Coexpression cluster:C893

Full id: C893_osteoclastoma_Urothelial_tubular_nonsmall_Mesenchymal_Renal_hepatic

Phase1 CAGE Peaks

Hg19::chr12:47473475..47473484,-	p9@AMIGO2
Hg19::chr12:47473520..47473544,-	p3@AMIGO2
Hg19::chr12:47473557..47473568,-	p8@AMIGO2
Hg19::chr12:47473642..47473653,-	p7@AMIGO2
Hg19::chr12:47473707..47473757,-	p1@AMIGO2
Hg19::chr12:47473898..47473903,-	p11@AMIGO2
Hg19::chr12:47473904..47473917,-	p6@AMIGO2
Hg19::chr12:47473920..47473939,-	p5@AMIGO2
Hg19::chr12:47474192..47474251,-	p4@AMIGO2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	1.31e-12	253
endo-epithelial cell	1.38e-11	42
endodermal cell	6.61e-08	58
embryonic cell	1.09e-07	250
kidney tubule cell	4.43e-07	10
nephron tubule epithelial cell	4.43e-07	10

Uber Anatomy

Ontology term	p-value	n
trunk	2.37e-13	199
organism subdivision	2.96e-13	264
anatomical space	9.26e-09	95
subdivision of trunk	1.72e-08	112
immaterial anatomical entity	4.50e-08	117
female organism	4.80e-08	41
body cavity precursor	8.96e-08	54
multi-tissue structure	1.19e-07	342
epithelial bud	1.65e-07	37
endo-epithelium	3.20e-07	82
body cavity	4.12e-07	46
cell layer	4.41e-07	309
nephron tubule epithelium	4.43e-07	10
epithelial tube	5.15e-07	117
reproductive structure	5.91e-07	59
reproductive system	5.91e-07	59
epithelial fold	8.62e-07	47
renal system	9.24e-07	48
female reproductive organ	9.85e-07	37
female reproductive system	9.85e-07	37

Disease

Ontology term	p-value	n
female reproductive organ cancer	2.59e-11	27
reproductive organ cancer	9.75e-11	29
ovarian cancer	1.44e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	7	6.19978148675264	1.39459740509258e-05	0.000336530402935453
E2F6#1876	8	4.45969398373101	1.843503537119e-05	0.000419006889908969
FOXA1#3169	4	4.92507544417131	0.00575815054200309	0.0259291805482801
GABPB1#2553	5	3.92649102010121	0.00433797609228731	0.0205849373030303
GTF2F1#2962	7	9.90862512636706	5.7263614460198e-07	2.63925623592614e-05
NR3C1#2908	5	8.31834629509613	0.000133141846723398	0.00174886194566029
POLR2A#5430	9	2.14745317655807	0.00102941289260802	0.00728541391143792
ZBTB7A#51341	9	7.3519093078759	1.59170049418346e-08	1.16411490134473e-06

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.