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Coexpression cluster:C3006

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Full id: C3006_acute_neuroblastoma_kidney_occipital_parietal_postcentral_paracentral



Phase1 CAGE Peaks

  Short description
Hg19::chr10:23983671..23983704,+ p9@KIAA1217
Hg19::chr10:23983752..23983767,+ p19@KIAA1217
Hg19::chr10:23983950..23983961,+ p22@KIAA1217


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube8.34e-7556
neural rod8.34e-7556
future spinal cord8.34e-7556
neural keel8.34e-7556
regional part of nervous system1.63e-6853
regional part of brain1.63e-6853
regional part of forebrain3.47e-6541
forebrain3.47e-6541
anterior neural tube3.47e-6541
future forebrain3.47e-6541
brain grey matter4.62e-6334
gray matter4.62e-6334
telencephalon1.14e-6234
cerebral hemisphere5.15e-5932
regional part of telencephalon2.08e-5832
nervous system2.15e-5889
central nervous system9.36e-5881
brain6.45e-5668
future brain6.45e-5668
adult organism8.09e-56114
neurectoderm2.68e-5486
neural plate2.68e-5282
presumptive neural plate2.68e-5282
regional part of cerebral cortex1.71e-5022
neocortex4.74e-4620
pre-chordal neural plate4.97e-4661
cerebral cortex7.21e-4425
pallium7.21e-4425
ecto-epithelium1.50e-38104
structure with developmental contribution from neural crest3.25e-32132
ectoderm-derived structure8.60e-31171
ectoderm8.60e-31171
presumptive ectoderm8.60e-31171
organ system subdivision2.28e-26223
neural nucleus2.05e-209
nucleus of brain2.05e-209
basal ganglion2.60e-209
nuclear complex of neuraxis2.60e-209
aggregate regional part of brain2.60e-209
collection of basal ganglia2.60e-209
cerebral subcortex2.60e-209
gyrus3.89e-166
telencephalic nucleus6.99e-167
tube4.18e-15192
anatomical cluster1.88e-14373
parietal lobe1.64e-135
occipital lobe2.27e-135
temporal lobe5.02e-136
limbic system9.56e-135
anatomical conduit1.37e-12240
posterior neural tube9.60e-1215
chordal neural plate9.60e-1215
organ part5.04e-11218
brainstem1.17e-106
corpus striatum5.25e-104
striatum5.25e-104
ventral part of telencephalon5.25e-104
future corpus striatum5.25e-104
multi-tissue structure2.45e-09342
frontal cortex6.55e-093
pons1.30e-083
epithelium2.51e-08306
cell layer3.95e-08309
spinal cord7.61e-083
dorsal region element7.61e-083
dorsum7.61e-083
caudate-putamen9.88e-083
dorsal striatum9.88e-083
male genital duct1.31e-073
internal male genitalia1.31e-073
embryo1.39e-07592
segmental subdivision of hindbrain6.11e-0712
hindbrain6.11e-0712
presumptive hindbrain6.11e-0712
germ layer7.07e-07560
germ layer / neural crest7.07e-07560
embryonic tissue7.07e-07560
presumptive structure7.07e-07560
germ layer / neural crest derived structure7.07e-07560
epiblast (generic)7.07e-07560


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.12.61424
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.18.0808
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.21.15986
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.21.54885
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SUZ12#23512350.11578091106297.93834897779404e-060.00022102725377015
ZNF263#1012738.221841637010680.001799043925565870.0108884068464403



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.