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Coexpression cluster:C2817

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Full id: C2817_Natural_CD8_CD4_CD34_Basophils_thymus_CD14



Phase1 CAGE Peaks

Hg19::chr5:162932997..162933017,+p@chr5:162932997..162933017
+
Hg19::chr5:43019699..43019711,-p@chr5:43019699..43019711
-
Hg19::chr5:43019717..43019732,-p@chr5:43019717..43019732
-
Hg19::chr5:43041092..43041124,+p@chr5:43041092..43041124
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell2.64e-56168
angioblastic mesenchymal cell2.64e-56168
hematopoietic cell3.06e-54177
leukocyte5.56e-54136
hematopoietic oligopotent progenitor cell5.64e-51161
hematopoietic multipotent progenitor cell5.64e-51161
hematopoietic lineage restricted progenitor cell3.46e-50120
nongranular leukocyte8.22e-49115
nucleate cell2.66e-3155
lymphoid lineage restricted progenitor cell5.17e-3152
lymphocyte4.77e-3053
common lymphoid progenitor4.77e-3053
myeloid cell1.81e-21108
common myeloid progenitor1.81e-21108
myeloid leukocyte4.87e-2072
classical monocyte1.37e-1942
CD14-positive, CD16-negative classical monocyte1.37e-1942
myeloid lineage restricted progenitor cell2.10e-1966
T cell2.29e-1825
pro-T cell2.29e-1825
mature alpha-beta T cell4.03e-1818
alpha-beta T cell4.03e-1818
immature T cell4.03e-1818
mature T cell4.03e-1818
immature alpha-beta T cell4.03e-1818
granulocyte monocyte progenitor cell9.27e-1867
monopoietic cell8.97e-1759
monocyte8.97e-1759
monoblast8.97e-1759
promonocyte8.97e-1759
macrophage dendritic cell progenitor9.25e-1761
defensive cell2.48e-1648
phagocyte2.48e-1648
CD8-positive, alpha-beta T cell4.45e-1211
lymphocyte of B lineage3.24e-1124
pro-B cell3.24e-1124
B cell8.14e-1114
mesenchymal cell1.08e-09354
connective tissue cell7.55e-09361
intermediate monocyte5.45e-089
CD14-positive, CD16-positive monocyte5.45e-089
motile cell1.28e-07386
CD4-positive, alpha-beta T cell5.86e-076
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.23e-2798
blood island2.23e-2798
hemolymphoid system1.17e-25108
immune system2.35e-1893
bone marrow1.06e-1576
bone element5.22e-1482
skeletal element2.54e-1190
blood2.93e-0915
haemolymphatic fluid2.93e-0915
organism substance2.93e-0915
skeletal system1.09e-08100
connective tissue2.68e-08371
Disease
Ontology termp-valuen
hematologic cancer9.23e-0751
immune system cancer9.23e-0751


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.11.65296
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.12.02743
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.11.92746
MA0040.11.12314
MA0041.11.73823
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.14.0617
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.12.05499
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.918944
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.20.00910927
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GTF2F1#296239.554745657568240.001820362319304780.0109024441028714
SMARCB1#6598418.25271578115749.00423392720929e-060.000242057448423117
SMARCC2#6601370.61653082017324.74678670742709e-060.000147281538008609
SUZ12#23512225.05789045553150.002325256716520610.013186766193348
TAF1#687243.343046285745290.008005664898701650.032309437991943
TBP#690843.706770687096390.005296377814784350.0244885958295671



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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