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Coexpression cluster:C2495

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Full id: C2495_Neutrophils_CD14_Eosinophils_immature_Natural_CD8_Peripheral



Phase1 CAGE Peaks

Hg19::chr19:49378898..49378909,+p@chr19:49378898..49378909
+
Hg19::chr1:184942789..184942813,-p@chr1:184942789..184942813
-
Hg19::chr21:46294651..46294656,+p@chr21:46294651..46294656
+
Hg19::chr9:95895999..95896035,-p@chr9:95895999..95896035
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte3.95e-65136
classical monocyte6.28e-6042
CD14-positive, CD16-negative classical monocyte6.28e-6042
myeloid leukocyte3.71e-5972
hematopoietic stem cell9.36e-52168
angioblastic mesenchymal cell9.36e-52168
defensive cell3.06e-5148
phagocyte3.06e-5148
granulocyte monocyte progenitor cell1.38e-4867
hematopoietic cell2.40e-48177
hematopoietic lineage restricted progenitor cell4.63e-48120
nongranular leukocyte1.77e-46115
macrophage dendritic cell progenitor1.24e-4561
hematopoietic oligopotent progenitor cell7.92e-45161
hematopoietic multipotent progenitor cell7.92e-45161
myeloid lineage restricted progenitor cell7.88e-4466
monopoietic cell1.08e-4159
monocyte1.08e-4159
monoblast1.08e-4159
promonocyte1.08e-4159
myeloid cell1.12e-39108
common myeloid progenitor1.12e-39108
stuff accumulating cell4.32e-2487
mesenchymal cell1.86e-16354
granulocyte2.09e-168
connective tissue cell7.68e-16361
motile cell2.10e-14386
blood cell1.31e-1111
multi fate stem cell4.91e-11427
somatic stem cell1.13e-10433
stem cell3.32e-10441
neutrophil1.77e-093
natural killer cell5.01e-093
pro-NK cell5.01e-093
single nucleate cell8.81e-093
mononuclear cell8.81e-093
basophil1.70e-083
Uber Anatomy
Ontology termp-valuen
bone marrow4.63e-4476
bone element4.53e-4082
hematopoietic system4.90e-4098
blood island4.90e-4098
skeletal element1.42e-3590
hemolymphoid system2.91e-35108
immune system4.37e-3493
skeletal system5.81e-31100
lateral plate mesoderm3.03e-15203
connective tissue5.32e-15371
musculoskeletal system2.11e-14167
mesoderm4.77e-08315
mesoderm-derived structure4.77e-08315
presumptive mesoderm4.77e-08315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.45381
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.12.82503
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.11.68681
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.11.8408
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.11.90157
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.481
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.21.37305
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.533581
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.11.37853
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.476674
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.0360181226690839
BCL11A#53335321.27709132770530.0001704839114606140.00208125882279778
BCLAF1#9774210.82632380506090.01202203816432580.0436552847204207
CEBPB#105135.978360719368610.007153832484726970.0297285974404106
CHD2#110637.758017125587640.003351522464536340.0172973737237454
JUND#372735.245997956403270.01043432751748420.0386930383325711
TFAP2A#7020312.38897577978370.000846941303588430.00638009974072937
TFAP2C#702238.106921457395170.002947011739866440.0157168441556407



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.