ApprovedSymbol HGNCID ApprovedName UniProtAC UniProt_SL HPRD_SL HPRD_SL.PMID LocTree3_Localization LocTree3_Score TMHsPredicted_PolyPhobius Consensus_SL 6class_consensus_SL Taxon.Wagner Taxon.Dollo Taxon.Tautz2013 A1BG HGNC:5 alpha-1-B glycoprotein P04217 Secreted. Extracellular (GO:0005576) 3610142 secreted 100 0 secreted secreted Eutheria Eutheria Euteleostomi A1CF HGNC:24086 APOBEC1 complementation factor Q9NQ94 Nucleus. Endoplasmic reticulum (By similarity). Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10833526,12881431,12896982,10833526,12881431,12896982 nucleus 51 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms A2M HGNC:7 alpha-2-macroglobulin P01023 Secreted. Extracellular (GO:0005576); Cytosol (GO:0005829) 11823454,9831625,16199891,16188874,15561729 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Deuterostomia Cell.Organisms A2ML1 HGNC:23336 alpha-2-macroglobulin-like 1 A8K2U0 Secreted. Cytoplasmic vesicle (GO:0016023) 16298998 secreted 100 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms A4GALT HGNC:18149 alpha 1,4-galactosyltransferase Q9NPC4 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 10748143,10747952 secreted 36 1 golgi apparatus. golgi apparatus membrane. plasma membrane multiple Tetrapoda Eukaryota Cell.Organisms A4GNT HGNC:17968 alpha-1,4-N-acetylglucosaminyltransferase Q9UNA3 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) 10430883 golgi apparatus membrane 16 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Tetrapoda Cell.Organisms AAAS HGNC:13666 achalasia, adrenocortical insufficiency, alacrimia Q9NRG9 Peroxisome (GO:0005777); Nuclear membrane (GO:0005635) 11159947,15561729 nucleus 26 1 nucleus membrane. peroxisome multiple Eutheria Eukaryota Cell.Organisms AACS HGNC:21298 acetoacetyl-CoA synthetase Q86V21 Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737) 12623130,4073493 cytoplasm 9 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms AADAC HGNC:17 arylacetamide deacetylase P22760 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 8063807 secreted 40 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms AADACL2 HGNC:24427 arylacetamide deacetylase-like 2 Q6P093 Secreted. secreted 100 2 secreted secreted Eutheria Eukaryota NA AADACL3 HGNC:32037 arylacetamide deacetylase-like 3 Q5VUY0 secreted 18 2 n/a n/a Cell.Organisms Cell.Organisms Cell.Organisms AADACL4 HGNC:32038 arylacetamide deacetylase-like 4 Q5VUY2 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) secreted 15 0 secreted secreted Cell.Organisms Cell.Organisms Cell.Organisms AADAT HGNC:17929 aminoadipate aminotransferase Q8N5Z0 Mitochondrion (Potential). Mitochondrion (GO:0005739) 8087205,12126930,1798692 cytoplasm 28 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms AAED1 HGNC:16881 AhpC/TSA antioxidant enzyme domain containing 1 Q7RTV5 cytoplasm 16 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota AAGAB HGNC:25662 alpha- and gamma-adaptin binding protein Q6PD74 Cytoplasm, cytosol. Nucleus (GO:0005634) 17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta AAK1 HGNC:19679 AP2 associated kinase 1 Q2M2I8 Cell membrane; Peripheral membrane protein (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity). Cytoskeleton (GO:0005856); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11877461,17081983,17081983 nucleus 38 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms AAMDC HGNC:30205 adipogenesis associated, Mth938 domain containing Q9H7C9 Cytoplasm (By similarity). Note=Diffuse distribution with some highly concentrated spots around the nucleus (By similarity). cytoplasm 90 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms AAMP HGNC:18 angio-associated, migratory cell protein Q13685 Cell membrane. Cytoplasm. Extracellular (GO:0005576) 10329261,11969303 cytoplasm 8 0 cytoplasm. secreted multiple Eukaryota Eukaryota Cell.Organisms AANAT HGNC:19 aralkylamine N-acetyltransferase Q16613 Cytoplasm. Cytoplasm (GO:0005737) 11313340 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Eukaryota AAR2 HGNC:15886 AAR2 splicing factor homolog (S. cerevisiae) Q9Y312 nucleus 38 0 nucleus nucleus Eukaryota Eukaryota Eukaryota AARD HGNC:33842 alanine and arginine rich domain containing protein Q4LEZ3 mitochondrion 30 0 mitochondrion mitochondrion Euarchontoglires Eutheria Eutheria AARS HGNC:20 alanyl-tRNA synthetase P49588 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 11532948,11532948,16263121 mitochondrion 34 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms AARS2 HGNC:21022 alanyl-tRNA synthetase 2, mitochondrial Q5JTZ9 Mitochondrion. Mitochondrion (GO:0005739) 15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms AARSD1 HGNC:28417 alanyl-tRNA synthetase domain containing 1 Q9BTE6 Cytoplasm (By similarity). mitochondrion 14 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms NA AASDH HGNC:23993 aminoadipate-semialdehyde dehydrogenase Q4L235 cytoplasm 7 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms AASDHPPT HGNC:14235 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Q9NRN7 Cytoplasm. Cytoplasm (GO:0005737) 12815048 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms AASS HGNC:17366 aminoadipate-semialdehyde synthase Q9UDR5 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 10567240 mitochondrion 84 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms AATF HGNC:19235 apoptosis antagonizing transcription factor Q9NY61 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 12847090,14627703,17081983,14627703,17081983,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota AATK HGNC:21 apoptosis-associated tyrosine kinase Q6ZMQ8 Membrane; Single-pass type I membrane protein (By similarity). Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 10837911,12670708 plasma membrane 16 1 cytoplasm. endoplasmic reticulum multiple Theria Euteleostomi Cell.Organisms ABAT HGNC:23 4-aminobutyrate aminotransferase P80404 Mitochondrion matrix. Mitochondrion (GO:0005739) 6470007 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms ABCA1 HGNC:29 ATP-binding cassette, sub-family A (ABC1), member 1 O95477 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Intracellular vesicle (None) 12509412,14722086,18484747,,12054535, endoplasmic reticulum membrane 17 14 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCA10 HGNC:30 ATP-binding cassette, sub-family A (ABC1), member 10 Q8WWZ4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12821155 endoplasmic reticulum membrane 15 13 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms ABCA12 HGNC:14637 ATP-binding cassette, sub-family A (ABC1), member 12 Q86UK0 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12697999 endoplasmic reticulum membrane 16 18 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCA13 HGNC:14638 ATP-binding cassette, sub-family A (ABC1), member 13 Q86UQ4 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) nucleus 15 14 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms ABCA2 HGNC:32 ATP-binding cassette, sub-family A (ABC1), member 2 Q9BZC7 Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Forms discrete, punctate intracellular vesicles. Lysosome (GO:0005764); Cytoplasm (GO:0005737) 11309290,15093135,17081983 nucleus 14 14 cytoplasm. endosome membrane. lysosome. lysosome membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ABCA3 HGNC:33 ATP-binding cassette, sub-family A (ABC1), member 3 Q99758 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11940594,11718719 endoplasmic reticulum membrane 15 14 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCA4 HGNC:34 ATP-binding cassette, sub-family A (ABC1), member 4 P78363 Membrane; Multi-pass membrane protein. Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. Plasma membrane (GO:0005886) 9703434,9288089 endoplasmic reticulum membrane 14 16 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCA5 HGNC:35 ATP-binding cassette, sub-family A (ABC1), member 5 Q8WWZ7 Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) 11435397 endoplasmic reticulum membrane 20 14 endosome membrane. lysosome membrane multiple Deuterostomia Cell.Organisms Cell.Organisms ABCA6 HGNC:36 ATP-binding cassette, sub-family A (ABC1), member 6 Q8N139 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 15 14 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms ABCA7 HGNC:37 ATP-binding cassette, sub-family A (ABC1), member 7 Q8IZY2 Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 14592415,14592415 endoplasmic reticulum membrane 14 14 endoplasmic reticulum. endosome membrane. golgi apparatus membrane. plasma membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ABCA8 HGNC:38 ATP-binding cassette, sub-family A (ABC1), member 8 O94911 Cell membrane; Multi-pass membrane protein (Probable). endoplasmic reticulum membrane 14 15 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms ABCA9 HGNC:39 ATP-binding cassette, sub-family A (ABC1), member 9 Q8IUA7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11435397,12150964 endoplasmic reticulum membrane 16 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms ABCB1 HGNC:40 ATP-binding cassette, sub-family B (MDR/TAP), member 1 P08183 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 8898203 plasma membrane 84 12 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCB10 HGNC:41 ATP-binding cassette, sub-family B (MDR/TAP), member 10 Q9NRK6 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10922475,15598749 mitochondrion membrane 100 6 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ABCB11 HGNC:42 ATP-binding cassette, sub-family B (MDR/TAP), member 11 O95342 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11172067,9545351 plasma membrane 40 12 plasma membrane plasma membrane Cell.Organisms Cell.Organisms NA ABCB4 HGNC:45 ATP-binding cassette, sub-family B (MDR/TAP), member 4 P21439 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8898203 plasma membrane 100 12 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCB5 HGNC:46 ATP-binding cassette, sub-family B (MDR/TAP), member 5 Q2M3G0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12960149 plasma membrane 100 6 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms ABCB6 HGNC:47 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Q9NP58 Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Mitochondrion (GO:0005739) 10837493 mitochondrion membrane 31 11 endoplasmic reticulum. golgi apparatus. mitochondrion. mitochondrion membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCB7 HGNC:48 ATP-binding cassette, sub-family B (MDR/TAP), member 7 O75027 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) 10196363 mitochondrion membrane 44 6 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ABCB8 HGNC:49 ATP-binding cassette, sub-family B (MDR/TAP), member 8 Q9NUT2 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9878413 mitochondrion membrane 100 6 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ABCB9 HGNC:50 ATP-binding cassette, sub-family B (MDR/TAP), member 9 Q9NP78 Lysosome membrane; Multi-pass membrane protein. Note=May be located in membrane rafts. Lysosome (GO:0005764) 10748049 endoplasmic reticulum membrane 28 11 lysosome. lysosome membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ABCC1 HGNC:51 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 P33527 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 7916458,12925771,12925771,12897808 plasma membrane 100 17 cytoplasm. lysosome. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCC10 HGNC:52 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 Q5T3U5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 17 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCC11 HGNC:14639 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 Q96J66 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 13 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCC12 HGNC:14640 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 Q96J65 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12011458 plasma membrane 20 12 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCC2 HGNC:53 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Q92887 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11745434,11677213,11076395,17081983,17081983 plasma membrane 36 17 cytoplasm. nucleus. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCC3 HGNC:54 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 O15438 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10094960,10362653,9813153,11745434 plasma membrane 47 17 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCC4 HGNC:55 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 O15439 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12883481,17081983,17081983 vacuole membrane 23 12 cytoplasm. nucleus. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCC5 HGNC:56 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 O15440 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Apical membrane (GO:0016327); Nucleus (GO:0005634) 10840050,9827529,15631998,17081983 plasma membrane 21 14 nucleus. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCC6 HGNC:57 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 O95255 Membrane; Multi-pass membrane protein (By similarity). Note=Localized to the basolateral membrane. Plasma membrane (GO:0005886) 10835642 plasma membrane 100 17 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCC8 HGNC:59 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Q09428 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7502040 plasma membrane 20 17 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCC9 HGNC:60 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 O60706 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Microsome (GO:0005792) 12738227,12738227 plasma membrane 18 17 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCD1 HGNC:61 ATP-binding cassette, sub-family D (ALD), member 1 P33897 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 8004093,7668254,10777694 peroxisome membrane 100 6 peroxisome. peroxisome membrane multiple Bilateria Eukaryota NA ABCD2 HGNC:66 ATP-binding cassette, sub-family D (ALD), member 2 Q9UBJ2 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 10777694,10551832,10329405 peroxisome membrane 100 7 peroxisome. peroxisome membrane multiple Bilateria Eukaryota Cell.Organisms ABCD3 HGNC:67 ATP-binding cassette, sub-family D (ALD), member 3 P28288 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 8453064,15561729,15598749 peroxisome membrane 100 7 mitochondrion. peroxisome. peroxisome membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCD4 HGNC:68 ATP-binding cassette, sub-family D (ALD), member 4 O14678 Peroxisome membrane; Multi-pass membrane protein. Peroxisomal membrane (GO:0005778) 9302272,9521874 peroxisome membrane 100 6 peroxisomal membrane. peroxisome membrane multiple Deuterostomia Bilateria Cell.Organisms ABCE1 HGNC:69 ATP-binding cassette, sub-family E (OABP), member 1 P61221 Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11585831,11585831 nucleus 20 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms ABCF1 HGNC:70 ATP-binding cassette, sub-family F (GCN20), member 1 Q8NE71 Isoform 2: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Ribosome (GO:0005840); Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 10931828,17081983,17081983/17081983 cytoplasm 25 0 cytoplasm. nucleus multiple Theria Cell.Organisms NA ABCF2 HGNC:71 ATP-binding cassette, sub-family F (GCN20), member 2 Q9UG63 Mitochondrion (GO:0005739); Peroxisome (GO:0005777) 9878413,10922475,15561729 cytoplasm 35 0 mitochondrion. peroxisome multiple Eukaryota Cell.Organisms Cell.Organisms ABCF3 HGNC:72 ATP-binding cassette, sub-family F (GCN20), member 3 Q9NUQ8 cytoplasm 35 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ABCG1 HGNC:73 ATP-binding cassette, sub-family G (WHITE), member 1 P45844 Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. Cell surface (GO:0009986); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471);Cell surface (GO:0009986) 11350058,10639163,10639163,15994327,11350058,11350058,10639163/16870176 mitochondrion 17 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. mitochondrion. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ABCG2 HGNC:74 ATP-binding cassette, sub-family G (WHITE), member 2 Q9UNQ0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11309308 plasma membrane 100 7 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ABCG4 HGNC:13884 ATP-binding cassette, sub-family G (WHITE), member 4 Q9H172 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) 11856881 nucleus 17 7 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms ABCG5 HGNC:13886 ATP-binding cassette, sub-family G (WHITE), member 5 Q9H222 Membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 12208867,12208867,12208867 vacuole membrane 14 7 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms ABCG8 HGNC:13887 ATP-binding cassette, sub-family G (WHITE), member 8 Q9H221 Membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 12208867,12208867,12208867 endoplasmic reticulum membrane 19 6 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Euteleostomi Eukaryota Cell.Organisms ABHD1 HGNC:17553 abhydrolase domain containing 1 Q96SE0 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) secreted 21 2 n/a n/a Eukaryota Cell.Organisms Cell.Organisms ABHD10 HGNC:25656 abhydrolase domain containing 10 Q9NUJ1 Mitochondrion (Potential). mitochondrion 68 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms ABHD11 HGNC:16407 abhydrolase domain containing 11 Q8NFV4 mitochondrion 22 0 mitochondrion mitochondrion Eukaryota Cell.Organisms NA ABHD12 HGNC:15868 abhydrolase domain containing 12 Q8N2K0 Membrane; Single-pass membrane protein (By similarity). secreted 60 1 secreted secreted Chordata Cell.Organisms Cell.Organisms ABHD12B HGNC:19837 abhydrolase domain containing 12B Q7Z5M8 secreted 51 1 secreted secreted Chordata Cell.Organisms Cell.Organisms ABHD13 HGNC:20293 abhydrolase domain containing 13 Q7L211 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 11 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms ABHD14A HGNC:24538 abhydrolase domain containing 14A Q9BUJ0 Cytoplasm (By similarity). Membrane; Single- pass type II membrane protein (Potential). endoplasmic reticulum membrane 20 2 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Cell.Organisms ABHD14B HGNC:28235 abhydrolase domain containing 14B Q96IU4 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. mitochondrion 73 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms ABHD15 HGNC:26971 abhydrolase domain containing 15 Q6UXT9 Secreted (Potential). Integral to membrane (GO:0016021) secreted 18 0 secreted secreted Theria Euteleostomi Cell.Organisms ABHD16A HGNC:13921 abhydrolase domain containing 16A O95870 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion 0 3 mitochondrion mitochondrion Bilateria Bilateria NA ABHD16B HGNC:16128 abhydrolase domain containing 16B Q9H3Z7 secreted 42 0 secreted secreted Mammalia Mammalia Cell.Organisms ABHD17A HGNC:28756 abhydrolase domain containing 17A Q96GS6 Secreted (Potential). secreted 74 0 secreted secreted Eukaryota Eukaryota Cell.Organisms ABHD17B HGNC:24278 abhydrolase domain containing 17B Q5VST6 Secreted (Potential). secreted 78 0 secreted secreted Eukaryota Eukaryota Cell.Organisms ABHD17C HGNC:26925 abhydrolase domain containing 17C Q6PCB6 secreted 84 0 secreted secreted Eukaryota Eukaryota Cell.Organisms ABHD2 HGNC:18717 abhydrolase domain containing 2 P08910 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) 11922611 secreted 48 2 n/a n/a Deuterostomia Eukaryota Cell.Organisms ABHD3 HGNC:18718 abhydrolase domain containing 3 Q8WU67 Membrane; Single-pass type II membrane protein (Potential). secreted 16 2 n/a n/a Eukaryota Cell.Organisms Cell.Organisms ABHD4 HGNC:20154 abhydrolase domain containing 4 Q8TB40 mitochondrion 15 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ABHD5 HGNC:21396 abhydrolase domain containing 5 Q8WTS1 Cytoplasm. Lipid droplet (By similarity). Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity). Cytoplasm (GO:0005737) 15136565 mitochondrion 12 1 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms ABHD6 HGNC:21398 abhydrolase domain containing 6 Q9BV23 Membrane; Single-pass type II membrane protein (By similarity). mitochondrion 28 2 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms ABHD8 HGNC:23759 abhydrolase domain containing 8 Q96I13 mitochondrion 82 0 mitochondrion mitochondrion Mammalia Cell.Organisms Cell.Organisms ABI1 HGNC:11320 abl-interactor 1 Q8IZP0 Cytoplasm (By similarity). Nucleus (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes (By similarity). Cytosol (GO:0005829) 9010225,17101133 cytoplasm 42 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ABI2 HGNC:24011 abl-interactor 2 Q9NYB9 Cytoplasm (By similarity). Isoform 1: Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 10995551,10995551,17101133 cytoplasm 45 0 cytoplasm. nucleus multiple Catarrhini Mammalia Eukaryota ABI3 HGNC:29859 ABI family, member 3 Q9P2A4 Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells. Cytoplasm (GO:0005737) 11956071,17101133 cytoplasm 100 0 cytoplasm cytoplasm Theria Theria Eukaryota ABI3BP HGNC:17265 ABI family, member 3 (NESH) binding protein Q7Z7G0 Secreted (Potential). plasma membrane 14 0 n/a n/a Euteleostomi Deuterostomia Bilateria ABL1 HGNC:76 c-abl oncogene 1, non-receptor tyrosine kinase P00519 Cytoplasm, cytoskeleton. Nucleus. Mitochondrion (By similarity). Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Cell projection (GO:0042995); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 17081983,17081983/11509666,11350980,16831423,16888623,11509666,16648821,15696159,16831423,12777393,7565761,12445832,16648821,16888623,7565761,17101133 cytoplasm 47 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms ABL2 HGNC:77 c-abl oncogene 2, non-receptor tyrosine kinase P42684 Cytoplasm, cytoskeleton. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/8700546,2198571 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms ABLIM1 HGNC:78 actin binding LIM protein 1 O14639 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the cytoskeleton (By similarity). Actin cytoskeleton (GO:0015629);Nucleus (GO:0005634) 9245787/17081983 cytoplasm 90 0 nucleus nucleus Bilateria Bilateria Eukaryota ABLIM2 HGNC:19195 actin binding LIM protein family, member 2 Q6H8Q1 Cytoplasm. Note=In skeletal muscle, sarcomeric or cosarcomeric localization (By similarity). Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ABLIM3 HGNC:29132 actin binding LIM protein family, member 3 O94929 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 15337165 cytoplasm 46 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ABO HGNC:79 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) P16442 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. Extracellular (GO:0005576) 4831233 golgi apparatus membrane 36 1 golgi apparatus membrane. secreted multiple Tetrapoda Euteleostomi NA ABR HGNC:81 active BCR-related Q12979 Cytoplasm (GO:0005737) cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota ABRA HGNC:30655 actin-binding Rho activating protein Q8N0Z2 Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines (By similarity). Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 11983702,11983702 cytoplasm 74 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ABRACL HGNC:21230 ABRA C-terminal like Q9P1F3 cytoplasm 23 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota ABT1 HGNC:17369 activator of basal transcription 1 Q9ULW3 Nucleus (By similarity). Nucleus, nucleolus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 10648625,11790298,15635413 nucleus 84 0 nucleus nucleus Eukaryota Eukaryota NA ABTB1 HGNC:18275 ankyrin repeat and BTB (POZ) domain containing 1 Q969K4 Cytoplasm. Cytoplasm (GO:0005737) 11494141 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms ABTB2 HGNC:23842 ankyrin repeat and BTB (POZ) domain containing 2 Q8N961 Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,18459963,,,18459963, mitochondrion 18 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms ACAA1 HGNC:82 acetyl-CoA acyltransferase 1 P09110 Peroxisome. Peroxisome (GO:0005777); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10960480,11418601,10960480,15598749 peroxisome 100 0 cytoplasm. mitochondrion. peroxisome multiple Euteleostomi Cell.Organisms Cell.Organisms ACAA2 HGNC:83 acetyl-CoA acyltransferase 2 P42765 Mitochondrion. Note=Colocalizes with BNIP3 in the mitochondria. Mitochondrion (GO:0005739) 8241273,15033988 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ACACA HGNC:84 acetyl-CoA carboxylase alpha Q13085 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/10677481,7907095 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms ACACB HGNC:85 acetyl-CoA carboxylase beta O00763 Endomembrane system. Note=May associate with membranes. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 10677481,10677481 cytoplasm 71 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms ACAD10 HGNC:21597 acyl-CoA dehydrogenase family, member 10 Q6JQN1 mitochondrion 12 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ACAD11 HGNC:30211 acyl-CoA dehydrogenase family, member 11 Q709F0 Peroxisome (By similarity). Mitochondrion. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. Peroxisome (GO:0005777) 14561759 mitochondrion 11 0 mitochondrion. peroxisome multiple NA NA Cell.Organisms ACAD8 HGNC:87 acyl-CoA dehydrogenase family, member 8 Q9UKU7 Mitochondrion. Mitochondrion (GO:0005739) 11013134,12359132 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms ACAD9 HGNC:21497 acyl-CoA dehydrogenase family, member 9 Q9H845 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 15598749 mitochondrion 23 0 mitochondrion mitochondrion Chordata Cell.Organisms Cell.Organisms ACADL HGNC:88 acyl-CoA dehydrogenase, long chain P28330 Mitochondrion matrix. Mitochondrion (GO:0005739) 9714723 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms ACADM HGNC:89 acyl-CoA dehydrogenase, C-4 to C-12 straight chain P11310 Mitochondrion matrix. Mitochondrion (GO:0005739) 1731887,15033988,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms ACADS HGNC:90 acyl-CoA dehydrogenase, C-2 to C-3 short chain P16219 Mitochondrion matrix. Mitochondrion (GO:0005739) 9383286,15033988,15598749 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ACADSB HGNC:91 acyl-CoA dehydrogenase, short/branched chain P45954 Mitochondrion matrix. Mitochondrion (GO:0005739) 7698750 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ACADVL HGNC:92 acyl-CoA dehydrogenase, very long chain P49748 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 8466512,15033988,15598749 mitochondrion 20 0 mitochondrion mitochondrion Mammalia Cell.Organisms Cell.Organisms ACAN HGNC:319 aggrecan P16112 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8314595,7240256 secreted 35 0 secreted secreted Euteleostomi Bilateria Cell.Organisms ACAP1 HGNC:16467 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Q15027 Cytoplasm (GO:0005737); Endosome (GO:0005768); Mitochondrion (GO:0005739) 11062263,11062263,15598749 cytoplasm 24 0 cytoplasm. endosome. mitochondrion multiple Bilateria Eukaryota Cell.Organisms ACAP2 HGNC:16469 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Q15057 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endosome (GO:0005768) 11062263,11062263,11062263 cytoplasm 32 0 cytoplasm. endosome multiple Bilateria Eukaryota Cell.Organisms ACAP3 HGNC:16754 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Q96P50 nucleus 34 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms ACAT1 HGNC:93 acetyl-CoA acetyltransferase 1 P24752 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 1979337,15561729,9607396 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms ACAT2 HGNC:94 acetyl-CoA acetyltransferase 2 Q9BWD1 Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 7911016,10327276 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Cell.Organisms Cell.Organisms Cell.Organisms ACBD3 HGNC:15453 acyl-CoA binding domain containing 3 Q9H3P7 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Mitochondrion (By similarity). Note=Also mitochondrial (via its interaction with PBR) (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11590181,11590181 secreted 36 0 cytoplasm. golgi apparatus multiple Euteleostomi Bilateria Holozoa ACBD4 HGNC:23337 acyl-CoA binding domain containing 4 Q8NC06 peroxisome membrane 38 0 peroxisome membrane peroxisome membrane Theria Bilateria Cell.Organisms ACBD5 HGNC:23338 acyl-CoA binding domain containing 5 Q5T8D3 Peroxisome membrane; Single-pass membrane protein (By similarity). Nucleus (GO:0005634) 17081983 peroxisome membrane 79 1 nucleus nucleus Chordata Eukaryota Cell.Organisms ACBD6 HGNC:23339 acyl-CoA binding domain containing 6 Q9BR61 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms ACBD7 HGNC:17715 acyl-CoA binding domain containing 7 Q8N6N7 cytoplasm 28 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms ACCS HGNC:23989 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) Q96QU6 mitochondrion 7 0 mitochondrion mitochondrion Amniota Eukaryota Cell.Organisms ACCSL HGNC:34391 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like Q4AC99 cytoplasm 8 0 cytoplasm cytoplasm Euarchontoglires Eukaryota Cell.Organisms ACD HGNC:25070 adrenocortical dysplasia homolog (mouse) Q96AP0 Nucleus. Chromosome, telomere. Nucleus (GO:0005634) 15181449,15231715 nucleus 100 0 nucleus nucleus Theria Tetrapoda Euteleostomi ACE HGNC:2707 angiotensin I converting enzyme P12821 Angiotensin-converting enzyme, soluble form: Secreted. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7977726 secreted 79 1 plasma membrane. secreted multiple Bilateria Cell.Organisms Cell.Organisms ACE2 HGNC:13557 angiotensin I converting enzyme 2 Q9BYF1 Processed angiotensin-converting enzyme 2: Secreted. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12025971,11815627 secreted 22 0 plasma membrane. secreted multiple Amniota Deuterostomia Cell.Organisms ACER1 HGNC:18356 alkaline ceramidase 1 Q8TDN7 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 12783875 endoplasmic reticulum membrane 74 7 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Eukaryota ACER2 HGNC:23675 alkaline ceramidase 2 Q5QJU3 Golgi apparatus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 100 7 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms ACER3 HGNC:16066 alkaline ceramidase 3 Q9NUN7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11356846,11356846 golgi apparatus membrane 12 7 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Tetrapoda Eukaryota NA ACHE HGNC:108 acetylcholinesterase (Yt blood group) P22303 Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Isoform T: Nucleus. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576); Integral to membrane (GO:0016021) 8488842,1609795,3319614 secreted 42 0 nucleus. secreted multiple Bilateria Cell.Organisms Cell.Organisms ACIN1 HGNC:17066 apoptotic chromatin condensation inducer 1 Q9UKV3 Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10490026,17081983,10490026/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota ACKR2 HGNC:1565 atypical chemokine receptor 2 O00590 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12671049 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Amniota Eumetazoa ACKR3 HGNC:23692 atypical chemokine receptor 3 P25106 Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Early endosome. Recycling endosome (By similarity). Note=Localized mainly in perinuclear regions in neurons and in early endosomes in T-lymphocytes and some other cell types, with very low levels detected on the cell surface. May spontaneously cycle between the plasma membrane and endosomal compartments. Plasma membrane (GO:0005886) 8198609 plasma membrane 14 7 cytoplasm. endosome. plasma membrane multiple Euteleostomi Euteleostomi Metazoa ACKR4 HGNC:1611 atypical chemokine receptor 4 Q9NPB9 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa ACLY HGNC:115 ATP citrate lyase P53396 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 3305493,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Opisthokonta Cell.Organisms NA ACMSD HGNC:19288 aminocarboxymuconate semialdehyde decarboxylase Q8TDX5 Cytoplasm (GO:0005737) 12140278 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms ACN9 HGNC:21752 ACN9 homolog (S. cerevisiae) Q9NRP4 Mitochondrion (Potential). mitochondrion 22 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota ACO1 HGNC:117 aconitase 1, soluble P21399 Cytoplasm. Cytoplasm (GO:0005737); Golgi membrane (GO:0000139); Endoplasmic reticulum membrane (GO:0005789) 10419470,16144863,16144863 cytoplasm 100 0 cytoplasm. endoplasmic reticulum membrane. golgi apparatus membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ACO2 HGNC:118 aconitase 2, mitochondrial Q99798 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 9630632,15598749 mitochondrion 96 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms ACOT1 HGNC:33128 acyl-CoA thioesterase 1 Q86TX2 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms ACOT11 HGNC:18156 acyl-CoA thioesterase 11 Q8WXI4 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms ACOT12 HGNC:24436 acyl-CoA thioesterase 12 Q8WYK0 Cytoplasm. Cytoplasm (GO:0005737) 11322891,12767336 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms ACOT13 HGNC:20999 acyl-CoA thioesterase 13 Q9NPJ3 Cytoplasm (By similarity). Mitochondrion (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms ACOT2 HGNC:18431 acyl-CoA thioesterase 2 P49753 Mitochondrion. Peroxisome (GO:0005777) 10944470 mitochondrion 100 0 mitochondrion. peroxisome multiple Euteleostomi Bilateria Cell.Organisms ACOT4 HGNC:19748 acyl-CoA thioesterase 4 Q8N9L9 Peroxisome. Peroxisome (GO:0005777) 10567408 peroxisome 100 0 peroxisome peroxisome Eutheria Eutheria Cell.Organisms ACOT6 HGNC:33159 acyl-CoA thioesterase 6 Q3I5F7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Human Human Cell.Organisms ACOT7 HGNC:24157 acyl-CoA thioesterase 7 O00154 Isoform 4: Cytoplasm. Isoform 6: Cytoplasm. Isoform 1: Mitochondrion. Isoform 5: Mitochondrion. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739);Cytosol (GO:0005829);Nucleus (GO:0005634); Mitochondrion (GO:0005739);Cytosol (GO:0005829); Nucleus (GO:0005634) 10578051,12435388,12435388,12435388/12435388/12435388,12435388/12435388,12435388 cytoplasm 86 0 cytoplasm. mitochondrion. nucleus multiple Chordata Cell.Organisms Cell.Organisms ACOT8 HGNC:15919 acyl-CoA thioesterase 8 O14734 Peroxisome. Cytoplasm (GO:0005737); Peroxisomal matrix (GO:0005782) 10944470,10092594,10092594 peroxisome 100 0 cytoplasm. peroxisome multiple Euteleostomi Cell.Organisms Cell.Organisms ACOT9 HGNC:17152 acyl-CoA thioesterase 9 Q9Y305 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 10383425,15561729 cytoplasm 8 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms ACOX1 HGNC:119 acyl-CoA oxidase 1, palmitoyl Q15067 Peroxisome. Nucleus (GO:0005634);Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 17081983/10960480,8040306,15598749 peroxisome 100 0 mitochondrion. nucleus. peroxisome multiple Bilateria Eukaryota Cell.Organisms ACOX2 HGNC:120 acyl-CoA oxidase 2, branched chain Q99424 Peroxisome. Peroxisome (GO:0005777) 8943006 peroxisome 100 0 peroxisome peroxisome Tetrapoda Chordata Cell.Organisms ACOX3 HGNC:121 acyl-CoA oxidase 3, pristanoyl O15254 Peroxisome (Potential). Peroxisome (GO:0005777) 9271077 peroxisome 68 0 peroxisome peroxisome Bilateria Cell.Organisms Cell.Organisms ACOXL HGNC:25621 acyl-CoA oxidase-like Q9NUZ1 peroxisome 22 2 peroxisome peroxisome Mammalia Euteleostomi Cell.Organisms ACP1 HGNC:122 acid phosphatase 1, soluble P24666 Cytoplasm. Cytoplasm (GO:0005737) 1587862,1304913 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms ACP2 HGNC:123 acid phosphatase 2, lysosomal P11117 Lysosome membrane; Single-pass membrane protein; Lumenal side. Lysosome lumen. Note=The soluble form arises by proteolytic processing of the membrane-bound form. Lysosome (GO:0005764); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 11801736,11801736,11801736,11801736 secreted 15 1 endosome. golgi apparatus. lysosome. lysosome membrane. plasma membrane multiple Bilateria Eukaryota Cell.Organisms ACP5 HGNC:124 acid phosphatase 5, tartrate resistant P13686 Lysosome. Lysosome (GO:0005764); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12450668,12450668,12450668 secreted 82 0 cytoplasm. lysosome. secreted multiple Deuterostomia Cell.Organisms Cell.Organisms ACP6 HGNC:29609 acid phosphatase 6, lysophosphatidic Q9NPH0 Secreted (Probable). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10506173,12010880 mitochondrion 15 0 cytoplasm. mitochondrion. secreted multiple Deuterostomia Eukaryota Cell.Organisms ACPP HGNC:125 acid phosphatase, prostate P15309 Isoform 1: Secreted. Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Lysosome (GO:0005764); Nucleus (GO:0005634) 12525165,10477906,7923807,9187691,2411954,11547122 secreted 14 0 cytoplasm. lysosome. lysosome membrane. nucleus. plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms ACPT HGNC:14376 acid phosphatase, testicular Q9BZG2 Membrane; Single-pass type I membrane protein (Potential). secreted 13 1 secreted secreted Eutheria Euteleostomi Cell.Organisms ACR HGNC:126 acrosin P10323 endoplasmic reticulum membrane 26 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Cell.Organisms ACRBP HGNC:17195 acrosin binding protein Q8NEB7 Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=Colocalizes with proacrosin in the acrosome of sperm (By similarity). nucleus 35 0 nucleus nucleus Theria Theria Tetrapoda ACRC HGNC:15805 acidic repeat containing Q96QF7 Nucleus (Potential). Nucleus (GO:0005634) 11714101 mitochondrion 29 0 nucleus nucleus Catarrhini Eukaryota Eukaryota ACRV1 HGNC:127 acrosomal vesicle protein 1 P26436 Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Nascent acrosomal vesicle of Golgi phase spermatids. Golgi apparatus (GO:0005794); Lysosome (GO:0005764) 2298314,8288254,11730901 nucleus 24 0 golgi apparatus. lysosome multiple Eutheria Mammalia Cell.Organisms ACSBG1 HGNC:29567 acyl-CoA synthetase bubblegum family member 1 Q96GR2 Cytoplasm. Cytoplasmic vesicle (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity). Cytoplasm (GO:0005737); Microsome (GO:0005792); Mitochondrion (GO:0005739) 10954726,14516277,12975357 endoplasmic reticulum 11 0 cytoplasm. mitochondrion multiple Euteleostomi Cell.Organisms Cell.Organisms ACSBG2 HGNC:24174 acyl-CoA synthetase bubblegum family member 2 Q5FVE4 Cytoplasm. Membrane; Peripheral membrane protein. endoplasmic reticulum 9 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms ACSF2 HGNC:26101 acyl-CoA synthetase family member 2 Q96CM8 Mitochondrion (Potential). mitochondrion 10 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ACSF3 HGNC:27288 acyl-CoA synthetase family member 3 Q4G176 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms ACSL1 HGNC:3569 acyl-CoA synthetase long-chain family member 1 P33121 Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Peroxisome (GO:0005777) 2973813,1599407,2007410,7948012,1599407,8399326,1599407,2007410 peroxisome 26 0 endoplasmic reticulum. mitochondrion. peroxisome multiple Eukaryota Cell.Organisms Cell.Organisms ACSL3 HGNC:3570 acyl-CoA synthetase long-chain family member 3 O95573 Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). Mitochondrion (GO:0005739); Peroxisome (GO:0005777) 6240978,15561729,6240978 mitochondrion 34 0 mitochondrion. peroxisome multiple Opisthokonta Eukaryota Cell.Organisms ACSL4 HGNC:3571 acyl-CoA synthetase long-chain family member 4 O60488 Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). Microsome (GO:0005792); Mitochondrion (GO:0005739) 10874125,1567471,15561729 mitochondrion 33 1 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms ACSL5 HGNC:16526 acyl-CoA synthetase long-chain family member 5 Q9ULC5 Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single- pass type III membrane protein (By similarity). Mitochondrion (GO:0005739) 12147264,11319232 peroxisome 31 0 endoplasmic reticulum. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms ACSL6 HGNC:16496 acyl-CoA synthetase long-chain family member 6 Q9UKU0 Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). Plasma membrane (GO:0005886) 10548543 peroxisome 30 0 peroxisome peroxisome Eukaryota Cell.Organisms Cell.Organisms ACSM1 HGNC:18049 acyl-CoA synthetase medium-chain family member 1 Q08AH1 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 11470804 mitochondrion 70 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ACSM2A HGNC:32017 acyl-CoA synthetase medium-chain family member 2A Q08AH3 Mitochondrion matrix (By similarity). mitochondrion 96 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ACSM2B HGNC:30931 acyl-CoA synthetase medium-chain family member 2B Q68CK6 Mitochondrion matrix. Mitochondrion (GO:0005739) 12616642,11415461,15122652,10434065,8884467,8934636 mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ACSM3 HGNC:10522 acyl-CoA synthetase medium-chain family member 3 Q53FZ2 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 11772874,11470804 mitochondrion 83 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ACSM4 HGNC:32016 acyl-CoA synthetase medium-chain family member 4 P0C7M7 Mitochondrion matrix (By similarity). mitochondrion 83 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ACSM5 HGNC:26060 acyl-CoA synthetase medium-chain family member 5 Q6NUN0 Mitochondrion matrix (By similarity). mitochondrion 52 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ACSS1 HGNC:16091 acyl-CoA synthetase short-chain family member 1 Q9NUB1 Mitochondrion matrix. mitochondrion 100 1 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ACSS2 HGNC:15814 acyl-CoA synthetase short-chain family member 2 Q9NR19 Cytoplasm. Cytoplasm (GO:0005737) 10843999 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ACSS3 HGNC:24723 acyl-CoA synthetase short-chain family member 3 Q9H6R3 Mitochondrion (Potential). cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms ACTA1 HGNC:129 actin, alpha 1, skeletal muscle P68133 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Kinetochore (GO:0000776); Extracellular (GO:0005576) 10508519,11780067,16188874 cytoplasm 100 0 cytoplasm. secreted multiple Eukaryota Eukaryota Eukaryota ACTA2 HGNC:130 actin, alpha 2, smooth muscle, aorta P62736 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 8138584,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Eukaryota ACTB HGNC:132 actin, beta P60709 Cytoplasm, cytoskeleton. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Cytosol (GO:0005829); Extracellular (GO:0005576); Cytoskeleton (GO:0005856); Mitochondrion (GO:0005739) 11257002,10677499,11950601,11790298,16514417,16892067,16188874,15561729,15598749 cytoplasm 100 0 cytoplasm. golgi apparatus. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota ACTBL2 HGNC:17780 actin, beta-like 2 Q562R1 Cytoplasm, cytoskeleton (By similarity). cytoplasm 90 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ACTC1 HGNC:143 actin, alpha, cardiac muscle 1 P68032 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11936879,12445881,10847344 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ACTG1 HGNC:144 actin, gamma 1 P63261 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Cytosol (GO:0005829) 3335520,16263121 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota NA ACTG2 HGNC:145 actin, gamma 2, smooth muscle, enteric P63267 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 10655297 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ACTL10 HGNC:16127 actin-like 10 Q5JWF8 cytoplasm 20 0 cytoplasm cytoplasm Theria Theria Eukaryota ACTL6A HGNC:24124 actin-like 6A O96019 Nucleus. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634);Cytoplasm (GO:0005737); Chromosome (GO:0005694); Kinetochore (GO:0000776); Nucleus (GO:0005634) 17081983/12353638,12353638/14503849,16230350,11780067,14503849,11266125,9845365,11839798,10380635,19059367 cytoplasm 27 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota ACTL6B HGNC:160 actin-like 6B O94805 Nucleus. Nucleus (GO:0005634) 12565893 cytoplasm 28 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ACTL7A HGNC:161 actin-like 7A Q9Y615 Cytoplasm, cytoskeleton (By similarity). Golgi apparatus (By similarity). Cytoplasm (By similarity). Nucleus (By similarity). Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail (By similarity). Cytoskeleton (GO:0005856) 10373328 cytoplasm 31 0 cytoplasm cytoplasm Theria Theria Eukaryota ACTL7B HGNC:162 actin-like 7B Q9Y614 Cytoplasm, cytoskeleton (By similarity). Cytoskeleton (GO:0005856) 10373328 cytoplasm 32 0 cytoplasm cytoplasm Theria Theria Eukaryota ACTL8 HGNC:24018 actin-like 8 Q9H568 Cytoplasm, cytoskeleton (By similarity). cytoplasm 19 0 cytoplasm cytoplasm Catarrhini Eutheria Eukaryota ACTL9 HGNC:28494 actin-like 9 Q8TC94 Cytoplasm, cytoskeleton (By similarity). cytoplasm 28 0 cytoplasm cytoplasm Theria Theria NA ACTN1 HGNC:163 actinin, alpha 1 P12814 Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane (By similarity). Cell projection, ruffle (By similarity). Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity). Cytoplasm (GO:0005737); Mitochondrial membrane (GO:0005740); Cytosol (GO:0005829); Cytoskeleton (GO:0005856); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 9599291,15147863,16263121,15561729,15598749,17081983 cytoplasm 76 0 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Opisthokonta Eukaryota Cell.Organisms ACTN2 HGNC:164 actinin, alpha 2 P35609 Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle. Cytoplasm (GO:0005737); Mitochondrial membrane (GO:0005740); Actin filament (GO:0005884) 11440986,15147863,15147863 cytoplasm 100 0 cytoplasm. mitochondrion membrane multiple Opisthokonta Eukaryota Cell.Organisms ACTN3 HGNC:165 actinin, alpha 3 (gene/pseudogene) Q08043 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 11440986,16188874 cytoplasm 76 0 cytoplasm. secreted multiple NA NA Cell.Organisms ACTN4 HGNC:166 actinin, alpha 4 O43707 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC- 2, and bladder cancer KU-7). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 10656685,16944923,10656685,16944923,15598749 cytoplasm 74 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Cell.Organisms ACTR10 HGNC:17372 actin-related protein 10 homolog (S. cerevisiae) Q9NZ32 Cytoplasm, cytoskeleton (By similarity). Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737) ,17081983 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ACTR1A HGNC:167 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) P61163 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Centrosome (GO:0005813) 1356230,1356230,15561729 cytoplasm 43 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ACTR1B HGNC:168 ARP1 actin-related protein 1 homolog B, centractin beta (yeast) P42025 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737) cytoplasm 44 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ACTR2 HGNC:169 ARP2 actin-related protein 2 homolog (yeast) P61160 Cytoplasm, cytoskeleton. Cell projection. Cytoplasm (GO:0005737); Actin cytoskeleton (GO:0015629) 9359840,9230079,12468383,9359840,9230079,11706047 cytoplasm 36 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ACTR3 HGNC:170 ARP3 actin-related protein 3 homolog (yeast) P61158 Cytoplasm, cytoskeleton. Cell projection. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9230079,15635413,11790298 cytoplasm 27 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ACTR3B HGNC:17256 ARP3 actin-related protein 3 homolog B (yeast) Q9P1U1 Cytoplasm, cytoskeleton (By similarity). Cell projection (By similarity). Cytoskeleton (GO:0005856) 10806390 cytoplasm 25 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ACTR3C HGNC:37282 ARP3 actin-related protein 3 homolog C (yeast) Q9C0K3 cytoplasm 26 0 cytoplasm cytoplasm Human Human Eukaryota ACTR5 HGNC:14671 ARP5 actin-related protein 5 homolog (yeast) Q9H9F9 Nucleus. Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling. Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses. Chromosome (GO:0005694) 16230350 cytoplasm 7 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota ACTR6 HGNC:24025 ARP6 actin-related protein 6 homolog (yeast) Q9GZN1 Cytoplasm, cytoskeleton (By similarity). Cytoskeleton (GO:0005856) cytoplasm 13 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ACTR8 HGNC:14672 ARP8 actin-related protein 8 homolog (yeast) Q9H981 Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Chromosome (GO:0005694); Nucleus (GO:0005634) 16230350,17081983 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ACTRT1 HGNC:24027 actin-related protein T1 Q8TDG2 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) cytoplasm 36 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota ACTRT2 HGNC:24026 actin-related protein T2 Q8TDY3 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 11750065,11750065 cytoplasm 37 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota ACTRT3 HGNC:24022 actin-related protein T3 Q9BYD9 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 38 0 cytoplasm cytoplasm NA NA Eukaryota ACVR1 HGNC:171 activin A receptor, type I Q04771 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8622651,12032389 plasma membrane 13 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ACVR1B HGNC:172 activin A receptor, type IB P36896 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 10652306,12665502 plasma membrane 16 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ACVR1C HGNC:18123 activin A receptor, type IC Q8NER5 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12063393 plasma membrane 15 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ACVR2A HGNC:173 activin A receptor, type IIA P27037 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8622651,12032389 plasma membrane 26 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ACVR2B HGNC:174 activin A receptor, type IIB Q13705 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 12493773 plasma membrane 24 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ACVRL1 HGNC:175 activin A receptor type II-like 1 P37023 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9651680 plasma membrane 15 1 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms ACY1 HGNC:177 aminoacylase 1 Q03154 Cytoplasm. Cytoplasm (GO:0005737) 8394326 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms ACY3 HGNC:24104 aspartoacylase (aminocyclase) 3 Q96HD9 Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 14656720,14656720 cytoplasm 39 0 cytoplasm cytoplasm Euarchontoglires Chordata Cell.Organisms ACYP1 HGNC:179 acylphosphatase 1, erythrocyte (common) type P07311 Cytoplasm (GO:0005737) 7796909,1645713 mitochondrion 13 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ACYP2 HGNC:180 acylphosphatase 2, muscle type P14621 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9070879,9070879 mitochondrion 14 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ADA HGNC:186 adenosine deaminase P00813 Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen (By similarity). Cytoplasm (By similarity). Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1856451,2770711 secreted 13 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms ADAD1 HGNC:30713 adenosine deaminase domain containing 1 (testis-specific) Q96M93 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 86 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ADAD2 HGNC:30714 adenosine deaminase domain containing 2 Q8NCV1 Nucleus (GO:0005634) nucleus 20 0 nucleus nucleus Mammalia Euteleostomi Metazoa ADAL HGNC:31853 adenosine deaminase-like Q6DHV7 secreted 12 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms ADAM10 HGNC:188 ADAM metallopeptidase domain 10 O14672 Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 10423016,10423016,10423016 secreted 34 1 endomembrane system. golgi apparatus. nucleus. plasma membrane multiple Bilateria Bilateria Eukaryota ADAM11 HGNC:189 ADAM metallopeptidase domain 11 O75078 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7956356 secreted 37 1 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota ADAM12 HGNC:190 ADAM metallopeptidase domain 12 O43184 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted (Potential). Isoform 4: Secreted (Potential). Extracellular (GO:0005576);Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471);Plasma membrane (GO:0005886) 9417060/10964655,10964655/9417060 secreted 42 1 cytoplasm. golgi apparatus. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms ADAM15 HGNC:193 ADAM metallopeptidase domain 15 Q13444 Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). Plasma membrane (GO:0005886) 8617717,12243749 secreted 42 1 endomembrane system. plasma membrane multiple Theria Bilateria Eukaryota ADAM17 HGNC:195 ADAM metallopeptidase domain 17 P78536 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Nucleus (GO:0005634) 11733179,17255933,17081983 secreted 27 1 nucleus. plasma membrane multiple Bilateria Bilateria Eukaryota ADAM18 HGNC:196 ADAM metallopeptidase domain 18 Q9Y3Q7 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12200459 secreted 33 1 plasma membrane plasma membrane Theria Amniota Eukaryota ADAM19 HGNC:197 ADAM metallopeptidase domain 19 Q9H013 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12006600,12006600,12006600 secreted 47 1 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Bilateria Eukaryota ADAM2 HGNC:198 ADAM metallopeptidase domain 2 Q99965 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8702389 secreted 44 1 plasma membrane plasma membrane Mammalia Mammalia Eukaryota ADAM20 HGNC:199 ADAM metallopeptidase domain 20 O43506 Membrane; Single-pass type I membrane protein. secreted 35 1 secreted secreted Amniota Amniota Cell.Organisms ADAM21 HGNC:200 ADAM metallopeptidase domain 21 Q9UKJ8 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10524237 secreted 35 1 plasma membrane plasma membrane Amniota Amniota Eukaryota ADAM22 HGNC:201 ADAM metallopeptidase domain 22 Q9P0K1 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10524237 secreted 39 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms ADAM23 HGNC:202 ADAM metallopeptidase domain 23 O75077 Cell membrane; Single-pass type I membrane protein (Potential). Isoform Gamma: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10749942,9693107,10506182 secreted 35 1 plasma membrane. secreted multiple Euteleostomi Bilateria Eukaryota ADAM28 HGNC:206 ADAM metallopeptidase domain 28 Q9UKQ2 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886) 11724793,9288739 secreted 42 1 plasma membrane. secreted multiple Amniota Euteleostomi Cell.Organisms ADAM29 HGNC:207 ADAM metallopeptidase domain 29 Q9UKF5 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10512762 secreted 31 1 plasma membrane plasma membrane Amniota Amniota Eukaryota ADAM30 HGNC:208 ADAM metallopeptidase domain 30 Q9UKF2 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10512762 secreted 35 1 plasma membrane plasma membrane Mammalia Mammalia Eukaryota ADAM32 HGNC:15479 ADAM metallopeptidase domain 32 Q8TC27 Membrane; Single-pass type I membrane protein (Potential). Nucleus (GO:0005634) 17081983 secreted 28 1 nucleus nucleus Mammalia Mammalia Eukaryota ADAM33 HGNC:15478 ADAM metallopeptidase domain 33 Q9BZ11 Membrane; Single-pass type I membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/11814695 secreted 44 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Eukaryota ADAM7 HGNC:214 ADAM metallopeptidase domain 7 Q9H2U9 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11514362 secreted 44 1 plasma membrane plasma membrane Mammalia Mammalia Eukaryota ADAM8 HGNC:215 ADAM metallopeptidase domain 8 P78325 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9126482 secreted 35 1 plasma membrane plasma membrane Theria Bilateria Eukaryota ADAM9 HGNC:216 ADAM metallopeptidase domain 9 Q13443 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/8647900 secreted 40 1 cytoplasm. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms ADAMDEC1 HGNC:16299 ADAM-like, decysin 1 O15204 Secreted (By similarity). Extracellular (GO:0005576) 11673514 secreted 57 0 secreted secreted Mammalia Chordata Eukaryota ADAMTS1 HGNC:217 ADAM metallopeptidase with thrombospondin type 1 motif, 1 Q9UHI8 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 9593739,10373500,12054629,9593739,12907688 secreted 78 0 golgi apparatus. secreted multiple Bilateria Bilateria Eukaryota ADAMTS10 HGNC:13201 ADAM metallopeptidase with thrombospondin type 1 motif, 10 Q9H324 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 15355968 secreted 100 0 secreted secreted Deuterostomia Bilateria NA ADAMTS12 HGNC:14605 ADAM metallopeptidase with thrombospondin type 1 motif, 12 P58397 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576); Nucleus (GO:0005634) 11167130,17081983 secreted 35 0 nucleus. secreted multiple Deuterostomia Bilateria Eukaryota ADAMTS13 HGNC:1366 ADAM metallopeptidase with thrombospondin type 1 motif, 13 Q76LX8 Secreted. Note=Secretion enhanced by O- fucosylation of TSP type-1 repeats. Extracellular (GO:0005576) 11167130 secreted 100 0 secreted secreted Tetrapoda Euteleostomi NA ADAMTS14 HGNC:14899 ADAM metallopeptidase with thrombospondin type 1 motif, 14 Q8WXS8 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11779638 secreted 32 0 secreted secreted Euteleostomi Euteleostomi Eukaryota ADAMTS15 HGNC:16305 ADAM metallopeptidase with thrombospondin type 1 motif, 15 Q8TE58 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) secreted 39 0 secreted secreted Bilateria Bilateria Eukaryota ADAMTS16 HGNC:17108 ADAM metallopeptidase with thrombospondin type 1 motif, 16 Q8TE57 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) plasma membrane 38 0 n/a n/a Deuterostomia Bilateria Eukaryota ADAMTS17 HGNC:17109 ADAM metallopeptidase with thrombospondin type 1 motif, 17 Q8TE56 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) secreted 26 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms ADAMTS18 HGNC:17110 ADAM metallopeptidase with thrombospondin type 1 motif, 18 Q8TE60 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11867212 secreted 36 0 secreted secreted Deuterostomia Bilateria Eukaryota ADAMTS19 HGNC:17111 ADAM metallopeptidase with thrombospondin type 1 motif, 19 Q8TE59 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) secreted 22 0 secreted secreted Tetrapoda Tetrapoda Eukaryota ADAMTS2 HGNC:218 ADAM metallopeptidase with thrombospondin type 1 motif, 2 O95450 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11167130 secreted 32 0 secreted secreted Euteleostomi Euteleostomi Eukaryota ADAMTS20 HGNC:17178 ADAM metallopeptidase with thrombospondin type 1 motif, 20 P59510 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 12562771,12514189 secreted 36 0 secreted secreted Bilateria Bilateria Eukaryota ADAMTS3 HGNC:219 ADAM metallopeptidase with thrombospondin type 1 motif, 3 O15072 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11167130 secreted 32 0 secreted secreted Euteleostomi Euteleostomi Eukaryota ADAMTS4 HGNC:220 ADAM metallopeptidase with thrombospondin type 1 motif, 4 O75173 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11167130 secreted 41 0 secreted secreted Bilateria Bilateria Metazoa ADAMTS5 HGNC:221 ADAM metallopeptidase with thrombospondin type 1 motif, 5 Q9UNA0 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10464288,11167130 secreted 32 0 secreted secreted Bilateria Bilateria Metazoa ADAMTS6 HGNC:222 ADAM metallopeptidase with thrombospondin type 1 motif, 6 Q9UKP5 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11167130 secreted 51 0 secreted secreted Deuterostomia Bilateria Eukaryota ADAMTS7 HGNC:223 ADAM metallopeptidase with thrombospondin type 1 motif, 7 Q9UKP4 Secreted, extracellular space, extracellular matrix (By similarity). Note=Also found associated with the external cell surface (By similarity). Extracellular (GO:0005576) 10464288,11167130 secreted 67 0 secreted secreted Deuterostomia Bilateria Holozoa ADAMTS8 HGNC:224 ADAM metallopeptidase with thrombospondin type 1 motif, 8 Q9UP79 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10438512 secreted 41 0 secreted secreted Bilateria Bilateria Metazoa ADAMTS9 HGNC:13202 ADAM metallopeptidase with thrombospondin type 1 motif, 9 Q9P2N4 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11167130 secreted 39 0 secreted secreted Bilateria Bilateria Eukaryota ADAMTSL1 HGNC:14632 ADAMTS-like 1 Q8N6G6 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11805097,14667842 secreted 100 0 secreted secreted Chordata Chordata Eukaryota ADAMTSL2 HGNC:14631 ADAMTS-like 2 Q86TH1 Secreted (Potential). secreted 22 0 secreted secreted Tetrapoda Euteleostomi Eukaryota ADAMTSL3 HGNC:14633 ADAMTS-like 3 P82987 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 14667842 secreted 100 0 secreted secreted Chordata Chordata Eukaryota ADAMTSL4 HGNC:19706 ADAMTS-like 4 Q6UY14 Secreted, extracellular space, extracellular matrix. Note=Colocalizes with FMN1 microfibrils in the eye ECM. Lysosome (GO:0005764) 16364318 secreted 100 0 lysosome. secreted multiple Deuterostomia Eukaryota Eukaryota ADAMTSL5 HGNC:27912 ADAMTS-like 5 Q6ZMM2 Secreted (Potential). Extracellular (GO:0005576) secreted 28 0 secreted secreted Chordata Chordata Metazoa ADAP1 HGNC:16486 ArfGAP with dual PH domains 1 O75689 Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12565890,15106847,11869802,10448098,11869802,10333475,10448098,11869802,10333475 cytoplasm 29 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota ADAP2 HGNC:16487 ArfGAP with dual PH domains 2 Q9NPF8 Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14690521,14690521 cytoplasm 26 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota ADAR HGNC:225 adenosine deaminase, RNA-specific P55265 Isoform 1: Cytoplasm. Nucleus. Isoform 5: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO1 can mediate its nuclear export. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 7565688,11451992,12954622,11604520,14711814,12429827,12665561,12954622,14711814,15635413,7972084,7565688,7862132,12453429,11451992,12665561,12954622,11604520,14711814,12429827,15561729 nucleus 24 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota ADARB1 HGNC:226 adenosine deaminase, RNA-specific, B1 P78563 Nucleus. Nucleus, nucleolus. Note=Shuttles between nucleoli and the nucleoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9113993,14612560 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ADARB2 HGNC:227 adenosine deaminase, RNA-specific, B2 (non-functional) Q9NS39 Nucleus. Nucleolus (GO:0005730) 15635413 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ADAT1 HGNC:228 adenosine deaminase, tRNA-specific 1 Q9BUB4 nucleus 19 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ADAT2 HGNC:21172 adenosine deaminase, tRNA-specific 2 Q7Z6V5 mitochondrion 22 0 mitochondrion mitochondrion Human Cell.Organisms Cell.Organisms ADAT3 HGNC:25151 adenosine deaminase, tRNA-specific 3 Q96EY9 cytoplasm 28 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ADC HGNC:29957 arginine decarboxylase Q96A70 Integral to membrane (GO:0016021) 14738999 mitochondrion 83 0 mitochondrion mitochondrion Human Amniota Cell.Organisms ADCK1 HGNC:19038 aarF domain containing kinase 1 Q86TW2 Secreted (Potential). mitochondrion 13 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ADCK2 HGNC:19039 aarF domain containing kinase 2 Q7Z695 Membrane; Single-pass membrane protein (Potential). mitochondrion 22 1 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms ADCK3 HGNC:16812 aarF domain containing kinase 3 Q8NI60 Mitochondrion. Mitochondrion (GO:0005739) 11888884 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ADCK4 HGNC:19041 aarF domain containing kinase 4 Q96D53 Membrane; Single-pass membrane protein (Potential). mitochondrion 50 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ADCK5 HGNC:21738 aarF domain containing kinase 5 Q3MIX3 Membrane; Single-pass membrane protein (Potential). mitochondrion 16 3 mitochondrion mitochondrion Eutheria Cell.Organisms NA ADCY1 HGNC:232 adenylate cyclase 1 (brain) Q08828 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11549699 cytoplasm 14 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms ADCY10 HGNC:21285 adenylate cyclase 10 (soluble) Q96PN6 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 9874775,12475901,12475901 cytoplasm 60 5 cytoplasm. mitochondrion. nucleus multiple Amniota Cell.Organisms Cell.Organisms ADCY2 HGNC:233 adenylate cyclase 2 (brain) Q08462 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11549699,11549699 cytoplasm 15 12 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms ADCY3 HGNC:234 adenylate cyclase 3 O60266 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11549699,11549699 cytoplasm 15 12 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms ADCY4 HGNC:235 adenylate cyclase 4 Q8NFM4 Membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11549699,11549699 cytoplasm 21 12 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms ADCY5 HGNC:236 adenylate cyclase 5 O95622 Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1379717,11549699,11549699 cytoplasm 15 13 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms ADCY6 HGNC:237 adenylate cyclase 6 O43306 Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11549699,11549699 cytoplasm 16 12 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms ADCY7 HGNC:238 adenylate cyclase 7 P51828 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9034014 cytoplasm 15 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms ADCY8 HGNC:239 adenylate cyclase 8 (brain) P40145 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11457491 cytoplasm 18 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms ADCY9 HGNC:240 adenylate cyclase 9 O60503 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9628827 cytoplasm 15 12 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ADCYAP1 HGNC:241 adenylate cyclase activating polypeptide 1 (pituitary) P18509 Secreted. Cytoplasmic vesicle (GO:0016023); Extracellular (GO:0005576) 12686458,12504599 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria ADCYAP1R1 HGNC:242 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I P41586 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11959368 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa ADD1 HGNC:243 adducin 1 (alpha) P35611 Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 17081983,17081983/16289097,17081983,15598749,17081983 cytoplasm 18 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms ADD2 HGNC:244 adducin 2 (beta) P35612 Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus (GO:0005634); Cytosol (GO:0005829); Cell junction (GO:0030054); Endocytic vesicle (GO:0030139); Centriole (GO:0005814); Chromosome (GO:0005694); Cytoplasm (GO:0005737) 16116087,17081983,16116087,16116087,16116087,16116087,16116087,17081983 nucleus 10 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms NA ADD3 HGNC:245 adducin 3 (gamma) Q9UEY8 Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/2503523 nucleus 84 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms ADGB HGNC:21212 androglobin Q8N7X0 nucleus 22 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ADH1A HGNC:249 alcohol dehydrogenase 1A (class I), alpha polypeptide P07327 Cytoplasm. Cytoplasm (GO:0005737) 12392591 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ADH1B HGNC:250 alcohol dehydrogenase 1B (class I), beta polypeptide P00325 Cytoplasm. Mitochondrion (GO:0005739) 11398342 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms ADH1C HGNC:251 alcohol dehydrogenase 1C (class I), gamma polypeptide P00326 Cytoplasm. Cytoplasm (GO:0005737) 10405330 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms ADH4 HGNC:252 alcohol dehydrogenase 4 (class II), pi polypeptide P08319 Cytoplasm. Cytoplasm (GO:0005737) 11279029 cytoplasm 100 0 cytoplasm cytoplasm Euarchontoglires Eutheria Cell.Organisms ADH5 HGNC:253 alcohol dehydrogenase 5 (class III), chi polypeptide P11766 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10661511,1453005 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ADH6 HGNC:255 alcohol dehydrogenase 6 (class V) P28332 Cytoplasm. Cytoplasm (GO:0005737) 2198032 cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Eutheria Cell.Organisms ADH7 HGNC:256 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide P40394 Cytoplasm. Cytoplasm (GO:0005737) 8195208 cytoplasm 100 0 cytoplasm cytoplasm Theria Tetrapoda Cell.Organisms ADHFE1 HGNC:16354 alcohol dehydrogenase, iron containing, 1 Q8IWW8 Mitochondrion (By similarity). mitochondrion 87 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ADI1 HGNC:30576 acireductone dioxygenase 1 Q9BV57 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14718544,14718544,14718544 cytoplasm 14 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ADIG HGNC:28606 adipogenin Q0VDE8 Membrane; Single-pass membrane protein (Potential). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15567149,15567149 secreted 46 1 cytoplasm. nucleus multiple Human Eutheria Eutheria ADIPOQ HGNC:13633 adiponectin, C1Q and collagen domain containing Q15848 Secreted. Extracellular (GO:0005576) 11162643 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms ADIPOR1 HGNC:24040 adiponectin receptor 1 Q96A54 Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. Plasma membrane (GO:0005886) golgi apparatus membrane 17 7 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Eukaryota ADIPOR2 HGNC:24041 adiponectin receptor 2 Q86V24 Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. Plasma membrane (GO:0005886) golgi apparatus membrane 15 7 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Cell.Organisms ADIRF HGNC:24043 adipogenesis regulatory factor Q15847 Nucleus. nucleus 100 0 nucleus nucleus Catarrhini Theria Mammalia ADK HGNC:257 adenosine kinase P55263 Cytoplasm (GO:0005737) 10215863 cytoplasm 53 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms ADM HGNC:259 adrenomedullin P35318 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11511315,12667630,12853384,11463574 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Craniata ADM2 HGNC:28898 adrenomedullin 2 Q7Z4H4 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Theria Theria Euteleostomi ADM5 HGNC:27293 adrenomedullin 5 (putative) C9JUS6 Secreted (Potential). secreted 38 0 secreted secreted NA NA Boreoeutheria ADNP HGNC:15766 activity-dependent neuroprotector homeobox Q9H2P0 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11013255,17081983,17081983 nucleus 11 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata ADNP2 HGNC:23803 ADNP homeobox 2 Q6IQ32 Nucleus (Probable). Nucleus (GO:0005634) secreted 21 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa ADO HGNC:23506 2-aminoethanethiol (cysteamine) dioxygenase Q96SZ5 nucleus 17 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota ADORA1 HGNC:262 adenosine A1 receptor P30542 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12475223,10502296 plasma membrane 100 7 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Eumetazoa ADORA2A HGNC:263 adenosine A2a receptor P29274 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10951119,10951119 plasma membrane 100 7 cytoplasm. plasma membrane multiple Human Bilateria Eumetazoa ADORA2B HGNC:264 adenosine A2b receptor P29275 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12080047 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Deuterostomia Metazoa ADORA3 HGNC:268 adenosine A3 receptor P33765 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endosome (GO:0005768) 12435805,12435805,12435805 plasma membrane 100 7 cytoplasm. endosome. plasma membrane multiple Human Bilateria Eumetazoa ADPGK HGNC:25250 ADP-dependent glucokinase Q9BRR6 Secreted (Potential). cytoplasm 38 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms ADPRH HGNC:269 ADP-ribosylarginine hydrolase P54922 Cytoplasm (GO:0005737) 9193669 mitochondrion membrane 6 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms ADPRHL1 HGNC:21303 ADP-ribosylhydrolase like 1 Q8NDY3 mitochondrion membrane 7 0 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Eukaryota ADPRHL2 HGNC:21304 ADP-ribosylhydrolase like 2 Q9NX46 Cytoplasm. Mitochondrion matrix. Nucleus. mitochondrion membrane 32 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms ADPRM HGNC:30925 ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent Q3LIE5 secreted 15 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms ADRA1A HGNC:277 adrenoceptor alpha 1A P35348 Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Cell surface (GO:0009986);Integral to membrane (GO:0016021) 10493934/8396931 plasma membrane 52 7 nucleus membrane. plasma membrane multiple Amniota Euteleostomi Opisthokonta ADRA1B HGNC:278 adrenoceptor alpha 1B P35368 Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Plasma membrane (GO:0005886) 1706716 plasma membrane 40 7 nucleus membrane. plasma membrane multiple Euteleostomi Deuterostomia Metazoa ADRA1D HGNC:280 adrenoceptor alpha 1D P25100 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7746284 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Eumetazoa ADRA2A HGNC:281 adrenoceptor alpha 2A P08913 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 plasma membrane 100 7 nucleus. plasma membrane multiple Bilateria Bilateria Metazoa ADRA2B HGNC:282 adrenoceptor alpha 2B P18089 Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26 mediates transport from the Golgi to the cell membrane. Plasma membrane (GO:0005886) 2164221 plasma membrane 100 7 plasma membrane plasma membrane NA NA Metazoa ADRA2C HGNC:283 adrenoceptor alpha 2C P18825 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Endosome (GO:0005768) ,10196213 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa ADRB1 HGNC:285 adrenoceptor beta 1 P08588 Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. Plasma membrane (GO:0005886) 10862778,16316992 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Metazoa ADRB2 HGNC:286 adrenoceptor beta 2, surface P07550 Cell membrane; Multi-pass membrane protein. Note=Colocalizes with VHL at the cell membrane. Plasma membrane (GO:0005886); Lysosome (GO:0005764) ,2541947,18544533,,,18544533, plasma membrane 100 7 lysosome. plasma membrane multiple Deuterostomia Bilateria Metazoa ADRB3 HGNC:288 adrenoceptor beta 3 P13945 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7565630 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa ADRBK1 HGNC:289 adrenergic, beta, receptor kinase 1 P25098 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12130708,1339451,12130708,1339451 nucleus 22 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms ADRBK2 HGNC:290 adrenergic, beta, receptor kinase 2 P35626 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12130708,12130708 nucleus 21 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms ADRM1 HGNC:15759 adhesion regulating molecule 1 Q16186 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Microsome (GO:0005792) 17139257,16990800,15819879,17139257,16990800,17081983,15819879,15819879,,16815440, secreted 19 0 cytoplasm. nucleus. secreted multiple Bilateria Eukaryota Eukaryota ADSL HGNC:291 adenylosuccinate lyase P30566 Cytoplasm (GO:0005737) 9195976 cytoplasm 46 0 cytoplasm cytoplasm NA NA Cell.Organisms ADSS HGNC:292 adenylosuccinate synthase P30520 Cytoplasm. Note=Partially associated with particulate fractions. Cytoplasm (GO:0005737) 8887278 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ADSSL1 HGNC:20093 adenylosuccinate synthase like 1 Q8N142 Cytoplasm. Cytoplasm (GO:0005737) 15786719 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ADTRP HGNC:21214 androgen-dependent TFPI-regulating protein Q96IZ2 Cell membrane; Multi-pass membrane protein. Note=Colocalized with TFPI and CAV1 in lipid rafts. plasma membrane 100 6 plasma membrane plasma membrane Tetrapoda Euteleostomi Eukaryota AEBP1 HGNC:303 AE binding protein 1 Q8IUX7 Isoform 1: Secreted (By similarity). Isoform 2: Cytoplasm (Probable). Nucleus (Probable). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11438679,9624159 secreted 33 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms AEBP2 HGNC:24051 AE binding protein 2 Q6ZN18 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 15 0 nucleus nucleus Euteleostomi Bilateria Eukaryota AEN HGNC:25722 apoptosis enhancing nuclease Q8WTP8 Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction. Nucleus (GO:0005634) 16171785 nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Cell.Organisms AES HGNC:307 amino-terminal enhancer of split Q08117 Nucleus (By similarity). Nucleus (GO:0005634) 10660609 nucleus 66 0 nucleus nucleus Mammalia Euteleostomi Eumetazoa AFAP1 HGNC:24017 actin filament associated protein 1 Q8N556 Cytoplasm, cytoskeleton. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9619827,12134071,9619827 cytoplasm 100 0 cytoplasm cytoplasm Human Chordata Eumetazoa AFAP1L1 HGNC:26714 actin filament associated protein 1-like 1 Q8TED9 Cytoplasm. Cell projection, podosome. Cell projection, invadopodium. Note=In the cytosol, associated with actin stress fibers. cytoplasm 40 0 cytoplasm cytoplasm Amniota Euteleostomi Bilateria AFAP1L2 HGNC:25901 actin filament associated protein 1-like 2 Q8N4X5 Cytoplasm. Cytoplasm (GO:0005737) 17412687 cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Eumetazoa AFF1 HGNC:7135 AF4/FMR2 family, member 1 P51825 Nucleus (Potential). Nucleus (GO:0005634) 9880680,14603337 nucleus 23 0 nucleus nucleus Amniota Amniota Eumetazoa AFF2 HGNC:3776 AF4/FMR2 family, member 2 P51816 Nucleus speckle. Note=When splicing is inhibited, accumlates in enlarged speckles. Nucleus (GO:0005634) 9299237 nucleus 100 1 nucleus nucleus Mammalia Euteleostomi NA AFF3 HGNC:6473 AF4/FMR2 family, member 3 P51826 Nucleus. Nucleus (GO:0005634) 8555498 nucleus 100 1 nucleus nucleus Amniota Euteleostomi Eumetazoa AFF4 HGNC:17869 AF4/FMR2 family, member 4 Q9UHB7 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11355014,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa AFG3L2 HGNC:315 AFG3-like AAA ATPase 2 Q9Y4W6 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10395799,15598749 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms AFM HGNC:316 afamin P43652 Secreted. Extracellular (GO:0005576) 8648639,16199891,16188874 secreted 100 0 secreted secreted Mammalia Mammalia Bilateria AFMID HGNC:20910 arylformamidase Q63HM1 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Predominantly cytosolic. Some fraction is nuclear (By similarity). cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms AFP HGNC:317 alpha-fetoprotein P02771 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12361680,12361680 secreted 100 0 cytoplasm. secreted multiple Theria Theria Bilateria AFTPH HGNC:25951 aftiphilin Q6ULP2 Cytoplasm. Note=Colocalizes with AP1G1 and clathrin. Cytoplasm (GO:0005737) 14665628 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Bilateria AGA HGNC:318 aspartylglucosaminidase P20933 Lysosome. Lysosome (GO:0005764) 10444340 cytoplasm 18 0 lysosome lysosome Bilateria Eukaryota Cell.Organisms AGAP1 HGNC:16922 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 Q9UPQ3 Cytoplasm. Note=Associates with the endocytic compartment. Endosome (GO:0005768) 12388557 cytoplasm 100 0 cytoplasm. endosome multiple Chordata Bilateria Cell.Organisms AGAP10 HGNC:23462 ArfGAP with GTPase domain, ankyrin repeat and PH domain 10 Q5T2P9 cytoplasm 72 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota AGAP11 HGNC:29421 ankyrin repeat and GTPase domain Arf GTPase activating protein 11 Q8TF27 cytoplasm 78 0 cytoplasm cytoplasm Chordata Bilateria NA AGAP2 HGNC:16921 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Q99490 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11136977,11136977,11136977 cytoplasm 49 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Chordata Bilateria Cell.Organisms AGAP3 HGNC:16923 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Q96P47 Cytoplasm. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies. cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms AGAP4 HGNC:23459 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 Q96P64 cytoplasm 74 0 cytoplasm cytoplasm Chordata Bilateria NA AGAP5 HGNC:23467 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 A6NIR3 cytoplasm 76 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms AGAP6 HGNC:23466 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 Q5VW22 cytoplasm 74 0 cytoplasm cytoplasm Chordata Bilateria NA AGAP7 HGNC:23465 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7 Q5VUJ5 cytoplasm 76 0 cytoplasm cytoplasm Chordata Bilateria NA AGAP8 HGNC:23464 ArfGAP with GTPase domain, ankyrin repeat and PH domain 8 Q5SRD3 cytoplasm 76 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms AGAP9 HGNC:23463 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 Q5VTM2 cytoplasm 68 0 cytoplasm cytoplasm Chordata Bilateria NA AGBL1 HGNC:26504 ATP/GTP binding protein-like 1 Q96MI9 Cytoplasm, cytosol (By similarity). cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms AGBL2 HGNC:26296 ATP/GTP binding protein-like 2 Q5U5Z8 Cytoplasm, cytosol (By similarity). cytoplasm 75 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms AGBL3 HGNC:27981 ATP/GTP binding protein-like 3 Q8NEM8 Cytoplasm, cytosol (By similarity). cytoplasm 68 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms AGBL4 HGNC:25892 ATP/GTP binding protein-like 4 Q5VU57 Cytoplasm, cytosol (By similarity). cytoplasm 90 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms AGBL5 HGNC:26147 ATP/GTP binding protein-like 5 Q8NDL9 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). cytoplasm 27 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms AGER HGNC:320 advanced glycosylation end product-specific receptor Q15109 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886);Extracellular (GO:0005576) 1378843/15555779 secreted 12 1 plasma membrane. secreted multiple Theria Theria NA AGFG1 HGNC:5175 ArfGAP with FG repeats 1 P52594 Nucleus. Cytoplasmic vesicle. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9368759,10613896,12429849 cytoplasm 13 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota AGFG2 HGNC:5177 ArfGAP with FG repeats 2 O95081 cytoplasm 18 0 cytoplasm cytoplasm Theria Theria Eukaryota AGGF1 HGNC:24684 angiogenic factor with G patch and FHA domains 1 Q8N302 Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634) 14961121,14961121,14961121/17081983 mitochondrion 28 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Cell.Organisms AGK HGNC:21869 acylglycerol kinase Q53H12 Mitochondrion membrane. Integral to membrane (GO:0016021) 15252046 cytoplasm 13 0 cytoplasm cytoplasm Bilateria Bilateria NA AGL HGNC:321 amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase P35573 Cytoplasm. Note=Under glycogenolytic conditions localizes to the nucleus. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 1505983,14718574 cytoplasm 100 2 cytoplasm. secreted multiple Bilateria Cell.Organisms Cell.Organisms AGMAT HGNC:18407 agmatine ureohydrolase (agmatinase) Q9BSE5 Mitochondrion. Mitochondrion (GO:0005739) 14648699 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms AGMO HGNC:33784 alkylglycerol monooxygenase Q6ZNB7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms AGO1 HGNC:3262 argonaute RISC catalytic component 1 Q9UL18 Cytoplasm, P-body. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota AGO2 HGNC:3263 argonaute RISC catalytic component 2 Q9UKV8 Cytoplasm, P-body. Nucleus. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. Cytoplasm (GO:0005737) cytoplasm 79 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota AGO3 HGNC:18421 argonaute RISC catalytic component 3 Q9H9G7 Cytoplasm, P-body. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota AGO4 HGNC:18424 argonaute RISC catalytic component 4 Q9HCK5 Cytoplasm, P-body. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota AGPAT1 HGNC:324 1-acylglycerol-3-phosphate O-acyltransferase 1 Q99943 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane (GO:0005789) 9461603 endoplasmic reticulum membrane 100 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms NA AGPAT2 HGNC:325 1-acylglycerol-3-phosphate O-acyltransferase 2 O15120 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 100 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Tetrapoda Cell.Organisms AGPAT3 HGNC:326 1-acylglycerol-3-phosphate O-acyltransferase 3 Q9NRZ7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 22 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms AGPAT4 HGNC:20885 1-acylglycerol-3-phosphate O-acyltransferase 4 Q9NRZ5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 19 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms AGPAT5 HGNC:20886 1-acylglycerol-3-phosphate O-acyltransferase 5 Q9NUQ2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Mitochondrion. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 12 4 endoplasmic reticulum membrane. mitochondrion multiple Deuterostomia Bilateria Cell.Organisms AGPAT6 HGNC:20880 1-acylglycerol-3-phosphate O-acyltransferase 6 Q86UL3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 12938015 endoplasmic reticulum membrane 100 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms AGPAT9 HGNC:28157 1-acylglycerol-3-phosphate O-acyltransferase 9 Q53EU6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Integral to membrane (GO:0016021) 17170135,17002884,17170135 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Eukaryota Cell.Organisms AGPS HGNC:327 alkylglycerone phosphate synthase O00116 Peroxisome membrane. Note=Localized to the inner aspect of the peroxisomal membrane. Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 9553082,15598749 peroxisome 93 0 mitochondrion. peroxisome multiple Bilateria Cell.Organisms Cell.Organisms AGR2 HGNC:328 anterior gradient 2 O95994 Secreted. Endoplasmic reticulum (By similarity). secreted 43 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms AGR3 HGNC:24167 anterior gradient 3 Q8TD06 Secreted (Probable). Extracellular (GO:0005576); Endosome (GO:0005768) 12477722,12592373,12477722 secreted 49 0 endosome. secreted multiple Euteleostomi Euteleostomi Holozoa AGRN HGNC:329 agrin O00468 Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Cell junction, synapse. Cell membrane; Single-pass type II membrane protein. Extracellular (GO:0005576) 1659950,1326608 secreted 16 0 plasma membrane. secreted multiple Deuterostomia Bilateria Eukaryota AGRP HGNC:330 agouti related protein homolog (mouse) O00253 Secreted. Golgi apparatus lumen. Extracellular (GO:0005576) 11344185,12153462 secreted 39 0 golgi apparatus. secreted multiple Amniota Euteleostomi Euteleostomi AGT HGNC:333 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) P01019 Secreted. Extracellular (GO:0005576) 11095476,16199891,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms AGTPBP1 HGNC:17258 ATP/GTP binding protein 1 Q9UPW5 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Mitochondrion (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11884758,11083920,11083920 cytoplasm 33 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms AGTR1 HGNC:336 angiotensin II receptor, type 1 P30556 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9766385 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa AGTR2 HGNC:338 angiotensin II receptor, type 2 P50052 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7719706 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi NA AGTRAP HGNC:13539 angiotensin II receptor-associated protein Q6RW13 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. Integral to membrane (GO:0016021) 11733189 endoplasmic reticulum membrane 31 3 endoplasmic reticulum membrane. golgi apparatus membrane multiple Tetrapoda Bilateria Opisthokonta AGXT HGNC:341 alanine-glyoxylate aminotransferase P21549 Peroxisome. Mitochondrion matrix. Note=Except in some HP1 patients where AGT is found in the mitochondrial matrix. Peroxisome (GO:0005777); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11085934,11085934,11085934 peroxisome 75 0 cytoplasm. mitochondrion. peroxisome multiple Cell.Organisms Cell.Organisms Cell.Organisms AGXT2 HGNC:14412 alanine--glyoxylate aminotransferase 2 Q9BYV1 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms AHCTF1 HGNC:24618 AT hook containing transcription factor 1 Q8WYP5 Cytoplasm (By similarity). Nucleus matrix (By similarity). Chromosome, centromere, kinetochore. Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107- 160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase. Nucleus (GO:0005634); Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 15561729,19059367,,17235358, nucleus 41 0 nucleus. nucleus membrane multiple Deuterostomia Bilateria Opisthokonta AHCY HGNC:343 adenosylhomocysteinase P23526 Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737) 12063172 cytoplasm 68 0 cytoplasm. melanosome multiple Cell.Organisms Cell.Organisms Cell.Organisms AHCYL1 HGNC:344 adenosylhomocysteinase-like 1 O43865 Endoplasmic reticulum (By similarity). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 12525476,12525476,12525476 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Bilateria Cell.Organisms AHCYL2 HGNC:22204 adenosylhomocysteinase-like 2 Q96HN2 endoplasmic reticulum 90 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Bilateria Cell.Organisms AHDC1 HGNC:25230 AT hook, DNA binding motif, containing 1 Q5TGY3 Nucleus (GO:0005634) plasma membrane 8 0 n/a n/a Tetrapoda Tetrapoda Craniata AHI1 HGNC:21575 Abelson helper integration site 1 Q8N157 Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cell junction, adherens junction. Cytoplasm (GO:0005737) 15322546 nucleus 7 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms AHNAK HGNC:347 AHNAK nucleoprotein Q09666 Nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoskeleton (GO:0005856) 12153988,1608957,15561729 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms AHNAK2 HGNC:20125 AHNAK nucleoprotein 2 Q8IVF2 Nucleus (By similarity). Nucleus (GO:0005634) 15007166 nucleus 21 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota AHR HGNC:348 aryl hydrocarbon receptor P35869 Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11768231,12237327,10497241,9446600,11259609,9446600,12597446,11259609 nucleus 19 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa AHRR HGNC:346 aryl-hydrocarbon receptor repressor A9YTQ3 Cytoplasm. Nucleus. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment. Nucleus (GO:0005634) 9887096 nucleus 16 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa AHSA1 HGNC:1189 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) O95433 Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 11554768,11554768 cytoplasm 12 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Cell.Organisms AHSA2 HGNC:20437 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) Q719I0 cytoplasm 5 0 cytoplasm cytoplasm Human Human Opisthokonta AHSG HGNC:349 alpha-2-HS-glycoprotein P02765 Secreted. Extracellular (GO:0005576) 6803836,15561729 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata AHSP HGNC:18075 alpha hemoglobin stabilizing protein Q9NZD4 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Mammalia Mammalia AICDA HGNC:13203 activation-induced cytidine deaminase Q9GZX7 Nucleus. Cytoplasm. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm. Cytoplasm (GO:0005737) 12011459 nucleus 32 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata AIDA HGNC:25761 axin interactor, dorsalization associated Q96BJ3 nucleus 46 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota AIF1 HGNC:352 allograft inflammatory factor 1 P55008 Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9614071,12714565,9614071 cytoplasm 22 0 cytoplasm. nucleus multiple Catarrhini Eukaryota NA AIF1L HGNC:28904 allograft inflammatory factor 1-like Q9BQI0 Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria. cytoplasm 27 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota AIFM1 HGNC:8768 apoptosis-inducing factor, mitochondrion-associated, 1 O95831 Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10913597,10744629,10913597,12022952,10913597,10744629,15652821,15561729 mitochondrion 40 2 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms AIFM2 HGNC:21411 apoptosis-inducing factor, mitochondrion-associated, 2 Q9BRQ8 Cytoplasm. Mitochondrion outer membrane. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12135761,11980907,11980907 cytoplasm 16 0 cytoplasm. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms AIFM3 HGNC:26398 apoptosis-inducing factor, mitochondrion-associated, 3 Q96NN9 Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis. Mitochondrial membrane (GO:0005740); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15764604,15764604,15764604,15598749 mitochondrion 100 0 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms AIG1 HGNC:21607 androgen-induced 1 Q9NVV5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11266118 plasma membrane 23 6 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota AIM1 HGNC:356 absent in melanoma 1 Q9Y4K1 Cytoskeleton (GO:0005856) 9096375 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms AIM1L HGNC:17295 absent in melanoma 1-like Q8N1P7 cytoplasm 36 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms AIM2 HGNC:357 absent in melanoma 2 O14862 Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles. Cytoplasm (GO:0005737) 10828447 nucleus 23 0 cytoplasm. nucleus multiple Euarchontoglires Euarchontoglires Eutheria AIMP1 HGNC:10648 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Q12904 Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle (By similarity). Secreted (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Microtubule (GO:0005874); Ribosome (GO:0005840) 14500886,14500886,11741979,15561729,15561729 cytoplasm 39 0 cytoplasm. nucleus. secreted multiple Opisthokonta Cell.Organisms Cell.Organisms AIMP2 HGNC:20609 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Q13155 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12819782,12819782 nucleus 51 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Holozoa AIP HGNC:358 aryl hydrocarbon receptor interacting protein O00170 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9111057,8972861,14730974,14730974 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota AIPL1 HGNC:359 aryl hydrocarbon receptor interacting protein-like 1 Q9NZN9 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12374762,11929855,15469903,12374762,10615133,15469903 cytoplasm 37 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota AIRE HGNC:360 autoimmune regulator O43918 Nucleus. Cytoplasm. Note=Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 9931333,9931333/9931333 nucleus 32 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota AJAP1 HGNC:30801 adherens junctions associated protein 1 Q9UKB5 Basolateral cell membrane; Single-pass type III membrane protein. Apical cell membrane; Single-pass type III membrane protein. Cell junction, adherens junction. Note=Mainly basolateral. Localization is mediated by AP1M2. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14595118,17081983 secreted 19 2 cytoplasm. plasma membrane multiple Tetrapoda Euteleostomi Craniata AJUBA HGNC:20250 ajuba LIM protein Q96IF1 Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus. Centrosome (GO:0005813); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 13678582,16413547,12417594,11860269,16137684,11029037,16137684,17081983 secreted 49 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota AK1 HGNC:361 adenylate kinase 1 P00568 Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10557075,12124227 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms AK2 HGNC:362 adenylate kinase 2 P54819 Mitochondrion intermembrane space. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 195572,10218571,15598749,10218571 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms AK3 HGNC:17376 adenylate kinase 3 Q9UIJ7 Mitochondrion matrix. Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 11485571/11485571,9504419,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms AK4 HGNC:363 adenylate kinase 4 P27144 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Opisthokonta Cell.Organisms AK5 HGNC:365 adenylate kinase 5 Q9Y6K8 Cytoplasm. Cytoplasm (GO:0005737) 10215863 cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms AK6 HGNC:49151 adenylate kinase 6 Q9Y3D8 Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells. nucleus 100 0 nucleus nucleus NA NA NA AK7 HGNC:20091 adenylate kinase 7 Q96M32 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota AK8 HGNC:26526 adenylate kinase 8 Q96MA6 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms AK9 HGNC:33814 adenylate kinase 9 Q5TCS8 cytoplasm 18 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms AKAP1 HGNC:367 A kinase (PRKA) anchor protein 1 Q92667 Mitochondrion outer membrane (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10995432,10995432,10995432,10352013 cytoplasm 15 1 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Bilateria Bilateria Opisthokonta AKAP10 HGNC:368 A kinase (PRKA) anchor protein 10 O43572 Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11248059,14531806 nucleus 44 0 cytoplasm. mitochondrion multiple Bilateria Bilateria Opisthokonta AKAP11 HGNC:369 A kinase (PRKA) anchor protein 11 Q9UKA4 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm. Peroxisome (GO:0005777); Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8621616,10864471,10864471,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus. peroxisome multiple Tetrapoda Euteleostomi Deuterostomia AKAP12 HGNC:370 A kinase (PRKA) anchor protein 12 Q02952 Cytoplasm, cell cortex (Probable). Cytoplasm, cytoskeleton (Probable). Note=May be part of the cortical cytoskeleton. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9000000,11316952,11766078,1522245,17081983/17081983,17081983 nucleus 20 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Euteleostomi AKAP13 HGNC:371 A kinase (PRKA) anchor protein 13 Q12802 Cytoplasm. Nucleus. Membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12270917,9891067,12270917,9891067,17081983,17081983 cytoplasm 31 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota AKAP14 HGNC:24061 A kinase (PRKA) anchor protein 14 Q86UN6 Cytoplasm (Probable). Axoneme (GO:0005930) 12475942 cytoplasm 16 0 cytoplasm cytoplasm Amniota Chordata Eumetazoa AKAP17A HGNC:18783 A kinase (PRKA) anchor protein 17A Q02040 Nucleus speckle. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1438229,16982639,16982639 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota AKAP2 HGNC:372 A kinase (PRKA) anchor protein 2 Q9Y2D5 Actin cytoskeleton (GO:0015629); Plasma membrane (GO:0005886) 9497389,9497389 nucleus 82 0 nucleus nucleus NA NA Craniata AKAP3 HGNC:373 A kinase (PRKA) anchor protein 3 O75969 Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12606363,17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Theria Theria Euteleostomi AKAP4 HGNC:374 A kinase (PRKA) anchor protein 4 Q5JQC9 Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum. Cytoplasm (GO:0005737) 11476771,9822690 cytoplasm 20 0 cytoplasm cytoplasm Mammalia Mammalia NA AKAP5 HGNC:375 A kinase (PRKA) anchor protein 5 P24588 Membrane; Lipid-anchor. Note=Associates with lipid rafts. Plasma membrane (GO:0005886) 12507994,11557526,11287423,10537145 nucleus 94 0 nucleus nucleus Amniota Amniota Amniota AKAP6 HGNC:376 A kinase (PRKA) anchor protein 6 Q13023 Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences. Nucleus (GO:0005634); Sarcoplasmic reticulum (GO:0016529) 10413680,7721854 cytoplasm 13 0 endoplasmic reticulum. nucleus multiple Euteleostomi Euteleostomi Bilateria AKAP7 HGNC:377 A kinase (PRKA) anchor protein 7 O43687 Isoform Alpha: Lateral cell membrane; Lipid- anchor. Isoform Beta: Apical cell membrane; Lipid- anchor. Note=Targeted predominantly to the apical membrane. Plasma membrane (GO:0005886) 9545239,10613906 nucleus 45 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota AKAP8 HGNC:378 A kinase (PRKA) anchor protein 8 O43823 Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9473338,17081983,10601332,17081983 nucleus 100 0 cytoplasm. nucleus multiple Amniota Amniota Craniata AKAP8L HGNC:29857 A kinase (PRKA) anchor protein 8-like Q9ULX6 Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10761695,10748171,11034899,15561729,10748171,17081983 nucleus 24 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata AKAP9 HGNC:379 A kinase (PRKA) anchor protein 9 Q99996 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Note=Cytoplasmic in parietal cells. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Centrosome (GO:0005813) 9915845,10358086,10202149,10358086 cytoplasm 14 0 cytoplasm. golgi apparatus multiple Tetrapoda Euteleostomi Opisthokonta AKIP1 HGNC:1170 A kinase (PRKA) interacting protein 1 Q9NQ31 Nucleus. Note=Locates to punctate spots. Nucleus (GO:0005634) 15630084 nucleus 100 0 nucleus nucleus Amniota Deuterostomia Bilateria AKIRIN1 HGNC:25744 akirin 1 Q9H9L7 Nucleus. nucleus 100 0 nucleus nucleus Human Euteleostomi Eukaryota AKIRIN2 HGNC:21407 akirin 2 Q53H80 Nucleus. Cytoplasm (GO:0005737) 17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa AKNA HGNC:24108 AT-hook transcription factor Q7Z591 Nucleus. Nucleus (GO:0005634) 11268217,17081983 nucleus 100 0 nucleus nucleus Mammalia Mammalia Eumetazoa AKNAD1 HGNC:28398 AKNA domain containing 1 Q5T1N1 nucleus 18 0 nucleus nucleus Mammalia Tetrapoda Deuterostomia AKR1A1 HGNC:380 aldo-keto reductase family 1, member A1 (aldehyde reductase) P14550 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11716357,9693960,11716357,9693960 cytoplasm 40 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms AKR1B1 HGNC:381 aldo-keto reductase family 1, member B1 (aldose reductase) P15121 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10510318,6417042,2112546 cytoplasm 100 0 cytoplasm. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms AKR1B10 HGNC:382 aldo-keto reductase family 1, member B10 (aldose reductase) O60218 Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway. cytoplasm 65 0 lysosome. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms AKR1B15 HGNC:37281 aldo-keto reductase family 1, member B15 C9JRZ8 cytoplasm 59 0 cytoplasm cytoplasm NA NA Cell.Organisms AKR1C1 HGNC:384 aldo-keto reductase family 1, member C1 Q04828 Cytoplasm. Cytoplasm (GO:0005737) 10510318 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota NA AKR1C2 HGNC:385 aldo-keto reductase family 1, member C2 P52895 Cytoplasm (Potential). Cytosol (GO:0005829) 8486699 cytoplasm 97 0 cytoplasm cytoplasm Mammalia Eukaryota NA AKR1C3 HGNC:386 aldo-keto reductase family 1, member C3 P42330 Cytoplasm. Cytoplasm (GO:0005737) 7650035 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota NA AKR1C4 HGNC:387 aldo-keto reductase family 1, member C4 P17516 Cytoplasm. Cytoplasm (GO:0005737) 2187532 cytoplasm 100 0 cytoplasm cytoplasm Human Catarrhini NA AKR1CL1 HGNC:23469 aldo-keto reductase family 1, member C-like 1 Q5T2L2 Cytoplasm (Potential). cytoplasm 62 0 cytoplasm cytoplasm Human Catarrhini NA AKR1D1 HGNC:388 aldo-keto reductase family 1, member D1 P51857 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms AKR1E2 HGNC:23437 aldo-keto reductase family 1, member E2 Q96JD6 Cytoplasm (Potential). cytoplasm 68 0 cytoplasm cytoplasm Human Eutheria Cell.Organisms AKR7A2 HGNC:389 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) O43488 Golgi apparatus (By similarity). Cytoplasm. Cytoplasm (GO:0005737) 9576847 cytoplasm 85 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms AKR7A3 HGNC:390 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) O95154 Cytoplasm. Cytoplasm (GO:0005737) 10383892 cytoplasm 100 0 cytoplasm cytoplasm Human Euarchontoglires Cell.Organisms AKR7L HGNC:24056 aldo-keto reductase family 7-like Q8NHP1 cytoplasm 90 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms AKT1 HGNC:391 v-akt murine thymoma viral oncogene homolog 1 P31749 Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9395488,9395488,16717100,17081983,11313479,9395488 cytoplasm 32 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms AKT1S1 HGNC:28426 AKT1 substrate 1 (proline-rich) Q96B36 Cytoplasm, cytosol (By similarity). Note=Found in the cytosolic fraction of the brain (By similarity). Cytoplasm (GO:0005737) 14973226 cytoplasm 91 0 cytoplasm cytoplasm Theria Euteleostomi Eumetazoa AKT2 HGNC:392 v-akt murine thymoma viral oncogene homolog 2 P31751 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11781143,11781143,9374542 cytoplasm 29 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms AKT3 HGNC:393 v-akt murine thymoma viral oncogene homolog 3 Q9Y243 Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Plasma membrane (GO:0005886); Perinuclear region (GO:0048471); Cytosol (GO:0005829) 11387345,12176997,11387345 cytoplasm 31 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms AKTIP HGNC:16710 AKT interacting protein Q9H8T0 Cytoplasm. Cell membrane; Peripheral membrane protein. Plasma membrane (GO:0005886) 14749367 nucleus 15 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ALAD HGNC:395 aminolevulinate dehydratase P13716 Cytoplasm (GO:0005737) 3327436 mitochondrion 29 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ALAS1 HGNC:396 aminolevulinate, delta-, synthase 1 P13196 Mitochondrion matrix. Mitochondrial matrix (GO:0005759); Cytoplasm (GO:0005737) 2095458,8424176,8424176 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms ALAS2 HGNC:397 aminolevulinate, delta-, synthase 2 P22557 Mitochondrion matrix. Mitochondrion (GO:0005739) 10727444 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ALB HGNC:399 albumin P02768 Secreted. Extracellular (GO:0005576) 6275391,16188874 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Bilateria ALCAM HGNC:400 activated leukocyte cell adhesion molecule Q13740 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12843199,10673383 secreted 9 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Metazoa ALDH16A1 HGNC:28114 aldehyde dehydrogenase 16 family, member A1 Q8IZ83 peroxisome 15 0 peroxisome peroxisome Deuterostomia Deuterostomia Cell.Organisms ALDH18A1 HGNC:9722 aldehyde dehydrogenase 18 family, member A1 P54886 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 11092761,15598749 cytoplasm 19 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ALDH1A1 HGNC:402 aldehyde dehydrogenase 1 family, member A1 P00352 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ALDH1A2 HGNC:15472 aldehyde dehydrogenase 1 family, member A2 O94788 Cytoplasm. Extracellular (GO:0005576) 14718574 cytoplasm 100 0 cytoplasm. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms ALDH1A3 HGNC:409 aldehyde dehydrogenase 1 family, member A3 P47895 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11585737 cytoplasm 92 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ALDH1B1 HGNC:407 aldehyde dehydrogenase 1 family, member B1 P30837 Mitochondrion matrix. Mitochondrion (GO:0005739) 7779080 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ALDH1L1 HGNC:3978 aldehyde dehydrogenase 1 family, member L1 O75891 Cytoplasm. Cytoplasm (GO:0005737) 7972060 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ALDH1L2 HGNC:26777 aldehyde dehydrogenase 1 family, member L2 Q3SY69 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ALDH2 HGNC:404 aldehyde dehydrogenase 2 family (mitochondrial) P05091 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 1306115,11468345,15033988,11468345 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms ALDH3A1 HGNC:405 aldehyde dehydrogenase 3 family, member A1 P30838 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9514081,1306115,15905174,15905174 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ALDH3A2 HGNC:403 aldehyde dehydrogenase 3 family, member A2 P51648 Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 11408337,15110319 cytoplasm 59 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Cell.Organisms Cell.Organisms ALDH3B1 HGNC:410 aldehyde dehydrogenase 3 family, member B1 P43353 Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. Mitochondrial matrix (GO:0005759) cytoplasm 42 0 cytoplasm cytoplasm Eukaryota Cell.Organisms NA ALDH3B2 HGNC:411 aldehyde dehydrogenase 3 family, member B2 P48448 cytoplasm 41 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms ALDH4A1 HGNC:406 aldehyde dehydrogenase 4 family, member A1 P30038 Mitochondrion matrix. Mitochondrion (GO:0005739) 8621661,15598749 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms ALDH5A1 HGNC:408 aldehyde dehydrogenase 5 family, member A1 P51649 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 7814412,6470007,17081983 mitochondrion 100 0 mitochondrion. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms ALDH6A1 HGNC:7179 aldehyde dehydrogenase 6 family, member A1 Q02252 Mitochondrion. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 1527093,15033988,14718574 mitochondrion 100 0 mitochondrion. secreted multiple Bilateria Cell.Organisms Cell.Organisms ALDH7A1 HGNC:877 aldehyde dehydrogenase 7 family, member A1 P49419 Mitochondrion. Nucleus. Isoform 2: Cytoplasm, cytosol. mitochondrion 14 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms ALDH8A1 HGNC:15471 aldehyde dehydrogenase 8 family, member A1 Q9H2A2 Cytoplasm (By similarity). cytoplasm 87 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms ALDH9A1 HGNC:412 aldehyde dehydrogenase 9 family, member A1 P49189 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11790142 cytoplasm 88 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms ALDOA HGNC:414 aldolase A, fructose-bisphosphate P04075 Cytoplasm (GO:0005737); Cytosol (GO:0005829); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 955981,766744,17081983,16263121,15598749,17081983 cytoplasm 62 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ALDOB HGNC:417 aldolase B, fructose-bisphosphate P05062 Cytoplasm (GO:0005737) 11241348 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms ALDOC HGNC:418 aldolase C, fructose-bisphosphate P09972 Mitochondrion (GO:0005739) 15598749 cytoplasm 63 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ALG1 HGNC:18294 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase Q9BT22 Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 10704531,17081983 plasma membrane 21 3 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Human Deuterostomia Eukaryota ALG10 HGNC:23162 ALG10, alpha-1,2-glucosyltransferase Q5BKT4 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14525949 endoplasmic reticulum membrane 100 12 endoplasmic reticulum membrane. plasma membrane multiple Opisthokonta Eukaryota Eukaryota ALG10B HGNC:31088 ALG10B, alpha-1,2-glucosyltransferase Q5I7T1 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 14525949 endoplasmic reticulum membrane 95 12 plasma membrane plasma membrane Opisthokonta Eukaryota Eukaryota ALG11 HGNC:32456 ALG11, alpha-1,2-mannosyltransferase Q2TAA5 Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). endoplasmic reticulum membrane 34 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple NA NA Cell.Organisms ALG12 HGNC:19358 ALG12, alpha-1,6-mannosyltransferase Q9BV10 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 23 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota ALG13 HGNC:30881 ALG13, UDP-N-acetylglucosaminyltransferase subunit Q9NP73 Isoform 2: Endoplasmic reticulum (Probable). Note=Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14. endoplasmic reticulum 25 0 endoplasmic reticulum endoplasmic reticulum Amniota Euteleostomi Cell.Organisms ALG14 HGNC:28287 ALG14, UDP-N-acetylglucosaminyltransferase subunit Q96F25 Endoplasmic reticulum membrane; Single-pass membrane protein (Probable). secreted 63 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms Cell.Organisms ALG1L HGNC:33721 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like Q6GMV1 nucleus 34 0 nucleus nucleus Homininae Homininae Eukaryota ALG2 HGNC:23159 ALG2, alpha-1,3/1,6-mannosyltransferase Q9H553 Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 12684507 endoplasmic reticulum membrane 30 1 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms ALG3 HGNC:23056 ALG3, alpha-1,3- mannosyltransferase Q92685 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum membrane (GO:0005789) 15108280 endoplasmic reticulum membrane 35 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota ALG5 HGNC:20266 ALG5, dolichyl-phosphate beta-glucosyltransferase Q9Y673 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 48 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms Cell.Organisms ALG6 HGNC:23157 ALG6, alpha-1,3-glucosyltransferase Q9Y672 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9710431,12200473 endoplasmic reticulum membrane 23 12 endoplasmic reticulum. golgi apparatus multiple Opisthokonta Eukaryota Eukaryota ALG8 HGNC:23161 ALG8, alpha-1,3-glucosyltransferase Q9BVK2 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783) 12200473,12200473 endoplasmic reticulum membrane 35 14 endoplasmic reticulum endoplasmic reticulum Human Deuterostomia Eukaryota ALG9 HGNC:15672 ALG9, alpha-1,2-mannosyltransferase Q9H6U8 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783) 15148656 endoplasmic reticulum membrane 3 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Eukaryota NA ALK HGNC:427 anaplastic lymphoma receptor tyrosine kinase Q9UM73 Cell membrane; Single-pass type I membrane protein. Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. Plasma membrane (GO:0005886); Cell surface (GO:0009986) 9053841,17681947 plasma membrane 100 2 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms ALKBH1 HGNC:17911 alkB, alkylation repair homolog 1 (E. coli) Q13686 Mitochondrion. Nucleus (By similarity). Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity). Nucleus (GO:0005634) nucleus 44 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ALKBH2 HGNC:32487 alkB, alkylation repair homolog 2 (E. coli) Q6NS38 Nucleus. Note=Detected in replication foci during S-phase. Nucleoplasm (GO:0005654); Nucleolus (GO:0005730) 12594517,12594517 nucleus 100 0 nucleus nucleus Euteleostomi Opisthokonta Cell.Organisms ALKBH3 HGNC:30141 alkB, alkylation repair homolog 3 (E. coli) Q96Q83 Cytoplasm. Nucleus. nucleus 24 0 cytoplasm. nucleus multiple Chordata Cell.Organisms Cell.Organisms ALKBH4 HGNC:21900 alkB, alkylation repair homolog 4 (E. coli) Q9NXW9 Cytoplasm. Nucleus. nucleus 14 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota ALKBH5 HGNC:25996 alkB, alkylation repair homolog 5 (E. coli) Q6P6C2 Nucleus speckle. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota ALKBH6 HGNC:28243 alkB, alkylation repair homolog 6 (E. coli) Q3KRA9 Cytoplasm. Nucleus. nucleus 10 0 cytoplasm. nucleus multiple NA NA Cell.Organisms ALKBH7 HGNC:21306 alkB, alkylation repair homolog 7 (E. coli) Q9BT30 Cytoplasm. Nucleus. Secreted (Potential). Note=Has a predicted N-terminal signal sequence, indicating it may be secreted. Detected in cytoplasm and nucleus when expressed as fusion protein with an N-terminal tag (PubMed:17979886). mitochondrion 100 0 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota ALKBH8 HGNC:25189 alkB, alkylation repair homolog 8 (E. coli) Q96BT7 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nucleus (GO:0005634) nucleus 65 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ALLC HGNC:17377 allantoicase Q8N6M5 cytoplasm 20 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms ALMS1 HGNC:428 Alstrom syndrome 1 Q8TCU4 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with centrosomes and basal bodies at the base of primary cilia. Specifically locates to the proximal ends of centrioles and basal bodies. Colocalizes partially with NCAPD2 at these sites. During mitosis localizes to both spindle poles. Nucleus (GO:0005634) 11941369 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Chordata Eumetazoa ALOX12 HGNC:429 arachidonate 12-lipoxygenase P18054 Cytoplasm. Cytoplasm (GO:0005737) 8912711,7868854,9082968 cytoplasm 14 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms ALOX12B HGNC:430 arachidonate 12-lipoxygenase, 12R type O75342 Cytoplasm (GO:0005737) 9837935 mitochondrion 13 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms ALOX15 HGNC:433 arachidonate 15-lipoxygenase P16050 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10464294,11023533,9414270 cytoplasm 13 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms ALOX15B HGNC:434 arachidonate 15-lipoxygenase, type B O15296 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Lysosome (GO:0005764); Peroxisome (GO:0005777) 12704195,12704195,12704195,12704195,12704195,12704195,12704195 mitochondrion 17 0 cytoplasm. endoplasmic reticulum. lysosome. mitochondrion. nucleus. peroxisome multiple Deuterostomia Cell.Organisms Cell.Organisms ALOX5 HGNC:435 arachidonate 5-lipoxygenase P09917 Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 3134355,10673219,8245774,10673219,10514459 cytoplasm 15 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms NA ALOX5AP HGNC:436 arachidonate 5-lipoxygenase-activating protein P20292 Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 1673682,8071328,8071328,8071328 endoplasmic reticulum membrane 44 2 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus. nucleus membrane. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms ALOXE3 HGNC:13743 arachidonate lipoxygenase 3 Q9BYJ1 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms ALPI HGNC:437 alkaline phosphatase, intestinal P09923 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 12660142,12577238,12577238,12466148 secreted 79 1 cytoplasm. nucleus. plasma membrane. secreted multiple Opisthokonta Cell.Organisms Cell.Organisms ALPK1 HGNC:20917 alpha-kinase 1 Q96QP1 nucleus 49 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ALPK2 HGNC:20565 alpha-kinase 2 Q86TB3 nucleus 25 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ALPK3 HGNC:17574 alpha-kinase 3 Q96L96 Nucleus (By similarity). Nucleus (GO:0005634) 11418590 nucleus 68 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ALPL HGNC:438 alkaline phosphatase, liver/bone/kidney P05186 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9814472,9814472 secreted 69 1 cytoplasm. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms ALPP HGNC:439 alkaline phosphatase, placental P05187 Cell membrane; Lipid-anchor, GPI-anchor. Extracellular (GO:0005576); Nucleus (GO:0005634) ,17000644 secreted 78 1 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms ALPPL2 HGNC:441 alkaline phosphatase, placental-like 2 P10696 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 2578098,1581814 secreted 80 1 plasma membrane. secreted multiple Opisthokonta Cell.Organisms Cell.Organisms ALS2 HGNC:443 amyotrophic lateral sclerosis 2 (juvenile) Q96Q42 Golgi apparatus (GO:0005794) 11586297 cytoplasm 21 1 golgi apparatus golgi apparatus Tetrapoda Bilateria Cell.Organisms ALS2CL HGNC:20605 ALS2 C-terminal like Q60I27 Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells. Cytoplasm (GO:0005737); Endosome (GO:0005768) 15388334,15388334 cytoplasm 100 1 cytoplasm. endosome multiple Theria Tetrapoda Cell.Organisms ALS2CR11 HGNC:14438 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 Q53TS8 nucleus 77 0 nucleus nucleus Mammalia Mammalia Eumetazoa ALS2CR12 HGNC:14439 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 Q96Q35 cytoplasm 11 0 cytoplasm cytoplasm Theria Deuterostomia Deuterostomia ALX1 HGNC:1494 ALX homeobox 1 Q15699 Nucleus. Nucleus (GO:0005634) 9753625,7592751 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ALX3 HGNC:449 ALX homeobox 3 O95076 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Mammalia Euteleostomi Eukaryota ALX4 HGNC:450 ALX homeobox 4 Q9H161 Nucleus. Nucleus (GO:0005634) 11696550 nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Eukaryota ALYREF HGNC:19071 Aly/REF export factor Q86V81 Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 10488337,11790298,15635413,15598749 mitochondrion 25 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms AMACR HGNC:451 alpha-methylacyl-CoA racemase Q9UHK6 Peroxisome. Mitochondrion. Cytosol (GO:0005829);Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Peroxisome (GO:0005777) 14960364/11956072,14960364,11060344,11060344 mitochondrion 13 0 cytoplasm. mitochondrion. peroxisome multiple NA NA Cell.Organisms AMBN HGNC:452 ameloblastin (enamel matrix protein) Q9NP70 Secreted, extracellular space, extracellular matrix. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 9032019,9032019,10946765 secreted 100 0 cytoplasm. golgi apparatus. secreted multiple Mammalia Tetrapoda Tetrapoda AMBP HGNC:453 alpha-1-microglobulin/bikunin precursor P02760 Secreted. Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 7535251,2419908,16188874,7685189,7685189,9671439,9671439 secreted 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms AMBRA1 HGNC:25990 autophagy/beclin-1 regulator 1 Q9C0C7 Cytoplasmic vesicle, autophagosome (By similarity). nucleus 24 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms AMD1 HGNC:457 adenosylmethionine decarboxylase 1 P17707 Cytoplasm (GO:0005737) 7634128 cytoplasm 16 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms AMDHD1 HGNC:28577 amidohydrolase domain containing 1 Q96NU7 cytoplasm 11 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms AMDHD2 HGNC:24262 amidohydrolase domain containing 2 Q9Y303 cytoplasm 57 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms AMELX HGNC:461 amelogenin, X-linked Q99217 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 1734713 secreted 100 0 secreted secreted Theria Tetrapoda Craniata AMELY HGNC:462 amelogenin, Y-linked Q99218 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 1734713 secreted 100 0 secreted secreted Theria Tetrapoda Craniata AMER1 HGNC:26837 APC membrane recruitment protein 1 Q5JTC6 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2. nucleus 20 0 cytoplasm. nucleus multiple Theria Euteleostomi Euteleostomi AMER2 HGNC:26360 APC membrane recruitment protein 2 Q8N7J2 Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. cytoplasm 15 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata AMER3 HGNC:26771 APC membrane recruitment protein 3 Q8N944 Cell membrane; Peripheral membrane protein (By similarity). Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2 (By similarity). nucleus 92 0 nucleus nucleus Amniota Amniota Craniata AMFR HGNC:463 autocrine motility factor receptor, E3 ubiquitin protein ligase Q9UKV5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 11724934,16275660,16275660 endoplasmic reticulum membrane 100 8 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Eukaryota Cell.Organisms AMH HGNC:464 anti-Mullerian hormone P03971 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 1750488,1750488 secreted 100 0 cytoplasm. secreted multiple Amniota Euteleostomi Eumetazoa AMHR2 HGNC:465 anti-Mullerian hormone receptor, type II Q16671 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8940028 plasma membrane 12 1 plasma membrane plasma membrane Eutheria Euteleostomi Cell.Organisms AMICA1 HGNC:19084 adhesion molecule, interacts with CXADR antigen 1 Q86YT9 Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN. Plasma membrane (GO:0005886) 12869515 plasma membrane 20 1 plasma membrane plasma membrane Eutheria Amniota Bilateria AMIGO1 HGNC:20824 adhesion molecule with Ig-like domain 1 Q86WK6 Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, axon (By similarity). Note=Associated with axons of neuronal cells (By similarity). Cell projection (GO:0042995) 12629050 plasma membrane 87 1 plasma membrane plasma membrane Theria Euteleostomi Eukaryota AMIGO2 HGNC:24073 adhesion molecule with Ig-like domain 2 Q86SJ2 Cell membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity). Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microsome (GO:0005792) 15107827,12843293,12843293,17081983,12843293,12843293 plasma membrane 27 1 cytoplasm. nucleus. plasma membrane multiple Amniota Amniota Cell.Organisms AMIGO3 HGNC:24075 adhesion molecule with Ig-like domain 3 Q86WK7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 12629050 plasma membrane 25 1 plasma membrane plasma membrane Mammalia Euteleostomi Holozoa AMMECR1 HGNC:467 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 Q9Y4X0 secreted 24 0 secreted secreted Cell.Organisms Cell.Organisms Cell.Organisms AMMECR1L HGNC:28658 AMMECR1-like Q6DCA0 cytoplasm 16 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms AMN HGNC:14604 amnion associated transmembrane protein Q9BXJ7 Membrane; Single-pass type I membrane protein (Potential). secreted 59 1 secreted secreted Euteleostomi Bilateria Eumetazoa AMN1 HGNC:27281 antagonist of mitotic exit network 1 homolog (S. cerevisiae) Q8IY45 cytoplasm 14 0 cytoplasm cytoplasm Amniota Deuterostomia Cell.Organisms AMOT HGNC:17810 angiomotin Q4VCS5 Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein. Plasma membrane (GO:0005886) 11257124,12902404 secreted 100 0 secreted secreted Chordata Chordata Metazoa AMOTL1 HGNC:17811 angiomotin like 1 Q8IY63 Cell junction, tight junction (By similarity). Plasma membrane (GO:0005886) 11733531 secreted 85 0 secreted secreted Chordata Chordata Metazoa AMOTL2 HGNC:17812 angiomotin like 2 Q9Y2J4 Recycling endosome (By similarity). secreted 36 0 secreted secreted Euteleostomi Euteleostomi Metazoa AMPD1 HGNC:468 adenosine monophosphate deaminase 1 P23109 Cytoplasm (GO:0005737) 12213808 cytoplasm 38 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms AMPD2 HGNC:469 adenosine monophosphate deaminase 2 Q01433 Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/17081983 cytoplasm 50 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms AMPD3 HGNC:470 adenosine monophosphate deaminase 3 Q01432 Cytoplasm (GO:0005737) 8140814 cytoplasm 37 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms AMPH HGNC:471 amphiphysin P49418 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 8245793 cytoplasm 12 0 cytoplasm cytoplasm Amniota Opisthokonta Opisthokonta AMT HGNC:473 aminomethyltransferase P48728 Mitochondrion. Mitochondrion (GO:0005739) 6111451 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms AMTN HGNC:33188 amelotin Q6UX39 Secreted (Probable). secreted 51 0 secreted secreted Theria Theria Mammalia AMY1A HGNC:474 amylase, alpha 1A (salivary) P04745 Secreted. Extracellular (GO:0005576) 11858714 secreted 100 0 secreted secreted NA NA Cell.Organisms AMY1B HGNC:475 amylase, alpha 1B (salivary) P04745 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms AMY1C HGNC:476 amylase, alpha 1C (salivary) P04745 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms AMY2A HGNC:477 amylase, alpha 2A (pancreatic) P04746 Secreted, extracellular space. Extracellular (GO:0005576) 11376382,14718574 secreted 100 0 secreted secreted NA NA Cell.Organisms AMY2B HGNC:478 amylase, alpha 2B (pancreatic) P19961 Secreted (By similarity). Extracellular (GO:0005576) 8268204 secreted 98 0 secreted secreted NA NA Cell.Organisms AMZ1 HGNC:22231 archaelysin family metallopeptidase 1 Q400G9 nucleus 73 0 nucleus nucleus Amniota Amniota Eukaryota AMZ2 HGNC:28041 archaelysin family metallopeptidase 2 Q86W34 nucleus 51 0 nucleus nucleus Eutheria Cell.Organisms NA ANAPC1 HGNC:19988 anaphase promoting complex subunit 1 Q9H1A4 Chromosome (GO:0005694) 11129339 plasma membrane 51 4 nucleus nucleus Eukaryota Eukaryota Eukaryota ANAPC10 HGNC:24077 anaphase promoting complex subunit 10 Q9UM13 Nucleus (GO:0005634) 10498862 cytoplasm 15 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ANAPC11 HGNC:14452 anaphase promoting complex subunit 11 Q9NYG5 Cytoplasm. Nucleus. nucleus 22 0 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota ANAPC13 HGNC:24540 anaphase promoting complex subunit 13 Q9BS18 Nucleus (Probable). nucleus 43 0 nucleus nucleus Tetrapoda Deuterostomia Bilateria ANAPC15 HGNC:24531 anaphase promoting complex subunit 15 P60006 nucleus 91 0 nucleus nucleus Theria Euteleostomi Bilateria ANAPC16 HGNC:26976 anaphase promoting complex subunit 16 Q96DE5 Cytoplasm. Nucleus. nucleus 30 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata ANAPC2 HGNC:19989 anaphase promoting complex subunit 2 Q9UJX6 nucleus 24 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ANAPC4 HGNC:19990 anaphase promoting complex subunit 4 Q9UJX5 Nucleus (GO:0005634) nucleus 10 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ANAPC5 HGNC:15713 anaphase promoting complex subunit 5 Q9UJX4 Nucleus (GO:0005634) 15082755 cytoplasm 31 0 nucleus nucleus Deuterostomia Eukaryota NA ANAPC7 HGNC:17380 anaphase promoting complex subunit 7 Q9UJX3 Cytoplasm (GO:0005737); Microtubule (GO:0005874) ,15561729 cytoplasm 9 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms ANG HGNC:483 angiogenin, ribonuclease, RNase A family, 5 P03950 Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA. Extracellular (GO:0005576); Nucleolus (GO:0005730); Nucleus (GO:0005634) 7945327,7945327,7945327 secreted 34 0 nucleus. secreted multiple Tetrapoda Euteleostomi Euteleostomi ANGEL1 HGNC:19961 angel homolog 1 (Drosophila) Q9UNK9 secreted 54 0 secreted secreted Amniota Eukaryota Eukaryota ANGEL2 HGNC:30534 angel homolog 2 (Drosophila) Q5VTE6 nucleus 26 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ANGPT1 HGNC:484 angiopoietin 1 Q15389 Secreted. Extracellular (GO:0005576) 8980223 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Holozoa ANGPT2 HGNC:485 angiopoietin 2 O15123 Secreted. Extracellular (GO:0005576) 11447223 secreted 100 0 secreted secreted Chordata Chordata Holozoa ANGPT4 HGNC:487 angiopoietin 4 Q9Y264 Secreted (Probable). Extracellular (GO:0005576) 10051567 secreted 34 0 secreted secreted Theria Theria Cell.Organisms ANGPTL1 HGNC:489 angiopoietin-like 1 O95841 Secreted. Extracellular (GO:0005576) 10025962 secreted 100 0 secreted secreted Amniota Euteleostomi Holozoa ANGPTL2 HGNC:490 angiopoietin-like 2 Q9UKU9 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa ANGPTL3 HGNC:491 angiopoietin-like 3 Q9Y5C1 Secreted (By similarity). Extracellular (GO:0005576) 11877390,10644446,12565906 secreted 25 0 secreted secreted Euteleostomi Euteleostomi Metazoa ANGPTL4 HGNC:16039 angiopoietin-like 4 Q9BY76 Secreted. Secreted, extracellular space, extracellular matrix (By similarity). Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). Extracellular (GO:0005576) 10698685 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa ANGPTL5 HGNC:19705 angiopoietin-like 5 Q86XS5 Secreted (Potential). secreted 26 0 secreted secreted Euteleostomi Euteleostomi Metazoa ANGPTL6 HGNC:23140 angiopoietin-like 6 Q8NI99 Secreted (Probable). Extracellular (GO:0005576) 14764539 secreted 36 0 secreted secreted Theria Theria Metazoa ANGPTL7 HGNC:24078 angiopoietin-like 7 O43827 Secreted (Probable). Extracellular (GO:0005576) 11682471 secreted 34 0 secreted secreted Euteleostomi Euteleostomi Metazoa ANHX HGNC:40024 anomalous homeobox E9PGG2 Nucleus (By similarity). nucleus 19 0 nucleus nucleus NA NA Metazoa ANK1 HGNC:492 ankyrin 1, erythrocytic P16157 Isoform Er1: Cytoplasm, cytoskeleton. Isoform Mu17: Membrane. Cytoplasm, myofibril, sarcomere, M line. Isoform Mu18: Sarcoplasmic reticulum (Probable). Isoform Mu19: Sarcoplasmic reticulum (Probable). Isoform Mu20: Sarcoplasmic reticulum (Probable). Sarcoplasmic reticulum (GO:0016529); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Plasma membrane (GO:0005886) 9024692,16962094,9024692,9628825,9430667 nucleus 22 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Cell.Organisms Cell.Organisms ANK2 HGNC:493 ankyrin 2, neuronal Q01484 Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line (By similarity). Apical cell membrane (By similarity). Cell membrane. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes (By similarity). In skeletal muscle, localizes to neuromuscular junctions (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023); Nucleus (GO:0005634);Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 1830053,11149946,10579720,11149946/17081983/1830053 nucleus 21 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ANK3 HGNC:494 ankyrin 3, node of Ranvier (ankyrin G) Q12955 Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). Lysosome (By similarity). Note=In skeletal muscle, localized at costameres and neuromuscular junctions (By similarity). In macrophages, associated with lysosomes (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12507143,14694156,8666667 cytoplasm 18 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms ANKAR HGNC:26350 ankyrin and armadillo repeat containing Q7Z5J8 Membrane; Single-pass membrane protein (Potential). nucleus 18 1 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms ANKDD1A HGNC:28002 ankyrin repeat and death domain containing 1A Q495B1 cytoplasm 18 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms ANKDD1B HGNC:32525 ankyrin repeat and death domain containing 1B A6NHY2 nucleus 15 0 nucleus nucleus Euarchontoglires Euteleostomi Cell.Organisms ANKEF1 HGNC:15803 ankyrin repeat and EF-hand domain containing 1 Q9NU02 golgi apparatus 18 0 golgi apparatus golgi apparatus Deuterostomia Deuterostomia Cell.Organisms ANKFN1 HGNC:26766 ankyrin-repeat and fibronectin type III domain containing 1 Q8N957 nucleus 54 0 nucleus nucleus Bilateria Bilateria Holozoa ANKFY1 HGNC:20763 ankyrin repeat and FYVE domain containing 1 Q9P2R3 Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Also associated with endosomal membranes. Cytoplasm (GO:0005737); Endosome (GO:0005768) 10092534,10092534 nucleus 31 0 cytoplasm. endosome multiple Bilateria Bilateria Cell.Organisms ANKH HGNC:15492 ANKH inorganic pyrophosphate transport regulator Q9HCJ1 Membrane; Multi-pass membrane protein (Probable). Cell surface (GO:0009986); Nucleus (GO:0005634) 10894769,12297989,10894769 plasma membrane 54 9 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms ANKHD1 HGNC:24714 ankyrin repeat and KH domain containing 1 Q8IWZ3 Cytoplasm. Cytoplasm (GO:0005737) 16098192 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms ANKIB1 HGNC:22215 ankyrin repeat and IBR domain containing 1 Q9P2G1 cytoplasm 24 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms ANKK1 HGNC:21027 ankyrin repeat and kinase domain containing 1 Q8NFD2 cytoplasm 18 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms ANKLE1 HGNC:26812 ankyrin repeat and LEM domain containing 1 Q8NAG6 Nucleus (GO:0005634) cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms ANKLE2 HGNC:29101 ankyrin repeat and LEM domain containing 2 Q86XL3 Endoplasmic reticulum membrane; Single-pass type III membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Holozoa ANKMY1 HGNC:20987 ankyrin repeat and MYND domain containing 1 Q9P2S6 golgi apparatus 28 0 golgi apparatus golgi apparatus Deuterostomia Deuterostomia Cell.Organisms ANKMY2 HGNC:25370 ankyrin repeat and MYND domain containing 2 Q8IV38 Cell projection, cilium (By similarity). endoplasmic reticulum membrane 38 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Cell.Organisms ANKRA2 HGNC:13208 ankyrin repeat, family A (RFXANK-like), 2 Q9H9E1 Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11095640,11095640 nucleus 40 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms ANKRD1 HGNC:15819 ankyrin repeat domain 1 (cardiac muscle) Q15327 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 7730328,12054667,7730328,12054667,14583192 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms ANKRD10 HGNC:20265 ankyrin repeat domain 10 Q9NXR5 nucleus 19 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms ANKRD11 HGNC:21316 ankyrin repeat domain 11 Q6UB99 Nucleus. Nucleus (GO:0005634) 15184363,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms ANKRD12 HGNC:29135 ankyrin repeat domain 12 Q6UB98 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Chordata Bilateria Cell.Organisms ANKRD13A HGNC:21268 ankyrin repeat domain 13A Q8IZ07 golgi apparatus 26 0 golgi apparatus golgi apparatus Bilateria Eukaryota Cell.Organisms ANKRD13B HGNC:26363 ankyrin repeat domain 13B Q86YJ7 cytoplasm 33 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms ANKRD13C HGNC:25374 ankyrin repeat domain 13C Q8N6S4 Endoplasmic reticulum membrane. Note=Associated with the cytosolic side. plasma membrane 22 0 n/a n/a Bilateria Eukaryota Cell.Organisms ANKRD13D HGNC:27880 ankyrin repeat domain 13 family, member D Q6ZTN6 nucleus 62 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms ANKRD16 HGNC:23471 ankyrin repeat domain 16 Q6P6B7 mitochondrion 18 0 mitochondrion mitochondrion Chordata Cell.Organisms Cell.Organisms ANKRD17 HGNC:23575 ankyrin repeat domain 17 O75179 Cytoplasm. Nucleus. Note=Detected around the nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11165478,17081983,17081983 cytoplasm 55 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms ANKRD18A HGNC:23643 ankyrin repeat domain 18A Q8IVF6 nucleus 17 0 nucleus nucleus Catarrhini Catarrhini Cell.Organisms ANKRD18B HGNC:23644 ankyrin repeat domain 18B A2A2Z9 mitochondrion 14 0 mitochondrion mitochondrion NA NA Cell.Organisms ANKRD2 HGNC:495 ankyrin repeat domain 2 (stretch responsive muscle) Q9GZV1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11444853,15136035,12004005,12004005 nucleus 36 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Cell.Organisms ANKRD20A1 HGNC:23665 ankyrin repeat domain 20 family, member A1 Q5TYW2 nucleus 16 0 nucleus nucleus Catarrhini Eutheria Cell.Organisms ANKRD20A2 HGNC:31979 ankyrin repeat domain 20 family, member A2 Q5SQ80 nucleus 15 0 nucleus nucleus Catarrhini Eutheria Cell.Organisms ANKRD20A3 HGNC:31981 ankyrin repeat domain 20 family, member A3 Q5VUR7 nucleus 15 0 nucleus nucleus Catarrhini Eutheria Cell.Organisms ANKRD20A4 HGNC:31982 ankyrin repeat domain 20 family, member A4 Q4UJ75 cytoplasm 18 0 cytoplasm cytoplasm Catarrhini Eutheria Cell.Organisms ANKRD22 HGNC:28321 ankyrin repeat domain 22 Q5VYY1 cytoplasm 30 1 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms ANKRD23 HGNC:24470 ankyrin repeat domain 23 Q86SG2 Nucleus. Note=Sarcomeric I-band and some intercalated disks (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12456686,12456686 nucleus 100 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Cell.Organisms ANKRD24 HGNC:29424 ankyrin repeat domain 24 Q8TF21 mitochondrion 21 0 mitochondrion mitochondrion Amniota Chordata Cell.Organisms ANKRD26 HGNC:29186 ankyrin repeat domain 26 Q9UPS8 cytoplasm 12 0 cytoplasm cytoplasm Amniota Amniota Cell.Organisms ANKRD27 HGNC:25310 ankyrin repeat domain 27 (VPS9 domain) Q96NW4 Cytoplasm. Note=Mainly localized to early endosomes in the perinuclear region (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms ANKRD28 HGNC:29024 ankyrin repeat domain 28 O15084 Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli. nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms ANKRD29 HGNC:27110 ankyrin repeat domain 29 Q8N6D5 mitochondrion 21 0 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms ANKRD30A HGNC:17234 ankyrin repeat domain 30A Q9BXX3 Nucleus (GO:0005634) 11280766 nucleus 17 0 nucleus nucleus Catarrhini Catarrhini Cell.Organisms ANKRD30B HGNC:24165 ankyrin repeat domain 30B Q9BXX2 nucleus 18 0 nucleus nucleus Catarrhini Catarrhini Cell.Organisms ANKRD30BL HGNC:35167 ankyrin repeat domain 30B-like A7E2S9 cytoplasm 13 0 cytoplasm cytoplasm Homininae Homininae Cell.Organisms ANKRD31 HGNC:26853 ankyrin repeat domain 31 Q8N7Z5 nucleus 20 0 nucleus nucleus Amniota Amniota Cell.Organisms ANKRD32 HGNC:25408 ankyrin repeat domain 32 Q9BQI6 nucleus 27 1 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms ANKRD33 HGNC:13788 ankyrin repeat domain 33 Q7Z3H0 mitochondrion 36 1 mitochondrion mitochondrion Eutheria Euteleostomi Cell.Organisms ANKRD33B HGNC:35240 ankyrin repeat domain 33B A6NCL7 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms ANKRD34A HGNC:27639 ankyrin repeat domain 34A Q69YU3 cytoplasm 28 0 cytoplasm cytoplasm Theria Tetrapoda Metazoa ANKRD34B HGNC:33736 ankyrin repeat domain 34B A5PLL1 Cytoplasm. Nucleus (By similarity). Cytoplasm (GO:0005737) 15358210 cytoplasm 25 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms ANKRD34C HGNC:33888 ankyrin repeat domain 34C P0C6C1 cytoplasm 32 0 cytoplasm cytoplasm NA NA Cell.Organisms ANKRD35 HGNC:26323 ankyrin repeat domain 35 Q8N283 cytoplasm 15 0 cytoplasm cytoplasm Mammalia Tetrapoda NA ANKRD36 HGNC:24079 ankyrin repeat domain 36 A6QL64 cytoplasm 14 0 cytoplasm cytoplasm NA NA Cell.Organisms ANKRD36B HGNC:29333 ankyrin repeat domain 36B Q8N2N9 cytoplasm 17 0 cytoplasm cytoplasm Homininae Homininae NA ANKRD36C HGNC:32946 ankyrin repeat domain 36C Q5JPF3 mitochondrion 16 0 mitochondrion mitochondrion NA NA Cell.Organisms ANKRD37 HGNC:29593 ankyrin repeat domain 37 Q7Z713 Nucleus. Cytoplasm. Plasma membrane (GO:0005886) cytoplasm 27 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms ANKRD39 HGNC:28640 ankyrin repeat domain 39 Q53RE8 cytoplasm 19 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms ANKRD40 HGNC:28233 ankyrin repeat domain 40 Q6AI12 nucleus 30 0 nucleus nucleus Tetrapoda Deuterostomia Cell.Organisms ANKRD42 HGNC:26752 ankyrin repeat domain 42 Q8N9B4 nucleus 14 0 nucleus nucleus Amniota Eukaryota Cell.Organisms ANKRD44 HGNC:25259 ankyrin repeat domain 44 Q8N8A2 Plasma membrane (GO:0005886) 16555005 nucleus 64 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms ANKRD45 HGNC:24786 ankyrin repeat domain 45 Q5TZF3 endoplasmic reticulum 21 0 endoplasmic reticulum endoplasmic reticulum Theria Deuterostomia Cell.Organisms ANKRD46 HGNC:27229 ankyrin repeat domain 46 Q86W74 Membrane; Single-pass membrane protein (Potential). cytoplasm 26 1 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms ANKRD49 HGNC:25970 ankyrin repeat domain 49 Q8WVL7 nucleus 21 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms ANKRD50 HGNC:29223 ankyrin repeat domain 50 Q9ULJ7 cytoplasm 23 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms ANKRD52 HGNC:26614 ankyrin repeat domain 52 Q8NB46 nucleus 54 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms ANKRD53 HGNC:25691 ankyrin repeat domain 53 Q8N9V6 cytoplasm 13 0 cytoplasm cytoplasm Eutheria Eutheria NA ANKRD54 HGNC:25185 ankyrin repeat domain 54 Q6NXT1 Nucleus (By similarity). Cytoplasm (By similarity). Midbody (By similarity). Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 21 0 nucleus nucleus Amniota Bilateria Cell.Organisms ANKRD55 HGNC:25681 ankyrin repeat domain 55 Q3KP44 peroxisome 16 0 peroxisome peroxisome Mammalia Deuterostomia Cell.Organisms ANKRD6 HGNC:17280 ankyrin repeat domain 6 Q9Y2G4 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms ANKRD60 HGNC:16217 ankyrin repeat domain 60 Q9BZ19 endoplasmic reticulum membrane 41 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Deuterostomia Cell.Organisms ANKRD61 HGNC:22467 ankyrin repeat domain 61 A6NGH8 mitochondrion 16 0 mitochondrion mitochondrion Mammalia Mammalia Cell.Organisms ANKRD62 HGNC:35241 ankyrin repeat domain 62 A6NC57 cytoplasm 15 0 cytoplasm cytoplasm Human Catarrhini Cell.Organisms ANKRD63 HGNC:40027 ankyrin repeat domain 63 C9JTQ0 cytoplasm 18 0 cytoplasm cytoplasm NA NA Cell.Organisms ANKRD65 HGNC:42950 ankyrin repeat domain 65 E5RJM6 cytoplasm 22 0 cytoplasm cytoplasm NA NA Cell.Organisms ANKRD66 HGNC:44669 ankyrin repeat domain 66 B4E2M5 nucleus 15 0 nucleus nucleus NA NA Cell.Organisms ANKRD7 HGNC:18588 ankyrin repeat domain 7 Q92527 mitochondrion 20 0 mitochondrion mitochondrion Deuterostomia Eukaryota Cell.Organisms ANKRD9 HGNC:20096 ankyrin repeat domain 9 Q96BM1 nucleus 36 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria ANKS1A HGNC:20961 ankyrin repeat and sterile alpha motif domain containing 1A Q92625 Cytoplasm. Cell projection (By similarity). Note=Cytoplasmic before and after growth factor treatment. Cytoplasm (GO:0005737) 12439753,15500253 mitochondrion 25 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Cell.Organisms ANKS1B HGNC:24600 ankyrin repeat and sterile alpha motif domain containing 1B Q7Z6G8 Cytoplasm. Isoform 2: Nucleus. Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Isoform 4: Nucleus. Isoform 6: Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15862129,15862129 cytoplasm 25 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms ANKS3 HGNC:29422 ankyrin repeat and sterile alpha motif domain containing 3 Q6ZW76 Nucleus (GO:0005634) cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms ANKS4B HGNC:26795 ankyrin repeat and sterile alpha motif domain containing 4B Q8N8V4 mitochondrion 22 0 mitochondrion mitochondrion Amniota Euteleostomi Cell.Organisms ANKS6 HGNC:26724 ankyrin repeat and sterile alpha motif domain containing 6 Q68DC2 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms ANKUB1 HGNC:29642 ankyrin repeat and ubiquitin domain containing 1 A6NFN9 nucleus 20 0 nucleus nucleus Mammalia Deuterostomia Eumetazoa ANKZF1 HGNC:25527 ankyrin repeat and zinc finger domain containing 1 Q9H8Y5 Cytoplasm (GO:0005737) 17081983 cytoplasm 27 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota ANLN HGNC:14082 anillin, actin binding protein Q9NQW6 Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Cytoplasm (GO:0005737) 10931866,15635413,15561729,17081983 cytoplasm 66 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa ANO1 HGNC:21625 anoctamin 1, calcium activated chloride channel Q5XXA6 Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNS) tumors. Integral to membrane (GO:0016021) 12739008 plasma membrane 55 8 cytoplasm. plasma membrane multiple Deuterostomia Eukaryota Eukaryota ANO10 HGNC:25519 anoctamin 10 Q9NW15 Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. plasma membrane 100 10 plasma membrane plasma membrane Opisthokonta Eukaryota Eukaryota ANO2 HGNC:1183 anoctamin 2 Q9NQ90 Cell membrane; Multi-pass membrane protein. plasma membrane 100 8 plasma membrane plasma membrane Deuterostomia Eukaryota Eukaryota ANO3 HGNC:14004 anoctamin 3 Q9BYT9 Cell membrane; Multi-pass membrane protein (Potential). Note=Shows an intracellular localization (By similarity). Integral to membrane (GO:0016021) 12739008 plasma membrane 62 8 plasma membrane plasma membrane Deuterostomia Eukaryota Eukaryota ANO4 HGNC:23837 anoctamin 4 Q32M45 Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization (By similarity). Integral to membrane (GO:0016021) 12739008 plasma membrane 100 8 plasma membrane plasma membrane Deuterostomia Eukaryota NA ANO5 HGNC:27337 anoctamin 5 Q75V66 Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane. Note=Co-localized with CALR/calreticulin. Shows an intracellular localization according to PubMed:22075693. Endoplasmic reticulum (GO:0005783) 15124103 plasma membrane 40 8 endoplasmic reticulum. endoplasmic reticulum membrane multiple Deuterostomia Eukaryota Eukaryota ANO6 HGNC:25240 anoctamin 6 Q4KMQ2 Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693. Integral to membrane (GO:0016021) 15067359 plasma membrane 100 8 plasma membrane plasma membrane Deuterostomia Eukaryota Eukaryota ANO7 HGNC:31677 anoctamin 7 Q6IWH7 Isoform 1: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum. Isoform 2: Cytoplasm, cytosol. Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 14981236/14981236 plasma membrane 26 8 cytoplasm. endoplasmic reticulum. plasma membrane multiple Theria Bilateria Eukaryota ANO8 HGNC:29329 anoctamin 8 Q9HCE9 Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. plasma membrane 100 8 plasma membrane plasma membrane Bilateria Bilateria Eukaryota ANO9 HGNC:20679 anoctamin 9 A1A5B4 Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Eutheria Euteleostomi Eukaryota ANP32A HGNC:13233 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A P39687 Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 8192856,11565755,8970164,17245428 nucleus 59 0 cytoplasm. endoplasmic reticulum. nucleus multiple Chordata Chordata Eukaryota ANP32B HGNC:16677 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Q92688 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Note=Lacks a nuclear localization signal. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 9285060,11565755,9285060,11565755 nucleus 84 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ANP32D HGNC:16676 acidic (leucine-rich) nuclear phosphoprotein 32 family, member D O95626 Nucleus (GO:0005634) nucleus 64 0 nucleus nucleus Human Human Eukaryota ANP32E HGNC:16673 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E Q9BTT0 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 59 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota ANPEP HGNC:500 alanyl (membrane) aminopeptidase P15144 Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol (Potential). Note=A soluble form has also been detected. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 2901990,12473585 plasma membrane 58 1 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms ANTXR1 HGNC:21014 anthrax toxin receptor 1 Q9H6X2 Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single- pass type I membrane protein. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia. Plasma membrane (GO:0005886);Nucleus (GO:0005634) 11700562/17081983 nucleus 33 1 nucleus. plasma membrane multiple Deuterostomia Deuterostomia Cell.Organisms ANTXR2 HGNC:21732 anthrax toxin receptor 2 P58335 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11683410,16564009 secreted 12 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms ANTXRL HGNC:27277 anthrax toxin receptor-like A6NF34 Membrane; Single-pass type I membrane protein (Potential). secreted 19 1 secreted secreted Eutheria Eutheria Cell.Organisms ANXA1 HGNC:533 annexin A1 P04083 Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 12679902,12679902,12679902,15598749 cytoplasm 28 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Eukaryota ANXA10 HGNC:534 annexin A10 Q9UJ72 cytoplasm 21 0 cytoplasm cytoplasm Amniota Amniota Eukaryota ANXA11 HGNC:535 annexin A11 P50995 Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell- cycle dependent. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7508441,12805373,7508441 cytoplasm 35 0 cytoplasm. melanosome. nucleus multiple Bilateria Eukaryota Eukaryota ANXA13 HGNC:536 annexin A13 P27216 Cell membrane. Note=Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 1530946,14718574 cytoplasm 89 0 secreted secreted Deuterostomia Eukaryota Eukaryota ANXA2 HGNC:537 annexin A2 P07355 Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endosome (GO:0005768); Extracellular (GO:0005576); Nucleolus (GO:0005730); Apical membrane (GO:0016327); Cytoskeleton (GO:0005856) 11106497,15211578,8834809,8521818,14699089,12629510,12045186,8834809,15211578,11108961,7518469,15635413,11790298,17254974,15561729 cytoplasm 29 0 cytoplasm. endosome. melanosome. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota ANXA2R HGNC:33463 annexin A2 receptor Q3ZCQ2 secreted 83 1 secreted secreted Catarrhini Euarchontoglires Euarchontoglires ANXA3 HGNC:541 annexin A3 P12429 Cytoplasm (GO:0005737) 1830024 cytoplasm 29 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota ANXA4 HGNC:542 annexin A4 P09525 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10883672,10978337,10978337,10949146 cytoplasm 34 0 cytoplasm. golgi apparatus. nucleus multiple Theria Eukaryota Eukaryota ANXA5 HGNC:543 annexin A5 P08758 Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 1397263,8834809,8834809,8495746,8495746 cytoplasm 31 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota ANXA6 HGNC:544 annexin A6 P08133 Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 8834809,8834809,1831222,1831222,15598749 cytoplasm 32 0 cytoplasm. endoplasmic reticulum. melanosome. mitochondrion multiple Euteleostomi Euteleostomi Eukaryota ANXA7 HGNC:545 annexin A7 P20073 Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737) 11338180,7738119,7738119,10672515,7738119,7738119,7738119,10672515 cytoplasm 38 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Eukaryota ANXA8 HGNC:546 annexin A8 P13928 cytoplasm 36 0 cytoplasm cytoplasm Amniota Amniota NA ANXA8L1 HGNC:23334 annexin A8-like 1 Q5T2P8 cytoplasm 36 0 cytoplasm cytoplasm Amniota Amniota Eukaryota ANXA8L2 HGNC:23335 annexin A8-like 2 Q5VT79 Plasma membrane (GO:0005886) 8018923 cytoplasm 36 0 cytoplasm cytoplasm Amniota Amniota Eukaryota ANXA9 HGNC:547 annexin A9 O76027 Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654) 12832069,12832069 cytoplasm 17 0 cytoplasm. nucleus multiple Theria Theria Eukaryota AOAH HGNC:548 acyloxyacyl hydrolase (neutrophil) P28039 Secreted. Lysosome (GO:0005764); Extracellular (GO:0005576) 8089145,8613354 secreted 100 0 lysosome. secreted multiple Deuterostomia Eukaryota Eukaryota AOC1 HGNC:80 amine oxidase, copper containing 1 P19801 Secreted, extracellular space. Extracellular (GO:0005576) 11855874 secreted 100 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms AOC2 HGNC:549 amine oxidase, copper containing 2 (retina-specific) O75106 Isoform 1: Cell membrane; Peripheral membrane protein. Isoform 2: Cytoplasm. Note=Either not translocated to the plasma membrane or below detection level. Integral to membrane (GO:0016021) 14585497 secreted 55 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms AOC3 HGNC:550 amine oxidase, copper containing 3 Q16853 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 9653080 secreted 79 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms AOX1 HGNC:553 aldehyde oxidase 1 Q06278 Cytoplasm. Cytoplasm (GO:0005737) 8043023 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms AP1AR HGNC:28808 adaptor-related protein complex 1 associated regulatory protein Q63HQ0 Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery. nucleus 64 0 endosome. golgi apparatus multiple Tetrapoda Euteleostomi Bilateria AP1B1 HGNC:554 adaptor-related protein complex 1, beta 1 subunit Q10567 Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Golgi apparatus (GO:0005794) 10966473 golgi apparatus 15 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota AP1G1 HGNC:555 adaptor-related protein complex 1, gamma 1 subunit O43747 Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Cytosol (GO:0005829); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 9733768,9733768,9733768 golgi apparatus 13 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP1G2 HGNC:556 adaptor-related protein complex 1, gamma 2 subunit O75843 Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures. Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures. Perinuclear region (GO:0048471); Cytosol (GO:0005829); Golgi apparatus (GO:0005794) 9762922,9733768,9762922 golgi apparatus 10 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP1M1 HGNC:13667 adaptor-related protein complex 1, mu 1 subunit Q9BXS5 Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 8810314,8810314,11157985,11157985 golgi apparatus 12 0 cytoplasm. endosome. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP1M2 HGNC:558 adaptor-related protein complex 1, mu 2 subunit Q9Y6Q5 Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 8810314,9714795 golgi apparatus 15 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP1S1 HGNC:559 adaptor-related protein complex 1, sigma 1 subunit P61966 Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Golgi apparatus (GO:0005794) 10966473 nucleus 18 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota AP1S2 HGNC:560 adaptor-related protein complex 1, sigma 2 subunit P56377 Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Golgi apparatus (GO:0005794) 10966473 nucleus 18 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota AP1S3 HGNC:18971 adaptor-related protein complex 1, sigma 3 subunit Q96PC3 Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) , nucleus 35 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota AP2A1 HGNC:561 adaptor-related protein complex 2, alpha 1 subunit O95782 Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=AP-2 appears to be excluded from internalizing Vs and to disengage from sites of endocytosis seconds before internalization of the nascent V (By similarity). Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 10966473,15598749 golgi apparatus 10 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota AP2A2 HGNC:562 adaptor-related protein complex 2, alpha 2 subunit O94973 Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=AP-2 appears to be excluded from internalizing Vs and to disengage from sites of endocytosis seconds before internalization of the nascent V (By similarity). Plasma membrane (GO:0005886) 10966473 golgi apparatus 9 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota AP2B1 HGNC:563 adaptor-related protein complex 2, beta 1 subunit P63010 Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing Vs and to disengage from sites of endocytosis seconds before internalization of the nascent V. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 14530274,15598749 golgi apparatus 13 0 mitochondrion mitochondrion Eukaryota Eukaryota NA AP2M1 HGNC:564 adaptor-related protein complex 2, mu 1 subunit Q96CW1 Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing Vs and to disengage from sites of endocytosis seconds before internalization of the nascent V (By similarity). Plasma membrane (GO:0005886) 8491205,9571248,15911768 golgi apparatus 11 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota AP2S1 HGNC:565 adaptor-related protein complex 2, sigma 1 subunit P53680 Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing Vs and to disengage from sites of endocytosis seconds before internalization of the nascent V (By similarity). Plasma membrane (GO:0005886) 2040623,2495531 nucleus 44 0 nucleus nucleus Theria Eukaryota Eukaryota AP3B1 HGNC:566 adaptor-related protein complex 3, beta 1 subunit O00203 Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9182526,9182526/17081983,17081983 nucleus 21 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota AP3B2 HGNC:567 adaptor-related protein complex 3, beta 2 subunit Q13367 Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity). Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023) 7671305,7671305 nucleus 34 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP3D1 HGNC:568 adaptor-related protein complex 3, delta 1 subunit O14617 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 17081983/9151686,9151686 nucleus 14 2 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP3M1 HGNC:569 adaptor-related protein complex 3, mu 1 subunit Q9Y2T2 Golgi apparatus. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Lysosome (GO:0005764) 11071902,10024875,10024875 golgi apparatus 100 0 cytoplasm. golgi apparatus. lysosome multiple Bilateria Eukaryota Eukaryota AP3M2 HGNC:570 adaptor-related protein complex 3, mu 2 subunit P53677 Golgi apparatus. Golgi apparatus (GO:0005794) golgi apparatus 100 0 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota AP3S1 HGNC:2013 adaptor-related protein complex 3, sigma 1 subunit Q92572 Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 9118953,9151686 nucleus 41 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP3S2 HGNC:571 adaptor-related protein complex 3, sigma 2 subunit P59780 Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity). Endosome (GO:0005768) 12967569 nucleus 49 0 endosome. golgi apparatus multiple Eukaryota Eukaryota Eukaryota AP4B1 HGNC:572 adaptor-related protein complex 4, beta 1 subunit Q9Y6B7 Golgi apparatus, trans-Golgi network. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. Golgi apparatus (GO:0005794) 10066790 golgi apparatus 100 0 golgi apparatus golgi apparatus Euteleostomi Eukaryota Eukaryota AP4E1 HGNC:573 adaptor-related protein complex 4, epsilon 1 subunit Q9UPM8 Golgi apparatus, trans-Golgi network. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. Golgi apparatus (GO:0005794) 10066790 golgi apparatus 100 0 golgi apparatus golgi apparatus Chordata Eukaryota Eukaryota AP4M1 HGNC:574 adaptor-related protein complex 4, mu 1 subunit O00189 Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Dendrite (GO:0030425) 10066790,14572453,14572453,14572453 golgi apparatus 7 0 cytoplasm. golgi apparatus multiple NA NA Eukaryota AP4S1 HGNC:575 adaptor-related protein complex 4, sigma 1 subunit Q9Y587 Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. Golgi apparatus (GO:0005794) 10066790 nucleus 40 0 golgi apparatus golgi apparatus Euteleostomi Eukaryota Eukaryota AP5B1 HGNC:25104 adaptor-related protein complex 5, beta 1 subunit Q2VPB7 secreted 82 0 secreted secreted NA NA Holozoa AP5M1 HGNC:20192 adaptor-related protein complex 5, mu 1 subunit Q9H0R1 Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=May cycle on and off membranes. mitochondrion 12 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota AP5S1 HGNC:15875 adaptor-related protein complex 5, sigma 1 subunit Q9NUS5 Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). nucleus 20 1 cytoplasm cytoplasm Theria Eukaryota Metazoa AP5Z1 HGNC:22197 adaptor-related protein complex 5, zeta 1 subunit O43299 Cytoplasm. Nucleus. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic (PubMed:20613862). secreted 50 0 cytoplasm. nucleus multiple NA NA Eukaryota APAF1 HGNC:576 apoptotic peptidase activating factor 1 O14727 Cytoplasm. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794);Nucleus (GO:0005634) 9267021,11457460/17081983 cytoplasm 100 0 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms APBA1 HGNC:578 amyloid beta (A4) precursor protein-binding, family A, member 1 Q02410 Nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11010978,9952408,9395480,9952408 nucleus 100 3 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Holozoa APBA2 HGNC:579 amyloid beta (A4) precursor protein-binding, family A, member 2 Q99767 Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9890987,9890987,9890987 nucleus 79 3 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Bilateria Bilateria Holozoa APBA3 HGNC:580 amyloid beta (A4) precursor protein-binding, family A, member 3 O96018 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 11440799,11440799,11440799 cytoplasm 100 0 cytoplasm. golgi apparatus multiple Theria Amniota Holozoa APBB1 HGNC:581 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) O00213 Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone (By similarity). Nucleus speckle. Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Co-localizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cell projection (GO:0042995); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endosome (GO:0005768) 12150997,11085987,11085987,12843239,10075692,10075692,10075692,10075692 cytoplasm 34 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus multiple Theria Euteleostomi Holozoa APBB1IP HGNC:17379 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein Q7Z5R6 Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 14530287,15469846 cytoplasm 31 0 cytoplasm cytoplasm Human Euteleostomi Opisthokonta APBB2 HGNC:582 amyloid beta (A4) precursor protein-binding, family B, member 2 Q92870 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12089154,12089154 cytoplasm 34 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa APBB3 HGNC:20708 amyloid beta (A4) precursor protein-binding, family B, member 3 O95704 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12153398,12153398 nucleus 41 0 cytoplasm. nucleus multiple Amniota Euteleostomi Metazoa APC HGNC:583 adenomatous polyposis coli P25054 Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11241666,11157977,15020226,17081983,11241666,11157977,17081983,11157977,15020226 nucleus 18 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota APC2 HGNC:24036 adenomatosis polyposis coli 2 O95996 Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with actin filaments and the microtubule network. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Actin cytoskeleton (GO:0015629) 11691822,11691822,10021369,11691822,11691822 nucleus 19 0 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Bilateria Eukaryota APCDD1 HGNC:15718 adenomatosis polyposis coli down-regulated 1 Q8J025 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Opisthokonta APCDD1L HGNC:26892 adenomatosis polyposis coli down-regulated 1-like Q8NCL9 Membrane; Single-pass membrane protein (Potential). plasma membrane 40 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa APCS HGNC:584 amyloid P component, serum P02743 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12767937,16188874,14519527,14519527 secreted 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms APEH HGNC:586 acylaminoacyl-peptide hydrolase P13798 Cytoplasm. Cytoplasm (GO:0005737) 10719179 cytoplasm 100 1 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms APELA HGNC:48925 apelin receptor early endogenous ligand P0DMC3 Secreted, extracellular space (By similarity). Secreted. secreted 41 0 secreted secreted NA NA NA APEX1 HGNC:587 APEX nuclease (multifunctional DNA repair enzyme) 1 P27695 Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion. Note=The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 12524539,11182545,9870152,12524539,11182545,9870152,14521941,12524539,12384995,11182545,15598749,15635413 nucleus 39 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms APEX2 HGNC:17889 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 Q9UBZ4 Nucleus. Cytoplasm. Mitochondrion (Probable). Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11376153,11376153 nucleus 29 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Eukaryota Cell.Organisms APH1A HGNC:29509 APH1A gamma secretase subunit Q96BI3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Vesicle (None); Perinuclear region (GO:0048471) 14572442,12471034,12471034,12471034,12471034,12471034 endoplasmic reticulum membrane 47 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota NA APH1B HGNC:24080 APH1B gamma secretase subunit Q8WW43 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 42 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Eutheria Eukaryota API5 HGNC:594 apoptosis inhibitor 5 Q9BZZ5 Nucleus. Cytoplasm. Isoform 3: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11075807,11075807,15635413 nucleus 79 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota APIP HGNC:17581 APAF1 interacting protein Q96GX9 Cytoplasm. Cytoplasm (GO:0005737) 15262985 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms APITD1 HGNC:23163 apoptosis-inducing, TAF9-like domain 1 Q8N2Z9 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota APLF HGNC:28724 aprataxin and PNKP like factor Q8IW19 Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers. Nucleus (GO:0005634) 17396150 nucleus 84 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Holozoa APLN HGNC:16665 apelin Q9ULZ1 Secreted. Extracellular (GO:0005576) 12914775 secreted 100 0 secreted secreted Theria Theria Mammalia APLNR HGNC:339 apelin receptor P35414 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8971794 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa APLP1 HGNC:597 amyloid beta (A4) precursor-like protein 1 P51693 Cell membrane; Single-pass type I membrane protein. C30: Cytoplasm. Note=C-terminally processed in the Golgi complex. Endoplasmic reticulum (GO:0005783);Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471) /10460257,9428684,10460257,9428684,10460257,9428684,10460257,9428684 secreted 28 1 cytoplasm. endoplasmic reticulum. golgi apparatus. plasma membrane. secreted multiple Euteleostomi Deuterostomia Eumetazoa APLP2 HGNC:598 amyloid beta (A4) precursor-like protein 2 Q06481 Cell membrane; Single-pass type I membrane protein (Potential). Nucleus (Potential). Plasma membrane (GO:0005886) 12499552,9556595 secreted 39 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms APMAP HGNC:13238 adipocyte plasma membrane associated protein Q9HDC9 Membrane; Single-pass type II membrane protein. secreted 15 1 secreted secreted Bilateria Cell.Organisms Cell.Organisms APOA1 HGNC:600 apolipoprotein A-I P02647 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 3005308,3119665,10801839,16188874,8740847,11878923 secreted 100 0 cytoplasm. golgi apparatus. secreted multiple Tetrapoda Tetrapoda Craniata APOA1BP HGNC:18453 apolipoprotein A-I binding protein Q8NCW5 Mitochondrion (By similarity). Secreted. Note=In sperm, secretion gradually increases during capacitation (By similarity). Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 11991719,11991719 mitochondrion 42 0 endoplasmic reticulum. secreted multiple Eukaryota Eukaryota Cell.Organisms APOA2 HGNC:601 apolipoprotein A-II P02652 Secreted. Extracellular (GO:0005576) 1908160,16188874 secreted 100 0 secreted secreted Theria Theria Mammalia APOA4 HGNC:602 apolipoprotein A-IV P06727 Secreted. Extracellular (GO:0005576) 6987270,16188874 secreted 100 0 secreted secreted NA NA Cell.Organisms APOA5 HGNC:17288 apolipoprotein A-V Q6Q788 Secreted. Extracellular (GO:0005576) 11577099 secreted 100 0 secreted secreted Theria Amniota Euteleostomi APOB HGNC:603 apolipoprotein B P04114 Cytoplasm. Secreted. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 3346254,9252351,12397072,9252351,6099394,9252351 secreted 20 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms APOBEC1 HGNC:604 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 P41238 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12881431,11577082,14559896,12881431,11577082 cytoplasm 100 1 cytoplasm. nucleus multiple Theria Theria Craniata APOBEC2 HGNC:605 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 Q9Y235 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11698249,11698249 cytoplasm 18 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata APOBEC3A HGNC:17343 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A P31941 Nucleus. Cytoplasm. Cytoplasm (GO:0005737) 10469298 nucleus 88 0 cytoplasm. nucleus multiple Homininae Eutheria NA APOBEC3B HGNC:17352 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B Q9UH17 Nucleus. Nucleus (GO:0005634) 15561729 nucleus 100 0 nucleus nucleus Eutheria Eutheria Craniata APOBEC3C HGNC:17353 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C Q9NRW3 Nucleus. Cytoplasm. cytoplasm 74 0 cytoplasm. nucleus multiple NA NA Craniata APOBEC3D HGNC:17354 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Q96AK3 Cytoplasm. Cytoplasm, P-body. cytoplasm 100 0 cytoplasm cytoplasm NA NA Craniata APOBEC3F HGNC:17356 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F Q8IUX4 Cytoplasm. Cytoplasm, P-body. cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Catarrhini Craniata APOBEC3G HGNC:17357 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Q9HC16 Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF. Nucleus (GO:0005634) 12167863 nucleus 47 0 cytoplasm. nucleus multiple NA NA Craniata APOBEC3H HGNC:24100 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H Q6NTF7 Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic. cytoplasm 77 0 cytoplasm. nucleus multiple Catarrhini Eutheria Craniata APOBEC4 HGNC:32152 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) Q8WW27 nucleus 32 0 nucleus nucleus Euarchontoglires Tetrapoda Craniata APOBR HGNC:24087 apolipoprotein B receptor Q0VD83 Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein. cytoplasm 68 0 cytoplasm cytoplasm Eutheria Eutheria Boreoeutheria APOC1 HGNC:607 apolipoprotein C-I P02654 Secreted. Extracellular (GO:0005576) 10978346,7471419 secreted 100 0 secreted secreted Theria Theria Mammalia APOC2 HGNC:609 apolipoprotein C-II P02655 Secreted. Extracellular (GO:0005576) 3525527,16188874 secreted 100 0 secreted secreted NA NA Mammalia APOC3 HGNC:610 apolipoprotein C-III P02656 Secreted. Extracellular (GO:0005576) 3095836,16188874 secreted 100 0 secreted secreted Theria Theria Eutheria APOC4 HGNC:611 apolipoprotein C-IV P55056 Secreted. secreted 100 0 secreted secreted NA NA NA APOD HGNC:612 apolipoprotein D P05090 Secreted. Extracellular (GO:0005576) 11744388,16188874 secreted 100 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms APOE HGNC:613 apolipoprotein E P02649 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 7761390,2498325,16199891,16188874 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Euteleostomi APOF HGNC:615 apolipoprotein F Q13790 Secreted. Extracellular (GO:0005576) 6816269,16188874 secreted 100 0 secreted secreted Euarchontoglires Eutheria Euteleostomi APOH HGNC:616 apolipoprotein H (beta-2-glycoprotein I) P02749 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8139027,6403535,1748314,16199891,8139027,9352386 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Euteleostomi Holozoa APOL1 HGNC:618 apolipoprotein L, 1 O14791 Secreted. Extracellular (GO:0005576) 9325276,16188874 secreted 100 3 secreted secreted Human Human Amniota APOL2 HGNC:619 apolipoprotein L, 2 Q9BQE5 Cytoplasm (Probable). secreted 52 3 cytoplasm cytoplasm Euarchontoglires Euarchontoglires Amniota APOL3 HGNC:14868 apolipoprotein L, 3 O95236 Cytoplasm (Probable). Cytoplasm (GO:0005737); Extracellular (GO:0005576) 11290834,10233894 secreted 36 4 cytoplasm. secreted multiple Euteleostomi Euteleostomi Eumetazoa APOL4 HGNC:14867 apolipoprotein L, 4 Q9BPW4 Secreted (Potential). secreted 29 2 n/a n/a Human Catarrhini Eumetazoa APOL5 HGNC:14869 apolipoprotein L, 5 Q9BWW9 Cytoplasm (Probable). secreted 18 3 cytoplasm cytoplasm Homininae Eutheria Amniota APOL6 HGNC:14870 apolipoprotein L, 6 Q9BWW8 Cytoplasm (Probable). Cytoplasm (GO:0005737) secreted 26 3 cytoplasm cytoplasm NA NA Amniota APOLD1 HGNC:25268 apolipoprotein L domain containing 1 Q96LR9 Cell membrane; Multi-pass membrane protein (Probable). cytoplasm 7 3 plasma membrane plasma membrane Tetrapoda Tetrapoda Tetrapoda APOM HGNC:13916 apolipoprotein M O95445 Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL). Extracellular (GO:0005576); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 11944906,12666989,10531326,10531326 secreted 100 0 endoplasmic reticulum. secreted multiple Mammalia Tetrapoda NA APOO HGNC:28727 apolipoprotein O Q9BUR5 Membrane; Single-pass membrane protein (Potential). Secreted. Mitochondrion (GO:0005739) 15598749 mitochondrion membrane 61 1 mitochondrion. secreted multiple Tetrapoda Euteleostomi Chordata APOOL HGNC:24009 apolipoprotein O-like Q6UXV4 Secreted (Potential). Nucleus (GO:0005634) 17081983 mitochondrion membrane 41 2 nucleus nucleus Bilateria Bilateria Bilateria APOPT1 HGNC:20492 apoptogenic 1, mitochondrial Q96IL0 Mitochondrion (By similarity). mitochondrion 70 0 mitochondrion mitochondrion NA NA Opisthokonta APP HGNC:620 amyloid beta (A4) precursor protein P05067 Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Plasma membrane (GO:0005886);Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Nucleus (GO:0005634);Nucleus (GO:0005634); Integral to membrane (GO:0016021); Cell surface (GO:0009986); Vesicle (None) 16554819/10075692,11378243,10075692,11423558,15197182,10075692,15197182,14722157,12080182,15073156,15197182,7556457,14722157/12032152,16049941,12080182,7593229,12805363,17332754 secreted 39 1 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus. plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms APPBP2 HGNC:622 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 Q92624 Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein (Potential). Note=Associated with membranes and microtubules. Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794) 9843960,14729952,9843960,9843960 cytoplasm 30 0 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Bilateria Cell.Organisms APPL1 HGNC:24035 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Q9UKG1 Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. Cytoplasm (GO:0005737) 1043153 cytoplasm 11 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota APPL2 HGNC:18242 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 Q8NEU8 Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. Endosome (GO:0005768) 15016378 cytoplasm 12 0 endosome. nucleus multiple Deuterostomia Deuterostomia Eukaryota APRT HGNC:626 adenine phosphoribosyltransferase P07741 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms APTX HGNC:15984 aprataxin Q7Z2E3 Nucleus, nucleoplasm. Nucleus, nucleolus. Isoform 12: Cytoplasm. Nucleoplasm (GO:0005654); Nucleolus (GO:0005730) 15044383,15044383 nucleus 27 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms AQP1 HGNC:633 aquaporin 1 (Colton blood group) P29972 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 3049610,14592814,7517546,12002613 plasma membrane 32 6 plasma membrane plasma membrane NA NA Cell.Organisms AQP10 HGNC:16029 aquaporin 10 Q96PS8 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11573934 plasma membrane 39 6 plasma membrane plasma membrane Opisthokonta Cell.Organisms Cell.Organisms AQP11 HGNC:19940 aquaporin 11 Q8NBQ7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 79 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Deuterostomia Bilateria AQP12A HGNC:19941 aquaporin 12A Q8IXF9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 15 5 vacuole membrane vacuole membrane Theria Bilateria Eukaryota AQP12B HGNC:6096 aquaporin 12B A6NM10 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 15 5 vacuole membrane vacuole membrane Theria Bilateria Eukaryota AQP2 HGNC:634 aquaporin 2 (collecting duct) P41181 Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 7510718,10372737,10372737,11297561 plasma membrane 25 6 cytoplasm. endoplasmic reticulum. golgi apparatus membrane. plasma membrane multiple Euarchontoglires Eukaryota Cell.Organisms AQP3 HGNC:636 aquaporin 3 (Gill blood group) Q92482 Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney. Plasma membrane (GO:0005886) 9525951,12239222 plasma membrane 100 6 plasma membrane plasma membrane Opisthokonta Cell.Organisms Cell.Organisms AQP4 HGNC:637 aquaporin 4 P55087 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Golgi apparatus (GO:0005794) 11245621,11742978,8617713 plasma membrane 28 6 golgi apparatus. lysosome. plasma membrane multiple Euteleostomi Cell.Organisms Cell.Organisms AQP5 HGNC:638 aquaporin 5 P55064 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 11773623,12801959,10476940 vacuole membrane 23 6 plasma membrane plasma membrane Theria Cell.Organisms Cell.Organisms AQP6 HGNC:639 aquaporin 6, kidney specific Q13520 Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 12177001,10318966 vacuole membrane 23 6 plasma membrane plasma membrane Human Eutheria Cell.Organisms AQP7 HGNC:640 aquaporin 7 O14520 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9824541,9931374,9931374 plasma membrane 71 6 cytoplasm. golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms AQP8 HGNC:642 aquaporin 8 O94778 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12712100,11717661 vacuole membrane 22 6 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms AQP9 HGNC:643 aquaporin 9 O43315 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9514918 plasma membrane 35 6 plasma membrane plasma membrane Opisthokonta Cell.Organisms Cell.Organisms AQR HGNC:29513 aquarius intron-binding spliceosomal factor O60306 Nucleus. Note=Localizes to speckle-like regions of the nucleoplasm. Nucleus (GO:0005634) 9626505 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms AR HGNC:644 androgen receptor P10275 Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11396657,11795379,14729952,12805653,17183365,17392787,12944908,14517289,15178691,15062556,15027889,15361837,15305378,15288768,15466214,15661808,15525515,11396657,11795379,14729952,12805653,15107424,17183365,15288768,15305378,15288768/11396657,11795379,11795379,11916967 nucleus 43 1 cytoplasm. nucleus. plasma membrane multiple Eutheria Euteleostomi Metazoa ARAF HGNC:646 v-raf murine sarcoma 3611 viral oncogene homolog P10398 Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10848612,8020955,14684750,17081983,17081983 cytoplasm 12 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms ARAP1 HGNC:16925 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Q96P48 Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading. Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11804590,17081983,17081983 cytoplasm 28 0 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Deuterostomia Eukaryota ARAP2 HGNC:16924 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 Q8WZ64 Cytoplasm (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 26 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota ARAP3 HGNC:24097 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Q8WWN8 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11804589,11804589 cytoplasm 26 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota ARC HGNC:648 activity-regulated cytoskeleton-associated protein Q7LC44 Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. Kinetochore (GO:0000776) 11780067 cytoplasm 24 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota ARCN1 HGNC:649 archain 1 P48444 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytosol (GO:0005829) 1898986,8355790,15561729 cytoplasm 22 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota NA AREG HGNC:651 amphiregulin P15514 Membrane; Single-pass membrane protein. Plasma membrane (GO:0005886) 11038170 plasma membrane 9 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi AREGB HGNC:34509 amphiregulin B P15514 Membrane; Single-pass membrane protein. plasma membrane 9 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi AREL1 HGNC:20363 apoptosis resistant E3 ubiquitin protein ligase 1 O15033 Membrane; Single-pass membrane protein (Potential). Cytoplasm, cytosol. Integral to membrane (GO:0016021) nucleus 20 1 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota ARF1 HGNC:652 ADP-ribosylation factor 1 P84077 Golgi apparatus. Cytoplasm, perinuclear region. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endosome (GO:0005768); Golgi membrane (GO:0000139) 11278939,10858454,2105501,11726511,15793564,1680566,15781476,10828067,11278939,1680566,10858454,9417041 golgi apparatus 96 0 cytoplasm. endosome. golgi apparatus. golgi apparatus membrane multiple Eukaryota Eukaryota Cell.Organisms ARF3 HGNC:654 ADP-ribosylation factor 3 P61204 Golgi apparatus. Cytoplasm, perinuclear region. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10828067,8355790,8491770,2105501 golgi apparatus 100 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms ARF4 HGNC:655 ADP-ribosylation factor 4 P18085 Golgi apparatus. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10828067,8355790,8491770,2105501 golgi apparatus 100 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms ARF5 HGNC:658 ADP-ribosylation factor 5 P84085 Golgi apparatus. Cytoplasm, perinuclear region. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10828067,8355790,8491770,2105501 golgi apparatus 88 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms ARF6 HGNC:659 ADP-ribosylation factor 6 P62330 Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Cell membrane. Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. Cytosol (GO:0005829); Endosome (GO:0005768); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cell projection (GO:0042995) 12860984,8355790,16737952,11278939,16737952,9461590,16737952,8491770,2105501,16737952 golgi apparatus 96 0 cytoplasm. endosome. golgi apparatus multiple Opisthokonta Opisthokonta Cell.Organisms ARFGAP1 HGNC:15852 ADP-ribosylation factor GTPase activating protein 1 Q8N6T3 Cytoplasm (By similarity). Golgi apparatus (By similarity). Note=Associates with the Golgi complex (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 12181329,8533093,7969419,9733781,12379802,9405360 golgi apparatus 23 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota ARFGAP2 HGNC:13504 ADP-ribosylation factor GTPase activating protein 2 Q8N6H7 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum- Golgi intermediate compartment. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11278321,11278321 golgi apparatus 34 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ARFGAP3 HGNC:661 ADP-ribosylation factor GTPase activating protein 3 Q9NP61 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum- Golgi intermediate compartment. Cytoplasm (GO:0005737) 11172815,17081983 cytoplasm 32 0 cytoplasm cytoplasm NA NA Eukaryota ARFGEF1 HGNC:15772 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) Q9Y6D6 Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network (By similarity). Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment. Golgi apparatus (GO:0005794) 10393931 cytoplasm 26 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms ARFGEF2 HGNC:15853 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) Q9Y6D5 Cytoplasm. Membrane. Golgi apparatus. Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network (By similarity). Endosome (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite (By similarity). Cytoplasmic vesicle (By similarity). Cell junction, synapse (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Nucleus (GO:0005634); Microtubule (GO:0005874); Golgi vesicle (GO:0005798) 10716990,17081983,10716990,10716990,11777925,15198677,15198677,15198677,15198677,15198677 cytoplasm 22 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms ARFIP1 HGNC:21496 ADP-ribosylation factor interacting protein 1 P53367 Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 9038142,9038142 cytoplasm 6 0 cytoplasm. golgi apparatus multiple Euteleostomi Bilateria Eukaryota ARFIP2 HGNC:17160 ADP-ribosylation factor interacting protein 2 P53365 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11854752,11854752 nucleus 39 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa ARFRP1 HGNC:662 ADP-ribosylation factor related protein 1 Q13795 Golgi apparatus. Plasma membrane (GO:0005886) 8530503 golgi apparatus 100 0 golgi apparatus golgi apparatus Bilateria Eukaryota Cell.Organisms ARG1 HGNC:663 arginase 1 P05089 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576) 2913054,17113085,17113085,16188874 cytoplasm 100 0 cytoplasm. secreted multiple Eukaryota Cell.Organisms Cell.Organisms ARG2 HGNC:664 arginase 2 P78540 Mitochondrion. Mitochondrion (GO:0005739) 8898077,11370664,15598749 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ARGFX HGNC:30146 arginine-fifty homeobox A6NJG6 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Catarrhini Eutheria Opisthokonta ARGLU1 HGNC:25482 arginine and glutamate rich 1 Q9NWB6 Nucleus. Note=Recruited, in an estrogen- dependent manner, to ESR1 target gene promoters. Colocalizes with MED1. nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Euteleostomi ARHGAP1 HGNC:673 Rho GTPase activating protein 1 Q07960 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 1905930,14718574 cytoplasm 100 1 cytoplasm. secreted multiple Eukaryota Eukaryota Eukaryota ARHGAP10 HGNC:26099 Rho GTPase activating protein 10 A1A4S6 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane (By similarity). Note=Association to cell membrane is dependent on PH domain (By similarity). Cytoplasm (GO:0005737) 15471851 cytoplasm 36 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGAP11A HGNC:15783 Rho GTPase activating protein 11A Q6P4F7 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ARHGAP11B HGNC:15782 Rho GTPase activating protein 11B Q3KRB8 cytoplasm 16 2 cytoplasm cytoplasm Human Human Eukaryota ARHGAP12 HGNC:16348 Rho GTPase activating protein 12 Q8IWW6 Cytoplasm (GO:0005737) 17081983 cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ARHGAP15 HGNC:21030 Rho GTPase activating protein 15 Q53QZ3 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) 12650940 nucleus 18 0 cytoplasm cytoplasm Theria Bilateria Eukaryota ARHGAP17 HGNC:18239 Rho GTPase activating protein 17 Q68EM7 Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11431473,10967100,17081983,17081983 nucleus 12 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ARHGAP18 HGNC:21035 Rho GTPase activating protein 18 Q8N392 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ARHGAP19 HGNC:23724 Rho GTPase activating protein 19 Q14CB8 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ARHGAP20 HGNC:18357 Rho GTPase activating protein 20 Q9P2F6 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota ARHGAP21 HGNC:23725 Rho GTPase activating protein 21 Q5T5U3 Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. Golgi apparatus (GO:0005794) 17347647 cytoplasm 14 0 cytoplasm. golgi apparatus multiple Human Euteleostomi Cell.Organisms ARHGAP22 HGNC:30320 Rho GTPase activating protein 22 Q7Z5H3 Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota ARHGAP23 HGNC:29293 Rho GTPase activating protein 23 Q9P227 cytoplasm 17 0 cytoplasm cytoplasm NA NA NA ARHGAP24 HGNC:25361 Rho GTPase activating protein 24 Q8N264 Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions. cytoplasm 18 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota ARHGAP25 HGNC:28951 Rho GTPase activating protein 25 P42331 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota ARHGAP26 HGNC:17073 Rho GTPase activating protein 26 Q9UNA1 Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with actin stress fibers and cortical actin structures (By similarity). Cytoplasm (GO:0005737) 10908648 cytoplasm 26 2 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGAP27 HGNC:31813 Rho GTPase activating protein 27 Q6ZUM4 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Endosome (GO:0005768) 15147912 endoplasmic reticulum 20 0 endosome endosome NA NA Eukaryota ARHGAP28 HGNC:25509 Rho GTPase activating protein 28 Q9P2N2 cytoplasm 13 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota ARHGAP29 HGNC:30207 Rho GTPase activating protein 29 Q52LW3 Cytoplasm (GO:0005737) 17081983 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota ARHGAP30 HGNC:27414 Rho GTPase activating protein 30 Q7Z6I6 Cytoplasmic vesicle. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota ARHGAP31 HGNC:29216 Rho GTPase activating protein 31 Q2M1Z3 Cell projection, lamellipodium. Cell junction, focal adhesion (By similarity). cytoplasm 47 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota ARHGAP32 HGNC:17399 Rho GTPase activating protein 32 A7KAX9 Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine (By similarity). Cytoplasm, cell cortex. Endosome membrane (By similarity). Golgi apparatus membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Membrane. Note=Association to membrane via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment. Colocalizes with GAB2 at the cell membrane. cytoplasm 46 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota ARHGAP33 HGNC:23085 Rho GTPase activating protein 33 O14559 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12773384,12773384 cytoplasm 41 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota ARHGAP35 HGNC:4591 Rho GTPase activating protein 35 Q9NRY4 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) 8702520,17081983 cytoplasm 12 0 nucleus nucleus Bilateria Bilateria Eukaryota ARHGAP36 HGNC:26388 Rho GTPase activating protein 36 Q6ZRI8 cytoplasm 24 0 cytoplasm cytoplasm Eutheria Eutheria Eukaryota ARHGAP39 HGNC:29351 Rho GTPase activating protein 39 Q9C0H5 Nucleus (Potential). cytoplasm 18 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ARHGAP4 HGNC:674 Rho GTPase activating protein 4 P98171 Cytoplasm. Note=Just below the plasma membrane. Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737) 12414125,12115726,12414125,8570618,12115726 cytoplasm 100 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria NA ARHGAP40 HGNC:16226 Rho GTPase activating protein 40 Q5TG30 cytoplasm 18 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota ARHGAP42 HGNC:26545 Rho GTPase activating protein 42 A6NI28 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGAP44 HGNC:29096 Rho GTPase activating protein 44 Q17R89 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGAP5 HGNC:675 Rho GTPase activating protein 5 Q13017 Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8537347,8537347 nucleus 17 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGAP6 HGNC:676 Rho GTPase activating protein 6 O43182 Cytoplasm. Cytoplasm (GO:0005737) 10699171 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota ARHGAP8 HGNC:677 Rho GTPase activating protein 8 P85298 Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Cell projection (GO:0042995) 15944398/15064355,15064355,12944407 cytoplasm 47 0 cytoplasm cytoplasm NA NA Eukaryota ARHGAP9 HGNC:14130 Rho GTPase activating protein 9 Q9BRR9 cytoplasm 21 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota ARHGDIA HGNC:678 Rho GDP dissociation inhibitor (GDI) alpha P52565 Cytoplasm. Cytoplasm (GO:0005737) 9490022 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota ARHGDIB HGNC:679 Rho GDP dissociation inhibitor (GDI) beta P52566 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9490022,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Tetrapoda Euteleostomi Eukaryota ARHGDIG HGNC:680 Rho GDP dissociation inhibitor (GDI) gamma Q99819 Cytoplasm. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 8939998,11967128 cytoplasm 100 0 cytoplasm. golgi apparatus multiple NA NA Eukaryota ARHGEF1 HGNC:681 Rho guanine nucleotide exchange factor (GEF) 1 Q92888 Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12534370,12534370 cytoplasm 14 0 cytoplasm cytoplasm Eutheria Bilateria Eukaryota ARHGEF10 HGNC:14103 Rho guanine nucleotide exchange factor (GEF) 10 O15013 Cytoplasm (GO:0005737) 17081983 cytoplasm 35 2 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota ARHGEF10L HGNC:25540 Rho guanine nucleotide exchange factor (GEF) 10-like Q9HCE6 Cytoplasm. Cytoplasm (GO:0005737) 16112081 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota ARHGEF11 HGNC:14580 Rho guanine nucleotide exchange factor (GEF) 11 O15085 Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10900204,10900204 nucleus 24 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota ARHGEF12 HGNC:14193 Rho guanine nucleotide exchange factor (GEF) 12 Q9NZN5 Cytoplasm (Probable). Membrane (Probable). Note=Translocated to the membrane upon stimulation (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12220504,12220504 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota ARHGEF15 HGNC:15590 Rho guanine nucleotide exchange factor (GEF) 15 O94989 Cell projection, dendrite (By similarity). Note=Expressed exclusively in dendrites of the developing hippocampus (By similarity). cytoplasm 13 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota ARHGEF16 HGNC:15515 Rho guanine nucleotide exchange factor (GEF) 16 Q5VV41 Cytoplasm (Probable). cytoplasm 5 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota ARHGEF17 HGNC:21726 Rho guanine nucleotide exchange factor (GEF) 17 Q96PE2 cytoplasm 11 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGEF18 HGNC:17090 Rho/Rac guanine nucleotide exchange factor (GEF) 18 Q6ZSZ5 Cytoplasm. Note=Colocalizes with actin stress fibers. cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eukaryota ARHGEF19 HGNC:26604 Rho guanine nucleotide exchange factor (GEF) 19 Q8IW93 cytoplasm 7 0 cytoplasm cytoplasm Mammalia Deuterostomia Eukaryota ARHGEF2 HGNC:682 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Q92974 Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cell projection, ruffle membrane. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells. Cytoskeleton (GO:0005856); Microtubule (GO:0005874); Cytoplasm (GO:0005737) 11912491,9857026,15561729,17081983 cytoplasm 27 0 cytoplasm. golgi apparatus multiple Theria Euteleostomi Eukaryota ARHGEF25 HGNC:30275 Rho guanine nucleotide exchange factor (GEF) 25 Q86VW2 Cell membrane (By similarity). Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with actin regions. cytoplasm 55 0 cytoplasm cytoplasm NA NA Eukaryota ARHGEF26 HGNC:24490 Rho guanine nucleotide exchange factor (GEF) 26 Q96DR7 Cell projection, ruffle. cytoplasm 15 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota ARHGEF28 HGNC:30322 Rho guanine nucleotide exchange factor (GEF) 28 Q8N1W1 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the microtubule radial and cortical systems (By similarity). cytoplasm 33 0 cytoplasm cytoplasm NA NA Eukaryota ARHGEF3 HGNC:683 Rho guanine nucleotide exchange factor (GEF) 3 Q9NR81 Cytoplasm (By similarity). cytoplasm 94 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota ARHGEF33 HGNC:37252 Rho guanine nucleotide exchange factor (GEF) 33 A8MVX0 cytoplasm 11 0 cytoplasm cytoplasm Amniota Amniota Eukaryota ARHGEF35 HGNC:33846 Rho guanine nucleotide exchange factor (GEF) 35 A5YM69 cytoplasm 37 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Boreoeutheria ARHGEF37 HGNC:34430 Rho guanine nucleotide exchange factor (GEF) 37 A1IGU5 secreted 9 0 secreted secreted Euteleostomi Euteleostomi Eukaryota ARHGEF38 HGNC:25968 Rho guanine nucleotide exchange factor (GEF) 38 Q9NXL2 cytoplasm 19 0 cytoplasm cytoplasm NA NA Eukaryota ARHGEF39 HGNC:25909 Rho guanine nucleotide exchange factor (GEF) 39 Q8N4T4 Cell membrane. cytoplasm 9 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ARHGEF4 HGNC:684 Rho guanine nucleotide exchange factor (GEF) 4 Q9NR80 Isoform 3: Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Associated with membrane ruffles (Probable). Cytoplasm (GO:0005737) 10947987 cytoplasm 91 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ARHGEF40 HGNC:25516 Rho guanine nucleotide exchange factor (GEF) 40 Q8TER5 Cytoplasm. Note=Concentrated in the perinuclear region. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Deuterostomia Metazoa ARHGEF5 HGNC:13209 Rho guanine nucleotide exchange factor (GEF) 5 Q12774 plasma membrane 23 0 n/a n/a Tetrapoda Tetrapoda Eukaryota ARHGEF6 HGNC:685 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 Q15052 Cell projection, lamellipodium (By similarity). Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11017088/17081983,17081983 cytoplasm 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ARHGEF7 HGNC:15607 Rho guanine nucleotide exchange factor (GEF) 7 Q14155 Cell junction, focal adhesion (By similarity). Cell projection, ruffle (By similarity). Cytoplasm, cell cortex (By similarity). Cell projection, lamellipodium (By similarity). Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. Cytoplasm (GO:0005737); Synapse (GO:0045202); Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 9207241,15182672,15182672,15182672,17245428/17081983 cytoplasm 30 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARHGEF9 HGNC:14561 Cdc42 guanine nucleotide exchange factor (GEF) 9 O43307 Cytoplasm. Plasma membrane (GO:0005886) 10559246,10607391 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA ARID1A HGNC:11110 AT rich interactive domain 1A (SWI-like) O14497 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11159203,9434167,17081983,11159203,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota ARID1B HGNC:18040 AT rich interactive domain 1B (SWI1-like) Q8NFD5 Nucleus. Nucleus (GO:0005634) 11988099,17000644 nucleus 100 1 nucleus nucleus Deuterostomia Bilateria Eukaryota ARID2 HGNC:18037 AT rich interactive domain 2 (ARID, RFX-like) Q68CP9 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota ARID3A HGNC:3031 AT rich interactive domain 3A (BRIGHT-like) Q99856 Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. Nucleus (GO:0005634); Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737) 15203319,15017387,15017387,17081983 nucleus 61 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota ARID3B HGNC:14350 AT rich interactive domain 3B (BRIGHT-like) Q8IVW6 Nucleus. Nucleus (GO:0005634) 10446990 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ARID3C HGNC:21209 AT rich interactive domain 3C (BRIGHT-like) A6NKF2 Nucleus (By similarity). nucleus 59 0 nucleus nucleus Eutheria Eutheria Eukaryota ARID4A HGNC:9885 AT rich interactive domain 4A (RBP1-like) P29374 Nucleus. Nucleus (GO:0005634) 8455946 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ARID4B HGNC:15550 AT rich interactive domain 4B (RBP1-like) Q4LE39 Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells. Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 12724404/12724404,17081983,11790298,15247124,11481388,10369074,17081983 nucleus 35 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota ARID5A HGNC:17361 AT rich interactive domain 5A (MRF1-like) Q03989 Nucleus. Nucleus (GO:0005634) 8649988 nucleus 100 0 nucleus nucleus Theria Amniota Eukaryota ARID5B HGNC:17362 AT rich interactive domain 5B (MRF1-like) Q14865 Nucleus (By similarity). Nucleus (GO:0005634);Nucleus (GO:0005634) ,17000644/17081983 nucleus 85 0 nucleus nucleus Deuterostomia Bilateria Eukaryota ARIH1 HGNC:689 ariadne RBR E3 ubiquitin protein ligase 1 Q9Y4X5 Cytoplasm. Note=Mainly cytoplasmic. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11278816,11278816 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ARIH2 HGNC:690 ariadne RBR E3 ubiquitin protein ligase 2 O95376 Nucleus. Cytoplasm. Nucleus (GO:0005634) 10422847 cytoplasm 20 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ARIH2OS HGNC:34425 ariadne homolog 2 opposite strand Q8N7S6 Membrane; Single-pass membrane protein (Potential). mitochondrion 32 1 mitochondrion mitochondrion NA NA Eutheria ARL1 HGNC:692 ADP-ribosylation factor-like 1 P40616 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus (GO:0005794) 9624189 golgi apparatus 57 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Cell.Organisms ARL10 HGNC:22042 ADP-ribosylation factor-like 10 Q8N8L6 golgi apparatus 21 1 golgi apparatus golgi apparatus Chordata Chordata Eukaryota ARL11 HGNC:24046 ADP-ribosylation factor-like 11 Q969Q4 cytoplasm 33 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms ARL13A HGNC:31709 ADP-ribosylation factor-like 13A Q5H913 golgi apparatus 14 0 golgi apparatus golgi apparatus Euarchontoglires Euteleostomi Eukaryota ARL13B HGNC:25419 ADP-ribosylation factor-like 13B Q3SXY8 golgi apparatus 21 0 golgi apparatus golgi apparatus Chordata Eukaryota Eukaryota ARL14 HGNC:22974 ADP-ribosylation factor-like 14 Q8N4G2 Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms ARL14EP HGNC:26798 ADP-ribosylation factor-like 14 effector protein Q8N8R7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa ARL14EPL HGNC:44201 ADP-ribosylation factor-like 14 effector protein-like P0DKL9 cytoplasm 38 0 cytoplasm cytoplasm NA NA NA ARL15 HGNC:25945 ADP-ribosylation factor-like 15 Q9NXU5 golgi apparatus 18 0 golgi apparatus golgi apparatus Chordata Chordata Eukaryota ARL16 HGNC:27902 ADP-ribosylation factor-like 16 Q0P5N6 golgi apparatus 15 0 golgi apparatus golgi apparatus Chordata Chordata Eukaryota ARL17A HGNC:24096 ADP-ribosylation factor-like 17A Q8IVW1 Golgi apparatus (By similarity). golgi apparatus 67 0 golgi apparatus golgi apparatus Homininae Homininae Eukaryota ARL17B HGNC:32387 ADP-ribosylation factor-like 17B Q8IVW1 Golgi apparatus (By similarity). golgi apparatus 67 0 golgi apparatus golgi apparatus NA NA Eukaryota ARL2 HGNC:693 ADP-ribosylation factor-like 2 P36404 Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. Cytoplasm (GO:0005737) 8415637,12912990 cytoplasm 43 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms ARL2BP HGNC:17146 ADP-ribosylation factor-like 2 binding protein Q9Y2Y0 Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. nucleus 50 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota ARL3 HGNC:694 ADP-ribosylation factor-like 3 P36405 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12417528,12417528 cytoplasm 34 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms ARL4A HGNC:695 ADP-ribosylation factor-like 4A P40617 Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding. Nucleolus (GO:0005730); Nucleus (GO:0005634) 10980193,10980193,10462049 golgi apparatus 34 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms ARL4C HGNC:698 ADP-ribosylation factor-like 4C P56559 Cell projection, filopodium. Cell membrane. Cytoplasm. Nucleus (GO:0005634) 10462049 golgi apparatus 37 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms ARL4D HGNC:656 ADP-ribosylation factor-like 4D P49703 Nucleus, nucleolus (By similarity). Cell membrane. Nucleus. Cytoplasm. Nucleus (GO:0005634) 10462049 golgi apparatus 29 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms ARL5A HGNC:696 ADP-ribosylation factor-like 5A Q9Y689 Nucleus (GO:0005634); Nucleolus (GO:0005730) 12414990,12414990 golgi apparatus 38 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms ARL5B HGNC:23052 ADP-ribosylation factor-like 5B Q96KC2 golgi apparatus 40 0 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota ARL5C HGNC:31111 ADP-ribosylation factor-like 5C A6NH57 golgi apparatus 29 0 golgi apparatus golgi apparatus Eutheria Euteleostomi Eukaryota ARL6 HGNC:13210 ADP-ribosylation factor-like 6 Q9H0F7 Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Membrane fraction (GO:0005624) 10462049,10508919,10508919 cytoplasm 30 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms ARL6IP1 HGNC:697 ADP-ribosylation factor-like 6 interacting protein 1 Q15041 Endomembrane system; Multi-pass membrane protein. Note=Predominantly localized to intracytoplasmic membranes. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10995579,10995579 endoplasmic reticulum membrane 43 4 cytoplasm. endomembrane system. plasma membrane multiple Euteleostomi Bilateria Bilateria ARL6IP4 HGNC:18076 ADP-ribosylation-like factor 6 interacting protein 4 Q66PJ3 Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Nucleolus (GO:0005730) 17081983,17081983/10708573,15635413 nucleus 14 0 cytoplasm. nucleus multiple Eutheria Bilateria Eukaryota ARL6IP5 HGNC:16937 ADP-ribosylation-like factor 6 interacting protein 5 O75915 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11242046,11242046 endoplasmic reticulum membrane 52 4 cytoplasm. plasma membrane multiple Bilateria Bilateria Eumetazoa ARL6IP6 HGNC:24048 ADP-ribosylation-like factor 6 interacting protein 6 Q8N6S5 Membrane; Multi-pass membrane protein (Potential). plasma membrane 66 3 plasma membrane plasma membrane Theria Euteleostomi Craniata ARL8A HGNC:25192 ADP-ribosylation factor-like 8A Q96BM9 Late endosome membrane. Lysosome membrane. golgi apparatus 17 0 golgi apparatus golgi apparatus Bilateria Eukaryota Cell.Organisms ARL8B HGNC:25564 ADP-ribosylation factor-like 8B Q9NVJ2 Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=According to PubMed:15331635, it localizes with microtubules at the spindle mid-zone during mitosis. Cytoskeleton (GO:0005856) 15331635 golgi apparatus 20 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms ARL9 HGNC:23592 ADP-ribosylation factor-like 9 Q6T311 golgi apparatus 21 0 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Cell.Organisms ARMC1 HGNC:17684 armadillo repeat containing 1 Q9NVT9 cytoplasm 33 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ARMC10 HGNC:21706 armadillo repeat containing 10 Q8N2F6 Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12839973 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Euteleostomi Eumetazoa ARMC12 HGNC:21099 armadillo repeat containing 12 Q5T9G4 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 endoplasmic reticulum membrane 5 1 cytoplasm. nucleus multiple Mammalia Mammalia Chordata ARMC2 HGNC:23045 armadillo repeat containing 2 Q8NEN0 nucleus 37 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ARMC3 HGNC:30964 armadillo repeat containing 3 Q5W041 secreted 6 0 secreted secreted Deuterostomia Deuterostomia Eukaryota ARMC4 HGNC:25583 armadillo repeat containing 4 Q5T2S8 nucleus 10 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms ARMC5 HGNC:25781 armadillo repeat containing 5 Q96C12 nucleus 11 0 nucleus nucleus Mammalia Euteleostomi Eukaryota ARMC6 HGNC:25049 armadillo repeat containing 6 Q6NXE6 nucleus 12 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ARMC7 HGNC:26168 armadillo repeat containing 7 Q9H6L4 nucleus 14 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ARMC8 HGNC:24999 armadillo repeat containing 8 Q8IUR7 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ARMC9 HGNC:20730 armadillo repeat containing 9 Q7Z3E5 nucleus 73 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ARMCX1 HGNC:18073 armadillo repeat containing, X-linked 1 Q9P291 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11162520 endoplasmic reticulum membrane 38 1 plasma membrane plasma membrane Eutheria Eutheria NA ARMCX2 HGNC:16869 armadillo repeat containing, X-linked 2 Q7L311 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11162520 endoplasmic reticulum membrane 32 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eutheria NA ARMCX3 HGNC:24065 armadillo repeat containing, X-linked 3 Q9UH62 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11162520,17081983 endoplasmic reticulum membrane 38 1 cytoplasm. plasma membrane multiple Eutheria Eutheria NA ARMCX4 HGNC:28615 armadillo repeat containing, X-linked 4 Q5H9R4 Membrane; Single-pass membrane protein (Potential). cytoplasm 12 1 cytoplasm cytoplasm Eutheria Eutheria NA ARMCX5 HGNC:25772 armadillo repeat containing, X-linked 5 Q6P1M9 Nucleus (GO:0005634) endoplasmic reticulum membrane 17 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eutheria Euteleostomi ARMCX6 HGNC:26094 armadillo repeat containing, X-linked 6 Q7L4S7 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) ,17081983 endoplasmic reticulum membrane 21 1 plasma membrane plasma membrane Eutheria Eutheria NA ARMS2 HGNC:32685 age-related maculopathy susceptibility 2 P0C7Q2 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm NA NA Primates ARNT HGNC:700 aryl hydrocarbon receptor nuclear translocator P27540 Nucleus. Nucleus (GO:0005634) 1317062 nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ARNT2 HGNC:16876 aryl-hydrocarbon receptor nuclear translocator 2 Q9HBZ2 Nucleus (Potential). Nucleus (GO:0005634) 12239177 nucleus 58 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ARNTL HGNC:701 aryl hydrocarbon receptor nuclear translocator-like O00327 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,12897057,18644859,,12897057 nucleus 98 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms ARNTL2 HGNC:18984 aryl hydrocarbon receptor nuclear translocator-like 2 Q8WYA1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10964693,10964693 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms ARPC1A HGNC:703 actin related protein 2/3 complex, subunit 1A, 41kDa Q92747 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9359840,15635413 cytoplasm 62 0 cytoplasm. nucleus multiple NA NA Cell.Organisms ARPC1B HGNC:704 actin related protein 2/3 complex, subunit 1B, 41kDa O15143 Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 9230079,15635413,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms ARPC2 HGNC:705 actin related protein 2/3 complex, subunit 2, 34kDa O15144 Cytoplasm, cytoskeleton. Cell projection. Actin cytoskeleton (GO:0015629);Actin cytoskeleton (GO:0015629); Nucleolus (GO:0005730) 9359840/9230079,15635413 cytoplasm 38 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota ARPC3 HGNC:706 actin related protein 2/3 complex, subunit 3, 21kDa O15145 Cytoplasm, cytoskeleton. Cell projection. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9230079,9359840,11790298,15635413 cytoplasm 42 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ARPC4 HGNC:707 actin related protein 2/3 complex, subunit 4, 20kDa P59998 Cytoplasm, cytoskeleton. Cell projection. Cytoskeleton (GO:0005856); Nucleolus (GO:0005730) 9230079,15635413 cytoplasm 61 0 cytoplasm. nucleus multiple NA NA Eukaryota ARPC5 HGNC:708 actin related protein 2/3 complex, subunit 5, 16kDa O15511 Cytoplasm, cytoskeleton. Cell projection. Cytoskeleton (GO:0005856) 9230079 cytoplasm 14 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota ARPC5L HGNC:23366 actin related protein 2/3 complex, subunit 5-like Q9BPX5 Cytoplasm, cytoskeleton (By similarity). cytoplasm 12 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota ARPP19 HGNC:16967 cAMP-regulated phosphoprotein, 19kDa P56211 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 2160982 cytoplasm 99 0 cytoplasm cytoplasm Chordata Opisthokonta Opisthokonta ARPP21 HGNC:16968 cAMP-regulated phosphoprotein, 21kDa Q9UBL0 Cytoplasm (By similarity). cytoplasm 84 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota ARR3 HGNC:710 arrestin 3, retinal (X-arrestin) P36575 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11063754,12853434 cytoplasm 44 0 cytoplasm cytoplasm Theria Tetrapoda Holozoa ARRB1 HGNC:711 arrestin, beta 1 P49407 Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit (Probable). Cell projection, pseudopodium (By similarity). Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). Cytoplasm (GO:0005737); Endosome (GO:0005768); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12538596,10347182,9924018,10770944,12399592,12538596 nucleus 37 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Holozoa ARRB2 HGNC:712 arrestin, beta 2 P32121 Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit (By similarity). Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12538596,12538596,9346876 cytoplasm 54 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa ARRDC1 HGNC:28633 arrestin domain containing 1 Q8N5I2 cytoplasm 12 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta ARRDC2 HGNC:25225 arrestin domain containing 2 Q8TBH0 cytoplasm 43 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Eukaryota ARRDC3 HGNC:29263 arrestin domain containing 3 Q96B67 Cytoplasm. Note=Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ARRDC4 HGNC:28087 arrestin domain containing 4 Q8NCT1 cytoplasm 42 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota ARRDC5 HGNC:31407 arrestin domain containing 5 A6NEK1 cytoplasm 10 0 cytoplasm cytoplasm Eutheria Eutheria Opisthokonta ARSA HGNC:713 arylsulfatase A P15289 Lysosome. Extracellular (GO:0005576); Lysosome (GO:0005764) 10359658,10359658 secreted 26 0 lysosome. secreted multiple Euteleostomi Cell.Organisms Cell.Organisms ARSB HGNC:714 arylsulfatase B P15848 Lysosome. Lysosome (GO:0005764) 2303452 golgi apparatus 17 0 lysosome lysosome Bilateria Cell.Organisms Cell.Organisms ARSD HGNC:717 arylsulfatase D P51689 Lysosome (Potential). Endoplasmic reticulum (GO:0005783) 11177574 golgi apparatus 54 2 endoplasmic reticulum endoplasmic reticulum Euteleostomi Cell.Organisms Cell.Organisms ARSE HGNC:719 arylsulfatase E (chondrodysplasia punctata 1) P51690 Golgi apparatus, Golgi stack. Golgi apparatus (GO:0005794) 9497243 golgi apparatus 100 2 golgi apparatus golgi apparatus Euteleostomi Cell.Organisms Cell.Organisms ARSF HGNC:721 arylsulfatase F P54793 Secreted (Potential). Endoplasmic reticulum (GO:0005783) 9229115 golgi apparatus 48 2 endoplasmic reticulum endoplasmic reticulum Euteleostomi Cell.Organisms Cell.Organisms ARSG HGNC:24102 arylsulfatase G Q96EG1 Lysosome. Note=Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins. Endoplasmic reticulum (GO:0005783) 12461688 secreted 23 0 endoplasmic reticulum. lysosome multiple Chordata Chordata NA ARSH HGNC:32488 arylsulfatase family, member H Q5FYA8 Membrane; Multi-pass membrane protein (Potential). golgi apparatus 51 2 golgi apparatus golgi apparatus Euteleostomi Cell.Organisms Cell.Organisms ARSI HGNC:32521 arylsulfatase family, member I Q5FYB1 Secreted. Endoplasmic reticulum. Note=Localized in the intracellular granular structures. golgi apparatus 27 0 endoplasmic reticulum. secreted multiple Bilateria Cell.Organisms Cell.Organisms ARSJ HGNC:26286 arylsulfatase family, member J Q5FYB0 Secreted (Potential). secreted 11 1 secreted secreted Bilateria Cell.Organisms Cell.Organisms ARSK HGNC:25239 arylsulfatase family, member K Q6UWY0 Secreted (Potential). golgi apparatus 17 0 golgi apparatus golgi apparatus Euteleostomi Cell.Organisms Cell.Organisms ART1 HGNC:723 ADP-ribosyltransferase 1 P52961 Sarcoplasmic reticulum membrane; Lipid- anchor, GPI-anchor. Plasma membrane (GO:0005886) 7947688,10092875 secreted 33 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa ART3 HGNC:725 ADP-ribosyltransferase 3 Q13508 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 9119374,10460751 secreted 21 1 plasma membrane plasma membrane Theria Theria Euteleostomi ART4 HGNC:726 ADP-ribosyltransferase 4 (Dombrock blood group) Q93070 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 9119374 secreted 26 1 plasma membrane plasma membrane Eutheria Amniota Eumetazoa ART5 HGNC:24049 ADP-ribosyltransferase 5 Q96L15 Secreted (Potential). Extracellular (GO:0005576) 12070318,11587854,10448534 secreted 28 1 secreted secreted Mammalia Tetrapoda Eumetazoa ARTN HGNC:727 artemin Q5T4W7 Secreted (By similarity). Extracellular (GO:0005576) 9883723 secreted 35 1 secreted secreted Euarchontoglires Euteleostomi Craniata ARV1 HGNC:29561 ARV1 homolog (S. cerevisiae) Q9H2C2 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12145310,12145310 secreted 59 5 endoplasmic reticulum. golgi apparatus multiple Bilateria Eukaryota Eukaryota ARVCF HGNC:728 armadillo repeat gene deleted in velocardiofacial syndrome O00192 Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11058098,11058098,10725230 secreted 23 0 nucleus nucleus Chordata Chordata Eukaryota ARX HGNC:18060 aristaless related homeobox Q96QS3 Nucleus (By similarity). Nucleus (GO:0005634) 11971879 nucleus 33 0 nucleus nucleus Euteleostomi Bilateria Eukaryota AS3MT HGNC:17452 arsenic (+3 oxidation state) methyltransferase Q9HBK9 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11790780 cytoplasm 72 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms ASAH1 HGNC:735 N-acylsphingosine amidohydrolase (acid ceramidase) 1 Q13510 Lysosome. Lysosome (GO:0005764) 11451951 secreted 64 0 lysosome lysosome Deuterostomia Eukaryota Eukaryota ASAH2 HGNC:18860 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 Q9NR71 Cell membrane; Single-pass type II membrane protein. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 15845354,15845354,15845354,10781606 plasma membrane 100 0 endoplasmic reticulum. golgi apparatus. mitochondrion. plasma membrane multiple Deuterostomia Cell.Organisms Cell.Organisms ASAH2B HGNC:23456 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B P0C7U1 plasma membrane 93 0 n/a n/a Homininae Homininae Cell.Organisms ASAP1 HGNC:2720 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Q9ULH1 Cytoplasm (By similarity). Membrane (By similarity). Note=Predominantly cytoplasmic (By similarity). Partially membrane-associated (By similarity). Cytoplasm (GO:0005737); Cell projection (GO:0042995) 9819391,17255943 cytoplasm 36 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ASAP2 HGNC:2721 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 O43150 Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794);Cytoplasm (GO:0005737) 10749932,10749932,10022920,10022920/17081983 cytoplasm 36 0 cytoplasm. golgi apparatus multiple Deuterostomia Eukaryota Cell.Organisms ASAP3 HGNC:14987 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Q8TDY4 Cytoplasm. Cell projection (GO:0042995); Endosome (GO:0005768); Cytosol (GO:0005829) 16737952,16737952,16737952 cytoplasm 100 0 cytoplasm. endosome multiple Deuterostomia Eukaryota Cell.Organisms ASB1 HGNC:16011 ankyrin repeat and SOCS box containing 1 Q9Y576 Cytoplasm (GO:0005737) 11509662 mitochondrion 15 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms ASB10 HGNC:17185 ankyrin repeat and SOCS box containing 10 Q8WXI3 nucleus 20 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms ASB11 HGNC:17186 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase Q8WXH4 mitochondrion 44 0 mitochondrion mitochondrion Amniota Amniota Cell.Organisms ASB12 HGNC:19763 ankyrin repeat and SOCS box containing 12 Q8WXK4 nucleus 15 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms ASB13 HGNC:19765 ankyrin repeat and SOCS box containing 13 Q8WXK3 mitochondrion 28 0 mitochondrion mitochondrion Deuterostomia Eukaryota Cell.Organisms ASB14 HGNC:19766 ankyrin repeat and SOCS box containing 14 A6NK59 nucleus 17 0 nucleus nucleus NA NA Cell.Organisms ASB15 HGNC:19767 ankyrin repeat and SOCS box containing 15 Q8WXK1 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms ASB16 HGNC:19768 ankyrin repeat and SOCS box containing 16 Q96NS5 nucleus 20 0 nucleus nucleus Theria Euteleostomi Cell.Organisms ASB17 HGNC:19769 ankyrin repeat and SOCS box containing 17 Q8WXJ9 mitochondrion 24 0 mitochondrion mitochondrion Mammalia Mammalia Bilateria ASB18 HGNC:19770 ankyrin repeat and SOCS box containing 18 Q6ZVZ8 cytoplasm 18 0 cytoplasm cytoplasm Human Euteleostomi Cell.Organisms ASB2 HGNC:16012 ankyrin repeat and SOCS box containing 2 Q96Q27 Cytoplasm (GO:0005737) 11509662 nucleus membrane 21 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms ASB3 HGNC:16013 ankyrin repeat and SOCS box containing 3 Q9Y575 nucleus 20 0 nucleus nucleus Euteleostomi Deuterostomia NA ASB4 HGNC:16009 ankyrin repeat and SOCS box containing 4 Q9Y574 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms ASB5 HGNC:17180 ankyrin repeat and SOCS box containing 5 Q8WWX0 Integral to membrane (GO:0016021) mitochondrion 41 0 mitochondrion mitochondrion Euteleostomi Deuterostomia Cell.Organisms ASB6 HGNC:17181 ankyrin repeat and SOCS box containing 6 Q9NWX5 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 88 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms ASB7 HGNC:17182 ankyrin repeat and SOCS box containing 7 Q9H672 nucleus 19 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms ASB8 HGNC:17183 ankyrin repeat and SOCS box containing 8 Q9H765 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12559969,12559969 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms ASB9 HGNC:17184 ankyrin repeat and SOCS box containing 9 Q96DX5 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Euteleostomi Cell.Organisms ASCC1 HGNC:24268 activating signal cointegrator 1 complex subunit 1 Q8N9N2 Cytoplasm. Nucleus (GO:0005634) 12077347 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ASCC2 HGNC:24103 activating signal cointegrator 1 complex subunit 2 Q9H1I8 Nucleus (GO:0005634) 12077347 nucleus 93 0 nucleus nucleus Theria Eukaryota Eukaryota ASCC3 HGNC:18697 activating signal cointegrator 1 complex subunit 3 Q8N3C0 Nucleus. Cytoplasm. Nucleus (GO:0005634) 12077347,17000644 cytoplasm 36 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ASCL1 HGNC:738 achaete-scute family bHLH transcription factor 1 P50553 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11171979,11309412 nucleus 51 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa ASCL2 HGNC:739 achaete-scute family bHLH transcription factor 2 Q99929 Nucleus. Nucleus (GO:0005634) 11440538 nucleus 100 0 nucleus nucleus Eutheria Eutheria Eumetazoa ASCL3 HGNC:740 achaete-scute family bHLH transcription factor 3 Q9NQ33 Nucleus. Nucleus (GO:0005634) 11784080 nucleus 100 0 nucleus nucleus Amniota Bilateria Metazoa ASCL4 HGNC:24311 achaete-scute family bHLH transcription factor 4 Q6XD76 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 55 0 nucleus nucleus Amniota Amniota Eumetazoa ASCL5 HGNC:33169 achaete-scute family bHLH transcription factor 5 Q7RTU5 Nucleus (By similarity). nucleus 45 0 nucleus nucleus NA NA NA ASF1A HGNC:20995 anti-silencing function 1A histone chaperone Q9Y294 Nucleus. Nucleus (GO:0005634) 12842904 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ASF1B HGNC:20996 anti-silencing function 1B histone chaperone Q9NVP2 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12842904,12842904 nucleus 100 0 cytoplasm. nucleus multiple Human Human Eukaryota ASGR1 HGNC:742 asialoglycoprotein receptor 1 P07306 Isoform H1a: Membrane; Single-pass type II membrane protein. Isoform H1b: Secreted. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 3234178,2982798 secreted 20 1 endoplasmic reticulum. plasma membrane. secreted multiple Eutheria Tetrapoda Cell.Organisms ASGR2 HGNC:743 asialoglycoprotein receptor 2 P07307 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 3234178,8397210,1597447,7843709 secreted 25 1 endoplasmic reticulum. golgi apparatus. plasma membrane. secreted multiple Theria Theria Cell.Organisms ASH1L HGNC:19088 ash1 (absent, small, or homeotic)-like (Drosophila) Q9NR48 Nucleus. Cell junction, tight junction. Chromosome (Probable). Note=The relevance of tight junction localization is however unclear. Nucleus (GO:0005634); Plasma membrane (GO:0005886) 10860993,10860993 nucleus 36 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ASH2L HGNC:744 ash2 (absent, small, or homeotic)-like (Drosophila) Q9UBL3 Nucleus (Probable). Nucleus (GO:0005634) ,10393421,15199122,16253997, nucleus 23 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ASIC1 HGNC:100 acid-sensing (proton-gated) ion channel 1 P78348 Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9037075,11988176 plasma membrane 60 2 plasma membrane. secreted multiple Bilateria Bilateria Metazoa ASIC2 HGNC:99 acid-sensing (proton-gated) ion channel 2 Q16515 Cell membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes (By similarity). Plasma membrane (GO:0005886) 9037075,11739374,8626462 plasma membrane 99 2 plasma membrane plasma membrane Bilateria Bilateria Metazoa ASIC3 HGNC:101 acid-sensing (proton-gated) ion channel 3 Q9UHC3 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). Plasma membrane (GO:0005886) 11842212,15317815 plasma membrane 40 2 plasma membrane plasma membrane Bilateria Bilateria Metazoa ASIC4 HGNC:21263 acid-sensing (proton-gated) ion channel family member 4 Q96FT7 Membrane; Multi-pass membrane protein (By similarity). plasma membrane 41 2 plasma membrane plasma membrane Theria Bilateria Metazoa ASIC5 HGNC:17537 acid-sensing (proton-gated) ion channel family member 5 Q9NY37 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 2 plasma membrane plasma membrane NA NA Metazoa ASIP HGNC:745 agouti signaling protein P42127 Secreted. secreted 100 0 secreted secreted Theria Euteleostomi Eutheria ASL HGNC:746 argininosuccinate lyase P04424 cytoplasm 65 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms ASMT HGNC:750 acetylserotonin O-methyltransferase P46597 Cytoplasm (GO:0005737) 1878930 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms ASMTL HGNC:751 acetylserotonin O-methyltransferase-like O95671 Cytoplasm (GO:0005737) 17081983 cytoplasm 17 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ASNA1 HGNC:752 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) O43681 Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 9736449,9736449,9736449 mitochondrion 43 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ASNS HGNC:753 asparagine synthetase (glutamine-hydrolyzing) P08243 Cytoplasm (GO:0005737); Cytosol (GO:0005829) 8093451,15561729 cytoplasm 12 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ASNSD1 HGNC:24910 asparagine synthetase domain containing 1 Q9NWL6 cytoplasm 24 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ASPA HGNC:756 aspartoacylase P45381 Cytoplasm. Nucleus (By similarity). Mitochondrion (GO:0005739) 10837925 cytoplasm 32 0 cytoplasm. mitochondrion multiple Euteleostomi Euteleostomi Cell.Organisms ASPDH HGNC:33856 aspartate dehydrogenase domain containing A6ND91 mitochondrion 33 0 mitochondrion mitochondrion Eutheria Cell.Organisms Cell.Organisms ASPG HGNC:20123 asparaginase Q86U10 plasma membrane 18 0 n/a n/a Cell.Organisms Cell.Organisms Cell.Organisms ASPH HGNC:757 aspartate beta-hydroxylase Q12797 Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 11007777 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Cell.Organisms Cell.Organisms ASPHD1 HGNC:27380 aspartate beta-hydroxylase domain containing 1 Q5U4P2 Membrane; Single-pass type II membrane protein (Potential). endoplasmic reticulum membrane 26 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Cell.Organisms ASPHD2 HGNC:30437 aspartate beta-hydroxylase domain containing 2 Q6ICH7 Membrane; Single-pass type II membrane protein (Potential). endoplasmic reticulum membrane 17 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Eukaryota Cell.Organisms ASPM HGNC:19048 asp (abnormal spindle) homolog, microcephaly associated (Drosophila) Q8IZT6 Cytoplasm (By similarity). Cytoplasm, cytoskeleton, spindle. Nucleus (By similarity). Note=The nuclear- cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis. Nucleus (GO:0005634); Microtubule (GO:0005874) 12355089,17081983,15561729 nucleus 12 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota ASPN HGNC:14872 asporin Q9BXN1 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11152692 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms ASPRV1 HGNC:26321 aspartic peptidase, retroviral-like 1 Q53RT3 Membrane; Single-pass membrane protein (Potential). cytoplasm 20 1 cytoplasm cytoplasm NA NA Olfactores ASPSCR1 HGNC:13825 alveolar soft part sarcoma chromosome region, candidate 1 Q9BZE9 Endomembrane system; Peripheral membrane protein (By similarity). Cytoplasm. Nucleus. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14562105,14562105,14562105 cytoplasm 18 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota ASRGL1 HGNC:16448 asparaginase like 1 Q7L266 Cytoplasm. Note=Midpiece of sperm tail. Mitochondrion (GO:0005739) 11984834 cytoplasm 100 0 cytoplasm. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms ASS1 HGNC:758 argininosuccinate synthase 1 P00966 Cytosol (GO:0005829); Nucleus (GO:0005634); Microsome (GO:0005792) 1312326,1312326,1312326 cytoplasm 43 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ASTE1 HGNC:25021 asteroid homolog 1 (Drosophila) Q2TB18 nucleus 55 0 nucleus nucleus Deuterostomia Opisthokonta Opisthokonta ASTL HGNC:31704 astacin-like metallo-endopeptidase (M12 family) Q6HA08 Cytoplasm (By similarity). Cell membrane (By similarity). Cytoplasmic granule (By similarity). Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Secretory granules. Localizes to the peripheral cortical granules of ovulated eggs. Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles shortly after birth. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS). Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS) (By similarity). secreted 25 0 secreted secreted Bilateria Bilateria Cell.Organisms ASTN1 HGNC:773 astrotactin 1 O14525 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 3276720 secreted 30 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa ASTN2 HGNC:17021 astrotactin 2 O75129 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 28 2 n/a n/a Euteleostomi Euteleostomi Holozoa ASUN HGNC:20174 asunder spermatogenesis regulator Q9NVM9 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ASXL1 HGNC:18318 additional sex combs like 1 (Drosophila) Q8IXJ9 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 69 0 nucleus nucleus Theria Amniota Metazoa ASXL2 HGNC:23805 additional sex combs like 2 (Drosophila) Q76L83 Nucleus (Probable). nucleus 28 0 nucleus nucleus Tetrapoda Tetrapoda Metazoa ASXL3 HGNC:29357 additional sex combs like 3 (Drosophila) Q9C0F0 Nucleus (Probable). nucleus 40 1 nucleus nucleus Tetrapoda Bilateria Eumetazoa ASZ1 HGNC:1350 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Q8WWH4 Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15364959,12040005 cytoplasm 82 1 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms ATAD1 HGNC:25903 ATPase family, AAA domain containing 1 Q8NBU5 Peroxisome (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15598749,17081983 mitochondrion membrane 33 1 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms ATAD2 HGNC:30123 ATPase family, AAA domain containing 2 Q6PL18 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms ATAD2B HGNC:29230 ATPase family, AAA domain containing 2B Q9ULI0 nucleus 46 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms ATAD3A HGNC:25567 ATPase family, AAA domain containing 3A Q9NVI7 Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N- terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids. nucleus 30 0 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Cell.Organisms ATAD3B HGNC:24007 ATPase family, AAA domain containing 3B Q5T9A4 Mitochondrion inner membrane; Peripheral membrane protein. Note=Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A. Mitochondrion (GO:0005739) 15598749 cytoplasm 19 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms ATAD3C HGNC:32151 ATPase family, AAA domain containing 3C Q5T2N8 mitochondrion membrane 17 0 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Cell.Organisms ATAD5 HGNC:25752 ATPase family, AAA domain containing 5 Q96QE3 Nucleus (Potential). nucleus 16 0 nucleus nucleus Chordata Chordata Cell.Organisms ATAT1 HGNC:21186 alpha tubulin acetyltransferase 1 Q5SQI0 nucleus 45 0 nucleus nucleus Bilateria Eukaryota NA ATCAY HGNC:779 ataxia, cerebellar, Cayman type Q86WG3 Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Cytoplasm. Mitochondrion envelope. Note=Localizes presynaptically into neuron projections. cytoplasm 54 3 cytoplasm. mitochondrion multiple Chordata Chordata Eukaryota ATE1 HGNC:782 arginyltransferase 1 O95260 Isoform ATE1-1: Nucleus (By similarity). Cytoplasm (By similarity). Isoform ATE1-2: Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9858543,9858543 cytoplasm 29 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms ATF1 HGNC:783 activating transcription factor 1 P18846 Nucleus. Nucleus (GO:0005634) 11014230 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Opisthokonta ATF2 HGNC:784 activating transcription factor 2 P15336 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9488727,16511568,19059367,16511568,17081983 nucleus 36 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota ATF3 HGNC:785 activating transcription factor 3 P18847 Nucleus. Nucleus (GO:0005634) 8622660 nucleus 100 0 nucleus nucleus Chordata Bilateria Eumetazoa ATF4 HGNC:786 activating transcription factor 4 P18848 Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9190894,11087824,11087824 nucleus 18 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata ATF5 HGNC:790 activating transcription factor 5 Q9Y2D1 Cytoplasm. Nucleus. Nucleus (GO:0005634) 1371974,15358120 secreted 27 0 cytoplasm. nucleus multiple Catarrhini Euteleostomi Holozoa ATF6 HGNC:791 activating transcription factor 6 P18850 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 12076252,12782636,12076252,9271374,12782636,12782636 nucleus 39 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. nucleus multiple Euteleostomi Bilateria Eukaryota ATF6B HGNC:2349 activating transcription factor 6 beta Q99941 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 8870652,11256944,8870652,11256944,12782636 nucleus 35 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. nucleus multiple Euteleostomi Eukaryota NA ATF7 HGNC:792 activating transcription factor 7 P17544 Nucleus. Nucleus, nucleoplasm. Isoform 5: Cytoplasm. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10698518,8939888/17081983,17081983 nucleus 38 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eukaryota ATF7IP HGNC:20092 activating transcription factor 7 interacting protein Q6VMQ6 Nucleus. Nucleus (GO:0005634) 10777215 nucleus 100 0 nucleus nucleus Amniota Amniota Eumetazoa ATF7IP2 HGNC:20397 activating transcription factor 7 interacting protein 2 Q5U623 Nucleus. nucleus 100 0 nucleus nucleus Mammalia Mammalia Eumetazoa ATG10 HGNC:20315 autophagy related 10 Q9H0Y0 Cytoplasm (Probable). cytoplasm 14 1 cytoplasm cytoplasm Amniota Eukaryota Eukaryota ATG101 HGNC:25679 autophagy related 101 Q9BSB4 Cytoplasm. Preautophagosomal structure. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. nucleus 21 0 cytoplasm. preautophagosomal structure multiple Eutheria Eukaryota Eukaryota ATG12 HGNC:588 autophagy related 12 O94817 Cytoplasm (By similarity). Preautophagosomal structure membrane; Peripheral membrane protein. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. Cytoplasm (GO:0005737) cytoplasm 17 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota ATG13 HGNC:29091 autophagy related 13 O75143 Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation (By similarity). nucleus 68 0 nucleus nucleus Euteleostomi Deuterostomia Metazoa ATG14 HGNC:19962 autophagy related 14 Q6ZNE5 Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Nucleus (GO:0005634) 17081983 nucleus 80 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Metazoa ATG16L1 HGNC:21498 autophagy related 16-like 1 (S. cerevisiae) Q676U5 Cytoplasm (By similarity). Preautophagosomal structure membrane; Peripheral membrane protein (By similarity). Note=Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity). Cytosol (GO:0005829); Integral to membrane (GO:0016021) 12665549,12665549 nucleus 11 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ATG16L2 HGNC:25464 autophagy related 16-like 2 (S. cerevisiae) Q8NAA4 Cytoplasm (By similarity). nucleus 13 0 nucleus nucleus Mammalia Tetrapoda Cell.Organisms ATG2A HGNC:29028 autophagy related 2A Q2TAZ0 Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. nucleus 34 0 lipid droplet lipid droplet Bilateria Eukaryota Eukaryota ATG2B HGNC:20187 autophagy related 2B Q96BY7 Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. nucleus 36 0 lipid droplet lipid droplet Bilateria Eukaryota Eukaryota ATG3 HGNC:20962 autophagy related 3 Q9NT62 Cytoplasm. Cytoplasm (GO:0005737) 11825910 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATG4A HGNC:16489 autophagy related 4A, cysteine peptidase Q8WYN0 Cytoplasm (Probable). Cytoplasm (GO:0005737) 12446702 cytoplasm 23 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ATG4B HGNC:20790 autophagy related 4B, cysteine peptidase Q9Y4P1 Cytoplasm (Probable). Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15187094/17081983,17081983 cytoplasm 24 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ATG4C HGNC:16040 autophagy related 4C, cysteine peptidase Q96DT6 Cytoplasm (Probable). cytoplasm 26 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATG4D HGNC:20789 autophagy related 4D, cysteine peptidase Q86TL0 Cytoplasm (Probable). Cytoplasm (GO:0005737) 12446702 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATG5 HGNC:589 autophagy related 5 Q9H1Y0 Cytoplasm. Note=Colocalizes with nonmuscle actin. Cytoskeleton (GO:0005856) 7796880 nucleus 13 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATG7 HGNC:16935 autophagy related 7 O95352 Cytoplasm (Probable). Cytoplasm (GO:0005737) 10233149 nucleus 17 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ATG9A HGNC:22408 autophagy related 9A Q7Z3C6 Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1, ATG13, as well as SH3GLB1. Cytosol (GO:0005829); Perinuclear region (GO:0048471);Nucleus (GO:0005634) 15755735,15755735/17081983 endoplasmic reticulum membrane 29 9 cytoplasm. endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. nucleus multiple Opisthokonta Eukaryota Eukaryota ATG9B HGNC:21899 autophagy related 9B Q674R7 Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1 and ATG13. Perinuclear region (GO:0048471); Cytoplasm (GO:0005737) 15755735,15755735 plasma membrane 80 8 cytoplasm cytoplasm Catarrhini Mammalia NA ATHL1 HGNC:26210 ATH1, acid trehalase-like 1 (yeast) Q32M88 vacuole 14 0 vacuole vacuole Deuterostomia Cell.Organisms Cell.Organisms ATIC HGNC:794 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase P31939 cytoplasm 42 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ATL1 HGNC:11231 atlastin GTPase 1 Q8WXF7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, axon (By similarity). Golgi apparatus (GO:0005794) 14506257 endoplasmic reticulum membrane 65 2 endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Bilateria Bilateria Eukaryota ATL2 HGNC:24047 atlastin GTPase 2 Q8NHH9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 17081983 endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane. nucleus multiple Bilateria Bilateria Eukaryota ATL3 HGNC:24526 atlastin GTPase 3 Q6DD88 Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 15598749 endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane. mitochondrion multiple Bilateria Bilateria Eukaryota ATM HGNC:795 ataxia telangiectasia mutated Q13315 Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. Nucleus (GO:0005634); Peroxisome (GO:0005777); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microsome (GO:0005792) 10567403,16293623,16221682,15561729,10567403,10567403,15635413,16221682 nucleus 11 0 cytoplasm. nucleus. peroxisome multiple Opisthokonta Eukaryota Eukaryota ATMIN HGNC:29034 ATM interactor O43313 Nucleus. Note=Nuclear, in discrete foci during G1 phase. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ATN1 HGNC:3033 atrophin 1 P54259 Nucleus. Cytoplasm, perinuclear region. Cell junction (By similarity). Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity). Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Asn (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7647802,12464607,17081983,10814707,12464607,17081983 nucleus 36 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi NA ATOH1 HGNC:797 atonal homolog 1 (Drosophila) Q92858 Nucleus (Probable). Nucleus (GO:0005634) 9449674 nucleus 86 0 nucleus nucleus Theria Bilateria Metazoa ATOH7 HGNC:13907 atonal homolog 7 (Drosophila) Q8N100 Nucleus (Probable). Nucleus (GO:0005634) 11889557 nucleus 62 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa ATOH8 HGNC:24126 atonal homolog 8 (Drosophila) Q96SQ7 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 86 0 nucleus nucleus Deuterostomia Bilateria Metazoa ATOX1 HGNC:798 antioxidant 1 copper chaperone O00244 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10497213,10557326,10557326 cytoplasm 30 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota ATP10A HGNC:13542 ATPase, class V, type 10A O60312 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B. Plasma membrane (GO:0005886) 11015572 golgi apparatus membrane 21 10 plasma membrane plasma membrane Eukaryota Eukaryota Cell.Organisms ATP10B HGNC:13543 ATPase, class V, type 10B O94823 Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. Plasma membrane (GO:0005886) 11015572 golgi apparatus membrane 27 10 plasma membrane plasma membrane Eukaryota Eukaryota Cell.Organisms ATP10D HGNC:13549 ATPase, class V, type 10D Q9P241 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B. Plasma membrane (GO:0005886) 12532265 plasma membrane 25 10 plasma membrane plasma membrane Eukaryota Eukaryota Cell.Organisms ATP11A HGNC:13552 ATPase, class VI, type 11A P98196 Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane. Integral to membrane (GO:0016021) 15533723 golgi apparatus membrane 23 10 endoplasmic reticulum. endosome. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms ATP11AUN HGNC:33793 ATP11A upstream neighbor Q6ZP68 secreted 68 0 secreted secreted Homininae Homininae Primates ATP11B HGNC:13553 ATPase, class VI, type 11B Q9Y2G3 Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes. Plasma membrane (GO:0005886) 11015572 golgi apparatus membrane 25 10 endoplasmic reticulum. endosome. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms ATP11C HGNC:13554 ATPase, class VI, type 11C Q8NB49 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B. golgi apparatus membrane 22 10 plasma membrane plasma membrane Eukaryota Eukaryota Cell.Organisms ATP12A HGNC:13816 ATPase, H+/K+ transporting, nongastric, alpha polypeptide P54707 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8838794 plasma membrane 56 10 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ATP13A1 HGNC:24215 ATPase type 13A1 Q9HD20 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,17081983 endoplasmic reticulum membrane 28 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Cell.Organisms ATP13A2 HGNC:30213 ATPase type 13A2 Q9NQ11 Membrane; Multi-pass membrane protein (By similarity). Lysosome. vacuole membrane 21 11 lysosome lysosome Opisthokonta Eukaryota Cell.Organisms ATP13A3 HGNC:24113 ATPase type 13A3 Q9H7F0 Membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634) 17081983 vacuole membrane 25 11 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms ATP13A4 HGNC:25422 ATPase type 13A4 Q4VNC1 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) vacuole membrane 20 11 vacuole membrane vacuole membrane Opisthokonta Eukaryota Cell.Organisms ATP13A5 HGNC:31789 ATPase type 13A5 Q4VNC0 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 19 11 vacuole membrane vacuole membrane Opisthokonta Eukaryota Cell.Organisms ATP1A1 HGNC:799 ATPase, Na+/K+ transporting, alpha 1 polypeptide P05023 Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Mitochondrion (GO:0005739) 12031509,15561729,15598749 plasma membrane 91 10 melanosome. mitochondrion. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ATP1A2 HGNC:800 ATPase, Na+/K+ transporting, alpha 2 polypeptide P50993 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12805306 plasma membrane 86 10 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ATP1A3 HGNC:801 ATPase, Na+/K+ transporting, alpha 3 polypeptide P13637 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2842249 plasma membrane 100 10 plasma membrane plasma membrane Eukaryota Cell.Organisms NA ATP1A4 HGNC:14073 ATPase, Na+/K+ transporting, alpha 4 polypeptide Q13733 Cell membrane; Multi-pass membrane protein. Note=In mature sperm, located in the principle piece of the sperm flagellum. Plasma membrane (GO:0005886) 12763850 plasma membrane 100 10 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ATP1B1 HGNC:804 ATPase, Na+/K+ transporting, beta 1 polypeptide P05026 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 11193188 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa ATP1B2 HGNC:805 ATPase, Na+/K+ transporting, beta 2 polypeptide P14415 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 11193188 plasma membrane 100 1 plasma membrane plasma membrane Theria Bilateria Eumetazoa ATP1B3 HGNC:806 ATPase, Na+/K+ transporting, beta 3 polypeptide P54709 Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886) 8798450,6289898 plasma membrane 37 1 melanosome. plasma membrane multiple Euteleostomi Euteleostomi Holozoa ATP1B4 HGNC:808 ATPase, Na+/K+ transporting, beta 4 polypeptide Q9UN42 Nucleus inner membrane; Single-pass type II membrane protein (By similarity). Note=Detected in nuclear envelops. Plasma membrane (GO:0005886) nucleus membrane 90 1 nucleus membrane nucleus membrane Euteleostomi Euteleostomi Eumetazoa ATP2A1 HGNC:811 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 O14983 Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum (GO:0016529); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Mitochondrion (GO:0005739) 14638697,14638697,16188874,15598749 endoplasmic reticulum membrane 100 10 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. secreted multiple Eukaryota Cell.Organisms Cell.Organisms ATP2A2 HGNC:812 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 P16615 Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10441324,15561729,10441324,15598749/17081983,17081983 endoplasmic reticulum membrane 100 10 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ATP2A3 HGNC:813 ATPase, Ca++ transporting, ubiquitous Q93084 Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Sarcoplasmic reticulum (GO:0016529); Nuclear membrane (GO:0005635); Mitochondrion (GO:0005739) 8809064,9843705,8809064,9843705,15598749 endoplasmic reticulum membrane 71 10 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. nucleus membrane multiple Eukaryota Cell.Organisms Cell.Organisms ATP2B1 HGNC:814 ATPase, Ca++ transporting, plasma membrane 1 P20020 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1674727,15598749,17081983,17081983 plasma membrane 100 10 cytoplasm. mitochondrion. nucleus. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ATP2B2 HGNC:815 ATPase, Ca++ transporting, plasma membrane 2 Q01814 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1313367 plasma membrane 100 10 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms ATP2B3 HGNC:816 ATPase, Ca++ transporting, plasma membrane 3 Q16720 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8765088 plasma membrane 100 10 plasma membrane plasma membrane Eukaryota Cell.Organisms NA ATP2B4 HGNC:817 ATPase, Ca++ transporting, plasma membrane 4 P23634 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Basolateral membrane (GO:0016323);Plasma membrane (GO:0005886); Nucleus (GO:0005634) 15145946,15145946,11274188/1674727,17081983 plasma membrane 100 10 cytoplasm. nucleus. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ATP2C1 HGNC:13211 ATPase, Ca++ transporting, type 2C, member 1 P98194 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 10615129 golgi apparatus membrane 100 10 golgi apparatus. golgi apparatus membrane multiple Eukaryota Cell.Organisms Cell.Organisms ATP2C2 HGNC:29103 ATPase, Ca++ transporting, type 2C, member 2 O75185 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 59 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Cell.Organisms Cell.Organisms ATP4A HGNC:819 ATPase, H+/K+ exchanging, alpha polypeptide P20648 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 2160952,2160952 plasma membrane 100 10 cytoplasm. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms ATP4B HGNC:820 ATPase, H+/K+ exchanging, beta polypeptide P51164 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 2160952,2160952 plasma membrane 100 1 cytoplasm. plasma membrane multiple Tetrapoda Tetrapoda Eumetazoa ATP5A1 HGNC:823 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle P25705 Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Colocalizes with HRG on the cell surface of T-cells. Mitochondrion (GO:0005739); Extracellular (GO:0005576); Zymogen granule (GO:0042588);Mitochondrion (GO:0005739) 1830491,17510655,15598749,16188874,16278343/1830491 mitochondrion 56 0 mitochondrion. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms ATP5B HGNC:830 ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide P06576 Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Extracellular (GO:0005576); Zymogen granule (GO:0042588) 12511957,15033988,15598749,10077593,15635413,11790298,16188874,16278343 mitochondrion 52 0 mitochondrion. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms ATP5C1 HGNC:833 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 P36542 Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (By similarity). Mitochondrion (GO:0005739) 8227057,15598749 mitochondrion 45 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ATP5D HGNC:837 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit P30049 Mitochondrion. Mitochondrion inner membrane. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 1531933,11533724,15598749 mitochondrion 83 0 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms ATP5E HGNC:838 ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit P56381 Mitochondrion. Mitochondrion inner membrane. Mitochondrial membrane (GO:0005740) 10727396,9461222 mitochondrion 53 0 mitochondrion. mitochondrion membrane multiple Amniota Eukaryota Opisthokonta ATP5F1 HGNC:840 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 P24539 Mitochondrion. Mitochondrion inner membrane. Mitochondrion (GO:0005739) 1831354,15598749 mitochondrion 40 0 mitochondrion mitochondrion Bilateria Bilateria Opisthokonta ATP5G1 HGNC:841 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) P05496 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrial membrane (GO:0005740) 9834036 mitochondrion membrane 100 2 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Cell.Organisms ATP5G2 HGNC:842 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) Q06055 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 7698763,2883974,8328972/8328972 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms ATP5G3 HGNC:843 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) P48201 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 7698763 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms ATP5H HGNC:845 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d O75947 Mitochondrion. Mitochondrion inner membrane. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 7509337,15598749 cytoplasm 40 0 mitochondrion. mitochondrion membrane multiple Opisthokonta Opisthokonta Eukaryota ATP5I HGNC:846 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E P56385 Mitochondrion. Mitochondrion inner membrane. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 8702853,16188874 cytoplasm 28 1 mitochondrion. secreted multiple Tetrapoda Euteleostomi Bilateria ATP5J HGNC:847 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 P18859 Mitochondrion. Mitochondrion inner membrane. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 1830479,1825642,14633154 mitochondrion 82 0 mitochondrion. secreted multiple Deuterostomia Bilateria Eumetazoa ATP5J2 HGNC:848 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 P56134 Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein (Potential). Mitochondrion (GO:0005739) 11959398 mitochondrion 15 1 mitochondrion mitochondrion NA NA Bilateria ATP5L HGNC:14247 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G O75964 Mitochondrion. Mitochondrion inner membrane. Mitochondrion (GO:0005739) none,15598749 mitochondrion 19 1 mitochondrion mitochondrion Bilateria Bilateria NA ATP5L2 HGNC:13213 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2 Q7Z4Y8 Mitochondrion membrane (By similarity). mitochondrion 21 0 mitochondrion mitochondrion NA NA Holozoa ATP5O HGNC:850 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit P48047 Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739) 12110673 mitochondrion 75 0 mitochondrion mitochondrion NA NA Cell.Organisms ATP5S HGNC:18799 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) Q99766 Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739) 6143319 nucleus 80 0 mitochondrion mitochondrion Bilateria Bilateria Holozoa ATP5SL HGNC:25496 ATP5S-like Q9NW81 cytoplasm 17 0 cytoplasm cytoplasm Eutheria Bilateria NA ATP6AP1 HGNC:868 ATPase, H+ transporting, lysosomal accessory protein 1 Q15904 Vacuole membrane; Single-pass membrane protein (By similarity). vacuole membrane 81 1 vacuole membrane vacuole membrane Deuterostomia Bilateria NA ATP6AP1L HGNC:28091 ATPase, H+ transporting, lysosomal accessory protein 1-like Q52LC2 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 31 1 vacuole membrane vacuole membrane Theria Euteleostomi Euteleostomi ATP6AP2 HGNC:18305 ATPase, H+ transporting, lysosomal accessory protein 2 O75787 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12045255 plasma membrane 46 1 plasma membrane plasma membrane Bilateria Bilateria Metazoa ATP6V0A1 HGNC:865 ATPase, H+ transporting, lysosomal V0 subunit a1 Q93050 Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Brush border (GO:0005903); Zymogen granule (GO:0042588); Mitochondrion (GO:0005739) 16415858,16278343,15598749 plasma membrane 53 7 melanosome. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms ATP6V0A2 HGNC:18481 ATPase, H+ transporting, lysosomal V0 subunit a2 Q9Y487 Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles (By similarity). Integral to membrane (GO:0016021); Early endosome (GO:0005769); Nucleus (GO:0005634) ,16415858,17081983 plasma membrane 44 7 endosome. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms ATP6V0A4 HGNC:866 ATPase, H+ transporting, lysosomal V0 subunit a4 Q9HBG4 Apical cell membrane; Multi-pass membrane protein. Note=Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Brush border (GO:0005903) 10973252,10973252,16415858 plasma membrane 100 7 cytoplasm. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms ATP6V0B HGNC:861 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b Q99437 Vacuole membrane; Multi-pass membrane protein. vacuole membrane 100 5 vacuole membrane vacuole membrane Eukaryota Eukaryota Cell.Organisms ATP6V0C HGNC:855 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c P27449 Vacuole membrane; Multi-pass membrane protein. Lysosome (GO:0005764); Plasma membrane (GO:0005886); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12438748,8250920,10221984,10221984,10440860,8250920,10221984,10440860,8250920,12438748,10221984,8250920,10221984,8250920 vacuole membrane 100 4 endoplasmic reticulum. endosome. golgi apparatus. lysosome. plasma membrane. vacuole membrane multiple Eukaryota Eukaryota Cell.Organisms ATP6V0D1 HGNC:13724 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 P61421 Membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Localizes to centrosome and the base of the cilium. cytoplasm 31 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATP6V0D2 HGNC:18266 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 Q8N8Y2 Integral to membrane (GO:0016021) 14580332,12788495 cytoplasm 29 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ATP6V0E1 HGNC:863 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 O15342 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 9556572 vacuole membrane 43 2 plasma membrane plasma membrane Bilateria Eukaryota Opisthokonta ATP6V0E2 HGNC:21723 ATPase, H+ transporting V0 subunit e2 Q8NHE4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 60 2 vacuole membrane vacuole membrane Bilateria Eukaryota Opisthokonta ATP6V1A HGNC:851 ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A P38606 Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endosome (GO:0005768); Secretory vesicle (None) 8463241,11836511,11836511,16415858,11836511 cytoplasm 41 0 endosome. lysosome multiple Cell.Organisms Cell.Organisms Cell.Organisms ATP6V1B1 HGNC:853 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 P15313 Endomembrane system; Peripheral membrane protein. Note=Endomembrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Lysosome (GO:0005764); Golgi apparatus (GO:0005794); Secretory granule (GO:0030141); Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783) 10915794,10221984,10915794,10221984,10221984,10221984,10221984,10221984 cytoplasm 32 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome multiple Cell.Organisms Cell.Organisms NA ATP6V1B2 HGNC:854 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 P21281 Endomembrane system; Peripheral membrane protein. Melanosome. Note=Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endosome (GO:0005768) 12670943,16415858 mitochondrion 15 0 endosome. melanosome multiple Cell.Organisms Cell.Organisms Cell.Organisms ATP6V1C1 HGNC:856 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 P21283 cytoplasm 46 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATP6V1C2 HGNC:18264 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 Q8NEY4 cytoplasm 38 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota ATP6V1D HGNC:13527 ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D Q9Y5K8 Membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Localizes to centrosome and the base of the cilium. Integral to membrane (GO:0016021); Cytosol (GO:0005829) ,15561729 nucleus 52 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms ATP6V1E1 HGNC:857 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 P36543 Plasma membrane (GO:0005886); Endosome (GO:0005768); Lysosome (GO:0005764); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 10221984,10440860,8250920,10221984,16415858,8250920,10221984,10221984,10221984,10915794 cytoplasm 37 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome multiple Eukaryota Cell.Organisms Eukaryota ATP6V1E2 HGNC:18125 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 Q96A05 Integral to membrane (GO:0016021) cytoplasm 33 0 cytoplasm cytoplasm NA NA Eukaryota ATP6V1F HGNC:16832 ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F Q16864 Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 9442887,15598749 mitochondrion 13 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms ATP6V1G1 HGNC:864 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 O75348 Lysosome (GO:0005764) cytoplasm 45 0 cytoplasm cytoplasm Eukaryota Eukaryota Opisthokonta ATP6V1G2 HGNC:862 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 O95670 Melanosome. Note=Highly enriched in late- stage melanosomes. cytoplasm 44 0 melanosome melanosome Eukaryota Eukaryota NA ATP6V1G3 HGNC:18265 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 Q96LB4 Plasma membrane (GO:0005886) 1415677,11836511 cytoplasm 42 0 cytoplasm cytoplasm Tetrapoda Tetrapoda NA ATP6V1H HGNC:18303 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H Q9UI12 nucleus 55 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ATP7A HGNC:869 ATPase, Cu++ transporting, alpha polypeptide Q04656 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Isoform 3: Cytoplasm, cytosol (Probable). Isoform 5: Endoplasmic reticulum. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 9817923,9817923,9467005,14718574 golgi apparatus membrane 27 8 cytoplasm. endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. plasma membrane. secreted multiple Cell.Organisms Cell.Organisms NA ATP7B HGNC:870 ATPase, Cu++ transporting, beta polypeptide P35670 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein (By similarity). Isoform 2: Cytoplasm. WND/140 kDa: Mitochondrion. Cytoplasm (GO:0005737);Golgi apparatus (GO:0005794); Endosome (GO:0005768); Mitochondrion (GO:0005739);Golgi apparatus (GO:0005794) 9307043/9724794,9307043,12579329,9600907/9307043 golgi apparatus membrane 22 8 cytoplasm. endosome. golgi apparatus. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms ATP8A1 HGNC:13531 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Q9Y2Q0 Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein (By similarity). Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures. Integral to membrane (GO:0016021) golgi apparatus membrane 34 10 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Cell.Organisms ATP8A2 HGNC:13533 ATPase, aminophospholipid transporter, class I, type 8A, member 2 Q9NTI2 Membrane; Multi-pass membrane protein. golgi apparatus membrane 33 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Cell.Organisms ATP8B1 HGNC:3706 ATPase, aminophospholipid transporter, class I, type 8B, member 1 O43520 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B. golgi apparatus membrane 25 10 endoplasmic reticulum. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms ATP8B2 HGNC:13534 ATPase, aminophospholipid transporter, class I, type 8B, member 2 P98198 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) golgi apparatus membrane 27 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Cell.Organisms ATP8B3 HGNC:13535 ATPase, aminophospholipid transporter, class I, type 8B, member 3 O60423 Membrane; Multi-pass membrane protein. golgi apparatus membrane 25 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Cell.Organisms ATP8B4 HGNC:13536 ATPase, class I, type 8B, member 4 Q8TF62 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 26 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Cell.Organisms ATP9A HGNC:13540 ATPase, class II, type 9A O75110 Early endosome membrane; Multi-pass membrane protein. Recycling endosome. Golgi apparatus, trans-Golgi network membrane. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. golgi apparatus membrane 71 10 endosome endosome Eukaryota Eukaryota Cell.Organisms ATP9B HGNC:13541 ATPase, class II, type 9B O43861 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. Integral to membrane (GO:0016021) golgi apparatus membrane 100 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota NA ATPAF1 HGNC:18803 ATP synthase mitochondrial F1 complex assembly factor 1 Q5TC12 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12206899,11410595 mitochondrion 17 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota ATPAF2 HGNC:18802 ATP synthase mitochondrial F1 complex assembly factor 2 Q8N5M1 Mitochondrion (Probable). Mitochondrion (GO:0005739) 11410595 mitochondrion 14 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ATPIF1 HGNC:871 ATPase inhibitory factor 1 Q9UII2 Mitochondrion. Mitochondrion (GO:0005739); Nucleolus (GO:0005730); Plasma membrane (GO:0005886) 10664857,15809073,15598749,15635413,15809073 mitochondrion 100 0 mitochondrion. nucleus multiple Bilateria Bilateria Metazoa ATR HGNC:882 ataxia telangiectasia and Rad3 related Q13535 Nucleus. Nucleus, PML body (By similarity). Chromosome (By similarity). Note=Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling. Nucleus (GO:0005634); Nucleolus (GO:0005730) 14724280,11721054,11278964,15635413,11790298 nucleus 100 2 nucleus nucleus Eukaryota Eukaryota Eukaryota ATRAID HGNC:24090 all-trans retinoic acid-induced differentiation factor Q6UW56 Nucleus envelope. Cell membrane; Single-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region. plasma membrane 34 1 plasma membrane plasma membrane Chordata Chordata Eumetazoa ATRIP HGNC:33499 ATR interacting protein Q8WXE1 Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage. nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa ATRN HGNC:885 attractin O75882 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Plasma membrane (GO:0005886);Extracellular (GO:0005576) 10811918/9736737 secreted 28 5 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms ATRNL1 HGNC:29063 attractin-like 1 Q5VV63 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 32 5 n/a n/a Bilateria Eukaryota Cell.Organisms ATRX HGNC:886 alpha thalassemia/mental retardation syndrome X-linked P46100 Nucleus. Note=Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with HP1. