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Coexpression cluster:C2586: Difference between revisions

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|ontology_enrichment_disease=DOID:162!1.58e-31!235;DOID:14566!3.14e-30!239;DOID:0050686!7.05e-16!137;DOID:2531!1.01e-14!51;DOID:0060083!1.01e-14!51;DOID:0050687!1.64e-14!143;DOID:1240!2.45e-12!39;DOID:305!1.59e-11!106;DOID:8692!1.34e-09!31
|ontology_enrichment_disease=DOID:162!1.58e-31!235;DOID:14566!3.14e-30!239;DOID:0050686!7.05e-16!137;DOID:2531!1.01e-14!51;DOID:0060083!1.01e-14!51;DOID:0050687!1.64e-14!143;DOID:1240!2.45e-12!39;DOID:305!1.59e-11!106;DOID:8692!1.34e-09!31
|ontology_enrichment_uberon=UBERON:0003104!1.45e-07!238;UBERON:0009142!1.45e-07!238;UBERON:0000487!5.53e-07!22;UBERON:0000072!6.93e-07!46
|ontology_enrichment_uberon=UBERON:0003104!1.45e-07!238;UBERON:0009142!1.45e-07!238;UBERON:0000487!5.53e-07!22;UBERON:0000072!6.93e-07!46
|tf_chipseq_enrich=BRCA1#672;3:15.1381729824178:0.000468218442143119:0.00430232851301999!CHD2#1106;3:7.75801712558764:0.00335152246453634:0.017300793528752!E2F4#1874;3:9.50104523646333:0.00185075103472827:0.0109296345669203!EP300#2033;3:5.0804562946674:0.0114429840539824:0.0418993027246035!ETS1#2113;3:7.29657069165175:0.0040085737751139:0.0192068374775942!FOS#2353;3:6.7484664816708:0.00503245277631794:0.0234709210693462!GABPB1#2553;3:5.30076287713663:0.0101267882423427:0.037864515152586!HDAC2#3066;3:10.0617151774697:0.0015637275447474:0.00992489462448336!IRF1#3659;3:5.72787281517293:0.00809711479033333:0.0320117565048121!IRF3#3661;3:35.2364641586172:3.79279212646878e-05:0.000720078925461322!MAX#4149;3:4.83941663175534:0.0131573713783684:0.0466301099251896!MXI1#4601;3:7.47117872156947:0.00374131473855096:0.018635912146684!NFYA#4800;3:13.8191855248729:0.000613241180673451:0.00508828916090844!NFYB#4801;3:12.5698449401523:0.00081145639769735:0.00619002956096075!PAX5#5079;3:5.00217414838337:0.0119653317478641:0.0435038218421297!POU2F2#5452;3:6.82959304330689:0.00486047377520374:0.0227643849772861!SP2#6668;3:19.6151478703835:0.000217100426924534:0.00248642959618065!TAF7#6879;3:8.57480205369294:0.0025005543351524:0.0140360848225831!ZBTB33#10009;3:23.7485437724859:0.000122945190881838:0.00165574117221255
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0997542,0.209692,0.248936,0.0725263,0.102587,0.0742013,0.0552936,0.0457886,0.0514927,0.0593965,0.220368,0.258624,0.064656,0.226143,0.460406,0.0438521,0.435508,0.281453,0.0522771,0.0787278,0.515487,0.159873,0.142462,0.143935,0.332403,0.0379537,0.6545,0.187953,0.051459,0.000276381,0.0726892,0.18732,0.32305,0.278397,0.245002,0.170848,0.487259,0.302909,7.95404e-06,0.100188,0.223102,0.107653,0.235857,0.419621,0.0197215,0.184022,0.216557,0.182956,0.116818,0.389792,0.36316,0.0625685,0.124464,0.544477,0.173134,0.101893,0.142875,0.167635,0.171311,0.458838,0.548036,0.0685131,0.130287,0.0661526,0.0815772,0.0993937,0.122878,0.187329,0.0451012,0.0976639,0.351199,0.833813,0.758305,0.278645,0.365775,0.155708,0.248017,0.22995,0.285695,0.0760151,0.0629459,0.486024,0.0803251,0.226641,0.379174,0.0939463,0.286748,0.367925,0.0471607,0.163865,0.226359,0.00188396,0.709625,0.265324,0.279778,0.141699,0.0887743,0.142302,0.0653269,0.125712,0.264432,0.0994829,0.0604041,0.144185,0.0925862,0.289561,0.199201,0.049937,0.172796,0.0595495,0.071232,0.149346,0.121978,0.22302,0.137423,0.284016,0.0754883,0.299492,0.100006,0.362866,0.197817,0.251078,0.279874,0.133127,0.410303,0.0271325,0.426452,0.196838,0.0826805,0.246601,0.0199582,0.608002,0.202165,0.0946865,0.120618,0.079499,0.18762,0.195618,0.127688,0.201169,0.220353,0.24948,0.