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Coexpression cluster:C359

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Full id: C359_xeroderma_tonsil_acute_colon_lymph_trachea_bladder



Phase1 CAGE Peaks

Hg19::chr11:131056606..131056628,-p@chr11:131056606..131056628
-
Hg19::chr11:32154200..32154208,+p1@ENST00000525133
Hg19::chr11:33676379..33676397,+p@chr11:33676379..33676397
+
Hg19::chr11:57182176..57182224,-p@chr11:57182176..57182224
-
Hg19::chr11:77150035..77150044,-p@chr11:77150035..77150044
-
Hg19::chr14:106329430..106329463,-p1@uc001yrw.1
p1@uc001ysj.2
p1@uc001ysk.1
p1@uc001ysl.1
Hg19::chr14:107170409..107170434,-p1@IGHV1-69
Hg19::chr14:75802600..75802617,+p@chr14:75802600..75802617
+
Hg19::chr14:75802635..75802649,+p@chr14:75802635..75802649
+
Hg19::chr15:55611565..55611576,+p7@PIGB
Hg19::chr17:76130076..76130100,-p@chr17:76130076..76130100
-
Hg19::chr17:9955844..9955857,-p@chr17:9955844..9955857
-
Hg19::chr17:9955874..9955881,-p@chr17:9955874..9955881
-
Hg19::chr18:56203145..56203154,+p@chr18:56203145..56203154
+
Hg19::chr18:67613122..67613129,-p@chr18:67613122..67613129
-
Hg19::chr19:7766976..7766982,-p9@FCER2
Hg19::chr1:101837029..101837058,+p@chr1:101837029..101837058
+
Hg19::chr1:101914223..101914228,-p@chr1:101914223..101914228
-
Hg19::chr1:111682499..111682513,+p5@CEPT1
Hg19::chr1:111772329..111772341,+p7@CHI3L2
Hg19::chr1:111772350..111772370,+p3@CHI3L2
Hg19::chr1:111772381..111772415,+p2@CHI3L2
Hg19::chr1:111772435..111772463,+p4@CHI3L2
Hg19::chr1:152880744..152880747,+p3@IVL
Hg19::chr1:152880760..152880771,+p2@IVL
Hg19::chr22:23055620..23055631,+p1@DQ234400
Hg19::chr22:23055632..23055638,+p3@DQ234400
Hg19::chr22:26346329..26346352,+p@chr22:26346329..26346352
+
Hg19::chr4:5364767..5364769,+p@chr4:5364767..5364769
+
Hg19::chr7:55583740..55583751,-p5@VOPP1
Hg19::chr7:70241758..70241770,+p47@AUTS2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008654phospholipid biosynthetic process0.010737464781943
GO:0046467membrane lipid biosynthetic process0.010737464781943
GO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine0.010737464781943
GO:0018262isopeptide cross-linking0.010737464781943
GO:0018199peptidyl-glutamine modification0.010737464781943
GO:0004307ethanolaminephosphotransferase activity0.0111736804937354
GO:0004142diacylglycerol cholinephosphotransferase activity0.0111736804937354
GO:0006644phospholipid metabolic process0.0111736804937354
GO:0019863IgE binding0.0142568348656904
GO:0006643membrane lipid metabolic process0.0142568348656904
GO:0010224response to UV-B0.0146376878124516
GO:0008610lipid biosynthetic process0.0165118839613148
GO:0017169CDP-alcohol phosphatidyltransferase activity0.0165118839613148
GO:0018205peptidyl-lysine modification0.0172477522886803
GO:0006032chitin catabolic process0.0186546222107435
GO:0006046N-acetylglucosamine catabolic process0.0186546222107435
GO:0005789endoplasmic reticulum membrane0.0186546222107435
GO:0006043glucosamine catabolic process0.0186546222107435
GO:0046348amino sugar catabolic process0.0186546222107435
GO:0006030chitin metabolic process0.0186546222107435
GO:0004568chitinase activity0.0186546222107435
GO:0042175nuclear envelope-endoplasmic reticulum network0.0186546222107435
GO:0019865immunoglobulin binding0.0186546222107435
GO:0044432endoplasmic reticulum part0.0208492312452853
GO:0044247cellular polysaccharide catabolic process0.0208492312452853
GO:0000272polysaccharide catabolic process0.0208492312452853
GO:0016780phosphotransferase activity, for other substituted phosphate groups0.0208492312452853
GO:0001533cornified envelope0.0210604286585
GO:0018149peptide cross-linking0.0240242630131579
GO:0000030mannosyltransferase activity0.0241148894453259
GO:0006506GPI anchor biosynthetic process0.0250619670405395
GO:0030216keratinocyte differentiation0.0251141318157448
GO:0006505GPI anchor metabolic process0.0251630157626931
GO:0009411response to UV0.0253310637807865
GO:0006044N-acetylglucosamine metabolic process0.0253310637807865
GO:0046489phosphoinositide biosynthetic process0.0253310637807865
GO:0006041glucosamine metabolic process0.0253310637807865
GO:0031424keratinization0.0267667332897792
GO:0044255cellular lipid metabolic process0.0267667332897792
GO:0006040amino sugar metabolic process0.0267667332897792
GO:0005178integrin binding0.0267667332897792
GO:0046474glycerophospholipid biosynthetic process0.0293051626849468
GO:0009913epidermal cell differentiation0.0304836773360426
GO:0006497protein amino acid lipidation0.0319707530670764
GO:0042158lipoprotein biosynthetic process0.0319707530670764
GO:0048730epidermis morphogenesis0.0319707530670764
GO:0005783endoplasmic reticulum0.0320917655350622
GO:0006629lipid metabolic process0.0341520913372628
GO:0048729tissue morphogenesis0.0384680295948203
GO:0012505endomembrane system0.0384680295948203
GO:0030384phosphoinositide metabolic process0.0415056245270081
GO:0009416response to light stimulus0.0415056245270081
GO:0042157lipoprotein metabolic process0.0415056245270081
GO:0044264cellular polysaccharide metabolic process0.0415056245270081
GO:0005976polysaccharide metabolic process0.0417151002173427
GO:0030674protein binding, bridging0.0433362327013298
GO:0006650glycerophospholipid metabolic process0.0456192018890636
GO:0009314response to radiation0.0456192018890636
GO:0032403protein complex binding0.0456192018890636



