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Coexpression cluster:C366

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Full id: C366_heart_vagina_adipose_diaphragm_left_aorta_breast



Phase1 CAGE Peaks

Hg19::chr10:15647768..15647794,-p@chr10:15647768..15647794
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Hg19::chr10:92678409..92678410,-p@chr10:92678409..92678410
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Hg19::chr11:123340107..123340127,+p@chr11:123340107..123340127
+
Hg19::chr12:2386467..2386484,+p@chr12:2386467..2386484
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Hg19::chr12:2468720..2468724,+p@chr12:2468720..2468724
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Hg19::chr13:31729140..31729163,-p@chr13:31729140..31729163
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Hg19::chr14:102550059..102550072,-p@chr14:102550059..102550072
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Hg19::chr14:102551390..102551436,-p10@HSP90AA1
Hg19::chr14:102551456..102551467,-p27@HSP90AA1
Hg19::chr14:92349687..92349698,-p@chr14:92349687..92349698
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Hg19::chr15:35082449..35082469,-p@chr15:35082449..35082469
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Hg19::chr15:86272097..86272099,+p@chr15:86272097..86272099
+
Hg19::chr16:10783399..10783401,+p@chr16:10783399..10783401
+
Hg19::chr17:77026478..77026512,+p@chr17:77026478..77026512
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Hg19::chr19:14628234..14628252,-p@chr19:14628234..14628252
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Hg19::chr19:2716727..2716731,-p10@DIRAS1
Hg19::chr1:159174559..159174571,+p3@DARC
Hg19::chr22:47045714..47045722,+p@chr22:47045714..47045722
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Hg19::chr3:46505091..46505110,-p5@LTF
Hg19::chr3:64517143..64517146,-p@chr3:64517143..64517146
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Hg19::chr3:64673668..64673684,-p1@ADAMTS9
Hg19::chr4:95332178..95332184,+p@chr4:95332178..95332184
+
Hg19::chr5:99385820..99385831,-p@chr5:99385820..99385831
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Hg19::chr5:99390735..99390743,-p@chr5:99390735..99390743
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Hg19::chr6:31785440..31785544,+p@chr6:31785440..31785544
+
Hg19::chr6:31785565..31785576,+p@chr6:31785565..31785576
+
Hg19::chr6:31797870..31797898,+p6@HSPA1B
Hg19::chr7:105926145..105926185,-p7@NAMPT
Hg19::chr7:105926216..105926230,-p10@NAMPT
Hg19::chr9:124095011..124095025,+p@chr9:124095011..124095025
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0042026protein refolding0.0216354645001766
GO:0030911TPR domain binding0.0260593848696238
GO:0030235nitric-oxide synthase regulator activity0.0260593848696238
GO:0009607response to biotic stimulus0.0260593848696238
GO:0045429positive regulation of nitric oxide biosynthetic process0.0346024795986266
GO:0045428regulation of nitric oxide biosynthetic process0.0360400055870461
GO:0006516glycoprotein catabolic process0.0475392087874602
GO:0006952defense response0.0475392087874602
GO:0046209nitric oxide metabolic process0.0475392087874602
GO:0006809nitric oxide biosynthetic process0.0475392087874602



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism3.65e-35115
neural tube3.58e-1957
neural rod3.58e-1957
future spinal cord3.58e-1957
neural keel3.58e-1957
central nervous system1.40e-1682
regional part of brain9.24e-1659
anterior neural tube8.88e-1542
brain1.27e-1469
future brain1.27e-1469
regional part of nervous system2.81e-1494
nervous system2.81e-1494
regional part of forebrain3.37e-1441
forebrain3.37e-1441
future forebrain3.37e-1441
organ4.32e-13511
neurectoderm2.47e-1290
neural plate4.76e-1286
presumptive neural plate4.76e-1286
gray matter1.43e-1134
brain grey matter1.43e-1134
anatomical conduit1.58e-11241
anatomical cluster1.71e-11286
telencephalon5.84e-1134
tube6.59e-11194
regional part of telencephalon7.80e-1133
cerebral hemisphere5.56e-1032
multi-cellular organism3.41e-09659
regional part of cerebral cortex2.73e-0822
anatomical system5.22e-08625
anatomical group7.04e-08626
pre-chordal neural plate2.45e-0761
cerebral cortex2.61e-0725
pallium2.61e-0725
neocortex2.94e-0720
embryo5.30e-07612


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.