Coexpression cluster:C3679

Full id: C3679_occipital_cord_postcentral_NK_paracentral_parietal_temporal

Phase1 CAGE Peaks

Hg19::chr17:74236414..74236423,-	p5@RNF157
Hg19::chr17:74236512..74236556,-	p2@RNF157
Hg19::chr17:74236559..74236626,-	p1@RNF157

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
mature alpha-beta T cell	1.49e-07	18
alpha-beta T cell	1.49e-07	18
immature T cell	1.49e-07	18
mature T cell	1.49e-07	18
immature alpha-beta T cell	1.49e-07	18
T cell	1.73e-07	25
pro-T cell	1.73e-07	25

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.02e-34	94
nervous system	1.02e-34	94
central nervous system	2.78e-32	82
adult organism	1.95e-31	115
neural tube	4.66e-30	57
neural rod	4.66e-30	57
future spinal cord	4.66e-30	57
neural keel	4.66e-30	57
brain	1.75e-27	69
future brain	1.75e-27	69
regional part of brain	1.18e-24	59
anterior neural tube	2.04e-23	42
neural plate	5.15e-23	86
presumptive neural plate	5.15e-23	86
regional part of forebrain	5.52e-23	41
forebrain	5.52e-23	41
future forebrain	5.52e-23	41
neurectoderm	2.03e-21	90
telencephalon	3.47e-20	34
gray matter	3.70e-20	34
brain grey matter	3.70e-20	34
regional part of telencephalon	1.73e-19	33
cerebral hemisphere	3.20e-19	32
pre-chordal neural plate	4.83e-19	61
ectoderm-derived structure	7.03e-19	169
ectoderm	4.71e-18	173
presumptive ectoderm	4.71e-18	173
anterior region of body	1.67e-17	129
craniocervical region	1.67e-17	129
head	2.19e-16	123
regional part of cerebral cortex	1.90e-15	22
cerebral cortex	2.40e-15	25
pallium	2.40e-15	25
neocortex	3.02e-14	20
organ part	5.95e-08	219
posterior neural tube	8.53e-08	15
chordal neural plate	8.53e-08	15
segmental subdivision of nervous system	9.88e-07	13

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0325005277384359
E2F4#1874	3	12.6680603152844	0.000491798700629898	0.00436685635904489
E2F6#1876	3	5.01715573169739	0.0079176980688633	0.0321819991676985
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0320354679071079
ESR1#2099	2	20.5124021974363	0.00309974157709518	0.016307370067008
FOS#2353	3	8.9979553088944	0.00137249927241713	0.00896955456554487
HDAC2#3066	3	13.4156202366263	0.000414076139985721	0.00390939233266757
NFYA#4800	3	18.4255806998305	0.000159813550781416	0.00199435624687064
NFYB#4801	3	16.7597932535365	0.000212364992329618	0.00245616693620299
SP1#6667	3	5.6983813781409	0.00540396270171217	0.024626252753474
SP2#6668	3	26.1535304938446	5.58768218891694e-05	0.000939426819266413
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0190122475343873
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0140045428079946

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.