178639,0.291976,0.320355,0.364334,0.15547,0.110256,0.415419,0.14794,0.147307,0.240761,0.225961,0.124417,0.335582,0.317428,0.182843,0.130771,0.327768,0.135777,0.147842,0.0339286,0.217363,0.119015,0.690952,0.21618,0.243266,0.107021,0.238657,0.0220967,0.392453,0.61565,0.0780061,0.315336,0.230477,0.279823,0.295555,0.502112,0.724669,0.0478217,0.507599,0.170854,0.0575231,0.174063,0.0368787,0.459091,0.54832,0.502211,0.296013,0.649813,0.181196,0.459994,0.523209,0.548059,0.25423,0.490559,0.45013,0.500698,0.135135,0.685908,0.747471,0.174869,0.818701,0.483077,0.590496,0.603763,0.184287,0.627201,0.00233402,0.757308,0.290703,0.622694,0.722684,0.478691,0.360199,0.608176,0.657141,0.519564,0.365494,0.212703,0.56318,0.364079,0.680099,0.579886,0.421038,0.569409,0.328518,0.545608,0.310552,0.0529131,0.483764,0.528161,0.453065,0.209437,0.55323,0.748403,0.232518,0.630688,0.464001,0.0184382,0.0019793,0.0181398,0.0387841,0.0155453,0.261575,0.257956,0.264245,0.379063,0.326516,0.0069676,0.436016,0.475063,0.202522,0.183837,0.507324,0.126097,0.0146433,0.442469,0.212239,0.294954,0.000730838,0.35974,0.301684,0.39549,0.234254,0.357409,0.599068,0.365184,0.50338,0.620526,0.404625,0.172147,0.424691,0.715362,0.479581,0.0181348,4.87946e-07,0.642173,0.284496,0.512545,0.512178,0.563206,0.260945,0.321001,0.263302,0.552023,0.180735,0.0646927,0.216102,0.254659,0.109605,0.397869,0.582542,0.226491,0.417131,0.463987,0.627953,0.503881,0.454761,0.639483,0.483658,0.452129,0.301581,0.261657,0.00938391,0.466529,0.187223,0.438176,0.349112,0.155207,0.385425,0.307816,0.461541,0.386339,0.382854,0.598787,0.478745,0.611661,0.319747,0.475047,0.0498053,0.608127,0.282281,0.612712,0.2536,0.246827,0.564333,0.70712,0.387134,0.559969,0.358813,0.100705,0.574252,0.493455,0.346636,0.457747,0.348802,0.476541,0.579645,0.447581,0.42505,0.254628,0.713293,0.479347,0.416962,0.264955,0.378333,0.738545,0.264038,0.22798,0.102495,0.350933,0.263896,0.0446972,0.24452,0.329284,0.242783,0.0947248,0.336551,0.210656,0.246234,0.211271,0.281295,0.267248,0.118257,0.125087,0.215123,0.321224,0.469461,0.325254,0.266651,0.546295,0.231754,0.249415,0.283107,0.285648,0.427316,0.391071,0.279553,0.25563,0.240967,0.160955,0.256687,0.0432189,0.122439,0.16188,0.23235,0.290415,0.353147,0.112422,0.170886,0.267687,0.315656,0.284866,0.0887542,0.267811,0.338547,0.147872,0.189388,0.293546,0.210125,0.292967,0.218414,0.0509944,0.0871471,0.0689852,0.0602698,0.341188,0.259328,0.437467,0.201057,0.15696,0.129351,0.141936,0.0786166,0.276997,0.205513,0.282389,0.251421,0.000807732,0.330223,0.387837,0.233244,0.207281,0.327401,0.195748,0.27845,0.161712,0.237871,0.239139,0.095257,0.328852,0.332769,0.262022,0.04166,0.266687,0.184534,0.248707,0.31749,0.15156,0.287598,0.313858,0.223773,0.25788,0.181895,0.253768,0.30702,0.202977,0.170837,0.327002,0.28543,0.222656,0.228479,0.127111,0.000269465,0.390754,0.355805,0.279739,0.108118,0.259901,0.139723,0.0708274,0.0710478,0.196248,0.102645,0.0539258,0.0709978,0.401939,0.332746,0.271338,0.242121,0.298673,0.244395,0.106889,0.128632,0.0845989,0.159153,0.0842401,0.13698,0.0874421,0.100355,0.167854,0.142846,0.0583767,0.088258,0.117657,0.0486914,0.175784,0.262778,0.373453,0.362662,0.433518,0.184359,0.334474,0.325785,0.257476,0.291176,0.376537,0.322827,0.229571,0.359036,0.335984,0.171704,0.208256,0.265058,0.256405,0.362898,0.302133,0.40806,0.151361,0.0433477,0.286696,0.150674,0.251128,0.246177,0.35674,0.35852,0.318525,0.213257,0.287217,0.122782,0.410951,0.289049,0.266974,0.125746,0.112897,0.398354,0.222091,0.205977,0.34423,0.0936726,0.343425,0.132374,0.285122,0.22741,0.203996,0.276721,0.321965,0.264707,0.450113
}}
}}