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9499421,17081983,15635413,15065660,17081983/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota NA ATXN1 HGNC:10548 ataxin 1 P54253 Cytoplasm (By similarity). Nucleus. Note=Colocalizes with USP7 in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7647801,17110330,7647801 nucleus 15 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa ATXN10 HGNC:10549 ataxin 10 Q9UBB4 Cytoplasm, perinuclear region. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota ATXN1L HGNC:33279 ataxin 1-like P0C7T5 Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells. nucleus 23 0 nucleus nucleus NA NA Eumetazoa ATXN2 HGNC:10555 ataxin 2 Q99700 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9989626,11471052,15663938,17000644 cytoplasm 87 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota ATXN2L HGNC:31326 ataxin 2-like Q8WWM7 Membrane; Peripheral membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytosol (GO:0005829); Cytoplasm (GO:0005737) 17081983,17081983/15302935,17000644,17081983,15561729,17081983 cytoplasm 35 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota ATXN3 HGNC:7106 ataxin 3 P54252 Nucleus matrix. Note=Predominantly nuclear, but not exclusively, inner nuclear matrix. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9580663,9124802,9580663,9124802 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota ATXN3L HGNC:24173 ataxin 3-like Q9H3M9 Nucleus (By similarity). nucleus 65 0 nucleus nucleus Human Catarrhini Eukaryota ATXN7 HGNC:10560 ataxin 7 O15265 Isoform a: Nucleus. Nucleus, nucleolus. Nucleus matrix. Cytoplasm, cytoskeleton. Isoform b: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11709544,15115762,11709544,10441328 nucleus 20 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Opisthokonta ATXN7L1 HGNC:22210 ataxin 7-like 1 Q9ULK2 nucleus 24 0 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta ATXN7L2 HGNC:28713 ataxin 7-like 2 Q5T6C5 cytoplasm 19 0 cytoplasm cytoplasm Mammalia Euteleostomi Opisthokonta ATXN7L3 HGNC:25416 ataxin 7-like 3 Q14CW9 Nucleus (Probable). nucleus 97 0 nucleus nucleus Chordata Eukaryota Eukaryota ATXN7L3B HGNC:37931 ataxin 7-like 3B Q96GX2 nucleus 33 0 nucleus nucleus NA NA Craniata ATXN8 HGNC:32925 ataxin 8 Q156A1 Nucleus. Note=Present in SCA8-specific 1C2- positive intranuclear inclusions. nucleus 100 0 nucleus nucleus NA NA NA AUH HGNC:890 AU RNA binding protein/enoyl-CoA hydratase Q13825 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 10072761 mitochondrion 93 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms AUNIP HGNC:28363 aurora kinase A and ninein interacting protein Q9H7T9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the centrosome in interphase and to the spindle pole in metaphase. cytoplasm 100 0 cytoplasm cytoplasm Theria Theria Mammalia AUP1 HGNC:891 ancient ubiquitous protein 1 Q9Y679 Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737) 12534238 secreted 8 5 cytoplasm. endoplasmic reticulum membrane multiple Deuterostomia Eukaryota Metazoa AURKA HGNC:11393 aurora kinase A O14965 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. Centrosome (GO:0005813); Mitochondrion (GO:0005739) 9153231,15561729 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms AURKAIP1 HGNC:24114 aurora kinase A interacting protein 1 Q9NWT8 Nucleus. Nucleus (GO:0005634) 12244051 nucleus 49 0 nucleus nucleus Amniota Euteleostomi Craniata AURKB HGNC:11390 aurora kinase B Q96GD4 Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid- body. Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Centrosome (GO:0005813); Nucleolus (GO:0005730); Chromosome (GO:0005694); Mitochondrion (GO:0005739) 9514916,15635413,17113138,17099693,15561729 nucleus 62 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms AURKC HGNC:11391 aurora kinase C Q9UQB9 Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. Centrosome (GO:0005813) 10066797 nucleus 60 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms AUTS2 HGNC:14262 autism susceptibility candidate 2 Q8WXX7 nucleus 18 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria AVEN HGNC:13509 apoptosis, caspase activation inhibitor Q9NQS1 Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes. Nucleus (GO:0005634); Integral to membrane (GO:0016021) 10949025,10949025 nucleus 85 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria AVIL HGNC:14188 advillin O75366 Cytoplasm, cytoskeleton. Cell projection (By similarity). Cell projection, axon (By similarity). Cytoskeleton (GO:0005856) 15561729 cytoplasm 37 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota AVL9 HGNC:28994 AVL9 homolog (S. cerevisiase) Q8NBF6 Recycling endosome. Membrane; Single-pass membrane protein (Potential). cytoplasm 22 1 endosome endosome Opisthokonta Eukaryota Eukaryota AVP HGNC:894 arginine vasopressin P01185 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634) 11713645,11384615 secreted 100 0 nucleus. secreted multiple Euteleostomi Euteleostomi Bilateria AVPI1 HGNC:30898 arginine vasopressin-induced 1 Q5T686 nucleus 84 0 nucleus nucleus Human Tetrapoda Euteleostomi AVPR1A HGNC:895 arginine vasopressin receptor 1A P37288 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8838314 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Metazoa AVPR1B HGNC:896 arginine vasopressin receptor 1B P47901 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7805841 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Chordata NA AVPR2 HGNC:897 arginine vasopressin receptor 2 P30518 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9224808 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi NA AWAT1 HGNC:23252 acyl-CoA wax alcohol acyltransferase 1 Q58HT5 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 45 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Tetrapoda Eukaryota AWAT2 HGNC:23251 acyl-CoA wax alcohol acyltransferase 2 Q6E213 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Eukaryota AXDND1 HGNC:26564 axonemal dynein light chain domain containing 1 Q5T1B0 cytoplasm 18 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota AXIN1 HGNC:903 axin 1 O15169 Cytoplasm. Nucleus. Membrane (By similarity). Cell membrane (By similarity). Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12072559,14630927,12138115,12072559,14970870,14630927,16601693,12138115,12072559 cytoplasm 33 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota AXIN2 HGNC:904 axin 2 Q9Y2T1 Cytoplasm. Nucleus (GO:0005634) 12072559 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota AXL HGNC:905 AXL receptor tyrosine kinase P30530 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11290560,7822279,7822279 plasma membrane 100 1 plasma membrane. secreted multiple Chordata Chordata Cell.Organisms AZGP1 HGNC:910 alpha-2-glycoprotein 1, zinc-binding P25311 Secreted. Extracellular (GO:0005576) 10462714,16188874 secreted 100 0 secreted secreted Theria Theria Craniata AZI2 HGNC:24002 5-azacytidine induced 2 Q9H6S1 Cytoplasm. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14560022/17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Chordata AZIN1 HGNC:16432 antizyme inhibitor 1 O14977 mitochondrion 32 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Cell.Organisms AZU1 HGNC:913 azurocidin 1 P20160 Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils. Cytoplasmic vesicle (GO:0016023); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11861296,2332502,12135665,11861296,10510329,10510329 cytoplasm 100 0 mitochondrion. nucleus. secreted multiple Catarrhini Catarrhini Cell.Organisms B2M HGNC:914 beta-2-microglobulin P61769 Secreted. Note=Detected in serum and urine. Extracellular (GO:0005576) 3048575,12006623 secreted 100 0 secreted secreted Amniota Euteleostomi Craniata B3GALNT1 HGNC:918 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) O75752 Golgi apparatus membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10993897,6425294 golgi apparatus membrane 100 0 endoplasmic reticulum. golgi apparatus membrane multiple Amniota Amniota Eukaryota B3GALNT2 HGNC:28596 beta-1,3-N-acetylgalactosaminyltransferase 2 Q8NCR0 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) 14724282 golgi apparatus membrane 12 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Eukaryota B3GALT1 HGNC:916 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 Q9Y5Z6 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Golgi apparatus (GO:0005794) 9417100 golgi apparatus membrane 27 0 golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Eukaryota B3GALT2 HGNC:917 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 O43825 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Golgi apparatus (GO:0005794) 9417100 golgi apparatus membrane 20 1 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Euteleostomi Eukaryota B3GALT4 HGNC:919 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 O96024 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi NA B3GALT5 HGNC:920 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 Q9Y2C3 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) 10212226 golgi apparatus membrane 24 0 golgi apparatus membrane golgi apparatus membrane Tetrapoda Bilateria Eukaryota B3GALT6 HGNC:17978 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 Q96L58 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11551958,11551958 golgi apparatus membrane 100 0 cytoplasm. golgi apparatus. golgi apparatus membrane multiple Bilateria Bilateria Eukaryota B3GALTL HGNC:20207 beta 1,3-galactosyltransferase-like Q6Y288 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) 12943678 endoplasmic reticulum membrane 100 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Metazoa B3GAT1 HGNC:921 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Q9P2W7 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 10783264,10946001 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Euteleostomi Eukaryota B3GAT2 HGNC:922 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) Q9NPZ5 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Eukaryota B3GAT3 HGNC:923 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) O94766 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network. Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 10842173,10842173 golgi apparatus membrane 94 1 golgi apparatus. golgi apparatus membrane. secreted multiple Bilateria Bilateria Eukaryota B3GNT1 HGNC:15685 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 O43505 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Mammalia Bilateria Eukaryota B3GNT2 HGNC:15629 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Q9NY97 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) 11042166 golgi apparatus membrane 28 0 golgi apparatus membrane golgi apparatus membrane Chordata Chordata Eukaryota B3GNT3 HGNC:13528 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Q9Y2A9 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) golgi apparatus membrane 44 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Bilateria Eukaryota B3GNT4 HGNC:15683 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Q9C0J1 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 32 2 golgi apparatus membrane golgi apparatus membrane Mammalia Tetrapoda Eukaryota B3GNT5 HGNC:15684 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Q9BYG0 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 22 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eukaryota B3GNT6 HGNC:24141 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase) Q6ZMB0 Golgi apparatus membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) 11821425 golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Bilateria NA B3GNT7 HGNC:18811 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 Q8NFL0 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 31 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eukaryota B3GNT8 HGNC:24139 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 Q7Z7M8 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) 15620693 golgi apparatus membrane 24 0 golgi apparatus membrane golgi apparatus membrane Theria Theria Eumetazoa B3GNT9 HGNC:28714 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Q6UX72 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 28 0 golgi apparatus membrane golgi apparatus membrane NA NA Eukaryota B3GNTL1 HGNC:21727 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 Q67FW5 cytoplasm 27 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms B4GALNT1 HGNC:4117 beta-1,4-N-acetyl-galactosaminyl transferase 1 Q00973 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 8824296,10477274,10477274 golgi apparatus membrane 100 0 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane multiple Theria Euteleostomi Cell.Organisms B4GALNT2 HGNC:24136 beta-1,4-N-acetyl-galactosaminyl transferase 2 Q8NHY0 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 11886838,12678917,11886838 golgi apparatus membrane 68 1 golgi apparatus. plasma membrane multiple Mammalia Mammalia Cell.Organisms B4GALNT3 HGNC:24137 beta-1,4-N-acetyl-galactosaminyl transferase 3 Q6L9W6 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes to apical Golgi. Extracellular (GO:0005576) 12966086 golgi apparatus membrane 100 0 golgi apparatus membrane. secreted multiple Amniota Euteleostomi Cell.Organisms B4GALNT4 HGNC:26315 beta-1,4-N-acetyl-galactosaminyl transferase 4 Q76KP1 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 40 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms B4GALT1 HGNC:924 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 P15291 Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cell surface. Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Processed beta-1,4-galactosyltransferase 1: Secreted. Note=Soluble form found in body fluids. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 1384956,1384956,8540625 golgi apparatus membrane 48 1 golgi apparatus. golgi apparatus membrane. plasma membrane. secreted multiple Chordata Bilateria Cell.Organisms B4GALT2 HGNC:925 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 O60909 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. Golgi membrane (GO:0000139) 9405390,9597550 golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Bilateria Cell.Organisms B4GALT3 HGNC:926 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 O60512 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. Golgi apparatus (GO:0005794) 9405390,9597550 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Bilateria Cell.Organisms B4GALT4 HGNC:927 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 O60513 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. Golgi membrane (GO:0000139) 9597550,9792633 golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms B4GALT5 HGNC:928 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 O43286 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. Golgi apparatus (GO:0005794) golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Cell.Organisms B4GALT6 HGNC:929 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 Q9UBX8 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. Golgi apparatus (GO:0005794) golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Cell.Organisms B4GALT7 HGNC:930 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 Q9UBV7 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Cis cisternae of Golgi stack. Golgi apparatus (GO:0005794) 10473568 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Bilateria Bilateria Cell.Organisms B9D1 HGNC:24123 B9 protein domain 1 Q9UPM9 Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota B9D2 HGNC:28636 B9 protein domain 2 Q9BPU9 Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Nucleus (By similarity). cytoplasm 15 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota BAALC HGNC:14333 brain and acute leukemia, cytoplasmic Q8WXS3 Cytoplasm. Membrane. Note=Postsynaptic lipid rafts (By similarity). Cytoplasm (GO:0005737) 11707601 nucleus 27 0 cytoplasm cytoplasm Theria Euteleostomi Euteleostomi BAAT HGNC:932 bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) Q14032 Cytoplasm. Cytoplasm (GO:0005737); Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 8034703,2037576,12810727,10884298,10884298 cytoplasm 100 0 cytoplasm. mitochondrion. peroxisome multiple Tetrapoda Bilateria Cell.Organisms BABAM1 HGNC:25008 BRISC and BRCA1 A complex member 1 Q9NWV8 Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). nucleus 62 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota BACE1 HGNC:933 beta-site APP-cleaving enzyme 1 P56817 Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Endosome (GO:0005768); Lysosome (GO:0005764) 11466313,11152683,10887202,11152683,11466313,11152683,11466313,10887202,10677483,11466313,10677483 vacuole 9 1 endoplasmic reticulum. endosome. golgi apparatus. lysosome. plasma membrane multiple Deuterostomia Deuterostomia Eukaryota BACE2 HGNC:934 beta-site APP-cleaving enzyme 2 Q9Y5Z0 Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endosome (GO:0005768); Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11423558,11423558,11423558,10749877,11423558,11423558 secreted 24 1 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota BACH1 HGNC:935 BTB and CNC homology 1, basic leucine zipper transcription factor 1 O14867 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11069897,11069897 nucleus 31 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota BACH2 HGNC:14078 BTB and CNC homology 1, basic leucine zipper transcription factor 2 Q9BYV9 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15060166,10809773,11923289,15060166,10809773,11923289 nucleus 25 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota BAD HGNC:936 BCL2-associated agonist of cell death Q92934 Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 15849194,10949026,12657644,16413544,12657644,10949026,16413544 nucleus 67 0 cytoplasm. mitochondrion multiple Eutheria Euteleostomi Euteleostomi BAG1 HGNC:937 BCL2-associated athanogene Q99933 Isoform 1: Nucleus. Cytoplasm. Isoform 2: Cytoplasm. Nucleus. Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9679980,14517289,9679980 nucleus 9 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Holozoa BAG2 HGNC:938 BCL2-associated athanogene 2 O95816 Nucleus (GO:0005634); Cytosol (GO:0005829) 9873016,15561729 cytoplasm 33 0 cytoplasm. nucleus multiple Bilateria Bilateria Bilateria BAG3 HGNC:939 BCL2-associated athanogene 3 O95817 Cytoplasm (GO:0005737) 10597216,17081983 cytoplasm 62 0 cytoplasm cytoplasm Amniota Chordata Eukaryota BAG4 HGNC:940 BCL2-associated athanogene 4 O95429 Cytoplasm. Cytoplasm (GO:0005737) 12017295 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa BAG5 HGNC:941 BCL2-associated athanogene 5 Q9UL15 cytoplasm 27 0 cytoplasm cytoplasm Human Human Eumetazoa BAG6 HGNC:13919 BCL2-associated athanogene 6 P46379 Cytoplasm, cytosol. Nucleus. Note=The C- terminal fragment generated by caspase-3 is cytoplasmic. Also found in extracellular vesicular exosomes in some tumor cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 11587531,17403783,17081983,10390159,17081983,17403783 nucleus 22 2 cytoplasm. nucleus multiple Theria Eukaryota NA BAGE HGNC:942 B melanoma antigen Q13072 Secreted (Potential). secreted 66 0 secreted secreted NA NA NA BAGE2 HGNC:15723 B melanoma antigen family, member 2 Q86Y30 Secreted (Potential). secreted 68 0 secreted secreted Human Human NA BAGE3 HGNC:15728 B melanoma antigen family, member 3 Q86Y29 Secreted (Potential). secreted 65 0 secreted secreted NA NA NA BAGE4 HGNC:15730 B melanoma antigen family, member 4 Q86Y28 Secreted (Potential). secreted 62 0 secreted secreted NA NA NA BAGE5 HGNC:15732 B melanoma antigen family, member 5 Q86Y27 Secreted (Potential). secreted 67 0 secreted secreted NA NA NA BAHCC1 HGNC:29279 BAH domain and coiled-coil containing 1 Q9P281 Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota BAHD1 HGNC:29153 bromo adjacent homology domain containing 1 Q8TBE0 Nucleus. Chromosome. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3). nucleus 100 0 nucleus nucleus Chordata Bilateria Eukaryota BAI1 HGNC:943 brain-specific angiogenesis inhibitor 1 O14514 Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sites. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12074842,12074842,12543931 plasma membrane 100 7 cytoplasm. plasma membrane. secreted multiple Euteleostomi Euteleostomi Eukaryota BAI2 HGNC:944 brain-specific angiogenesis inhibitor 2 O60241 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) ,12543931 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota BAI3 HGNC:945 brain-specific angiogenesis inhibitor 3 O60242 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota BAIAP2 HGNC:947 BAI1-associated protein 2 Q9UQB8 Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Perinuclear region (GO:0048471); Cytoplasm (GO:0005737) 10343108,10343108/10343108,12598619,10332026,10343108 cytoplasm 31 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa BAIAP2L1 HGNC:21649 BAI1-associated protein 2-like 1 Q9UHR4 Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. cytoplasm 100 0 cytoplasm cytoplasm NA NA Holozoa BAIAP2L2 HGNC:26203 BAI1-associated protein 2-like 2 Q6UXY1 Cell membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane. Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts. cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria BAIAP3 HGNC:948 BAI1-associated protein 3 O94812 endoplasmic reticulum membrane 21 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota BAK1 HGNC:949 BCL2-antagonist/killer 1 Q16611 Mitochondrion membrane; Single-pass membrane protein (Potential). Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Membrane fraction (GO:0005624) 11929871,12847083,15077116,12847083,12624178,12624108 cytoplasm 11 4 endoplasmic reticulum. mitochondrion multiple Tetrapoda Deuterostomia Cell.Organisms BAMBI HGNC:30251 BMP and activin membrane-bound inhibitor Q13145 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 14660579,12489181,11165491 secreted 87 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria BANF1 HGNC:17397 barrier to autointegration factor 1 O75531 Nucleus. Cytoplasm. Chromosome. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. May be included in HIV-1 virions via its interaction with viral GAG polyprotein. The phosphorylated form (by VRK1) shows a cytoplasmic localization. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10393804,15635413 nucleus 50 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa BANF2 HGNC:16172 barrier to autointegration factor 2 Q9H503 Nucleus. Cytoplasm. nucleus 22 0 cytoplasm. nucleus multiple Theria Theria Holozoa BANK1 HGNC:18233 B-cell scaffold protein with ankyrin repeats 1 Q8NDB2 Cytoplasm (GO:0005737) cytoplasm 54 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eumetazoa BANP HGNC:13450 BTG3 associated nuclear protein Q8N9N5 Nucleus. Nucleus (GO:0005634) 15701641,12494467 nucleus 100 0 nucleus nucleus Human Human Bilateria BAP1 HGNC:950 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) Q92560 Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Nucleus (GO:0005634) 9528852,17081983 nucleus 50 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta Eukaryota BARD1 HGNC:952 BRCA1 associated RING domain 1 Q99728 Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874) ,9342365,11925436,19176389,,11925436,,19176389, nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms BARHL1 HGNC:953 BarH-like homeobox 1 Q9BZE3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota BARHL2 HGNC:954 BarH-like homeobox 2 Q9NY43 Nucleus (Probable). Nucleus (GO:0005634) nucleus 90 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota BARX1 HGNC:955 BARX homeobox 1 Q9HBU1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota BARX2 HGNC:956 BARX homeobox 2 Q9UMQ3 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota BASP1 HGNC:957 brain abundant, membrane attached signal protein 1 P80723 Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14701728,9749536,14701728 cytoplasm 49 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Amniota BATF HGNC:958 basic leucine zipper transcription factor, ATF-like Q16520 Nucleus (By similarity). Cytoplasm (By similarity). Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells (By similarity). Nucleus (GO:0005634) 8570175 nucleus 51 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa BATF2 HGNC:25163 basic leucine zipper transcription factor, ATF-like 2 Q8N1L9 Nucleus (By similarity). nucleus 36 0 nucleus nucleus Eutheria Mammalia Bilateria BATF3 HGNC:28915 basic leucine zipper transcription factor, ATF-like 3 Q9NR55 Nucleus. Nucleus (GO:0005634) 10878360 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Bilateria BAX HGNC:959 BCL2-associated X protein Q07812 Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential). Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829); Membrane fraction (GO:0005624); Mitochondrial membrane (GO:0005740);Mitochondrion (GO:0005739) 11106734,11175336,15231068,10908576,12624108,12624108,10629050,16642033/15598749 plasma membrane 18 4 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Human Deuterostomia Cell.Organisms BAZ1A HGNC:960 bromodomain adjacent to zinc finger domain, 1A Q9NRL2 Nucleus. Note=May target the CHRAC complex to heterochromatin. Nucleus (GO:0005634) 10880450 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota BAZ1B HGNC:961 bromodomain adjacent to zinc finger domain, 1B Q9UIG0 Nucleus. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA. Nucleus (GO:0005634); Nucleolus (GO:0005730);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11980720,15561729,15635413,16514417/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia NA BAZ2A HGNC:962 bromodomain adjacent to zinc finger domain, 2A Q9UIF9 Nucleus, nucleolus (By similarity). Note=Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634) 11532953,17081983 nucleus 81 0 nucleus nucleus Eutheria Bilateria Eukaryota BAZ2B HGNC:963 bromodomain adjacent to zinc finger domain, 2B Q9UIF8 Nucleus (Potential). Nucleus (GO:0005634) 10662543,17081983 nucleus 32 0 nucleus nucleus Deuterostomia Bilateria Eukaryota BBC3 HGNC:17868 BCL2 binding component 3 Q96PG8 Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. Isoform 3 is not found in mitochondria. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11463392,11463391 mitochondrion 100 0 cytoplasm. mitochondrion multiple Theria Theria Mammalia BBIP1 HGNC:28093 BBSome interacting protein 1 A8MTZ0 Cell projection, cilium. Cytoplasm. Note=Localizes inside the primary cilium but not at centriolar satellites. cytoplasm 38 0 cytoplasm cytoplasm Mammalia Deuterostomia Euteleostomi BBOX1 HGNC:964 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 O75936 Cytoplasm. Peroxisome (GO:0005777); Cytoplasm (GO:0005737) 1735445,1735445 cytoplasm 100 0 cytoplasm. peroxisome multiple Bilateria Cell.Organisms Cell.Organisms BBS1 HGNC:966 Bardet-Biedl syndrome 1 Q8NFJ9 Cell projection, cilium membrane. Cytoplasm. Note=Localizes to nonmembranous centriolar satellites in the cytoplasm. Cytoplasm (GO:0005737) cytoplasm 4 0 cytoplasm cytoplasm Bilateria Cell.Organisms Eukaryota BBS10 HGNC:26291 Bardet-Biedl syndrome 10 Q8TAM1 Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. cytoplasm 11 3 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms BBS12 HGNC:26648 Bardet-Biedl syndrome 12 Q6ZW61 Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. cytoplasm 94 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota BBS2 HGNC:967 Bardet-Biedl syndrome 2 Q9BXC9 Cell projection, cilium membrane. Cytoplasm. Note=Localizes to nonmembranous centriolar satellites in the cytoplasm. Cytoplasm (GO:0005737) cytoplasm 63 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota BBS4 HGNC:969 Bardet-Biedl syndrome 4 Q96RK4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cell projection, cilium membrane. Cytoplasm. Note=Localizes to the pericentriolar region throughout the cell cycle. Centrosomal localization requires dynein. Localizes to nonmembranous centriolar satellites in the cytoplasm. Centrosome (GO:0005813) 1138127 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms BBS5 HGNC:970 Bardet-Biedl syndrome 5 Q8N3I7 Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Localizes to basal bodies (By similarity). Localizes to nonmembranous centriolar satellites. cytoplasm 12 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms BBS7 HGNC:18758 Bardet-Biedl syndrome 7 Q8IWZ6 Cell projection, cilium membrane. Cytoplasm. Note=Localizes to nonmembranous centriolar satellites in the cytoplasm. cytoplasm 45 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota BBS9 HGNC:30000 Bardet-Biedl syndrome 9 Q3SYG4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Note=Localizes to nonmembranous centriolar satellites in the cytoplasm. nucleus 36 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota BBX HGNC:14422 bobby sox homolog (Drosophila) Q8WY36 Nucleus (Probable). Nucleus (GO:0005634) nucleus 31 1 nucleus nucleus Euteleostomi Euteleostomi Eukaryota BCAM HGNC:6722 basal cell adhesion molecule (Lutheran blood group) P50895 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12244066 plasma membrane 8 1 plasma membrane plasma membrane Eutheria Euteleostomi Metazoa BCAN HGNC:23059 brevican Q96GW7 Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Membrane; Lipid-anchor, GPI- anchor. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11054543,11054543 secreted 29 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms BCAP29 HGNC:24131 B-cell receptor-associated protein 29 Q9UHQ4 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789) 12886015 endoplasmic reticulum membrane 78 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota BCAP31 HGNC:16695 B-cell receptor-associated protein 31 P51572 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 12668660,11042173,15598749 endoplasmic reticulum membrane 40 3 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. mitochondrion multiple Bilateria Bilateria NA BCAR1 HGNC:971 breast cancer anti-estrogen resistance 1 P56945 Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 9697683,11937718,10787408,8940134,11937718,17081983 cytoplasm 35 0 cytoplasm. endoplasmic reticulum. nucleus multiple Deuterostomia Bilateria Eukaryota BCAR3 HGNC:973 breast cancer anti-estrogen resistance 3 O75815 Nucleus (GO:0005634) 17081983 cytoplasm 30 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa BCAS1 HGNC:974 breast carcinoma amplified sequence 1 O75363 Cytoplasm. Cytoplasm (GO:0005737) 14567997 cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Amniota BCAS2 HGNC:975 breast carcinoma amplified sequence 2 O75934 Nucleus, nucleolus. Nucleus (GO:0005634) 12169396 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota BCAS3 HGNC:14347 breast carcinoma amplified sequence 3 Q9H6U6 Nucleus (Potential). nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota BCAS4 HGNC:14367 breast carcinoma amplified sequence 4 Q8TDM0 Cytoplasm (Potential). Cytoplasm (GO:0005737) 12378525 cytoplasm 52 0 cytoplasm cytoplasm Theria Theria Eukaryota BCAT1 HGNC:976 branched chain amino-acid transaminase 1, cytosolic P54687 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10471790,9165094,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms BCAT2 HGNC:977 branched chain amino-acid transaminase 2, mitochondrial O15382 Isoform A: Mitochondrion. Isoform B: Cytoplasm. Mitochondrion (GO:0005739) 12119021 mitochondrion 80 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms BCCIP HGNC:978 BRCA2 and CDKN1A interacting protein Q9P287 Nucleus. Note=Colocalizes with BRCA2 in discrete nuclear foci. Nucleus (GO:0005634);Nucleus (GO:0005634);Nucleus (GO:0005634) 1571364,12527204,11313963/14726710,10878006,15713648/ nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota BCDIN3D HGNC:27050 BCDIN3 domain containing Q7Z5W3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota BCHE HGNC:983 butyrylcholinesterase P06276 Secreted. Extracellular (GO:0005576) 9673783 secreted 100 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms BCKDHA HGNC:986 branched chain keto acid dehydrogenase E1, alpha polypeptide P12694 Mitochondrion matrix. Mitochondrion (GO:0005739) 1861457 mitochondrion 100 0 mitochondrion mitochondrion NA NA Cell.Organisms BCKDHB HGNC:987 branched chain keto acid dehydrogenase E1, beta polypeptide P21953 Mitochondrion matrix. Mitochondrion (GO:0005739) 1889817,12902323,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms BCKDK HGNC:16902 branched chain ketoacid dehydrogenase kinase O14874 Mitochondrion matrix. Mitochondrion (GO:0005739) 1377677 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Opisthokonta Eukaryota BCL10 HGNC:989 B-cell CLL/lymphoma 10 O95999 Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11021819,11021819 nucleus 80 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Metazoa BCL11A HGNC:13221 B-cell CLL/lymphoma 11A (zinc finger protein) Q9H165 Cytoplasm. Nucleus. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634) 10757802,11161790/10757802 nucleus 19 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota BCL11B HGNC:13222 B-cell CLL/lymphoma 11B (zinc finger protein) Q9C0K0 Nucleus (Potential). Nucleus (GO:0005634) 12930829,12692243,17245431 nucleus 20 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota BCL2 HGNC:990 B-cell CLL/lymphoma 2 P10415 Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829); Mitochondrial membrane (GO:0005740) 2250705,10567572,10567572,10567572,8551385,17418785,15231068,15210690,8551385,17418785,16642033,15210690 cytoplasm 25 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. mitochondrion membrane. nucleus. nucleus membrane multiple Chordata Chordata Cell.Organisms BCL2A1 HGNC:991 BCL2-related protein A1 Q16548 Cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11929871,8952545 cytoplasm 100 1 cytoplasm. mitochondrion multiple Amniota Amniota Cell.Organisms BCL2L1 HGNC:992 BCL2-like 1 Q07817 Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mitochondrial membranes and perinuclear envelope (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. Mitochondrial membrane (GO:0005740); Nucleus (GO:0005634); Cytosol (GO:0005829); Cytoplasm (GO:0005737) 11279541,15131699,11279541,11423909,15131699,17167422 cytoplasm 22 2 cytoplasm. mitochondrion membrane. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms BCL2L10 HGNC:993 BCL2-like 10 (apoptosis facilitator) Q9HD36 Mitochondrion. Nucleus membrane. Plasma membrane (GO:0005886) 11689480 plasma membrane 17 2 mitochondrion. plasma membrane multiple Theria Euteleostomi Euteleostomi BCL2L11 HGNC:994 BCL2-like 11 (apoptosis facilitator) O43521 Endomembrane system; Peripheral membrane protein (By similarity). Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Membrane fraction (GO:0005624) 11301022,11734221,9430630,11734221,8929531,8918887,11734221,9430630 nucleus 38 0 cytoplasm. mitochondrion. nucleus multiple Mammalia Mammalia Olfactores BCL2L12 HGNC:13787 BCL2-like 12 (proline rich) Q9HB09 Nucleus (GO:0005634) 17081983 nucleus 56 0 nucleus nucleus Eutheria Eutheria Euteleostomi BCL2L13 HGNC:17164 BCL2-like 13 (apoptosis facilitator) Q9BXK5 Isoform 2: Mitochondrion membrane; Single- pass membrane protein (Potential). Nucleus (Probable). Isoform 1: Nucleus (Probable). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11262395,15598749,17081983 plasma membrane 60 1 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Bilateria BCL2L14 HGNC:16657 BCL2-like 14 (apoptosis facilitator) Q9BZR8 Cytoplasm. Isoform 1: Cytoplasm, cytosol. Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles. Cytosol (GO:0005829);Cytosol (GO:0005829); Mitochondrion (GO:0005739) 11054413/11054413,11054413 nucleus 57 0 cytoplasm. mitochondrion multiple Euarchontoglires Tetrapoda Euteleostomi BCL2L15 HGNC:33624 BCL2-like 15 Q5TBC7 Cytoplasm (GO:0005737) 15961081 secreted 12 0 cytoplasm cytoplasm Theria Amniota Euteleostomi BCL2L2 HGNC:995 BCL2-like 2 Q92843 Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 11423909,11423909,11423909 cytoplasm 14 2 cytoplasm. mitochondrion. nucleus multiple Mammalia Tetrapoda Cell.Organisms BCL3 HGNC:998 B-cell CLL/lymphoma 3 P20749 Nucleus. Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11707390,14678988,8497270 golgi apparatus 22 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Cell.Organisms BCL6 HGNC:1001 B-cell CLL/lymphoma 6 P41182 Nucleus (By similarity). Nucleus (GO:0005634) 9927193,7795255 nucleus 94 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota BCL6B HGNC:1002 B-cell CLL/lymphoma 6, member B Q8N143 Nucleus (By similarity). Nucleus (GO:0005634) 9632807 nucleus 89 0 nucleus nucleus Theria Chordata Eukaryota BCL7A HGNC:1004 B-cell CLL/lymphoma 7A Q4VC05 Cytoplasm (GO:0005737) 9931421 nucleus 80 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa BCL7B HGNC:1005 B-cell CLL/lymphoma 7B Q9BQE9 Nucleus (GO:0005634) 17081983 nucleus 85 0 nucleus nucleus Chordata Chordata NA BCL7C HGNC:1006 B-cell CLL/lymphoma 7C Q8WUZ0 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9931421,17081983 nucleus 81 0 cytoplasm. nucleus multiple Mammalia Tetrapoda Metazoa BCL9 HGNC:1008 B-cell CLL/lymphoma 9 O00512 Nucleus (By similarity). Nucleus (GO:0005634) 9490669 nucleus 94 0 nucleus nucleus Euteleostomi Euteleostomi NA BCL9L HGNC:23688 B-cell CLL/lymphoma 9-like Q86UU0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12964048,15574752,17081983,15574752,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata BCLAF1 HGNC:16863 BCL2-associated transcription factor 1 Q9NYF8 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10330179,15009215,17081983,10330179,17081983 nucleus 23 0 cytoplasm. nucleus multiple Amniota Amniota Craniata BCMO1 HGNC:13815 beta-carotene 15,15'-monooxygenase 1 Q9HAY6 mitochondrion 29 0 mitochondrion mitochondrion Deuterostomia Eukaryota Cell.Organisms BCO2 HGNC:18503 beta-carotene oxygenase 2 Q9BYV7 Mitochondrion. Cytoplasm (GO:0005737) mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Eukaryota Cell.Organisms BCOR HGNC:20893 BCL6 corepressor Q6W2J9 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983/10898795/10898795,10898795 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms BCORL1 HGNC:25657 BCL6 corepressor-like 1 Q5H9F3 Nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms BCR HGNC:1014 breakpoint cluster region P11274 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7724587,11069024 nucleus 18 1 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota BCS1L HGNC:1020 BC1 (ubiquinol-cytochrome c reductase) synthesis-like Q9Y276 Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion (GO:0005739) 9878253,8599931,15598749 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms BDH1 HGNC:1027 3-hydroxybutyrate dehydrogenase, type 1 Q02338 Mitochondrion matrix. Mitochondrial membrane (GO:0005740) 11009606 mitochondrion 100 0 mitochondrion. mitochondrion membrane multiple Deuterostomia Eukaryota Cell.Organisms BDH2 HGNC:32389 3-hydroxybutyrate dehydrogenase, type 2 Q9BUT1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms BDKRB1 HGNC:1029 bradykinin receptor B1 P46663 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8995263 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa BDKRB2 HGNC:1030 bradykinin receptor B2 P30411 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1314587 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa BDNF HGNC:1033 brain-derived neurotrophic factor P23560 Secreted. Extracellular (GO:0005576); Secretory granule (GO:0030141); Golgi apparatus (GO:0005794) 12912764,9580557,9580557 secreted 100 0 golgi apparatus. secreted multiple Euteleostomi Euteleostomi Bilateria BDP1 HGNC:13652 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB A6H8Y1 Nucleus. Nucleus (GO:0005634) 11161782 nucleus 100 1 nucleus nucleus Amniota Euteleostomi NA BEAN1 HGNC:24160 brain expressed, associated with NEDD4, 1 Q3B7T3 Membrane; Single-pass membrane protein (Potential). nucleus 31 1 nucleus nucleus Eutheria Euteleostomi Opisthokonta BECN1 HGNC:1034 beclin 1, autophagy related Q14457 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11309306,11309306,11306555 nucleus 18 0 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Eukaryota BEGAIN HGNC:24163 brain-enriched guanylate kinase-associated Q9BUH8 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12097487,17081983,17081983 cytoplasm 12 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eumetazoa BEND2 HGNC:28509 BEN domain containing 2 Q8NDZ0 secreted 56 0 secreted secreted Amniota Euteleostomi Opisthokonta BEND3 HGNC:23040 BEN domain containing 3 Q5T5X7 Nucleus (GO:0005634) 17000644 nucleus 87 0 nucleus nucleus Tetrapoda Euteleostomi NA BEND4 HGNC:23815 BEN domain containing 4 Q6ZU67 plasma membrane 15 0 n/a n/a Tetrapoda Euteleostomi Bilateria BEND5 HGNC:25668 BEN domain containing 5 Q7L4P6 nucleus 83 0 nucleus nucleus Tetrapoda Euteleostomi Bilateria BEND6 HGNC:20871 BEN domain containing 6 Q5SZJ8 nucleus 78 0 nucleus nucleus Theria Amniota Bilateria BEND7 HGNC:23514 BEN domain containing 7 Q8N7W2 nucleus 87 0 nucleus nucleus Euteleostomi Euteleostomi Craniata BEST1 HGNC:12703 bestrophin 1 O76090 Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Plasma membrane (GO:0005886) 11050159,12058047 plasma membrane 55 6 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa BEST2 HGNC:17107 bestrophin 2 Q8NFU1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 12032738 plasma membrane 100 6 plasma membrane plasma membrane Theria Bilateria Holozoa BEST3 HGNC:17105 bestrophin 3 Q8N1M1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 6 plasma membrane plasma membrane Human Bilateria Holozoa BEST4 HGNC:17106 bestrophin 4 Q8NFU0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 5 plasma membrane plasma membrane Tetrapoda Tetrapoda Holozoa BET1 HGNC:14562 Bet1 golgi vesicular membrane trafficking protein O15155 Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9382863,8621431,17081983,17081983 golgi apparatus membrane 25 1 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota BET1L HGNC:19348 Bet1 golgi vesicular membrane trafficking protein-like Q9NYM9 Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus (GO:0005794); Endosome (GO:0005768) 9242691,15215310 golgi apparatus membrane 85 1 endosome. golgi apparatus multiple Tetrapoda Eukaryota Eukaryota BEX1 HGNC:1036 brain expressed, X-linked 1 Q9HBH7 Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16498402,16498402 cytoplasm 30 0 cytoplasm. nucleus multiple Eutheria Eutheria Eutheria BEX2 HGNC:30933 brain expressed X-linked 2 Q9BXY8 Cytoplasm (By similarity). Nucleus. cytoplasm 32 0 nucleus nucleus Eutheria Eutheria Eutheria BEX4 HGNC:25475 brain expressed, X-linked 4 Q9NWD9 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 47 0 cytoplasm cytoplasm Eutheria Eutheria Eutheria BEX5 HGNC:27990 brain expressed, X-linked 5 Q5H9J7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Eutheria NA BFAR HGNC:17613 bifunctional apoptosis regulator Q9NZS9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 10716992 endoplasmic reticulum membrane 100 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Eukaryota Eukaryota BFSP1 HGNC:1040 beaded filament structural protein 1, filensin Q12934 Membrane. Cytoplasm. Cytoplasm, cytoskeleton. Note=Membrane- and cytoskeleton-associated. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9628810,7679620,7615661 cytoplasm 9 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Olfactores BFSP2 HGNC:1041 beaded filament structural protein 2, phakinin Q13515 Membrane. Cytoplasm. Cytoplasm, cytoskeleton. Note=Membrane- and cytoskeleton-associated. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8636093,7504675,10753642 cytoplasm 13 0 cytoplasm cytoplasm Amniota Euteleostomi Bilateria BGLAP HGNC:1043 bone gamma-carboxyglutamate (gla) protein P02818 Secreted. Extracellular (GO:0005576) 7768973 secreted 100 0 secreted secreted NA NA Euteleostomi BGN HGNC:1044 biglycan P21810 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11709279 secreted 94 0 secreted secreted Euteleostomi Euteleostomi NA BHLHA15 HGNC:22265 basic helix-loop-helix family, member a15 Q7RTS1 Nucleus (Probable). Nucleus (GO:0005634) 11696558,9073453 cytoplasm 53 0 nucleus nucleus Amniota Bilateria Holozoa BHLHA9 HGNC:35126 basic helix-loop-helix family, member a9 Q7RTU4 Nucleus (By similarity). nucleus 35 0 nucleus nucleus Amniota Amniota Bilateria BHLHB9 HGNC:29353 basic helix-loop-helix domain containing, class B, 9 Q6PI77 Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15034937,15034937 cytoplasm 21 0 cytoplasm. nucleus multiple Euarchontoglires Euarchontoglires Euteleostomi BHLHE22 HGNC:11963 basic helix-loop-helix family, member e22 Q8NFJ8 Nucleus (Probable). nucleus 40 0 nucleus nucleus Theria Bilateria Metazoa BHLHE23 HGNC:16093 basic helix-loop-helix family, member e23 Q8NDY6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus Bilateria Bilateria Metazoa BHLHE40 HGNC:1046 basic helix-loop-helix family, member e40 O14503 Nucleus. Nucleus (GO:0005634) 12624110,12119049,12754744,12297495 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa BHLHE41 HGNC:16617 basic helix-loop-helix family, member e41 Q9C0J9 Nucleus (By similarity). nucleus 35 3 nucleus nucleus Theria Euteleostomi Metazoa BHMT HGNC:1047 betaine--homocysteine S-methyltransferase Q93088 Cytoplasm. Cytoplasm (GO:0005737) 11516176 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms BHMT2 HGNC:1048 betaine--homocysteine S-methyltransferase 2 Q9H2M3 cytoplasm 73 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms BICC1 HGNC:19351 BicC family RNA binding protein 1 Q9H694 cytoplasm 18 0 cytoplasm cytoplasm Chordata Bilateria Opisthokonta BICD1 HGNC:1049 bicaudal D homolog 1 (Drosophila) Q96G01 Golgi apparatus. Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Centrosome (GO:0005813); Plasma membrane (GO:0005886) 12892780,12447383,17139249,17139249 golgi apparatus 100 0 golgi apparatus golgi apparatus Bilateria Bilateria Eukaryota BICD2 HGNC:17208 bicaudal D homolog 2 (Drosophila) Q8TD16 Golgi apparatus. Cytoplasm, cytoskeleton. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Its localization is dependent on microtubule morphology. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Centrosome (GO:0005813); Microtubule (GO:0005874) 17081983,17081983/11483508,11483508,17139249,11483508 golgi apparatus 59 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota BID HGNC:1050 BH3 interacting domain death agonist P55957 Cytoplasm (By similarity). Mitochondrion membrane (By similarity). BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Cytosol (GO:0005829); Membrane fraction (GO:0005624); Lysosome (GO:0005764) 9727492,15598749,9727492,12624108,12624108,11099414 nucleus 31 0 cytoplasm. lysosome. mitochondrion multiple Tetrapoda Tetrapoda Tetrapoda BIK HGNC:1051 BCL2-interacting killer (apoptosis-inducing) Q13323 Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein (By similarity). Note=Around the nuclear envelope, and in cytoplasmic membranes. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12853473,11884414,8816500,11884414,8816500 secreted 84 1 cytoplasm. endomembrane system. endoplasmic reticulum. nucleus multiple Euarchontoglires Eutheria Boreoeutheria BIN1 HGNC:1052 bridging integrator 1 O00499 Isoform BIN1: Nucleus. Isoform IIA: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 9182667,12532338,12532338,10391921/17081983,17081983/17081983 cytoplasm 9 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota BIN2 HGNC:1053 bridging integrator 2 Q9UBW5 Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. Cytoplasm (GO:0005737) 10903846 plasma membrane 22 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota BIN3 HGNC:1054 bridging integrator 3 Q9NQY0 Cytoplasm, cytoskeleton. Mitochondrion (GO:0005739); Golgi apparatus (GO:0005794) 11274158,11274158 cytoplasm 100 0 cytoplasm. golgi apparatus. mitochondrion multiple Chordata Chordata Eukaryota BIRC2 HGNC:590 baculoviral IAP repeat containing 2 Q13490 Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells. Cytoplasm (GO:0005737); Cytosol (GO:0005829); Plasma membrane (GO:0005886) 9384571,,19898473,,,19898473, cytoplasm 32 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota BIRC3 HGNC:591 baculoviral IAP repeat containing 3 Q13489 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829) ,,19898473,,,19898473, cytoplasm 32 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota BIRC5 HGNC:593 baculoviral IAP repeat containing 5 O15392 Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export. Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Centrosome (GO:0005813); Chromosome (GO:0005694); Microtubule (GO:0005874);Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11134084,11861764,11861764,11861764,16291752,17099693,15561729/16291752/16291752,16291752 secreted 10 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Opisthokonta BIRC6 HGNC:13516 baculoviral IAP repeat containing 6 Q9NR09 Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10544019,17081983,10544019 nucleus 18 8 cytoplasm. endosome. nucleus multiple Bilateria Eukaryota Eukaryota BIRC7 HGNC:13702 baculoviral IAP repeat containing 7 Q96CA5 Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11024045,11024045,11084335 nucleus 39 0 cytoplasm. golgi apparatus. nucleus multiple Theria Bilateria Eukaryota BIRC8 HGNC:14878 baculoviral IAP repeat containing 8 Q96P09 Cytoplasm (Probable). cytoplasm 17 0 cytoplasm cytoplasm NA NA Eukaryota BIVM HGNC:16034 basic, immunoglobulin-like variable motif containing Q86UB2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12036287,12036287 nucleus 74 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota BLACE HGNC:20484 B-cell acute lymphoblastic leukemia expressed A4D250 secreted 25 0 secreted secreted NA NA Homo BLCAP HGNC:1055 bladder cancer associated protein P62952 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 13 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Bilateria Opisthokonta BLID HGNC:33495 BH3-like motif containing, cell death inducer Q8IZY5 Cytoplasm. Mitochondrion. Note=Lower abundance in mitochondrion than in cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15069058,15069058 secreted 25 0 cytoplasm. mitochondrion multiple NA NA Boreoeutheria BLK HGNC:1057 B lymphoid tyrosine kinase P51451 Cell membrane; Lipid-anchor (By similarity). Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). Mitochondrion (GO:0005739) 9525867 cytoplasm 30 0 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms BLM HGNC:1058 Bloom syndrome, RecQ helicase-like P54132 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11691925,14688284,15775963,15229185,15143166,11399766,15364958,15257300,15561729,10779560,15635413,11790298,15364958 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms BLMH HGNC:1059 bleomycin hydrolase Q13867 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Ribosome (GO:0005840) 8639621,8639621,10353821,10353821 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms BLNK HGNC:14211 B-cell linker Q8WV28 Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11071869,11449366 cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Deuterostomia NA BLOC1S1 HGNC:4200 biogenesis of lysosomal organelles complex-1, subunit 1 P78537 Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. cytoplasm 33 0 cytoplasm. mitochondrion multiple Eutheria Eukaryota Eukaryota BLOC1S2 HGNC:20984 biogenesis of lysosomal organelles complex-1, subunit 2 Q6QNY1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosomes in a microtubule-dependent manner. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota BLOC1S3 HGNC:20914 biogenesis of lysosomal organelles complex-1, subunit 3 Q6QNY0 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 15102850,17081983 cytoplasm 87 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Craniata BLOC1S4 HGNC:24206 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino Q9NUP1 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12576321 cytoplasm 78 0 cytoplasm cytoplasm Deuterostomia Eukaryota Holozoa BLOC1S5 HGNC:18561 biogenesis of lysosomal organelles complex-1, subunit 5, muted Q8TDH9 Cytoplasmic vesicle (GO:0016023) 11912185 nucleus 38 0 nucleus nucleus Deuterostomia Bilateria Holozoa BLOC1S6 HGNC:8549 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Q9UL45 Cytoplasm. Endomembrane system; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein. Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 8986625,8608138 nucleus 60 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eumetazoa BLVRA HGNC:1062 biliverdin reductase A P53004 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8631357,14988408 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Eumetazoa BLVRB HGNC:1063 biliverdin reductase B (flavin reductase (NADPH)) P30043 Cytoplasm. Cytoplasm (GO:0005737) 7929092 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms BLZF1 HGNC:1065 basic leucine zipper nuclear factor 1 Q9H2G9 Golgi apparatus lumen. Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 11056056,10602419,11739401 cytoplasm 22 0 cytoplasm. golgi apparatus. nucleus multiple Chordata Bilateria Holozoa BMF HGNC:24132 Bcl2 modifying factor Q96LC9 Actin filament (GO:0005884); Mitochondrion (GO:0005739) 11546872,11546872 secreted 43 0 mitochondrion mitochondrion Tetrapoda Euteleostomi Tetrapoda BMI1 HGNC:1066 BMI1 polycomb ring finger oncogene P35226 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12482919,10574711,17081983,17081983 nucleus 78 1 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota BMP1 HGNC:1067 bone morphogenetic protein 1 P13497 Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Note=Co- localizes with POSTN in the Golgi (By similarity). Cytoplasm (GO:0005737); Extracellular (GO:0005576);Nucleus (GO:0005634) 12637537,10806203,8643539/17081983 secreted 66 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Bilateria Bilateria Cell.Organisms BMP10 HGNC:20869 bone morphogenetic protein 10 O95393 Secreted (By similarity). Extracellular (GO:0005576) secreted 28 0 secreted secreted Euteleostomi Euteleostomi Metazoa BMP15 HGNC:1068 bone morphogenetic protein 15 O95972 Secreted. Extracellular (GO:0005576) 11741284,10998422 secreted 100 0 secreted secreted Euteleostomi Euteleostomi NA BMP2 HGNC:1069 bone morphogenetic protein 2 P12643 Secreted. Extracellular (GO:0005576) 11811554 secreted 100 0 secreted secreted Bilateria Bilateria Metazoa BMP2K HGNC:18041 BMP2 inducible kinase Q9NSY1 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms BMP3 HGNC:1070 bone morphogenetic protein 3 P12645 Secreted. Extracellular (GO:0005576) 9434787 secreted 100 0 secreted secreted Euteleostomi Deuterostomia Metazoa BMP4 HGNC:1071 bone morphogenetic protein 4 P12644 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11156467 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa BMP5 HGNC:1072 bone morphogenetic protein 5 P22003 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11865031,11564221 secreted 100 0 cytoplasm. secreted multiple Bilateria Bilateria Metazoa BMP6 HGNC:1073 bone morphogenetic protein 6 P22004 Secreted (By similarity). Cytoplasm (GO:0005737) 9331107 secreted 60 0 cytoplasm cytoplasm Euarchontoglires Chordata Metazoa BMP7 HGNC:1074 bone morphogenetic protein 7 P18075 Secreted. Extracellular (GO:0005576) 8297380 secreted 100 0 secreted secreted Bilateria Bilateria Metazoa BMP8A HGNC:21650 bone morphogenetic protein 8a Q7Z5Y6 Secreted (Probable). Extracellular (GO:0005576) secreted 41 0 secreted secreted Euteleostomi Euteleostomi Metazoa BMP8B HGNC:1075 bone morphogenetic protein 8b P34820 Secreted (By similarity). Extracellular (GO:0005576) 1460021 secreted 42 0 secreted secreted Euteleostomi Euteleostomi Metazoa BMPER HGNC:24154 BMP binding endothelial regulator Q8N8U9 Secreted. Extracellular (GO:0005576) 14766204,12897139 secreted 100 0 secreted secreted Deuterostomia Bilateria Cell.Organisms BMPR1A HGNC:1076 bone morphogenetic protein receptor, type IA P36894 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8707881,17081983 plasma membrane 14 1 cytoplasm. plasma membrane multiple Bilateria Bilateria Cell.Organisms BMPR1B HGNC:1077 bone morphogenetic protein receptor, type IB O00238 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8707881 plasma membrane 13 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms BMPR2 HGNC:1078 bone morphogenetic protein receptor, type II (serine/threonine kinase) Q13873 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 7791754/7644468,7890683 plasma membrane 18 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms BMS1 HGNC:23505 BMS1 ribosome biogenesis factor Q14692 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730); Ribosome (GO:0005840); Nucleus (GO:0005634) 15635413,11790298,15561729,17081983 nucleus 10 0 nucleus nucleus Eukaryota Eukaryota Eukaryota BMX HGNC:1079 BMX non-receptor tyrosine kinase P51813 Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10962576,10196179,10962576,10196179 cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms BNC1 HGNC:1081 basonuclin 1 Q01954 Nucleus (By similarity). Cytoplasm (By similarity). Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813); Mitochondrion (GO:0005739) 8034748,1332044,10839715,9687312,10839715,9151672,9151672 nucleus 37 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Bilateria Bilateria BNC2 HGNC:30988 basonuclin 2 Q6ZN30 Nucleus. Nucleus (GO:0005634) 15081112 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Bilateria BNIP1 HGNC:1082 BCL2/adenovirus E1B 19kDa interacting protein 1 Q12981 Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1332047,7954800 nucleus 14 1 cytoplasm. endoplasmic reticulum membrane. mitochondrion. nucleus multiple Bilateria Eukaryota Eukaryota BNIP2 HGNC:1083 BCL2/adenovirus E1B 19kDa interacting protein 2 Q12982 Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures. cytoplasm 100 3 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota BNIP3 HGNC:1084 BCL2/adenovirus E1B 19kDa interacting protein 3 Q12983 Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 9396766,9973195,12690108 nucleus 16 1 mitochondrion. mitochondrion membrane. plasma membrane multiple Tetrapoda Deuterostomia Bilateria BNIP3L HGNC:1085 BCL2/adenovirus E1B 19kDa interacting protein 3-like O60238 Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein (Potential). Note=Colocalizes with SPATA18 at the mitochondrion outer membrane. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9867803,9973195,17081983,17081983 nucleus 17 1 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Bilateria BNIPL HGNC:16976 BCL2/adenovirus E1B 19kD interacting protein like Q7Z465 Cytoplasm (GO:0005737) 11741952,12681488 cytoplasm 38 3 cytoplasm cytoplasm Theria Euteleostomi Eukaryota BOC HGNC:17173 BOC cell adhesion associated, oncogene regulated Q9BWV1 Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell contact. Integral to membrane (GO:0016021) 12720294,11782431 plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms BOD1 HGNC:25114 biorientation of chromosomes in cell division 1 Q96IK1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase. nucleus 55 0 cytoplasm. nucleus multiple Chordata Bilateria Metazoa BOD1L1 HGNC:31792 biorientation of chromosomes in cell division 1-like 1 Q8NFC6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 golgi apparatus membrane 22 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eumetazoa BOD1L2 HGNC:28505 biorientation of chromosomes in cell division 1-like 2 Q8IYS8 nucleus 63 0 nucleus nucleus NA NA Eumetazoa BOK HGNC:1087 BCL2-related ovarian killer Q9UMX3 Mitochondrion (GO:0005739) 15102863 plasma membrane 52 2 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms BOLA1 HGNC:24263 bolA family member 1 Q9Y3E2 Secreted. Note=Could be secreted via a non- classical export pathway. secreted 100 0 secreted secreted Eutheria Cell.Organisms NA BOLA2 HGNC:29488 bolA family member 2 Q9H3K6 secreted 31 0 secreted secreted Theria Eukaryota Cell.Organisms BOLA2B HGNC:32479 bolA family member 2B Q9H3K6 secreted 31 0 secreted secreted Theria Eukaryota Cell.Organisms BOLA3 HGNC:24415 bolA family member 3 Q53S33 Secreted. Note=Could be secreted via a non- classical export pathway. secreted 100 0 secreted secreted Human Eukaryota Eukaryota BOLL HGNC:14273 boule-like RNA-binding protein Q8N9W6 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11390979,15070965,9882490 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Bilateria Cell.Organisms BOP1 HGNC:15519 block of proliferation 1 Q14137 Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleolus (GO:0005730); Nucleus (GO:0005634) 12429849,12048210,11522832,11390653,15635413,11790298,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA BORA HGNC:24724 bora, aurora kinase A activator Q6PGQ7 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16890155,16890155 nucleus 84 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa BPGM HGNC:1093 2,3-bisphosphoglycerate mutase P07738 cytoplasm 36 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms BPHL HGNC:1094 biphenyl hydrolase-like (serine hydrolase) Q86WA6 mitochondrion 82 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms BPI HGNC:1095 bactericidal/permeability-increasing protein P17213 Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. Secretory granule (GO:0030141); Plasma membrane (GO:0005886) 8330906,11891303 secreted 32 0 secreted secreted Catarrhini Euarchontoglires Eukaryota BPIFA1 HGNC:15749 BPI fold containing family A, member 1 Q9NP55 Secreted (By similarity). Note=Found in the nasal mucus (By similarity). Apical side of airway epithelial cells. Detected in nasal mucus (By similarity). Extracellular (GO:0005576) 11821380,12409287,15313462 secreted 66 0 secreted secreted Theria Theria Mammalia BPIFA2 HGNC:16203 BPI fold containing family A, member 2 Q96DR5 Secreted (By similarity). secreted 20 0 secreted secreted Eutheria Eutheria Mammalia BPIFA3 HGNC:16204 BPI fold containing family A, member 3 Q9BQP9 Secreted (Potential). secreted 15 0 secreted secreted Eutheria Eutheria Mammalia BPIFB1 HGNC:16108 BPI fold containing family B, member 1 Q8TDL5 Secreted (By similarity). secreted 50 0 secreted secreted Mammalia Mammalia Euteleostomi BPIFB2 HGNC:16177 BPI fold containing family B, member 2 Q8N4F0 Secreted (By similarity). Cytoplasm (GO:0005737) 12837268 secreted 7 0 cytoplasm cytoplasm Theria Theria Holozoa BPIFB3 HGNC:16178 BPI fold containing family B, member 3 P59826 Secreted (By similarity). Cytoplasm. Note=According to PubMed:12837268, it is cytoplasmic. secreted 5 0 cytoplasm cytoplasm Theria Theria Euteleostomi BPIFB4 HGNC:16179 BPI fold containing family B, member 4 P59827 Secreted (By similarity). Cytoplasm. Cytoplasm (GO:0005737) 12837268 secreted 5 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota BPIFB6 HGNC:16504 BPI fold containing family B, member 6 Q8NFQ5 Secreted (By similarity). secreted 5 0 secreted secreted Amniota Amniota Euteleostomi BPIFC HGNC:16503 BPI fold containing family C Q8NFQ6 Secreted (By similarity). secreted 7 0 secreted secreted Amniota Amniota Eukaryota BPNT1 HGNC:1096 3'(2'), 5'-bisphosphate nucleotidase 1 O95861 golgi apparatus membrane 17 0 golgi apparatus membrane golgi apparatus membrane Bilateria Eukaryota Cell.Organisms BPTF HGNC:3581 bromodomain PHD finger transcription factor Q12830 Cytoplasm. Nucleus. Note=In brains of Alzheimer disease patients, present in a subset of amyloid- containing plaques. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 7621746,10403843,8975731,7621746,8975731,15379550,15379550 nucleus 40 1 cytoplasm. nucleus multiple Bilateria Bilateria NA BPY2 HGNC:13508 basic charge, Y-linked, 2 O14599 secreted 24 0 secreted secreted Homininae Homininae Primates BPY2B HGNC:25449 basic charge, Y-linked, 2B O14599 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12724276,12724276 secreted 24 0 cytoplasm. nucleus multiple Homininae Homininae Primates BPY2C HGNC:18225 basic charge, Y-linked, 2C O14599 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12724276,12724276 secreted 24 0 cytoplasm. nucleus multiple Homininae Homininae Primates BRAF HGNC:1097 v-raf murine sarcoma viral oncogene homolog B P15056 Nucleus (By similarity). Cytoplasm. Cell membrane (By similarity). Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12068308,16858395,11325826,16858395 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms BRAP HGNC:1099 BRCA1 associated protein Q7Z569 Cytoplasm. Cytoplasm (GO:0005737) 9497340 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota BRAT1 HGNC:21701 BRCA1-associated ATM activator 1 Q6PJG6 Nucleus. Note=Present at double strand breaks (DSBs) following ionizing radiation treatment. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa BRCA1 HGNC:1100 breast cancer 1, early onset P38398 Nucleus. Chromosome (By similarity). Isoform 3: Cytoplasm. Isoform 5: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813); Perinuclear region (GO:0048471); Mitochondrion (GO:0005739);Cytoplasm (GO:0005737) 9010228,9010228/,8972225,9207057,8910495,8764100,9267023,9010228,9244350,15591126,10417779,7481765,11278964,9582019,12955082,15065664,19176389,12419249,,10991937,9010228,9244350,10417779,7481765,9789027,12214252,9244350,15591126/8972225 cytoplasm 29 1 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Chordata Eukaryota BRCA2 HGNC:1101 breast cancer 2, early onset P51587 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10570174,9560268,15065660,10570174,16188874 nucleus 81 0 cytoplasm. nucleus. secreted multiple Tetrapoda Eukaryota Eukaryota BRCC3 HGNC:24185 BRCA1/BRCA2-containing complex, subunit 3 P46736 Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota NA BRD1 HGNC:1102 bromodomain containing 1 O95696 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10602503,17081983,10602503,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota BRD2 HGNC:1103 bromodomain containing 2 P25440 Nucleus (Probable). Note=Detected on chromatin and nucleosomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9693039,10934046,12145330,17081983,10934046,12145330 nucleus 96 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta NA BRD3 HGNC:1104 bromodomain containing 3 Q15059 Nucleus (Probable). Note=Detected on chromatin (By similarity). Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 nucleus 93 0 nucleus nucleus Euteleostomi Opisthokonta Eukaryota BRD4 HGNC:13575 bromodomain containing 4 O60885 Nucleus. Chromosome. Note=Associates with acetylated chromatin. Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,10938129,15109495,16109376,/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Mammalia Bilateria Eukaryota BRD7 HGNC:14310 bromodomain containing 7 Q9NPI1 Isoform 2: Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10526152,11025449,12489984,10526152 nucleus 100 1 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota BRD8 HGNC:19874 bromodomain containing 8 Q9H0E9 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/9368056 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota BRD9 HGNC:25818 bromodomain containing 9 Q9H8M2 nucleus 26 1 nucleus nucleus Euteleostomi Euteleostomi Eukaryota BRDT HGNC:1105 bromodomain, testis-specific Q58F21 Nucleus. Note=Detected on chromatin. Nucleus (GO:0005634) 12861021,10704737 nucleus 100 0 nucleus nucleus Mammalia Opisthokonta Eukaryota BRE HGNC:1106 brain and reproductive organ-expressed (TNFRSF1A modulator) Q9NXR7 Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Cytosol (GO:0005829); Nucleus (GO:0005634) 15465831,15582573,15465831,15582573 nucleus 55 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota BRF1 HGNC:11551 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit Q92994 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 24 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms BRF2 HGNC:17298 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit Q9HAW0 Nucleus. Nucleus (GO:0005634) 11040218 nucleus 100 0 nucleus nucleus Amniota Deuterostomia Cell.Organisms BRI3 HGNC:1109 brain protein I3 O95415 Membrane; Multi-pass membrane protein (Potential). Lysosome (GO:0005764) 14592447 secreted 81 1 lysosome lysosome Theria Bilateria Eumetazoa BRI3BP HGNC:14251 BRI3 binding protein Q8WY22 Mitochondrion outer membrane; Multi-pass membrane protein (Probable). plasma membrane 31 5 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Craniata BRICD5 HGNC:28309 BRICHOS domain containing 5 Q6PL45 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 58 2 n/a n/a Theria Euteleostomi Euteleostomi BRINP1 HGNC:2687 bone morphogenetic protein/retinoic acid inducible neural-specific 1 O60477 Cytoplasm. Cytoplasm (GO:0005737) 11420708 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Chordata BRINP2 HGNC:13746 bone morphogenetic protein/retinoic acid inducible neural-specific 2 Q9C0B6 Secreted (Potential). cytoplasm 44 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Chordata BRINP3 HGNC:22393 bone morphogenetic protein/retinoic acid inducible neural-specific 3 Q76B58 Secreted (Potential). cytoplasm 42 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Chordata BRIP1 HGNC:20473 BRCA1 interacting protein C-terminal helicase 1 Q9BX63 Nucleus. Nucleus (GO:0005634) 11301010 nucleus 100 0 nucleus nucleus Chordata Cell.Organisms Cell.Organisms BRIX1 HGNC:24170 BRX1, biogenesis of ribosomes, homolog (S. cerevisiae) Q8TDN6 Nucleus, nucleolus. Nucleolus (GO:0005730); Extracellular (GO:0005576); Ribosome (GO:0005840); Nucleus (GO:0005634) 11843177,11790298,16188874,15561729,17081983 nucleus 100 0 nucleus. secreted multiple Eukaryota Eukaryota Eukaryota BRK1 HGNC:23057 BRICK1, SCAR/WAVE actin-nucleating complex subunit Q8WUW1 Cytoplasm, cytoskeleton (By similarity). cytoplasm 27 0 cytoplasm cytoplasm NA NA Eukaryota BRMS1 HGNC:17262 breast cancer metastasis suppressor 1 Q9HCU9 Nucleus. Cytoplasm. Note=Predominantly nuclear. nucleus 5 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eukaryota BRMS1L HGNC:20512 breast cancer metastasis-suppressor 1-like Q5PSV4 Nucleus (Probable). Nucleus (GO:0005634) 15451426 nucleus 15 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota BROX HGNC:26512 BRO1 domain and CAAX motif containing Q5VW32 Membrane; Lipid-anchor (Potential). cytoplasm 58 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota BRPF1 HGNC:14255 bromodomain and PHD finger containing, 1 P55201 Nucleus. Cytoplasm. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6. Nucleus (GO:0005634) 7906940 nucleus 46 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota BRPF3 HGNC:14256 bromodomain and PHD finger containing, 3 Q9ULD4 Nucleus (GO:0005634) none,17081983 nucleus 50 1 nucleus nucleus Opisthokonta Eukaryota Eukaryota BRS3 HGNC:1113 bombesin-like receptor 3 P32247 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9593699 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Bilateria Metazoa BRSK1 HGNC:18994 BR serine/threonine kinase 1 Q8TDC3 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cell junction, synapse (By similarity). Note=Localizes to synaptic vesicles in neurons (By similarity). Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS- induced DNA damage. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15150265,15150265 secreted 45 1 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms BRSK2 HGNC:11405 BR serine/threonine kinase 2 Q8IWQ3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15150265,15150265 secreted 48 1 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms BRWD1 HGNC:12760 bromodomain and WD repeat domain containing 1 Q9NSI6 Cytoplasm. Nucleus (By similarity). Nucleus (GO:0005634) 12359327 nucleus 50 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms BRWD3 HGNC:17342 bromodomain and WD repeat domain containing 3 Q6RI45 Nucleus (GO:0005634) 17081983 nucleus 53 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms BSCL2 HGNC:15832 Berardinelli-Seip congenital lipodystrophy 2 (seipin) Q96G97 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11479539 endoplasmic reticulum membrane 100 4 endoplasmic reticulum membrane. plasma membrane multiple Theria Eukaryota Eukaryota BSDC1 HGNC:25501 BSD domain containing 1 Q9NW68 cytoplasm 11 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota BSG HGNC:1116 basigin (Ok blood group) P35613 Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/1634773,9360995,9767135 plasma membrane 16 1 cytoplasm. melanosome. nucleus. plasma membrane multiple Euteleostomi Bilateria Metazoa BSN HGNC:1117 bassoon presynaptic cytomatrix protein Q9UPA5 Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density (By similarity). Nucleus (GO:0005634) 9806829 secreted 29 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Craniata BSND HGNC:16512 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Q8WZ55 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity). Plasma membrane (GO:0005886) 11687798 plasma membrane 67 2 plasma membrane plasma membrane Eutheria Tetrapoda Craniata BSPH1 HGNC:33906 binder of sperm protein homolog 1 Q075Z2 Secreted (Probable). secreted 35 0 secreted secreted Eutheria Eutheria Holozoa BSPRY HGNC:18232 B-box and SPRY domain containing Q5W0U4 Cytoplasm. Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737) 12615066 secreted 12 0 cytoplasm cytoplasm Amniota Euteleostomi Deuterostomia BST1 HGNC:1118 bone marrow stromal cell antigen 1 Q10588 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8941363,8630113,11439087 cytoplasm 17 0 secreted secreted Amniota Deuterostomia Holozoa BST2 HGNC:1119 bone marrow stromal cell antigen 2 Q10589 Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane (By similarity). Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm. Plasma membrane (GO:0005886) 7607676 plasma membrane 26 2 cytoplasm. endosome. golgi apparatus. plasma membrane multiple Eutheria Eutheria Boreoeutheria BSX HGNC:20450 brain-specific homeobox Q3C1V8 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17353277,17353277 nucleus 44 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota BTAF1 HGNC:17307 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa O14981 Nucleus. Nucleus (GO:0005634) none,15561729 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms BTBD1 HGNC:1120 BTB (POZ) domain containing 1 Q9H0C5 Cytoplasm, P-body. Note=Cytoplasmic bodies. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12878161,15486563,15486563 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota BTBD10 HGNC:21445 BTB (POZ) domain containing 10 Q9BSF8 Nucleus. Nucleus (GO:0005634) 15556295 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota BTBD11 HGNC:23844 BTB (POZ) domain containing 11 A6QL63 Membrane; Single-pass membrane protein (Potential). nucleus 24 1 nucleus nucleus Euteleostomi Bilateria Cell.Organisms BTBD16 HGNC:26340 BTB (POZ) domain containing 16 Q32M84 cytoplasm 10 1 cytoplasm cytoplasm Mammalia Deuterostomia Holozoa BTBD17 HGNC:33758 BTB (POZ) domain containing 17 A6NE02 Secreted (Potential). cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa BTBD18 HGNC:37214 BTB (POZ) domain containing 18 B2RXH4 nucleus 15 0 nucleus nucleus NA NA Metazoa BTBD19 HGNC:27145 BTB (POZ) domain containing 19 C9JJ37 nucleus 17 0 nucleus nucleus NA NA Eukaryota BTBD2 HGNC:15504 BTB (POZ) domain containing 2 Q9BX70 Cytoplasm, P-body. Note=Cytoplasmic bodies. Nucleus (GO:0005634) 11818025 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota BTBD3 HGNC:15854 BTB (POZ) domain containing 3 Q9Y2F9 cytoplasm 70 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota BTBD6 HGNC:19897 BTB (POZ) domain containing 6 Q96KE9 Cytoplasm, P-body (By similarity). Note=Cytoplasmic bodies (By similarity). cytoplasm 84 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota BTBD7 HGNC:18269 BTB (POZ) domain containing 7 Q9P203 Nucleus (GO:0005634) 11527404 nucleus 17 0 nucleus nucleus Bilateria Bilateria Metazoa BTBD8 HGNC:21019 BTB (POZ) domain containing 8 Q5XKL5 Nucleus. Note=Localized to nucleus in fetal cells. nucleus 100 0 nucleus nucleus Mammalia Chordata Eukaryota BTBD9 HGNC:21228 BTB (POZ) domain containing 9 Q96Q07 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms BTC HGNC:1121 betacellulin P35070 Betacellulin: Secreted, extracellular space. Probetacellulin: Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576) 8144591 plasma membrane 12 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi NA BTD HGNC:1122 biotinidase P43251 Secreted, extracellular space. Extracellular (GO:0005576) 10655158 secreted 100 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms BTF3 HGNC:1125 basic transcription factor 3 P20290 Nucleus. Nucleus (GO:0005634) 2320128 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota BTF3L4 HGNC:30547 basic transcription factor 3-like 4 Q96K17 nucleus 78 0 nucleus nucleus Eukaryota Eukaryota Eukaryota BTG1 HGNC:1130 B-cell translocation gene 1, anti-proliferative P62324 Nucleus (GO:0005634) 9820826 cytoplasm 32 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota BTG2 HGNC:1131 BTG family, member 2 P78543 Nucleus (GO:0005634) 11136725 cytoplasm 27 0 nucleus nucleus Theria Euteleostomi Eukaryota BTG3 HGNC:1132 BTG family, member 3 Q14201 Cytoplasm (GO:0005737) 9632145 cytoplasm 15 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota BTG4 HGNC:13862 B-cell translocation gene 4 Q9NY30 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota BTK HGNC:1133 Bruton agammaglobulinemia tyrosine kinase Q06187 Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 7907259,9333013,10373551 cytoplasm 42 0 cytoplasm. nucleus multiple Chordata Bilateria NA BTLA HGNC:21087 B and T lymphocyte associated Q7Z6A9 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12796776 plasma membrane 41 1 plasma membrane plasma membrane Eutheria Mammalia Amniota BTN1A1 HGNC:1135 butyrophilin, subfamily 1, member A1 Q13410 Membrane; Single-pass type I membrane protein. Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 6830779,8132890,10376248 plasma membrane 39 1 plasma membrane. secreted multiple Amniota Euteleostomi Bilateria BTN2A1 HGNC:1136 butyrophilin, subfamily 2, member A1 Q7KYR7 Membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) 9382921 plasma membrane 32 1 plasma membrane plasma membrane Eutheria Tetrapoda Bilateria BTN2A2 HGNC:1137 butyrophilin, subfamily 2, member A2 Q8WVV5 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 34 1 plasma membrane plasma membrane Eutheria Tetrapoda Bilateria BTN3A1 HGNC:1138 butyrophilin, subfamily 3, member A1 O00481 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Eutheria Bilateria BTN3A2 HGNC:1139 butyrophilin, subfamily 3, member A2 P78410 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 9382921 plasma membrane 100 1 plasma membrane plasma membrane Human Human Bilateria BTN3A3 HGNC:1140 butyrophilin, subfamily 3, member A3 O00478 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Eutheria Bilateria BTNL2 HGNC:1142 butyrophilin-like 2 (MHC class II associated) Q9UIR0 Membrane; Single-pass type II membrane protein. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound. plasma membrane 27 0 n/a n/a Eutheria Mammalia NA BTNL3 HGNC:1143 butyrophilin-like 3 Q6UXE8 Membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 22 1 plasma membrane plasma membrane Catarrhini Theria Chordata BTNL8 HGNC:26131 butyrophilin-like 8 Q6UX41 Membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) nucleus 20 1 nucleus nucleus Catarrhini Theria Chordata BTNL9 HGNC:24176 butyrophilin-like 9 Q6UXG8 Membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 28 1 plasma membrane plasma membrane Theria Theria Chordata BTRC HGNC:1144 beta-transducin repeat containing E3 ubiquitin protein ligase Q9Y297 Cytoplasm. Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9990852,10531035,10531035 cytoplasm 17 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms BUB1 HGNC:1148 BUB1 mitotic checkpoint serine/threonine kinase O43683 Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, CASC5 and INCENP are required for kinetochore localization (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Chromosome (GO:0005694); Kinetochore (GO:0000776) 9660858,9660858,17113138,11129339,9660858,15561729 nucleus 100 1 cytoplasm. nucleus multiple Human Bilateria Cell.Organisms BUB1B HGNC:1149 BUB1 mitotic checkpoint serine/threonine kinase B O60566 Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5. Kinetochore (GO:0000776); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Chromosome (GO:0005694) 15824131,17363900,16732327,15561729,9660858,11274370,10749118,9914370,9660858,11129339 nucleus 18 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota BUB3 HGNC:1151 BUB3 mitotic checkpoint protein O43684 Nucleus. Chromosome, centromere, kinetochore (By similarity). Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition (By similarity). Kinetochore (GO:0000776); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Mitochondrion (GO:0005739) 9660858,15561729,9660858,9660858,15635413,11129339,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Cell.Organisms BUD13 HGNC:28199 BUD13 homolog (S. cerevisiae) Q9BRD0 Nucleus (GO:0005634) 17081983 nucleus 16 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota BUD31 HGNC:29629 BUD31 homolog (S. cerevisiae) P41223 Nucleus (Potential). Nucleus (GO:0005634) 7841202 nucleus 55 0 nucleus nucleus Eukaryota Eukaryota Eukaryota BVES HGNC:1152 blood vessel epicardial substance Q8NE79 Lateral cell membrane. Cell junction, tight junction. Membrane; Multi-pass membrane protein (Potential). Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. Plasma membrane (GO:0005886) secreted 9 3 n/a n/a Deuterostomia Bilateria Eumetazoa BYSL HGNC:1157 bystin-like Q13895 Cytoplasm. Nucleus, nucleolus. Note=Associated with 40S ribosomal subunits. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 10026108,9560222,17081983,11790298,15635413,15561729,17081983 nucleus 75 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota BZRAP1 HGNC:16831 benzodiazepine receptor (peripheral) associated protein 1 O95153 Cytoplasm. Mitochondrion. Note=Preferentially expressed in the mitochondria in the presence of BZRP. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9915832,9915832 cytoplasm 11 0 cytoplasm. mitochondrion multiple Amniota Chordata Eukaryota BZW1 HGNC:18380 basic leucine zipper and W2 domains 1 Q7L1Q6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11524015,17081983,17081983 nucleus 75 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota BZW2 HGNC:18808 basic leucine zipper and W2 domains 2 Q9Y6E2 Nucleolus (GO:0005730) 15635413 nucleus 78 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota C10orf10 HGNC:23355 chromosome 10 open reading frame 10 Q9NTK1 nucleus 62 0 nucleus nucleus Theria Theria Mammalia C10orf105 HGNC:20304 chromosome 10 open reading frame 105 Q8TEF2 Membrane; Single-pass membrane protein (Potential). secreted 68 1 secreted secreted Homininae Homininae Amniota C10orf107 HGNC:28678 chromosome 10 open reading frame 107 Q8IVU9 cytoplasm 44 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Metazoa C10orf11 HGNC:23405 chromosome 10 open reading frame 11 Q9H2I8 nucleus 28 0 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms C10orf111 HGNC:28582 chromosome 10 open reading frame 111 Q8N326 Membrane; Single-pass membrane protein (Potential). secreted 47 1 secreted secreted Homininae Homininae Boreoeutheria C10orf113 HGNC:31447 chromosome 10 open reading frame 113 Q5VZT2 secreted 20 0 secreted secreted Homininae Homininae Eutheria C10orf118 HGNC:24349 chromosome 10 open reading frame 118 Q7Z3E2 cytoplasm 2 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa C10orf12 HGNC:23420 chromosome 10 open reading frame 12 Q8N655 Nucleus (GO:0005634) 17081983 nucleus 96 0 nucleus nucleus Catarrhini Amniota Craniata C10orf120 HGNC:25707 chromosome 10 open reading frame 120 Q5SQS8 nucleus 53 0 nucleus nucleus Theria Theria Mammalia C10orf128 HGNC:27274 chromosome 10 open reading frame 128 Q5T292 Membrane; Single-pass type I membrane protein. cytoplasm 15 1 cytoplasm cytoplasm Eutheria Amniota Eutheria C10orf129 HGNC:31665 chromosome 10 open reading frame 129 Q6P461 Mitochondrion (Potential). mitochondrion 34 2 mitochondrion mitochondrion Human Human Cell.Organisms C10orf131 HGNC:31667 chromosome 10 open reading frame 131 A6NCD4 cytoplasm 23 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa C10orf2 HGNC:1160 chromosome 10 open reading frame 2 Q96RR1 Mitochondrion matrix, mitochondrion nucleoid. