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Difference between revisions of "Coexpression cluster:C3503"

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|tf_chipseq_enrich=BCL3#602;3:34.5471028037383:2.42397750207122e-05:0.000526753612856463!BCLAF1#9774;3:21.6526476101218:9.8473954032885e-05:0.00139092795310258!CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0189679620655754!CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129416497077654!CTCF#10664;3:5.36025637307503:0.006492509252767:0.027900718999701!CTCFL#140690;3:19.7464743589744:0.000129837200555116:0.00171472779321899!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0324563596811994!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0319879700646361!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0461238077439998!ELK4#2005;3:16.235681658468:0.000233604395574599:0.00255470256224246!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167231350199273!ETS1#2113;3:9.72876092220234:0.00108584009258484:0.00760998882227001!GABPB1#2553;3:7.06768383618217:0.00283221282541742:0.0153866768244783!GATA1#2623;3:13.5603081438004:0.000400961596378263:0.00387453998558007!GTF2B#2959;3:31.9438299343242:3.06634405746243e-05:0.000627072463319599!GTF2F1#2962;3:12.7396608767577:0.000483552504743859:0.00433342543701252!HDAC2#3066;3:13.4156202366263:0.000414076139985721:0.00390656711688967!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.0108540485399834!JUND#3727;3:6.99466394187103:0.00292184504273499:0.0156481500650325!NR3C1#2908;3:14.973023331173:0.000297833119467548:0.0030840167721665!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00470431389641704!PAX5#5079;3:6.66956553117783:0.00337029099967726:0.017265405489542!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.0066309244310167!REST#5978;3:9.65002871612802:0.00111263624711459:0.00766406918694108!RXRA#6256;2:13.3830780927555:0.00719643442946573:0.0298225702475586!SMARCB1#6598;3:18.2527157811574:0.00016439776067989:0.00202781832144172!SMC3#9126;3:15.0449328449328:0.000293582542037187:0.00308558590196455!STAT1#6772;3:20.7065874971992:0.000112599244104667:0.00154652189045861!TCF7L2#6934;3:10.7701765631373:0.000800318129839838:0.00612699202186944!TFAP2A#7020;3:16.518634373045:0.000221803388076634:0.00247806205042101!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00614322829054968!THAP1#55145;3:31.3691446028513:3.23800758564397e-05:0.000645863778145666!TRIM28#10155;3:18.5905250452625:0.000155596929725528:0.00196759749892292!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0189962214757745!USF2#7392;3:12.9921973850696:0.000455897939342781:0.0042113501580595!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0328667295870531!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0139881431730462!ZEB1#6935;3:16.8884320175439:0.000207548691732758:0.00242408608989907!ZNF143#7702;3:13.5008765522279:0.000406280496299717:0.00388424832964538
 
|tf_chipseq_enrich=BCL3#602;3:34.5471028037383:2.42397750207122e-05:0.000526753612856463!BCLAF1#9774;3:21.6526476101218:9.8473954032885e-05:0.00139092795310258!CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0189679620655754!CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129416497077654!CTCF#10664;3:5.36025637307503:0.006492509252767:0.027900718999701!CTCFL#140690;3:19.7464743589744:0.000129837200555116:0.00171472779321899!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0324563596811994!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0319879700646361!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0461238077439998!ELK4#2005;3:16.235681658468:0.000233604395574599:0.00255470256224246!EP300#2033;3:6.7739417262232:0.00321688050010379:0.0167231350199273!ETS1#2113;3:9.72876092220234:0.00108584009258484:0.00760998882227001!GABPB1#2553;3:7.06768383618217:0.00283221282541742:0.0153866768244783!GATA1#2623;3:13.5603081438004:0.000400961596378263:0.00387453998558007!GTF2B#2959;3:31.9438299343242:3.06634405746243e-05:0.000627072463319599!GTF2F1#2962;3:12.7396608767577:0.000483552504743859:0.00433342543701252!HDAC2#3066;3:13.4156202366263:0.000414076139985721:0.00390656711688967!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.0108540485399834!JUND#3727;3:6.99466394187103:0.00292184504273499:0.0156481500650325!NR3C1#2908;3:14.973023331173:0.000297833119467548:0.0030840167721665!NRF1#4899;3:12.2102794477109:0.000549217240102001:0.00470431389641704!PAX5#5079;3:6.66956553117783:0.00337029099967726:0.017265405489542!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.0066309244310167!REST#5978;3:9.65002871612802:0.00111263624711459:0.00766406918694108!RXRA#6256;2:13.3830780927555:0.00719643442946573:0.0298225702475586!SMARCB1#6598;3:18.2527157811574:0.00016439776067989:0.00202781832144172!SMC3#9126;3:15.0449328449328:0.000293582542037187:0.00308558590196455!STAT1#6772;3:20.7065874971992:0.000112599244104667:0.00154652189045861!TCF7L2#6934;3:10.7701765631373:0.000800318129839838:0.00612699202186944!TFAP2A#7020;3:16.518634373045:0.000221803388076634:0.00247806205042101!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00614322829054968!THAP1#55145;3:31.3691446028513:3.23800758564397e-05:0.000645863778145666!TRIM28#10155;3:18.5905250452625:0.000155596929725528:0.00196759749892292!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0189962214757745!USF2#7392;3:12.9921973850696:0.000455897939342781:0.0042113501580595!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0328667295870531!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0139881431730462!ZEB1#6935;3:16.8884320175439:0.000207548691732758:0.00242408608989907!ZNF143#7702;3:13.5008765522279:0.000406280496299717:0.00388424832964538
 