Revision as of 12:01, 5 September 2012


Full id: C2586_Alveolar_acute_Renal_Mesenchymal_Bronchial_Trabecular_Corneal



Phase1 CAGE Peaks

Hg19::chr1:43824577..43824636,+p2@CDC20
Hg19::chr1:43824639..43824659,+p1@CDC20
Hg19::chr1:43824669..43824680,+p3@CDC20
Hg19::chr9:89626496..89626506,+p1@CDC20P1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005819spindle0.0375988370513273
GO:0007067mitosis0.0375988370513273
GO:0000087M phase of mitotic cell cycle0.0375988370513273
GO:0051301cell division0.0375988370513273
GO:0006511ubiquitin-dependent protein catabolic process0.0375988370513273
GO:0043632modification-dependent macromolecule catabolic process0.0375988370513273
GO:0019941modification-dependent protein catabolic process0.0375988370513273
GO:0051603proteolysis involved in cellular protein catabolic process0.0375988370513273
GO:0044257cellular protein catabolic process0.0375988370513273
GO:0000279M phase0.0375988370513273
GO:0000278mitotic cell cycle0.0375988370513273
GO:0030163protein catabolic process0.0375988370513273
GO:0022403cell cycle phase0.0375988370513273
GO:0043285biopolymer catabolic process0.0427774430153552
GO:0015630microtubule cytoskeleton0.0427774430153552
GO:0044265cellular macromolecule catabolic process0.0427774430153552
GO:0006512ubiquitin cycle0.0427774430153552
GO:0022402cell cycle process0.0435730353789808
GO:0009057macromolecule catabolic process0.0435730353789808



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
animal cell9.69e-24679
eukaryotic cell9.69e-24679
epithelial cell1.53e-23254
embryonic cell3.70e-17248
native cell2.89e-12722
non-terminally differentiated cell1.52e-10180
squamous epithelial cell1.31e-0962
mesodermal cell5.13e-08119
somatic cell2.21e-07591
lining cell9.17e-0757
barrier cell9.17e-0757
Uber Anatomy
Ontology termp-valuen
mesenchyme1.45e-07238
entire embryonic mesenchyme1.45e-07238
simple squamous epithelium5.53e-0722
segment of respiratory tract6.93e-0746
Disease
Ontology termp-valuen
cancer1.58e-31235
disease of cellular proliferation3.14e-30239
organ system cancer7.05e-16137
hematologic cancer1.01e-1451
immune system cancer1.01e-1451
cell type cancer1.64e-14143
leukemia2.45e-1239
carcinoma1.59e-11106
myeloid leukemia1.34e-0931


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672315.13817298241780.0004682184421431190.00430232851301999
CHD2#110637.758017125587640.003351522464536340.017300793528752
E2F4#187439.501045236463330.001850751034728270.0109296345669203
EP300#203335.08045629466740.01144298405398240.0418993027246035
ETS1#211337.296570691651750.00400857377511390.0192068374775942
FOS#235336.74846648167080.005032452776317940.0234709210693462
GABPB1#255335.300762877136630.01012678824234270.037864515152586
HDAC2#3066310.06171517746970.00156372754474740.00992489462448336
IRF1#365935.727872815172930.008097114790333330.0320117565048121
IRF3#3661335.23646415861723.79279212646878e-050.000720078925461322
MAX#414934.839416631755340.01315737137836840.0466301099251896
MXI1#460137.471178721569470.003741314738550960.018635912146684
NFYA#4800313.81918552487290.0006132411806734510.00508828916090844
NFYB#4801312.56984494015230.000811456397697350.00619002956096075
PAX5#507935.002174148383370.01196533174786410.0435038218421297
POU2F2#545236.829593043306890.004860473775203740.0227643849772861
SP2#6668319.61514787038350.0002171004269245340.00248642959618065
TAF7#687938.574802053692940.00250055433515240.0140360848225831
ZBTB33#10009323.74854377248590.0001229451908818380.00165574117221255



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.