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Coexpression cluster:C4132

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Full id: C4132_cord_Mast_mature_CD14_Neutrophils_Eosinophils_CD8



Phase1 CAGE Peaks

Hg19::chr2:145274900..145274934,-p4@ZEB2
Hg19::chr2:145274981..145274994,-p9@ZEB2
Hg19::chr2:145274998..145275012,-p13@ZEB2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
myeloid leukocyte1.54e-2976
myeloid lineage restricted progenitor cell9.29e-2670
CD14-positive, CD16-negative classical monocyte8.26e-2542
granulocyte monocyte progenitor cell2.61e-2371
myeloid cell2.64e-23112
common myeloid progenitor2.64e-23112
monopoietic cell4.58e-2263
monocyte4.58e-2263
monoblast4.58e-2263
promonocyte4.58e-2263
classical monocyte4.81e-2245
macrophage dendritic cell progenitor1.61e-2165
leukocyte6.63e-20140
hematopoietic stem cell3.46e-17172
angioblastic mesenchymal cell3.46e-17172
hematopoietic cell7.47e-17182
hematopoietic oligopotent progenitor cell7.76e-17165
hematopoietic multipotent progenitor cell7.76e-17165
mesenchymal cell1.62e-15358
motile cell1.65e-15390
hematopoietic lineage restricted progenitor cell1.97e-15124
connective tissue cell9.88e-15365
multi fate stem cell2.30e-14430
nongranular leukocyte5.18e-14119
somatic stem cell3.54e-13436
stem cell2.14e-12444
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.07e-26102
blood island3.07e-26102
hemolymphoid system7.48e-22112
bone marrow1.68e-2180
bone element1.54e-2086
adult organism4.77e-19115
skeletal element8.54e-19101
skeletal system8.54e-19101
neural tube1.39e-1557
neural rod1.39e-1557
future spinal cord1.39e-1557
neural keel1.39e-1557
connective tissue1.76e-15375
anterior neural tube2.37e-1542
regional part of forebrain6.41e-1541
forebrain6.41e-1541
future forebrain6.41e-1541
central nervous system7.58e-1582
telencephalon9.25e-1534
gray matter1.84e-1434
brain grey matter1.84e-1434
regional part of nervous system2.63e-1494
nervous system2.63e-1494
musculoskeletal system2.65e-14167
regional part of brain2.83e-1459
regional part of telencephalon3.42e-1433
cerebral hemisphere1.15e-1332
brain1.37e-1369
future brain1.37e-1369
tissue6.15e-11787
cerebral cortex1.58e-1025
pallium1.58e-1025
regional part of cerebral cortex1.81e-1022
neural plate1.93e-1086
presumptive neural plate1.93e-1086
immune system3.57e-10115
neurectoderm8.93e-1090
neocortex1.34e-0920
pre-chordal neural plate3.80e-0961
lateral plate mesoderm7.16e-09216
blood1.55e-0715
haemolymphatic fluid1.55e-0715
organism substance1.55e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538324.35780179230366.91705216281876e-050.00110039605610454
CEBPB#105137.971147625824820.001974187055288560.0115443517282912
FOS#235338.99795530889440.001372499272417130.00899149739756445
FOSL1#8061339.7135797163731.59554825631833e-050.000371626816105331
GATA1#2623313.56030814380040.0004009615963782630.00388460372580236
GATA2#2624312.7449317335540.0004829527704283790.00437497652795295
JUN#3725312.51282919233630.0005103313992726250.00444932807485046
JUNB#3726330.61063265982113.4847716247536e-050.000681164259250686
JUND#372736.994663941871030.002921845042734990.0157053306442717
NR3C1#2908314.9730233311730.0002978331194675480.00309321729952976
RAD21#5885310.35503389545630.0009004912073565420.00665391263655793
STAT3#6774310.51946499715420.0008589184530415310.0064359724721771
TFAP2A#7020316.5186343730450.0002218033880766340.00248684101420672
TFAP2C#7022310.80922860986020.0007916746575753130.00616889573696248
YY1#752834.911170749853860.008441455341808260.033002064626904



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.