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Coexpression cluster:C3497

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Full id: C3497_skeletal_CD14_Dendritic_Monocytederived_Basophils_Macrophage_immature



Phase1 CAGE Peaks

Hg19::chr15:51058130..51058152,-p2@SPPL2A
Hg19::chr8:74888516..74888527,+p3@TMEM70
Hg19::chr8:74888542..74888594,+p2@TMEM70


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004190aspartic-type endopeptidase activity0.0449814078230606



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
granulocyte monocyte progenitor cell8.14e-3271
myeloid leukocyte1.75e-3176
macrophage dendritic cell progenitor3.46e-2965
myeloid lineage restricted progenitor cell4.21e-2970
monopoietic cell5.78e-2863
monocyte5.78e-2863
monoblast5.78e-2863
promonocyte5.78e-2863
CD14-positive, CD16-negative classical monocyte3.77e-2642
classical monocyte6.15e-2345
leukocyte8.93e-23140
hematopoietic lineage restricted progenitor cell1.46e-20124
myeloid cell1.74e-19112
common myeloid progenitor1.74e-19112
nongranular leukocyte7.00e-19119
mesenchymal cell5.56e-18358
hematopoietic stem cell5.41e-17172
angioblastic mesenchymal cell5.41e-17172
connective tissue cell6.76e-17365
hematopoietic cell9.73e-16182
hematopoietic oligopotent progenitor cell2.51e-15165
hematopoietic multipotent progenitor cell2.51e-15165
motile cell4.25e-14390
multi fate stem cell3.11e-12430
somatic stem cell1.13e-10436
stem cell7.47e-10444
Uber Anatomy
Ontology termp-valuen
bone marrow3.35e-2880
bone element4.27e-2786
hematopoietic system2.01e-26102
blood island2.01e-26102
hemolymphoid system1.79e-24112
skeletal element1.01e-21101
skeletal system1.01e-21101
immune system6.76e-20115
connective tissue1.57e-16375
adult organism1.77e-15115
musculoskeletal system5.36e-12167
lateral plate mesoderm1.35e-07216
tissue7.09e-07787


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.