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Coexpression cluster:C4242

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Full id: C4242_Myoblast_Preadipocyte_Chondrocyte_Mesenchymal_mesenchymal_mesothelioma_Adipocyte



Phase1 CAGE Peaks

  Short description
Hg19::chr2:69240302..69240332,+ p1@ANTXR1
Hg19::chr2:69240415..69240424,+ p5@ANTXR1
Hg19::chr2:69240547..69240561,+ p4@ANTXR1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
multi-tissue structure2.85e-18342
muscle tissue1.22e-1564
musculature1.22e-1564
musculature of body1.22e-1564
paraxial mesoderm1.95e-1572
presumptive paraxial mesoderm1.95e-1572
somite2.02e-1571
presomitic mesoderm2.02e-1571
presumptive segmental plate2.02e-1571
dermomyotome2.02e-1571
trunk paraxial mesoderm2.02e-1571
dense mesenchyme tissue2.04e-1573
skeletal muscle tissue2.30e-1562
striated muscle tissue2.30e-1562
myotome2.30e-1562
multi-cellular organism7.81e-15656
epithelial vesicle1.55e-1478
trunk mesenchyme7.27e-14122
anatomical cluster2.21e-13373
mesenchyme3.09e-13160
entire embryonic mesenchyme3.09e-13160
multilaminar epithelium2.40e-1283
splanchnic layer of lateral plate mesoderm1.57e-1183
epithelium1.59e-11306
cell layer2.28e-11309
artery3.43e-1042
arterial blood vessel3.43e-1042
arterial system3.43e-1042
anatomical system7.56e-10624
anatomical group1.19e-09625
systemic artery1.71e-0933
systemic arterial system1.71e-0933
vasculature3.46e-0978
vascular system3.46e-0978
structure with developmental contribution from neural crest3.53e-09132
embryonic structure3.88e-09564
germ layer4.12e-09560
germ layer / neural crest4.12e-09560
embryonic tissue4.12e-09560
presumptive structure4.12e-09560
germ layer / neural crest derived structure4.12e-09560
epiblast (generic)4.12e-09560
epithelial tube open at both ends1.37e-0859
blood vessel1.37e-0859
blood vasculature1.37e-0859
vascular cord1.37e-0859
trunk1.65e-08199
tube2.03e-08192
unilaminar epithelium2.08e-08148
anatomical conduit2.82e-08240
organism subdivision9.53e-08264
developing anatomical structure1.63e-07581
vessel3.47e-0768
cardiovascular system5.05e-07109
embryo7.61e-07592
heart9.15e-0724
primitive heart tube9.15e-0724
primary heart field9.15e-0724
anterior lateral plate mesoderm9.15e-0724
heart tube9.15e-0724
heart primordium9.15e-0724
cardiac mesoderm9.15e-0724
cardiogenic plate9.15e-0724
heart rudiment9.15e-0724
circulatory system9.25e-07112
integument9.47e-0746
integumental system9.47e-0746


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.11.90116
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.112.4986
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.13.923
MA0074.10.935474
MA0076.11.74184
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.12.48891
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.28.812
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0280298943346589
CTCFL#140690213.16431623931620.007433367036996010.0306899675828916
ELK4#2005316.2356816584680.0002336043955745990.00256087010280419
GABPB1#255337.067683836182170.002832212825417420.0154501684655926
HDAC2#3066313.41562023662630.0004140761399857210.00392357992959251
MAX#414936.452555509007120.003721913834265510.0187025095716347
NR2C2#7182332.61461090524092.88098172333076e-050.000605771794247919
RAD21#5885310.35503389545630.0009004912073565420.00665956671895694
SIX5#147912317.0867153554590.0002004060546325010.00240052849406627
SMC3#9126315.04493284493280.0002935825420371870.00309836975624714
YY1#752834.911170749853860.008441455341808260.0330255536408733
ZBTB7A#5134137.35190930787590.002516255860282270.0140562283799754



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.