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Coexpression cluster:C3138

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Full id: C3138_parietal_merkel_thyroid_occipital_temporal_transitionalcell_pharyngeal



Phase1 CAGE Peaks

Hg19::chr11:30608248..30608277,-p3@MPPED2
Hg19::chr11:30608294..30608317,-p7@MPPED2
Hg19::chr11:30608413..30608423,-p17@MPPED2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
neural cell5.69e-1225
neuronal stem cell4.18e-118
neuron1.23e-076
neuroblast1.23e-076
electrically signaling cell1.23e-076
Uber Anatomy
Ontology termp-valuen
central nervous system4.82e-5381
neural tube1.21e-4856
neural rod1.21e-4856
future spinal cord1.21e-4856
neural keel1.21e-4856
nervous system2.53e-4889
regional part of nervous system1.04e-4653
regional part of brain1.04e-4653
adult organism1.78e-40114
regional part of forebrain3.83e-4041
forebrain3.83e-4041
anterior neural tube3.83e-4041
future forebrain3.83e-4041
brain3.76e-3968
future brain3.76e-3968
cerebral hemisphere9.41e-3632
brain grey matter1.25e-3534
gray matter1.25e-3534
telencephalon1.50e-3534
neural plate4.26e-3482
presumptive neural plate4.26e-3482
regional part of telencephalon4.46e-3332
neurectoderm7.23e-3286
cerebral cortex8.95e-3125
pallium8.95e-3125
ectoderm-derived structure1.55e-29171
ectoderm1.55e-29171
presumptive ectoderm1.55e-29171
ecto-epithelium2.24e-28104
pre-chordal neural plate3.12e-2761
neocortex3.91e-2720
regional part of cerebral cortex8.59e-2722
organ system subdivision1.48e-24223
structure with developmental contribution from neural crest1.11e-21132
anatomical cluster3.89e-16373
anatomical conduit7.25e-11240
gyrus5.50e-106
parietal lobe6.61e-105
posterior neural tube8.42e-1015
chordal neural plate8.42e-1015
tube1.24e-09192
multi-tissue structure1.63e-09342
organ8.67e-09503
temporal lobe1.24e-086
multi-cellular organism2.39e-08656
embryo2.68e-08592
corpus striatum3.72e-084
striatum3.72e-084
ventral part of telencephalon3.72e-084
future corpus striatum3.72e-084
organ part4.74e-08218
segmental subdivision of hindbrain5.24e-0812
hindbrain5.24e-0812
presumptive hindbrain5.24e-0812
anatomical system5.41e-08624
anatomical group6.13e-08625
developing anatomical structure2.06e-07581
segmental subdivision of nervous system2.81e-0713
germ layer4.15e-07560
germ layer / neural crest4.15e-07560
embryonic tissue4.15e-07560
presumptive structure4.15e-07560
germ layer / neural crest derived structure4.15e-07560
epiblast (generic)4.15e-07560
brainstem4.27e-076
basal ganglion4.32e-079
nuclear complex of neuraxis4.32e-079
aggregate regional part of brain4.32e-079
collection of basal ganglia4.32e-079
cerebral subcortex4.32e-079
embryonic structure6.74e-07564
neural nucleus8.64e-079
nucleus of brain8.64e-079
epithelium8.90e-07306
caudate-putamen9.62e-073
dorsal striatum9.62e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
RAD21#5885310.35503389545630.0009004912073565420.00661925684157586



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.