chr11:64902087..64902104,+p@chr11:64902087..64902104
+
Hg19::chr11:64902110..64902119,+p@chr11:64902110..64902119
+
Hg19::chr16:11877482..11877499,-p@chr16:11877482..11877499
-
Hg19::chr22:37518536..37518543,+p@chr22:37518536..37518543
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.54e-39136
hematopoietic lineage restricted progenitor cell9.68e-32120
nongranular leukocyte6.54e-31115
hematopoietic cell8.75e-29177
hematopoietic stem cell1.51e-28168
angioblastic mesenchymal cell1.51e-28168
hematopoietic oligopotent progenitor cell3.12e-24161
hematopoietic multipotent progenitor cell3.12e-24161
lymphoid lineage restricted progenitor cell1.98e-1852
lymphocyte7.42e-1853
common lymphoid progenitor7.42e-1853
myeloid leukocyte6.98e-1772
nucleate cell8.91e-1755
granulocyte monocyte progenitor cell4.63e-1467
macrophage dendritic cell progenitor1.80e-1261
myeloid lineage restricted progenitor cell2.44e-1266
monopoietic cell3.89e-1159
monocyte3.89e-1159
monoblast3.89e-1159
promonocyte3.89e-1159
classical monocyte1.14e-1042
CD14-positive, CD16-negative classical monocyte1.14e-1042
defensive cell2.92e-1048
phagocyte2.92e-1048
myeloid cell5.45e-09108
common myeloid progenitor5.45e-09108
mature alpha-beta T cell6.12e-0918
alpha-beta T cell6.12e-0918
immature T cell6.12e-0918
mature T cell6.12e-0918
immature alpha-beta T cell6.12e-0918
CD4-positive, alpha-beta T cell6.95e-096
lymphocyte of B lineage1.87e-0824
pro-B cell1.87e-0824
T cell2.06e-0825
pro-T cell2.06e-0825
mesenchymal cell3.04e-08354
intermediate monocyte3.56e-089
CD14-positive, CD16-positive monocyte3.56e-089
connective tissue cell5.47e-08361
circulating cell5.93e-086
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.08e-1698
blood island4.08e-1698
hemolymphoid system1.48e-15108
immune system2.11e-1393
bone marrow8.34e-1376
bone element8.10e-1282
skeletal element4.42e-1190
skeletal system8.46e-09100
connective tissue1.89e-07371


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672210.09211532161190.0137713969900260.0484625288173504
JUND#372735.245997956403270.01043432751748420.038668324873981
NFKB1#479045.488063424193840.001102199566301980.00766599763618888
NR2C2#7182216.30730545262040.005411825344648220.0245496080949362
POU2F2#545249.106124057742520.000145395665174930.00188119151080333
SMARCC2#6601247.07768721344880.0006669282967095870.0054493290862191



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.