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Coexpression cluster:C3063

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Full id: C3063_immature_Neutrophils_Eosinophils_CD14_Monocytederived_Whole_CD14CD16



Phase1 CAGE Peaks

  Short description
Hg19::chr10:97457405..97457451,+ p@chr10:97457405..97457451
+
Hg19::chr11:85956323..85956338,+ p7@EED
Hg19::chr11:85956340..85956357,+ p9@EED


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.31e-56172
angioblastic mesenchymal cell1.31e-56172
leukocyte1.53e-54140
hematopoietic oligopotent progenitor cell1.19e-52165
hematopoietic multipotent progenitor cell1.19e-52165
hematopoietic cell2.03e-52182
nongranular leukocyte3.73e-44119
hematopoietic lineage restricted progenitor cell6.02e-43124
myeloid cell4.37e-41112
common myeloid progenitor4.37e-41112
myeloid leukocyte8.06e-3876
macrophage dendritic cell progenitor3.97e-3565
monopoietic cell1.65e-3363
monocyte1.65e-3363
monoblast1.65e-3363
promonocyte1.65e-3363
myeloid lineage restricted progenitor cell1.45e-3270
granulocyte monocyte progenitor cell1.88e-3271
CD14-positive, CD16-negative classical monocyte1.31e-2942
classical monocyte6.58e-2945
lymphocyte2.10e-1053
common lymphoid progenitor2.10e-1053
lymphoid lineage restricted progenitor cell5.78e-1052
lymphocyte of B lineage7.49e-1024
pro-B cell7.49e-1024
mesenchymal cell2.42e-09358
dendritic cell1.94e-0810
connective tissue cell3.39e-08365
intermediate monocyte6.69e-089
CD14-positive, CD16-positive monocyte6.69e-089
motile cell1.62e-07390
granulocyte2.63e-078
conventional dendritic cell3.80e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.92e-37102
blood island2.92e-37102
hemolymphoid system9.47e-33112
bone marrow4.23e-2880
bone element1.14e-2586
skeletal element6.26e-20101
skeletal system6.26e-20101
immune system3.76e-18115
connective tissue3.07e-08375
blood5.63e-0815
haemolymphatic fluid5.63e-0815
organism substance5.63e-0815


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467214.97544968400580.005768294540793880.0259435387600005
BCLAF1#9774214.43509840674790.006201147435546130.0273728502544802
MAX#414936.452555509007120.003721913834265510.0185693860859339
NFKB1#479035.488063424193840.006049381815655430.0268550279454747
SIX5#147912211.3911435703060.009873820081429030.0370579615296067
SMARCB1#6598212.16847718743830.008675002221921740.0329697437065242
SPI1#668838.204323508522730.001810593189410520.0108794972733931
TFAP2A#7020211.01242291536330.01054990655215560.0389914958737555



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.