Coexpression cluster:C3053

Full id: C3053_Eosinophils_Neutrophils_CD14_granulocyte_immature_CD8_Basophils

Phase1 CAGE Peaks

Hg19::chr10:88281494..88281570,-	p1@WAPAL
Hg19::chr16:75498553..75498621,-	p1@TMEM170A
Hg19::chr5:139781445..139781487,+	p2@ANKHD1-EIF4EBP3 p2@ANKHD1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	3.92e-56	172
angioblastic mesenchymal cell	3.92e-56	172
hematopoietic oligopotent progenitor cell	1.48e-52	165
hematopoietic multipotent progenitor cell	1.48e-52	165
leukocyte	2.94e-51	140
hematopoietic cell	3.90e-50	182
hematopoietic lineage restricted progenitor cell	4.91e-42	124
nongranular leukocyte	4.58e-41	119
myeloid cell	9.88e-38	112
common myeloid progenitor	9.88e-38	112
myeloid leukocyte	1.49e-33	76
granulocyte monocyte progenitor cell	3.66e-30	71
myeloid lineage restricted progenitor cell	2.61e-28	70
macrophage dendritic cell progenitor	7.63e-28	65
monopoietic cell	1.12e-26	63
monocyte	1.12e-26	63
monoblast	1.12e-26	63
promonocyte	1.12e-26	63
classical monocyte	9.02e-25	45
CD14-positive, CD16-negative classical monocyte	4.80e-24	42
lymphocyte	9.04e-13	53
common lymphoid progenitor	9.04e-13	53
lymphoid lineage restricted progenitor cell	2.12e-12	52

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.81e-31	102
blood island	1.81e-31	102
hemolymphoid system	2.91e-28	112
bone element	4.45e-23	86
bone marrow	4.94e-23	80
immune system	1.90e-20	115
skeletal element	1.04e-15	101
skeletal system	1.04e-15	101
blood	7.56e-07	15
haemolymphatic fluid	7.56e-07	15
organism substance	7.56e-07	15

Disease

Ontology term	p-value	n
hematologic cancer	8.01e-07	51
immune system cancer	8.01e-07	51

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BRCA1#672	2	13.4561537621492	0.00711980771608456	0.0296084095747454
CHD2#1106	3	10.3440228341169	0.000903370110274688	0.00658250686855356
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0323494233665374
E2F4#1874	3	12.6680603152844	0.000491798700629898	0.00435242475172324
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0459967665161957
ETS1#2113	3	9.72876092220234	0.00108584009258484	0.00759724348023499
FOS#2353	3	8.9979553088944	0.00137249927241713	0.0089466016422402
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.0108275752508615
IRF3#3661	2	31.3213014743264	0.00133951467332011	0.00887449714329355
MAX#4149	3	6.45255550900712	0.00372191383426551	0.0185676120820088
MXI1#4601	3	9.9615716287593	0.00101147054125902	0.00717983904428403
MYC#4609	3	5.2222818716094	0.00702084375574015	0.029317096517762
NFYA#4800	3	18.4255806998305	0.000159813550781416	0.00198983874941111
NFYB#4801	3	16.7597932535365	0.000212364992329618	0.0024491152201759
NRF1#4899	3	12.2102794477109	0.000549217240102001	0.00469315163958541
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0172231649320005
PBX3#5090	2	14.6096751244961	0.00605612247321789	0.0268063307895912
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0245395217446027
SP2#6668	2	17.4356869958964	0.00427356848176974	0.0203069847885504
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0189474199352463
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0327848408182333
ZNF143#7702	3	13.5008765522279	0.000406280496299717	0.00387573335340209
ZNF263#10127	3	8.22184163701068	0.00179904392556587	0.0108928255865369

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.