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Coexpression cluster:C811

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Full id: C811_Smooth_Fibroblast_Preadipocyte_Chondrocyte_hepatic_basal_Adipocyte



Phase1 CAGE Peaks

Hg19::chr12:104443890..104443971,-p1@GLT8D2
Hg19::chr12:99038511..99038575,-p1@IKBIP
Hg19::chr1:162602244..162602289,+p1@DDR2
Hg19::chr2:179343268..179343338,-p1@FKBP7
Hg19::chr2:190044480..190044494,-p1@COL5A2
Hg19::chr3:52739588..52739621,-p2@GLT8D1
Hg19::chr5:143550159..143550236,-p1@YIPF5
Hg19::chr5:54455989..54456019,+p1@GPX8
Hg19::chr7:128379390..128379447,+p1@CALU
Hg19::chr7:30066233..30066332,-p1@FKBP14


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005788endoplasmic reticulum lumen4.61097154483163e-05
GO:0044432endoplasmic reticulum part0.000235163406472688
GO:0005783endoplasmic reticulum0.00139924532238113
GO:0003755peptidyl-prolyl cis-trans isomerase activity0.00533970528070001
GO:0016859cis-trans isomerase activity0.00533970528070001
GO:0016051carbohydrate biosynthetic process0.00978051326245874
GO:0005588collagen type V0.013117345110061
GO:0031974membrane-enclosed lumen0.0169083956011319
GO:0043233organelle lumen0.0169083956011319
GO:0043588skin development0.0183586078254092
GO:0016758transferase activity, transferring hexosyl groups0.0218303482719949
GO:0016853isomerase activity0.0235269792804304
GO:0030199collagen fibril organization0.0235269792804304
GO:0005583fibrillar collagen0.0239659625334093
GO:0006457protein folding0.0239659625334093
GO:0005509calcium ion binding0.0305126129548744
GO:0031410cytoplasmic vesicle0.0308570937043425
GO:0031982vesicle0.0308570937043425
GO:0016757transferase activity, transferring glycosyl groups0.0308570937043425



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
somite1.14e-2383
paraxial mesoderm1.14e-2383
presomitic mesoderm1.14e-2383
presumptive segmental plate1.14e-2383
trunk paraxial mesoderm1.14e-2383
presumptive paraxial mesoderm1.14e-2383
dermomyotome4.74e-2070
multilaminar epithelium7.81e-1982
skeletal muscle tissue6.31e-1861
striated muscle tissue6.31e-1861
myotome6.31e-1861
muscle tissue1.20e-1763
musculature1.20e-1763
musculature of body1.20e-1763
trunk mesenchyme5.94e-17143
splanchnic layer of lateral plate mesoderm6.52e-1684
organism subdivision9.77e-15365
vasculature1.11e-1479
vascular system1.11e-1479
trunk2.07e-14216
unilaminar epithelium2.99e-13138
surface structure9.38e-1395
blood vessel6.16e-1260
epithelial tube open at both ends6.16e-1260
blood vasculature6.16e-1260
vascular cord6.16e-1260
multi-cellular organism1.06e-11659
vessel1.24e-1169
artery2.14e-1142
arterial blood vessel2.14e-1142
arterial system2.14e-1142
mesenchyme3.36e-11238
entire embryonic mesenchyme3.36e-11238
multi-tissue structure7.51e-11347
integument8.50e-1145
integumental system8.50e-1145
cardiovascular system1.35e-10110
circulatory system2.07e-10113
epithelial tube4.03e-10118
systemic artery4.10e-1033
systemic arterial system4.10e-1033
skin of body1.83e-0940
cell layer8.63e-09312
epithelium2.60e-08309
anatomical system5.26e-08625
anatomical group7.25e-08626
heart5.59e-0724
primitive heart tube5.59e-0724
primary heart field5.59e-0724
anterior lateral plate mesoderm5.59e-0724
heart tube5.59e-0724
heart primordium5.59e-0724
cardiac mesoderm5.59e-0724
cardiogenic plate5.59e-0724
heart rudiment5.59e-0724
Disease
Ontology termp-valuen
ovarian cancer6.70e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90553.168100788481320.01227157669794290.0444810050587048
CEBPB#105164.782688575494890.0005200755356730160.00450569629781453
GTF2B#295939.583148980297270.00311863167294360.0163910610080296
IRF1#365953.818581876781950.005465628575453730.0247571142295968
MXI1#460143.984628651503720.01296562982531040.0460130284184168
POLR2A#5430102.147453176558070.0004793377491637920.00436532570499802
SIN3A#2594263.245330836089080.004223840630485730.0201027019507519
TAF1#687282.674437028596230.001556617278062390.00988457177014395
TBP#690872.594739480967470.00558866901773640.0252738808150763
TRIM28#1015535.577157513578760.01403197805233580.0492484375376517



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.