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
leukocyte7.39e-35140
hematopoietic stem cell2.51e-34172
angioblastic mesenchymal cell2.51e-34172
nongranular leukocyte2.21e-31119
hematopoietic oligopotent progenitor cell4.09e-31165
hematopoietic multipotent progenitor cell4.09e-31165
hematopoietic lineage restricted progenitor cell4.58e-31124
hematopoietic cell5.42e-31182
lymphocyte5.38e-2853
common lymphoid progenitor5.38e-2853
lymphoid lineage restricted progenitor cell1.65e-2752
lymphocyte of B lineage6.11e-1724
pro-B cell6.11e-1724
T cell7.28e-1125
pro-T cell7.28e-1125
B cell1.47e-1014
myeloid cell4.48e-09112
common myeloid progenitor4.48e-09112
mature alpha-beta T cell8.52e-0918
alpha-beta T cell8.52e-0918
immature T cell8.52e-0918
mature T cell8.52e-0918
immature alpha-beta T cell8.52e-0918
granulocyte monocyte progenitor cell4.81e-0871
myeloid leukocyte1.10e-0776
myeloid lineage restricted progenitor cell1.28e-0770
macrophage dendritic cell progenitor3.13e-0765
monopoietic cell9.67e-0763
monocyte9.67e-0763
monoblast9.67e-0763
promonocyte9.67e-0763
Uber Anatomy
Ontology termp-valuen
adult organism7.41e-27115
hematopoietic system1.93e-14102
blood island1.93e-14102
hemolymphoid system6.85e-13112
blood3.38e-0815
haemolymphatic fluid3.38e-0815
organism substance3.38e-0815
Disease
Ontology termp-valuen
hematologic cancer3.18e-0751
immune system cancer3.18e-0751


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#5333576.406005991137088.40163614903359e-050.00126125985017812
BCL3#60244.457690684353330.0118271718455860.0430854930545591
EBF1#1879154.309580732210812.89067900838075e-071.46340099348656e-05
IRF4#366253.53459882044260.01245197612670210.0450723299031865
NFKB1#4790162.832548864100042.68068349868494e-050.000574293136244423
POU2F2#545292.64371343611880.004891568891958950.0228884661069579
TCF12#693882.744378039273910.006663992092590880.0283552931414992
ZEB1#693563.268728777589130.008791263817974920.0333921589280435



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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