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 +
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}}
 
}}

Revision as of 07:10, 26 November 2012


Full id: C3503_osteoclastoma_acute_small_hepatoblastoma_stomach_sacrococcigeal_heart



Phase1 CAGE Peaks

  Short description
Hg19::chr15:63340604..63340622,+ p7@TPM1
Hg19::chr15:63340647..63340728,+ p2@TPM1
Hg19::chr15:63340734..63340769,+ p4@TPM1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism6.54e-29114
organ system subdivision7.04e-22223
anatomical cluster8.09e-22373
multi-tissue structure1.50e-16342
anatomical conduit1.43e-15240
multi-cellular organism1.96e-15656
neural tube3.82e-1356
neural rod3.82e-1356
future spinal cord3.82e-1356
neural keel3.82e-1356
anatomical system1.67e-12624
cell layer2.02e-12309
epithelium2.27e-12306
tube2.50e-12192
anatomical group3.45e-12625
central nervous system3.80e-1281
regional part of nervous system4.30e-1253
regional part of brain4.30e-1253
brain6.36e-1268
future brain6.36e-1268
nervous system1.42e-1189
regional part of forebrain1.29e-1041
forebrain1.29e-1041
anterior neural tube1.29e-1041
future forebrain1.29e-1041
embryo4.62e-10592
brain grey matter7.60e-1034
gray matter7.60e-1034
neural plate1.08e-0982
presumptive neural plate1.08e-0982
subdivision of digestive tract1.39e-09118
cerebral hemisphere1.66e-0932
telencephalon2.71e-0934
regional part of telencephalon3.52e-0932
regional part of cerebral cortex3.87e-0922
germ layer1.43e-08560
germ layer / neural crest1.43e-08560
embryonic tissue1.43e-08560
presumptive structure1.43e-08560
germ layer / neural crest derived structure1.43e-08560
epiblast (generic)1.43e-08560
embryonic structure1.72e-08564
digestive system2.36e-08145
digestive tract2.36e-08145
primitive gut2.36e-08145
developing anatomical structure2.41e-08581
neocortex3.14e-0820
organ3.50e-08503
structure with developmental contribution from neural crest4.96e-08132
cerebral cortex6.45e-0825
pallium6.45e-0825
ecto-epithelium7.25e-08104
neurectoderm7.91e-0886
organ part1.35e-07218
endoderm-derived structure3.41e-07160
endoderm3.41e-07160
presumptive endoderm3.41e-07160


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602334.54710280373832.42397750207122e-050.000526753612856463
BCLAF1#9774321.65264761012189.8473954032885e-050.00139092795310258
CCNT2#90536.336201576962630.003930750035764890.0189679620655754
CTBP2#1488362.71700033932814.049570681927e-060.000129416497077654
CTCF#1066435.360256373075030.0064925092527670.027900718999701
CTCFL#140690319.74647435897440.0001298372005551160.00171472779321899
E2F1#186934.907389214879320.008460985347239390.0324563596811994
EGR1#195834.988179094810140.008056488137383440.0319879700646361
ELF1#199734.258097958807540.01295179875054610.0461238077439998
ELK4#2005316.2356816584680.0002336043955745990.00255470256224246
EP300#203336.77394172622320.003216880500103790.0167231350199273
ETS1#211339.728760922202340.001085840092584840.00760998882227001
GABPB1#255337.067683836182170.002832212825417420.0153866768244783
GATA1#2623313.56030814380040.0004009615963782630.00387453998558007
GTF2B#2959331.94382993432423.06634405746243e-050.000627072463319599
GTF2F1#2962312.73966087675770.0004835525047438590.00433342543701252
HDAC2#3066313.41562023662630.0004140761399857210.00390656711688967
HMGN3#932438.178547723350590.001827766942164210.0108540485399834
JUND#372736.994663941871030.002921845042734990.0156481500650325
NR3C1#2908314.9730233311730.0002978331194675480.0030840167721665
NRF1#4899312.21027944771090.0005492172401020010.00470431389641704
PAX5#507936.669565531177830.003370290999677260.017265405489542
RAD21#5885310.35503389545630.0009004912073565420.0066309244310167
REST#597839.650028716128020.001112636247114590.00766406918694108
RXRA#6256213.38307809275550.007196434429465730.0298225702475586
SMARCB1#6598318.25271578115740.000164397760679890.00202781832144172
SMC3#9126315.04493284493280.0002935825420371870.00308558590196455
STAT1#6772320.70658749719920.0001125992441046670.00154652189045861
TCF7L2#6934310.77017656313730.0008003181298398380.00612699202186944
TFAP2A#7020316.5186343730450.0002218033880766340.00247806205042101
TFAP2C#7022310.80922860986020.0007916746575753130.00614322829054968
THAP1#55145331.36914460285133.23800758564397e-050.000645863778145666
TRIM28#10155318.59052504526250.0001555969297255280.00196759749892292
USF1#739136.361499277207960.00388404057290560.0189962214757745
USF2#7392312.99219738506960.0004558979393427810.0042113501580595
YY1#752834.911170749853860.008441455341808260.0328667295870531
ZBTB7A#5134137.35190930787590.002516255860282270.0139881431730462
ZEB1#6935316.88843201754390.0002075486917327580.00242408608989907
ZNF143#7702313.50087655222790.0004062804962997170.00388424832964538



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.