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Coexpression cluster:C4114

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Full id: C4114_lung_heart_Endothelial_kidney_Mesenchymal_placenta_squamous



Phase1 CAGE Peaks

  Short description
Hg19::chr2:102953710..102953727,+ p1@IL1RL1
Hg19::chr2:102953739..102953750,+ p5@IL1RL1
Hg19::chr2:102953753..102953765,+ p4@IL1RL1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism1.91e-20114
tube7.61e-17192
anatomical conduit2.91e-14240
blood vessel endothelium1.78e-1318
endothelium1.78e-1318
cardiovascular system endothelium1.78e-1318
cell layer9.46e-13309
epithelium2.13e-12306
simple squamous epithelium2.69e-1122
neural tube3.82e-1156
neural rod3.82e-1156
future spinal cord3.82e-1156
neural keel3.82e-1156
endothelial tube4.79e-119
arterial system endothelium4.79e-119
endothelium of artery4.79e-119
regional part of nervous system2.14e-1053
regional part of brain2.14e-1053
structure with developmental contribution from neural crest1.62e-09132
squamous epithelium3.12e-0925
brain1.82e-0868
future brain1.82e-0868
brain grey matter3.04e-0834
gray matter3.04e-0834
neural plate5.11e-0882
presumptive neural plate5.11e-0882
anatomical cluster5.99e-08373
central nervous system8.21e-0881
neurectoderm1.30e-0786
splanchnic layer of lateral plate mesoderm1.78e-0783
regional part of forebrain3.95e-0741
forebrain3.95e-0741
anterior neural tube3.95e-0741
future forebrain3.95e-0741
regional part of telencephalon4.65e-0732


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235338.99795530889440.001372499272417130.00899036951279306
JUN#3725312.51282919233630.0005103313992726250.00444858534418109
STAT3#6774310.51946499715420.0008589184530415310.00643504909018683



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.