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Coexpression cluster:C2264

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Full id: C2264_occipital_parietal_pineal_temporal_duodenum_brain_optic



Phase1 CAGE Peaks

  Short description
Hg19::chr13:44361004..44361022,- p3@ENOX1
Hg19::chr13:44361025..44361052,- p1@ENOX1
Hg19::chr13:44361058..44361095,- p2@ENOX1
Hg19::chr13:44361100..44361121,- p4@ENOX1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
fibroblast2.18e-0976
muscle precursor cell1.61e-0758
myoblast1.61e-0758
multi-potent skeletal muscle stem cell1.61e-0758
muscle cell2.17e-0755
electrically responsive cell2.93e-0761
electrically active cell2.93e-0761
Uber Anatomy
Ontology termp-valuen
nervous system7.22e-2789
neural tube1.50e-2656
neural rod1.50e-2656
future spinal cord1.50e-2656
neural keel1.50e-2656
structure with developmental contribution from neural crest1.46e-25132
central nervous system4.95e-2581
regional part of nervous system6.53e-2553
regional part of brain6.53e-2553
neural plate3.89e-2382
presumptive neural plate3.89e-2382
brain5.66e-2368
future brain5.66e-2368
regional part of forebrain3.56e-2241
forebrain3.56e-2241
anterior neural tube3.56e-2241
future forebrain3.56e-2241
multi-tissue structure5.75e-22342
ectoderm-derived structure2.89e-21171
ectoderm2.89e-21171
presumptive ectoderm2.89e-21171
neurectoderm8.32e-2186
ecto-epithelium8.99e-21104
adult organism2.22e-20114
organ system subdivision2.53e-20223
anatomical cluster5.33e-20373
cell layer3.09e-19309
epithelium5.31e-19306
telencephalon5.51e-1934
brain grey matter6.18e-1934
gray matter6.18e-1934
regional part of telencephalon1.06e-1732
cerebral hemisphere1.07e-1732
pre-chordal neural plate1.26e-1661
regional part of cerebral cortex3.23e-1422
tube4.01e-14192
multi-cellular organism1.01e-13656
cerebral cortex1.85e-1325
pallium1.85e-1325
anatomical system3.20e-13624
neocortex3.29e-1320
anatomical group5.92e-13625
embryonic structure1.57e-12564
germ layer1.57e-12560
germ layer / neural crest1.57e-12560
embryonic tissue1.57e-12560
presumptive structure1.57e-12560
germ layer / neural crest derived structure1.57e-12560
epiblast (generic)1.57e-12560
anatomical conduit2.87e-12240
embryo1.17e-10592
dense mesenchyme tissue2.56e-1073
developing anatomical structure3.18e-10581
paraxial mesoderm5.72e-1072
presumptive paraxial mesoderm5.72e-1072
organ part1.04e-09218
somite1.58e-0971
presomitic mesoderm1.58e-0971
presumptive segmental plate1.58e-0971
dermomyotome1.58e-0971
trunk paraxial mesoderm1.58e-0971
muscle tissue3.12e-0964
musculature3.12e-0964
musculature of body3.12e-0964
skeletal muscle tissue7.56e-0962
striated muscle tissue7.56e-0962
myotome7.56e-0962
multilaminar epithelium1.14e-0783
tissue2.99e-07773
organ3.51e-07503
neural nucleus5.14e-079
nucleus of brain5.14e-079
basal ganglion7.36e-079
nuclear complex of neuraxis7.36e-079
aggregate regional part of brain7.36e-079
collection of basal ganglia7.36e-079
cerebral subcortex7.36e-079
epithelial vesicle7.61e-0778


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00816227737713611
E2F1#186944.907389214879320.001724022357361790.0106321329188372
RAD21#5885410.35503389545638.6948481184721e-050.00129153924426839
REST#597849.650028716128020.0001152825614219170.00156832036372849



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.