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression. Mitochondrion (GO:0005739) 11431692 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms C10orf25 HGNC:23509 chromosome 10 open reading frame 25 Q5T742 Secreted (Potential). mitochondrion 9 0 mitochondrion mitochondrion Homininae Homininae Eutheria C10orf32 HGNC:23516 chromosome 10 open reading frame 32 Q96B45 nucleus 9 0 nucleus nucleus Amniota Bilateria Bilateria C10orf35 HGNC:23519 chromosome 10 open reading frame 35 Q96D05 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 41 1 golgi apparatus membrane golgi apparatus membrane Mammalia Chordata Eumetazoa C10orf53 HGNC:27421 chromosome 10 open reading frame 53 Q8N6V4 cytoplasm 19 0 cytoplasm cytoplasm Mammalia Deuterostomia Eumetazoa C10orf54 HGNC:30085 chromosome 10 open reading frame 54 Q9H7M9 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12975309 plasma membrane 75 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi C10orf55 HGNC:31008 chromosome 10 open reading frame 55 Q5SWW7 secreted 22 0 secreted secreted NA NA Eutheria C10orf62 HGNC:23294 chromosome 10 open reading frame 62 Q5T681 mitochondrion membrane 17 0 mitochondrion membrane mitochondrion membrane Human Mammalia Mammalia C10orf67 HGNC:28716 chromosome 10 open reading frame 67 Q8IYJ2 nucleus 26 0 nucleus nucleus Euarchontoglires Chordata Metazoa C10orf71 HGNC:26973 chromosome 10 open reading frame 71 Q711Q0 secreted 12 0 secreted secreted Amniota Amniota Euteleostomi C10orf76 HGNC:25788 chromosome 10 open reading frame 76 Q5T2E6 Membrane; Single-pass membrane protein (Potential). nucleus 24 4 nucleus nucleus Opisthokonta Eukaryota Eukaryota C10orf82 HGNC:28500 chromosome 10 open reading frame 82 Q8WW14 secreted 44 0 secreted secreted Mammalia Mammalia NA C10orf85 HGNC:31365 chromosome 10 open reading frame 85 Q8N1V8 secreted 80 0 secreted secreted Catarrhini Catarrhini Primates C10orf88 HGNC:25822 chromosome 10 open reading frame 88 Q9H8K7 secreted 37 0 secreted secreted Amniota Deuterostomia Deuterostomia C10orf90 HGNC:26563 chromosome 10 open reading frame 90 Q96M02 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin. cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Eumetazoa C10orf91 HGNC:27275 chromosome 10 open reading frame 91 Q5T1B1 secreted 42 0 secreted secreted Homininae Homininae Homo C10orf95 HGNC:25880 chromosome 10 open reading frame 95 Q9H7T3 nucleus 46 0 nucleus nucleus Homininae Homininae Homo C10orf99 HGNC:31428 chromosome 10 open reading frame 99 Q6UWK7 Secreted (Potential). Integral to membrane (GO:0016021) secreted 93 0 secreted secreted Homininae Eutheria Boreoeutheria C11orf1 HGNC:1163 chromosome 11 open reading frame 1 Q9H5F2 Nucleus. Nucleus (GO:0005634) 10873569 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia NA C11orf16 HGNC:1169 chromosome 11 open reading frame 16 Q9NQ32 nucleus 51 0 nucleus nucleus Theria Amniota Bilateria C11orf21 HGNC:13231 chromosome 11 open reading frame 21 Q9P2W6 Cytoplasm. Cytoplasm (GO:0005737) 11054561 cytoplasm 100 0 cytoplasm cytoplasm Homininae Homininae Euarchontoglires C11orf24 HGNC:1174 chromosome 11 open reading frame 24 Q96F05 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11401438 cytoplasm 18 1 plasma membrane plasma membrane Eutheria Eutheria Euteleostomi C11orf30 HGNC:18071 chromosome 11 open reading frame 30 Q7Z589 Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 14651845,14981236,14981236,14981236 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota C11orf31 HGNC:18251 chromosome 11 open reading frame 31 Q8IZQ5 nucleus 43 4 nucleus nucleus Catarrhini Bilateria Eukaryota C11orf35 HGNC:28561 chromosome 11 open reading frame 35 Q8IXW0 cytoplasm 79 0 cytoplasm cytoplasm Theria Theria Eumetazoa C11orf40 HGNC:23986 chromosome 11 open reading frame 40 Q8WZ69 secreted 60 0 secreted secreted Homininae Homininae Primates C11orf42 HGNC:28541 chromosome 11 open reading frame 42 Q8N5U0 cytoplasm 33 0 cytoplasm cytoplasm Theria Theria Chordata C11orf44 HGNC:26805 chromosome 11 open reading frame 44 Q8N8P7 Secreted (Potential). secreted 76 0 secreted secreted Homininae Homininae Boreoeutheria C11orf45 HGNC:28584 chromosome 11 open reading frame 45 Q8TAV5 Secreted (Potential). secreted 88 0 secreted secreted Homininae Homininae Primates C11orf48 HGNC:28351 chromosome 11 open reading frame 48 Q9BQE6 secreted 74 0 secreted secreted Human Euarchontoglires Eumetazoa C11orf49 HGNC:28720 chromosome 11 open reading frame 49 Q9H6J7 nucleus 63 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta C11orf52 HGNC:30531 chromosome 11 open reading frame 52 Q96A22 nucleus 50 0 nucleus nucleus Theria Amniota NA C11orf53 HGNC:30527 chromosome 11 open reading frame 53 Q8IXP5 nucleus 90 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi C11orf54 HGNC:30204 chromosome 11 open reading frame 54 Q9H0W9 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Opisthokonta Opisthokonta C11orf57 HGNC:25569 chromosome 11 open reading frame 57 Q6ZUT1 nucleus 3 0 nucleus nucleus Tetrapoda Deuterostomia NA C11orf58 HGNC:16990 chromosome 11 open reading frame 58 O00193 nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa C11orf63 HGNC:26288 chromosome 11 open reading frame 63 Q6NUN7 nucleus 93 0 nucleus nucleus Mammalia Euteleostomi Bilateria C11orf65 HGNC:28519 chromosome 11 open reading frame 65 Q8NCR3 nucleus 66 0 nucleus nucleus Theria Eukaryota Eukaryota C11orf68 HGNC:28801 chromosome 11 open reading frame 68 Q9H3H3 cytoplasm 27 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Opisthokonta C11orf70 HGNC:28188 chromosome 11 open reading frame 70 Q9BRQ4 cytoplasm 24 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota C11orf71 HGNC:25937 chromosome 11 open reading frame 71 Q6IPW1 mitochondrion 15 0 mitochondrion mitochondrion Eutheria Eutheria Craniata C11orf72 HGNC:26915 chromosome 11 open reading frame 72 Q8NBR9 secreted 38 0 secreted secreted Human Human Homo C11orf73 HGNC:26938 chromosome 11 open reading frame 73 Q53FT3 Cytoplasm, cytosol. Nucleus. cytoplasm 87 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota C11orf74 HGNC:25142 chromosome 11 open reading frame 74 Q86VG3 nucleus 54 0 nucleus nucleus Amniota Amniota Tetrapoda C11orf80 HGNC:26197 chromosome 11 open reading frame 80 Q8N6T0 nucleus 54 2 nucleus nucleus Mammalia Mammalia Opisthokonta C11orf82 HGNC:26351 chromosome 11 open reading frame 82 Q8IXT1 Cytoplasm (By similarity). Nucleus (By similarity). Note=Accumulates in the nucleus in response to stress (By similarity). nucleus 87 0 nucleus nucleus Amniota Chordata Eumetazoa C11orf83 HGNC:34399 chromosome 11 open reading frame 83 Q6UW78 Secreted (Probable). secreted 22 1 secreted secreted Theria Theria Eutheria C11orf84 HGNC:25115 chromosome 11 open reading frame 84 Q9BUA3 Nucleus (GO:0005634) 17081983 nucleus 54 0 nucleus nucleus Mammalia Mammalia Euteleostomi C11orf85 HGNC:27441 chromosome 11 open reading frame 85 Q3KP22 nucleus 64 0 nucleus nucleus Eutheria Mammalia Chordata C11orf86 HGNC:34442 chromosome 11 open reading frame 86 A6NJI1 nucleus 43 0 nucleus nucleus Mammalia Mammalia Mammalia C11orf87 HGNC:33788 chromosome 11 open reading frame 87 Q6NUJ2 Membrane; Single-pass type I membrane protein (Potential). secreted 36 1 secreted secreted Eutheria Amniota Tetrapoda C11orf88 HGNC:25061 chromosome 11 open reading frame 88 Q6PI97 nucleus 79 0 nucleus nucleus Theria Euteleostomi Bilateria C11orf89 HGNC:35118 chromosome 11 open reading frame 89 A8MZF0 secreted 16 0 secreted secreted Euarchontoglires Amniota Amniota C11orf91 HGNC:34444 chromosome 11 open reading frame 91 Q3C1V1 nucleus 23 0 nucleus nucleus Theria Amniota Amniota C11orf94 HGNC:37213 chromosome 11 open reading frame 94 C9JXX5 Secreted (Potential). secreted 77 0 secreted secreted NA NA Mammalia C11orf95 HGNC:28449 chromosome 11 open reading frame 95 C9JLR9 nucleus 76 0 nucleus nucleus NA NA NA C11orf96 HGNC:38675 chromosome 11 open reading frame 96 Q7Z7L8 nucleus 79 0 nucleus nucleus Human Amniota Amniota C12orf10 HGNC:17590 chromosome 12 open reading frame 10 Q9HB07 Nucleus. Mitochondrion. Cytosol (GO:0005829) 16263121 cytoplasm 28 0 cytoplasm. mitochondrion. nucleus multiple Eutheria Cell.Organisms Cell.Organisms C12orf29 HGNC:25322 chromosome 12 open reading frame 29 Q8N999 cytoplasm 25 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms C12orf36 HGNC:26598 chromosome 12 open reading frame 36 Q495D7 secreted 12 0 secreted secreted Homininae Homininae Eutheria C12orf39 HGNC:28139 chromosome 12 open reading frame 39 Q9BT56 Secreted. Cytoplasmic vesicle, secretory vesicle. secreted 91 0 secreted secreted Eutheria Euteleostomi Euteleostomi C12orf4 HGNC:1184 chromosome 12 open reading frame 4 Q9NQ89 cytoplasm 3 1 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota C12orf40 HGNC:26846 chromosome 12 open reading frame 40 Q86WS4 nucleus 85 0 nucleus nucleus Catarrhini Mammalia Metazoa C12orf42 HGNC:24729 chromosome 12 open reading frame 42 Q96LP6 nucleus 53 0 nucleus nucleus Euarchontoglires Euarchontoglires Eutheria C12orf43 HGNC:25719 chromosome 12 open reading frame 43 Q96C57 Nucleus (GO:0005634) 17081983 nucleus 98 0 nucleus nucleus Chordata Chordata Bilateria C12orf45 HGNC:28628 chromosome 12 open reading frame 45 Q8N5I9 nucleus 93 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa C12orf49 HGNC:26128 chromosome 12 open reading frame 49 Q9H741 Secreted (Potential). secreted 74 0 secreted secreted Euteleostomi Eukaryota Eukaryota C12orf5 HGNC:1185 chromosome 12 open reading frame 5 Q9NQ88 cytoplasm 28 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms C12orf50 HGNC:26665 chromosome 12 open reading frame 50 Q8NA57 nucleus 52 0 nucleus nucleus Amniota Amniota Eukaryota C12orf54 HGNC:28553 chromosome 12 open reading frame 54 Q6X4T0 nucleus 25 0 nucleus nucleus Human Eutheria Eutheria C12orf55 HGNC:26456 chromosome 12 open reading frame 55 Q96N23 nucleus 79 2 nucleus nucleus Mammalia Eukaryota Eukaryota C12orf56 HGNC:26967 chromosome 12 open reading frame 56 Q8IXR9 nucleus 74 3 nucleus nucleus Eutheria Euteleostomi Holozoa C12orf57 HGNC:29521 chromosome 12 open reading frame 57 Q99622 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria NA C12orf60 HGNC:28726 chromosome 12 open reading frame 60 Q5U649 nucleus 50 0 nucleus nucleus Eutheria Amniota Amniota C12orf61 HGNC:26364 chromosome 12 open reading frame 61 Q8N7H1 secreted 50 0 secreted secreted NA NA Eutheria C12orf65 HGNC:26784 chromosome 12 open reading frame 65 Q9H3J6 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms C12orf66 HGNC:26517 chromosome 12 open reading frame 66 Q96MD2 nucleus 31 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C12orf71 HGNC:34452 chromosome 12 open reading frame 71 A8MTZ7 nucleus 83 0 nucleus nucleus Theria Theria Mammalia C12orf73 HGNC:34450 chromosome 12 open reading frame 73 Q69YU5 Secreted (Potential). secreted 11 0 secreted secreted Euarchontoglires Euteleostomi Chordata C12orf74 HGNC:27887 chromosome 12 open reading frame 74 Q32Q52 nucleus 80 0 nucleus nucleus Catarrhini Eutheria Boreoeutheria C12orf75 HGNC:35164 chromosome 12 open reading frame 75 Q8TAD7 secreted 21 0 secreted secreted NA NA Euteleostomi C12orf76 HGNC:33790 chromosome 12 open reading frame 76 Q8N812 secreted 75 0 secreted secreted Catarrhini Catarrhini Opisthokonta C12orf77 HGNC:27282 chromosome 12 open reading frame 77 C9JDV5 secreted 20 0 secreted secreted NA NA Primates C12orf79 HGNC:27409 chromosome 12 open reading frame 79 G3V211 secreted 26 1 secreted secreted NA NA Primates C14orf1 HGNC:1187 chromosome 14 open reading frame 1 Q9UKR5 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10449901 endoplasmic reticulum membrane 28 4 plasma membrane plasma membrane Euteleostomi Eukaryota Eukaryota C14orf105 HGNC:20189 chromosome 14 open reading frame 105 Q9NVL8 nucleus 69 0 nucleus nucleus Amniota Amniota Opisthokonta C14orf119 HGNC:20270 chromosome 14 open reading frame 119 Q9NWQ9 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Bilateria Eumetazoa C14orf132 HGNC:20346 chromosome 14 open reading frame 132 Q9NPU4 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 81 1 secreted secreted NA NA Homo C14orf142 HGNC:20356 chromosome 14 open reading frame 142 Q9BXV9 nucleus 32 0 nucleus nucleus Homininae Euarchontoglires Boreoeutheria C14orf159 HGNC:20498 chromosome 14 open reading frame 159 Q7Z3D6 Mitochondrion (Potential). cytoplasm 57 1 cytoplasm cytoplasm Human Cell.Organisms Cell.Organisms C14orf164 HGNC:20438 chromosome 14 open reading frame 164 A8MTL3 nucleus 17 0 nucleus nucleus Mammalia Mammalia Eukaryota C14orf166 HGNC:23169 chromosome 14 open reading frame 166 Q9Y224 Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytosol (GO:0005829) 15147888,15635413,15561729 nucleus 39 0 cytoplasm. nucleus multiple Bilateria Eukaryota Holozoa C14orf169 HGNC:20968 chromosome 14 open reading frame 169 Q9H6W3 Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli. Nucleolus (GO:0005730); Nucleus (GO:0005634) 14742713,15635413,14742713 nucleus 100 0 nucleus nucleus NA NA NA C14orf177 HGNC:26375 chromosome 14 open reading frame 177 Q52M58 secreted 64 0 secreted secreted Catarrhini Catarrhini Boreoeutheria C14orf178 HGNC:26385 chromosome 14 open reading frame 178 Q8N769 endoplasmic reticulum membrane 54 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Catarrhini Boreoeutheria C14orf180 HGNC:33795 chromosome 14 open reading frame 180 Q8N912 Cell membrane; Single-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 42 2 plasma membrane plasma membrane Eutheria Amniota Boreoeutheria C14orf182 HGNC:27503 chromosome 14 open reading frame 182 A1A4T8 secreted 23 0 secreted secreted Catarrhini Catarrhini Eutheria C14orf183 HGNC:27285 chromosome 14 open reading frame 183 Q8WXQ3 secreted 91 0 secreted secreted NA NA Eutheria C14orf2 HGNC:1188 chromosome 14 open reading frame 2 P56378 Mitochondrion (By similarity). Mitochondrion membrane; Single-pass membrane protein (Potential). mitochondrion 75 1 mitochondrion mitochondrion Amniota Amniota Olfactores C14orf28 HGNC:19834 chromosome 14 open reading frame 28 Q4W4Y0 nucleus 16 0 nucleus nucleus Mammalia Euteleostomi Craniata C14orf37 HGNC:19846 chromosome 14 open reading frame 37 Q86TY3 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 22 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Amniota Euteleostomi C14orf39 HGNC:19849 chromosome 14 open reading frame 39 Q8N1H7 cytoplasm 7 0 cytoplasm cytoplasm Amniota Amniota Amniota C14orf79 HGNC:20126 chromosome 14 open reading frame 79 Q96F83 cytoplasm 6 0 cytoplasm cytoplasm Eutheria Amniota Amniota C14orf80 HGNC:20127 chromosome 14 open reading frame 80 Q86SX3 nucleus 60 0 nucleus nucleus Theria Amniota NA C14orf93 HGNC:20162 chromosome 14 open reading frame 93 Q9H972 Secreted (Potential). nucleus 71 0 nucleus nucleus Mammalia Tetrapoda Eumetazoa C15orf26 HGNC:26782 chromosome 15 open reading frame 26 Q6P656 cytoplasm 39 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota C15orf27 HGNC:26763 chromosome 15 open reading frame 27 Q2M3C6 Membrane; Multi-pass membrane protein (Potential). nucleus 17 3 nucleus nucleus Chordata Chordata Metazoa C15orf32 HGNC:26549 chromosome 15 open reading frame 32 Q32M92 nucleus 8 1 nucleus nucleus Homininae Homininae Eutheria C15orf37 HGNC:27521 chromosome 15 open reading frame 37 Q8NBB2 nucleus 23 0 nucleus nucleus NA NA Homo C15orf38 HGNC:28782 chromosome 15 open reading frame 38 Q7Z6K5 cytoplasm 43 0 cytoplasm cytoplasm NA NA Eukaryota C15orf39 HGNC:24497 chromosome 15 open reading frame 39 Q6ZRI6 cytoplasm 12 0 cytoplasm cytoplasm Theria Euteleostomi Craniata C15orf40 HGNC:28443 chromosome 15 open reading frame 40 Q8WUR7 cytoplasm 28 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms C15orf41 HGNC:26929 chromosome 15 open reading frame 41 Q9Y2V0 nucleus 25 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms C15orf43 HGNC:28520 chromosome 15 open reading frame 43 Q8NHR7 cytoplasm 20 0 cytoplasm cytoplasm Mammalia Deuterostomia Holozoa C15orf48 HGNC:29898 chromosome 15 open reading frame 48 Q9C002 Nucleus. Nucleus (GO:0005634) 12209954 nucleus 100 1 nucleus nucleus Amniota Euteleostomi Holozoa C15orf52 HGNC:33488 chromosome 15 open reading frame 52 Q6ZUT6 nucleus 81 0 nucleus nucleus Amniota Amniota Bilateria C15orf53 HGNC:33796 chromosome 15 open reading frame 53 Q8NAA6 secreted 9 0 secreted secreted Homininae Homininae Eutheria C15orf54 HGNC:33797 chromosome 15 open reading frame 54 Q8N8G6 secreted 15 1 secreted secreted Human Human Boreoeutheria C15orf56 HGNC:33868 chromosome 15 open reading frame 56 Q8N910 secreted 60 0 secreted secreted Homininae Homininae Eutheria C15orf57 HGNC:28295 chromosome 15 open reading frame 57 Q9BV29 nucleus 64 0 nucleus nucleus Tetrapoda Tetrapoda Bilateria C15orf59 HGNC:33753 chromosome 15 open reading frame 59 Q2T9L4 nucleus 77 0 nucleus nucleus Euteleostomi Euteleostomi Craniata C15orf60 HGNC:25065 chromosome 15 open reading frame 60 Q7Z4M0 nucleus 33 0 nucleus nucleus Amniota Euteleostomi Bilateria C15orf61 HGNC:34453 chromosome 15 open reading frame 61 A6NNL5 Secreted (Potential). secreted 9 0 secreted secreted Euarchontoglires Bilateria Eumetazoa C15orf62 HGNC:34489 chromosome 15 open reading frame 62 A8K5M9 Mitochondrion (Potential). nucleus 46 0 nucleus nucleus Theria Amniota Amniota C15orf65 HGNC:44654 chromosome 15 open reading frame 65 H3BRN8 secreted 60 0 secreted secreted NA NA Metazoa C16orf11 HGNC:14139 chromosome 16 open reading frame 11 P0CG20 nucleus 41 0 nucleus nucleus Theria Euteleostomi Craniata C16orf13 HGNC:14141 chromosome 16 open reading frame 13 Q96S19 nucleus 24 0 nucleus nucleus NA NA Cell.Organisms C16orf3 HGNC:1197 chromosome 16 open reading frame 3 O95177 Cytoplasm (GO:0005737) 9790751 secreted 72 0 cytoplasm cytoplasm NA NA Homo C16orf45 HGNC:19213 chromosome 16 open reading frame 45 Q96MC5 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa C16orf46 HGNC:26525 chromosome 16 open reading frame 46 Q6P387 nucleus 69 0 nucleus nucleus Mammalia Mammalia Euteleostomi C16orf47 HGNC:28329 chromosome 16 open reading frame 47 Q6ZP98 nucleus 18 0 nucleus nucleus Homininae Homininae Eutheria C16orf52 HGNC:27087 chromosome 16 open reading frame 52 Q8NHV5 plasma membrane 29 1 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa C16orf54 HGNC:26649 chromosome 16 open reading frame 54 Q6UWD8 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) cytoplasm 21 1 cytoplasm cytoplasm Mammalia Mammalia Mammalia C16orf58 HGNC:25848 chromosome 16 open reading frame 58 Q96GQ5 Membrane; Single-pass membrane protein (Potential). secreted 14 4 n/a n/a Eukaryota Eukaryota Eukaryota C16orf59 HGNC:25849 chromosome 16 open reading frame 59 Q7L2K0 nucleus 72 0 nucleus nucleus Theria Euteleostomi Chordata C16orf62 HGNC:24641 chromosome 16 open reading frame 62 Q7Z3J2 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) 17081983 nucleus 80 0 nucleus nucleus Bilateria Eukaryota Eukaryota C16orf70 HGNC:29564 chromosome 16 open reading frame 70 Q9BSU1 mitochondrion 8 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota C16orf71 HGNC:25081 chromosome 16 open reading frame 71 Q8IYS4 nucleus 90 0 nucleus nucleus Eutheria Mammalia Mammalia C16orf72 HGNC:30103 chromosome 16 open reading frame 72 Q14CZ0 nucleus 63 0 nucleus nucleus Theria Bilateria Metazoa C16orf74 HGNC:23362 chromosome 16 open reading frame 74 Q96GX8 secreted 49 0 secreted secreted Mammalia Mammalia Mammalia C16orf78 HGNC:28479 chromosome 16 open reading frame 78 Q8WTQ4 nucleus 69 0 nucleus nucleus Eutheria Eutheria Deuterostomia C16orf80 HGNC:29523 chromosome 16 open reading frame 80 Q9Y6A4 nucleus 13 0 nucleus nucleus Bilateria Eukaryota Eukaryota C16orf86 HGNC:33755 chromosome 16 open reading frame 86 Q6ZW13 nucleus 48 0 nucleus nucleus Homininae Homininae Boreoeutheria C16orf87 HGNC:33754 chromosome 16 open reading frame 87 Q6PH81 nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa C16orf89 HGNC:28687 chromosome 16 open reading frame 89 Q6UX73 Secreted. secreted 100 0 secreted secreted Amniota Bilateria Opisthokonta C16orf90 HGNC:34455 chromosome 16 open reading frame 90 A8MZG2 secreted 83 0 secreted secreted Eutheria Mammalia Mammalia C16orf91 HGNC:27558 chromosome 16 open reading frame 91 Q4G0I0 Membrane; Single-pass type I membrane protein (Potential). secreted 16 1 secreted secreted NA NA Deuterostomia C16orf92 HGNC:26346 chromosome 16 open reading frame 92 Q96LL3 Membrane; Single-pass membrane protein (Potential). secreted 50 1 secreted secreted Eutheria Eutheria Eutheria C16orf93 HGNC:28078 chromosome 16 open reading frame 93 A1A4V9 nucleus 49 0 nucleus nucleus Theria Eukaryota Eukaryota C16orf95 HGNC:40033 chromosome 16 open reading frame 95 Q9H693 secreted 73 0 secreted secreted NA NA Eutheria C16orf96 HGNC:40031 chromosome 16 open reading frame 96 A6NNT2 secreted 23 0 secreted secreted Theria Amniota Metazoa C16orf97 HGNC:44658 chromosome 16 open reading frame 97 H3BN30 secreted 59 2 n/a n/a NA NA Primates C17orf100 HGNC:34494 chromosome 17 open reading frame 100 A8MU93 nucleus 74 0 nucleus nucleus Homininae Euarchontoglires Euarchontoglires C17orf102 HGNC:34412 chromosome 17 open reading frame 102 A2RUQ5 secreted 61 0 secreted secreted Homininae Homininae Eutheria C17orf103 HGNC:30770 chromosome 17 open reading frame 103 Q8N6N6 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms C17orf104 HGNC:26670 chromosome 17 open reading frame 104 A2RUB1 nucleus 88 0 nucleus nucleus Tetrapoda Chordata Eumetazoa C17orf105 HGNC:37241 chromosome 17 open reading frame 105 B2RV13 nucleus 25 0 nucleus nucleus NA NA Eukaryota C17orf107 HGNC:37238 chromosome 17 open reading frame 107 Q6ZR85 secreted 18 0 secreted secreted Euarchontoglires Euarchontoglires Eutheria C17orf112 HGNC:42963 chromosome 17 open reading frame 112 F2Z3M2 secreted 20 0 secreted secreted NA NA Homo C17orf47 HGNC:26844 chromosome 17 open reading frame 47 Q8NEP4 nucleus 49 0 nucleus nucleus Mammalia Mammalia Mammalia C17orf49 HGNC:28737 chromosome 17 open reading frame 49 Q8IXM2 Nucleus (Potential). Nucleus (GO:0005634) nucleus 62 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa C17orf50 HGNC:29581 chromosome 17 open reading frame 50 Q8WW18 nucleus 61 0 nucleus nucleus Euarchontoglires Euarchontoglires NA C17orf51 HGNC:27904 chromosome 17 open reading frame 51 A8MQB3 secreted 61 0 secreted secreted NA NA NA C17orf53 HGNC:28460 chromosome 17 open reading frame 53 Q8N3J3 cytoplasm 51 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota C17orf58 HGNC:27568 chromosome 17 open reading frame 58 Q2M2W7 secreted 22 0 secreted secreted Amniota Euteleostomi NA C17orf59 HGNC:25939 chromosome 17 open reading frame 59 Q96GS4 nucleus 83 0 nucleus nucleus Bilateria Bilateria Eumetazoa C17orf62 HGNC:28672 chromosome 17 open reading frame 62 Q9BQA9 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) 17081983 endoplasmic reticulum membrane 10 2 nucleus nucleus Euteleostomi Deuterostomia Eukaryota C17orf64 HGNC:26990 chromosome 17 open reading frame 64 Q86WR6 nucleus 30 0 nucleus nucleus Amniota Amniota Opisthokonta C17orf66 HGNC:26548 chromosome 17 open reading frame 66 A2RTY3 nucleus 41 0 nucleus nucleus Eutheria Eutheria NA C17orf67 HGNC:27900 chromosome 17 open reading frame 67 Q0P5P2 Secreted (Potential). secreted 87 0 secreted secreted Euarchontoglires Amniota Euteleostomi C17orf70 HGNC:26171 chromosome 17 open reading frame 70 Q0VG06 Nucleus. Nucleus (GO:0005634) 17396147 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa C17orf72 HGNC:25673 chromosome 17 open reading frame 72 P0C7W0 secreted 32 0 secreted secreted NA NA Euteleostomi C17orf74 HGNC:27315 chromosome 17 open reading frame 74 Q0P670 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 73 1 nucleus nucleus Euarchontoglires Eutheria Eutheria C17orf75 HGNC:30173 chromosome 17 open reading frame 75 Q9HAS0 nucleus 66 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota C17orf77 HGNC:26480 chromosome 17 open reading frame 77 Q96MU5 Secreted (Potential). secreted 59 1 secreted secreted Homininae Homininae Homo C17orf78 HGNC:26831 chromosome 17 open reading frame 78 Q8N4C9 Membrane; Single-pass membrane protein (Potential). nucleus 17 1 nucleus nucleus Theria Amniota Mammalia C17orf80 HGNC:29601 chromosome 17 open reading frame 80 Q9BSJ5 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 74 1 nucleus nucleus Mammalia Mammalia Euteleostomi C17orf82 HGNC:32699 chromosome 17 open reading frame 82 Q86X59 secreted 57 0 secreted secreted Homininae Homininae Euarchontoglires C17orf85 HGNC:24612 chromosome 17 open reading frame 85 Q53F19 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 96 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota C17orf89 HGNC:33551 chromosome 17 open reading frame 89 A1L188 secreted 47 0 secreted secreted NA NA Euteleostomi C17orf96 HGNC:34493 chromosome 17 open reading frame 96 A6NHQ4 secreted 20 0 secreted secreted Theria Theria Euteleostomi C17orf97 HGNC:33800 chromosome 17 open reading frame 97 Q6ZQX7 secreted 23 0 secreted secreted Euarchontoglires Eutheria NA C17orf98 HGNC:34492 chromosome 17 open reading frame 98 A8MV24 nucleus 25 0 nucleus nucleus Theria Deuterostomia Metazoa C17orf99 HGNC:34490 chromosome 17 open reading frame 99 Q6UX52 Secreted (Probable). plasma membrane 45 0 secreted secreted Euarchontoglires Mammalia Mammalia C18orf21 HGNC:28802 chromosome 18 open reading frame 21 Q32NC0 nucleus 66 0 nucleus nucleus Chordata Chordata Bilateria C18orf25 HGNC:28172 chromosome 18 open reading frame 25 Q96B23 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 94 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata C18orf32 HGNC:31690 chromosome 18 open reading frame 32 Q8TCD1 secreted 11 0 secreted secreted Tetrapoda Euteleostomi Bilateria C18orf42 HGNC:28285 chromosome 18 open reading frame 42 P0CW23 nucleus 26 0 nucleus nucleus NA NA Amniota C18orf54 HGNC:13796 chromosome 18 open reading frame 54 Q8IYD9 Secreted (Potential). nucleus 81 0 nucleus nucleus Mammalia Euteleostomi Bilateria C18orf56 HGNC:29553 chromosome 18 open reading frame 56 Q8TAI1 secreted 67 0 secreted secreted Human Human Homo C18orf63 HGNC:40037 chromosome 18 open reading frame 63 Q68DL7 nucleus 75 0 nucleus nucleus Amniota Chordata Metazoa C18orf64 HGNC:44660 chromosome 18 open reading frame 64 J3KSC0 secreted 75 0 secreted secreted NA NA NA C18orf8 HGNC:24326 chromosome 18 open reading frame 8 Q96DM3 Nucleus (GO:0005634) 17081983 nucleus 47 0 nucleus nucleus Bilateria Eukaryota Eukaryota C19orf10 HGNC:16948 chromosome 19 open reading frame 10 Q969H8 Secreted. Endoplasmic reticulum-Golgi intermediate compartment. secreted 84 0 secreted secreted Amniota Deuterostomia Eukaryota C19orf12 HGNC:25443 chromosome 19 open reading frame 12 Q9NSK7 Mitochondrion. Mitochondrion membrane; Single-pass membrane protein (Potential). cytoplasm 8 2 mitochondrion mitochondrion Euteleostomi Bilateria Bilateria C19orf18 HGNC:28642 chromosome 19 open reading frame 18 Q8NEA5 Membrane; Single-pass type I membrane protein (Potential). nucleus 27 1 nucleus nucleus Euarchontoglires Eutheria Eutheria C19orf24 HGNC:26073 chromosome 19 open reading frame 24 Q9BVV8 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 28 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Bilateria C19orf25 HGNC:26711 chromosome 19 open reading frame 25 Q9UFG5 cytoplasm 41 0 cytoplasm cytoplasm Chordata Chordata Chordata C19orf26 HGNC:28617 chromosome 19 open reading frame 26 Q8N350 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) ,17081983 nucleus 57 1 nucleus nucleus Theria Euteleostomi Craniata C19orf33 HGNC:16668 chromosome 19 open reading frame 33 Q9GZP8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11606055,17081983 nucleus 100 0 cytoplasm. nucleus multiple Catarrhini Euarchontoglires Boreoeutheria C19orf35 HGNC:24793 chromosome 19 open reading frame 35 Q6ZS72 cytoplasm 38 1 cytoplasm cytoplasm Theria Theria Euteleostomi C19orf38 HGNC:34073 chromosome 19 open reading frame 38 A8MVS5 Membrane; Single-pass type I membrane protein. secreted 41 1 secreted secreted Mammalia Mammalia Mammalia C19orf40 HGNC:28467 chromosome 19 open reading frame 40 Q9BTP7 Nucleus. Nucleus (GO:0005634); Cytosol (GO:0005829) 17289582,17289582 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms C19orf43 HGNC:28424 chromosome 19 open reading frame 43 Q9BQ61 nucleus 58 0 nucleus nucleus Theria Bilateria Bilateria C19orf44 HGNC:26141 chromosome 19 open reading frame 44 Q9H6X5 nucleus 5 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa C19orf45 HGNC:24745 chromosome 19 open reading frame 45 Q8NA69 nucleus 24 0 nucleus nucleus Mammalia Deuterostomia Eumetazoa C19orf47 HGNC:26723 chromosome 19 open reading frame 47 Q8N9M1 cytoplasm 31 0 cytoplasm cytoplasm Euteleostomi Bilateria Holozoa C19orf48 HGNC:29667 chromosome 19 open reading frame 48 Q6RUI8 secreted 59 0 secreted secreted Homininae Homininae Boreoeutheria C19orf52 HGNC:25152 chromosome 19 open reading frame 52 Q9BSF4 nucleus 19 0 nucleus nucleus Eutheria Bilateria Metazoa C19orf53 HGNC:24991 chromosome 19 open reading frame 53 Q9UNZ5 Nucleolus (GO:0005730) 15635413 nucleus 46 0 nucleus nucleus Theria Deuterostomia Deuterostomia C19orf54 HGNC:24758 chromosome 19 open reading frame 54 Q5BKX5 cytoplasm 42 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota C19orf55 HGNC:25204 chromosome 19 open reading frame 55 Q2NL68 nucleus 69 0 nucleus nucleus Eutheria Eutheria Chordata C19orf57 HGNC:28153 chromosome 19 open reading frame 57 Q0VDD7 nucleus 89 0 nucleus nucleus Eutheria Eutheria Eutheria C19orf59 HGNC:27291 chromosome 19 open reading frame 59 Q8IX19 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 15953541 secreted 30 1 plasma membrane plasma membrane Eutheria Eutheria Eutheria C19orf60 HGNC:26098 chromosome 19 open reading frame 60 Q96EN9 nucleus 29 0 nucleus nucleus Eutheria Eukaryota Eukaryota C19orf66 HGNC:25649 chromosome 19 open reading frame 66 Q9NUL5 nucleus 75 0 nucleus nucleus Theria Euteleostomi Holozoa C19orf67 HGNC:34354 chromosome 19 open reading frame 67 A6NJJ6 nucleus 57 0 nucleus nucleus Theria Euteleostomi Euteleostomi C19orf68 HGNC:34495 chromosome 19 open reading frame 68 Q86XI8 cytoplasm 25 0 cytoplasm cytoplasm Mammalia Mammalia Tetrapoda C19orf70 HGNC:33702 chromosome 19 open reading frame 70 Q5XKP0 mitochondrion 20 1 mitochondrion mitochondrion Theria Euteleostomi Bilateria C19orf71 HGNC:34496 chromosome 19 open reading frame 71 A6NCJ1 secreted 14 0 secreted secreted Mammalia Mammalia Mammalia C19orf73 HGNC:25534 chromosome 19 open reading frame 73 Q9NVV2 cytoplasm 16 0 cytoplasm cytoplasm NA NA Boreoeutheria C19orf80 HGNC:24933 chromosome 19 open reading frame 80 Q6UXH0 Secreted. secreted 100 0 secreted secreted Mammalia Mammalia Mammalia C19orf81 HGNC:40041 chromosome 19 open reading frame 81 C9J6K1 nucleus 56 0 nucleus nucleus NA NA Bilateria C19orf82 HGNC:27613 chromosome 19 open reading frame 82 K7EIQ3 secreted 26 0 secreted secreted NA NA NA C19orf83 HGNC:48331 chromosome 19 open reading frame 83 K7EIZ4 nucleus 19 0 nucleus nucleus NA NA NA C19orf84 HGNC:27112 chromosome 19 open reading frame 84 I3L1E1 secreted 37 0 secreted secreted NA NA Primates C1D HGNC:29911 C1D nuclear receptor corepressor Q13901 Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11801738,9469821,11801738 nucleus 56 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota C1GALT1 HGNC:24337 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 Q9NS00 Membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 9 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota C1GALT1C1 HGNC:24338 C1GALT1-specific chaperone 1 Q96EU7 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 12464682 endoplasmic reticulum membrane 10 1 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota C1orf100 HGNC:30435 chromosome 1 open reading frame 100 Q5SVJ3 secreted 14 0 secreted secreted Amniota Amniota Amniota C1orf101 HGNC:28491 chromosome 1 open reading frame 101 Q5SY80 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 64 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Bilateria Metazoa C1orf105 HGNC:29591 chromosome 1 open reading frame 105 O95561 nucleus 19 0 nucleus nucleus Catarrhini Eutheria Eutheria C1orf106 HGNC:25599 chromosome 1 open reading frame 106 Q3KP66 cytoplasm 25 0 cytoplasm cytoplasm Amniota Euteleostomi Bilateria C1orf109 HGNC:26039 chromosome 1 open reading frame 109 Q9NX04 nucleus 53 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa C1orf110 HGNC:28736 chromosome 1 open reading frame 110 Q86UF4 nucleus 75 0 nucleus nucleus Theria Theria Mammalia C1orf111 HGNC:27648 chromosome 1 open reading frame 111 Q5T0L3 nucleus 27 0 nucleus nucleus Amniota Amniota Euteleostomi C1orf112 HGNC:25565 chromosome 1 open reading frame 112 Q9NSG2 secreted 35 0 secreted secreted Deuterostomia Deuterostomia Holozoa C1orf115 HGNC:25873 chromosome 1 open reading frame 115 Q9H7X2 Membrane; Single-pass membrane protein (Potential). nucleus 81 1 nucleus nucleus Amniota Amniota Mammalia C1orf116 HGNC:28667 chromosome 1 open reading frame 116 Q9BW04 Cytoplasm. Cytoplasm (GO:0005737) 15525603 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Euteleostomi C1orf122 HGNC:24789 chromosome 1 open reading frame 122 Q6ZSJ8 secreted 77 0 secreted secreted Catarrhini Catarrhini Eutheria C1orf123 HGNC:26059 chromosome 1 open reading frame 123 Q9NWV4 secreted 39 0 secreted secreted Eukaryota Eukaryota Eukaryota C1orf127 HGNC:26730 chromosome 1 open reading frame 127 Q8N9H9 nucleus 17 0 nucleus nucleus Euarchontoglires Euarchontoglires Euteleostomi C1orf131 HGNC:25332 chromosome 1 open reading frame 131 Q8NDD1 nucleus 98 0 nucleus nucleus Deuterostomia Bilateria Bilateria C1orf134 HGNC:32021 chromosome 1 open reading frame 134 Q5TEV5 Secreted (Potential). cytoplasm 15 0 cytoplasm cytoplasm Homininae Homininae Homo C1orf137 HGNC:32040 chromosome 1 open reading frame 137 Q5JT78 secreted 83 0 secreted secreted Homininae Homininae Primates C1orf141 HGNC:32044 chromosome 1 open reading frame 141 Q5JVX7 nucleus 58 0 nucleus nucleus Euarchontoglires Eutheria Eutheria C1orf146 HGNC:24032 chromosome 1 open reading frame 146 Q5VVC0 cytoplasm 23 1 cytoplasm cytoplasm Theria Euteleostomi Bilateria C1orf147 HGNC:32061 chromosome 1 open reading frame 147 Q96MC9 secreted 65 0 secreted secreted Homininae Homininae NA C1orf158 HGNC:28567 chromosome 1 open reading frame 158 Q8N1D5 nucleus 30 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa C1orf159 HGNC:26062 chromosome 1 open reading frame 159 Q96HA4 Membrane; Single-pass membrane protein (Potential). nucleus 26 1 nucleus nucleus Tetrapoda Euteleostomi Euteleostomi C1orf162 HGNC:28344 chromosome 1 open reading frame 162 Q8NEQ5 Membrane; Single-pass membrane protein (Potential). secreted 52 1 secreted secreted Euarchontoglires Eutheria Eutheria C1orf167 HGNC:25262 chromosome 1 open reading frame 167 Q5SNV9 nucleus 88 2 nucleus nucleus Catarrhini Eutheria Eutheria C1orf168 HGNC:27295 chromosome 1 open reading frame 168 Q5VWT5 nucleus 91 0 nucleus nucleus Eutheria Amniota Euteleostomi C1orf172 HGNC:26624 chromosome 1 open reading frame 172 Q8NAX2 nucleus 80 0 nucleus nucleus Tetrapoda Euteleostomi Craniata C1orf174 HGNC:27915 chromosome 1 open reading frame 174 Q8IYL3 Nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Craniata C1orf177 HGNC:26854 chromosome 1 open reading frame 177 Q3ZCV2 nucleus 26 0 nucleus nucleus Tetrapoda Chordata Metazoa C1orf185 HGNC:28096 chromosome 1 open reading frame 185 Q5T7R7 Membrane; Single-pass membrane protein (Potential). nucleus 23 1 nucleus nucleus Euarchontoglires Eutheria Eutheria C1orf186 HGNC:25341 chromosome 1 open reading frame 186 Q6ZWK4 Membrane; Single-pass membrane protein (Potential). nucleus 28 1 nucleus nucleus Catarrhini Eutheria NA C1orf189 HGNC:32305 chromosome 1 open reading frame 189 Q5VU69 cytoplasm 22 0 cytoplasm cytoplasm Theria Theria Chordata C1orf192 HGNC:32325 chromosome 1 open reading frame 192 Q5VTH2 nucleus 54 0 nucleus nucleus Theria Eukaryota Metazoa C1orf194 HGNC:32331 chromosome 1 open reading frame 194 Q5T5A4 secreted 13 0 secreted secreted Mammalia Bilateria Metazoa C1orf195 HGNC:32332 chromosome 1 open reading frame 195 Q5TG92 secreted 14 0 secreted secreted Homininae Homininae Boreoeutheria C1orf198 HGNC:25900 chromosome 1 open reading frame 198 Q9H425 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa C1orf200 HGNC:32346 chromosome 1 open reading frame 200 Q5SR53 secreted 67 0 secreted secreted Catarrhini Catarrhini Euarchontoglires C1orf204 HGNC:27647 chromosome 1 open reading frame 204 Q5VU13 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 18 1 plasma membrane plasma membrane Mammalia Mammalia Mammalia C1orf21 HGNC:15494 chromosome 1 open reading frame 21 Q9H246 cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria C1orf210 HGNC:28755 chromosome 1 open reading frame 210 Q8IVY1 Membrane; Single-pass membrane protein (Potential). plasma membrane 39 1 plasma membrane plasma membrane NA NA Tetrapoda C1orf216 HGNC:26800 chromosome 1 open reading frame 216 Q8TAB5 nucleus 55 0 nucleus nucleus Tetrapoda Tetrapoda Craniata C1orf220 HGNC:33805 chromosome 1 open reading frame 220 Q5T0J3 nucleus 19 0 nucleus nucleus Homininae Homininae Homo C1orf222 HGNC:27917 chromosome 1 open reading frame 222 Q69YW0 secreted 21 0 secreted secreted Amniota Eukaryota Eukaryota C1orf226 HGNC:34351 chromosome 1 open reading frame 226 A1L170 nucleus 58 0 nucleus nucleus NA NA Euteleostomi C1orf228 HGNC:34345 chromosome 1 open reading frame 228 Q6PIY5 nucleus 50 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota C1orf229 HGNC:33759 chromosome 1 open reading frame 229 Q6ZS94 secreted 31 0 secreted secreted NA NA Homo C1orf233 HGNC:42951 chromosome 1 open reading frame 233 F2Z333 Membrane; Single-pass type I membrane protein (Potential). secreted 98 1 secreted secreted NA NA Craniata C1orf234 HGNC:44651 chromosome 1 open reading frame 234 H3BTG2 secreted 55 1 secreted secreted NA NA Boreoeutheria C1orf27 HGNC:24299 chromosome 1 open reading frame 27 Q5SWX8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 29 2 plasma membrane plasma membrane Tetrapoda Eukaryota Eukaryota C1orf35 HGNC:19032 chromosome 1 open reading frame 35 Q9BU76 Nucleus (GO:0005634); Nucleolus (GO:0005730) 12545221,15635413 nucleus 96 0 nucleus nucleus Eutheria Eukaryota Eukaryota C1orf43 HGNC:29876 chromosome 1 open reading frame 43 Q9BWL3 Membrane; Single-pass membrane protein (Potential). nucleus 19 1 nucleus nucleus Deuterostomia Bilateria Eumetazoa C1orf50 HGNC:28795 chromosome 1 open reading frame 50 Q9BV19 cytoplasm 19 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms C1orf52 HGNC:24871 chromosome 1 open reading frame 52 Q8N6N3 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 89 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Chordata C1orf53 HGNC:30003 chromosome 1 open reading frame 53 Q5VUE5 mitochondrion 10 0 mitochondrion mitochondrion Euarchontoglires Eukaryota Cell.Organisms C1orf54 HGNC:26258 chromosome 1 open reading frame 54 Q8WWF1 Secreted (Potential). secreted 44 0 secreted secreted Theria Theria NA C1orf56 HGNC:26045 chromosome 1 open reading frame 56 Q9BUN1 Secreted (Potential). nucleus 38 0 nucleus nucleus Eutheria Eutheria Mammalia C1orf61 HGNC:30780 chromosome 1 open reading frame 61 Q13536 Nucleus. Note=Associates within the nuclear transcriptional apparatus during proliferation and differentiation. Nucleus (GO:0005634) 10995546 nucleus 100 1 nucleus nucleus Catarrhini Catarrhini Eutheria C1orf64 HGNC:28339 chromosome 1 open reading frame 64 Q8NEQ6 cytoplasm 30 0 cytoplasm cytoplasm Eutheria Eutheria Eutheria C1orf65 HGNC:26654 chromosome 1 open reading frame 65 Q8N715 cytoplasm 13 0 cytoplasm cytoplasm Mammalia Euteleostomi Amniota C1orf68 HGNC:29468 chromosome 1 open reading frame 68 Q5T750 cytoplasm 31 0 cytoplasm cytoplasm Euarchontoglires Euarchontoglires Eukaryota C1orf74 HGNC:26319 chromosome 1 open reading frame 74 Q96LT6 secreted 70 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa C1orf85 HGNC:29436 chromosome 1 open reading frame 85 Q8WWB7 Lysosome membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 46 1 lysosome membrane lysosome membrane Deuterostomia Bilateria Holozoa C1orf86 HGNC:26428 chromosome 1 open reading frame 86 Q6NZ36 Nucleus. Chromosome. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Bilateria C1orf87 HGNC:28547 chromosome 1 open reading frame 87 Q8N0U7 nucleus 67 0 nucleus nucleus Theria Theria Eumetazoa C1orf94 HGNC:28250 chromosome 1 open reading frame 94 Q6P1W5 nucleus 77 0 nucleus nucleus Amniota Amniota Amniota C1orf95 HGNC:30491 chromosome 1 open reading frame 95 Q69YW2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 15 2 mitochondrion membrane mitochondrion membrane Euarchontoglires Eukaryota Eumetazoa C1QA HGNC:1241 complement component 1, q subcomponent, A chain P02745 Secreted. Extracellular (GO:0005576) 7939135 secreted 100 0 secreted secreted Human Euteleostomi Cell.Organisms C1QB HGNC:1242 complement component 1, q subcomponent, B chain P02746 Secreted. Extracellular (GO:0005576) 7939135 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Bilateria C1QBP HGNC:1243 complement component 1, q subcomponent binding protein Q07021 Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10831594,10097078,15598749,12220632,12220632,12220632,9299613,12220632,11866440,92299613 mitochondrion 98 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus. secreted multiple Bilateria Bilateria Opisthokonta C1QC HGNC:1245 complement component 1, q subcomponent, C chain P02747 Secreted. Extracellular (GO:0005576) 7939135 secreted 100 0 secreted secreted Amniota Euteleostomi Bilateria C1QL1 HGNC:24182 complement component 1, q subcomponent-like 1 O75973 Secreted. Cytoplasm (GO:0005737) 9878755 secreted 100 0 cytoplasm. secreted multiple Theria Euteleostomi Bilateria C1QL2 HGNC:24181 complement component 1, q subcomponent-like 2 Q7Z5L3 Secreted (By similarity). secreted 93 0 secreted secreted Theria Euteleostomi Bilateria C1QL3 HGNC:19359 complement component 1, q subcomponent-like 3 Q5VWW1 Secreted (By similarity). secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria C1QL4 HGNC:31416 complement component 1, q subcomponent-like 4 Q86Z23 Secreted (By similarity). secreted 96 0 secreted secreted Theria Euteleostomi Bilateria C1QTNF1 HGNC:14324 C1q and tumor necrosis factor related protein 1 Q9BXJ1 Secreted (Potential). Plasma membrane (GO:0005886) 12409230 secreted 44 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms C1QTNF2 HGNC:14325 C1q and tumor necrosis factor related protein 2 Q9BXJ5 Secreted (Potential). plasma membrane 36 0 n/a n/a Amniota Euteleostomi Bilateria C1QTNF3 HGNC:14326 C1q and tumor necrosis factor related protein 3 Q9BXJ4 Secreted (Potential). Extracellular (GO:0005576) 11071891 secreted 41 0 secreted secreted Human Cell.Organisms Bilateria C1QTNF4 HGNC:14346 C1q and tumor necrosis factor related protein 4 Q9BXJ3 Secreted. secreted 100 0 secreted secreted Euteleostomi Deuterostomia Bilateria C1QTNF5 HGNC:14344 C1q and tumor necrosis factor related protein 5 Q9BXJ0 Secreted (Probable). Extracellular (GO:0005576) 12944416 secreted 32 0 secreted secreted NA NA Bilateria C1QTNF6 HGNC:14343 C1q and tumor necrosis factor related protein 6 Q9BXI9 Secreted (Probable). Cytoplasm (GO:0005737) 12975309 secreted 43 0 cytoplasm. secreted multiple Chordata Chordata Bilateria C1QTNF7 HGNC:14342 C1q and tumor necrosis factor related protein 7 Q9BXJ2 Secreted (Potential). secreted 52 0 secreted secreted Tetrapoda Euteleostomi Bilateria C1QTNF8 HGNC:31374 C1q and tumor necrosis factor related protein 8 P60827 Secreted. secreted 100 0 secreted secreted Catarrhini Amniota Bilateria C1QTNF9 HGNC:28732 C1q and tumor necrosis factor related protein 9 P0C862 Secreted (By similarity). secreted 97 0 secreted secreted NA NA Cell.Organisms C1QTNF9B HGNC:34072 C1q and tumor necrosis factor related protein 9B B2RNN3 Secreted. Note=Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum. secreted 100 0 secreted secreted NA NA Cell.Organisms C1R HGNC:1246 complement component 1, r subcomponent P00736 Extracellular (GO:0005576) 16188874 secreted 34 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms C1RL HGNC:21265 complement component 1, r subcomponent-like Q9NZP8 Secreted. secreted 100 0 secreted secreted Mammalia Tetrapoda Cell.Organisms C1S HGNC:1247 complement component 1, s subcomponent P09871 Extracellular (GO:0005576) 10630213,16188874 secreted 71 0 secreted secreted Tetrapoda Bilateria NA C2 HGNC:1248 complement component 2 P06681 Secreted. Extracellular (GO:0005576) 8621452,10734221 secreted 100 0 secreted secreted Euarchontoglires Deuterostomia NA C20orf112 HGNC:16106 chromosome 20 open reading frame 112 Q96MY1 nucleus 51 0 nucleus nucleus Theria Deuterostomia Metazoa C20orf141 HGNC:16134 chromosome 20 open reading frame 141 Q9NUB4 Membrane; Single-pass membrane protein (Potential). secreted 47 2 n/a n/a NA NA Boreoeutheria C20orf144 HGNC:16137 chromosome 20 open reading frame 144 Q9BQM9 nucleus 58 0 nucleus nucleus Theria Theria Mammalia C20orf166 HGNC:16159 chromosome 20 open reading frame 166 Q9H1L0 secreted 80 0 secreted secreted Homininae Homininae NA C20orf173 HGNC:16166 chromosome 20 open reading frame 173 Q96LM9 secreted 61 0 secreted secreted Catarrhini Eutheria Eutheria C20orf194 HGNC:17721 chromosome 20 open reading frame 194 Q5TEA3 nucleus 30 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C20orf195 HGNC:28764 chromosome 20 open reading frame 195 Q9BVV2 nucleus 54 0 nucleus nucleus Euarchontoglires Amniota Craniata C20orf196 HGNC:26318 chromosome 20 open reading frame 196 Q8IYI0 nucleus 60 0 nucleus nucleus Theria Theria Amniota C20orf197 HGNC:26601 chromosome 20 open reading frame 197 Q8N268 secreted 22 0 secreted secreted Homininae Homininae Homo C20orf202 HGNC:37254 chromosome 20 open reading frame 202 A1L168 nucleus 24 0 nucleus nucleus Homininae Euarchontoglires Boreoeutheria C20orf203 HGNC:26592 chromosome 20 open reading frame 203 Q8NBC4 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm NA NA NA C20orf24 HGNC:15870 chromosome 20 open reading frame 24 Q9BUV8 endoplasmic reticulum membrane 48 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota C20orf26 HGNC:15872 chromosome 20 open reading frame 26 Q8NHU2 cytoplasm 51 1 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota C20orf27 HGNC:15873 chromosome 20 open reading frame 27 Q9GZN8 cytoplasm 53 0 cytoplasm cytoplasm Eutheria Bilateria Metazoa C20orf78 HGNC:16210 chromosome 20 open reading frame 78 Q9BR46 secreted 43 0 secreted secreted Homininae Homininae Primates C20orf85 HGNC:16216 chromosome 20 open reading frame 85 Q9H1P6 cytoplasm 24 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Metazoa C20orf96 HGNC:16227 chromosome 20 open reading frame 96 Q9NUD7 cytoplasm 11 0 cytoplasm cytoplasm Theria Euteleostomi Bilateria C21orf128 HGNC:23821 chromosome 21 open reading frame 128 Q8N2C9 secreted 56 0 secreted secreted Homininae Homininae Eutheria C21orf140 HGNC:39602 chromosome 21 open reading frame 140 B9A014 nucleus 20 0 nucleus nucleus NA NA Metazoa C21orf2 HGNC:1260 chromosome 21 open reading frame 2 O43822 Mitochondrion (GO:0005739) 9325172 cytoplasm 26 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms C21orf33 HGNC:1273 chromosome 21 open reading frame 33 P30042 Mitochondrion (Potential). Mitochondrion (GO:0005739) 9150728,15082224,15598749 mitochondrion 34 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms C21orf58 HGNC:1300 chromosome 21 open reading frame 58 P58505 nucleus 82 0 nucleus nucleus Tetrapoda Euteleostomi Euteleostomi C21orf59 HGNC:1301 chromosome 21 open reading frame 59 P57076 nucleus 38 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C21orf62 HGNC:1305 chromosome 21 open reading frame 62 Q9NYP8 secreted 58 0 secreted secreted Tetrapoda Tetrapoda NA C21orf91 HGNC:16459 chromosome 21 open reading frame 91 Q9NYK6 nucleus 59 0 nucleus nucleus Euteleostomi Euteleostomi Chordata C22orf15 HGNC:15558 chromosome 22 open reading frame 15 Q8WYQ4 nucleus 59 0 nucleus nucleus Euarchontoglires Chordata Bilateria C22orf23 HGNC:18589 chromosome 22 open reading frame 23 Q9BZE7 nucleus 65 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta C22orf24 HGNC:23051 chromosome 22 open reading frame 24 Q9Y442 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 64 1 secreted secreted Catarrhini Catarrhini Euarchontoglires C22orf26 HGNC:25606 chromosome 22 open reading frame 26 Q9NV39 secreted 30 0 secreted secreted Homininae Homininae Homo C22orf29 HGNC:26112 chromosome 22 open reading frame 29 Q7L3V2 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Catarrhini Catarrhini Eutheria C22orf31 HGNC:26931 chromosome 22 open reading frame 31 O95567 nucleus 54 0 nucleus nucleus Theria Theria Euteleostomi C22orf39 HGNC:27012 chromosome 22 open reading frame 39 Q6P5X5 secreted 50 0 secreted secreted NA NA NA C22orf42 HGNC:27160 chromosome 22 open reading frame 42 Q6IC83 secreted 59 0 secreted secreted Homininae Homininae Primates C22orf46 HGNC:26294 chromosome 22 open reading frame 46 C9J442 Secreted (Potential). secreted 78 0 secreted secreted NA NA Boreoeutheria C2CD2 HGNC:1266 C2 calcium-dependent domain containing 2 Q9Y426 Secreted (Potential). nucleus 32 1 nucleus nucleus Amniota Euteleostomi Bilateria C2CD2L HGNC:29000 C2CD2-like O14523 Membrane; Single-pass membrane protein (By similarity). Integral to membrane (GO:0016021) nucleus 29 1 nucleus nucleus Euteleostomi Euteleostomi Bilateria C2CD3 HGNC:24564 C2 calcium-dependent domain containing 3 Q4AC94 Nucleus (GO:0005634) 17081983 cytoplasm 71 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C2CD4A HGNC:33627 C2 calcium-dependent domain containing 4A Q8NCU7 Nucleus. Nucleus (GO:0005634) 15527968 nucleus 100 0 nucleus nucleus Theria Theria Euteleostomi C2CD4B HGNC:33628 C2 calcium-dependent domain containing 4B A6NLJ0 Nucleus. Nucleus (GO:0005634) 15527968 nucleus 100 0 nucleus nucleus Theria Theria Euteleostomi C2CD4C HGNC:29417 C2 calcium-dependent domain containing 4C Q8TF44 nucleus 26 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa C2CD4D HGNC:37210 C2 calcium-dependent domain containing 4D B7Z1M9 nucleus 27 0 nucleus nucleus NA NA Deuterostomia C2CD5 HGNC:29062 C2 calcium-dependent domain containing 5 Q86YS7 Cytoplasmic vesicle membrane. Cytoplasm, cell cortex. Cell membrane. Cell projection, ruffle. Note=Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 secreted 15 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota C2orf15 HGNC:28436 chromosome 2 open reading frame 15 Q8WU43 nucleus 15 1 nucleus nucleus NA NA Holozoa C2orf16 HGNC:25275 chromosome 2 open reading frame 16 Q68DN1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 18 0 cytoplasm cytoplasm NA NA Eutheria C2orf27A HGNC:25077 chromosome 2 open reading frame 27A Q580R0 secreted 64 0 secreted secreted Homininae Homininae Primates C2orf27B HGNC:33824 chromosome 2 open reading frame 27B Q580R0 secreted 64 0 secreted secreted NA NA Primates C2orf40 HGNC:24642 chromosome 2 open reading frame 40 Q9H1Z8 Secreted. Cytoplasmic vesicle, secretory vesicle. secreted 89 0 secreted secreted Euteleostomi Euteleostomi Craniata C2orf42 HGNC:26056 chromosome 2 open reading frame 42 Q9NWW7 nucleus 54 0 nucleus nucleus Euteleostomi Bilateria Bilateria C2orf43 HGNC:26145 chromosome 2 open reading frame 43 Q9H6V9 secreted 35 0 secreted secreted Eukaryota Eukaryota Eukaryota C2orf44 HGNC:26157 chromosome 2 open reading frame 44 Q9H6R7 nucleus 66 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria C2orf47 HGNC:26198 chromosome 2 open reading frame 47 Q8WWC4 Mitochondrion (Potential). mitochondrion 60 0 mitochondrion mitochondrion Tetrapoda Bilateria Eumetazoa C2orf48 HGNC:26322 chromosome 2 open reading frame 48 Q96LS8 secreted 64 0 secreted secreted Human Human Homo C2orf49 HGNC:28772 chromosome 2 open reading frame 49 Q9BVC5 Nucleus (GO:0005634) 17081983 nucleus 87 0 nucleus nucleus Euteleostomi Euteleostomi Craniata C2orf50 HGNC:26324 chromosome 2 open reading frame 50 Q96LR7 nucleus 63 0 nucleus nucleus Deuterostomia Deuterostomia Eumetazoa C2orf53 HGNC:28677 chromosome 2 open reading frame 53 Q53SZ7 nucleus 23 0 nucleus nucleus Euarchontoglires Euarchontoglires Eutheria C2orf54 HGNC:26216 chromosome 2 open reading frame 54 Q08AI8 nucleus 49 1 nucleus nucleus Amniota Amniota Deuterostomia C2orf57 HGNC:28563 chromosome 2 open reading frame 57 Q53QW1 nucleus 42 0 nucleus nucleus Homininae Eutheria Eutheria C2orf61 HGNC:26850 chromosome 2 open reading frame 61 Q8N801 mitochondrion 14 0 mitochondrion mitochondrion NA NA Metazoa C2orf66 HGNC:33809 chromosome 2 open reading frame 66 Q6UXQ4 Secreted (Potential). secreted 76 0 secreted secreted Theria Amniota Amniota C2orf68 HGNC:34353 chromosome 2 open reading frame 68 Q2NKX9 nucleus 63 0 nucleus nucleus Theria Deuterostomia Eumetazoa C2orf69 HGNC:26799 chromosome 2 open reading frame 69 Q8N8R5 Secreted (Potential). secreted 13 0 secreted secreted Euteleostomi Eukaryota Eukaryota C2orf70 HGNC:27938 chromosome 2 open reading frame 70 A6NJV1 nucleus 12 0 nucleus nucleus Amniota Deuterostomia Eumetazoa C2orf71 HGNC:34383 chromosome 2 open reading frame 71 A6NGG8 Cell projection, cilium, photoreceptor outer segment. secreted 27 0 secreted secreted Amniota Euteleostomi Craniata C2orf72 HGNC:27418 chromosome 2 open reading frame 72 A6NCS6 nucleus 42 0 nucleus nucleus Eutheria Eutheria Eutheria C2orf73 HGNC:26861 chromosome 2 open reading frame 73 Q8N5S3 nucleus 45 0 nucleus nucleus Theria Deuterostomia Metazoa C2orf74 HGNC:34439 chromosome 2 open reading frame 74 A8MZ97 Membrane; Single-pass membrane protein (Potential). secreted 60 1 secreted secreted NA NA Boreoeutheria C2orf76 HGNC:27017 chromosome 2 open reading frame 76 Q3KRA6 cytoplasm 27 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota C2orf78 HGNC:34349 chromosome 2 open reading frame 78 A6NCI8 secreted 15 0 secreted secreted Mammalia Mammalia Amniota C2orf80 HGNC:34352 chromosome 2 open reading frame 80 Q0P641 nucleus 32 0 nucleus nucleus Theria Theria Mammalia C2orf81 HGNC:34350 chromosome 2 open reading frame 81 A6NN90 nucleus 81 0 nucleus nucleus Theria Theria Opisthokonta C2orf82 HGNC:33763 chromosome 2 open reading frame 82 Q6UX34 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 42 1 secreted secreted Theria Amniota Amniota C2orf83 HGNC:25344 chromosome 2 open reading frame 83 Q53S99 mitochondrion membrane 11 0 mitochondrion membrane mitochondrion membrane Homininae Homininae Deuterostomia C2orf88 HGNC:28191 chromosome 2 open reading frame 88 Q9BSF0 Cell membrane. Note=The GFP-tagged protein has been detected at the plasma membrane, enriched in filopodia and cell-cell junctions (PubMed:23115245). cytoplasm 11 0 cytoplasm cytoplasm Theria Amniota Euteleostomi C2orf91 HGNC:42966 chromosome 2 open reading frame 91 Q6ZV80 secreted 38 0 secreted secreted NA NA Boreoeutheria C3 HGNC:1318 complement component 3 P01024 Secreted. Extracellular (GO:0005576); Endosome (GO:0005768) 11896391,16199891,16188874,16530040 secreted 100 0 endosome. secreted multiple Deuterostomia Deuterostomia Cell.Organisms C3AR1 HGNC:1319 complement component 3a receptor 1 Q16581 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11044372 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Amniota Eumetazoa C3orf14 HGNC:25024 chromosome 3 open reading frame 14 Q9HBI5 nucleus 24 0 nucleus nucleus Amniota Deuterostomia Bilateria C3orf17 HGNC:24496 chromosome 3 open reading frame 17 Q6NW34 Membrane; Single-pass membrane protein (Potential). nucleus 49 1 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa C3orf18 HGNC:24837 chromosome 3 open reading frame 18 Q9UK00 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 57 1 plasma membrane plasma membrane Amniota Euteleostomi Bilateria C3orf20 HGNC:25320 chromosome 3 open reading frame 20 Q8ND61 Membrane; Single-pass membrane protein (Potential). nucleus 63 1 nucleus nucleus Theria Chordata Holozoa C3orf22 HGNC:28534 chromosome 3 open reading frame 22 Q8N5N4 nucleus 59 0 nucleus nucleus Euarchontoglires Eutheria Eutheria C3orf27 HGNC:17099 chromosome 3 open reading frame 27 O15544 Nucleus (GO:0005634) 15067727 secreted 38 0 nucleus nucleus Homininae Homininae Boreoeutheria C3orf30 HGNC:26553 chromosome 3 open reading frame 30 Q96M34 nucleus 13 0 nucleus nucleus Eutheria Eutheria Holozoa C3orf33 HGNC:26434 chromosome 3 open reading frame 33 Q6P1S2 Membrane; Single-pass membrane protein (Potential). mitochondrion 21 1 mitochondrion mitochondrion Bilateria Bilateria Opisthokonta C3orf35 HGNC:24082 chromosome 3 open reading frame 35 Q8IVJ8 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 29 1 secreted secreted Catarrhini Catarrhini Primates C3orf36 HGNC:26170 chromosome 3 open reading frame 36 Q3SXR2 secreted 17 0 secreted secreted NA NA Boreoeutheria C3orf38 HGNC:28384 chromosome 3 open reading frame 38 Q5JPI3 nucleus 39 0 nucleus nucleus Deuterostomia Bilateria Holozoa C3orf52 HGNC:26255 chromosome 3 open reading frame 52 Q5BVD1 Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 55 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi C3orf55 HGNC:25146 chromosome 3 open reading frame 55 A1A4F0 vacuole membrane 21 2 vacuole membrane vacuole membrane Opisthokonta Eukaryota Eukaryota C3orf56 HGNC:32481 chromosome 3 open reading frame 56 Q8N813 nucleus 67 1 nucleus nucleus Catarrhini Catarrhini Primates C3orf58 HGNC:28490 chromosome 3 open reading frame 58 Q8NDZ4 Secreted (Potential). secreted 62 0 secreted secreted Euteleostomi Bilateria Eumetazoa C3orf62 HGNC:24771 chromosome 3 open reading frame 62 Q6ZUJ4 nucleus 63 0 nucleus nucleus Theria Theria Amniota C3orf67 HGNC:24763 chromosome 3 open reading frame 67 Q6ZVT6 nucleus 90 0 nucleus nucleus Chordata Eukaryota Eukaryota C3orf70 HGNC:33731 chromosome 3 open reading frame 70 A6NLC5 nucleus 47 0 nucleus nucleus Euteleostomi Euteleostomi Craniata C3orf72 HGNC:34428 chromosome 3 open reading frame 72 Q6ZUU3 mitochondrion 32 0 mitochondrion mitochondrion Homininae Homininae Eutheria C3orf79 HGNC:37259 chromosome 3 open reading frame 79 P0CE67 secreted 50 0 secreted secreted NA NA Eutheria C3orf80 HGNC:40048 chromosome 3 open reading frame 80 F5H4A9 Membrane; Single-pass membrane protein (Potential). secreted 97 1 secreted secreted NA NA Euteleostomi C3orf83 HGNC:40375 chromosome 3 open reading frame 83 H3BPM6 nucleus 21 0 nucleus nucleus NA NA Holozoa C3orf84 HGNC:44666 chromosome 3 open reading frame 84 H3BNL1 nucleus 35 0 nucleus nucleus NA NA Eumetazoa C4A HGNC:1323 complement component 4A (Rodgers blood group) P0C0L4 Secreted. Extracellular (GO:0005576) 6546707,16199891,16188874 secreted 100 0 secreted secreted NA NA NA C4B HGNC:1324 complement component 4B (Chido blood group) P0C0L5 Secreted. Extracellular (GO:0005576) 6546707,16188874 secreted 100 0 secreted secreted NA NA NA C4BPA HGNC:1325 complement component 4 binding protein, alpha P04003 Secreted. Extracellular (GO:0005576) 1989602,16188874 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Holozoa C4BPB HGNC:1328 complement component 4 binding protein, beta P20851 Secreted. Extracellular (GO:0005576) 2970465 secreted 100 0 secreted secreted Theria Theria Opisthokonta C4orf17 HGNC:25274 chromosome 4 open reading frame 17 Q53FE4 nucleus 69 0 nucleus nucleus Theria Amniota Eumetazoa C4orf19 HGNC:25618 chromosome 4 open reading frame 19 Q8IY42 nucleus 30 0 nucleus nucleus Theria Theria Amniota C4orf22 HGNC:28554 chromosome 4 open reading frame 22 Q6V702 cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota C4orf26 HGNC:26300 chromosome 4 open reading frame 26 Q17RF5 Secreted (Potential). secreted 60 0 secreted secreted Homininae Theria Mammalia C4orf27 HGNC:26051 chromosome 4 open reading frame 27 Q9NWY4 nucleus 64 0 nucleus nucleus Bilateria Bilateria Holozoa C4orf29 HGNC:26111 chromosome 4 open reading frame 29 Q0P651 Secreted (Potential). mitochondrion 24 2 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms C4orf3 HGNC:19225 chromosome 4 open reading frame 3 Q8WVX3 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 70 1 secreted secreted Euarchontoglires Eutheria Boreoeutheria C4orf32 HGNC:26813 chromosome 4 open reading frame 32 Q8N8J7 Membrane; Single-pass membrane protein (Potential). plasma membrane 17 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi C4orf33 HGNC:27025 chromosome 4 open reading frame 33 Q8N1A6 secreted 38 0 secreted secreted Euteleostomi Bilateria Cell.Organisms C4orf36 HGNC:28386 chromosome 4 open reading frame 36 Q96KX1 mitochondrion 42 0 mitochondrion mitochondrion Theria Theria Mammalia C4orf45 HGNC:26342 chromosome 4 open reading frame 45 Q96LM5 nucleus 27 0 nucleus nucleus Amniota Deuterostomia Metazoa C4orf46 HGNC:27320 chromosome 4 open reading frame 46 Q504U0 nucleus 41 0 nucleus nucleus Theria Amniota Amniota C4orf47 HGNC:34346 chromosome 4 open reading frame 47 A7E2U8 nucleus 24 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C4orf48 HGNC:34437 chromosome 4 open reading frame 48 Q5BLP8 Secreted (Potential). secreted 74 0 secreted secreted NA NA Craniata C4orf50 HGNC:33766 chromosome 4 open reading frame 50 Q6ZRC1 nucleus 51 0 nucleus nucleus Theria Amniota Euteleostomi C4orf51 HGNC:37264 chromosome 4 open reading frame 51 C9J302 nucleus 58 0 nucleus nucleus NA NA Boreoeutheria C4orf6 HGNC:13716 chromosome 4 open reading frame 6 Q99440 secreted 58 0 secreted secreted Homininae Homininae Homo C5 HGNC:1331 complement component 5 P01031 Secreted. Extracellular (GO:0005576) 7835913 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms C5AR1 HGNC:1338 complement component 5a receptor 1 P21730 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8573284,12600272 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Metazoa C5AR2 HGNC:4527 complement component 5a receptor 2 Q9P296 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa C5orf15 HGNC:20656 chromosome 5 open reading frame 15 Q8NC54 Membrane; Single-pass type I membrane protein (Potential). secreted 10 1 secreted secreted Tetrapoda Tetrapoda Bilateria C5orf17 HGNC:26630 chromosome 5 open reading frame 17 Q8NAS9 secreted 72 0 secreted secreted NA NA Homo C5orf20 HGNC:24459 chromosome 5 open reading frame 20 Q8TF63 Nucleus. Note=Particularly on the periphery. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11798177,11798177 nucleus 100 0 cytoplasm. nucleus multiple NA NA Eutheria C5orf22 HGNC:25639 chromosome 5 open reading frame 22 Q49AR2 nucleus 73 0 nucleus nucleus Deuterostomia Bilateria Holozoa C5orf24 HGNC:26746 chromosome 5 open reading frame 24 Q7Z6I8 nucleus 43 0 nucleus nucleus Euteleostomi Euteleostomi Craniata C5orf27 HGNC:24687 chromosome 5 open reading frame 27 Q52M75 secreted 73 0 secreted secreted NA NA Eutheria C5orf28 HGNC:26139 chromosome 5 open reading frame 28 Q0VDI3 Membrane; Multi-pass membrane protein (Potential). plasma membrane 35 7 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa C5orf30 HGNC:25052 chromosome 5 open reading frame 30 Q96GV9 Cytoplasm. Cell projection, cilium. Note=Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm. nucleus 57 0 cytoplasm cytoplasm Tetrapoda Euteleostomi NA C5orf34 HGNC:24738 chromosome 5 open reading frame 34 Q96MH7 nucleus 54 0 nucleus nucleus Amniota Deuterostomia Eumetazoa C5orf38 HGNC:24226 chromosome 5 open reading frame 38 Q86SI9 Secreted (Potential). secreted 72 0 secreted secreted Catarrhini Catarrhini Euarchontoglires C5orf42 HGNC:25801 chromosome 5 open reading frame 42 Q9H799 Membrane; Multi-pass membrane protein (Potential). nucleus 85 6 nucleus nucleus Tetrapoda Tetrapoda Eukaryota C5orf45 HGNC:30817 chromosome 5 open reading frame 45 Q6NTE8 nucleus 63 0 nucleus nucleus Eutheria Eutheria Eukaryota C5orf46 HGNC:33768 chromosome 5 open reading frame 46 Q6UWT4 Secreted (Potential). endoplasmic reticulum 21 0 endoplasmic reticulum endoplasmic reticulum Eutheria Eutheria Eutheria C5orf47 HGNC:27026 chromosome 5 open reading frame 47 Q569G3 nucleus 20 0 nucleus nucleus Euarchontoglires Euarchontoglires Boreoeutheria C5orf49 HGNC:27028 chromosome 5 open reading frame 49 A4QMS7 nucleus 15 0 nucleus nucleus Euarchontoglires Deuterostomia Holozoa C5orf51 HGNC:27750 chromosome 5 open reading frame 51 A6NDU8 nucleus 58 0 nucleus nucleus Amniota Deuterostomia Metazoa C5orf52 HGNC:35121 chromosome 5 open reading frame 52 A6NGY3 nucleus 35 0 nucleus nucleus Eutheria Eutheria Chordata C5orf54 HGNC:30804 chromosome 5 open reading frame 54 Q8IZ13 nucleus 7 1 nucleus nucleus NA NA Opisthokonta C5orf55 HGNC:25175 chromosome 5 open reading frame 55 Q8N2X6 Secreted (Potential). secreted 74 0 secreted secreted NA NA Primates C5orf56 HGNC:33838 chromosome 5 open reading frame 56 Q8N8D9 secreted 84 0 secreted secreted Human Human Eutheria C5orf58 HGNC:37272 chromosome 5 open reading frame 58 C9J3I9 nucleus 15 0 nucleus nucleus NA NA Boreoeutheria C5orf60 HGNC:27753 chromosome 5 open reading frame 60 A6NFR6 Membrane; Single-pass membrane protein (Potential). nucleus 23 1 nucleus nucleus Catarrhini Catarrhini Primates C5orf64 HGNC:26744 chromosome 5 open reading frame 64 Q2M2E5 Secreted (Potential). secreted 40 0 secreted secreted Homininae Homininae Eutheria C5orf66 HGNC:48332 chromosome 5 open reading frame 66 Q9H5L9 secreted 36 0 secreted secreted NA NA Eutheria C6 HGNC:1339 complement component 6 P13671 Secreted. Extracellular (GO:0005576) 2808363,3764345,16188874 secreted 100 0 secreted secreted Chordata Chordata Eukaryota C6orf1 HGNC:1340 chromosome 6 open reading frame 1 Q86T20 Secreted (Potential). secreted 58 0 secreted secreted Catarrhini Euarchontoglires Eutheria C6orf10 HGNC:13922 chromosome 6 open reading frame 10 Q5SRN2 Membrane; Multi-pass membrane protein (Potential). nucleus 8 2 nucleus nucleus Catarrhini Eutheria NA C6orf100 HGNC:21195 chromosome 6 open reading frame 100 Q5JQF7 secreted 56 0 secreted secreted NA NA NA C6orf106 HGNC:21215 chromosome 6 open reading frame 106 Q9H6K1 secreted 38 0 secreted secreted Amniota Eukaryota Cell.Organisms C6orf118 HGNC:21233 chromosome 6 open reading frame 118 Q5T5N4 nucleus 54 0 nucleus nucleus Mammalia Chordata Bilateria C6orf120 HGNC:21247 chromosome 6 open reading frame 120 Q7Z4R8 Secreted. Note=Secreted by hepatocytes. secreted 100 1 secreted secreted Chordata Chordata Eumetazoa C6orf123 HGNC:21235 chromosome 6 open reading frame 123 Q9Y6Z2 secreted 70 0 secreted secreted Homininae Homininae Homo C6orf132 HGNC:21288 chromosome 6 open reading frame 132 Q5T0Z8 plasma membrane 37 0 n/a n/a Mammalia Mammalia Amniota C6orf136 HGNC:21301 chromosome 6 open reading frame 136 Q5SQH8 nucleus 45 2 nucleus nucleus Deuterostomia Bilateria NA C6orf141 HGNC:21351 chromosome 6 open reading frame 141 Q5SZD1 secreted 20 0 secreted secreted Euarchontoglires Mammalia Mammalia C6orf15 HGNC:13927 chromosome 6 open reading frame 15 Q6UXA7 Secreted, extracellular space, extracellular matrix (By similarity). secreted 39 0 secreted secreted Theria Theria NA C6orf163 HGNC:21403 chromosome 6 open reading frame 163 Q5TEZ5 cytoplasm 7 0 cytoplasm cytoplasm Amniota Deuterostomia Chordata C6orf164 HGNC:21404 chromosome 6 open reading frame 164 Q5TEZ4 secreted 67 0 secreted secreted Homininae Homininae Primates C6orf165 HGNC:21405 chromosome 6 open reading frame 165 Q8IYR0 nucleus 30 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C6orf195 HGNC:21600 chromosome 6 open reading frame 195 Q96MT4 secreted 55 0 secreted secreted Homininae Homininae Primates C6orf201 HGNC:21620 chromosome 6 open reading frame 201 Q7Z4U5 nucleus 44 0 nucleus nucleus Euarchontoglires Eutheria Eutheria C6orf203 HGNC:17971 chromosome 6 open reading frame 203 Q9P0P8 nucleus 56 0 nucleus nucleus Deuterostomia Bilateria NA C6orf211 HGNC:17872 chromosome 6 open reading frame 211 Q9H993 secreted 19 0 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms C6orf222 HGNC:33769 chromosome 6 open reading frame 222 P0C671 nucleus 88 0 nucleus nucleus Eutheria Amniota Eutheria C6orf223 HGNC:28692 chromosome 6 open reading frame 223 Q8N319 mitochondrion 41 0 mitochondrion mitochondrion Catarrhini Catarrhini Eutheria C6orf226 HGNC:34431 chromosome 6 open reading frame 226 Q5I0X4 nucleus 22 0 nucleus nucleus NA NA Eutheria C6orf229 HGNC:49394 chromosome 6 open reading frame 229 H3BNL8 cytoplasm 21 0 cytoplasm cytoplasm NA NA Chordata C6orf25 HGNC:13937 chromosome 6 open reading frame 25 O95866 Isoform E: Endoplasmic reticulum. Golgi apparatus. Isoform D: Endoplasmic reticulum. Golgi apparatus. Isoform B: Cell membrane; Single-pass type I membrane protein. Isoform A: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11544253,11544253,11544253,11544253 plasma membrane 66 1 endoplasmic reticulum. golgi apparatus. plasma membrane. secreted multiple Theria Theria NA C6orf47 HGNC:19076 chromosome 6 open reading frame 47 O95873 secreted 70 3 n/a n/a Theria Theria NA C6orf48 HGNC:19078 chromosome 6 open reading frame 48 Q9UBA6 secreted 78 0 secreted secreted Homininae Homininae NA C6orf52 HGNC:20881 chromosome 6 open reading frame 52 Q5T4I8 nucleus 34 0 nucleus nucleus Catarrhini Catarrhini Bilateria C6orf57 HGNC:20957 chromosome 6 open reading frame 57 Q5VUM1 Secreted (Potential). mitochondrion 35 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms C6orf58 HGNC:20960 chromosome 6 open reading frame 58 Q6P5S2 Secreted (Potential). secreted 30 0 secreted secreted Amniota Eukaryota Eukaryota C6orf62 HGNC:20998 chromosome 6 open reading frame 62 Q9GZU0 nucleus 48 0 nucleus nucleus Chordata Chordata Eumetazoa C6orf89 HGNC:21114 chromosome 6 open reading frame 89 Q6UWU4 Isoform 1: Golgi apparatus membrane; Single- pass type II membrane protein. Midbody. Isoform 2: Cytoplasm. Nucleus, nucleolus. Note=Retained in nucleolar organiser regions (NORs) in mitotic cells. secreted 43 1 cytoplasm. golgi apparatus membrane. nucleus multiple Amniota Euteleostomi Deuterostomia C6orf99 HGNC:21179 chromosome 6 open reading frame 99 Q4VX62 secreted 80 0 secreted secreted Homininae Homininae Eutheria C7 HGNC:1346 complement component 7 P10643 Secreted. Extracellular (GO:0005576) 10886241,16188874 secreted 100 0 secreted secreted Amniota Euteleostomi Metazoa C7orf25 HGNC:21703 chromosome 7 open reading frame 25 Q9BPX7 Nucleus (GO:0005634) 17081983 cytoplasm 34 0 nucleus nucleus Bilateria Eukaryota Eukaryota C7orf26 HGNC:21702 chromosome 7 open reading frame 26 Q96N11 nucleus 41 1 nucleus nucleus Deuterostomia Bilateria Metazoa C7orf31 HGNC:21722 chromosome 7 open reading frame 31 Q8N865 nucleus 47 0 nucleus nucleus Amniota Deuterostomia Eumetazoa C7orf33 HGNC:21724 chromosome 7 open reading frame 33 Q8WU49 nucleus 9 0 nucleus nucleus Homininae Homininae Primates C7orf34 HGNC:21750 chromosome 7 open reading frame 34 Q96L11 Secreted (Potential). secreted 75 1 secreted secreted Human Theria NA C7orf43 HGNC:25604 chromosome 7 open reading frame 43 Q8WVR3 nucleus 34 0 nucleus nucleus Mammalia Euteleostomi Eumetazoa C7orf49 HGNC:22432 chromosome 7 open reading frame 49 Q9BWK5 Cytoplasm (By similarity). cytoplasm 59 0 cytoplasm cytoplasm Theria Theria Mammalia C7orf50 HGNC:22421 chromosome 7 open reading frame 50 Q9BRJ6 Nucleus (GO:0005634) 17081983 nucleus 96 0 nucleus nucleus Amniota Eukaryota Eukaryota C7orf55 HGNC:26946 chromosome 7 open reading frame 55 Q96HJ9 Nucleus (GO:0005634); Mitochondrion (GO:0005739) 16381901,16381901 mitochondrion 54 0 mitochondrion. nucleus multiple Amniota Bilateria Eumetazoa C7orf57 HGNC:22247 chromosome 7 open reading frame 57 Q8NEG2 nucleus 80 0 nucleus nucleus Amniota Chordata Eumetazoa C7orf60 HGNC:26475 chromosome 7 open reading frame 60 Q1RMZ1 nucleus 36 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C7orf61 HGNC:22135 chromosome 7 open reading frame 61 Q8IZ16 nucleus 55 1 nucleus nucleus Eutheria Eutheria Eutheria C7orf62 HGNC:22402 chromosome 7 open reading frame 62 Q8TBZ9 nucleus 62 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota C7orf63 HGNC:26107 chromosome 7 open reading frame 63 A5D8W1 nucleus 57 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota C7orf65 HGNC:34432 chromosome 7 open reading frame 65 Q6ZTY9 secreted 41 0 secreted secreted NA NA Boreoeutheria C7orf66 HGNC:33712 chromosome 7 open reading frame 66 A4D0T2 Membrane; Single-pass membrane protein (Potential). secreted 58 1 secreted secreted Homininae Homininae Eutheria C7orf69 HGNC:21911 chromosome 7 open reading frame 69 Q9H7B7 Secreted (Potential). secreted 51 1 secreted secreted Homininae Homininae Eutheria C7orf71 HGNC:22364 chromosome 7 open reading frame 71 A4D174 secreted 16 0 secreted secreted NA NA Primates C7orf72 HGNC:22564 chromosome 7 open reading frame 72 A4D263 nucleus 25 0 nucleus nucleus Mammalia Deuterostomia Metazoa C7orf73 HGNC:41909 chromosome 7 open reading frame 73 E0CX11 Secreted (Potential). mitochondrion 18 0 mitochondrion mitochondrion NA NA Craniata C7orf76 HGNC:33815 chromosome 7 open reading frame 76 Q6ZVN7 secreted 57 0 secreted secreted NA NA Eutheria C8A HGNC:1352 complement component 8, alpha polypeptide P07357 Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. Extracellular (GO:0005576) 11041874,16188874 plasma membrane 46 0 plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa C8B HGNC:1353 complement component 8, beta polypeptide P07358 Secreted. Extracellular (GO:0005576) 11041874,16199891,16188874 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Eumetazoa C8G HGNC:1354 complement component 8, gamma polypeptide P07360 Secreted. Extracellular (GO:0005576) 11058761,16188874 secreted 100 0 secreted secreted Amniota Euteleostomi Craniata C8orf17 HGNC:17737 chromosome 8 open reading frame 17 Q9NRJ1 Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane. secreted 15 0 cytoplasm cytoplasm NA NA Bilateria C8orf22 HGNC:31745 chromosome 8 open reading frame 22 Q8WWR9 secreted 27 0 secreted secreted Homininae Amniota Amniota C8orf31 HGNC:26731 chromosome 8 open reading frame 31 Q8N9H6 secreted 51 0 secreted secreted Homininae Homininae Euarchontoglires C8orf33 HGNC:26104 chromosome 8 open reading frame 33 Q9H7E9 nucleus 85 0 nucleus nucleus Eutheria Eukaryota Metazoa C8orf34 HGNC:30905 chromosome 8 open reading frame 34 Q49A92 nucleus 89 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa C8orf37 HGNC:27232 chromosome 8 open reading frame 37 Q96NL8 Cytoplasm. Note=In the retina, located at the base of the primary cilium. cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota C8orf4 HGNC:1357 chromosome 8 open reading frame 4 Q9NR00 nucleus 43 0 nucleus nucleus Euteleostomi Euteleostomi Craniata C8orf44 HGNC:25646 chromosome 8 open reading frame 44 Q96CB5 cytoplasm 20 0 cytoplasm cytoplasm Catarrhini Catarrhini Opisthokonta C8orf46 HGNC:28498 chromosome 8 open reading frame 46 Q8TAG6 nucleus 54 0 nucleus nucleus Amniota Amniota Amniota C8orf48 HGNC:26345 chromosome 8 open reading frame 48 Q96LL4 nucleus 89 0 nucleus nucleus Theria Theria Eumetazoa C8orf49 HGNC:32200 chromosome 8 open reading frame 49 Q96NF6 Membrane; Single-pass membrane protein (Potential). secreted 45 2 n/a n/a NA NA Bilateria C8orf58 HGNC:32233 chromosome 8 open reading frame 58 Q8NAV2 nucleus 52 0 nucleus nucleus NA NA Mammalia C8orf59 HGNC:32235 chromosome 8 open reading frame 59 Q8N0T1 mitochondrion 24 0 mitochondrion mitochondrion Mammalia Mammalia Euteleostomi C8orf74 HGNC:32296 chromosome 8 open reading frame 74 Q6P047 nucleus 49 0 nucleus nucleus Mammalia Deuterostomia Eumetazoa C8orf76 HGNC:25924 chromosome 8 open reading frame 76 Q96K31 nucleus 47 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa C8orf82 HGNC:33826 chromosome 8 open reading frame 82 Q6P1X6 mitochondrion 39 0 mitochondrion mitochondrion Theria Bilateria Cell.Organisms C8orf86 HGNC:33774 chromosome 8 open reading frame 86 Q6ZUL3 nucleus 28 0 nucleus nucleus Homininae Homininae Eutheria C8orf87 HGNC:42974 chromosome 8 open reading frame 87 E5RJ46 secreted 35 0 secreted secreted NA NA Primates C8orf88 HGNC:44672 chromosome 8 open reading frame 88 P0DMB2 nucleus 28 0 nucleus nucleus NA NA Euteleostomi C9 HGNC:1358 complement component 9 P02748 Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore. Extracellular (GO:0005576) 8471847,16188874 plasma membrane 29 0 plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa C9orf114 HGNC:26933 chromosome 9 open reading frame 114 Q5T280 Nucleolus (GO:0005730) 11790298 nucleus 46 0 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms C9orf116 HGNC:28435 chromosome 9 open reading frame 116 Q5BN46 secreted 44 0 secreted secreted Theria Eukaryota Opisthokonta C9orf117 HGNC:27843 chromosome 9 open reading frame 117 Q5JU67 cytoplasm 11 0 cytoplasm cytoplasm Deuterostomia Eukaryota Opisthokonta C9orf118 HGNC:25943 chromosome 9 open reading frame 118 A6NHY6 secreted 45 0 secreted secreted Catarrhini Catarrhini NA C9orf129 HGNC:31116 chromosome 9 open reading frame 129 Q5T035 nucleus 59 0 nucleus nucleus Catarrhini Mammalia Euteleostomi C9orf131 HGNC:31418 chromosome 9 open reading frame 131 Q5VYM1 nucleus 2 0 nucleus nucleus Euarchontoglires Eutheria Eutheria C9orf135 HGNC:31422 chromosome 9 open reading frame 135 Q5VTT2 Membrane; Single-pass membrane protein (Potential). nucleus 22 0 nucleus nucleus Mammalia Deuterostomia Metazoa C9orf139 HGNC:31426 chromosome 9 open reading frame 139 Q6ZV77 secreted 58 0 secreted secreted Human Human Boreoeutheria C9orf142 HGNC:27849 chromosome 9 open reading frame 142 Q9BUH6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 34 0 cytoplasm. nucleus multiple Amniota Deuterostomia Euteleostomi C9orf152 HGNC:31455 chromosome 9 open reading frame 152 Q5JTZ5 nucleus 54 0 nucleus nucleus Euarchontoglires Amniota Amniota C9orf153 HGNC:31456 chromosome 9 open reading frame 153 Q5TBE3 nucleus 32 0 nucleus nucleus Eutheria Eutheria Eutheria C9orf156 HGNC:30967 chromosome 9 open reading frame 156 Q9BU70 cytoplasm 37 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms C9orf16 HGNC:17823 chromosome 9 open reading frame 16 Q9BUW7 nucleus 38 0 nucleus nucleus Amniota Deuterostomia Bilateria C9orf163 HGNC:26718 chromosome 9 open reading frame 163 Q8N9P6 secreted 51 0 secreted secreted Homininae Homininae Eutheria C9orf169 HGNC:30529 chromosome 9 open reading frame 169 A8MQ03 secreted 56 0 secreted secreted Theria Theria Mammalia C9orf170 HGNC:33817 chromosome 9 open reading frame 170 A2RU37 secreted 81 0 secreted secreted Homininae Homininae Homo C9orf171 HGNC:33776 chromosome 9 open reading frame 171 Q6ZQR2 mitochondrion 33 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota C9orf172 HGNC:37284 chromosome 9 open reading frame 172 C9J069 secreted 12 0 secreted secreted NA NA Eumetazoa C9orf173 HGNC:37285 chromosome 9 open reading frame 173 Q8N7X2 nucleus 68 0 nucleus nucleus Theria Chordata Eumetazoa C9orf24 HGNC:19919 chromosome 9 open reading frame 24 Q8NCR6 Cytoplasm, cytoskeleton (By similarity). Nucleus. Cytoplasm. Note=Localizes to the manchette in elongating spermatids (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines. Nucleus (GO:0005634); Perinuclear region (GO:0048471) 15242845,15242845 secreted 37 0 cytoplasm. nucleus multiple Amniota Amniota Amniota C9orf3 HGNC:1361 chromosome 9 open reading frame 3 Q8N6M6 Cytoplasm (Potential). secreted 13 0 secreted secreted Tetrapoda Deuterostomia Cell.Organisms C9orf37 HGNC:23395 chromosome 9 open reading frame 37 Q9H2J1 endoplasmic reticulum membrane 54 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Homininae Opisthokonta C9orf38 HGNC:23398 chromosome 9 open reading frame 38 Q9UI66 secreted 13 0 secreted secreted NA NA Eutheria C9orf40 HGNC:23433 chromosome 9 open reading frame 40 Q8IXQ3 Cytoplasm (GO:0005737) 17081983 nucleus 60 0 cytoplasm cytoplasm Amniota Amniota Amniota C9orf41 HGNC:23435 chromosome 9 open reading frame 41 Q8N4J0 nucleus 41 0 nucleus nucleus Eukaryota Eukaryota Eukaryota C9orf43 HGNC:23570 chromosome 9 open reading frame 43 Q8TAL5 nucleus 86 0 nucleus nucleus Eutheria Eutheria Eutheria C9orf47 HGNC:23669 chromosome 9 open reading frame 47 Q6ZRZ4 Secreted (Potential). secreted 12 0 secreted secreted Homininae Homininae Primates C9orf50 HGNC:23677 chromosome 9 open reading frame 50 Q5SZB4 nucleus 77 0 nucleus nucleus Eutheria Eutheria Eutheria C9orf57 HGNC:27037 chromosome 9 open reading frame 57 Q5W0N0 Membrane; Single-pass membrane protein (Potential). secreted 69 1 secreted secreted Homininae Euarchontoglires Boreoeutheria C9orf62 HGNC:28581 chromosome 9 open reading frame 62 Q8N4C0 secreted 52 0 secreted secreted Homininae Homininae Boreoeutheria C9orf64 HGNC:28144 chromosome 9 open reading frame 64 Q5T6V5 cytoplasm 18 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms C9orf66 HGNC:26436 chromosome 9 open reading frame 66 Q5T8R8 secreted 39 0 secreted secreted Human Human Euarchontoglires C9orf69 HGNC:31009 chromosome 9 open reading frame 69 H0YL14 Membrane; Multi-pass membrane protein (Potential). Nucleus. Cytoplasm. Note=Upon HHV-1 infection, accumulates arround the nuclear membrane and translocates into the nucleus. endoplasmic reticulum membrane 28 2 cytoplasm. nucleus multiple NA NA Bilateria C9orf72 HGNC:28337 chromosome 9 open reading frame 72 Q96LT7 Cytoplasm. Nucleus. Note=Detected in the cytoplasm of neurons from post mortem brain tissue (PubMed:21944778). Detected in the nucleus in fibroblasts (PubMed:21944779). cytoplasm 1 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota C9orf78 HGNC:24932 chromosome 9 open reading frame 78 Q9NZ63 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 95 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota C9orf84 HGNC:26535 chromosome 9 open reading frame 84 Q5VXU9 nucleus 84 0 nucleus nucleus Theria Theria Eumetazoa C9orf85 HGNC:28784 chromosome 9 open reading frame 85 Q96MD7 cytoplasm 62 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota C9orf89 HGNC:28148 chromosome 9 open reading frame 89 Q96LW7 Nucleus. Note=Co-expression with BCL10 induced translocation from nucleus to cytosol. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15637807,15637807 nucleus 29 0 cytoplasm. nucleus multiple Amniota Euteleostomi Euteleostomi C9orf9 HGNC:1367 chromosome 9 open reading frame 9 Q96E40 nucleus 55 0 nucleus nucleus Deuterostomia Deuterostomia Deuterostomia C9orf91 HGNC:24513 chromosome 9 open reading frame 91 Q5VZI3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 43 2 n/a n/a Tetrapoda Tetrapoda Euteleostomi C9orf92 HGNC:19054 chromosome 9 open reading frame 92 A6NGG3 secreted 45 0 secreted secreted Homininae Homininae Eutheria C9orf96 HGNC:28669 chromosome 9 open reading frame 96 Q8NE28 nucleus 6 0 nucleus nucleus Deuterostomia Deuterostomia NA CA1 HGNC:1368 carbonic anhydrase I P00915 Cytoplasm. Cytoplasm (GO:0005737) 11680594 cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms CA10 HGNC:1369 carbonic anhydrase X Q9NS85 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12044474,17081983 cytoplasm 19 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CA11 HGNC:1370 carbonic anhydrase XI O75493 Secreted (Potential). Extracellular (GO:0005576) 9878252 cytoplasm 18 0 secreted secreted Theria Theria Cell.Organisms CA12 HGNC:1371 carbonic anhydrase XII O43570 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9636197,11101628,12923247 secreted 28 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CA13 HGNC:14914 carbonic anhydrase XIII Q8N1Q1 Cytoplasm (GO:0005737) 14600151 cytoplasm 52 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms CA14 HGNC:1372 carbonic anhydrase XIV Q9ULX7 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10512682,11172051 secreted 27 1 plasma membrane plasma membrane Theria Eukaryota Cell.Organisms CA2 HGNC:1373 carbonic anhydrase II P00918 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Extracellular (GO:0005576) 2117271,11457932,11457932,10821857,14718574 cytoplasm 76 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Bilateria Cell.Organisms Cell.Organisms CA3 HGNC:1374 carbonic anhydrase III, muscle specific P07451 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9890711,7574487,1764784,1361281 cytoplasm 100 0 cytoplasm. secreted multiple Amniota Amniota Cell.Organisms CA4 HGNC:1375 carbonic anhydrase IV P22748 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Sarcoplasmic reticulum (GO:0016529) 1311094,2111324,8903383,8675662,9632745 secreted 19 1 endoplasmic reticulum. plasma membrane multiple Euteleostomi Eukaryota Cell.Organisms CA5A HGNC:1377 carbonic anhydrase VA, mitochondrial P35218 Mitochondrion. Mitochondrion (GO:0005739) 8356065 mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Eukaryota Cell.Organisms CA5B HGNC:1378 carbonic anhydrase VB, mitochondrial Q9Y2D0 Mitochondrion. Mitochondrion (GO:0005739) 10409679 mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Eukaryota Cell.Organisms CA6 HGNC:1380 carbonic anhydrase VI P23280 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11303978,10523402,8429198,10705347 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Euteleostomi Cell.Organisms CA7 HGNC:1381 carbonic anhydrase VII P43166 Cytoplasm (Probable). Cytoplasm (GO:0005737) 11875253 cytoplasm 48 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms CA8 HGNC:1382 carbonic anhydrase VIII P35219 Cytoplasm (GO:0005737) 12611586 cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms CA9 HGNC:1383 carbonic anhydrase IX Q16790 Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8084592,11676494,8661007,11705854,14567991 secreted 30 1 cytoplasm. nucleus. plasma membrane multiple Theria Eukaryota Cell.Organisms CAAP1 HGNC:25834 caspase activity and apoptosis inhibitor 1 Q9H8G2 Nucleus (GO:0005634) 17081983 nucleus 93 0 nucleus nucleus Tetrapoda Euteleostomi Olfactores CAB39 HGNC:20292 calcium binding protein 39 Q9Y376 Cytoplasm (Potential). cytoplasm 52 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota CAB39L HGNC:20290 calcium binding protein 39-like Q9H9S4 cytoplasm 48 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota CABIN1 HGNC:24187 calcineurin binding protein 1 Q9Y6J0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9655484,14623296,14623296 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms CABLES1 HGNC:25097 Cdk5 and Abl enzyme substrate 1 Q8TDN4 Nucleus (By similarity). Cytoplasm (By similarity). Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Mitochondrion (GO:0005739) 11585773,14729625,12612882,11527406,11585773,11527406,11585773,11527406 nucleus 67 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota CABLES2 HGNC:16143 Cdk5 and Abl enzyme substrate 2 Q9BTV7 secreted 32 2 n/a n/a Deuterostomia Eukaryota Eukaryota CABP1 HGNC:1384 calcium binding protein 1 Q9NZU7 Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Isoform L-CaBP1: Cytoplasm, cytoskeleton. Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor (Probable). Note=S-CaBP1 is localized at or near the plasma membrane. Endoplasmic reticulum (GO:0005783); Cytoskeleton (GO:0005856); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Microsome (GO:0005792) 12032348,11415439,7876340,1316906,14570872,10625670,14570872,10625670,14570872,1316906 cytoplasm 89 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Euteleostomi Euteleostomi Cell.Organisms CABP2 HGNC:1385 calcium binding protein 2 Q9NPB3 Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Endoplasmic reticulum (GO:0005783) 11415439 cytoplasm 60 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Theria Theria Cell.Organisms CABP4 HGNC:1386 calcium binding protein 4 P57796 Cytoplasm. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors (By similarity). Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 1316906,1316906 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Theria Euteleostomi Cell.Organisms CABP5 HGNC:13714 calcium binding protein 5 Q9NP86 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CABP7 HGNC:20834 calcium binding protein 7 Q86V35 Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein (Probable). Integral to membrane (GO:0016021) cytoplasm 22 1 cytoplasm. golgi apparatus membrane. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms CABS1 HGNC:30710 calcium-binding protein, spermatid-specific 1 Q96KC9 Cytoplasm (By similarity). Mitochondrion (By similarity). Cell projection, cilium, flagellum (By similarity). Note=Detected in mitochondria of step 17 to 18 spermatids. Associated with the mitochondrial inner membrane in step 18 spermatids (By similarity). secreted 53 0 secreted secreted Eutheria Eutheria Eutheria CABYR HGNC:15569 calcium binding tyrosine-(Y)-phosphorylation regulated O75952 Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Isoform 1: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Isoform 3: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Isoform 5: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic. Cytoplasm (GO:0005737); Cell projection (GO:0042995) 11820818,11820818 nucleus 41 0 cytoplasm. nucleus multiple Theria Theria Deuterostomia CACFD1 HGNC:1365 calcium channel flower domain containing 1 Q9UGQ2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 15 3 plasma membrane plasma membrane Bilateria Bilateria NA CACHD1 HGNC:29314 cache domain containing 1 Q5VU97 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 59 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms CACNA1A HGNC:1388 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit O00555 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) nucleus 19 22 nucleus nucleus Bilateria Eukaryota Cell.Organisms CACNA1B HGNC:1389 calcium channel, voltage-dependent, N type, alpha 1B subunit Q00975 Membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8750830,11353727,17081983 cytoplasm 24 22 cytoplasm. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms CACNA1C HGNC:1390 calcium channel, voltage-dependent, L type, alpha 1C subunit Q13936 Membrane; Multi-pass membrane protein. Cell membrane (By similarity). Note=The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane (By similarity). Plasma membrane (GO:0005886) 8392192,7959794 plasma membrane 13 27 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms CACNA1D HGNC:1391 calcium channel, voltage-dependent, L type, alpha 1D subunit Q01668 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10468580,17081983 plasma membrane 11 25 nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms CACNA1E HGNC:1392 calcium channel, voltage-dependent, R type, alpha 1E subunit Q15878 Membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 9799129 vacuole membrane 9 24 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms CACNA1F HGNC:1393 calcium channel, voltage-dependent, L type, alpha 1F subunit O60840 Membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 12111638 plasma membrane 18 22 nucleus nucleus Bilateria Eukaryota NA CACNA1G HGNC:1394 calcium channel, voltage-dependent, T type, alpha 1G subunit O43497 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) secreted 17 25 n/a n/a Bilateria Eukaryota Cell.Organisms CACNA1H HGNC:1395 calcium channel, voltage-dependent, T type, alpha 1H subunit O95180 Membrane; Multi-pass membrane protein. Nucleus (GO:0005634);Integral to membrane (GO:0016021) 17081983/9670923 plasma membrane 14 25 nucleus nucleus Bilateria Eukaryota Cell.Organisms CACNA1I HGNC:1396 calcium channel, voltage-dependent, T type, alpha 1I subunit Q9P0X4 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) cytoplasm 18 22 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CACNA1S HGNC:1397 calcium channel, voltage-dependent, L type, alpha 1S subunit Q13698 Membrane; Multi-pass membrane protein. Sarcoplasmic reticulum (GO:0016529) 9199552 plasma membrane 8 24 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms CACNA2D1 HGNC:1399 calcium channel, voltage-dependent, alpha 2/delta subunit 1 P54289 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10534405 secreted 11 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CACNA2D2 HGNC:1400 calcium channel, voltage-dependent, alpha 2/delta subunit 2 Q9NY47 Membrane; Single-pass type I membrane protein (Potential). Note=Colocalizes with CACNA1A in lipid raft fractions (By similarity). Plasma membrane (GO:0005886) 10766861,1309651,9738015 secreted 14 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CACNA2D3 HGNC:15460 calcium channel, voltage-dependent, alpha 2/delta subunit 3 Q8IZS8 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 18 1 secreted secreted Chordata Bilateria Cell.Organisms CACNA2D4 HGNC:20202 calcium channel, voltage-dependent, alpha 2/delta subunit 4 Q7Z3S7 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12181424 secreted 13 1 plasma membrane plasma membrane Chordata Bilateria Cell.Organisms CACNB1 HGNC:1401 calcium channel, voltage-dependent, beta 1 subunit Q02641 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886);Nucleus (GO:0005634) 10465427,10066897/17081983 nucleus 56 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa CACNB2 HGNC:1402 calcium channel, voltage-dependent, beta 2 subunit Q08289 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (By similarity). Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 12719232/12719232 nucleus 59 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa CACNB3 HGNC:1403 calcium channel, voltage-dependent, beta 3 subunit P54284 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8621722,12042350 nucleus 36 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa CACNB4 HGNC:1404 calcium channel, voltage-dependent, beta 4 subunit O00305 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9442082,16137684 nucleus 59 0 cytoplasm cytoplasm Euteleostomi Bilateria Holozoa CACNG1 HGNC:1405 calcium channel, voltage-dependent, gamma subunit 1 Q06432 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8387489 golgi apparatus membrane 34 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi CACNG2 HGNC:1406 calcium channel, voltage-dependent, gamma subunit 2 Q9Y698 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11170751,8387489 plasma membrane 52 4 plasma membrane plasma membrane Amniota Euteleostomi Bilateria CACNG3 HGNC:1407 calcium channel, voltage-dependent, gamma subunit 3 O60359 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8387489,11170751 plasma membrane 48 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Bilateria CACNG4 HGNC:1408 calcium channel, voltage-dependent, gamma subunit 4 Q9UBN1 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10613843,8387489,11170751 plasma membrane 98 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria CACNG5 HGNC:1409 calcium channel, voltage-dependent, gamma subunit 5 Q9UF02 Membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Plasma membrane (GO:0005886) 8387489,11170751 plasma membrane 18 3 plasma membrane plasma membrane Eutheria Euteleostomi Bilateria CACNG6 HGNC:13625 calcium channel, voltage-dependent, gamma subunit 6 Q9BXT2 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 11170751 golgi apparatus membrane 31 4 plasma membrane plasma membrane Eutheria Euteleostomi Euteleostomi CACNG7 HGNC:13626 calcium channel, voltage-dependent, gamma subunit 7 P62955 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 8387489,11170751 plasma membrane 19 3 plasma membrane plasma membrane Theria Euteleostomi Bilateria CACNG8 HGNC:13628 calcium channel, voltage-dependent, gamma subunit 8 Q8WXS5 Membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Plasma membrane (GO:0005886) 8387489,11170751 plasma membrane 56 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria CACTIN HGNC:29938 cactin, spliceosome C complex subunit Q8WUQ7 Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. Nucleus (GO:0005634) 10508479 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CACUL1 HGNC:23727 CDK2-associated, cullin domain 1 Q86Y37 nucleus 65 1 nucleus nucleus Deuterostomia Deuterostomia Eukaryota CACYBP HGNC:30423 calcyclin binding protein Q9HB71 Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12895292,11927578,12895292,11927578 cytoplasm 51 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota CAD HGNC:1424 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase P27708 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12438317,17081983,12438317,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms CADM1 HGNC:5951 cell adhesion molecule 1 Q9BY67 Cell membrane; Single-pass type I membrane protein. Cell junction, synapse (By similarity). Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11279526,11279526,12234973 plasma membrane 23 1 nucleus. plasma membrane multiple Tetrapoda Euteleostomi Metazoa CADM2 HGNC:29849 cell adhesion molecule 2 Q8N3J6 Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons. plasma membrane 15 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa CADM3 HGNC:17601 cell adhesion molecule 3 Q8N126 Cell junction (By similarity). Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized at the cell-cell attached sites of the plasma membrane (By similarity). Plasma membrane (GO:0005886) 14659875 plasma membrane 24 1 plasma membrane plasma membrane Theria Chordata Metazoa CADM4 HGNC:30825 cell adhesion molecule 4 Q8NFZ8 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 11536053 endoplasmic reticulum membrane 14 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Euteleostomi Metazoa CADPS HGNC:1426 Ca++-dependent secretion activator Q9ULU8 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse (By similarity). Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 1516133,9697858,9525942,9697858,9697858 nucleus 84 0 cytoplasm cytoplasm Deuterostomia Bilateria Metazoa CADPS2 HGNC:16018 Ca++-dependent secretion activator 2 Q86UW7 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Synaptic vesicle (GO:0008021); Synapse (GO:0045202) 14530279,12659812,14530279,12659812,14530279,14530279,14530279 nucleus 80 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa CAGE1 HGNC:21622 cancer antigen 1 Q8TC20 Nucleus (GO:0005634) 12531476 cytoplasm 12 0 nucleus nucleus Mammalia Mammalia Holozoa CALB1 HGNC:1434 calbindin 1, 28kDa P05937 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9373717,1537319,16763551,16763551 cytoplasm 19 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms CALB2 HGNC:1435 calbindin 2 P22676 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10942575,10942575 cytoplasm 26 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms CALCA HGNC:1437 calcitonin-related polypeptide alpha P01258 Secreted. Extracellular (GO:0005576) 12359227 secreted 100 0 secreted secreted Tetrapoda Euteleostomi NA CALCB HGNC:1438 calcitonin-related polypeptide beta P10092 Secreted. Extracellular (GO:0005576) 8468047 secreted 100 0 secreted secreted Eutheria Euteleostomi Craniata CALCOCO1 HGNC:29306 calcium binding and coiled-coil domain 1 Q9P1Z2 Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16931570,16931570 cytoplasm 9 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Metazoa CALCOCO2 HGNC:29912 calcium binding and coiled-coil domain 2 Q13137 Cytoplasm, perinuclear region. Golgi apparatus. Cytoplasm, cytoskeleton. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot- associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7540613,9230084,7540613,12869526,9230084 cytoplasm 16 0 cytoplasm. golgi apparatus. nucleus multiple Tetrapoda Tetrapoda Opisthokonta CALCR HGNC:1440 calcitonin receptor P30988 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Vesicle (None); Cell surface (GO:0009986) 1331173,12531889,12531889 plasma membrane 100 7 plasma membrane plasma membrane Theria Bilateria Holozoa CALCRL HGNC:16709 calcitonin receptor-like Q16602 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endosome (GO:0005768); Cell surface (GO:0009986) 12630808,12574158,9620797,2826160,12684503,12538603,12234182,12093471,12084528,12128288,10882736,10882736,16293613 plasma membrane 100 7 endosome. lysosome. plasma membrane multiple Euteleostomi Bilateria Holozoa CALD1 HGNC:1441 caldesmon 1 Q05682 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril (By similarity). Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10766836,8581978/17081983,17081983 cytoplasm 82 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Olfactores CALHM1 HGNC:23494 calcium homeostasis modulator 1 Q8IU99 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 34 4 endoplasmic reticulum membrane. plasma membrane multiple Amniota Euteleostomi Craniata CALHM2 HGNC:23493 calcium homeostasis modulator 2 Q9HA72 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 44 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Bilateria Eumetazoa CALHM3 HGNC:23458 calcium homeostasis modulator 3 Q86XJ0 Membrane; Multi-pass membrane protein (Potential). plasma membrane 23 4 plasma membrane plasma membrane Amniota Amniota Olfactores CALM1 HGNC:1442 calmodulin 1 (phosphorylase kinase, delta) P62158 Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9278050,10416864,10899953 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CALM2 HGNC:1445 calmodulin 2 (phosphorylase kinase, delta) P62158 Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9278050,10416864,11591728 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CALM3 HGNC:1449 calmodulin 3 (phosphorylase kinase, delta) P62158 Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9278050,10416864,11591728 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CALML3 HGNC:1452 calmodulin-like 3 P27482 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11278607,11278607,11278607 cytoplasm 81 0 cytoplasm. nucleus multiple Homininae Cell.Organisms Cell.Organisms CALML4 HGNC:18445 calmodulin-like 4 Q96GE6 cytoplasm 31 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CALML5 HGNC:18180 calmodulin-like 5 Q9NZT1 Extracellular (GO:0005576) 16188874 cytoplasm 38 0 secreted secreted Eutheria Eutheria Cell.Organisms CALML6 HGNC:24193 calmodulin-like 6 Q8TD86 Cytoplasm. Nucleus. cytoplasm 31 0 cytoplasm. nucleus multiple Catarrhini Chordata Cell.Organisms CALN1 HGNC:13248 calneuron 1 Q9BXU9 Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein (Probable). Integral to membrane (GO:0016021) cytoplasm 20 1 cytoplasm. golgi apparatus membrane. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms CALR HGNC:1455 calreticulin P27797 Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen (By similarity). Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Sarcoplasmic reticulum (GO:0016529); Mitochondrion (GO:0005739); Endoplasmic reticulum lumen (GO:0005788) 1939344,15671042,1939344,7923996,8062452,8062452,7622522,12324449,15598749,17215244 endoplasmic reticulum 93 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Cell.Organisms CALR3 HGNC:20407 calreticulin 3 Q96L12 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783); Sarcoplasmic reticulum (GO:0016529) 12384296,12384296 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Mammalia Mammalia NA CALU HGNC:1458 calumenin O43852 Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 10222138,10222138,10222138,15598749,17081983 endoplasmic reticulum 55 0 endoplasmic reticulum. golgi apparatus. melanosome. mitochondrion. nucleus. secreted multiple Bilateria Eukaryota Eukaryota CALY HGNC:17938 calcyon neuron-specific vesicular protein Q9NYX4 Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Dendrite (GO:0030425) 14534309,10698743,14534309,10698743,14534309,14534309,10698743 cytoplasm 21 1 cytoplasm. endoplasmic reticulum. golgi apparatus. plasma membrane multiple Eutheria Eutheria Craniata CAMK1 HGNC:1459 calcium/calmodulin-dependent protein kinase I Q14012 Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity). Cytoplasm (GO:0005737) nucleus 57 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms CAMK1D HGNC:19341 calcium/calmodulin-dependent protein kinase ID Q8IU85 Cytoplasm (Probable). Nucleus (Probable). Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11050006,11050006 nucleus 55 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CAMK1G HGNC:14585 calcium/calmodulin-dependent protein kinase IG Q96NX5 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 12637513,12637513 nucleus 46 0 golgi apparatus golgi apparatus Euteleostomi Cell.Organisms Cell.Organisms CAMK2A HGNC:1460 calcium/calmodulin-dependent protein kinase II alpha Q9UQM7 Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity). Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2164678,2164678,2164678 cytoplasm 60 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CAMK2B HGNC:1461 calcium/calmodulin-dependent protein kinase II beta Q13554 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR. Cytoplasm (GO:0005737) 9060999,10858498 cytoplasm 41 1 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CAMK2D HGNC:1462 calcium/calmodulin-dependent protein kinase II delta Q13557 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (Probable). Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10852918,10525155,10852918,17081983 cytoplasm 63 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CAMK2G HGNC:1463 calcium/calmodulin-dependent protein kinase II gamma Q13555 Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12554746,11535587,11080189,17081983,12554746 cytoplasm 65 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CAMK2N1 HGNC:24190 calcium/calmodulin-dependent protein kinase II inhibitor 1 Q7Z7J9 Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). secreted 25 0 secreted secreted Euarchontoglires Eutheria Craniata CAMK2N2 HGNC:24197 calcium/calmodulin-dependent protein kinase II inhibitor 2 Q96S95 Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2 (By similarity). secreted 23 0 cytoplasm. nucleus multiple Human Human Craniata CAMK4 HGNC:1464 calcium/calmodulin-dependent protein kinase IV Q16566 Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2011593,2011593 nucleus 30 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CAMKK1 HGNC:1469 calcium/calmodulin-dependent protein kinase kinase 1, alpha Q8N5S9 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 10560916 cytoplasm 20 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CAMKK2 HGNC:1470 calcium/calmodulin-dependent protein kinase kinase 2, beta Q96RR4 Nucleus (By similarity). Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. Cytoplasm (GO:0005737) 11395482 cytoplasm 26 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CAMKMT HGNC:26276 calmodulin-lysine N-methyltransferase Q7Z624 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Golgi apparatus. cytoplasm 9 0 cytoplasm. golgi apparatus. nucleus multiple Chordata Eukaryota Cell.Organisms CAMKV HGNC:28788 CaM kinase-like vesicle-associated Q8NCB2 Cell membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity). Integral to membrane (GO:0016021); Synaptic vesicle (GO:0008021) 8283228,8283228 nucleus 26 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms CAMLG HGNC:1471 calcium modulating ligand P49069 Membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Lysosome (GO:0005764) 11006089,7522304,11006089,9632697,9632697,9632697 nucleus 53 3 cytoplasm. endoplasmic reticulum. golgi apparatus. lysosome. nucleus multiple Euteleostomi Euteleostomi Craniata CAMP HGNC:1472 cathelicidin antimicrobial peptide P49913 Secreted. Secretory granule (GO:0030141); Extracellular (GO:0005576) 11389039,11389039 secreted 100 0 secreted secreted Amniota Amniota Amniota CAMSAP1 HGNC:19946 calmodulin regulated spectrin-associated protein 1 Q5T5Y3 Cytoplasm, cytoskeleton (Potential). nucleus 16 0 nucleus nucleus Euteleostomi Bilateria Eukaryota CAMSAP2 HGNC:29188 calmodulin regulated spectrin-associated protein family, member 2 Q08AD1 Cytoplasm, cytoskeleton (Potential). secreted 33 0 secreted secreted Euteleostomi Bilateria Eukaryota CAMSAP3 HGNC:29307 calmodulin regulated spectrin-associated protein family, member 3 Q9P1Y5 Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton (Potential). Note=Scattered in the cytoplasm. Localizes along zonula adherens only at mature cell- cell contacts. nucleus 13 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota CAMTA1 HGNC:18806 calmodulin binding transcription activator 1 Q9Y6Y1 Nucleus (Probable). Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12964007,15138581,17081983 nucleus 30 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota CAMTA2 HGNC:18807 calmodulin binding transcription activator 2 O94983 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16678093,16678093 nucleus 30 1 cytoplasm. nucleus multiple Theria Bilateria Eukaryota CAND1 HGNC:30688 cullin-associated and neddylation-dissociated 1 Q86VP6 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 10581176,15598749 nucleus 51 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Eukaryota CAND2 HGNC:30689 cullin-associated and neddylation-dissociated 2 (putative) O75155 Nucleus (By similarity). Intracellular vesicle (None) 12692129 nucleus 89 0 nucleus nucleus Bilateria Eukaryota Eukaryota CANT1 HGNC:19721 calcium activated nucleotidase 1 Q8WVQ1 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Processed form: Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12234496,12167635,12167635,12167635 cytoplasm 27 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. plasma membrane. secreted multiple Bilateria Eukaryota Eukaryota CANX HGNC:1473 calnexin P27824 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER. Endoplasmic reticulum (GO:0005783); Nuclear membrane (GO:0005635); Endoplasmic reticulum membrane (GO:0005789); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Mitochondrion (GO:0005739) 8136357,12383251,12805210,9024687,12610305,9717723,11506858,17215244,15561729,8278814,12805210,12052826,10461883,1326756,8549676,11350933,9050874,8278814,8278814,8278814,15598749 endoplasmic reticulum membrane 50 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. lysosome. melanosome. mitochondrion. nucleus membrane. plasma membrane multiple Opisthokonta Eukaryota Cell.Organisms CAP1 HGNC:20040 CAP, adenylate cyclase-associated protein 1 (yeast) Q01518 Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11950878,17081983,17081983 cytoplasm 21 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CAP2 HGNC:20039 CAP, adenylate cyclase-associated protein, 2 (yeast) P40123 Cell membrane; Peripheral membrane protein (By similarity). cytoplasm 24 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CAPG HGNC:1474 capping protein (actin filament), gelsolin-like P40121 Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12637565,12637565 cytoplasm 38 0 cytoplasm. melanosome. nucleus multiple Euteleostomi Euteleostomi Eukaryota CAPN1 HGNC:1476 calpain 1, (mu/I) large subunit P07384 Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 1656060,12591934,1656060,12591934 cytoplasm 44 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CAPN10 HGNC:1477 calpain 10 Q9HC96 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11375982,11375982,11375982 cytoplasm 18 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms CAPN11 HGNC:1478 calpain 11 Q9UMQ6 Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Cytoplasm (GO:0005737) 10340998 cytoplasm 40 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CAPN12 HGNC:13249 calpain 12 Q6ZSI9 cytoplasm 30 0 cytoplasm cytoplasm Theria Theria Cell.Organisms CAPN13 HGNC:16663 calpain 13 Q6MZZ7 Cytoplasm (GO:0005737) cytoplasm 18 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms CAPN14 HGNC:16664 calpain 14 A8MX76 cytoplasm 27 0 cytoplasm cytoplasm Amniota Amniota Cell.Organisms CAPN15 HGNC:11182 calpain 15 O75808 Nucleus (GO:0005634) cytoplasm 20 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CAPN2 HGNC:1479 calpain 2, (m/II) large subunit P17655 Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Membrane fraction (GO:0005624) ,9873017,,9873017 cytoplasm 41 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CAPN3 HGNC:1480 calpain 3, (p94) P20807 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10229226,11485017 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CAPN5 HGNC:1482 calpain 5 O15484 Cytoplasm (GO:0005737) 11517927 cytoplasm 34 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA CAPN6 HGNC:1483 calpain 6 Q9Y6Q1 Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle. Cytoplasm (GO:0005737) 10340998 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms CAPN7 HGNC:1484 calpain 7 Q9Y6W3 Nucleus. Nucleus (GO:0005634) 11342116 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms CAPN8 HGNC:1485 calpain 8 A6NHC0 Cytoplasm (By similarity). Golgi apparatus (By similarity). cytoplasm 41 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CAPN9 HGNC:1486 calpain 9 O14815 Nucleus (GO:0005634) 9917325 cytoplasm 46 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms CAPNS1 HGNC:1481 calpain, small subunit 1 P04632 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates to the plasma membrane upon calcium binding (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 1656060,12591934,12358155,1656060,12591934,12591934 cytoplasm 44 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota CAPNS2 HGNC:16371 calpain, small subunit 2 Q96L46 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates to the plasma membrane upon calcium binding (By similarity). Cytoplasm (GO:0005737) 11853546 cytoplasm 40 0 cytoplasm cytoplasm NA NA Eukaryota CAPRIN1 HGNC:6743 cell cycle associated protein 1 Q14444 Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules (By similarity). Plasma membrane (GO:0005886) 7657653 nucleus 67 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Metazoa CAPRIN2 HGNC:21259 caprin family member 2 Q6IMN6 Isoform 1: Cytoplasm. Isoform 2: Mitochondrion. Cytoplasm. Isoform 5: Mitochondrion. Note=Colocalizes with aggregated mitochondria. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 14593112/14593112,14593112 secreted 25 1 cytoplasm. mitochondrion multiple Tetrapoda Euteleostomi Metazoa CAPS HGNC:1487 calcyphosine Q13938 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms CAPS2 HGNC:16471 calcyphosine 2 Q9BXY5 Cytoplasm (GO:0005737) 14530279 nucleus 20 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota CAPSL HGNC:28375 calcyphosine-like Q8WWF8 Cytoplasm (Potential). cytoplasm 43 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms CAPZA1 HGNC:1488 capping protein (actin filament) muscle Z-line, alpha 1 P52907 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) 9354614 cytoplasm 96 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota CAPZA2 HGNC:1490 capping protein (actin filament) muscle Z-line, alpha 2 P47755 Cytoskeleton (GO:0005856) 7665558 cytoplasm 94 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota CAPZA3 HGNC:24205 capping protein (actin filament) muscle Z-line, alpha 3 Q96KX2 Cytoskeleton (GO:0005856) 12029070 cytoplasm 24 0 cytoplasm cytoplasm Human Human Eukaryota CAPZB HGNC:1491 capping protein (actin filament) muscle Z-line, beta P47756 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere (By similarity). Cytoskeleton (GO:0005856); Mitochondrion (GO:0005739) 7665558,15598749 cytoplasm 91 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota CARD10 HGNC:16422 caspase recruitment domain family, member 10 Q9BWT7 Cytoplasm (By similarity). Plasma membrane (GO:0005886) 11259443 cytoplasm 24 0 cytoplasm cytoplasm Amniota Amniota Eumetazoa CARD11 HGNC:16393 caspase recruitment domain family, member 11 Q9BXL7 Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11278692,17363905,11356195 cytoplasm 29 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CARD14 HGNC:16446 caspase recruitment domain family, member 14 Q9BXL6 Isoform 1: Cytoplasm. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11278692,11278692 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa CARD16 HGNC:33701 caspase recruitment domain family, member 16 Q5EG05 cytoplasm 88 0 cytoplasm cytoplasm Catarrhini Mammalia Euteleostomi CARD17 HGNC:33827 caspase recruitment domain family, member 17 Q5XLA6 Cytoplasm (By similarity). cytoplasm 76 0 cytoplasm cytoplasm NA NA Euteleostomi CARD18 HGNC:28861 caspase recruitment domain family, member 18 P57730 cytoplasm 54 0 cytoplasm cytoplasm NA NA Euteleostomi CARD6 HGNC:16394 caspase recruitment domain family, member 6 Q9BX69 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12775719,12775719,17081983 secreted 15 0 cytoplasm. nucleus multiple Theria Theria Cell.Organisms CARD8 HGNC:17057 caspase recruitment domain family, member 8 Q9Y2G2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11551959,15030775,11551959 cytoplasm 21 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Chordata CARD9 HGNC:16391 caspase recruitment domain family, member 9 Q9H257 Cytoplasm. Cytoplasm (GO:0005737) 11053425 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Holozoa CARF HGNC:14435 calcium responsive transcription factor Q8N187 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11832226,11832226 nucleus 74 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eumetazoa CARHSP1 HGNC:17150 calcium regulated heat stable protein 1, 24kDa Q9Y2V2 Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Detected at cytoplasmic stress granules and P- bodies. Detected at exosome granules where mRNA is degraded (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9712905,12801884,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms CARKD HGNC:25576 carbohydrate kinase domain containing Q8IW45 Mitochondrion (By similarity). mitochondrion 77 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms CARM1 HGNC:23393 coactivator-associated arginine methyltransferase 1 Q86X55 Nucleus. Cytoplasm. Note=Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane. Nucleus (GO:0005634) nucleus 23 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms CARNS1 HGNC:29268 carnosine synthase 1 A5YM72 cytoplasm 63 1 cytoplasm cytoplasm Mammalia Cell.Organisms Cell.Organisms CARS HGNC:1493 cysteinyl-tRNA synthetase P49589 Cytoplasm. Cytoplasm (GO:0005737) 11347887 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CARS2 HGNC:25695 cysteinyl-tRNA synthetase 2, mitochondrial (putative) Q9HA77 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739); Cytosol (GO:0005829) 15779907,15779907 cytoplasm 26 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms CARTPT HGNC:24323 CART prepropeptide Q16568 Secreted (Potential). Extracellular (GO:0005576) 11711504 secreted 99 0 secreted secreted Theria Euteleostomi Euteleostomi CASC1 HGNC:29599 cancer susceptibility candidate 1 Q6TDU7 Cytoplasm (GO:0005737) 14583591 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CASC10 HGNC:31448 cancer susceptibility candidate 10 Q5T4H9 secreted 64 0 secreted secreted Homininae Homininae Eutheria CASC3 HGNC:17040 cancer susceptibility candidate 3 O15234 Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Note=Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress. Cytoplasm (GO:0005737); Nucleus (GO:0005634) , nucleus 20 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa CASC4 HGNC:24892 cancer susceptibility candidate 4 Q6P4E1 Membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 17 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Euteleostomi Chordata CASC5 HGNC:24054 cancer susceptibility candidate 5 Q8NG31 Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle. Kinetochore (GO:0000776); Nucleus (GO:0005634) 15824131,15561729,10980622,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Deuterostomia CASD1 HGNC:16014 CAS1 domain containing 1 Q96PB1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11703667 endoplasmic reticulum membrane 55 14 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota CASK HGNC:1497 calcium/calmodulin-dependent serine protein kinase (MAGUK family) O14936 Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10993877,10749215,10749215 cytoplasm 27 1 cytoplasm. nucleus. plasma membrane multiple Chordata Bilateria Cell.Organisms CASKIN1 HGNC:20879 CASK interacting protein 1 Q8WXD9 Cytoplasm (By similarity). Cytoplasmic vesicle (GO:0016023) 12040031 cytoplasm 88 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms CASKIN2 HGNC:18200 CASK interacting protein 2 Q8WXE0 Cytoplasm (By similarity). cytoplasm 42 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms CASP1 HGNC:1499 caspase 1, apoptosis-related cysteine peptidase P29466 Cytoplasm. Cytoplasm (GO:0005737) 11997061,7876192 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CASP10 HGNC:1500 caspase 10, apoptosis-related cysteine peptidase Q92851 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10187817,9153302 cytoplasm 24 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa CASP12 HGNC:19004 caspase 12 (gene/pseudogene) Q6UXS9 cytoplasm 45 0 cytoplasm cytoplasm Euarchontoglires Eutheria Metazoa CASP14 HGNC:1502 caspase 14, apoptosis-related cysteine peptidase P31944 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 12200134,11175259,16188874 cytoplasm 20 0 cytoplasm. nucleus. secreted multiple Mammalia Mammalia Metazoa CASP16 HGNC:27290 caspase 16, apoptosis-related cysteine peptidase (putative) P0CB46 cytoplasm 21 0 cytoplasm cytoplasm NA NA Metazoa CASP2 HGNC:1503 caspase 2, apoptosis-related cysteine peptidase P42575 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 12011445,16652156,12011445,12107826,12011445 cytoplasm 15 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Chordata Chordata Metazoa CASP3 HGNC:1504 caspase 3, apoptosis-related cysteine peptidase P42574 Cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9708895,11448953,17167422,17167422 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Bilateria Metazoa CASP4 HGNC:1505 caspase 4, apoptosis-related cysteine peptidase P49662 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 7797510,15123740,15123740 cytoplasm 57 0 cytoplasm. endoplasmic reticulum. mitochondrion multiple Euteleostomi Euteleostomi Metazoa CASP5 HGNC:1506 caspase 5, apoptosis-related cysteine peptidase P51878 cytoplasm 50 0 cytoplasm cytoplasm Catarrhini Eutheria Cell.Organisms CASP6 HGNC:1507 caspase 6, apoptosis-related cysteine peptidase P55212 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11262188,17167422,11262188 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa CASP7 HGNC:1508 caspase 7, apoptosis-related cysteine peptidase P55210 Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11448953,11448953,11829465 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Human Bilateria Cell.Organisms CASP8 HGNC:1509 caspase 8, apoptosis-related cysteine peptidase Q14790 Cytoplasm. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Nucleolus (GO:0005730); Membrane fraction (GO:0005624); Early endosome (GO:0005769); Cytoplasm (GO:0005737);Cytosol (GO:0005829) 10891503,12527898,17290218,11917123,16498403,12232792,11102441,12527898,17159907,17290218,11448953,17167422/11917123 cytoplasm 100 0 cytoplasm. endosome. mitochondrion. nucleus multiple Deuterostomia Deuterostomia Metazoa CASP8AP2 HGNC:1510 caspase 8 associated protein 2 Q9UKL3 Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12477726,17245429,12477726,17245429,17245429 nucleus 94 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi NA CASP9 HGNC:1511 caspase 9, apoptosis-related cysteine peptidase P55211 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11803376,12782307,11448953,17167422,11803376 cytoplasm 24 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Metazoa CASQ1 HGNC:1512 calsequestrin 1 (fast-twitch, skeletal muscle) P31415 Sarcoplasmic reticulum lumen. Mitochondrion. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294. Mitochondrion (GO:0005739); Sarcoplasmic reticulum (GO:0016529) 7945294,7945294 endoplasmic reticulum 94 0 endoplasmic reticulum. mitochondrion multiple Euteleostomi Bilateria Eukaryota CASQ2 HGNC:1513 calsequestrin 2 (cardiac muscle) O14958 Sarcoplasmic reticulum lumen. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. Sarcoplasmic reticulum (GO:0016529); Plasma membrane (GO:0005886) 9795116, endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Chordata Chordata Eukaryota CASR HGNC:1514 calcium-sensing receptor P41180 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7759551 plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Deuterostomia Cell.Organisms CASS4 HGNC:15878 Cas scaffolding protein family member 4 Q9NQ75 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CAST HGNC:1515 calpastatin P20810 Perinuclear region (GO:0048471);Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634);Cytoplasm (GO:0005737) 10859257/17081983/12591934,12591934/10859257 nucleus 8 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Euteleostomi CASZ1 HGNC:26002 castor zinc finger 1 Q86V15 Nucleus. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 16322216,16322216 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta CAT HGNC:1516 catalase P04040 Peroxisome. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Peroxisome (GO:0005777) 9818873,11729237,10960480 peroxisome 100 0 cytoplasm. mitochondrion. peroxisome multiple Cell.Organisms Cell.Organisms Cell.Organisms CATIP HGNC:25062 ciliogenesis associated TTC17 interacting protein Q7Z7H3 cytoplasm 29 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Opisthokonta CATSPER1 HGNC:17116 cation channel, sperm associated 1 Q8NEC5 Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. Plasma membrane (GO:0005886) 11595941 vacuole membrane 10 7 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms CATSPER2 HGNC:18810 cation channel, sperm associated 2 Q96P56 Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity). Note=Specifically located in the principal piece of sperm tail. Integral to membrane (GO:0016021) vacuole membrane 10 7 vacuole membrane vacuole membrane Mammalia Deuterostomia Cell.Organisms CATSPER3 HGNC:20819 cation channel, sperm associated 3 Q86XQ3 Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. Integral to membrane (GO:0016021) plasma membrane 17 6 plasma membrane plasma membrane Theria Deuterostomia Cell.Organisms CATSPER4 HGNC:23220 cation channel, sperm associated 4 Q7RTX7 Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. Plasma membrane (GO:0005886) 12932298 vacuole membrane 6 7 plasma membrane plasma membrane Mammalia Mammalia Cell.Organisms CATSPERB HGNC:20500 catsper channel auxiliary subunit beta Q9H7T0 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 65 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Mammalia Eumetazoa CATSPERD HGNC:28598 catsper channel auxiliary subunit delta Q86XM0 Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein (By similarity). Note=Specifically located in the principal piece of sperm tail (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 53 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Opisthokonta CATSPERG HGNC:25243 catsper channel auxiliary subunit gamma Q6ZRH7 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 50 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Deuterostomia Metazoa CAV1 HGNC:1527 caveolin 1, caveolae protein, 22kDa Q03135 Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae. Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) ,11498016,12732636,18632619,,15561729 endoplasmic reticulum membrane 20 1 plasma membrane plasma membrane Deuterostomia Bilateria Metazoa CAV2 HGNC:1528 caveolin 2 P51636 Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 8552590,12496259,9361015,10464308 endoplasmic reticulum membrane 21 2 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Euteleostomi Bilateria Eumetazoa CAV3 HGNC:1529 caveolin 3 P56539 Golgi apparatus membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Membrane, caveola; Peripheral membrane protein (By similarity). Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11904769,15682833,11115849,14600260,18985008,11904769,14600260 endoplasmic reticulum membrane 18 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Metazoa CBFA2T2 HGNC:1536 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 O43439 Nucleus (Probable). Nucleoplasm (GO:0005654) 9787195,12242670 nucleus 58 0 nucleus nucleus Euteleostomi Bilateria Eukaryota CBFA2T3 HGNC:1537 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 O75081 Isoform 1: Nucleus, nucleolus. Isoform 2: Nucleus, nucleoplasm. Golgi apparatus membrane. Nucleus (GO:0005634); Nucleolus (GO:0005730);Nucleolus (GO:0005730); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12242670,12242670/12242670,14703694,11823486,11823486,14703694,12242670,11823486 nucleus 70 0 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Bilateria Opisthokonta CBFB HGNC:1539 core-binding factor, beta subunit Q13951 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8351518,12495904,17081983,9191054,9264408 cytoplasm 21 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa CBL HGNC:1541 Cbl proto-oncogene, E3 ubiquitin protein ligase P22681 Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane. Cytosol (GO:0005829); Endosome (GO:0005768); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cell projection (GO:0042995) 15708858,15708858,8702998,11001060,15708858,11067845,17255943 cytoplasm 54 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Eukaryota CBLB HGNC:1542 Cbl proto-oncogene B, E3 ubiquitin protein ligase Q13191 Cytoplasm. Note=Upon EGF stimulation, associates with endocytic vesicles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7784085,9614102,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota CBLC HGNC:15961 Cbl proto-oncogene C, E3 ubiquitin protein ligase Q9ULV8 Nucleus (Potential). Cytoplasm (GO:0005737) cytoplasm 38 0 cytoplasm cytoplasm Human Human Eukaryota CBLL1 HGNC:21225 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase Q75N03 cytoplasm 45 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CBLN1 HGNC:1543 cerebellin 1 precursor P23435 Secreted. Cell junction, synapse, postsynaptic cell membrane (By similarity). Plasma membrane (GO:0005886) 1704129 secreted 80 0 secreted secreted Theria Chordata Bilateria CBLN2 HGNC:1544 cerebellin 2 precursor Q8IUK8 Secreted (By similarity). Integral to membrane (GO:0016021) secreted 93 0 secreted secreted Eutheria Euteleostomi Bilateria CBLN3 HGNC:20146 cerebellin 3 precursor Q6UW01 Endoplasmic reticulum (By similarity). Golgi apparatus, cis-Golgi network (By similarity). Secreted (By similarity). Cell junction, synapse (By similarity). Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on a association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). Secreted (None) 17030622 secreted 52 0 secreted secreted Theria Theria Bilateria CBLN4 HGNC:16231 cerebellin 4 precursor Q9NTU7 Secreted (By similarity). Cell junction, synapse (By similarity). secreted 97 0 secreted secreted Euteleostomi Euteleostomi Bilateria CBR1 HGNC:1548 carbonyl reductase 1 P16152 Cytoplasm. Cytoplasm (GO:0005737) 12123751,3083821 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms CBR3 HGNC:1549 carbonyl reductase 3 O75828 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms CBR4 HGNC:25891 carbonyl reductase 4 Q8N4T8 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms CBS HGNC:1550 cystathionine-beta-synthase P35520 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 7598711 mitochondrion 27 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms CBWD1 HGNC:17134 COBW domain containing 1 Q9BRT8 cytoplasm 50 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CBWD2 HGNC:17907 COBW domain containing 2 Q8IUF1 cytoplasm 50 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CBWD3 HGNC:18519 COBW domain containing 3 Q5JTY5 cytoplasm 52 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA CBWD5 HGNC:24584 COBW domain containing 5 Q5RIA9 cytoplasm 54 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CBWD6 HGNC:31978 COBW domain containing 6 Q4V339 cytoplasm 51 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CBWD7 HGNC:31977 COBW domain containing 7 A6NM15 cytoplasm 62 0 cytoplasm cytoplasm Human Human Cell.Organisms CBX1 HGNC:1551 chromobox homolog 1 P83916 Nucleus. Note=Unassociated with chromosomes during mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9169582,12560554,10460410,10330177,17540172,17038565,17081983,10460410,11790298,15635413 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota CBX2 HGNC:1552 chromobox homolog 2 Q14781 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi NA CBX3 HGNC:1553 chromobox homolog 3 Q13185 Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 11124534,10330177,17540172,17038565,17081983,15635413,17540172,17081983 nucleus 99 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota CBX4 HGNC:1554 chromobox homolog 4 O00257 Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation. Nucleus (GO:0005634) 9315667,9199346,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota CBX5 HGNC:1555 chromobox homolog 5 P45973 Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Cytoplasm (GO:0005737) 10460410,17540172,17038565,15635413,17623812,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota CBX6 HGNC:1556 chromobox homolog 6 O95503 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 83 0 nucleus nucleus Euarchontoglires Euteleostomi Opisthokonta CBX7 HGNC:1557 chromobox homolog 7 O95931 Nucleus. Nucleus (GO:0005634) 14647293 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota CBX8 HGNC:15962 chromobox homolog 8 Q9HC52 Nucleus. Nucleus (GO:0005634) 10825164,11313972,17332741,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi NA CBY1 HGNC:1307 chibby homolog 1 (Drosophila) Q9Y3M2 Nucleus speckle. Golgi apparatus, trans- Golgi network. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12712206,15194699,15194699 nucleus 64 0 endoplasmic reticulum. golgi apparatus. nucleus multiple Euteleostomi Bilateria Metazoa CBY3 HGNC:33278 chibby homolog 3 (Drosophila) A6NI87 nucleus 65 0 nucleus nucleus Mammalia Mammalia Bilateria CC2D1A HGNC:30237 coiled-coil and C2 domain containing 1A Q6P1N0 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737) 16033914 nucleus 38 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CC2D1B HGNC:29386 coiled-coil and C2 domain containing 1B Q5T0F9 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota CC2D2A HGNC:29253 coiled-coil and C2 domain containing 2A Q9P2K1 Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota CC2D2B HGNC:31666 coiled-coil and C2 domain containing 2B Q6DHV5 cytoplasm 27 0 cytoplasm cytoplasm Mammalia Euteleostomi Eukaryota CCAR1 HGNC:24236 cell division cycle and apoptosis regulator 1 Q8IX12 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737) 12816952 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota CCAR2 HGNC:23360 cell cycle and apoptosis regulator 2 Q8N163 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15824730,17081983,15824730,17081983,15824730 cytoplasm 18 2 cytoplasm. mitochondrion. nucleus multiple Mammalia Bilateria Eukaryota CCBE1 HGNC:29426 collagen and calcium binding EGF domains 1 Q6UXH8 Secreted (Potential). Extracellular (GO:0005576) secreted 38 0 secreted secreted Euteleostomi Euteleostomi Eukaryota CCBL1 HGNC:1564 cysteine conjugate-beta lyase, cytoplasmic Q16773 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783) 8968194,8968194,2139845 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms CCBL2 HGNC:33238 cysteine conjugate-beta lyase 2 Q6YP21 cytoplasm 40 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CCDC101 HGNC:25156 coiled-coil domain containing 101 Q96ES7 Nucleus (By similarity). nucleus 98 0 nucleus nucleus Bilateria Eukaryota Eukaryota CCDC102A HGNC:28097 coiled-coil domain containing 102A Q96A19 secreted 5 0 secreted secreted Chordata Bilateria Eumetazoa CCDC102B HGNC:26295 coiled-coil domain containing 102B Q68D86 cytoplasm 6 0 cytoplasm cytoplasm Theria Theria Eumetazoa CCDC103 HGNC:32700 coiled-coil domain containing 103 Q8IW40 Cytoplasm (By similarity). Cell projection, cilium, flagellum (By similarity). nucleus 62 0 nucleus nucleus Theria Eukaryota Eukaryota CCDC104 HGNC:30540 coiled-coil domain containing 104 Q96G28 nucleus 61 0 nucleus nucleus Bilateria Eukaryota Eukaryota CCDC105 HGNC:26866 coiled-coil domain containing 105 Q8IYK2 cytoplasm 41 0 cytoplasm cytoplasm Theria Deuterostomia Metazoa CCDC106 HGNC:30181 coiled-coil domain containing 106 Q9BWC9 Nucleus. Note=Colocalizes with p53/TP53. nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Euteleostomi CCDC107 HGNC:28465 coiled-coil domain containing 107 Q8WV48 Membrane; Single-pass membrane protein (Potential). nucleus 34 1 nucleus nucleus Eutheria Eutheria Eutheria CCDC108 HGNC:25325 coiled-coil domain containing 108 Q6ZU64 Membrane; Single-pass membrane protein (Potential). nucleus 25 1 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms CCDC109B HGNC:26076 coiled-coil domain containing 109B Q9NWR8 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) mitochondrion membrane 36 2 mitochondrion membrane mitochondrion membrane Human Human Eukaryota CCDC11 HGNC:26530 coiled-coil domain containing 11 Q96M91 cytoplasm 12 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CCDC110 HGNC:28504 coiled-coil domain containing 110 Q8TBZ0 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Chromosome (GO:0005694) 15447989,15447989,15447989 nucleus 100 0 cytoplasm. nucleus multiple Amniota Amniota Bilateria CCDC112 HGNC:28599 coiled-coil domain containing 112 Q8NEF3 golgi apparatus membrane 15 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Eukaryota Eukaryota CCDC113 HGNC:25002 coiled-coil domain containing 113 Q9H0I3 cytoplasm 12 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota CCDC114 HGNC:26560 coiled-coil domain containing 114 Q96M63 Cell projection, cilium. cytoplasm 9 0 cytoplasm cytoplasm Eutheria Chordata Eukaryota CCDC115 HGNC:28178 coiled-coil domain containing 115 Q96NT0 Endosome (By similarity). Lysosome (By similarity). nucleus 63 0 nucleus nucleus Theria Eukaryota Metazoa CCDC116 HGNC:26688 coiled-coil domain containing 116 Q8IYX3 nucleus 86 0 nucleus nucleus Theria Theria Mammalia CCDC117 HGNC:26599 coiled-coil domain containing 117 Q8IWD4 nucleus 89 0 nucleus nucleus Mammalia Tetrapoda Euteleostomi CCDC12 HGNC:28332 coiled-coil domain containing 12 Q8WUD4 nucleus 63 0 nucleus nucleus Bilateria Eukaryota Eukaryota CCDC120 HGNC:28910 coiled-coil domain containing 120 Q96HB5 cytoplasm 16 0 cytoplasm cytoplasm Mammalia Euteleostomi Bilateria CCDC121 HGNC:25833 coiled-coil domain containing 121 Q6ZUS5 cytoplasm 3 0 cytoplasm cytoplasm Mammalia Mammalia Mammalia CCDC122 HGNC:26478 coiled-coil domain containing 122 Q5T0U0 secreted 7 0 secreted secreted Tetrapoda Tetrapoda Deuterostomia CCDC124 HGNC:25171 coiled-coil domain containing 124 Q96CT7 cytoplasm 88 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CCDC125 HGNC:28924 coiled-coil domain containing 125 Q86Z20 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia NA CCDC126 HGNC:22398 coiled-coil domain containing 126 Q96EE4 Secreted (Potential). golgi apparatus membrane 47 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eumetazoa CCDC127 HGNC:30520 coiled-coil domain containing 127 Q96BQ5 cytoplasm 86 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Deuterostomia CCDC129 HGNC:27363 coiled-coil domain containing 129 Q6ZRS4 cytoplasm 47 0 cytoplasm cytoplasm Mammalia Deuterostomia Craniata CCDC13 HGNC:26358 coiled-coil domain containing 13 Q8IYE1 cytoplasm 15 0 cytoplasm cytoplasm NA NA Eukaryota CCDC130 HGNC:28118 coiled-coil domain containing 130 P13994 Nucleus (GO:0005634) 17081983 nucleus 22 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CCDC132 HGNC:25956 coiled-coil domain containing 132 Q96JG6 golgi apparatus 17 1 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota CCDC134 HGNC:26185 coiled-coil domain containing 134 Q9H6E4 Secreted (Potential). nucleus 71 0 nucleus nucleus Deuterostomia Bilateria Holozoa CCDC135 HGNC:25289 coiled-coil domain containing 135 Q8IY82 Cell projection, cilium, flagellum (By similarity). cytoplasm 61 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota CCDC136 HGNC:22225 coiled-coil domain containing 136 Q96JN2 Membrane; Single-pass membrane protein (Potential). nucleus 15 1 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi CCDC137 HGNC:33451 coiled-coil domain containing 137 Q6PK04 nucleus 98 0 nucleus nucleus Theria Deuterostomia Eumetazoa CCDC138 HGNC:26531 coiled-coil domain containing 138 Q96M89 secreted 12 0 secreted secreted Deuterostomia Deuterostomia Eumetazoa CCDC14 HGNC:25766 coiled-coil domain containing 14 Q49A88 cytoplasm 11 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria CCDC140 HGNC:26514 coiled-coil domain containing 140 Q96MF4 nucleus 63 0 nucleus nucleus Homininae Homininae Eutheria CCDC141 HGNC:26821 coiled-coil domain containing 141 Q6ZP82 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa CCDC142 HGNC:25889 coiled-coil domain containing 142 Q17RM4 nucleus 53 0 nucleus nucleus Theria Chordata Eumetazoa CCDC144A HGNC:29072 coiled-coil domain containing 144A A2RUR9 cytoplasm 13 1 cytoplasm cytoplasm Amniota Amniota Eumetazoa CCDC144NL HGNC:33735 coiled-coil domain containing 144 family, N-terminal like Q6NUI1 nucleus 34 0 nucleus nucleus Homininae Homininae Primates CCDC146 HGNC:29296 coiled-coil domain containing 146 Q8IYE0 nucleus 13 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota CCDC147 HGNC:26676 coiled-coil domain containing 147 Q5T655 nucleus 17 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota CCDC148 HGNC:25191 coiled-coil domain containing 148 Q8NFR7 nucleus 6 0 nucleus nucleus Tetrapoda Chordata Eukaryota CCDC149 HGNC:25405 coiled-coil domain containing 149 Q6ZUS6 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta CCDC15 HGNC:25798 coiled-coil domain containing 15 Q0P6D6 secreted 12 0 secreted secreted Amniota Chordata Opisthokonta CCDC150 HGNC:26834 coiled-coil domain containing 150 Q8NCX0 nucleus 16 0 nucleus nucleus Theria Deuterostomia Eukaryota CCDC151 HGNC:28303 coiled-coil domain containing 151 A5D8V7 golgi apparatus membrane 14 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Eukaryota Eukaryota CCDC152 HGNC:34438 coiled-coil domain containing 152 Q4G0S7 cytoplasm 16 0 cytoplasm cytoplasm Theria Deuterostomia Deuterostomia CCDC153 HGNC:27446 coiled-coil domain containing 153 Q494R4 cytoplasm 15 0 cytoplasm cytoplasm NA NA Eukaryota CCDC154 HGNC:34454 coiled-coil domain containing 154 A6NI56 Early endosome. secreted 11 0 endosome endosome Theria Deuterostomia Bilateria CCDC155 HGNC:26520 coiled-coil domain containing 155 Q8N6L0 Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (Potential). Nucleus. Chromosome, telomere (By similarity). Note=Localized exclusively at telomeres from the leptotene to diplotene stages (By similarity). cytoplasm 18 1 nucleus nucleus Amniota Amniota Eukaryota CCDC157 HGNC:33854 coiled-coil domain containing 157 Q569K6 cytoplasm 8 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa CCDC158 HGNC:26374 coiled-coil domain containing 158 Q5M9N0 secreted 15 0 secreted secreted Mammalia Deuterostomia Bilateria CCDC159 HGNC:26996 coiled-coil domain containing 159 P0C7I6 nucleus 44 0 nucleus nucleus Human Mammalia Amniota CCDC160 HGNC:37286 coiled-coil domain containing 160 A6NGH7 cytoplasm 13 0 cytoplasm cytoplasm Mammalia Deuterostomia Craniata CCDC166 HGNC:41910 coiled-coil domain containing 166 P0CW27 cytoplasm 9 0 cytoplasm cytoplasm NA NA NA CCDC167 HGNC:21239 coiled-coil domain containing 167 Q9P0B6 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 9 1 nucleus nucleus Tetrapoda Euteleostomi Metazoa CCDC168 HGNC:26851 coiled-coil domain containing 168 Q8NDH2 nucleus 92 0 nucleus nucleus Eutheria Eutheria Eutheria CCDC169 HGNC:34361 coiled-coil domain containing 169 A6NNP5 nucleus 54 0 nucleus nucleus NA NA Eumetazoa CCDC17 HGNC:26574 coiled-coil domain containing 17 Q96LX7 Nucleus (GO:0005634) cytoplasm 88 0 cytoplasm cytoplasm Mammalia Tetrapoda Eumetazoa CCDC170 HGNC:21177 coiled-coil domain containing 170 Q8IYT3 nucleus 12 0 nucleus nucleus Deuterostomia Bilateria Metazoa CCDC171 HGNC:29828 coiled-coil domain containing 171 Q6TFL3 cytoplasm 14 2 cytoplasm cytoplasm Mammalia Deuterostomia Eumetazoa CCDC172 HGNC:30524 coiled-coil domain containing 172 P0C7W6 cytoplasm 9 0 cytoplasm cytoplasm Amniota Deuterostomia Bilateria CCDC173 HGNC:25064 coiled-coil domain containing 173 Q0VFZ6 nucleus 19 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta CCDC174 HGNC:28033 coiled-coil domain containing 174 Q6PII3 nucleus 87 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta CCDC175 HGNC:19847 coiled-coil domain containing 175 P0C221 nucleus 12 0 nucleus nucleus Mammalia Deuterostomia Bilateria CCDC176 HGNC:19855 coiled-coil domain containing 176 Q8ND07 nucleus 10 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota CCDC177 HGNC:23243 coiled-coil domain containing 177 Q9NQR7 cytoplasm 15 1 cytoplasm cytoplasm NA NA Boreoeutheria CCDC178 HGNC:29588 coiled-coil domain containing 178 Q5BJE1 cytoplasm 7 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Eumetazoa CCDC179 HGNC:44653 coiled-coil domain containing 179 H3BU77 nucleus 18 0 nucleus nucleus NA NA Boreoeutheria CCDC18 HGNC:30370 coiled-coil domain containing 18 Q5T9S5 Cytoplasm (GO:0005737) cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa CCDC180 HGNC:29303 coiled-coil domain containing 180 Q9P1Z9 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 14 2 nucleus nucleus Human Eukaryota Holozoa CCDC181 HGNC:28051 coiled-coil domain containing 181 Q5TID7 nucleus 24 0 nucleus nucleus Deuterostomia Deuterostomia Bilateria CCDC182 HGNC:49392 coiled-coil domain containing 182 A6NF36 cytoplasm 30 0 cytoplasm cytoplasm NA NA Mammalia CCDC183 HGNC:28236 coiled-coil domain containing 183 Q5T5S1 cytoplasm 45 0 cytoplasm cytoplasm Amniota Amniota Eumetazoa CCDC184 HGNC:33749 coiled-coil domain containing 184 Q52MB2 secreted 41 0 secreted secreted Theria Theria Mammalia CCDC19 HGNC:17229 coiled-coil domain containing 19 Q9UL16 Mitochondrion (Potential). cytoplasm 17 0 cytoplasm cytoplasm NA NA Eukaryota CCDC22 HGNC:28909 coiled-coil domain containing 22 O60826 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA CCDC23 HGNC:29204 coiled-coil domain containing 23 Q8N300 nucleus 37 0 nucleus nucleus Theria Theria Eumetazoa CCDC24 HGNC:28688 coiled-coil domain containing 24 Q8N4L8 nucleus 70 0 nucleus nucleus Mammalia Deuterostomia Eumetazoa CCDC25 HGNC:25591 coiled-coil domain containing 25 Q86WR0 cytoplasm 32 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CCDC27 HGNC:26546 coiled-coil domain containing 27 Q2M243 cytoplasm 13 0 cytoplasm cytoplasm Amniota Deuterostomia Bilateria CCDC28A HGNC:21098 coiled-coil domain containing 28A Q8IWP9 cytoplasm 45 0 cytoplasm cytoplasm Amniota Euteleostomi Eumetazoa CCDC28B HGNC:28163 coiled-coil domain containing 28B Q9BUN5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=It localizes near centrosomes and basal bodies. cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Metazoa CCDC3 HGNC:23813 coiled-coil domain containing 3 Q9BQI4 Secreted (By similarity). secreted 90 0 secreted secreted Euteleostomi Euteleostomi Chordata CCDC30 HGNC:26103 coiled-coil domain containing 30 Q5VVM6 nucleus 16 0 nucleus nucleus Mammalia Euteleostomi Euteleostomi CCDC33 HGNC:26552 coiled-coil domain containing 33 Q8N5R6 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota CCDC34 HGNC:25079 coiled-coil domain containing 34 Q96HJ3 cytoplasm 24 0 cytoplasm cytoplasm Theria Euteleostomi Chordata CCDC36 HGNC:27945 coiled-coil domain containing 36 Q8IYA8 nucleus 87 0 nucleus nucleus Theria Amniota Euteleostomi CCDC37 HGNC:26842 coiled-coil domain containing 37 Q494V2 cytoplasm 8 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CCDC38 HGNC:26843 coiled-coil domain containing 38 Q502W7 cytoplasm 23 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota CCDC39 HGNC:25244 coiled-coil domain containing 39 Q9UFE4 Cytoplasm, cytoskeleton, cilium axoneme. Note=DC40 is required for localization to axonemes. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CCDC40 HGNC:26090 coiled-coil domain containing 40 Q4G0X9 Cytoplasm (By similarity). Cell projection, cilium (By similarity). Note=Localizes to cytoplasm and motile cilium (By similarity). cytoplasm 16 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota CCDC42 HGNC:26528 coiled-coil domain containing 42 Q96M95 nucleus 8 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota CCDC42B HGNC:37100 coiled-coil domain containing 42B A6NFT4 cytoplasm 91 0 cytoplasm cytoplasm Eutheria Bilateria Eukaryota CCDC43 HGNC:26472 coiled-coil domain containing 43 Q96MW1 nucleus 86 0 nucleus nucleus Deuterostomia Bilateria Eumetazoa CCDC47 HGNC:24856 coiled-coil domain containing 47 Q96A33 Membrane; Single-pass membrane protein (Potential). Mitochondrion (GO:0005739) 15598749 endoplasmic reticulum membrane 15 1 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota CCDC50 HGNC:18111 coiled-coil domain containing 50 Q8IVM0 Cytoplasm. Note=Associated with microtubules of the cytoskeleton and mitotic apparatus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Bilateria CCDC51 HGNC:25714 coiled-coil domain containing 51 Q96ER9 Membrane; Multi-pass membrane protein (Potential). cytoplasm 69 2 cytoplasm cytoplasm Bilateria Bilateria Eumetazoa CCDC53 HGNC:24256 coiled-coil domain containing 53 Q9Y3C0 nucleus 42 0 nucleus nucleus Bilateria Bilateria Eukaryota CCDC54 HGNC:30703 coiled-coil domain containing 54 Q8NEL0 nucleus 50 1 nucleus nucleus Mammalia Mammalia Mammalia CCDC57 HGNC:27564 coiled-coil domain containing 57 Q2TAC2 cytoplasm 17 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Metazoa CCDC58 HGNC:31136 coiled-coil domain containing 58 Q4VC31 nucleus 21 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta CCDC59 HGNC:25005 coiled-coil domain containing 59 Q9P031 Nucleus (Probable). nucleus 93 0 nucleus nucleus Euteleostomi Deuterostomia Craniata CCDC6 HGNC:18782 coiled-coil domain containing 6 Q16204 Cytoplasm. Cytoplasm, cytoskeleton (Probable). Note=May be a cytoskeletal protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8058316,14712216,17081983,14712216,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota CCDC60 HGNC:28610 coiled-coil domain containing 60 Q8IWA6 nucleus 85 0 nucleus nucleus Tetrapoda Deuterostomia Eumetazoa CCDC61 HGNC:33629 coiled-coil domain containing 61 Q9Y6R9 cytoplasm 65 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota CCDC62 HGNC:30723 coiled-coil domain containing 62 Q6P9F0 Cytoplasm. Nucleus. Note=Mainly nuclear. cytoplasm 13 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Holozoa CCDC63 HGNC:26669 coiled-coil domain containing 63 Q8NA47 cytoplasm 12 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CCDC64 HGNC:28095 coiled-coil domain containing 64 Q6ZP65 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Localizes around the centrosome (By similarity). cytoplasm 93 0 cytoplasm cytoplasm Chordata Bilateria Eumetazoa CCDC64B HGNC:33584 coiled-coil domain containing 64B A1A5D9 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa CCDC65 HGNC:29937 coiled-coil domain containing 65 Q8IXS2 cytoplasm 5 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota CCDC66 HGNC:27709 coiled-coil domain containing 66 A2RUB6 nucleus 17 0 nucleus nucleus Deuterostomia Deuterostomia Bilateria CCDC67 HGNC:26344 coiled-coil domain containing 67 Q05D60 cytoplasm 17 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Metazoa CCDC68 HGNC:24350 coiled-coil domain containing 68 Q9H2F9 cytoplasm 15 0 cytoplasm cytoplasm Mammalia Mammalia Bilateria CCDC69 HGNC:24487 coiled-coil domain containing 69 A6NI79 cytoplasm 16 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Olfactores CCDC7 HGNC:26533 coiled-coil domain containing 7 Q96M83 nucleus 8 0 nucleus nucleus NA Eutheria Boreoeutheria CCDC70 HGNC:25303 coiled-coil domain containing 70 Q6NSX1 Secreted (Potential). secreted 13 0 secreted secreted Mammalia Mammalia Cell.Organisms CCDC71 HGNC:25760 coiled-coil domain containing 71 Q8IV32 nucleus 84 0 nucleus nucleus Mammalia Tetrapoda Euteleostomi CCDC71L HGNC:26685 coiled-coil domain containing 71-like Q8N9Z2 nucleus 46 0 nucleus nucleus NA NA Euteleostomi CCDC73 HGNC:23261 coiled-coil domain containing 73 Q6ZRK6 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Metazoa CCDC74A HGNC:25197 coiled-coil domain containing 74A Q96AQ1 cytoplasm 26 0 cytoplasm cytoplasm Mammalia Deuterostomia Eumetazoa CCDC74B HGNC:25267 coiled-coil domain containing 74B Q96LY2 cytoplasm 26 0 cytoplasm cytoplasm Mammalia Deuterostomia Metazoa CCDC77 HGNC:28203 coiled-coil domain containing 77 Q9BR77 cytoplasm 12 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CCDC78 HGNC:14153 coiled-coil domain containing 78 A2IDD5 Cytoplasm, perinuclear region. Cell membrane, sarcolemma. Sarcoplasmic reticulum. Note=Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm. cytoplasm 9 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Deuterostomia Eumetazoa CCDC79 HGNC:26675 coiled-coil domain containing 79 Q8NA31 nucleus 51 0 nucleus nucleus Chordata Chordata Metazoa CCDC8 HGNC:25367 coiled-coil domain containing 8 Q9H0W5 nucleus 28 0 nucleus nucleus Eutheria Eutheria Eukaryota CCDC80 HGNC:30649 coiled-coil domain containing 80 Q76M96 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 15325258 secreted 81 0 secreted secreted Euteleostomi Euteleostomi Craniata CCDC81 HGNC:26281 coiled-coil domain containing 81 Q6ZN84 cytoplasm 9 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota CCDC82 HGNC:26282 coiled-coil domain containing 82 Q8N4S0 Cytoplasm (GO:0005737) 17081983 nucleus 9 0 cytoplasm cytoplasm Tetrapoda Opisthokonta Bilateria CCDC83 HGNC:28535 coiled-coil domain containing 83 Q8IWF9 cytoplasm 71 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa CCDC84 HGNC:30460 coiled-coil domain containing 84 Q86UT8 nucleus 24 0 nucleus nucleus Euteleostomi Eukaryota NA CCDC85A HGNC:29400 coiled-coil domain containing 85A Q96PX6 secreted 49 0 secreted secreted Euteleostomi Bilateria Metazoa CCDC85B HGNC:24926 coiled-coil domain containing 85B Q15834 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. secreted 43 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa CCDC85C HGNC:35459 coiled-coil domain containing 85C A6NKD9 Cell junction, tight junction (By similarity). Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain (By similarity). Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall (By similarity). secreted 93 0 secreted secreted Human Human Metazoa CCDC86 HGNC:28359 coiled-coil domain containing 86 Q9H6F5 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17300783,17081983,17081983 nucleus 70 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota CCDC87 HGNC:25579 coiled-coil domain containing 87 Q9NVE4 Cytoplasm (GO:0005737) nucleus 90 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta CCDC88A HGNC:25523 coiled-coil domain containing 88A Q3V6T2 Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. Cytoskeleton (GO:0005856); Plasma membrane (GO:0005886) 16139227,16139227 cytoplasm 4 0 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta CCDC88B HGNC:26757 coiled-coil domain containing 88B A6NC98 cytoplasm 5 0 cytoplasm cytoplasm Eutheria Eutheria Holozoa CCDC88C HGNC:19967 coiled-coil domain containing 88C Q9P219 Cytoplasm (GO:0005737) cytoplasm 4 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CCDC89 HGNC:26762 coiled-coil domain containing 89 Q8N998 Cytoplasm (By similarity). Nucleus (By similarity). Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1 (By similarity). nucleus 18 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa CCDC9 HGNC:24560 coiled-coil domain containing 9 Q9Y3X0 Nucleus (GO:0005634) 17081983 nucleus 71 0 nucleus nucleus Theria Chordata Eumetazoa CCDC90B HGNC:28108 coiled-coil domain containing 90B Q9GZT6 Mitochondrion. Membrane; Single-pass membrane protein (Potential). mitochondrion membrane 38 1 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota CCDC91 HGNC:24855 coiled-coil domain containing 91 Q7Z6B0 Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Colocalizes with GGA1 and GGA2. May be recruited to the TGN by GGA1 and GGA2. Cytoplasm (GO:0005737) 12808037 secreted 17 0 cytoplasm cytoplasm Theria Deuterostomia Metazoa CCDC92 HGNC:29563 coiled-coil domain containing 92 Q53HC0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Metazoa CCDC93 HGNC:25611 coiled-coil domain containing 93 Q567U6 cytoplasm 10 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota CCDC94 HGNC:25518 coiled-coil domain containing 94 Q9BW85 Nucleus (GO:0005634) 17081983 nucleus 11 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CCDC96 HGNC:26900 coiled-coil domain containing 96 Q2M329 Nucleus (GO:0005634) nucleus 17 0 nucleus nucleus Theria Eukaryota Eukaryota CCDC97 HGNC:28289 coiled-coil domain containing 97 Q96F63 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 68 0 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota CCER1 HGNC:28373 coiled-coil glutamate-rich protein 1 Q8TC90 nucleus 13 0 nucleus nucleus Euarchontoglires Eutheria Eutheria CCER2 HGNC:44662 coiled-coil glutamate-rich protein 2 I3L3R5 cytoplasm 78 0 cytoplasm cytoplasm NA NA Boreoeutheria CCHCR1 HGNC:13930 coiled-coil alpha-helical rod protein 1 Q8TD31 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Endosome (GO:0005768); Nucleus (GO:0005634) 12909641,11875053,14675183,12909641,12909641,11875053,14675183 cytoplasm 16 0 cytoplasm. endosome. mitochondrion. nucleus multiple Deuterostomia Deuterostomia NA CCIN HGNC:1568 calicin Q13939 Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus. Cytoplasm (GO:0005737) 11090452,7641791 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms CCK HGNC:1569 cholecystokinin P06307 Secreted. Extracellular (GO:0005576) 12065614 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata CCKAR HGNC:1570 cholecystokinin A receptor P32238 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8343165 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Metazoa CCKBR HGNC:1571 cholecystokinin B receptor P32239 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7681836 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa CCL1 HGNC:10609 chemokine (C-C motif) ligand 1 P22362 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 2809212,1557400,10942748,12489497,11133740,2212659,11818437,10942748 secreted 100 0 cytoplasm. secreted multiple Eutheria Amniota Euteleostomi CCL11 HGNC:10610 chemokine (C-C motif) ligand 11 P51671 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10642580,8631813 secreted 100 0 cytoplasm. secreted multiple Euarchontoglires Euteleostomi Euteleostomi CCL13 HGNC:10611 chemokine (C-C motif) ligand 13 Q99616 Secreted. Extracellular (GO:0005576) 11342433,9195948 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi CCL14 HGNC:10612 chemokine (C-C motif) ligand 14 Q16627 Secreted. Extracellular (GO:0005576) 10978165,14718574,8551235 secreted 100 0 secreted secreted Homininae Eutheria Craniata CCL15 HGNC:10613 chemokine (C-C motif) ligand 15 Q16663 Secreted. Extracellular (GO:0005576) 9600961 secreted 100 0 secreted secreted Homininae Homininae NA CCL16 HGNC:10614 chemokine (C-C motif) ligand 16 O15467 Secreted. Extracellular (GO:0005576) 11470772 secreted 100 0 secreted secreted Human Eutheria Craniata CCL17 HGNC:10615 chemokine (C-C motif) ligand 17 Q92583 Secreted. Extracellular (GO:0005576) 8702936,11468146 secreted 100 0 secreted secreted Amniota Amniota Craniata CCL18 HGNC:10616 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) P55774 Secreted. Extracellular (GO:0005576) 11745396 secreted 100 0 secreted secreted Catarrhini Catarrhini Craniata CCL19 HGNC:10617 chemokine (C-C motif) ligand 19 Q99731 Secreted. Extracellular (GO:0005576) 9498785 secreted 100 0 secreted secreted Amniota Euteleostomi Euteleostomi CCL2 HGNC:10618 chemokine (C-C motif) ligand 2 P13500 Secreted. Extracellular (GO:0005576) 8195247 secreted 100 0 secreted secreted Eutheria Amniota Euteleostomi CCL20 HGNC:10619 chemokine (C-C motif) ligand 20 P78556 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11133838,12528183,9038201,11133838 secreted 100 0 cytoplasm. secreted multiple Amniota Amniota Craniata CCL21 HGNC:10620 chemokine (C-C motif) ligand 21 O00585 Secreted. Extracellular (GO:0005576) 14726959 secreted 100 0 secreted secreted Theria Euteleostomi Craniata CCL22 HGNC:10621 chemokine (C-C motif) ligand 22 O00626 Secreted. Extracellular (GO:0005576) 11352815,12407016,12851650,14718574 secreted 100 0 secreted secreted Mammalia Euteleostomi Euteleostomi CCL23 HGNC:10622 chemokine (C-C motif) ligand 23 P55773 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Euteleostomi CCL24 HGNC:10623 chemokine (C-C motif) ligand 24 O00175 Secreted. Extracellular (GO:0005576) 14718574 secreted 100 0 secreted secreted Theria Theria NA CCL25 HGNC:10624 chemokine (C-C motif) ligand 25 O15444 Secreted. Extracellular (GO:0005576) 9285413 secreted 100 0 secreted secreted Eutheria Euteleostomi Euteleostomi CCL26 HGNC:10625 chemokine (C-C motif) ligand 26 Q9Y258 Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11748272,11748272 secreted 100 0 secreted secreted Theria Theria NA CCL27 HGNC:10626 chemokine (C-C motif) ligand 27 Q9Y4X3 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12133963,10559234,12133963,10559234,11821900 secreted 100 0 cytoplasm. nucleus. secreted multiple Eutheria Euteleostomi Mammalia CCL28 HGNC:17700 chemokine (C-C motif) ligand 28 Q9NRJ3 Secreted. Extracellular (GO:0005576) 10975800 secreted 100 0 secreted secreted Eutheria Euteleostomi Olfactores CCL3 HGNC:10627 chemokine (C-C motif) ligand 3 P10147 Secreted. Extracellular (GO:0005576) 9207199 secreted 100 0 secreted secreted Amniota Euteleostomi Craniata CCL3L1 HGNC:10628 chemokine (C-C motif) ligand 3-like 1 P16619 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Eutheria Craniata CCL3L3 HGNC:30554 chemokine (C-C motif) ligand 3-like 3 P16619 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted NA NA NA CCL4 HGNC:10630 chemokine (C-C motif) ligand 4 P13236 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11470920,2247088,2462251,2521882,2809212,12070155,2462251,11278300 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Amniota Euteleostomi Craniata CCL4L1 HGNC:10631 chemokine (C-C motif) ligand 4-like 1 Q8NHW4 Secreted (By similarity). Extracellular (GO:0005576) 2247088,14673550 secreted 96 0 secreted secreted Human Human NA CCL4L2 HGNC:24066 chemokine (C-C motif) ligand 4-like 2 Q8NHW4 Secreted (By similarity). Extracellular (GO:0005576) 2247088 secreted 96 0 secreted secreted Human Human Euteleostomi CCL5 HGNC:10632 chemokine (C-C motif) ligand 5 P13501 Secreted. Extracellular (GO:0005576) 11976403,11959378 secreted 100 0 secreted secreted Theria Amniota NA CCL7 HGNC:10634 chemokine (C-C motif) ligand 7 P80098 Secreted. Extracellular (GO:0005576) 12149192,16002730 secreted 100 0 secreted secreted Euarchontoglires Eutheria Craniata CCL8 HGNC:10635 chemokine (C-C motif) ligand 8 P80075 Secreted. Extracellular (GO:0005576) 8189067 secreted 100 0 secreted secreted Theria Theria Craniata CCM2 HGNC:21708 cerebral cavernous malformation 2 Q9BSQ5 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 93 0 cytoplasm cytoplasm Amniota Deuterostomia Holozoa CCM2L HGNC:16153 cerebral cavernous malformation 2-like Q9NUG4 cytoplasm 34 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa CCNA1 HGNC:1577 cyclin A1 P78396 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10926775,10068472,10926775 nucleus 28 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CCNA2 HGNC:1578 cyclin A2 P20248 Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Centrosome (GO:0005813); Endosome (GO:0005768) 10525536,8502485,8024548,1387877,9020058 nucleus 21 0 cytoplasm. endoplasmic reticulum. endosome. nucleus multiple Bilateria Eukaryota Eukaryota CCNB1 HGNC:1579 cyclin B1 P14635 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Centrosome (GO:0005813); Nucleolus (GO:0005730) 9679058,12738867,12009577,7737117,10716937,1387877,9679058,12738867,12009577,10716937,10716937,1387877,15635413 nucleus 20 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota CCNB1IP1 HGNC:19437 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase Q9NPC3 Nucleus. Chromosome. Note=May associate with segregating chromosomes during metaphase and anaphase. Nucleus (GO:0005634) 12612082 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota CCNB2 HGNC:1580 cyclin B2 O95067 Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 7737117,8070405,14718574 nucleus 20 0 cytoplasm. golgi apparatus. secreted multiple Eukaryota Eukaryota Eukaryota CCNB3 HGNC:18709 cyclin B3 Q8WWL7 Nucleus. Nucleus (GO:0005634) 12185076,8313904 nucleus 100 0 nucleus nucleus Bilateria Eukaryota NA CCNC HGNC:1581 cyclin C P24863 Nucleus (Probable). Nucleus (GO:0005634) 11416138 nucleus 65 1 nucleus nucleus Opisthokonta Eukaryota Eukaryota CCND1 HGNC:1582 cyclin D1 P24385 Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9837900,15558026,9837900 nucleus 12 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota CCND2 HGNC:1583 cyclin D2 P30279 Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9858559,9858559,16182291 nucleus 11 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota CCND3 HGNC:1585 cyclin D3 P30281 Nucleus. Cytoplasm. Membrane. Note=Cyclin D- CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9858559,10342870,9858559,10342870,15358120 nucleus 10 0 cytoplasm. nucleus multiple Theria Bilateria Eukaryota CCNDBP1 HGNC:1587 cyclin D-type binding-protein 1 O95273 Cytoplasm. Nucleus. Extracellular (GO:0005576); Nucleus (GO:0005634) 10801854,10854051 nucleus 75 0 cytoplasm. nucleus. secreted multiple Tetrapoda Deuterostomia Metazoa CCNE1 HGNC:1589 cyclin E1 P24864 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 7739542,11221854,11221854 nucleus 100 1 nucleus nucleus Bilateria Eukaryota Eukaryota CCNE2 HGNC:1590 cyclin E2 O96020 Nucleus. Nucleus (GO:0005634) 9840943 nucleus 100 1 nucleus nucleus Euteleostomi Euteleostomi Eukaryota CCNF HGNC:1591 cyclin F P41002 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus. Nucleus (GO:0005634) 7813445,10716937,10531037 nucleus 14 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota CCNG1 HGNC:1592 cyclin G1 P51959 Nucleus. Note=DNA replication foci after DNA damage. Nucleus (GO:0005634) 10196184 nucleus 100 0 nucleus nucleus Human Euteleostomi Eukaryota CCNG2 HGNC:1593 cyclin G2 Q16589 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11956189,11956189 nucleus 41 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota CCNH HGNC:1594 cyclin H P51946 Nucleus. Nucleus (GO:0005634) 9243502,17081983 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota CCNI HGNC:1595 cyclin I Q14094 nucleus 17 0 nucleus nucleus Deuterostomia Opisthokonta Eukaryota CCNI2 HGNC:33869 cyclin I family, member 2 Q6ZMN8 nucleus 12 2 nucleus nucleus Euteleostomi Bilateria Eukaryota CCNJ HGNC:23434 cyclin J Q5T5M9 Nucleus (GO:0005634) nucleus 8 0 nucleus nucleus Euteleostomi Bilateria Eukaryota CCNJL HGNC:25876 cyclin J-like Q8IV13 cytoplasm 47 2 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota CCNK HGNC:1596 cyclin K O75909 Nucleus (GO:0005634);Nucleus (GO:0005634) 10574912/17081983 plasma membrane 23 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CCNL1 HGNC:20569 cyclin L1 Q9UK58 Nucleus speckle (By similarity). Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11683997,11683997,17081983 nucleus 95 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CCNL2 HGNC:20570 cyclin L2 Q96S94 Nucleus speckle. Nucleus (GO:0005634) 14684736,14623875 nucleus 100 0 nucleus nucleus NA NA Eukaryota CCNO HGNC:18576 cyclin O P22674 Nucleus (GO:0005634) 10393198,9490791 nucleus 21 1 nucleus nucleus Mammalia Euteleostomi Eukaryota CCNT1 HGNC:1599 cyclin T1 O60563 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11713532,9491887,12942536,11504720,11504720,11504720 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota CCNT2 HGNC:1600 cyclin T2 O60583 Nucleus. Nucleus (GO:0005634) 9499409,12037672 nucleus 100 0 nucleus nucleus Chordata Bilateria Eukaryota CCNY HGNC:23354 cyclin Y Q8ND76 Cell membrane; Lipid-anchor; Cytoplasmic side. Isoform 3: Nucleus. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) ,16253997,19524571,,,19524571,,,19524571, nucleus 42 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota CCNYL1 HGNC:26868 cyclin Y-like 1 Q8N7R7 nucleus 26 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota CCNYL2 HGNC:23495 cyclin Y-like 2 Q5T2Q4 nucleus 26 0 nucleus nucleus Catarrhini Catarrhini Eukaryota CCP110 HGNC:24342 centriolar coiled coil protein 110kDa O43303 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Metazoa CCPG1 HGNC:24227 cell cycle progression 1 Q9ULG6 Cytoplasmic granule membrane; Single-pass type II membrane protein (By similarity). cytoplasm 14 1 cytoplasm cytoplasm NA NA Craniata CCR1 HGNC:1602 chemokine (C-C motif) receptor 1 P32246 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14530297 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa CCR10 HGNC:4474 chemokine (C-C motif) receptor 10 P46092 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7851889 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Bilateria CCR2 HGNC:1603 chemokine (C-C motif) receptor 2 P41597 Cell membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8995400,9225989,11779135 plasma membrane 100 6 cytoplasm. plasma membrane multiple Tetrapoda Tetrapoda Eumetazoa CCR3 HGNC:1604 chemokine (C-C motif) receptor 3 P51677 Cell membrane; Multi-pass membrane protein. Secretory granule (GO:0030141); Plasma membrane (GO:0005886) 12654630,12218106,12654630 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa CCR4 HGNC:1605 chemokine (C-C motif) receptor 4 P51679 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10754297,12485447,12778466 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa CCR5 HGNC:1606 chemokine (C-C motif) receptor 5 (gene/pseudogene) P51681 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11336643 plasma membrane 100 6 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa CCR6 HGNC:1607 chemokine (C-C motif) receptor 6 P51684 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12193700 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa CCR7 HGNC:1608 chemokine (C-C motif) receptor 7 P32248 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12851649,12149218 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa CCR8 HGNC:1609 chemokine (C-C motif) receptor 8 P51685 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12163566 plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Eumetazoa CCR9 HGNC:1610 chemokine (C-C motif) receptor 9 P51686 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10229797 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa CCRL2 HGNC:1612 chemokine (C-C motif) receptor-like 2 O00421 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa CCRN4L HGNC:14254 CCR4 carbon catabolite repression 4-like (S. cerevisiae) Q9UK39 secreted 30 0 secreted secreted Tetrapoda Eukaryota Cell.Organisms CCS HGNC:1613 copper chaperone for superoxide dismutase O14618 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9726962,9726962 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CCSAP HGNC:29578 centriole, cilia and spindle-associated protein Q6IQ19 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, axon. Cell projection, cilium. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin. secreted 4 0 cytoplasm cytoplasm Amniota Euteleostomi Bilateria CCSER1 HGNC:29349 coiled-coil serine-rich protein 1 Q9C0I3 nucleus 90 0 nucleus nucleus Tetrapoda Euteleostomi Craniata CCSER2 HGNC:29197 coiled-coil serine-rich protein 2 Q9H7U1 nucleus 89 0 nucleus nucleus Amniota Euteleostomi Euteleostomi CCT2 HGNC:1615 chaperonin containing TCP1, subunit 2 (beta) P78371 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microtubule (GO:0005874); Mitochondrion (GO:0005739) ,9819444,18029348,,15635413,15561729,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms CCT3 HGNC:1616 chaperonin containing TCP1, subunit 3 (gamma) P49368 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microtubule (GO:0005874) 10635329,8573069,11790298,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Human Cell.Organisms Cell.Organisms CCT4 HGNC:1617 chaperonin containing TCP1, subunit 4 (delta) P50991 Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 9153422,8661059,15635413,15561729,15598749 cytoplasm 62 0 cytoplasm. melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms CCT5 HGNC:1618 chaperonin containing TCP1, subunit 5 (epsilon) P48643 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 11358150,7615668 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms CCT6A HGNC:1620 chaperonin containing TCP1, subunit 6A (zeta 1) P40227 Cytoplasm. Cytoplasm (GO:0005737); Microtubule (GO:0005874) 7953530,15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CCT6B HGNC:1621 chaperonin containing TCP1, subunit 6B (zeta 2) Q92526 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CCT7 HGNC:1622 chaperonin containing TCP1, subunit 7 (eta) Q99832 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 9819444,8982604,15561729,15598749 cytoplasm 95 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms CCT8 HGNC:1623 chaperonin containing TCP1, subunit 8 (theta) P50990 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 7890169,15561729,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms CCT8L2 HGNC:15553 chaperonin containing TCP1, subunit 8 (theta)-like 2 Q96SF2 Cytoplasm (By similarity). cytoplasm 25 0 cytoplasm cytoplasm Theria Theria Cell.Organisms CCZ1 HGNC:21691 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) P86791 Lysosome membrane. nucleus 14 0 nucleus nucleus Bilateria Eukaryota Eukaryota CCZ1B HGNC:21717 CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) P86790 Lysosome membrane. nucleus 14 0 nucleus nucleus Bilateria Eukaryota Eukaryota CD101 HGNC:5949 CD101 molecule Q93033 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 7722300 plasma membrane 20 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Chordata CD109 HGNC:21685 CD109 molecule Q6YHK3 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 11861284 secreted 14 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms CD14 HGNC:1628 CD14 molecule P08571 Cell membrane; Lipid-anchor, GPI-anchor. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Endosome (GO:0005768); Cell surface (GO:0009986); Cytoplasm (GO:0005737) 11489942,16188874,16473828,16473828,16473828,16473828,16473828,16473828 plasma membrane 16 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome. secreted multiple Amniota Amniota Tetrapoda CD151 HGNC:1630 CD151 molecule (Raph blood group) P48509 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Late endosome (GO:0005770); Perinuclear region (GO:0048471); Early endosome (GO:0005769) 9602068,10036233,10036233,10036233,10036233 golgi apparatus membrane 67 4 cytoplasm. endosome. plasma membrane multiple Euteleostomi Euteleostomi Holozoa CD160 HGNC:17013 CD160 molecule O95971 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 9973372,8090781 secreted 79 0 secreted secreted Euarchontoglires Eutheria Eutheria CD163 HGNC:1631 CD163 molecule Q86VB7 Soluble CD163: Secreted. Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 and isoform 2 show a lower surface expression when expressed in cells. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12115225,11334962,12208511,11334962,15448162,15479433,14962251 plasma membrane 39 1 plasma membrane. secreted multiple Tetrapoda Eukaryota Eukaryota CD163L1 HGNC:30375 CD163 molecule-like 1 Q9NR16 Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 2: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 3: Secreted (Probable). Plasma membrane (GO:0005886) 11086079 secreted 32 1 plasma membrane. secreted multiple Tetrapoda Eukaryota Eukaryota CD164 HGNC:1632 CD164 molecule, sialomucin Q04900 Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted (Potential). Plasma membrane (GO:0005886); Endosome (GO:0005768); Lysosome (GO:0005764) 11027692,11027692,11027692 endoplasmic reticulum membrane 77 1 endosome. endosome membrane. lysosome. lysosome membrane. plasma membrane multiple Amniota Euteleostomi Bilateria CD164L2 HGNC:32043 CD164 sialomucin-like 2 Q6UWJ8 Membrane; Single-pass type I membrane protein (Potential). secreted 76 1 secreted secreted Theria Theria Euteleostomi CD177 HGNC:30072 CD177 molecule Q8N6Q3 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 1382544,12239154,8301201 secreted 94 1 plasma membrane plasma membrane Eutheria Mammalia Mammalia CD180 HGNC:6726 CD180 molecule Q99467 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9763566 plasma membrane 100 1 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms CD19 HGNC:1633 CD19 molecule P15391 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9648915 secreted 46 3 plasma membrane plasma membrane Theria Theria Mammalia CD1A HGNC:1634 CD1a molecule P06126 Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts. Plasma membrane (GO:0005886) 2463622 secreted 13 1 plasma membrane plasma membrane Catarrhini Eutheria Craniata CD1B HGNC:1635 CD1b molecule P29016 Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Localizes to cell surface lipid rafts. Plasma membrane (GO:0005886) 2447586 secreted 13 1 plasma membrane plasma membrane Homininae Eutheria Craniata CD1C HGNC:1636 CD1c molecule P29017 Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Plasma membrane (GO:0005886); Endosome (GO:0005768) 12486100,11145857 plasma membrane 16 1 endosome. plasma membrane multiple Catarrhini Eutheria Craniata CD1D HGNC:1637 CD1d molecule P15813 Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764); Extracellular (GO:0005576) 2463622,11754812,1717564,11754812,11927549,11777966,14530337,11006091 secreted 10 1 cytoplasm. endoplasmic reticulum. endosome. lysosome. plasma membrane. secreted multiple Euarchontoglires Amniota Craniata CD1E HGNC:1638 CD1e molecule P15812 T-cell surface glycoprotein CD1e, membrane- associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. T-cell surface glycoprotein CD1e, soluble: Lysosome lumen. Golgi apparatus (GO:0005794); Endosome (GO:0005768); Lysosome (GO:0005764) 12671734,12671734,12671734 secreted 13 1 endosome. golgi apparatus. golgi apparatus membrane. lysosome multiple Human Eutheria Craniata CD2 HGNC:1639 CD2 molecule P06729 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1351089 nucleus 15 1 plasma membrane plasma membrane Theria Euteleostomi Euteleostomi CD200 HGNC:7203 CD200 molecule P41217 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11099416 plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Bilateria CD200R1 HGNC:24235 CD200 receptor 1 Q8TD46 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 4: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Plasma membrane (GO:0005886) 12960329 plasma membrane 48 1 plasma membrane. secreted multiple Amniota Amniota Euteleostomi CD200R1L HGNC:24665 CD200 receptor 1-like Q6Q8B3 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 41 1 plasma membrane plasma membrane Amniota Amniota Tetrapoda CD207 HGNC:17935 CD207 molecule, langerin Q9UJ71 Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Secretory granule (GO:0030141) 10661407,10661407,10661407 secreted 19 1 golgi apparatus. plasma membrane multiple Theria Theria NA CD209 HGNC:1641 CD209 molecule Q9NNX6 Isoform 1: Cell membrane; Single-pass type II membrane protein (Probable). Isoform 2: Cell membrane; Single-pass type II membrane protein (Probable). Isoform 3: Cell membrane; Single-pass type II membrane protein (Probable). Isoform 4: Cell membrane; Single-pass type II membrane protein (Probable). Isoform 5: Cell membrane; Single-pass type II membrane protein (Probable). Isoform 6: Secreted (Probable). Isoform 7: Secreted (Probable). Isoform 8: Secreted (Probable). Isoform 9: Secreted (Probable). Isoform 10: Secreted (Probable). Isoform 11: Secreted (Probable). Isoform 12: Secreted (Probable). Plasma membrane (GO:0005886); Endosome (GO:0005768); Lysosome (GO:0005764) 1518869,11337487,11859097,11859097,11859097 secreted 25 1 endosome. lysosome. plasma membrane. secreted multiple Euarchontoglires Euteleostomi Cell.Organisms CD22 HGNC:1643 CD22 molecule P20273 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9774390,9143697 plasma membrane 100 0 cytoplasm. plasma membrane multiple Theria Bilateria Cell.Organisms CD226 HGNC:16961 CD226 molecule Q15762 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 8673704 plasma membrane 17 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Bilateria CD24 HGNC:1645 CD24 molecule P25063 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 8928617 secreted 30 1 plasma membrane plasma membrane NA NA NA CD244 HGNC:18171 CD244 molecule, natural killer cell receptor 2B4 Q9BZW8 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9841922,12363025,12077228 plasma membrane 11 1 plasma membrane plasma membrane Eutheria Amniota Euteleostomi CD247 HGNC:1677 CD247 molecule P20963 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 3478717,16049493/2974162 plasma membrane 23 1 plasma membrane plasma membrane Theria Amniota Euteleostomi CD248 HGNC:18219 CD248 molecule, endosialin Q9HCU0 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 11084048,1438285 secreted 32 1 plasma membrane plasma membrane Euarchontoglires Euteleostomi Eukaryota CD27 HGNC:11922 CD27 molecule P26842 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1655907 secreted 18 1 plasma membrane plasma membrane Theria Theria Holozoa CD274 HGNC:17635 CD274 molecule Q9NZQ7 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12704383,12091876,12091876 plasma membrane 24 1 cytoplasm. endomembrane system. plasma membrane multiple Euteleostomi Euteleostomi Bilateria CD276 HGNC:19137 CD276 molecule Q5ZPR3 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 11224528 plasma membrane 12 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa CD28 HGNC:1653 CD28 molecule P10747 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2825196 plasma membrane 17 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi CD2AP HGNC:14258 CD2-associated protein Q9Y5K6 Cytoplasm, cytoskeleton (By similarity). Cell projection, ruffle (By similarity). Note=Colocalizes with F- actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. Cytoplasm (GO:0005737) 10339567,17081983 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota CD2BP2 HGNC:1656 CD2 (cytoplasmic tail) binding protein 2 O95400 Cytoplasm. Nucleus. Note=Predominantly nuclear. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9843987,17081983,15105431,17081983 nucleus 20 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota CD300A HGNC:19319 CD300a molecule Q9UGN4 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 1349532 plasma membrane 38 1 plasma membrane plasma membrane Eutheria Mammalia Craniata CD300C HGNC:19320 CD300c molecule Q08708 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 1349532 plasma membrane 38 1 plasma membrane plasma membrane Amniota Amniota Craniata CD300E HGNC:28874 CD300e molecule Q496F6 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 15557162 plasma membrane 100 1 plasma membrane plasma membrane Eutheria Euteleostomi Craniata CD300LB HGNC:30811 CD300 molecule-like family member b A8K4G0 Cell membrane; Single-pass type I membrane protein (By similarity). plasma membrane 47 1 plasma membrane plasma membrane Homininae Euteleostomi Craniata CD300LD HGNC:16848 CD300 molecule-like family member d Q6UXZ3 Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention. plasma membrane 100 1 plasma membrane plasma membrane Homininae Homininae Craniata CD300LF HGNC:29883 CD300 molecule-like family member f Q8TDQ1 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 15549731,15184070 plasma membrane 44 1 plasma membrane plasma membrane Mammalia Euteleostomi Craniata CD300LG HGNC:30455 CD300 molecule-like family member g Q6UXG3 Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single- pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 21 1 plasma membrane plasma membrane Mammalia Mammalia Craniata CD302 HGNC:30843 CD302 molecule Q8IX05 Membrane; Single-pass type I membrane protein (Potential). Cell projection, filopodium. Cytoplasm, cell cortex. Cell projection, microvillus. Note=Colocalizes with F- actin in filopodia, cellular cortex and microvilli of the apical cell surface. Plasma membrane (GO:0005886) plasma membrane 27 1 cytoplasm cytoplasm NA NA Eumetazoa CD320 HGNC:16692 CD320 molecule Q9NPF0 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10727470 endoplasmic reticulum membrane 38 1 plasma membrane plasma membrane Human Eutheria Metazoa CD33 HGNC:1659 CD33 molecule P20138 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7718872 plasma membrane 100 1 plasma membrane plasma membrane Theria Euteleostomi Euteleostomi CD34 HGNC:1662 CD34 molecule P28906 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576);Plasma membrane (GO:0005886) 7678811,9780190,2462139,1370171,12393633,14718574/7678811 secreted 15 1 plasma membrane. secreted multiple Amniota Amniota Tetrapoda CD36 HGNC:1663 CD36 molecule (thrombospondin receptor) P16671 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12169456,9555943 plasma membrane 12 2 plasma membrane plasma membrane Euteleostomi Eukaryota Eukaryota CD37 HGNC:1666 CD37 molecule P11049 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10529602,3257508,3257508 golgi apparatus membrane 59 4 cytoplasm. plasma membrane multiple Mammalia Tetrapoda Metazoa CD38 HGNC:1667 CD38 molecule P28907 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8253715,10559984 cytoplasm 16 1 nucleus. plasma membrane multiple Tetrapoda Deuterostomia Holozoa CD3D HGNC:1673 CD3d molecule, delta (CD3-TCR complex) P04234 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 76 1 plasma membrane plasma membrane Theria Amniota Euteleostomi CD3E HGNC:1674 CD3e molecule, epsilon (CD3-TCR complex) P07766 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12626537,7500045,9120393,8920877,1387664,8626450 plasma membrane 82 1 cytoplasm. nucleus. plasma membrane multiple Tetrapoda Euteleostomi Craniata CD3EAP HGNC:24219 CD3e molecule, epsilon associated protein O15446 Nucleus, nucleolus. Chromosome. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,9426281,15226435,,10373416,17081983,10373416 nucleus 100 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Craniata CD3G HGNC:1675 CD3g molecule, gamma (CD3-TCR complex) P09693 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1709425,1826255,7533164 plasma membrane 82 1 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi CD4 HGNC:1678 CD4 molecule P01730 Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. Plasma membrane (GO:0005886) 11854499 plasma membrane 100 1 plasma membrane plasma membrane Amniota Euteleostomi NA CD40 HGNC:11919 CD40 molecule, TNF receptor superfamily member 5 P25942 Isoform I: Cell membrane; Single-pass type I membrane protein. Isoform II: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10741409,11172023 secreted 20 1 cytoplasm. plasma membrane. secreted multiple Theria Euteleostomi Holozoa CD40LG HGNC:11935 CD40 ligand P29965 Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12718765,12676191,11493450,8626375 endoplasmic reticulum membrane 14 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Bilateria CD44 HGNC:1681 CD44 molecule (Indian blood group) P16070 Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) ,7529574,7516819,1694723,8599448,7499241,12032545,17912438,,9058761,17081983,17081983 secreted 87 1 cytoplasm. nucleus. plasma membrane multiple Tetrapoda Tetrapoda Eumetazoa CD46 HGNC:6953 CD46 molecule, complement regulatory protein P15529 Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide. Plasma membrane (GO:0005886) 10657632 secreted 19 1 plasma membrane plasma membrane Eutheria Tetrapoda Holozoa CD47 HGNC:1682 CD47 molecule Q08722 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Cell surface (GO:0009986) 7691831/1394148/1394148,2277087,7998989,18524990 plasma membrane 100 5 plasma membrane plasma membrane Amniota Amniota Amniota CD48 HGNC:1683 CD48 molecule P09326 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 11313125 plasma membrane 12 1 plasma membrane plasma membrane Eutheria Mammalia Euteleostomi CD5 HGNC:1685 CD5 molecule P06127 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9862202 plasma membrane 100 1 plasma membrane plasma membrane Amniota Amniota Eumetazoa CD52 HGNC:1804 CD52 molecule P31358 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 8366859 mitochondrion membrane 16 1 plasma membrane plasma membrane Catarrhini Catarrhini Primates CD53 HGNC:1686 CD53 molecule P19397 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11157846 golgi apparatus membrane 75 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa CD55 HGNC:2665 CD55 molecule, decay accelerating factor for complement (Cromer blood group) P08174 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Cell membrane; Lipid-anchor, GPI- anchor (Probable). Isoform 7: Cell membrane; Lipid-anchor, GPI- anchor (Probable). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9238658,9541601 secreted 21 0 plasma membrane. secreted multiple Theria Theria Opisthokonta CD58 HGNC:1688 CD58 molecule P19256 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11051456,9574540,11051456 plasma membrane 96 1 cytoplasm. plasma membrane multiple Theria Theria Euteleostomi CD59 HGNC:1689 CD59 molecule, complement regulatory protein P13987 Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8789559,2475570,7520819,1381503,2475570,8789559 secreted 39 0 cytoplasm. secreted multiple Amniota Euteleostomi Euteleostomi CD5L HGNC:1690 CD5 molecule-like O43866 Secreted. Extracellular (GO:0005576) 9045627 secreted 100 0 secreted secreted Theria Tetrapoda Eukaryota CD6 HGNC:1691 CD6 molecule P30203 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1919444 secreted 35 1 plasma membrane plasma membrane Mammalia Mammalia Eukaryota CD63 HGNC:1692 CD63 molecule P08962 Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note=Also found in Weibel- Palade bodies of endothelial cells. Located in platelet dense granules. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endosome (GO:0005768); Cytoplasm (GO:0005737); Cell surface (GO:0009986) 8661157,1993697,1993697,8661157,9822308,16917503 golgi apparatus membrane 70 4 cytoplasm. endosome. endosome membrane. lysosome. lysosome membrane. plasma membrane multiple Bilateria Bilateria Holozoa CD68 HGNC:1693 CD68 molecule P34810 Isoform Short: Cell membrane; Single-pass type I membrane protein. Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7680921 secreted 23 1 endosome membrane. lysosome membrane. plasma membrane multiple Theria Tetrapoda Euteleostomi CD69 HGNC:1694 CD69 molecule Q07108 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986) 10441371,8340758 plasma membrane 23 1 plasma membrane plasma membrane Tetrapoda Deuterostomia Eumetazoa CD7 HGNC:1695 CD7 molecule P09564 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1703303 plasma membrane 21 1 plasma membrane plasma membrane Theria Amniota Cell.Organisms CD70 HGNC:11937 CD70 molecule P32970 Membrane; Single-pass type II membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 15153937,15128787,8120384,10800994,9366422 secreted 41 1 plasma membrane. secreted multiple Theria Theria Mammalia CD72 HGNC:1696 CD72 molecule P21854 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 11466342 plasma membrane 24 1 plasma membrane plasma membrane Amniota Amniota Eumetazoa CD74 HGNC:1697 CD74 molecule, major histocompatibility complex, class II invariant chain P04233 Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Plasma membrane (GO:0005886) 2391366,2121367,11754812,2391366,8397411,8397411,6576808 secreted 35 1 endoplasmic reticulum. endosome. golgi apparatus. lysosome. plasma membrane multiple Euteleostomi Euteleostomi Eumetazoa CD79A HGNC:1698 CD79a molecule, immunoglobulin-associated alpha P11912 Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity). Plasma membrane (GO:0005886) 1538135 plasma membrane 100 1 plasma membrane plasma membrane Eutheria Eutheria NA CD79B HGNC:1699 CD79b molecule, immunoglobulin-associated beta P40259 Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity). Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8486355/8486355,8656670 plasma membrane 100 1 cytoplasm. plasma membrane multiple Amniota Amniota Euteleostomi CD80 HGNC:1700 CD80 molecule P33681 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1377173 plasma membrane 12 1 plasma membrane plasma membrane Theria Amniota Bilateria CD81 HGNC:1701 CD81 molecule P60033 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768) 12421929,12421929 golgi apparatus membrane 43 4 endosome. plasma membrane multiple Euarchontoglires Bilateria Holozoa CD82 HGNC:6210 CD82 molecule P27701 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14576349,11350933 golgi apparatus membrane 60 4 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa CD83 HGNC:1703 CD83 molecule Q01151 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10567699,1378080,12182451 plasma membrane 90 1 plasma membrane plasma membrane Theria Euteleostomi Craniata CD84 HGNC:1704 CD84 molecule Q9UIB8 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9310491,12928397 plasma membrane 100 1 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi CD86 HGNC:1705 CD86 molecule P42081 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7541777/7513726,15059478,14871408,11726649,12100033,12606712,10464129,11986949,11021528 plasma membrane 100 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Bilateria CD8A HGNC:1706 CD8a molecule P01732 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634);Extracellular (GO:0005576) 2536941,3871356,2496167,9299613,9299613/2496167,2536941 plasma membrane 92 1 cytoplasm. nucleus. plasma membrane. secreted multiple Tetrapoda Tetrapoda Euteleostomi CD8B HGNC:1707 CD8b molecule P10966 Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 2: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 3: Secreted (Probable). Isoform 4: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 5: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 6: Secreted (Probable). Isoform 7: Secreted (Probable). Isoform 8: Secreted (Probable). Plasma membrane (GO:0005886) 3145195 plasma membrane 91 1 plasma membrane. secreted multiple Amniota Amniota Cell.Organisms CD9 HGNC:1709 CD9 molecule P21926 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986) 9111230,8194524 golgi apparatus membrane 41 4 plasma membrane plasma membrane Chordata Chordata Holozoa CD93 HGNC:15855 CD93 molecule Q9NPY3 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8062452 secreted 27 1 plasma membrane plasma membrane Amniota Amniota Cell.Organisms CD96 HGNC:16892 CD96 molecule P40200 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1313846 plasma membrane 86 1 plasma membrane plasma membrane Theria Theria Bilateria CD97 HGNC:1711 CD97 molecule P48960 Cell membrane; Multi-pass membrane protein. CD97 antigen subunit alpha: Secreted, extracellular space. Plasma membrane (GO:0005886) 10540231 plasma membrane 57 7 plasma membrane. secreted multiple Mammalia Euteleostomi Cell.Organisms CD99 HGNC:7082 CD99 molecule P14209 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 2465491,2479542 secreted 32 1 cytoplasm cytoplasm Human Mammalia Tetrapoda CD99L2 HGNC:18237 CD99 molecule-like 2 Q8TCZ2 Cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity). Cell junction (By similarity). Extracellular (GO:0005576) 12975309 secreted 48 1 secreted secreted Amniota Euteleostomi NA CDA HGNC:1712 cytidine deaminase P32320 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10497201,9596658 cytoplasm 25 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms CDADC1 HGNC:20299 cytidine and dCMP deaminase domain containing 1 Q9BWV3 mitochondrion 13 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Cell.Organisms CDAN1 HGNC:1713 codanin 1 Q8IWY9 Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein (Potential). Note=Mainly detected as a cytoplasmic protein. Nucleus (GO:0005634) 12434312 cytoplasm 13 4 cytoplasm. nucleus multiple Deuterostomia Bilateria Eumetazoa CDC123 HGNC:16827 cell division cycle 123 O75794 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 9683532 cytoplasm 92 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CDC14A HGNC:1718 cell division cycle 14A Q9UNH5 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle. Nucleus (GO:0005634); Centrosome (GO:0005813) 9367992,12134069,11901424 nucleus 52 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CDC14B HGNC:1719 cell division cycle 14B O60729 Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1. Nucleus (GO:0005634) 9367992 nucleus 100 1 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CDC14C HGNC:22427 cell division cycle 14C A4D256 Membrane; Single-pass membrane protein (Potential). Nucleus, nucleolus. Note=Nucleolar during interphase (By similarity). nucleus 93 1 nucleus nucleus NA NA NA CDC16 HGNC:1720 cell division cycle 16 Q13042 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. Centrosome (GO:0005813) 7736578 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CDC20 HGNC:1723 cell division cycle 20 Q12834 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Centrosome (GO:0005813); Cytoplasm (GO:0005737); Kinetochore (GO:0000776) 12196507,9628895,9628895,9637688 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CDC20B HGNC:24222 cell division cycle 20B Q86Y33 cytoplasm 34 0 cytoplasm cytoplasm Theria Amniota Cell.Organisms CDC23 HGNC:1724 cell division cycle 23 Q9UJX2 Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 nucleus 21 0 nucleus nucleus Theria Eukaryota Cell.Organisms CDC25A HGNC:1725 cell division cycle 25A P30304 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11416155,11416155 cytoplasm 36 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota CDC25B HGNC:1726 cell division cycle 25B P30305 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813) 10822367,15456846,10822367,15456846,15128871 cytoplasm 100 0 cytoplasm. nucleus multiple Eutheria Bilateria Eukaryota CDC25C HGNC:1727 cell division cycle 25C P30307 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11933156,11933156 nucleus 100 0 cytoplasm. nucleus multiple Theria Bilateria Eukaryota CDC26 HGNC:17839 cell division cycle 26 Q8NHZ8 Nucleus (By similarity). nucleus 38 0 nucleus nucleus Eutheria Deuterostomia Bilateria CDC27 HGNC:1728 cell division cycle 27 P30260 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776) 9405394,12429948,15561729,9637688 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms CDC34 HGNC:1734 cell division cycle 34 P49427 Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10769200,10769200 nucleus 24 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CDC37 HGNC:1735 cell division cycle 37 Q16543 Cytoplasm. Cytoplasm (GO:0005737) 11413142 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CDC37L1 HGNC:17179 cell division cycle 37-like 1 Q7L3B6 Cytoplasm. Cytoplasm (GO:0005737) 11413142 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Holozoa CDC40 HGNC:17350 cell division cycle 40 O60508 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9830021,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CDC42 HGNC:1736 cell division cycle 42 P60953 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome. Cell junction (GO:0030054); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Microtubule cytoskeleton (GO:0015630); Apical membrane (GO:0016327); Cytosol (GO:0005829); Cell projection (GO:0042995) 9418861,11583574,11260256,11260256,15822942,14744859,17254974,17254974,9418861 cytoplasm 61 0 cytoplasm. secreted multiple Opisthokonta Opisthokonta Cell.Organisms CDC42BPA HGNC:1737 CDC42 binding protein kinase alpha (DMPK-like) Q5VT25 Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Cytoplasm (GO:0005737); Cell junction (GO:0030054) 9418861,9418861 cytoplasm 95 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms CDC42BPB HGNC:1738 CDC42 binding protein kinase beta (DMPK-like) Q9Y5S2 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell- cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42. Cytoplasm (GO:0005737) cytoplasm 54 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms CDC42BPG HGNC:29829 CDC42 binding protein kinase gamma (DMPK-like) Q6DT37 Cytoplasm. Note=Concentrates at the leading edge of cells. Cytoplasm (GO:0005737) 15194684 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms CDC42EP1 HGNC:17014 CDC42 effector protein (Rho GTPase binding) 1 Q00587 Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737);Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1629197,1629197,10430899/1629197,1629197,10430899,17081983,17081983 plasma membrane 27 0 cytoplasm. nucleus. secreted multiple Amniota Euteleostomi Bilateria CDC42EP2 HGNC:16263 CDC42 effector protein (Rho GTPase binding) 2 O14613 Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11035016,11035016 nucleus 89 0 cytoplasm cytoplasm Theria Euteleostomi Bilateria CDC42EP3 HGNC:16943 CDC42 effector protein (Rho GTPase binding) 3 Q9UKI2 Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) nucleus 88 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria CDC42EP4 HGNC:17147 CDC42 effector protein (Rho GTPase binding) 4 Q9H3Q1 Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11035016,11035016 nucleus 92 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria CDC42EP5 HGNC:17408 CDC42 effector protein (Rho GTPase binding) 5 Q6NZY7 Endomembrane system; Peripheral membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10490598,11035016,10490598,11035016 nucleus 84 0 cytoplasm cytoplasm Homininae Euteleostomi NA CDC42SE1 HGNC:17719 CDC42 small effector 1 Q9NRR8 Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Note=Recruited to the activated TCR prior actin polymerization. Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Plasma membrane (GO:0005886) 10816584,10816584,10816584 nucleus 40 0 cytoplasm cytoplasm Theria Euteleostomi Holozoa CDC42SE2 HGNC:18547 CDC42 small effector 2 Q9NRR3 Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages. Plasma membrane (GO:0005886) 10816584 nucleus 38 0 cytoplasm cytoplasm Human Tetrapoda Holozoa CDC45 HGNC:1739 cell division cycle 45 O75419 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9660782,9660782 nucleus 90 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CDC5L HGNC:1743 cell division cycle 5-like Q99459 Nucleus. Nucleus speckle. Cytoplasm. Note=May shuttle between cytoplasm and nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9598309,9038199,11101529,14576297,17081983,9038199 nucleus 36 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CDC6 HGNC:1744 cell division cycle 6 Q99741 Nucleus. Cytoplasm. Note=The protein is nuclear in G1 and cytoplasmic in S-phase cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9566895,10214964,11046155,9566895,11046155 nucleus 15 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms CDC7 HGNC:1745 cell division cycle 7 O00311 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9250678,9405610,9250678 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CDC73 HGNC:16783 cell division cycle 73 Q6P1J9 Nucleus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 15635413,16630820,15561729 nucleus 100 0 nucleus. nucleus membrane multiple Eukaryota Eukaryota Eukaryota CDCA2 HGNC:14623 cell division cycle associated 2 Q69YH5 Nucleus. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin. nucleus 100 0 nucleus nucleus Theria Amniota Bilateria CDCA3 HGNC:14624 cell division cycle associated 3 Q99618 Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12679038,17081983,17081983 cytoplasm 37 0 cytoplasm. nucleus multiple Amniota Amniota NA CDCA4 HGNC:14625 cell division cycle associated 4 Q9BXL8 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Deuterostomia CDCA5 HGNC:14626 cell division cycle associated 5 Q96FF9 Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown. Nucleus (GO:0005634) 17081983 nucleus 81 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Tetrapoda CDCA7 HGNC:14628 cell division cycle associated 7 Q9BWT1 Nucleus. Nucleus (GO:0005634) 11598121 nucleus 100 0 nucleus nucleus Chordata Chordata Eukaryota CDCA7L HGNC:30777 cell division cycle associated 7-like Q96GN5 Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 44 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Eukaryota CDCA8 HGNC:14629 cell division cycle associated 8 Q53HL2 Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. Nucleus (GO:0005634); Nucleolus (GO:0005730) 15249581,17081983,15635413 nucleus 24 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa CDCP1 HGNC:24357 CUB domain containing protein 1 Q9H5V8 Isoform 1: Cell membrane; Single-pass membrane protein (Potential). Isoform 3: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14739293,12660814,12660814 plasma membrane 53 1 cytoplasm. plasma membrane. secreted multiple Euteleostomi Euteleostomi Craniata CDCP2 HGNC:27297 CUB domain containing protein 2 Q5VXM1 Secreted (Potential). secreted 23 0 secreted secreted Amniota Euteleostomi Cell.Organisms CDH1 HGNC:1748 cadherin 1, type 1, E-cadherin (epithelial) P12830 Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Cell junction (GO:0030054) 10950951,10959047,10698519,10698519,10652321,12797865,10597309,,17057644,7542250,9405455, plasma membrane 56 1 cytoplasm. endosome. golgi apparatus. plasma membrane. secreted multiple Chordata Chordata Cell.Organisms CDH10 HGNC:1749 cadherin 10, type 2 (T2-cadherin) Q9Y6N8 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12389209 plasma membrane 91 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH11 HGNC:1750 cadherin 11, type 2, OB-cadherin (osteoblast) P55287 Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10320525,10550312,10550312 plasma membrane 100 1 cytoplasm. plasma membrane. secreted multiple Chordata Chordata Cell.Organisms CDH12 HGNC:1751 cadherin 12, type 2 (N-cadherin 2) P55289 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10191097,9122206 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH13 HGNC:1753 cadherin 13 P55290 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9650591,14718574 plasma membrane 29 1 plasma membrane. secreted multiple Tetrapoda Euteleostomi Cell.Organisms CDH15 HGNC:1754 cadherin 15, type 1, M-cadherin (myotubule) P55291 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8059975 plasma membrane 100 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms CDH16 HGNC:1755 cadherin 16, KSP-cadherin O75309 Cell membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 7615566,15023525,12851251,10409308 plasma membrane 74 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms CDH17 HGNC:1756 cadherin 17, LI cadherin (liver-intestine) Q12864 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 8153632 plasma membrane 74 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CDH18 HGNC:1757 cadherin 18, type 2 Q13634 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10207020,10861224 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH19 HGNC:1758 cadherin 19, type 2 Q9H159 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10995570 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH2 HGNC:1759 cadherin 2, type 1, N-cadherin (neuronal) P19022 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9508779 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH20 HGNC:1760 cadherin 20, type 2 Q9HBT6 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10995570 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH22 HGNC:13251 cadherin 22, type 2 Q9UJ99 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12630923,12630923 plasma membrane 94 1 cytoplasm. plasma membrane multiple Chordata Chordata Cell.Organisms CDH23 HGNC:13733 cadherin-related 23 Q9H251 Cell membrane; Single-pass type I membrane protein (By similarity). Centrosome (GO:0005813); Plasma membrane (GO:0005886) 15882574,11138008 plasma membrane 15 0 n/a n/a Bilateria Cell.Organisms Cell.Organisms CDH24 HGNC:14265 cadherin 24, type 2 Q86UP0 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Perinuclear region (GO:0048471) 12734196,12734196 plasma membrane 47 1 cytoplasm. plasma membrane multiple Chordata Chordata Cell.Organisms CDH26 HGNC:15902 cadherin 26 Q8IXH8 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 19 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CDH3 HGNC:1762 cadherin 3, type 1, P-cadherin (placental) P22223 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 8056851,10655458,9359492,10655458,11891861 plasma membrane 100 1 cytoplasm. plasma membrane. secreted multiple Chordata Chordata Cell.Organisms CDH4 HGNC:1763 cadherin 4, type 1, R-cadherin (retinal) P55283 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 798233 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH5 HGNC:1764 cadherin 5, type 2 (vascular endothelium) P33151 Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Plasma membrane (GO:0005886); Cell junction (GO:0030054) 12130501,17057644 plasma membrane 28 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CDH6 HGNC:1765 cadherin 6, type 2, K-cadherin (fetal kidney) P55285 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH7 HGNC:1766 cadherin 7, type 2 Q9ULB5 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 10995570 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH8 HGNC:1767 cadherin 8, type 2 P55286 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDH9 HGNC:1768 cadherin 9, type 2 (T1-cadherin) Q9ULB4 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 65 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CDHR1 HGNC:14550 cadherin-related family member 1 Q96JP9 Cell membrane; Single-pass membrane protein (By similarity). Note=Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region (By similarity). Plasma membrane (GO:0005886) plasma membrane 15 0 n/a n/a Euteleostomi Euteleostomi Cell.Organisms CDHR2 HGNC:18231 cadherin-related family member 2 Q9BYE9 Apical cell membrane; Single-pass type I membrane protein. Cell junction. Note=Present at the cell junctions and the apical surface of cells. Colocalizes with actin at the microvilli-like structures which protrude from the apical surface. Plasma membrane (GO:0005886) 12117771 plasma membrane 12 0 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CDHR3 HGNC:26308 cadherin-related family member 3 Q6ZTQ4 Cell membrane; Single-pass type I membrane protein (By similarity). plasma membrane 8 1 plasma membrane plasma membrane Tetrapoda Cell.Organisms Cell.Organisms CDHR4 HGNC:34527 cadherin-related family member 4 A6H8M9 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 4 1 plasma membrane plasma membrane Mammalia Mammalia Cell.Organisms CDHR5 HGNC:7521 cadherin-related family member 5 Q9HBB8 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Apical membrane (GO:0016327) 12167596,12167596 plasma membrane 14 1 plasma membrane plasma membrane Euarchontoglires Chordata Holozoa CDIP1 HGNC:13234 cell death-inducing p53 target 1 Q9H305 endoplasmic reticulum membrane 25 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Bilateria Eukaryota CDIPT HGNC:1769 CDP-diacylglycerol--inositol 3-phosphatidyltransferase O14735 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi- pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) ,, mitochondrion 20 5 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms CDK1 HGNC:1722 cyclin-dependent kinase 1 P06493 Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813); Nucleolus (GO:0005730); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 12612056,15662526,17081983,12612056,15662526,17081983,2686978,15311285,15635413,15561729,15598749 cytoplasm 56 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms CDK10 HGNC:1770 cyclin-dependent kinase 10 Q15131 nucleus 29 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms CDK11A HGNC:1730 cyclin-dependent kinase 11A Q9UQ88 Cytoplasm. Nucleus. nucleus 33 0 cytoplasm. nucleus multiple Human Eukaryota Cell.Organisms CDK11B HGNC:1729 cyclin-dependent kinase 11B P21127 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/2217177,15963510,2217177 nucleus 33 0 cytoplasm. nucleus multiple NA NA Cell.Organisms CDK12 HGNC:24224 cyclin-dependent kinase 12 Q9NYV4 Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase. Nucleus (GO:0005634) 11683387 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CDK13 HGNC:1733 cyclin-dependent kinase 13 Q14004 Nucleus speckle. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Nucleolus (GO:0005730) 17081983,17081983/11162436,15635413 nucleus 100 2 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CDK14 HGNC:8883 cyclin-dependent kinase 14 O94921 Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by NY. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9202329,11313143,16775625,9202329 cytoplasm 42 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms CDK15 HGNC:14434 cyclin-dependent kinase 15 Q96Q40 cytoplasm 38 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms CDK16 HGNC:8749 cyclin-dependent kinase 16 Q00536 Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome (By similarity). Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by NY. Cytoplasm (GO:0005737) 10099831,17081983 cytoplasm 42 0 cytoplasm cytoplasm Chordata Bilateria NA CDK17 HGNC:8750 cyclin-dependent kinase 17 Q00537 cytoplasm 43 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms CDK18 HGNC:8751 cyclin-dependent kinase 18 Q07002 cytoplasm 42 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms CDK19 HGNC:19338 cyclin-dependent kinase 19 Q9BWU1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14511641,14511641 nucleus 78 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CDK2 HGNC:1771 cyclin-dependent kinase 2 P24941 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11907280,10330164,11907280,15635413 cytoplasm 58 0 cytoplasm. endosome. nucleus multiple Eukaryota Eukaryota Cell.Organisms CDK20 HGNC:21420 cyclin-dependent kinase 20 Q8IZL9 Nucleus. Cytoplasm (By similarity). Cell projection, cilium (By similarity). Nucleus (GO:0005634) 14597612 nucleus 34 0 nucleus nucleus Mammalia Eukaryota Cell.Organisms CDK2AP1 HGNC:14002 cyclin-dependent kinase 2 associated protein 1 O14519 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9506968,9506968 nucleus 42 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Metazoa CDK2AP2 HGNC:30833 cyclin-dependent kinase 2 associated protein 2 O75956 nucleus 42 0 nucleus nucleus Theria Euteleostomi Metazoa CDK3 HGNC:1772 cyclin-dependent kinase 3 Q00526 Nucleus (GO:0005634) 12097586 cytoplasm 56 0 nucleus nucleus NA NA Cell.Organisms CDK4 HGNC:1773 cyclin-dependent kinase 4 P11802 Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. Cytoplasm (GO:0005737) 10788489 cytoplasm 33 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms CDK5 HGNC:1774 cyclin-dependent kinase 5 Q00535 Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Isoform 2: Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 8891282,8891282,11743029 cytoplasm 51 0 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CDK5R1 HGNC:1775 cyclin-dependent kinase 5, regulatory subunit 1 (p35) Q15078 Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11741927,15013773,15013773 nucleus 68 0 cytoplasm. nucleus multiple Theria Bilateria Metazoa CDK5R2 HGNC:1776 cyclin-dependent kinase 5, regulatory subunit 2 (p39) Q13319 Cell membrane; Lipid-anchor; Cytoplasmic side. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10923673,10923673,10683146,10683146 secreted 31 0 cytoplasm. secreted multiple Human Human Metazoa CDK5RAP1 HGNC:15880 CDK5 regulatory subunit associated protein 1 Q96SZ6 endoplasmic reticulum membrane 12 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms CDK5RAP2 HGNC:18672 CDK5 regulatory subunit associated protein 2 Q96SN8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends. Cytoplasm (GO:0005737); Centrosome (GO:0005813);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,15561729/17081983,17081983 cytoplasm 10 0 cytoplasm. golgi apparatus. nucleus multiple Amniota Chordata Opisthokonta CDK5RAP3 HGNC:18673 CDK5 regulatory subunit associated protein 3 Q96JB5 nucleus 64 0 nucleus nucleus Bilateria Eukaryota Eukaryota CDK6 HGNC:1777 cyclin-dependent kinase 6 Q00534 Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10514479,9164930,10514479,11804329 cytoplasm 35 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms CDK7 HGNC:1778 cyclin-dependent kinase 7 P50613 Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 15695176,15695176,8647641,15635413 nucleus 83 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota NA CDK8 HGNC:1779 cyclin-dependent kinase 8 P49336 Nucleus (Probable). Nucleus (GO:0005634) 11278802 nucleus 81 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CDK9 HGNC:1780 cyclin-dependent kinase 9 P50750 Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with NT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730);Cytoplasm (GO:0005737) 9258347,8170997,11282025,12894230,12386808,12115727,12037672,9258347,8170997,12386808,12115727,15635413/17081983 nucleus 44 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CDKAL1 HGNC:21050 CDK5 regulatory subunit associated protein 1-like 1 Q5VV42 Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms Cell.Organisms CDKL1 HGNC:1781 cyclin-dependent kinase-like 1 (CDC2-related kinase) Q00532 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 7595554 nucleus 29 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CDKL2 HGNC:1782 cyclin-dependent kinase-like 2 (CDC2-related kinase) Q92772 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) , nucleus 25 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms CDKL3 HGNC:15483 cyclin-dependent kinase-like 3 Q8IVW4 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12927787 cytoplasm 18 0 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms CDKL4 HGNC:19287 cyclin-dependent kinase-like 4 Q5MAI5 Cytoplasm (Probable). nucleus 31 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CDKL5 HGNC:11411 cyclin-dependent kinase-like 5 O76039 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms CDKN1A HGNC:1784 cyclin-dependent kinase inhibitor 1A (p21, Cip1) P38936 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9660939,16616141,12820963,9660939,16616141,12820963 nucleus 24 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eumetazoa CDKN1B HGNC:1785 cyclin-dependent kinase inhibitor 1B (p27, Kip1) P46527 Nucleus. Cytoplasm. Endosome (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Apical membrane (GO:0016327) 12244301,16326706,17254967,17053782,12244301,16326706,17254967,17053782,17254974 nucleus 32 0 cytoplasm. nucleus multiple Chordata Chordata Eumetazoa CDKN1C HGNC:1786 cyclin-dependent kinase inhibitor 1C (p57, Kip2) P49918 Nucleus (By similarity). Nucleus (GO:0005634) 10323243,7729683 nucleus 51 0 nucleus nucleus Human Euteleostomi Eumetazoa CDKN2A HGNC:1787 cyclin-dependent kinase inhibitor 2A P42771 Cytoplasm. Nucleus. Nucleolus (GO:0005730); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10360174,12740913,15811326,15811326 cytoplasm 82 0 cytoplasm. nucleus multiple Human Eutheria Cell.Organisms CDKN2AIP HGNC:24325 CDKN2A interacting protein Q9NXV6 Nucleus, nucleoplasm. Nucleolus (GO:0005730); Nucleus (GO:0005634) 12154087,12154087,19059367 nucleus 100 0 nucleus nucleus Theria Euteleostomi Deuterostomia CDKN2AIPNL HGNC:30545 CDKN2A interacting protein N-terminal like Q96HQ2 nucleus 30 0 nucleus nucleus NA NA Bilateria CDKN2B HGNC:1788 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) P42772 Cytoplasm. Note=Also found in the nucleus. Cytoplasm (GO:0005737) 9042862 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CDKN2C HGNC:1789 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) P42773 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8663131,8663131 cytoplasm 30 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms CDKN2D HGNC:1790 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) P55273 Nucleus. Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8741839,8741839 cytoplasm 38 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Cell.Organisms CDKN3 HGNC:1791 cyclin-dependent kinase inhibitor 3 Q16667 Cytoplasm, perinuclear region. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10669749,10669749 cytoplasm 100 1 cytoplasm. nucleus multiple Amniota Cell.Organisms Cell.Organisms CDNF HGNC:24913 cerebral dopamine neurotrophic factor Q49AH0 Secreted. secreted 100 0 secreted secreted Mammalia Tetrapoda Holozoa CDO1 HGNC:1795 cysteine dioxygenase type 1 Q16878 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms CDON HGNC:17104 cell adhesion associated, oncogene regulated Q4KMG0 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 77 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CDPF1 HGNC:33710 cysteine-rich, DPF motif domain containing 1 Q6NVV7 nucleus 28 0 nucleus nucleus Amniota Eukaryota Metazoa CDR1 HGNC:1798 cerebellar degeneration-related protein 1, 34kDa P51861 Plasma membrane (GO:0005886) 9159144,11328762 secreted 73 0 secreted secreted Human Euarchontoglires Boreoeutheria CDR2 HGNC:1799 cerebellar degeneration-related protein 2, 62kDa Q01850 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2014264,11988016,11988016 cytoplasm 12 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa CDR2L HGNC:29999 cerebellar degeneration-related protein 2-like Q86X02 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eumetazoa CDRT1 HGNC:14379 CMT1A duplicated region transcript 1 O95170 nucleus 9 0 nucleus nucleus NA NA Cell.Organisms CDRT15 HGNC:14395 CMT1A duplicated region transcript 15 Q96T59 secreted 69 0 secreted secreted NA NA Primates CDRT15L2 HGNC:34075 CMT1A duplicated region transcript 15-like 2 A8MXV6 Membrane; Single-pass membrane protein (Potential). secreted 73 1 secreted secreted Homininae Homininae Primates CDRT4 HGNC:14383 CMT1A duplicated region transcript 4 Q8N9R6 nucleus 46 0 nucleus nucleus NA NA Mammalia CDS1 HGNC:1800 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 Q92903 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Cytoplasmic aspect of the endoplasmic reticulum (By similarity). Integral to membrane (GO:0016021); Mitochondrion (GO:0005739); Microsome (GO:0005792); Endoplasmic reticulum (GO:0005783) 8863531,8863531,8863531, endoplasmic reticulum membrane 94 8 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms CDS2 HGNC:1801 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 O95674 Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side (Potential). Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737) /17081983,17081983 endoplasmic reticulum membrane 66 8 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CDSN HGNC:1802 corneodesmosin Q15517 Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9712893,11739386,11279026,11739386,7818278 secreted 100 0 secreted secreted Theria Theria NA CDT1 HGNC:24576 chromatin licensing and DNA replication factor 1 Q9H211 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10898791,11555648,17318181 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CDV3 HGNC:26928 CDV3 homolog (mouse) Q9UKY7 Cytoplasm (By similarity). Nucleus (GO:0005634) 10497265 cytoplasm 76 0 nucleus nucleus Deuterostomia Deuterostomia Eumetazoa CDX1 HGNC:1805 caudal type homeobox 1 P47902 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta CDX2 HGNC:1806 caudal type homeobox 2 Q99626 Nucleus. Nucleus (GO:0005634) 11733373,12559945 nucleus 100 0 nucleus nucleus Theria Amniota Eukaryota CDX4 HGNC:1808 caudal type homeobox 4 O14627 Nucleus (By similarity). Nucleus (GO:0005634) 14505364 nucleus 79 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota CDY1 HGNC:1809 chromodomain protein, Y-linked, 1 Q9Y6F8 Nucleus (By similarity). Nucleus (GO:0005634) 12072557 nucleus 54 1 nucleus nucleus Chordata Cell.Organisms Cell.Organisms CDY1B HGNC:23920 chromodomain protein, Y-linked, 1B Q9Y6F8 Nucleus (By similarity). Nucleus (GO:0005634) 14569460,12072557 nucleus 54 1 nucleus nucleus Chordata Cell.Organisms Cell.Organisms CDY2A HGNC:1810 chromodomain protein, Y-linked, 2A Q9Y6F7 Nucleus (By similarity). Nucleus (GO:0005634) 12072557 nucleus 53 1 nucleus nucleus Chordata Cell.Organisms Cell.Organisms CDY2B HGNC:23921 chromodomain protein, Y-linked, 2B Q9Y6F7 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 53 1 nucleus nucleus Chordata Cell.Organisms Cell.Organisms CDYL HGNC:1811 chromodomain protein, Y-like Q9Y232 Nucleus (By similarity). Nucleus (GO:0005634) 12072557,15561729 nucleus 87 1 nucleus nucleus Chordata Cell.Organisms Cell.Organisms CDYL2 HGNC:23030 chromodomain protein, Y-like 2 Q8N8U2 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 43 1 nucleus nucleus Theria Deuterostomia Cell.Organisms CEACAM1 HGNC:1814 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) P13688 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Cell membrane; Single-pass type I membrane protein. Isoform 6: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cell membrane; Single-pass type I membrane protein. Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of cell-cell contact. Vesicle (None); Plasma membrane (GO:0005886) 14522961,14522961 plasma membrane 47 0 plasma membrane. secreted multiple Amniota Euteleostomi Cell.Organisms CEACAM16 HGNC:31948 carcinoembryonic antigen-related cell adhesion molecule 16 Q2WEN9 Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane (By similarity). secreted 100 0 secreted secreted Mammalia Mammalia Metazoa CEACAM18 HGNC:31949 carcinoembryonic antigen-related cell adhesion molecule 18 A8MTB9 secreted 8 1 secreted secreted Eutheria Eutheria Bilateria CEACAM19 HGNC:31951 carcinoembryonic antigen-related cell adhesion molecule 19 Q7Z692 Membrane; Single-pass type I membrane protein (Potential). secreted 20 1 secreted secreted Theria Theria Tetrapoda CEACAM20 HGNC:24879 carcinoembryonic antigen-related cell adhesion molecule 20 Q6UY09 Membrane; Single-pass type I membrane protein (Potential). secreted 11 1 secreted secreted Theria Euteleostomi NA CEACAM21 HGNC:28834 carcinoembryonic antigen-related cell adhesion molecule 21 Q3KPI0 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 27 1 plasma membrane plasma membrane Human Euarchontoglires Eumetazoa CEACAM3 HGNC:1815 carcinoembryonic antigen-related cell adhesion molecule 3 P40198 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11708798 secreted 34 1 plasma membrane plasma membrane Human Euarchontoglires NA CEACAM4 HGNC:1816 carcinoembryonic antigen-related cell adhesion molecule 4 O75871 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2050678 plasma membrane 30 1 plasma membrane plasma membrane Catarrhini Euarchontoglires NA CEACAM5 HGNC:1817 carcinoembryonic antigen-related cell adhesion molecule 5 P06731 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 10816511,10931872 plasma membrane 38 1 plasma membrane plasma membrane Amniota Euteleostomi NA CEACAM6 HGNC:1818 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) P40199 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 3128509,3527416,2332039 plasma membrane 41 0 cytoplasm cytoplasm Homininae Mammalia NA CEACAM7 HGNC:1819 carcinoembryonic antigen-related cell adhesion molecule 7 Q14002 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Plasma membrane (GO:0005886) 7806520 plasma membrane 35 0 n/a n/a Human Human NA CEACAM8 HGNC:1820 carcinoembryonic antigen-related cell adhesion molecule 8 P31997 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 10520185 plasma membrane 43 0 n/a n/a Catarrhini Catarrhini Metazoa CEBPA HGNC:1833 CCAAT/enhancer binding protein (C/EBP), alpha P49715 Nucleus. Nucleus (GO:0005634) 9191024,12692227 nucleus 100 0 nucleus nucleus NA NA Metazoa CEBPB HGNC:1834 CCAAT/enhancer binding protein (C/EBP), beta P17676 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9495318,12692227,8855267,9495318 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa CEBPD HGNC:1835 CCAAT/enhancer binding protein (C/EBP), delta P49716 Nucleus. Nucleus (GO:0005634) 12937035 nucleus 100 0 nucleus nucleus NA NA Metazoa CEBPE HGNC:1836 CCAAT/enhancer binding protein (C/EBP), epsilon Q15744 Nucleus. Nucleus (GO:0005634) 9032264 nucleus 100 0 nucleus nucleus Mammalia Mammalia Holozoa CEBPG HGNC:1837 CCAAT/enhancer binding protein (C/EBP), gamma P53567 Nucleus. Nucleus (GO:0005634) 1709121,8089482,1377818 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa CEBPZ HGNC:24218 CCAAT/enhancer binding protein (C/EBP), zeta Q03701 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CECR1 HGNC:1839 cat eye syndrome chromosome region, candidate 1 Q9NZK5 Secreted. Extracellular (GO:0005576) 10756095 secreted 100 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms CECR2 HGNC:1840 cat eye syndrome chromosome region, candidate 2 Q9BXF3 nucleus 20 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota CECR5 HGNC:1843 cat eye syndrome chromosome region, candidate 5 Q9BXW7 Mitochondrion (GO:0005739) 15598749 mitochondrion 16 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota CECR6 HGNC:1844 cat eye syndrome chromosome region, candidate 6 Q9BXQ6 Integral to membrane (GO:0016021) plasma membrane 74 8 plasma membrane plasma membrane Theria Euteleostomi Craniata CEL HGNC:1848 carboxyl ester lipase P19835 Secreted. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 12853459,7588748,11148205,9774442 secreted 100 1 endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Bilateria Cell.Organisms CELA1 HGNC:3308 chymotrypsin-like elastase family, member 1 Q9UNI1 Secreted. Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023); Secretory granule (GO:0030141) 7634150,7634150,7634150 secreted 100 0 endoplasmic reticulum. secreted multiple Eutheria Euteleostomi Cell.Organisms CELA2A HGNC:24609 chymotrypsin-like elastase family, member 2A P08217 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Euarchontoglires Tetrapoda Cell.Organisms CELA2B HGNC:29995 chymotrypsin-like elastase family, member 2B P08218 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Homininae Homininae Cell.Organisms CELA3A HGNC:15944 chymotrypsin-like elastase family, member 3A P09093 Extracellular (GO:0005576) 2826474 secreted 78 0 secreted secreted Human Human Cell.Organisms CELA3B HGNC:15945 chymotrypsin-like elastase family, member 3B P08861 Extracellular (GO:0005576); Zymogen granule (GO:0042588) 2826474,16278343 secreted 84 0 secreted secreted Theria Bilateria Cell.Organisms CELF1 HGNC:2549 CUGBP, Elav-like family member 1 Q92879 Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11564876,8948631,8789448,11564876,8948631,8789448,8912635 mitochondrion 15 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CELF2 HGNC:2550 CUGBP, Elav-like family member 2 O95319 Nucleus. Cytoplasm. Note=Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12535526,12535526 nucleus 15 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CELF3 HGNC:11967 CUGBP, Elav-like family member 3 Q5SZQ8 Nucleus (By similarity). Cytoplasm (By similarity). Nucleus (GO:0005634) 11158314 nucleus 16 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms CELF4 HGNC:14015 CUGBP, Elav-like family member 4 Q9BZC1 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14973222,14973222 nucleus 16 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CELF5 HGNC:14058 CUGBP, Elav-like family member 5 Q8N6W0 Nucleus (By similarity). Cytoplasm (By similarity). Nucleus (GO:0005634) mitochondrion 16 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms CELF6 HGNC:14059 CUGBP, Elav-like family member 6 Q96J87 Nucleus (By similarity). Cytoplasm (By similarity). mitochondrion 20 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms CELSR1 HGNC:1850 cadherin, EGF LAG seven-pass G-type receptor 1 Q9NYQ6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886);Nucleus (GO:0005634) ,9339365/17081983 plasma membrane 100 7 nucleus. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms CELSR2 HGNC:3231 cadherin, EGF LAG seven-pass G-type receptor 2 Q9HCU4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms CELSR3 HGNC:3230 cadherin, EGF LAG seven-pass G-type receptor 3 Q9NYQ7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10790539 plasma membrane 100 7 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms CEMIP HGNC:29213 cell migration inducing protein, hyaluronan binding Q8WUJ3 Cytoplasm (GO:0005737) 14577002 secreted 20 1 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms CEMP1 HGNC:32553 cementum protein 1 Q6PRD7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Homininae Homininae Boreoeutheria CEND1 HGNC:24153 cell cycle exit and neuronal differentiation 1 Q8N111 Membrane; Single-pass type IV membrane protein (Potential). Mitochondrion (GO:0005739) 11311134 cytoplasm 21 1 mitochondrion mitochondrion Euarchontoglires Amniota Eutheria CENPA HGNC:1851 centromere protein A P49450 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height. Nucleus (GO:0005634); Chromosome (GO:0005694) 12019018,17623812 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota CENPB HGNC:1852 centromere protein B, 80kDa P07199 Nucleus. Chromosome, centromere. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Kinetochore (GO:0000776) 2335558,1740467,15635413,17623812,15561729 nucleus 100 0 nucleus nucleus Mammalia Eukaryota Eukaryota CENPBD1 HGNC:28272 CENPB DNA-binding domains containing 1 B2RD01 Nucleus (Potential). nucleus 12 0 nucleus nucleus NA NA Metazoa CENPC HGNC:1854 centromere protein C Q03188 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) 12490152,11925107,9261558,17081983,17623812,15561729 nucleus 100 0 nucleus nucleus Theria Theria Opisthokonta CENPE HGNC:1856 centromere protein E, 312kDa Q02224 Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division. Centrosome (GO:0005813); Chromosome (GO:0005694); Kinetochore (GO:0000776) 9391217,17623812,17093495,15561729 cytoplasm 24 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota CENPF HGNC:1857 centromere protein F, 350/400kDa P49454 Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body. Nucleus (GO:0005634); Kinetochore (GO:0000776); Cytoplasm (GO:0005737) 7542657,9950165,12154071,17363900,15561729,17081983 cytoplasm 5 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms CENPH HGNC:17268 centromere protein H Q9H3R5 Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC1 during both interphase and metaphase. Centrosome (GO:0005813); Nucleus (GO:0005634); Kinetochore (GO:0000776) 11092768,11092768,15561729 nucleus 100 0 nucleus nucleus Amniota Amniota Bilateria CENPI HGNC:3968 centromere protein I Q92674 Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. Kinetochore (GO:0000776) 15561729 nucleus 100 4 nucleus nucleus Deuterostomia Opisthokonta Opisthokonta CENPJ HGNC:17272 centromere protein J Q9HC77 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Nucleus (GO:0005634) 11003675,12198240,11003675,12198240,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota CENPK HGNC:29479 centromere protein K Q9BS16 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. Nucleus (GO:0005634) 10996314 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta CENPL HGNC:17879 centromere protein L Q8N0S6 Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. Cytosol (GO:0005829) 15561729 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Opisthokonta CENPM HGNC:18352 centromere protein M Q9NSP4 Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. Nucleus (GO:0005634) 15183305 cytoplasm 29 1 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Holozoa CENPN HGNC:30873 centromere protein N Q96H22 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis. nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Holozoa CENPO HGNC:28152 centromere protein O Q9BU64 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Holozoa CENPP HGNC:32933 centromere protein P Q6IPU0 Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. nucleus 100 0 nucleus nucleus Amniota Euteleostomi Holozoa CENPQ HGNC:21347 centromere protein Q Q7L2Z9 Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. nucleus 100 0 nucleus nucleus Amniota Amniota Deuterostomia CENPT HGNC:25787 centromere protein T Q96BT3 Nucleus. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus. Chromosome (GO:0005694) 16622419 nucleus 100 0 nucleus nucleus Amniota Amniota Opisthokonta CENPU HGNC:21348 centromere protein U Q71F23 Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15116101,15561729,15116101 nucleus 35 0 cytoplasm. nucleus multiple Theria Amniota Euteleostomi CENPV HGNC:29920 centromere protein V Q7Z7K6 Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12196509,15048159,15048159 nucleus 28 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms CENPW HGNC:21488 centromere protein W Q5EE01 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. nucleus 100 1 nucleus nucleus Euarchontoglires Amniota Euteleostomi CEP104 HGNC:24866 centrosomal protein 104kDa O60308 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CEP112 HGNC:28514 centrosomal protein 112kDa Q8N8E3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Localizes around spindle poles in some cells. cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CEP120 HGNC:26690 centrosomal protein 120kDa Q8N960 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Regulates the localization of TA3 to the centrosome in neural progenitors in vivo (By similarity). cytoplasm 87 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CEP128 HGNC:20359 centrosomal protein 128kDa Q6ZU80 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with the mother centriole. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa CEP131 HGNC:29511 centrosomal protein 131kDa Q9UPN4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813); Acrosome (GO:0001669) 14654843,15561729,9070930,8529672 cytoplasm 100 0 cytoplasm. lysosome multiple Euteleostomi Eukaryota Eukaryota CEP135 HGNC:29086 centrosomal protein 135kDa Q66GS9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CEP152 HGNC:29298 centrosomal protein 152kDa O94986 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Centrosome (GO:0005813) 14654843 cytoplasm 97 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa CEP162 HGNC:21107 centrosomal protein 162kDa Q5TB80 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis. cytoplasm 19 0 cytoplasm. nucleus multiple Amniota Deuterostomia Metazoa CEP164 HGNC:29182 centrosomal protein 164kDa Q9UPV0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1. cytoplasm 15 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota CEP170 HGNC:28920 centrosomal protein 170kDa Q5SW79 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms CEP170B HGNC:20362 centrosomal protein 170B Q9Y4F5 Cytoplasm, cytoskeleton (Probable). nucleus 28 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms CEP19 HGNC:28209 centrosomal protein 19kDa Q96LK0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CEP192 HGNC:25515 centrosomal protein 192kDa Q8TEP8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes. Centrosome (GO:0005813);Centrosome (GO:0005813) 14654843/14654843,15561729 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota CEP250 HGNC:1859 centrosomal protein 250kDa Q9BV73 Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Component of the core centrosome. In interphase cells, it specifically associates with the proximal ends of both mother and daughter centrioles. Associates with the centrosome in interphase cells. In mitotic cells, it dissociates from the mitotic spindle poles. At the end of cell division, it reaccumulates at centrosomes. In photoreceptors, found at the proximal ends of basal bodies. Centrosome (GO:0005813); Centriole (GO:0005814); Cytoplasm (GO:0005737) 12857871,12140259,11076968,9647649,15561729,12857871,12140259,11076968,9647649,9647649 cytoplasm 100 0 cytoplasm cytoplasm Theria Amniota Holozoa CEP290 HGNC:29021 centrosomal protein 290kDa O15078 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells. Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). cytoplasm 16 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Opisthokonta CEP350 HGNC:24238 centrosomal protein 350kDa Q5VT06 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the pericentrosomal area. Centrosome (GO:0005813) cytoplasm 21 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota CEP41 HGNC:12370 centrosomal protein 41kDa Q9BYV8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes mainly to the cilium basal body and in primary cilia. Centrosome (GO:0005813) 14654843 mitochondrion 60 0 cytoplasm cytoplasm Deuterostomia Bilateria NA CEP44 HGNC:29356 centrosomal protein 44kDa Q9C0F1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Localizes to centrosomes, spindle poles, and weakly in midbody. nucleus 72 0 cytoplasm cytoplasm Amniota Eukaryota Opisthokonta CEP55 HGNC:1161 centrosomal protein 55kDa Q53EZ4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. nucleus 12 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Chordata CEP57 HGNC:30794 centrosomal protein 57kDa Q86XR8 Nucleus (By similarity). Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Centrosome (GO:0005813) 12717444,15561729 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa CEP57L1 HGNC:21561 centrosomal protein 57kDa-like 1 Q8IYX8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). cytoplasm 13 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa CEP63 HGNC:25815 centrosomal protein 63kDa Q96MT8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with CEP152 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Centrosome (GO:0005813) 14654843 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa CEP68 HGNC:29076 centrosomal protein 68kDa Q76N32 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Euteleostomi Euteleostomi CEP70 HGNC:29972 centrosomal protein 70kDa Q8NHQ1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis. Centrosome (GO:0005813) 14654843 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eumetazoa CEP72 HGNC:25547 centrosomal protein 72kDa Q9P209 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner. Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14654843,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Eukaryota CEP76 HGNC:25727 centrosomal protein 76kDa Q8TAP6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Does not localize along the ciliary axoneme. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CEP78 HGNC:25740 centrosomal protein 78kDa Q5JTW2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms CEP83 HGNC:17966 centrosomal protein 83kDa Q9Y592 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to centrioles at all stages of the cell cycle, including mitosis. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Opisthokonta CEP85 HGNC:25309 centrosomal protein 85kDa Q6P2H3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles. nucleus 18 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota CEP85L HGNC:21638 centrosomal protein 85kDa-like Q5SZL2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (Probable). Note=Subcellular experiments using a GFP-tagged system produced a weak signal, rendering it difficult to confirm centrosome association. cytoplasm 17 0 cytoplasm cytoplasm Mammalia Euteleostomi Metazoa CEP89 HGNC:25907 centrosomal protein 89kDa Q96ST8 Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Mitochondrion intermembrane space. Note=Localizes to structures around centrosomes similar to centrosome satellites. Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa CEP95 HGNC:25141 centrosomal protein 95kDa Q96GE4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. cytoplasm 100 0 cytoplasm cytoplasm NA NA NA CEP97 HGNC:26244 centrosomal protein 97kDa Q8IW35 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centriole (GO:0005814) ,17719545, cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms CEPT1 HGNC:24289 choline/ethanolamine phosphotransferase 1 Q9Y6K0 Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 10191259 golgi apparatus membrane 57 14 endoplasmic reticulum membrane. nucleus membrane multiple Euteleostomi Eukaryota Cell.Organisms CER1 HGNC:1862 cerberus 1, DAN family BMP antagonist O95813 Secreted (Probable). Extracellular (GO:0005576) 9501024 secreted 59 0 secreted secreted Theria Euteleostomi Eumetazoa CERCAM HGNC:23723 cerebral endothelial cell adhesion molecule Q5T4B2 Endoplasmic reticulum lumen (Potential). endoplasmic reticulum 47 0 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms CERK HGNC:19256 ceramide kinase Q8TCT0 Cytoplasm. Membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 14769792,14769792,11956206,11956206,9837889,14769792 cytoplasm 18 0 cytoplasm. endoplasmic reticulum multiple Bilateria Eukaryota Cell.Organisms CERKL HGNC:21699 ceramide kinase-like Q49MI3 Cytoplasm. Nucleus, nucleolus. Isoform 2: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Cytoplasmic vesicle (GO:0016023); Nucleus (GO:0005634); Nucleolus (GO:0005730) 15708351,15708351,15708351 cytoplasm 34 1 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Tetrapoda Eukaryota Eukaryota CERS1 HGNC:14253 ceramide synthase 1 P27544 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Isoform 1 may recycle from the Golgi to the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12105227,12105227 endoplasmic reticulum membrane 14 7 endoplasmic reticulum. golgi apparatus multiple NA NA Eukaryota CERS2 HGNC:14076 ceramide synthase 2 Q96G23 Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 7 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota CERS3 HGNC:23752 ceramide synthase 3 Q8IU89 Nucleus membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634) endoplasmic reticulum membrane 82 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Eukaryota CERS4 HGNC:23747 ceramide synthase 4 Q9HA82 Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634) endoplasmic reticulum membrane 10 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota CERS5 HGNC:23749 ceramide synthase 5 Q8N5B7 Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634) endoplasmic reticulum membrane 12 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eukaryota Eukaryota CERS6 HGNC:23826 ceramide synthase 6 Q6ZMG9 Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 9 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota CES1 HGNC:1863 carboxylesterase 1 P23141 Endoplasmic reticulum lumen. Extracellular (GO:0005576) 1918003 endoplasmic reticulum 100 0 endoplasmic reticulum. secreted multiple Human Human NA CES2 HGNC:1864 carboxylesterase 2 O00748 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 9144407,9169443,15475733,9169443 endoplasmic reticulum 66 0 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms CES3 HGNC:1865 carboxylesterase 3 Q6UWW8 Endoplasmic reticulum lumen (By similarity). endoplasmic reticulum 58 0 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms CES4A HGNC:26741 carboxylesterase 4A Q5XG92 Secreted (Potential). endoplasmic reticulum 31 0 endoplasmic reticulum endoplasmic reticulum Theria Theria Cell.Organisms CES5A HGNC:26459 carboxylesterase 5A Q6NT32 Secreted (By similarity). endoplasmic reticulum 35 1 endoplasmic reticulum endoplasmic reticulum Eutheria Chordata NA CETN1 HGNC:1866 centrin, EF-hand protein, 1 Q12798 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosome of interphase and mitotic cells. Centrosome (GO:0005813) 8175926 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms CETN2 HGNC:1867 centrin, EF-hand protein, 2 P41208 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus (Probable). Note=Centrosome of S-phase, interphase and mitotic cells. Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8248209,17081983,17081983 cytoplasm 80 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA CETN3 HGNC:1868 centrin, EF-hand protein, 3 O15182 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosome of interphase and mitotic cells. Centrosome (GO:0005813) 9256449,17139249 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CETP HGNC:1869 cholesteryl ester transfer protein, plasma P11597 Secreted, extracellular space. Extracellular (GO:0005576) 3600759 secreted 100 0 secreted secreted Catarrhini Euteleostomi Eukaryota CFB HGNC:1037 complement factor B P00751 Secreted. Extracellular (GO:0005576) 6149579,16188874 secreted 100 0 secreted secreted Chordata Chordata NA CFC1 HGNC:18292 cripto, FRL-1, cryptic family 1 P0CG37 Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates. Plasma membrane (GO:0005886) 11062482 plasma membrane 39 0 secreted secreted Tetrapoda Tetrapoda Bilateria CFC1B HGNC:33983 cripto, FRL-1, cryptic family 1B P0CG36 Secreted (Potential). plasma membrane 39 0 n/a n/a NA NA Bilateria CFD HGNC:2771 complement factor D (adipsin) P00746 Secreted. Extracellular (GO:0005576) 824769 secreted 100 0 secreted secreted Euarchontoglires Euteleostomi Cell.Organisms CFDP1 HGNC:1873 craniofacial development protein 1 Q9UEE9 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 10415329,10350657,9602175,10350657,10415329,11992732 nucleus 20 0 cytoplasm. nucleus. secreted multiple Deuterostomia Opisthokonta Eukaryota CFH HGNC:4883 complement factor H P08603 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 2529127,16188874,9312129 secreted 100 0 endoplasmic reticulum. secreted multiple Tetrapoda Bilateria Holozoa CFHR1 HGNC:4888 complement factor H-related 1 Q03591 Secreted. Extracellular (GO:0005576) 10408366 secreted 100 0 secreted secreted NA NA Holozoa CFHR2 HGNC:4890 complement factor H-related 2 P36980 Secreted. Extracellular (GO:0005576) 7672821 secreted 100 0 secreted secreted Euarchontoglires Mammalia Metazoa CFHR3 HGNC:16980 complement factor H-related 3 Q02985 Secreted. secreted 100 0 secreted secreted Catarrhini Mammalia Holozoa CFHR4 HGNC:16979 complement factor H-related 4 Q92496 Secreted. Extracellular (GO:0005576) 10622723 secreted 100 0 secreted secreted Catarrhini Mammalia Holozoa CFHR5 HGNC:24668 complement factor H-related 5 Q9BXR6 Secreted. Extracellular (GO:0005576) 11774097,11058592 secreted 100 0 secreted secreted Tetrapoda Bilateria Holozoa CFI HGNC:5394 complement factor I P05156 Secreted, extracellular space. Extracellular (GO:0005576) 2956252,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CFL1 HGNC:1874 cofilin 1 (non-muscle) P23528 Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Microsome (GO:0005792); Cytosol (GO:0005829); Mitochondrion (GO:0005739) ,12049672,11950878,,8824278,12904289,11090694,14718574,16188874,12904289,12904289,15598749 cytoplasm 28 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota CFL2 HGNC:1875 cofilin 2 (muscle) Q9Y281 Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Nucleus (GO:0005634) 8824278,17081983,8824278,17081983 cytoplasm 29 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CFLAR HGNC:1876 CASP8 and FADD-like apoptosis regulator O15519 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11965497,11965497 cytoplasm 12 0 cytoplasm. nucleus multiple Amniota Euteleostomi Opisthokonta CFP HGNC:8864 complement factor properdin P27918 Secreted. Extracellular (GO:0005576) 11090881 secreted 100 0 secreted secreted Mammalia Euteleostomi Eukaryota CFTR HGNC:1884 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) P13569 Early endosome membrane; Multi-pass membrane protein. Cell membrane. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Apical membrane (GO:0016327) 12080183,11707463,16546175,16203867 mitochondrion 15 12 endoplasmic reticulum. endosome. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms CGA HGNC:1885 glycoprotein hormones, alpha polypeptide P01215 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 2481154,2449427,2449427 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Euteleostomi Craniata CGB HGNC:1886 chorionic gonadotropin, beta polypeptide P01233 Secreted. Secretory granule (GO:0030141); Extracellular (GO:0005576) 2447154,6194155 secreted 100 0 secreted secreted Human Human Deuterostomia CGB1 HGNC:16721 chorionic gonadotropin, beta polypeptide 1 A6NKQ9 Secreted. secreted 100 0 secreted secreted NA NA NA CGB2 HGNC:16722 chorionic gonadotropin, beta polypeptide 2 Q6NT52 Secreted. secreted 100 0 secreted secreted Catarrhini Euteleostomi Deuterostomia CGB5 HGNC:16452 chorionic gonadotropin, beta polypeptide 5 P01233 Secreted. secreted 100 0 secreted secreted Human Human Deuterostomia CGB7 HGNC:16451 chorionic gonadotropin, beta polypeptide 7 P01233 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted NA NA Deuterostomia CGB8 HGNC:16453 chorionic gonadotropin, beta polypeptide 8 P01233 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted NA NA Deuterostomia CGGBP1 HGNC:1888 CGG triplet repeat binding protein 1 Q9UFW8 Nucleus. Nuclear matrix (GO:0016363) 10692448,8626781,9201980 nucleus 100 0 nucleus nucleus Theria Amniota Metazoa CGN HGNC:17429 cingulin Q9P2M7 Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12529927, secreted 84 0 secreted secreted Euteleostomi Euteleostomi Holozoa CGNL1 HGNC:25931 cingulin-like 1 Q0VF96 Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). secreted 78 0 secreted secreted Euteleostomi Euteleostomi Holozoa CGREF1 HGNC:16962 cell growth regulator with EF-hand domain 1 Q99674 Secreted (By similarity). secreted 56 0 secreted secreted Theria Tetrapoda Eumetazoa CGRRF1 HGNC:15528 cell growth regulator with ring finger domain 1 Q99675 Nucleus. nucleus 100 1 nucleus nucleus Euteleostomi Bilateria Eukaryota CH25H HGNC:1907 cholesterol 25-hydroxylase O95992 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9852097,9852097 endoplasmic reticulum membrane 73 5 endoplasmic reticulum. golgi apparatus multiple Deuterostomia Bilateria Cell.Organisms CHAC1 HGNC:28680 ChaC, cation transport regulator homolog 1 (E. coli) Q9BUX1 Golgi apparatus, trans-Golgi network (By similarity). Cytoplasm, cytosol. cytoplasm 40 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms CHAC2 HGNC:32363 ChaC, cation transport regulator homolog 2 (E. coli) Q8WUX2 cytoplasm 40 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms CHAD HGNC:1909 chondroadherin O15335 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 1939097 secreted 96 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CHADL HGNC:25165 chondroadherin-like Q6NUI6 Secreted, extracellular space, extracellular matrix (By similarity). secreted 28 0 secreted secreted Chordata Chordata Cell.Organisms CHAF1A HGNC:1910 chromatin assembly factor 1, subunit A (p150) Q13111 Nucleus. Note=DNA replication foci. Nucleus (GO:0005634) 7600578,15143166,17081983 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa CHAF1B HGNC:1911 chromatin assembly factor 1, subunit B (p60) Q13112 Nucleus. Cytoplasm. Note=DNA replication foci. Cytoplasmic in M phase. Nucleus (GO:0005634) 7600578 nucleus 21 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CHAMP1 HGNC:20311 chromosome alignment maintaining phosphoprotein 1 Q96JM3 Nucleus. Chromosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 20 0 cytoplasm. nucleus multiple Amniota Amniota NA CHAT HGNC:1912 choline O-acetyltransferase P28329 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12637523,10861222,12637523,10861222 mitochondrion membrane 17 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms CHCHD1 HGNC:23518 coiled-coil-helix-coiled-coil-helix domain containing 1 Q96BP2 Nucleus. Nucleus (GO:0005634) 15177562 nucleus 67 0 nucleus nucleus Euteleostomi Bilateria Metazoa CHCHD10 HGNC:15559 coiled-coil-helix-coiled-coil-helix domain containing 10 Q8WYQ3 Mitochondrion (Potential). mitochondrion 52 0 mitochondrion mitochondrion NA NA Holozoa CHCHD2 HGNC:21645 coiled-coil-helix-coiled-coil-helix domain containing 2 Q9Y6H1 Mitochondrion (By similarity). mitochondrion 83 0 mitochondrion mitochondrion Opisthokonta Opisthokonta Opisthokonta CHCHD3 HGNC:21906 coiled-coil-helix-coiled-coil-helix domain containing 3 Q9NX63 Mitochondrion inner membrane; Lipid-anchor; Intermembrane side (By similarity). Cytoplasm. Nucleus. mitochondrion 84 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa CHCHD4 HGNC:26467 coiled-coil-helix-coiled-coil-helix domain containing 4 Q8N4Q1 Mitochondrion intermembrane space. mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota CHCHD5 HGNC:17840 coiled-coil-helix-coiled-coil-helix domain containing 5 Q9BSY4 Mitochondrion intermembrane space (Potential). secreted 63 0 secreted secreted Tetrapoda Tetrapoda Opisthokonta CHCHD6 HGNC:28184 coiled-coil-helix-coiled-coil-helix domain containing 6 Q9BRQ6 Mitochondrion inner membrane; Lipid-anchor (Probable). cytoplasm 10 0 cytoplasm cytoplasm Eutheria Euteleostomi Metazoa CHCHD7 HGNC:28314 coiled-coil-helix-coiled-coil-helix domain containing 7 Q9BUK0 Mitochondrion intermembrane space (Potential). mitochondrion 19 0 mitochondrion mitochondrion Tetrapoda Bilateria Opisthokonta CHD1 HGNC:1915 chromodomain helicase DNA binding protein 1 O14646 Nucleus. Cytoplasm (By similarity). Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12890497,7739555,7739555 nucleus 87 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CHD1L HGNC:1916 chromodomain helicase DNA binding protein 1-like Q86WJ1 Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Cell.Organisms NA CHD2 HGNC:1917 chromodomain helicase DNA binding protein 2 O14647 Nucleus (By similarity). Nucleus (GO:0005634) ,17000644 nucleus 56 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms CHD3 HGNC:1918 chromodomain helicase DNA binding protein 3 Q12873 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase and mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 7575689,19059367,15635413,15598749,17081983 nucleus 47 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CHD4 HGNC:1919 chromodomain helicase DNA binding protein 4 Q14839 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9804427,15635413,11790298,15598749/17081983,17081983 nucleus 49 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CHD5 HGNC:16816 chromodomain helicase DNA binding protein 5 Q8TDI0 Nucleus (By similarity). Nucleus (GO:0005634) none,19059367 nucleus 48 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CHD6 HGNC:19057 chromodomain helicase DNA binding protein 6 Q8TD26 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/ nucleus 59 3 nucleus nucleus Chordata Eukaryota Cell.Organisms CHD7 HGNC:20626 chromodomain helicase DNA binding protein 7 Q9P2D1 Isoform 1: Nucleus. Isoform 3: Nucleus, nucleolus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Chordata Eukaryota Cell.Organisms CHD8 HGNC:20153 chromodomain helicase DNA binding protein 8 Q9HCK8 Nucleus. Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17000644,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms CHD9 HGNC:25701 chromodomain helicase DNA binding protein 9 Q3L8U1 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16095617,16095617 nucleus 61 1 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms CHDC2 HGNC:26708 calponin homology domain containing 2 Q8N9S7 Membrane; Single-pass membrane protein (Potential). nucleus 45 1 nucleus nucleus Tetrapoda Deuterostomia Eukaryota CHDH HGNC:24288 choline dehydrogenase Q8NE62 Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739) secreted 23 0 secreted secreted Eukaryota Cell.Organisms Cell.Organisms CHEK1 HGNC:1925 checkpoint kinase 1 O14757 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B. Nucleus (GO:0005634) 9278511,14759516 nucleus 36 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms CHEK2 HGNC:16627 checkpoint kinase 2 O96017 Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53. Nucleus (GO:0005634); Centrosome (GO:0005813); Cytoplasm (GO:0005737) 10744722,12909615,12493754,12909615 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms CHERP HGNC:16930 calcium homeostasis endoplasmic reticulum protein Q8IWX8 Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. Cytoplasm (GO:0005737); Endoplasmic reticulum membrane (GO:0005789); Perinuclear region (GO:0048471) 10794731,12656674,12656674,12656674 nucleus 34 0 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Bilateria Eukaryota CHFR HGNC:20455 checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase Q96EP1 Nucleus, PML body. Nucleus (GO:0005634) 15467728 nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms CHGA HGNC:1929 chromogranin A (parathyroid secretory protein 1) P10645 Cytoplasmic vesicle, secretory vesicle lumen (By similarity). Cytoplasmic vesicle, secretory vesicle membrane (By similarity). Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 2445752,8096340,16199891 endoplasmic reticulum 25 0 endoplasmic reticulum. secreted multiple Tetrapoda Tetrapoda Euteleostomi CHGB HGNC:1930 chromogranin B (secretogranin 1) P05060 Secreted. Note=Neuroendocrine and endocrine secretory granules. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 7891024,1882087,3608978,12091348,16199891,12091348,14506248,11854265 secreted 100 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Amniota Amniota Tetrapoda CHI3L1 HGNC:1932 chitinase 3-like 1 (cartilage glycoprotein-39) P36222 Secreted, extracellular space. Extracellular (GO:0005576) 8245017 secreted 100 0 secreted secreted Mammalia Mammalia Cell.Organisms CHI3L2 HGNC:1933 chitinase 3-like 2 Q15782 Secreted (Potential). Extracellular (GO:0005576) 8702629 secreted 40 0 secreted secreted Catarrhini Theria Cell.Organisms CHIA HGNC:17432 chitinase, acidic Q9BZP6 Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12971947,10548734,12971947 secreted 60 0 cytoplasm. secreted multiple Chordata Cell.Organisms Cell.Organisms CHIC1 HGNC:1934 cysteine-rich hydrophobic domain 1 Q5VXU3 Cell membrane (By similarity). Cytoplasmic vesicle (By similarity). Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles (By similarity). Membrane fraction (GO:0005624); Cytosol (GO:0005829) 11257495,11257495 nucleus 67 1 cytoplasm cytoplasm Bilateria Bilateria Metazoa CHIC2 HGNC:1935 cysteine-rich hydrophobic domain 2 Q9UKJ5 Cell membrane. Cytoplasmic vesicle. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 11257495,11257495 nucleus 24 1 golgi apparatus. plasma membrane multiple Bilateria Bilateria Metazoa CHID1 HGNC:28474 chitinase domain containing 1 Q9BWS9 Secreted. Lysosome. Lysosome (GO:0005764); Late endosome (GO:0005770); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16357325,16357325,16357325,16357325,16357325 secreted 18 0 cytoplasm. endosome. golgi apparatus. lysosome. nucleus. secreted multiple Bilateria Cell.Organisms Cell.Organisms CHIT1 HGNC:1936 chitinase 1 (chitotriosidase) Q13231 Secreted. Lysosome. Note=A small proportion is lysosomal. Extracellular (GO:0005576) 7836450,7592832 secreted 42 0 lysosome. secreted multiple Chordata Cell.Organisms Cell.Organisms CHKA HGNC:1937 choline kinase alpha P35790 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota CHKB HGNC:1938 choline kinase beta Q9Y259 cytoplasm 56 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms CHL1 HGNC:1939 cell adhesion molecule L1-like O00533 Cell membrane; Single-pass type I membrane protein (By similarity). Processed neural cell adhesion molecule L1- like protein: Secreted, extracellular space, extracellular matrix (By similarity). Plasma membrane (GO:0005886) 9799093 plasma membrane 36 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms CHM HGNC:1940 choroideremia (Rab escort protein 1) P24386 Cytoplasm (GO:0005737) 11297488 cytoplasm 21 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota CHML HGNC:1941 choroideremia-like (Rab escort protein 2) P26374 Cytoplasm (GO:0005737) 11056004,7592656 cytoplasm 21 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota CHMP1A HGNC:8740 charged multivesicular body protein 1A Q9HD42 Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin. nucleus 55 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CHMP1B HGNC:24287 charged multivesicular body protein 1B Q7LBR1 Cytoplasm, cytosol. Endosome. Late endosome membrane; Peripheral membrane protein (Probable). Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body. Endosome (GO:0005768) nucleus 56 0 cytoplasm. endosome multiple NA NA Eukaryota CHMP2A HGNC:30216 charged multivesicular body protein 2A O43633 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15173323,15173323 nucleus 8 0 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota CHMP2B HGNC:24537 charged multivesicular body protein 2B Q9UQN3 Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein (Probable). nucleus 48 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota CHMP3 HGNC:29865 charged multivesicular body protein 3 Q9Y3E7 Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane (Probable). Note=Localizes to the midbody of dividing cells. Cytoplasm (GO:0005737); Endosome (GO:0005768); Nucleus (GO:0005634) 12878588,12878588,12878588,11549700 nucleus 64 0 cytoplasm. endosome. nucleus multiple Eukaryota Eukaryota Eukaryota CHMP4A HGNC:20274 charged multivesicular body protein 4A Q9BY43 Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein (Probable). Note=Membrane- associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Cytoplasmic vesicle (GO:0016023); Endosome (GO:0005768); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 12860994,14583093,14583093,14583093,12860994 cytoplasm 7 0 cytoplasm. endosome. lysosome multiple Homininae Theria Eukaryota CHMP4B HGNC:16171 charged multivesicular body protein 4B Q9H444 Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein (Probable). Cytoplasm (GO:0005737) 12860994,15511219 cytoplasm 7 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CHMP4C HGNC:30599 charged multivesicular body protein 4C Q96CF2 Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein (Probable). cytoplasm 9 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota CHMP5 HGNC:26942 charged multivesicular body protein 5 Q9NZZ3 Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein (Probable). Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. cytoplasm 8 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CHMP6 HGNC:25675 charged multivesicular body protein 6 Q96FZ7 Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane (Probable). Note=Localizes to endosomal membranes. cytoplasm 0 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CHMP7 HGNC:28439 charged multivesicular body protein 7 Q8WUX9 Cytoplasm. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota CHN1 HGNC:1943 chimerin 1 P15882 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Microsome (GO:0005792) 11438594,15013773,11438594,15013773,11438594 cytoplasm 34 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CHN2 HGNC:1944 chimerin 2 P52757 Membrane; Peripheral membrane protein (Potential). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Perinuclear region (GO:0048471) 11278894,11278894,16628218,11278894,11278894,16628218 cytoplasm 27 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota CHODL HGNC:17807 chondrolectin Q9H9P2 Cytoplasm. Membrane; Single-pass type I membrane protein (Potential). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12079284,12079284 secreted 23 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Holozoa CHORDC1 HGNC:14525 cysteine and histidine-rich domain (CHORD) containing 1 Q9UHD1 secreted 68 0 secreted secreted Bilateria Eukaryota Eukaryota CHP1 HGNC:17433 calcineurin-like EF-hand protein 1 Q99653 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Endoplasmic reticulum (By similarity). Cell membrane. