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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0.0724992894770213,0
 

Latest revision as of 05:17, 17 September 2013


Full id: C4678_Smooth_Mesothelial_glioma_mesenchymal_Renal_liposarcoma_Hepatic



Phase1 CAGE Peaks

Hg19::chr7:27157834..27157879,-p@chr7:27157834..27157879
-
Hg19::chr7:27157924..27157950,-p@chr7:27157924..27157950
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Hg19::chr7:27157970..27157995,-p@chr7:27157970..27157995
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
subdivision of trunk4.19e-16112
nephron tubule epithelium8.58e-1610
trunk2.35e-15199
mesenchyme5.77e-15160
entire embryonic mesenchyme5.77e-15160
excretory tube5.94e-1516
kidney epithelium5.94e-1516
cavitated compound organ9.16e-1531
epithelial tube1.72e-14117
smooth muscle tissue2.65e-1415
nephron epithelium5.37e-1415
renal tubule5.37e-1415
nephron tubule5.37e-1415
nephron5.37e-1415
uriniferous tubule5.37e-1415
nephrogenic mesenchyme5.37e-1415
kidney1.35e-1326
kidney mesenchyme1.35e-1326
upper urinary tract1.35e-1326
kidney rudiment1.35e-1326
kidney field1.35e-1326
abdominal segment of trunk1.45e-1260
abdomen1.45e-1260
muscle tissue1.72e-1164
musculature1.72e-1164
musculature of body1.72e-1164
compound organ3.53e-1168
tube3.53e-11192
systemic artery1.03e-1033
systemic arterial system1.03e-1033
multi-tissue structure1.20e-10342
organism subdivision1.21e-10264
trunk region element2.28e-10101
skeletal muscle tissue3.04e-1062
striated muscle tissue3.04e-1062
myotome3.04e-1062
epithelial vesicle4.65e-1078
cortex of kidney8.23e-1012
renal parenchyma8.23e-1012
blood vessel smooth muscle1.20e-0910
arterial system smooth muscle1.20e-0910
artery smooth muscle tissue1.20e-0910
aorta smooth muscle tissue1.20e-0910
anatomical cluster2.93e-09373
immaterial anatomical entity4.35e-09117
trunk mesenchyme4.67e-09122
abdomen element5.54e-0954
abdominal segment element5.54e-0954
anatomical space1.61e-0895
artery3.39e-0842
arterial blood vessel3.39e-0842
arterial system3.39e-0842
somite5.08e-0871
presomitic mesoderm5.08e-0871
presumptive segmental plate5.08e-0871
dermomyotome5.08e-0871
trunk paraxial mesoderm5.08e-0871
paraxial mesoderm8.21e-0872
presumptive paraxial mesoderm8.21e-0872
epithelium8.71e-08306
posterior neural tube1.04e-0715
chordal neural plate1.04e-0715
dense mesenchyme tissue1.31e-0773
cell layer1.53e-07309
cortex2.12e-0715
parenchyma2.12e-0715
anatomical conduit2.44e-07240
urinary system structure5.14e-0747
aorta7.73e-0721
aortic system7.73e-0721
renal system9.10e-0748
Disease
Ontology termp-valuen
ovarian cancer9.42e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.13.20493
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.12.76432
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.15.50871
MA0059.11.70014
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.12.1667
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.19.66582
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.13.82193
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.13.45103
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.22.07011
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.122425
MA0164.12.32251
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.69213
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SUZ12#23512233.41052060737530.00117826764536030.0080031929379412
USF1#739136.361499277207960.00388404057290560.0191152779507887



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.