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Coexpression cluster:C4022

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Full id: C4022_CD14_Eosinophils_Neutrophils_Basophils_migratory_epidermoid_Mast



Phase1 CAGE Peaks

Hg19::chr20:31407751..31407795,+p1@MAPRE1
Hg19::chr8:101964198..101964221,-p2@YWHAZ
Hg19::chr8:101964231..101964255,-p1@YWHAZ


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0031115negative regulation of microtubule polymerization0.00506284401442095
GO:0030981cortical microtubule cytoskeleton0.00506284401442095
GO:0051010microtubule plus-end binding0.00506284401442095
GO:0031113regulation of microtubule polymerization0.0101246447580706
GO:0046785microtubule polymerization0.0101246447580706
GO:0048523negative regulation of cellular process0.0140589016358978
GO:0048519negative regulation of biological process0.0140589016358978
GO:0031111negative regulation of microtubule polymerization or depolymerization0.0140589016358978
GO:0030863cortical cytoskeleton0.0140589016358978
GO:0031110regulation of microtubule polymerization or depolymerization0.0146766288835239
GO:0031109microtubule polymerization or depolymerization0.0147219867739274
GO:0044448cell cortex part0.0187912866763938
GO:0008017microtubule binding0.0187912866763938
GO:0051129negative regulation of cellular component organization and biogenesis0.0187912866763938
GO:0005938cell cortex0.0209860622386991
GO:0015631tubulin binding0.0209860622386991
GO:0008022protein C-terminus binding0.0209860622386991
GO:0005819spindle0.0209860622386991
GO:0048770pigment granule0.0209860622386991
GO:0042470melanosome0.0209860622386991
GO:0051258protein polymerization0.0224198953551073
GO:0051128regulation of cellular component organization and biogenesis0.0224198953551073
GO:0000226microtubule cytoskeleton organization and biogenesis0.0224198953551073
GO:0019904protein domain specific binding0.0267419858021847
GO:0006916anti-apoptosis0.0343427151346421
GO:0043066negative regulation of apoptosis0.0411992843938898
GO:0043069negative regulation of programmed cell death0.0411992843938898
GO:0007067mitosis0.0411992843938898
GO:0000087M phase of mitotic cell cycle0.0411992843938898
GO:0051301cell division0.0411992843938898
GO:0005874microtubule0.0466903559920029
GO:0000279M phase0.0466903559920029
GO:0044444cytoplasmic part0.0466903559920029
GO:0007017microtubule-based process0.0466903559920029
GO:0000278mitotic cell cycle0.0469325831757985
GO:0016023cytoplasmic membrane-bound vesicle0.0479180146242358
GO:0031988membrane-bound vesicle0.0479180146242358
GO:0022403cell cycle phase0.0488980343754735



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.