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Coexpression cluster:C2940

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Full id: C2940_renal_hairy_Mesenchymal_leiomyoblastoma_small_Hep2_Wilms



Phase1 CAGE Peaks

Hg19::chr9:139744155..139744222,+p2@PHPT1
Hg19::chr9:139744237..139744257,+p8@PHPT1
Hg19::chr9:139744264..139744275,+p10@PHPT1
Hg19::chr9:139744298..139744325,+p5@PHPT1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
fibroblast1.22e-1076
non-terminally differentiated cell1.83e-10106
embryonic cell1.01e-09250
contractile cell2.70e-0959
smooth muscle cell1.00e-0843
smooth muscle myoblast1.00e-0843
muscle precursor cell1.35e-0858
myoblast1.35e-0858
multi-potent skeletal muscle stem cell1.35e-0858
muscle cell6.23e-0855
mesodermal cell2.14e-07121
Uber Anatomy
Ontology termp-valuen
multi-tissue structure3.07e-22342
anatomical cluster2.08e-15373
mesenchyme3.32e-15160
entire embryonic mesenchyme3.32e-15160
organism subdivision7.83e-14264
epithelium2.28e-11306
trunk2.33e-11199
multi-cellular organism3.14e-11656
trunk mesenchyme3.90e-11122
multilaminar epithelium4.39e-1183
cell layer6.58e-11309
epithelial vesicle1.67e-1078
dense mesenchyme tissue6.16e-1073
somite1.45e-0971
presomitic mesoderm1.45e-0971
presumptive segmental plate1.45e-0971
dermomyotome1.45e-0971
trunk paraxial mesoderm1.45e-0971
paraxial mesoderm1.53e-0972
presumptive paraxial mesoderm1.53e-0972
anatomical system1.71e-09624
anatomical group1.99e-09625
skeletal muscle tissue6.46e-0962
striated muscle tissue6.46e-0962
myotome6.46e-0962
muscle tissue1.06e-0864
musculature1.06e-0864
musculature of body1.06e-0864
surface structure2.78e-0899
endoderm-derived structure4.35e-08160
endoderm4.35e-08160
presumptive endoderm4.35e-08160
larynx1.38e-079
primordium1.95e-07160
anatomical conduit3.51e-07240
organ system subdivision7.88e-07223


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602434.54710280373837.01262157705428e-073.15685855554298e-05
CCNT2#90534.752151182721970.01386206996689490.0487520448973778
E2F1#186944.907389214879320.001724022357361790.0106876696729689
E2F6#187645.017155731697390.00157802193473060.00999800005103913
EBF1#187948.9064668465690.00015887907472010.00200207187315306
EGR1#195844.988179094810140.001615011500076050.0101694312104451
ETS1#211349.728760922202340.0001115955317418140.00154882734080841
GABPB1#255347.067683836182170.0004006876864423170.00391060847438082
HEY1#2346244.040111043105710.00375304636917980.0186720850681579
NFKB1#479045.488063424193840.001102199566301980.0076962372471092
SIN3A#2594245.408884726815140.001168172384885160.00798551876587386
TAF1#687243.343046285745290.008005664898701650.0323531956953721
TAF7#6879411.43306940492395.85061525419808e-050.000972671770985663
TBP#690843.706770687096390.005296377814784350.0245189894768733
THAP1#55145431.36914460285131.03171810326891e-064.3291123739374e-05
YY1#752844.911170749853860.00171871838055440.0107139327293017
ZBTB7A#5134147.35190930787590.000342223540015990.00347375685642239
ZNF263#1012748.221841637010680.0002187871180958320.0025021800073161



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.