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Revision as of 05:31, 21 May 2012

Full id: C3063_immature_Neutrophils_Eosinophils_CD14_Monocytederived_Whole_CD14CD16

Phase1 CAGE Peaks

  Short description
Hg19::chr10:97457405..97457451,+ p@chr10:97457405..97457451
Hg19::chr11:85956323..85956338,+ p7@EED
Hg19::chr11:85956340..85956357,+ p9@EED

Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset

No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset

No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.31e-56172
angioblastic mesenchymal cell1.31e-56172
hematopoietic oligopotent progenitor cell1.19e-52165
hematopoietic multipotent progenitor cell1.19e-52165
hematopoietic cell2.03e-52182
nongranular leukocyte3.73e-44119
hematopoietic lineage restricted progenitor cell6.02e-43124
myeloid cell4.37e-41112
common myeloid progenitor4.37e-41112
myeloid leukocyte8.06e-3876
macrophage dendritic cell progenitor3.97e-3565
monopoietic cell1.65e-3363
myeloid lineage restricted progenitor cell1.45e-3270
granulocyte monocyte progenitor cell1.88e-3271
CD14-positive, CD16-negative classical monocyte1.31e-2942
classical monocyte6.58e-2945
common lymphoid progenitor2.10e-1053
lymphoid lineage restricted progenitor cell5.78e-1052
lymphocyte of B lineage7.49e-1024
pro-B cell7.49e-1024
mesenchymal cell2.42e-09358
dendritic cell1.94e-0810
connective tissue cell3.39e-08365
intermediate monocyte6.69e-089
CD14-positive, CD16-positive monocyte6.69e-089
motile cell1.62e-07390
conventional dendritic cell3.80e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.92e-37102
blood island2.92e-37102
hemolymphoid system9.47e-33112
bone marrow4.23e-2880
bone element1.14e-2586
skeletal element6.26e-20101
skeletal system6.26e-20101
immune system3.76e-18115
connective tissue3.07e-08375
haemolymphatic fluid5.63e-0815
organism substance5.63e-0815

Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs

Jaspar motifs

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset


No analysis results for this cluster

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.

link to data source

This analysis result is provided for C0 - C305 clusters.