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Coexpression cluster:C253

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Full id: C253_spleen_rhabdomyosarcoma_Hepatocyte_small_uterus_liver_rectum



Phase1 CAGE Peaks

Hg19::chr10:102890846..102890877,+p2@TLX1
Hg19::chr10:102890890..102890902,-p1@TLX1NB
Hg19::chr10:102891023..102891028,+p7@TLX1
Hg19::chr10:102891044..102891047,+p6@TLX1
Hg19::chr10:102891048..102891078,+p1@TLX1
Hg19::chr10:102891168..102891197,+p3@TLX1
Hg19::chr10:102900211..102900229,-p@chr10:102900211..102900229
-
Hg19::chr10:125823416..125823426,-p@chr10:125823416..125823426
-
Hg19::chr11:114042566..114042569,+p@chr11:114042566..114042569
+
Hg19::chr11:56859603..56859606,-p@chr11:56859603..56859606
-
Hg19::chr11:56859608..56859619,-p@chr11:56859608..56859619
-
Hg19::chr11:56859638..56859643,-p@chr11:56859638..56859643
-
Hg19::chr11:56859693..56859701,-p@chr11:56859693..56859701
-
Hg19::chr11:56859722..56859732,-p@chr11:56859722..56859732
-
Hg19::chr11:72350972..72350982,+p@chr11:72350972..72350982
+
Hg19::chr11:72350992..72351010,+p@chr11:72350992..72351010
+
Hg19::chr11:925438..925445,+p20@AP2A2
Hg19::chr12:103981044..103981061,+p1@STAB2
Hg19::chr12:52809084..52809091,+p@chr12:52809084..52809091
+
Hg19::chr14:73702509..73702520,+p@chr14:73702509..73702520
+
Hg19::chr15:101999172..101999221,-p@chr15:101999172..101999221
-
Hg19::chr15:94899150..94899178,+p5@MCTP2
Hg19::chr15:94899183..94899200,+p7@MCTP2
Hg19::chr15:95561320..95561328,-p@chr15:95561320..95561328
-
Hg19::chr15:95561338..95561347,-p@chr15:95561338..95561347
-
Hg19::chr15:95561349..95561361,-p@chr15:95561349..95561361
-
Hg19::chr16:199450..199454,+p@chr16:199450..199454
+
Hg19::chr16:70624024..70624042,+p@chr16:70624024..70624042
+
Hg19::chr16:84218794..84218800,+p@chr16:84218794..84218800
+
Hg19::chr17:78171885..78171900,+p@chr17:78171885..78171900
+
Hg19::chr19:17729847..17729880,-p5@UNC13A
Hg19::chr19:32401253..32401271,-p@chr19:32401253..32401271
-
Hg19::chr19:32401274..32401289,-p@chr19:32401274..32401289
-
Hg19::chr19:496478..496490,+p3@MADCAM1
Hg19::chr1:159172187..159172197,-p1@uc001ftm.1
Hg19::chr1:28520450..28520453,-p21@PTAFR
Hg19::chr1:91921807..91921821,+p@chr1:91921807..91921821
+
Hg19::chr21:40459334..40459341,+p@chr21:40459334..40459341
+
Hg19::chr2:96922657..96922663,-p@chr2:96922657..96922663
-
Hg19::chr3:130267501..130267516,+p@chr3:130267501..130267516
+
Hg19::chr3:183145802..183145813,-p23@MCF2L2
Hg19::chr3:46505111..46505126,-p3@LTF
Hg19::chr4:53811826..53811839,+p1@ENST00000504048
Hg19::chr4:53811852..53811859,+p1@ENST00000508813
Hg19::chr5:51986615..51986645,+p@chr5:51986615..51986645
+
Hg19::chr6:104674595..104674600,-p@chr6:104674595..104674600
-
Hg19::chr6:119812455..119812476,-p1@uc003pyn.1
Hg19::chr7:4051097..4051112,+p@chr7:4051097..4051112
+
Hg19::chr9:127267269..127267274,-p@chr9:127267269..127267274
-
Hg19::chr9:139553306..139553309,+p7@EGFL7
Hg19::chr9:35700153..35700160,-p@chr9:35700153..35700160
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0048646anatomical structure formation0.00193832272984478
GO:0010324membrane invagination0.00193832272984478
GO:0006897endocytosis0.00193832272984478
GO:0016044membrane organization and biogenesis0.00431743742458901
GO:0009887organ morphogenesis0.00708308593722784
GO:0048645organ formation0.0117210525475664
GO:0042742defense response to bacterium0.0117210525475664
GO:0009617response to bacterium0.0117210525475664
GO:0002376immune system process0.0117210525475664
GO:0008289lipid binding0.0117210525475664
GO:0006952defense response0.0117210525475664
GO:0016188synaptic vesicle maturation0.0117210525475664
GO:0016192vesicle-mediated transport0.0117210525475664
GO:0001525angiogenesis0.0117210525475664
GO:0048514blood vessel morphogenesis0.0141790158821224
GO:0008368Gram-negative bacterial binding0.0143462514971166
GO:0001568blood vessel development0.0150345560599335
GO:0001944vasculature development0.0150345560599335
GO:0048536spleen development0.0153006412809464
GO:0004992platelet activating factor receptor activity0.0153006412809464
GO:0030128clathrin coat of endocytic vesicle0.0166289289310239
GO:0030669clathrin-coated endocytic vesicle membrane0.0166289289310239
GO:0030122AP-2 adaptor complex0.0166289289310239
GO:0051707response to other organism0.0170203211293769
GO:0030666endocytic vesicle membrane0.0170203211293769
GO:0048488synaptic vesicle endocytosis0.0170203211293769
GO:0007242intracellular signaling cascade0.0170203211293769
GO:0045334clathrin-coated endocytic vesicle0.0191182028028224
GO:0019932second-messenger-mediated signaling0.0239916635361042
GO:0009653anatomical structure morphogenesis0.0240215820592173
GO:0044459plasma membrane part0.0240215820592173
GO:0009607response to biotic stimulus0.0240215820592173
GO:0005041low-density lipoprotein receptor activity0.0240215820592173
GO:0030228lipoprotein receptor activity0.0240215820592173
GO:0008367bacterial binding0.0240215820592173
GO:0048513organ development0.0268474818617303
GO:0030132clathrin coat of coated pit0.0268474818617303
GO:0051704multi-organism process0.0280011431313333
GO:0006955immune response0.0284436603857437
GO:0016050vesicle organization and biogenesis0.0298074971666347
GO:0015035protein disulfide oxidoreductase activity0.0298074971666347
GO:0050435beta-amyloid metabolic process0.0301934221657316
GO:0030169low-density lipoprotein binding0.0301934221657316
GO:0048489synaptic vesicle transport0.0305445938335891
GO:0001570vasculogenesis0.0305445938335891
GO:0015036disulfide oxidoreductase activity0.034266593798573
GO:0030125clathrin vesicle coat0.034266593798573
GO:0030139endocytic vesicle0.034266593798573
GO:0016846carbon-sulfur lyase activity0.034266593798573
GO:0030665clathrin coated vesicle membrane0.0351030347467773
GO:0008034lipoprotein binding0.0433580422000358
GO:0005540hyaluronic acid binding0.0439847633389143
GO:0048731system development0.048251523533826
GO:0007165signal transduction0.0493670822384186



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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