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Coexpression cluster:C473


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Full id: C473_immature_Eosinophils_cord_CD14_CD4_CD8_Natural

Phase1 CAGE Peaks

  Short description
Hg19::chr10:106028656..106028685,- p1@MIR4482-1
Hg19::chr10:3827776..3827787,+ p@chr10:3827776..3827787
Hg19::chr11:18548217..18548243,+ p@chr11:18548217..18548243
Hg19::chr11:58346354..58346370,- p@chr11:58346354..58346370
Hg19::chr12:25539298..25539317,+ p@chr12:25539298..25539317
Hg19::chr13:45151945..45151990,- p@chr13:45151945..45151990
Hg19::chr14:24583688..24583704,- p@chr14:24583688..24583704
Hg19::chr16:20912197..20912222,- p4@DCUN1D3
Hg19::chr19:49376263..49376332,- p@chr19:49376263..49376332
Hg19::chr1:171455122..171455146,- p1@BC007549
Hg19::chr2:96811170..96811186,- p1@DUSP2
Hg19::chr3:150126416..150126437,+ p3@TSC22D2
Hg19::chr3:5020939..5020952,+ p2@BHLHE40
Hg19::chr4:103461950..103461953,+ p@chr4:103461950..103461953
Hg19::chr6:108879688..108879712,- p@chr6:108879688..108879712
Hg19::chr7:151216229..151216250,+ p@chr7:151216229..151216250
Hg19::chr7:73508557..73508570,- p@chr7:73508557..73508570
Hg19::chr8:102218439..102218455,- p3@ZNF706
Hg19::chr8:81397846..81397860,+ p3@ZBTB10
Hg19::chr8:81397876..81397898,+ p5@ZBTB10

Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset

No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset

GO IDGO nameFDR corrected p-value
GO:0051019mitogen-activated protein kinase binding0.0135982338777593
GO:0008330protein tyrosine/threonine phosphatase activity0.0135982338777593
GO:0033549MAP kinase phosphatase activity0.0326141514013656
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity0.0326141514013656
GO:0000188inactivation of MAPK activity0.0326141514013656
GO:0043407negative regulation of MAP kinase activity0.0362283455576895

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


Cell Type
Ontology termp-valuen
hematopoietic stem cell3.56e-47172
angioblastic mesenchymal cell3.56e-47172
hematopoietic cell6.40e-46182
hematopoietic oligopotent progenitor cell4.88e-43165
hematopoietic multipotent progenitor cell4.88e-43165
hematopoietic lineage restricted progenitor cell7.55e-42124
nongranular leukocyte2.28e-41119
myeloid leukocyte1.33e-2476
CD14-positive, CD16-negative classical monocyte1.67e-2442
classical monocyte4.02e-2445
granulocyte monocyte progenitor cell1.21e-2171
myeloid cell1.64e-21112
common myeloid progenitor1.64e-21112
common lymphoid progenitor1.09e-2053
lymphoid lineage restricted progenitor cell2.08e-2052
myeloid lineage restricted progenitor cell1.48e-1970
macrophage dendritic cell progenitor2.00e-1965
monopoietic cell2.54e-1863
T cell1.05e-1025
pro-T cell1.05e-1025
mesenchymal cell1.69e-10358
connective tissue cell4.81e-10365
mature alpha-beta T cell5.41e-1018
alpha-beta T cell5.41e-1018
immature T cell5.41e-1018
mature T cell5.41e-1018
immature alpha-beta T cell5.41e-1018
lymphocyte of B lineage4.34e-0924
pro-B cell4.34e-0924
B cell3.10e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.81e-27102
blood island1.81e-27102
hemolymphoid system2.58e-24112
bone marrow8.42e-2080
bone element1.32e-1886
immune system7.76e-17115
skeletal element7.36e-12101
skeletal system7.36e-12101
connective tissue7.78e-10375

Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs

Jaspar motifs

Novel motifs

JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset


No analysis results for this cluster

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.

link to data source

This analysis result is provided for C0 - C305 clusters.