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH- independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1/NHE1 at the reticulum endoplasmic. Colocalizes with STK17B at the plasma membrane (By similarity). Colocalizes with SLC9A1/NHE1 at the cell membrane. cytoplasm 31 0 cytoplasm cytoplasm NA NA Cell.Organisms CHP2 HGNC:24927 calcineurin-like EF-hand protein 2 O43745 Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. cytoplasm 29 0 cytoplasm. nucleus multiple NA NA Cell.Organisms CHPF HGNC:24291 chondroitin polymerizing factor Q8IZ52 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). endoplasmic reticulum membrane 7 0 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Holozoa CHPF2 HGNC:29270 chondroitin polymerizing factor 2 Q9P2E5 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) 12145278 endoplasmic reticulum membrane 8 0 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Holozoa CHPT1 HGNC:17852 choline phosphotransferase 1 Q8WUD6 Golgi apparatus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Microsome (GO:0005792) 10893425,10893425 golgi apparatus membrane 100 10 golgi apparatus membrane golgi apparatus membrane Mammalia Tetrapoda Cell.Organisms CHRAC1 HGNC:13544 chromatin accessibility complex 1 Q9NRG0 Nucleus (Potential). Nucleus (GO:0005634) 10880450 nucleus 22 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota CHRD HGNC:1949 chordin Q9H2X0 Secreted (By similarity). Extracellular (GO:0005576) 9782094 secreted 20 0 secreted secreted Deuterostomia Bilateria Eumetazoa CHRDL1 HGNC:29861 chordin-like 1 Q9BU40 Secreted (Potential). secreted 78 0 secreted secreted Deuterostomia Deuterostomia Metazoa CHRDL2 HGNC:24168 chordin-like 2 Q6WN34 Isoform 1: Secreted (Potential). Isoform 2: Secreted (Potential). Isoform 3: Cytoplasm (Potential). Isoform 4: Cytoplasm (Potential). Isoform 5: Cytoplasm (Potential). Extracellular (GO:0005576) 15094188 secreted 27 0 secreted secreted Amniota Euteleostomi Metazoa CHRFAM7A HGNC:15781 CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion Q494W8 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 13 4 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa CHRM1 HGNC:1950 cholinergic receptor, muscarinic 1 P11229 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Theria Tetrapoda Metazoa CHRM2 HGNC:1951 cholinergic receptor, muscarinic 2 P08172 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Early endosome (GO:0005769) 8576254,12093817 plasma membrane 22 7 endosome. plasma membrane multiple Deuterostomia Deuterostomia Eumetazoa CHRM3 HGNC:1952 cholinergic receptor, muscarinic 3 P20309 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8576254 plasma membrane 22 7 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa CHRM4 HGNC:1953 cholinergic receptor, muscarinic 4 P08173 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8576254 plasma membrane 19 7 plasma membrane plasma membrane Human Euteleostomi Eumetazoa CHRM5 HGNC:1954 cholinergic receptor, muscarinic 5 P08912 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8576254 plasma membrane 20 7 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa CHRNA1 HGNC:1955 cholinergic receptor, nicotinic, alpha 1 (muscle) P02708 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9158151 plasma membrane 8 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CHRNA10 HGNC:13800 cholinergic receptor, nicotinic, alpha 10 (neuronal) Q9GZZ6 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell membrane; Multi-pass membrane protein (Probable). plasma membrane 15 4 plasma membrane plasma membrane Euarchontoglires Deuterostomia Cell.Organisms CHRNA2 HGNC:1956 cholinergic receptor, nicotinic, alpha 2 (neuronal) Q15822 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9193799,12783266 plasma membrane 17 4 plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms CHRNA3 HGNC:1957 cholinergic receptor, nicotinic, alpha 3 (neuronal) P32297 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10336173,9387186,7490471 plasma membrane 19 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms CHRNA4 HGNC:1958 cholinergic receptor, nicotinic, alpha 4 (neuronal) P43681 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor (By similarity). Plasma membrane (GO:0005886) 7721089 plasma membrane 17 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms CHRNA5 HGNC:1959 cholinergic receptor, nicotinic, alpha 5 (neuronal) P30532 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9193799,12783266 plasma membrane 11 4 plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms CHRNA6 HGNC:15963 cholinergic receptor, nicotinic, alpha 6 (neuronal) Q15825 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,8950106 plasma membrane 19 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms CHRNA7 HGNC:1960 cholinergic receptor, nicotinic, alpha 7 (neuronal) P36544 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7571003,9193799,12783266 plasma membrane 15 4 plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms CHRNA9 HGNC:14079 cholinergic receptor, nicotinic, alpha 9 (neuronal) Q9UGM1 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) plasma membrane 17 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms CHRNB1 HGNC:1961 cholinergic receptor, nicotinic, beta 1 (muscle) P11230 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 887246 plasma membrane 12 4 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa CHRNB2 HGNC:1962 cholinergic receptor, nicotinic, beta 2 (neuronal) P17787 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10771020 plasma membrane 16 4 plasma membrane plasma membrane Chordata Chordata Cell.Organisms CHRNB3 HGNC:1963 cholinergic receptor, nicotinic, beta 3 (neuronal) Q05901 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7571003,9193799,12783266 plasma membrane 13 4 plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms CHRNB4 HGNC:1964 cholinergic receptor, nicotinic, beta 4 (neuronal) P30926 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9193799,7571003,12783266 plasma membrane 15 4 plasma membrane. secreted multiple Chordata Chordata Cell.Organisms CHRND HGNC:1965 cholinergic receptor, nicotinic, delta (muscle) Q07001 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 12 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CHRNE HGNC:1966 cholinergic receptor, nicotinic, epsilon (muscle) Q04844 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9158150 plasma membrane 10 4 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms CHRNG HGNC:1967 cholinergic receptor, nicotinic, gamma (muscle) P07510 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 3967651 plasma membrane 14 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms CHST1 HGNC:1969 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 O43916 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 23 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Eumetazoa CHST10 HGNC:19650 carbohydrate sulfotransferase 10 O43529 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) secreted 59 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CHST11 HGNC:17422 carbohydrate (chondroitin 4) sulfotransferase 11 Q9NPF2 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 10781601 secreted 62 0 golgi apparatus golgi apparatus Euteleostomi Bilateria Cell.Organisms CHST12 HGNC:17423 carbohydrate (chondroitin 4) sulfotransferase 12 Q9NRB3 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 10781601 mitochondrion membrane 19 1 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Metazoa CHST13 HGNC:21755 carbohydrate (chondroitin 4) sulfotransferase 13 Q8NET6 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 10781601 secreted 41 0 golgi apparatus golgi apparatus Human Bilateria Metazoa CHST14 HGNC:24464 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 Q8NCH0 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) 11470797 secreted 14 1 secreted secreted Eutheria Deuterostomia Cell.Organisms CHST15 HGNC:18137 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 Q7LFX5 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor. Integral to membrane (GO:0016021); Microsome (GO:0005792) 10749872,10749872 secreted 7 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Eukaryota Cell.Organisms CHST2 HGNC:1970 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 Q9Y4C5 Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein (Probable). Golgi apparatus (GO:0005794) 12855678 golgi apparatus membrane 24 1 golgi apparatus. golgi apparatus membrane multiple Theria Deuterostomia Eumetazoa CHST3 HGNC:1971 carbohydrate (chondroitin 6) sulfotransferase 3 Q7LGC8 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 18 1 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi Cell.Organisms CHST4 HGNC:1972 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 Q8NCG5 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 11181564 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Amniota Amniota Cell.Organisms CHST5 HGNC:1973 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 Q9GZS9 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Note=Golgi membrane, early secretory pathway. Integral to membrane (GO:0016021) 10491328 golgi apparatus membrane 48 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eumetazoa CHST6 HGNC:6938 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 Q9GZX3 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 11087716 golgi apparatus membrane 48 0 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Eumetazoa CHST7 HGNC:13817 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 Q9NS84 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 10956661 golgi apparatus membrane 29 0 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi Eumetazoa CHST8 HGNC:15993 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 Q9H2A9 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). endoplasmic reticulum membrane 12 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Cell.Organisms CHST9 HGNC:19898 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 Q7L1S5 Isoform 1: Golgi apparatus membrane; Single- pass type II membrane protein (By similarity). Isoform 2: Secreted (Probable). Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021) 11445554,11139592,11139592,11445554 mitochondrion membrane 8 0 golgi apparatus. secreted multiple Amniota Chordata Cell.Organisms CHSY1 HGNC:17198 chondroitin sulfate synthase 1 Q86X52 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Secreted. Golgi apparatus (GO:0005794) 11514575 endoplasmic reticulum membrane 11 0 golgi apparatus. golgi apparatus membrane. secreted multiple Bilateria Bilateria Eukaryota CHSY3 HGNC:24293 chondroitin sulfate synthase 3 Q70JA7 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021); Nucleus (GO:0005634) 12907687,17081983 secreted 16 0 golgi apparatus membrane. nucleus multiple Bilateria Bilateria Cell.Organisms CHTF18 HGNC:18435 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) Q8WVB6 Nucleus. Note=Associates with chromatin during S phase. Nucleus (GO:0005634) 12766176 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms CHTF8 HGNC:24353 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) P0CG12 Nucleus. Nucleus (GO:0005634) 12766176 nucleus 100 0 nucleus nucleus Theria Theria Eukaryota CHTOP HGNC:24511 chromatin target of PRMT1 Q9Y3Y2 Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Note=Mostly associated with facultative heterochromatin (By similarity). Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Chordata Chordata Eumetazoa CHUK HGNC:1974 conserved helix-loop-helix ubiquitous kinase O15111 Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytosol (GO:0005829) 9252186,11864612,,17891179,,,17891179, cytoplasm 14 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms CHURC1 HGNC:20099 churchill domain containing 1 Q8WUH1 Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus NA NA Holozoa CIAO1 HGNC:14280 cytosolic iron-sulfur assembly component 1 O76071 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9556563,9556563 cytoplasm 15 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CIAPIN1 HGNC:28050 cytokine induced apoptosis inhibitor 1 Q6FI81 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 14970183 nucleus 32 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CIART HGNC:25200 circadian associated repressor of transcription Q8N365 nucleus 83 0 nucleus nucleus Theria Euteleostomi NA CIB1 HGNC:16920 calcium and integrin binding 1 (calmyrin) Q99828 Membrane; Lipid-anchor. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane. Note=Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10366599,15190070,10366599,10366599,10366599 cytoplasm 22 0 cytoplasm. endoplasmic reticulum. nucleus multiple Deuterostomia Eukaryota Eukaryota CIB2 HGNC:24579 calcium and integrin binding family member 2 O75838 Photoreceptor inner segment (By similarity). Note=Expressed in inner and outer segments of photoreceptor cells, as well as in the pigmented epithelium. Also observed in the inner and outer plexiform layers and in the ganglion cell layer (By similarity). Nucleus (GO:0005634) 9891849 cytoplasm 20 0 nucleus nucleus Theria Bilateria Eukaryota CIB3 HGNC:24580 calcium and integrin binding family member 3 Q96Q77 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CIB4 HGNC:33703 calcium and integrin binding family member 4 A0PJX0 cytoplasm 10 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota CIC HGNC:14214 capicua transcriptional repressor Q96RK0 Nucleus (Potential). Nucleus (GO:0005634); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,19059367,17081983 nucleus 28 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eukaryota CIDEA HGNC:1976 cell death-inducing DFFA-like effector a O60543 Lipid droplet. Nucleus (By similarity). Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). cytoplasm 37 0 lipid droplet lipid droplet Tetrapoda Euteleostomi Eumetazoa CIDEB HGNC:1977 cell death-inducing DFFA-like effector b Q9UHD4 Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10837461,10837461,10837461 cytoplasm 20 0 cytoplasm. mitochondrion. nucleus multiple Theria Euteleostomi Eumetazoa CIDEC HGNC:24229 cell death-inducing DFFA-like effector c Q96AQ7 Nucleus (By similarity). Endoplasmic reticulum (By similarity). Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites. Cytoplasm (GO:0005737) 12429024 cytoplasm 26 0 cytoplasm. lipid droplet multiple Theria Euteleostomi Eumetazoa CIITA HGNC:7067 class II, major histocompatibility complex, transactivator P33076 Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML. Nucleus (GO:0005634) 1007865 nucleus 100 1 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms CILP HGNC:1980 cartilage intermediate layer protein, nucleotide pyrophosphohydrolase O75339 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 9722584 secreted 100 0 secreted secreted Chordata Chordata Bilateria CILP2 HGNC:24213 cartilage intermediate layer protein 2 Q8IUL8 Secreted, extracellular space, extracellular matrix (By similarity). secreted 40 0 secreted secreted Chordata Chordata Bilateria CINP HGNC:23789 cyclin-dependent kinase 2 interacting protein Q9BW66 Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication. nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Metazoa CIPC HGNC:20365 CLOCK-interacting pacemaker Q9C0C6 nucleus 87 0 nucleus nucleus Euteleostomi Euteleostomi Craniata CIR1 HGNC:24217 corepressor interacting with RBPJ, 1 Q86X95 Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Co-localizes with NEK6 in the centrosome. Nucleus (GO:0005634) 9874765,17081983 nucleus 16 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CIRBP HGNC:1982 cold inducible RNA binding protein Q14011 Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). Nucleus (GO:0005634) 12819390 nucleus 37 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms CIRH1A HGNC:1983 cirrhosis, autosomal recessive 1A (cirhin) Q969X6 Nucleus, nucleolus. Mitochondrion (GO:0005739); Nucleolus (GO:0005730); Cytosol (GO:0005829) 12417987,15635413,15561729 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota NA CISD1 HGNC:30880 CDGSH iron sulfur domain 1 Q9NZ45 Mitochondrion outer membrane; Single-pass type III membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Euteleostomi Eukaryota Eukaryota CISD2 HGNC:24212 CDGSH iron sulfur domain 2 Q8N5K1 Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane. Integral to membrane (GO:0016021) mitochondrion membrane 45 1 endoplasmic reticulum membrane. mitochondrion membrane multiple Human Human Eukaryota CISD3 HGNC:27578 CDGSH iron sulfur domain 3 P0C7P0 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion NA NA Cell.Organisms CISH HGNC:1984 cytokine inducible SH2-containing protein Q9NSE2 nucleus 25 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa CIT HGNC:1985 citron (rho-interacting, serine/threonine kinase 21) O14578 Cytoplasm (By similarity). Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9792683/17081983,17081983 cytoplasm 96 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms CITED1 HGNC:1986 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 Q99966 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner. Nucleus (GO:0005634) 9434189,8901575,11310794,9683535,9721210 nucleus 62 0 cytoplasm. nucleus multiple Euarchontoglires Mammalia Chordata CITED2 HGNC:1987 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 Q99967 Nucleus. Note=Colocalizes with EP300 in dot- like structures. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10552932,9434189,12586840 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Chordata CITED4 HGNC:18696 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 Q96RK1 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11744733,11744733 nucleus 33 0 cytoplasm. nucleus multiple Human Human Euteleostomi CIZ1 HGNC:16744 CDKN1A interacting zinc finger protein 1 Q9ULV3 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10529385,12824700,15585571,10529385 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Bilateria Bilateria CKAP2 HGNC:1990 cytoskeleton associated protein 2 Q8WWK9 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules. Cytoskeleton (GO:0005856); Microtubule (GO:0005874) 9771967,15561729 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eumetazoa CKAP2L HGNC:26877 cytoskeleton associated protein 2-like Q8IYA6 Nucleus (GO:0005634) 15561729 cytoplasm 20 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa CKAP4 HGNC:16991 cytoskeleton-associated protein 4 Q07065 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF- stimulation. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytoskeleton (GO:0005856) 12913003,1730740,7673362,7673362,1730740,15561729 nucleus 13 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota CKAP5 HGNC:28959 cytoskeleton associated protein 5 Q14008 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during mitosis. Centrosome (GO:0005813); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 12569123,14603251,12569123,15561729,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Eukaryota CKB HGNC:1991 creatine kinase, brain P12277 Cytoplasm. Cytoplasm (GO:0005737) 12039490 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CKLF HGNC:13253 chemokine-like factor Q9UBR5 Isoform 1: Secreted. Isoform 2: Membrane; Multi-pass membrane protein (Potential). Isoform 4: Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11415443 plasma membrane 14 4 secreted secreted Mammalia Mammalia Euteleostomi CKM HGNC:1994 creatine kinase, muscle P06732 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12039490,16188874 cytoplasm 100 0 cytoplasm. secreted multiple Bilateria Eukaryota Cell.Organisms CKMT1A HGNC:31736 creatine kinase, mitochondrial 1A P12532 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion (GO:0005739) 2914937 cytoplasm 60 0 mitochondrion mitochondrion NA NA Cell.Organisms CKMT1B HGNC:1995 creatine kinase, mitochondrial 1B P12532 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion (GO:0005739) 10737943 cytoplasm 60 0 mitochondrion mitochondrion NA NA Cell.Organisms CKMT2 HGNC:1996 creatine kinase, mitochondrial 2 (sarcomeric) P17540 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 12401781,16188874 cytoplasm 61 0 mitochondrion. secreted multiple Deuterostomia Cell.Organisms Cell.Organisms CKS1B HGNC:19083 CDC28 protein kinase regulatory subunit 1B P61024 Mitochondrion (GO:0005739) 15598749 nucleus 18 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota CKS2 HGNC:2000 CDC28 protein kinase regulatory subunit 2 P33552 nucleus 17 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CLASP1 HGNC:17088 cytoplasmic linker associated protein 1 Q7Z460 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network (Probable). Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 12837247,12837247,17081983,12837247,17081983,15561729 cytoplasm 14 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota CLASP2 HGNC:17078 cytoplasmic linker associated protein 2 O75122 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Microtubule (GO:0005874) 15631994,15631994,15561729 cytoplasm 4 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota CLASRP HGNC:17731 CLK4-associating serine/arginine rich protein Q8N2M8 Nucleus (By similarity). Nucleus (GO:0005634) 12169693,17081983 nucleus 91 0 nucleus nucleus Theria Bilateria Eukaryota CLC HGNC:2014 Charcot-Leyden crystal galectin Q05315 Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634); Secretory granule (GO:0030141) 8419478,2160562,8419478,2160563,2160562,1373430,8419478,2160562,1373430,8419478,2160563,2160562,1373430,2160562,1373430,2709814 nucleus 38 0 cytoplasm. nucleus. secreted multiple Theria Theria Bilateria CLCA1 HGNC:2015 chloride channel accessory 1 A8K7I4 Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli. Plasma membrane (GO:0005886) 9828122 secreted 70 1 plasma membrane. secreted multiple Deuterostomia Bilateria Cell.Organisms CLCA2 HGNC:2016 chloride channel accessory 2 Q9UQC9 Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction. Calcium-activated chloride channel regulator 2, 109 kDa form: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release. Plasma membrane (GO:0005886) 10362588 secreted 47 1 plasma membrane. secreted multiple Deuterostomia Bilateria Cell.Organisms CLCA4 HGNC:2018 chloride channel accessory 4 Q14CN2 Cell membrane; Single-pass membrane protein (By similarity). Apical cell membrane (By similarity). Secreted (By similarity). Note=The C-terminus 30 kDa form is anchored to the membrane (By similarity). The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus (By similarity). secreted 49 1 secreted secreted Deuterostomia Bilateria Cell.Organisms CLCC1 HGNC:29675 chloride channel CLIC-like 1 Q96S66 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum. Golgi apparatus. Nucleus (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 11279057,11279057,11279057 secreted 55 3 endoplasmic reticulum. golgi apparatus. nucleus multiple Tetrapoda Deuterostomia Eumetazoa CLCF1 HGNC:17412 cardiotrophin-like cytokine factor 1 Q9UBD9 Secreted (By similarity). Extracellular (GO:0005576) 10448081 cytoplasm 36 0 secreted secreted Euarchontoglires Euteleostomi Euteleostomi CLCN1 HGNC:2019 chloride channel, voltage-sensitive 1 P35523 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9122265,10690989 plasma membrane 32 13 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms CLCN2 HGNC:2020 chloride channel, voltage-sensitive 2 P51788 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11976342 plasma membrane 36 13 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms CLCN3 HGNC:2021 chloride channel, voltage-sensitive 3 P51790 Isoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein (By similarity). Isoform 2: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi. Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasmic vesicle (GO:0016023);Endosome (GO:0005768);Golgi apparatus (GO:0005794) 11306429,12843258,11274166,12471024,11274166/12471024/12471024 plasma membrane 13 12 endosome. endosome membrane. golgi apparatus. golgi apparatus membrane. plasma membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms CLCN4 HGNC:2022 chloride channel, voltage-sensitive 4 P51793 Early endosome membrane; Multi-pass membrane protein (By similarity). Late endosome membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10564087,16034421 plasma membrane 14 12 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms CLCN5 HGNC:2023 chloride channel, voltage-sensitive 5 P51795 Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737) 9931332,16034421,9931332,12904289 plasma membrane 15 12 cytoplasm. endosome. endosome membrane. golgi apparatus membrane. plasma membrane multiple Cell.Organisms Cell.Organisms NA CLCN6 HGNC:2024 chloride channel, voltage-sensitive 6 P51797 Endosome membrane; Multi-pass membrane protein. Note=Detected in detergent-resistant lipid rafts. Plasma membrane (GO:0005886) 10198195,9224655 mitochondrion 13 14 endosome membrane. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms CLCN7 HGNC:2025 chloride channel, voltage-sensitive 7 P51798 Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768); Lysosome (GO:0005764) 11207362,11207362,11207362 plasma membrane 9 14 endosome. lysosome. lysosome membrane. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms CLCNKA HGNC:2026 chloride channel, voltage-sensitive Ka P51800 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8812470,17081983 plasma membrane 89 13 nucleus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms CLCNKB HGNC:2027 chloride channel, voltage-sensitive Kb P51801 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8812470 plasma membrane 100 13 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CLDN1 HGNC:2032 claudin 1 O95832 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9931503,11939410,11382769,9647647,12067061 plasma membrane 13 3 plasma membrane plasma membrane Chordata Chordata Olfactores CLDN10 HGNC:2033 claudin 10 P78369 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 14 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Olfactores CLDN11 HGNC:8514 claudin 11 O75508 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10612400 golgi apparatus membrane 75 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Olfactores CLDN12 HGNC:2034 claudin 12 P56749 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12475568,15068973,14698084,12067061,11912246,11585919 golgi apparatus membrane 76 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata CLDN14 HGNC:2035 claudin 14 O95500 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11163249,15880785,15880785 golgi apparatus membrane 73 3 cytoplasm. plasma membrane multiple Chordata Chordata Olfactores CLDN15 HGNC:2036 claudin 15 P56746 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12475568,12055082,13129853,11912246,11095601 plasma membrane 16 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Olfactores CLDN16 HGNC:2037 claudin 16 Q9Y5I7 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) golgi apparatus membrane 49 4 plasma membrane plasma membrane Tetrapoda Tetrapoda Olfactores CLDN17 HGNC:2038 claudin 17 P56750 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12067061 golgi apparatus membrane 71 4 plasma membrane plasma membrane Theria Amniota Olfactores CLDN18 HGNC:2039 claudin 18 P56856 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11585919 golgi apparatus membrane 75 3 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa CLDN19 HGNC:2040 claudin 19 Q8N6F1 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12231346 plasma membrane 15 3 plasma membrane plasma membrane Chordata Chordata Deuterostomia CLDN2 HGNC:2041 claudin 2 P57739 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9647647 golgi apparatus membrane 69 4 plasma membrane plasma membrane Tetrapoda Chordata Olfactores CLDN20 HGNC:2042 claudin 20 P56880 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1124737 golgi apparatus membrane 70 3 plasma membrane plasma membrane Amniota Euteleostomi Olfactores CLDN22 HGNC:2044 claudin 22 Q8N7P3 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 73 3 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Olfactores CLDN23 HGNC:17591 claudin 23 Q96B33 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) golgi apparatus membrane 82 3 golgi apparatus membrane golgi apparatus membrane NA NA Craniata CLDN24 HGNC:37200 claudin 24 A6NM45 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 74 4 golgi apparatus membrane golgi apparatus membrane Human Human Olfactores CLDN25 HGNC:37218 claudin 25 C9JDP6 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 72 3 golgi apparatus membrane golgi apparatus membrane NA NA Olfactores CLDN3 HGNC:2045 claudin 3 O15551 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9334247 golgi apparatus membrane 72 4 plasma membrane plasma membrane Euteleostomi Euteleostomi NA CLDN4 HGNC:2046 claudin 4 O14493 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9087440 golgi apparatus membrane 76 4 plasma membrane plasma membrane Euteleostomi Euteleostomi NA CLDN5 HGNC:2047 claudin 5 O00501 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9192844 golgi apparatus membrane 71 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Olfactores CLDN6 HGNC:2048 claudin 6 P56747 Cell junction, tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 12475568,12231346,15541721,15454572,15366020,12896909,12749857,12060405,12110008,11923212,11912246,11668606,10508865 golgi apparatus membrane 72 3 plasma membrane plasma membrane Theria Tetrapoda Olfactores CLDN7 HGNC:2049 claudin 7 O95471 Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction. Plasma membrane (GO:0005886) 12673207,11247307 golgi apparatus membrane 74 3 plasma membrane plasma membrane Theria Euteleostomi Deuterostomia CLDN8 HGNC:2050 claudin 8 P56748 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9892664,,17145811, golgi apparatus membrane 71 4 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Olfactores CLDN9 HGNC:2051 claudin 9 O95484 Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12475568,14698084,12742348,11912246,11095601 golgi apparatus membrane 76 4 plasma membrane plasma membrane Theria Theria Olfactores CLDND1 HGNC:1322 claudin domain containing 1 Q9NY35 Membrane; Multi-pass membrane protein (Potential). plasma membrane 15 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria CLDND2 HGNC:28511 claudin domain containing 2 Q8NHS1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 59 4 golgi apparatus membrane golgi apparatus membrane Eutheria Mammalia Euteleostomi CLEC10A HGNC:16916 C-type lectin domain family 10, member A Q8IUN9 Membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) 8598452 secreted 25 1 secreted secreted Eutheria Euteleostomi Cell.Organisms CLEC11A HGNC:10576 C-type lectin domain family 11, member A Q9Y240 Cytoplasm. Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9442024,11803813 plasma membrane 15 0 cytoplasm. secreted multiple Mammalia Euteleostomi Eumetazoa CLEC12A HGNC:31713 C-type lectin domain family 12, member A Q5QGZ9 Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization. Plasma membrane (GO:0005886) 14739280 plasma membrane 100 1 plasma membrane plasma membrane Amniota Amniota Eumetazoa CLEC12B HGNC:31966 C-type lectin domain family 12, member B Q2HXU8 Cell membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane NA NA Eumetazoa CLEC14A HGNC:19832 C-type lectin domain family 14, member A Q86T13 Membrane; Single-pass type I membrane protein (Potential). secreted 26 1 secreted secreted Eutheria Euteleostomi Craniata CLEC16A HGNC:29013 C-type lectin domain family 16, member A Q2KHT3 nucleus 67 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CLEC17A HGNC:34520 C-type lectin domain family 17, member A Q6ZS10 Membrane; Single-pass type II membrane protein (Potential). Note=In fibroblasts, expressed on the cell surface. Integral to membrane (GO:0016021) secreted 25 1 secreted secreted Catarrhini Mammalia Cell.Organisms CLEC18A HGNC:30388 C-type lectin domain family 18, member A A5D8T8 Secreted (Potential). Extracellular (GO:0005576) secreted 16 0 secreted secreted Amniota Euteleostomi Cell.Organisms CLEC18B HGNC:33849 C-type lectin domain family 18, member B Q6UXF7 Secreted (Potential). Extracellular (GO:0005576) secreted 16 0 secreted secreted Amniota Euteleostomi Cell.Organisms CLEC18C HGNC:28538 C-type lectin domain family 18, member C Q8NCF0 Secreted (Potential). vacuole 16 0 vacuole vacuole Amniota Euteleostomi Cell.Organisms CLEC19A HGNC:34522 C-type lectin domain family 19, member A Q6UXS0 Secreted (Potential). secreted 25 0 secreted secreted Amniota Deuterostomia Eumetazoa CLEC1A HGNC:24355 C-type lectin domain family 1, member A Q8NC01 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 10671229 plasma membrane 19 1 plasma membrane plasma membrane Theria Theria Eumetazoa CLEC1B HGNC:24356 C-type lectin domain family 1, member B Q9P126 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 10671229 plasma membrane 21 1 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa CLEC2A HGNC:24191 C-type lectin domain family 2, member A Q6UVW9 Cell membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Catarrhini Eumetazoa CLEC2B HGNC:2053 C-type lectin domain family 2, member B Q92478 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 9038101 plasma membrane 23 1 plasma membrane plasma membrane Tetrapoda Deuterostomia Eumetazoa CLEC2D HGNC:14351 C-type lectin domain family 2, member D Q9UHP7 Cell membrane; Single-pass type II membrane protein. Cell surface. Isoform 2: Endoplasmic reticulum. Isoform 4: Endoplasmic reticulum. Integral to membrane (GO:0016021) plasma membrane 34 1 endoplasmic reticulum. plasma membrane multiple Tetrapoda Deuterostomia Holozoa CLEC2L HGNC:21969 C-type lectin domain family 2, member L P0C7M8 Membrane; Single-pass membrane protein (Potential). plasma membrane 21 1 plasma membrane plasma membrane NA NA Eukaryota CLEC3A HGNC:2052 C-type lectin domain family 3, member A O75596 Secreted. Extracellular (GO:0005576) 10524194 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CLEC3B HGNC:11891 C-type lectin domain family 3, member B P05452 Secreted. Extracellular (GO:0005576) 7798325,10964919,16188874 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms CLEC4A HGNC:13257 C-type lectin domain family 4, member A Q9UMR7 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 10438934,14550269 secreted 17 1 plasma membrane plasma membrane Euarchontoglires Eutheria Cell.Organisms CLEC4C HGNC:13258 C-type lectin domain family 4, member C Q8WTT0 Membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) 11536172 secreted 19 1 secreted secreted Homininae Bilateria Cell.Organisms CLEC4D HGNC:14554 C-type lectin domain family 4, member D Q8WXI8 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 14971047 secreted 21 1 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms CLEC4E HGNC:14555 C-type lectin domain family 4, member E Q9ULY5 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 10528209 secreted 20 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms CLEC4F HGNC:25357 C-type lectin domain family 4, member F Q8N1N0 Membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 1846367 secreted 30 1 plasma membrane plasma membrane Theria Theria NA CLEC4G HGNC:24591 C-type lectin domain family 4, member G Q6UXB4 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 14711836 secreted 25 1 plasma membrane plasma membrane Eutheria Mammalia Holozoa CLEC4M HGNC:13523 C-type lectin domain family 4, member M Q9H2X3 Isoform 1: Cell membrane; Single-pass type II membrane protein (Potential). Isoform 2: Cell membrane; Single-pass type II membrane protein (Potential). Isoform 3: Cell membrane; Single-pass type II membrane protein (Potential). Isoform 5: Secreted (Potential). Isoform 6: Secreted (Potential). Isoform 7: Secreted (Potential). Isoform 10: Secreted (Potential). Integral to membrane (GO:0016021) 10975799 secreted 25 1 secreted secreted Euarchontoglires Euteleostomi Cell.Organisms CLEC5A HGNC:2054 C-type lectin domain family 5, member A Q9NY25 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 10449773 plasma membrane 100 1 plasma membrane plasma membrane NA NA NA CLEC6A HGNC:14556 C-type lectin domain family 6, member A Q6EIG7 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 15175046 secreted 15 1 plasma membrane plasma membrane Euarchontoglires Eutheria Cell.Organisms CLEC7A HGNC:14558 C-type lectin domain family 7, member A Q9BXN2 Cell membrane; Single-pass type II membrane protein. Isoform 5: Cytoplasm. Isoform 6: Cytoplasm (Probable). Isoform 7: Cytoplasm (Probable). Integral to membrane (GO:0016021) 11470510 plasma membrane 50 1 cytoplasm. plasma membrane multiple Eutheria Mammalia Eukaryota CLEC9A HGNC:26705 C-type lectin domain family 9, member A Q6UXN8 Membrane; Single-pass type II membrane protein. plasma membrane 15 1 plasma membrane plasma membrane Eutheria Mammalia Eumetazoa CLECL1 HGNC:24462 C-type lectin-like 1 Q8IZS7 Cell membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Catarrhini Euteleostomi CLGN HGNC:2060 calmegin O14967 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11784061,10495883,17081983 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Eukaryota Cell.Organisms CLHC1 HGNC:26453 clathrin heavy chain linker domain containing 1 Q8NHS4 nucleus 56 0 nucleus nucleus Mammalia Deuterostomia Eukaryota CLIC1 HGNC:2062 chloride intracellular channel 1 O00299 Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell membrane; Single-pass membrane protein (Probable). Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9841507,9139710,9841507 mitochondrion 12 0 cytoplasm. nucleus. nucleus membrane. plasma membrane multiple Theria Eukaryota NA CLIC2 HGNC:2063 chloride intracellular channel 2 O15247 Cytoplasm. Membrane; Single-pass membrane protein (Probable). Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Plasma membrane (GO:0005886) 1311421 mitochondrion 16 0 cytoplasm cytoplasm Bilateria Eukaryota NA CLIC3 HGNC:2064 chloride intracellular channel 3 O95833 Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Nucleus (GO:0005634) 9880541 mitochondrion 10 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms CLIC4 HGNC:13518 chloride intracellular channel 4 Q9Y696 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein (Probable). Nucleus matrix. Cell membrane; Single-pass membrane protein (Probable). Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10793131,10793131 mitochondrion 12 0 cytoplasm. mitochondrion. nucleus. plasma membrane multiple Theria Euteleostomi Cell.Organisms CLIC5 HGNC:13517 chloride intracellular channel 5 Q9NZA1 Isoform 1: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Single-pass membrane protein. Isoform 2: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Single-pass membrane protein. Note=Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). Colocalized with podocalyxin in renal glomeruli. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10793131,10793131 mitochondrion 14 0 cytoplasm. golgi apparatus multiple Euteleostomi Euteleostomi Cell.Organisms CLIC6 HGNC:2065 chloride intracellular channel 6 Q96NY7 Cytoplasm (By similarity). Cell membrane; Single-pass membrane protein (By similarity). Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023) 14597386,14597386,14597386 mitochondrion 17 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms CLINT1 HGNC:23186 clathrin interactor 1 Q14677 Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 17081983,17081983/12429846,12213833 cytoplasm 15 0 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Eukaryota CLIP1 HGNC:10461 CAP-GLY domain containing linker protein 1 P30622 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles. Endosome (GO:0005768); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737);Microtubule (GO:0005874); Kinetochore (GO:0000776) 1356075,7983157/17081983/10052454,16362039,15561729,16362039 cytoplasm 24 0 cytoplasm. endosome multiple Deuterostomia Opisthokonta Eukaryota CLIP2 HGNC:2586 CAP-GLY domain containing linker protein 2 Q9UDT6 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the cytoskeleton (By similarity). Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983/ cytoplasm 21 0 cytoplasm cytoplasm Deuterostomia Opisthokonta NA CLIP3 HGNC:24314 CAP-GLY domain containing linker protein 3 Q96DZ5 Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11854307,11854307,11854307 cytoplasm 26 0 cytoplasm. golgi apparatus multiple Euteleostomi Euteleostomi Eukaryota CLIP4 HGNC:26108 CAP-GLY domain containing linker protein family, member 4 Q8N3C7 nucleus 29 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms CLK1 HGNC:2068 CDC-like kinase 1 P49759 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8617202,1986248,12773558,12773558,10954422 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CLK2 HGNC:2069 CDC-like kinase 2 P49760 Isoform 1: Nucleus. Nucleus speckle. Isoform 2: Nucleus speckle. Note=Co- localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9637771,12670948,12670948 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA CLK3 HGNC:2071 CDC-like kinase 3 P49761 Isoform 1: Nucleus. Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Isoform 2: Nucleus speckle. Note=Co- localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. Nucleus (GO:0005634) 9637771,17000644 nucleus 50 0 nucleus nucleus Tetrapoda Tetrapoda Cell.Organisms CLK4 HGNC:13659 CDC-like kinase 4 Q9HAZ1 Nucleus (By similarity). Nucleus (GO:0005634) 12169693 nucleus 96 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms CLLU1 HGNC:29841 chronic lymphocytic leukemia up-regulated 1 Q5K131 Cytoplasm. Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL) cells. cytoplasm 100 2 cytoplasm cytoplasm Human Human Euarchontoglires CLLU1OS HGNC:24070 chronic lymphocytic leukemia up-regulated 1 opposite strand Q5K130 secreted 24 0 secreted secreted Homininae Homininae Euarchontoglires CLMN HGNC:19972 calmin (calponin-like, transmembrane) Q96JQ2 Membrane; Single-pass type IV membrane protein (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 11386753,11386753 cytoplasm 31 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CLMP HGNC:24039 CXADR-like membrane protein Q9H6B4 Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein (Potential). plasma membrane 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa CLN3 HGNC:2074 ceroid-lipofuscinosis, neuronal 3 Q13286 Lysosome membrane; Multi-pass membrane protein. Late endosome. Mitochondrion (GO:0005739); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Endosome (GO:0005768); Lysosome (GO:0005764); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 8980123,9949212,10332042,9949212,9949212,10332042,9949212,10332042,14622109,9949212,10191116,9949212,10332042,9949212,10332042,10191116 vacuole membrane 27 12 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome. lysosome membrane. mitochondrion. nucleus. plasma membrane multiple Opisthokonta Eukaryota Eukaryota CLN5 HGNC:2076 ceroid-lipofuscinosis, neuronal 5 O75503 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576) 11971870,12134079,11971870 secreted 46 2 lysosome. secreted multiple Euteleostomi Euteleostomi Eukaryota CLN6 HGNC:2077 ceroid-lipofuscinosis, neuronal 6, late infantile, variant Q9NWW5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11791207,17081983,17081983 endoplasmic reticulum membrane 100 7 cytoplasm. endoplasmic reticulum membrane. nucleus. plasma membrane multiple Amniota Euteleostomi Bilateria CLN8 HGNC:2079 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) Q9UBY8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10861296,10861296,10861296 plasma membrane 39 7 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. plasma membrane multiple Theria Euteleostomi Opisthokonta CLNK HGNC:17438 cytokine-dependent hematopoietic cell linker Q7Z7G1 cytoplasm 24 0 cytoplasm cytoplasm Theria Euteleostomi Holozoa CLNS1A HGNC:2080 chloride channel, nucleotide-sensitive, 1A P54105 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=A small fraction is also associated with the cytoskeleton. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9359436,17081983,17081983 nucleus 45 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CLOCK HGNC:2082 clock circadian regulator O15516 Nucleus. Chromosome. Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus (By similarity). Localizes to sites of DNA damage in a H2AX- independent manner. Nucleus (GO:0005634) ,17310242 nucleus 46 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms CLP1 HGNC:16999 cleavage and polyadenylation factor I subunit 1 Q92989 Nucleus. Integral to membrane (GO:0016021) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms CLPB HGNC:30664 ClpB caseinolytic peptidase B homolog (E. coli) Q9H078 Nucleus (GO:0005634) 17081983 nucleus 28 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms CLPP HGNC:2084 caseinolytic mitochondrial matrix peptidase proteolytic subunit Q16740 Mitochondrion matrix. Mitochondrion (GO:0005739) 11923310,9512494 mitochondrion 100 1 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms CLPS HGNC:2085 colipase, pancreatic P04118 Secreted. Extracellular (GO:0005576); Zymogen granule (GO:0042588) 12598038,16278343 secreted 100 0 secreted secreted Theria Chordata Chordata CLPSL1 HGNC:21251 colipase-like 1 A2RUU4 Secreted (Potential). Extracellular (GO:0005576) secreted 28 0 secreted secreted Catarrhini Catarrhini Amniota CLPSL2 HGNC:21250 colipase-like 2 Q6UWE3 Secreted (Probable). secreted 29 0 secreted secreted Eutheria Eutheria Eutheria CLPTM1 HGNC:2087 cleft lip and palate associated transmembrane protein 1 O96005 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 77 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota CLPTM1L HGNC:24308 CLPTM1-like Q96KA5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021); Mitochondrion (GO:0005739) none,15561729,15598749 endoplasmic reticulum membrane 83 6 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota CLPX HGNC:2088 caseinolytic mitochondrial matrix peptidase chaperone subunit O76031 Mitochondrion. Mitochondrion (GO:0005739) 10347188,11003706,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms CLRN1 HGNC:12605 clarin 1 P58418 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12080385 golgi apparatus membrane 24 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Bilateria CLRN2 HGNC:33939 clarin 2 A0PK11 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 24 4 golgi apparatus membrane golgi apparatus membrane NA NA Bilateria CLRN3 HGNC:20795 clarin 3 Q8NCR9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 30 4 golgi apparatus membrane golgi apparatus membrane Human Amniota Chordata CLSPN HGNC:19715 claspin Q9HAW4 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12766152,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa CLSTN1 HGNC:17447 calsyntenin 1 O94985 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity). Nucleus. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Vesicle (None); Cell projection (GO:0042995) 11161476,17332754,17332754,17332754,17332754 plasma membrane 20 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms CLSTN2 HGNC:17448 calsyntenin 2 Q9H4D0 Cell membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12498782,12498782,12498782 plasma membrane 21 1 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Bilateria Cell.Organisms CLSTN3 HGNC:18371 calsyntenin 3 Q9BQT9 Cell membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12498782,12498782,12498782 plasma membrane 17 1 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Bilateria Holozoa CLTA HGNC:2090 clathrin, light chain A P09496 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cell surface (GO:0009986); Perinuclear region (GO:0048471) 12589051,12589051,12589051,15703209,15703209 nucleus 37 0 cytoplasm. golgi apparatus multiple Bilateria Opisthokonta Eukaryota CLTB HGNC:2091 clathrin, light chain B P09497 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 12589051,12589051,12589051 nucleus 39 0 cytoplasm. golgi apparatus multiple Euteleostomi Eukaryota Eukaryota CLTC HGNC:2092 clathrin, heavy chain (Hc) Q00610 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 2154445,12589051,12589051,6147350,12589051,16225871,15561729,15598749 cytoplasm 38 0 cytoplasm. endosome. golgi apparatus. melanosome. mitochondrion multiple Eukaryota Eukaryota Eukaryota CLTCL1 HGNC:2093 clathrin, heavy chain-like 1 P53675 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Cytoplasmic face of coated pits and vesicles (By similarity). Clathrin-coated vesicle (GO:0030136) 8844170 cytoplasm 36 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CLU HGNC:2095 clusterin P10909 Isoform 1: Secreted. Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule (By similarity). Note=Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Zymogen granule (GO:0042588) 12470829,12200037,16188874,11906815,8634259,12551933,12551933,16278343 secreted 97 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Euteleostomi Euteleostomi Euteleostomi CLUAP1 HGNC:19009 clusterin associated protein 1 Q96AJ1 Nucleus. Cell projection, cilium. Nucleus (GO:0005634) 15480429 nucleus 16 0 nucleus nucleus Bilateria Eukaryota Eukaryota CLUH HGNC:29094 clustered mitochondria (cluA/CLU1) homolog O75153 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 46 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms CLUL1 HGNC:2096 clusterin-like 1 (retinal) Q15846 Secreted (Probable). Extracellular (GO:0005576) 10675623 secreted 95 0 secreted secreted Amniota Euteleostomi Opisthokonta CLVS1 HGNC:23139 clavesin 1 Q8IUQ0 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). Early endosome membrane; Peripheral membrane protein. cytoplasm 26 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota CLVS2 HGNC:23046 clavesin 2 Q5SYC1 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). Early endosome membrane; Peripheral membrane protein. cytoplasm 28 0 cytoplasm cytoplasm Theria Bilateria Eukaryota CLYBL HGNC:18355 citrate lyase beta like Q8N0X4 Mitochondrion (Potential). mitochondrion 49 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms CMA1 HGNC:2097 chymase 1, mast cell P23946 Secreted. Cytoplasmic granule. Note=Mast cell granules. Extracellular (GO:0005576) 7682566 cytoplasm 39 0 secreted secreted Human Theria Cell.Organisms CMAS HGNC:18290 cytidine monophosphate N-acetylneuraminic acid synthetase Q8NFW8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9689047,11893746,9689047 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms CMBL HGNC:25090 carboxymethylenebutenolidase homolog (Pseudomonas) Q96DG6 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms CMC1 HGNC:28783 C-x(9)-C motif containing 1 Q7Z7K0 Mitochondrion. Note=Colocalizes with MT-CO1. mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Holozoa CMC2 HGNC:24447 C-x(9)-C motif containing 2 Q9NRP2 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Chordata Eukaryota Eukaryota CMC4 HGNC:35428 C-x(9)-C motif containing 4 P56277 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Eutheria Eutheria NA CMIP HGNC:24319 c-Maf inducing protein Q8IY22 Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients. nucleus 73 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms CMKLR1 HGNC:2121 chemokine-like receptor 1 Q99788 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8976386 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Metazoa CMPK1 HGNC:18170 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic P30085 Nucleus. Cytoplasm. Note=Predominantly nuclear. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10462544,10462544 cytoplasm 28 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CMPK2 HGNC:27015 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial Q5EBM0 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota CMSS1 HGNC:28666 cms1 ribosomal small subunit homolog (yeast) Q9BQ75 mitochondrion 12 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota CMTM1 HGNC:19172 CKLF-like MARVEL transmembrane domain containing 1 Q8IZ96 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 19 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Theria Mammalia CMTM2 HGNC:19173 CKLF-like MARVEL transmembrane domain containing 2 Q8TAZ6 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 30 4 plasma membrane plasma membrane Eutheria Eutheria Eutheria CMTM3 HGNC:19174 CKLF-like MARVEL transmembrane domain containing 3 Q96MX0 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 36 3 plasma membrane plasma membrane Eutheria Euteleostomi Euteleostomi CMTM4 HGNC:19175 CKLF-like MARVEL transmembrane domain containing 4 Q8IZR5 Membrane; Multi-pass membrane protein. plasma membrane 29 4 plasma membrane plasma membrane Deuterostomia Bilateria Eumetazoa CMTM5 HGNC:19176 CKLF-like MARVEL transmembrane domain containing 5 Q96DZ9 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 20 4 plasma membrane plasma membrane Theria Theria Euteleostomi CMTM6 HGNC:19177 CKLF-like MARVEL transmembrane domain containing 6 Q9NX76 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) endoplasmic reticulum membrane 49 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Craniata CMTM7 HGNC:19178 CKLF-like MARVEL transmembrane domain containing 7 Q96FZ5 Membrane; Multi-pass membrane protein. plasma membrane 26 4 plasma membrane plasma membrane Chordata Chordata Bilateria CMTM8 HGNC:19179 CKLF-like MARVEL transmembrane domain containing 8 Q8IZV2 Isoform 1: Membrane; Multi-pass membrane protein. Isoform 2: Cytoplasm. Nucleus. Plasma membrane (GO:0005886) 16263120 endoplasmic reticulum membrane 51 4 cytoplasm. nucleus. plasma membrane multiple Amniota Chordata Bilateria CMTR1 HGNC:21077 cap methyltransferase 1 Q8N1G2 Nucleus. Cytoplasm (GO:0005737) 17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CMTR2 HGNC:25635 cap methyltransferase 2 Q8IYT2 Membrane; Single-pass membrane protein (Potential). nucleus 14 2 nucleus nucleus Bilateria Eukaryota Eukaryota CMYA5 HGNC:14305 cardiomyopathy associated 5 Q8N3K9 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasm, myofibril, sarcomere, M line. Note=Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z- disks. Occasionnally present at the M-band level. Sarcoplasm (GO:0016528); Microsome (GO:0005792) 14688250,14688250 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa CNBD1 HGNC:26663 cyclic nucleotide binding domain containing 1 Q8NA66 nucleus 28 0 nucleus nucleus Euarchontoglires Deuterostomia Eumetazoa CNBD2 HGNC:16145 cyclic nucleotide binding domain containing 2 Q96M20 nucleus 33 0 nucleus nucleus Mammalia Cell.Organisms Cell.Organisms CNBP HGNC:13164 CCHC-type zinc finger, nucleic acid binding protein P62633 Cytoplasm (By similarity). Endoplasmic reticulum (By similarity). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 7896269,7896269 nucleus 39 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Eukaryota CNDP1 HGNC:20675 carnosine dipeptidase 1 (metallopeptidase M20 family) Q96KN2 Secreted. Cytoplasm (GO:0005737) 12473676 secreted 100 0 cytoplasm. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms CNDP2 HGNC:24437 CNDP dipeptidase 2 (metallopeptidase M20 family) Q96KP4 Cytoplasm. Cytoplasm (GO:0005737) 12473676 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CNEP1R1 HGNC:26759 CTD nuclear envelope phosphatase 1 regulatory subunit 1 Q8N9A8 Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Note=Filamentous pattern in the cytoplasm. Integral to membrane (GO:0016021) plasma membrane 23 2 cytoplasm. nucleus membrane multiple Euarchontoglires Bilateria Metazoa CNFN HGNC:30183 cornifelin Q9BYD5 Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota CNGA1 HGNC:2148 cyclic nucleotide gated channel alpha 1 P29973 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12467592 secreted 23 4 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms CNGA2 HGNC:2149 cyclic nucleotide gated channel alpha 2 Q16280 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 8 4 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms CNGA3 HGNC:2150 cyclic nucleotide gated channel alpha 3 Q16281 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10888875 cytoplasm 12 5 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms CNGA4 HGNC:2152 cyclic nucleotide gated channel alpha 4 Q8IV77 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11739959 plasma membrane 7 5 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CNGB1 HGNC:2151 cyclic nucleotide gated channel beta 1 Q14028 Membrane; Multi-pass membrane protein. Nucleolus (GO:0005730) 11074001 nucleus 12 5 nucleus nucleus Bilateria Bilateria Cell.Organisms CNGB3 HGNC:2153 cyclic nucleotide gated channel beta 3 Q9NQW8 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10888875 cytoplasm 17 6 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms CNIH1 HGNC:19431 cornichon family AMPA receptor auxiliary protein 1 O95406 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 58 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota CNIH2 HGNC:28744 cornichon family AMPA receptor auxiliary protein 2 Q6PI25 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells) (By similarity). endoplasmic reticulum membrane 41 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Euteleostomi Eukaryota CNIH3 HGNC:26802 cornichon family AMPA receptor auxiliary protein 3 Q8TBE1 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells) (By similarity). endoplasmic reticulum membrane 43 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Opisthokonta CNIH4 HGNC:25013 cornichon family AMPA receptor auxiliary protein 4 Q9P003 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 22 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Eukaryota CNKSR1 HGNC:19700 connector enhancer of kinase suppressor of Ras 1 Q969H4 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Actin cytoskeleton (GO:0015629); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 15670823,15075335,15075335 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CNKSR2 HGNC:19701 connector enhancer of kinase suppressor of Ras 2 Q8WXI2 Cytoplasm. Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14597674,14597674 cytoplasm 23 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota CNKSR3 HGNC:23034 CNKSR family member 3 Q6P9H4 nucleus 36 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms CNN1 HGNC:2155 calponin 1, basic, smooth muscle P51911 Cytoplasm (GO:0005737) 9645345,9049805 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota CNN2 HGNC:2156 calponin 2 Q99439 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 9049805,12388067,15598749 cytoplasm 18 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Eukaryota CNN3 HGNC:2157 calponin 3, acidic Q15417 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10457177,17081983,17081983 cytoplasm 15 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota CNNM1 HGNC:102 cyclin M1 Q9NRU3 Cell membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12657465,14723793 plasma membrane 93 4 nucleus. plasma membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms CNNM2 HGNC:103 cyclin M2 Q9H8M5 Cell membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634) 12657465 plasma membrane 97 4 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms CNNM3 HGNC:104 cyclin M3 Q8NE01 Cell membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634) 12657465 plasma membrane 45 4 nucleus nucleus Mammalia Tetrapoda Cell.Organisms CNNM4 HGNC:105 cyclin M4 Q6P4Q7 Cell membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 12657465 plasma membrane 100 4 nucleus. plasma membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms CNOT1 HGNC:7877 CCR4-NOT transcription complex, subunit 1 A5YKK6 Cytoplasm, P-body. Nucleus (Probable). Note=NANOS2 promotes its localization to P-body (By similarity). Nucleus (GO:0005634) nucleus 61 2 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CNOT10 HGNC:23817 CCR4-NOT transcription complex, subunit 10 Q9H9A5 Cytoplasm (Probable). Nucleus (Probable). nucleus 48 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota CNOT11 HGNC:25217 CCR4-NOT transcription complex, subunit 11 Q9UKZ1 Cytoplasm (Probable). Nucleus (Probable). nucleus 58 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota CNOT2 HGNC:7878 CCR4-NOT transcription complex, subunit 2 Q9NZN8 Cytoplasm. Nucleus (Probable). Nucleus (GO:0005634) nucleus 19 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CNOT3 HGNC:7879 CCR4-NOT transcription complex, subunit 3 O75175 Cytoplasm (Probable). Nucleus (Probable). Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body (By similarity). Nucleus (GO:0005634) nucleus 20 0 cytoplasm. nucleus multiple Theria Eukaryota NA CNOT4 HGNC:7880 CCR4-NOT transcription complex, subunit 4 O95628 Cytoplasm (Probable). Nucleus (Probable). Nucleus (GO:0005634) nucleus 93 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota CNOT6 HGNC:14099 CCR4-NOT transcription complex, subunit 6 Q9ULM6 Cytoplasm (Probable). Nucleus (Probable). Nucleus (GO:0005634) cytoplasm 28 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CNOT6L HGNC:18042 CCR4-NOT transcription complex, subunit 6-like Q96LI5 Cytoplasm. Nucleus. secreted 27 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms CNOT7 HGNC:14101 CCR4-NOT transcription complex, subunit 7 Q9UIV1 Nucleus. Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9820826,9820826 nucleus 72 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CNOT8 HGNC:9207 CCR4-NOT transcription complex, subunit 8 Q9UFF9 Cytoplasm. Nucleus. Nucleus (GO:0005634) 9820826 nucleus 64 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CNP HGNC:2158 2',3'-cyclic nucleotide 3' phosphodiesterase P09543 Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 2164018,2161933,10646504,2164018,17215244 cytoplasm 38 0 cytoplasm. melanosome multiple Euteleostomi Bilateria NA CNPPD1 HGNC:25220 cyclin Pas1/PHO80 domain containing 1 Q9BV87 Membrane; Single-pass membrane protein (Potential). nucleus 49 3 nucleus nucleus Bilateria Eukaryota Eukaryota CNPY1 HGNC:27786 canopy FGF signaling regulator 1 Q3B7I2 endoplasmic reticulum 38 0 endoplasmic reticulum endoplasmic reticulum Mammalia Mammalia Deuterostomia CNPY2 HGNC:13529 canopy FGF signaling regulator 2 Q9Y2B0 Endoplasmic reticulum (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 12826659,12826659 endoplasmic reticulum 29 0 cytoplasm cytoplasm NA NA Eukaryota CNPY3 HGNC:11968 canopy FGF signaling regulator 3 Q9BT09 Endoplasmic reticulum (By similarity). endoplasmic reticulum 86 0 endoplasmic reticulum endoplasmic reticulum Mammalia Euteleostomi Holozoa CNPY4 HGNC:28631 canopy FGF signaling regulator 4 Q8N129 Secreted (Potential). endoplasmic reticulum 40 0 endoplasmic reticulum endoplasmic reticulum Mammalia Bilateria Holozoa CNR1 HGNC:2159 cannabinoid receptor 1 (brain) P21554 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12920192,14580383 plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Eumetazoa CNR2 HGNC:2160 cannabinoid receptor 2 (macrophage) P34972 Cell membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity). Perikaryon (By similarity). Note=Localizes to apical dendrite of pyramidal neurons (By similarity). Plasma membrane (GO:0005886) 10051546 plasma membrane 32 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa CNRIP1 HGNC:24546 cannabinoid receptor interacting protein 1 Q96F85 cytoplasm 35 0 cytoplasm cytoplasm Euteleostomi Bilateria Metazoa CNST HGNC:26486 consortin, connexin sorting protein Q6PJW8 Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway. cytoplasm 12 1 golgi apparatus membrane. plasma membrane multiple Amniota Euteleostomi Bilateria CNTD1 HGNC:26847 cyclin N-terminal domain containing 1 Q8N815 nucleus 38 3 nucleus nucleus Mammalia Euteleostomi Metazoa CNTD2 HGNC:25805 cyclin N-terminal domain containing 2 Q9H8S5 nucleus 16 1 nucleus nucleus Catarrhini Catarrhini Eukaryota CNTF HGNC:2169 ciliary neurotrophic factor P26441 Cytoplasm. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 7852996,7852996 cytoplasm 100 0 cytoplasm. secreted multiple NA NA Amniota CNTFR HGNC:2170 ciliary neurotrophic factor receptor P26992 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 1648265 secreted 15 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Chordata CNTLN HGNC:23432 centlein, centrosomal protein Q9NXG0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associated with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa CNTN1 HGNC:2171 contactin 1 Q12860 Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 7959734,14676309,17254974,11556889,9651216 plasma membrane 14 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms CNTN2 HGNC:2172 contactin 2 (axonal) Q02246 Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 8344273,1720120,12139915 plasma membrane 14 0 secreted secreted Bilateria Bilateria Cell.Organisms CNTN3 HGNC:2173 contactin 3 (plasmacytoma associated) Q9P232 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). plasma membrane 13 0 n/a n/a Bilateria Bilateria Cell.Organisms CNTN4 HGNC:2174 contactin 4 Q8IWV2 Cell membrane; Lipid-anchor, GPI-anchor. Secreted (By similarity). Plasma membrane (GO:0005886) 15106122,9221934,8586965 plasma membrane 12 0 n/a n/a Bilateria Bilateria Cell.Organisms CNTN5 HGNC:2175 contactin 5 O94779 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). plasma membrane 12 0 n/a n/a Bilateria Bilateria Cell.Organisms CNTN6 HGNC:2176 contactin 6 Q9UQ52 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). plasma membrane 12 0 n/a n/a Bilateria Bilateria Cell.Organisms CNTNAP1 HGNC:8011 contactin associated protein 1 P78357 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11496158 plasma membrane 29 1 plasma membrane plasma membrane Bilateria Bilateria Eukaryota CNTNAP2 HGNC:13830 contactin associated protein-like 2 Q9UHC6 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10624965,12809671,12975355 plasma membrane 27 1 plasma membrane plasma membrane Bilateria Bilateria Eukaryota CNTNAP3 HGNC:13834 contactin associated protein-like 3 Q9BZ76 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Probable). Plasma membrane (GO:0005886) secreted 23 1 secreted secreted Bilateria Bilateria Eukaryota CNTNAP3B HGNC:32035 contactin associated protein-like 3B Q96NU0 Membrane; Single-pass type I membrane protein (Potential). secreted 22 1 secreted secreted Bilateria Bilateria Eukaryota CNTNAP4 HGNC:18747 contactin associated protein-like 4 Q9C0A0 Membrane; Single-pass type I membrane protein (Potential). secreted 24 1 secreted secreted Bilateria Bilateria Eukaryota CNTNAP5 HGNC:18748 contactin associated protein-like 5 Q8WYK1 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 24 1 secreted secreted Bilateria Bilateria Eukaryota CNTRL HGNC:1858 centriolin Q7Z7A1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=During cytokinesis, localizes to a ring-like structure at the central midbody. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 11956314,10688839,15561729,10688839 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms CNTROB HGNC:29616 centrobin, centrosomal BRCA2 interacting protein Q8N137 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole- associated, asymmetrically localizes to the daughter centriole. Centriole (GO:0005814) 16275750 cytoplasm 100 0 cytoplasm cytoplasm Theria Bilateria Holozoa COA1 HGNC:21868 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) Q9GZY4 Mitochondrion inner membrane; Single-pass membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Catarrhini Euteleostomi Holozoa COA3 HGNC:24990 cytochrome c oxidase assembly factor 3 Q9Y2R0 Mitochondrion inner membrane; Single-pass membrane protein. Integral to membrane (GO:0016021) mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Tetrapoda Tetrapoda Bilateria COA4 HGNC:24604 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) Q9NYJ1 Mitochondrion (By similarity). nucleus 45 0 nucleus nucleus Amniota Opisthokonta Opisthokonta COA5 HGNC:33848 cytochrome c oxidase assembly factor 5 Q86WW8 mitochondrion 46 0 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota COA6 HGNC:18025 cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae) Q5JTJ3 Mitochondrion (By similarity). Mitochondrion (GO:0005739) mitochondrion 75 0 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota COA7 HGNC:25716 cytochrome c oxidase assembly factor 7 (putative) Q96BR5 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms COASY HGNC:29932 CoA synthase Q13057 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11980892,14514684 cytoplasm 9 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms COBL HGNC:22199 cordon-bleu WH2 repeat protein O75128 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell projection, ruffle (By similarity). Cytoplasm (By similarity). Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). nucleus 67 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria COBLL1 HGNC:23571 cordon-bleu WH2 repeat protein-like 1 Q53SF7 cytoplasm 16 0 cytoplasm cytoplasm Amniota Euteleostomi Bilateria COCH HGNC:2180 cochlin O43405 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 9441737,9931344 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms COG1 HGNC:6545 component of oligomeric golgi complex 1 Q8WTW3 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11980916,11980916,9927668 nucleus 71 0 cytoplasm. golgi apparatus multiple Tetrapoda Eukaryota Eukaryota COG2 HGNC:6546 component of oligomeric golgi complex 2 Q14746 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 7962052,7962052 nucleus 83 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota COG3 HGNC:18619 component of oligomeric golgi complex 3 Q96JB2 Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the peripheral membrane of cis/medial cisternae. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11292827,11292827 nucleus 72 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota COG4 HGNC:18620 component of oligomeric golgi complex 4 Q9H9E3 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11703943,11980916 nucleus 80 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota COG5 HGNC:14857 component of oligomeric golgi complex 5 Q9UP83 Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11980916,9792665,9792665 nucleus 83 0 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota COG6 HGNC:18621 component of oligomeric golgi complex 6 Q9Y2V7 Golgi apparatus membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) ,11980916 nucleus 77 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota COG7 HGNC:18622 component of oligomeric golgi complex 7 P83436 Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11980916,11980916 nucleus 63 0 cytoplasm. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota COG8 HGNC:18623 component of oligomeric golgi complex 8 Q96MW5 Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11703943,11703943 nucleus 82 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota COIL HGNC:2184 coilin P38432 Nucleus. Note=Nuclear coiled body located in the interchromatin space between the nucleolus and the nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12757932,7490287,11792806,11102515,15635413,11790298 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Opisthokonta COL10A1 HGNC:2185 collagen, type X, alpha 1 Q03692 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8304336 secreted 47 0 secreted secreted Mammalia Mammalia Bilateria COL11A1 HGNC:2186 collagen, type XI, alpha 1 P12107 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 2591970 secreted 42 0 secreted secreted Deuterostomia Bilateria Cell.Organisms COL11A2 HGNC:2187 collagen, type XI, alpha 2 P13942 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11341341 secreted 51 0 secreted secreted Deuterostomia Bilateria NA COL12A1 HGNC:2188 collagen, type XII, alpha 1 Q99715 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 3476925 secreted 33 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms COL13A1 HGNC:2190 collagen, type XIII, alpha 1 Q5TAT6 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 11956183 plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms COL14A1 HGNC:2191 collagen, type XIV, alpha 1 Q05707 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 1716629 secreted 70 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms COL15A1 HGNC:2192 collagen, type XV, alpha 1 P39059 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 1427836,8106446 secreted 43 0 secreted secreted Amniota Bilateria Bilateria COL16A1 HGNC:2193 collagen, type XVI, alpha 1 Q07092 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 7836360 secreted 100 0 secreted secreted Amniota Amniota Eumetazoa COL17A1 HGNC:2194 collagen, type XVII, alpha 1 Q9UMD9 Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. 120 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Localized in the lamina lucida beneath the hemidesmosomes. Plasma membrane (GO:0005886); Desmosome (GO:0030057) 11514543,14668477,9087447 secreted 39 1 plasma membrane plasma membrane Amniota Euteleostomi Euteleostomi COL18A1 HGNC:2195 collagen, type XVIII, alpha 1 P39060 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8183893 secreted 44 0 secreted secreted Chordata Chordata Cell.Organisms COL19A1 HGNC:2196 collagen, type XIX, alpha 1 Q14993 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 9344653 secreted 42 0 secreted secreted Chordata Chordata Cell.Organisms COL1A1 HGNC:2197 collagen, type I, alpha 1 P02452 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11143996 secreted 35 0 secreted secreted Deuterostomia Bilateria Cell.Organisms COL1A2 HGNC:2198 collagen, type I, alpha 2 P08123 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11143996 secreted 35 0 secreted secreted Deuterostomia Bilateria Holozoa COL20A1 HGNC:14670 collagen, type XX, alpha 1 Q9P218 Secreted, extracellular space (Probable). plasma membrane 38 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms COL21A1 HGNC:17025 collagen, type XXI, alpha 1 Q96P44 Secreted, extracellular space, extracellular matrix. Cytoplasm. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle. Extracellular (GO:0005576) 11566190 secreted 43 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Cell.Organisms COL22A1 HGNC:22989 collagen, type XXII, alpha 1 Q8NFW1 Secreted, extracellular space, extracellular matrix. Cytoplasm (By similarity). secreted 55 0 secreted secreted Amniota Euteleostomi Cell.Organisms COL23A1 HGNC:22990 collagen, type XXIII, alpha 1 Q86Y22 Cell membrane; Single-pass type II membrane protein; Extracellular side (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12644459,12644459 plasma membrane 90 1 plasma membrane. secreted multiple Amniota Euteleostomi Cell.Organisms COL24A1 HGNC:20821 collagen, type XXIV, alpha 1 Q17RW2 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) secreted 73 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms COL25A1 HGNC:18603 collagen, type XXV, alpha 1 Q9BXS0 Membrane; Single-pass type II membrane protein (Potential). Note=After proteolytic cleavage, CLAC is secreted. Extracellular (GO:0005576) 11927537 secreted 42 1 secreted secreted Euteleostomi Euteleostomi Cell.Organisms COL26A1 HGNC:18038 collagen, type XXVI, alpha 1 Q96A83 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12145293,12221002,12145293,12221002,12221002 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Tetrapoda Tetrapoda Eumetazoa COL27A1 HGNC:22986 collagen, type XXVII, alpha 1 Q8IZC6 Secreted, extracellular space, extracellular matrix. Note=Found on some small banded collagen fibrils and meshworks (By similarity). Extracellular (GO:0005576) 12766169 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms COL28A1 HGNC:22442 collagen, type XXVIII, alpha 1 Q2UY09 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Extracellular (GO:0005576) 16330543 secreted 38 0 secreted secreted Human Euteleostomi Cell.Organisms COL2A1 HGNC:2200 collagen, type II, alpha 1 P02458 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11705992 secreted 41 0 secreted secreted Deuterostomia Bilateria Cell.Organisms COL3A1 HGNC:2201 collagen, type III, alpha 1 P02461 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 9050868 plasma membrane 40 0 secreted secreted Homininae Amniota Holozoa COL4A1 HGNC:2202 collagen, type IV, alpha 1 P02462 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576); Extracellular matrix (GO:0005578) 9673377,14732718 secreted 48 0 secreted secreted Bilateria Bilateria Cell.Organisms COL4A2 HGNC:2203 collagen, type IV, alpha 2 P08572 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 9673377 secreted 43 0 secreted secreted Bilateria Bilateria Cell.Organisms COL4A3 HGNC:2204 collagen, type IV, alpha 3 (Goodpasture antigen) Q01955 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL) (By similarity). Extracellular (GO:0005576) 9673377 secreted 38 0 secreted secreted Bilateria Bilateria Cell.Organisms COL4A3BP HGNC:2205 collagen, type IV, alpha 3 (Goodpasture antigen) binding protein Q9Y5P4 Cytoplasm. Golgi apparatus. Endoplasmic reticulum. Note=Preferentially localized to the Golgi apparatus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10212244,17081983,10212244,10212244 cytoplasm 7 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Bilateria Bilateria Eukaryota COL4A4 HGNC:2206 collagen, type IV, alpha 4 P53420 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL) (By similarity). Extracellular (GO:0005576) 9673377 secreted 38 0 secreted secreted Human Mammalia Cell.Organisms COL4A5 HGNC:2207 collagen, type IV, alpha 5 P29400 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 9673377 secreted 46 0 secreted secreted Amniota Amniota Metazoa COL4A6 HGNC:2208 collagen, type IV, alpha 6 Q14031 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 9673377 secreted 33 0 secreted secreted Bilateria Bilateria Cell.Organisms COL5A1 HGNC:2209 collagen, type V, alpha 1 P20908 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 1572660 secreted 39 0 secreted secreted Deuterostomia Bilateria Holozoa COL5A2 HGNC:2210 collagen, type V, alpha 2 P05997 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 12145749 secreted 39 0 secreted secreted Deuterostomia Bilateria Cell.Organisms COL5A3 HGNC:14864 collagen, type V, alpha 3 P25940 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 1916105 secreted 35 0 secreted secreted Deuterostomia Bilateria Cell.Organisms COL6A1 HGNC:2211 collagen, type VI, alpha 1 P12109 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8782832 secreted 40 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms COL6A2 HGNC:2212 collagen, type VI, alpha 2 P12110 Secreted, extracellular space, extracellular matrix. Membrane; Peripheral membrane protein. Note=Recruited on membranes by CSPG4. Extracellular (GO:0005576) 11865138 secreted 44 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms COL6A3 HGNC:2213 collagen, type VI, alpha 3 P12111 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8782832,9516440 secreted 35 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms COL6A5 HGNC:26674 collagen, type VI, alpha 5 A8TX70 Secreted, extracellular space, extracellular matrix (By similarity). Note=Deposed in the extracellular matrix of skeletal muscle (By similarity). secreted 67 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms COL6A6 HGNC:27023 collagen, type VI, alpha 6 A6NMZ7 Secreted, extracellular space, extracellular matrix (By similarity). Note=Deposed in the extracellular matrix of skeletal muscle (By similarity). secreted 79 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms COL7A1 HGNC:2214 collagen, type VII, alpha 1 Q02388 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 1871109 secreted 48 0 secreted secreted Amniota Euteleostomi Cell.Organisms COL8A1 HGNC:2215 collagen, type VIII, alpha 1 P27658 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 9438378 secreted 33 0 secreted secreted Tetrapoda Euteleostomi Bilateria COL8A2 HGNC:2216 collagen, type VIII, alpha 2 P25067 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 14990571 secreted 35 0 secreted secreted Euteleostomi Euteleostomi Bilateria COL9A1 HGNC:2217 collagen, type IX, alpha 1 P20849 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8244386 secreted 40 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms COL9A2 HGNC:2218 collagen, type IX, alpha 2 Q14055 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8244386 secreted 40 0 secreted secreted Human Euteleostomi Cell.Organisms COL9A3 HGNC:2219 collagen, type IX, alpha 3 Q14050 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 8244386 secreted 38 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms COLCA2 HGNC:26978 colorectal cancer associated 2 A8K830 secreted 48 0 secreted secreted Homininae Mammalia Amniota COLEC10 HGNC:2220 collectin sub-family member 10 (C-type lectin) Q9Y6Z7 Secreted. Note=According to PubMed:10224141, cytoplasmic. Cytoplasm (GO:0005737) 10224141 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Euteleostomi Cell.Organisms COLEC11 HGNC:17213 collectin sub-family member 11 Q9BWP8 Secreted (Potential). secreted 71 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms COLEC12 HGNC:16016 collectin sub-family member 12 Q5KU26 Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface. Plasma membrane (GO:0005886) 11162630,12761161 secreted 36 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms COLGALT1 HGNC:26182 collagen beta(1-O)galactosyltransferase 1 Q8NBJ5 Endoplasmic reticulum lumen. Note=Colocalized with PLOD3 and mannose binding lectin. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms COLGALT2 HGNC:16790 collagen beta(1-O)galactosyltransferase 2 Q8IYK4 Endoplasmic reticulum lumen (Potential). endoplasmic reticulum 59 0 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms COLQ HGNC:2226 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase Q9Y215 Cell junction, synapse. Extracellular (GO:0005576) 9689136 secreted 100 0 secreted secreted Amniota Deuterostomia Cell.Organisms COMMD1 HGNC:23024 copper metabolism (Murr1) domain containing 1 Q8N668 Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15799966/15799966,15799966 nucleus 53 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota COMMD10 HGNC:30201 COMM domain containing 10 Q9Y6G5 nucleus 3 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota COMMD2 HGNC:24993 COMM domain containing 2 Q86X83 nucleus 51 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota COMMD3 HGNC:23332 COMM domain containing 3 Q9UBI1 nucleus 45 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota COMMD4 HGNC:26027 COMM domain containing 4 Q9H0A8 nucleus 37 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota COMMD5 HGNC:17902 COMM domain containing 5 Q9GZQ3 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10918053,10918053 nucleus 76 0 cytoplasm. nucleus multiple Eutheria Bilateria Eukaryota COMMD6 HGNC:24015 COMM domain containing 6 Q7Z4G1 Nucleus. Cytoplasm. secreted 22 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota COMMD7 HGNC:16223 COMM domain containing 7 Q86VX2 Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota COMMD8 HGNC:26036 COMM domain containing 8 Q9NX08 nucleus 74 0 nucleus nucleus Euteleostomi Bilateria Eukaryota COMMD9 HGNC:25014 COMM domain containing 9 Q9P000 nucleus 67 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota COMP HGNC:2227 cartilage oligomeric matrix protein P49747 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 10405447 secreted 100 0 secreted secreted Deuterostomia Bilateria Cell.Organisms COMT HGNC:2228 catechol-O-methyltransferase P21964 Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side. Cytoplasm (GO:0005737);Endoplasmic reticulum (GO:0005783);Cytoplasm (GO:0005737) 10854207/1847521/1707278 vacuole 23 0 cytoplasm. endoplasmic reticulum. plasma membrane multiple Deuterostomia Cell.Organisms Cell.Organisms COMTD1 HGNC:26309 catechol-O-methyltransferase domain containing 1 Q86VU5 Membrane; Single-pass type II membrane protein (Potential). nucleus 28 0 nucleus nucleus Amniota Cell.Organisms Cell.Organisms COPA HGNC:2230 coatomer protein complex, subunit alpha P53621 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Xenin: Secreted (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 8355790,8355790,17215244,17215244,15598749 cytoplasm 11 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms COPB1 HGNC:2231 coatomer protein complex, subunit beta 1 P53618 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Endoplasmic reticulum- Golgi intermediate compartment. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis- Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cytoplasm, not associated with visible coats or membranes, with a minor fraction present on small clusters of tubules and vesicles (By similarity). Some association with high- density and low-density microsomes and mitochondria/nuclei fraction (By similarity). Very little found in plasma membrane fraction (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Endosome (GO:0005768); Mitochondrion (GO:0005739) 8355790,1840503,1898986,1840503,12486083,8601610,15598749 golgi apparatus 14 2 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Eukaryota COPB2 HGNC:2232 coatomer protein complex, subunit beta 2 (beta prime) P35606 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytosol (GO:0005829) 8335000,8334999,17081983,8335000,8335000,15598749,17081983,15561729 nucleus 11 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms COPE HGNC:2234 coatomer protein complex, subunit epsilon O14579 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 10531302,8355790,10469566 cytoplasm 41 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota COPG1 HGNC:2236 coatomer protein complex, subunit gamma 1 Q9Y678 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Golgi apparatus (GO:0005794) golgi apparatus 2 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota COPG2 HGNC:2237 coatomer protein complex, subunit gamma 2 Q9UBF2 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 1898986,11056392,11056392 golgi apparatus 2 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota NA COPRS HGNC:28848 coordinator of PRMT5, differentiation stimulator Q9NQ92 Nucleus. nucleus 100 0 nucleus nucleus Amniota Amniota Amniota COPS2 HGNC:30747 COP9 signalosome subunit 2 P61201 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10087198,10087198 nucleus 76 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota COPS3 HGNC:2239 COP9 signalosome subunit 3 Q9UNS2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 9535219 nucleus 7 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota COPS4 HGNC:16702 COP9 signalosome subunit 4 Q9BT78 Cytoplasm. Nucleus. nucleus 5 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota COPS5 HGNC:2240 COP9 signalosome subunit 5 Q92905 Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is diminished in the presence of IFIT3. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 14719054,14732868,10766246,11089976,14719054,14732868,10766246,10766246 nucleus 22 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota COPS6 HGNC:21749 COP9 signalosome subunit 6 Q7L5N1 Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12237292,11244567,9520381,12237292,11244567,9520381 cytoplasm 7 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota COPS7A HGNC:16758 COP9 signalosome subunit 7A Q9UBW8 Cytoplasm. Nucleus. Nucleus (GO:0005634) 12020345 nucleus 49 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota COPS7B HGNC:16760 COP9 signalosome subunit 7B Q9H9Q2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) cytoplasm 6 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota COPS8 HGNC:24335 COP9 signalosome subunit 8 Q99627 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 9535219 cytoplasm 31 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota COPZ1 HGNC:2243 coatomer protein complex, subunit zeta 1 P61923 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11056392,11056392 nucleus 26 0 cytoplasm. golgi apparatus multiple Eutheria Eukaryota Eukaryota COPZ2 HGNC:19356 coatomer protein complex, subunit zeta 2 Q9P299 Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11056392,11056392 nucleus 27 1 cytoplasm. golgi apparatus multiple Theria Euteleostomi Eukaryota COQ10A HGNC:26515 coenzyme Q10 homolog A (S. cerevisiae) Q96MF6 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity). mitochondrion 62 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms COQ10B HGNC:25819 coenzyme Q10 homolog B (S. cerevisiae) Q9H8M1 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity). mitochondrion 53 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms COQ2 HGNC:25223 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Q96H96 Mitochondrion membrane; Multi-pass membrane protein (Probable). Mitochondrion (GO:0005739) mitochondrion membrane 48 8 mitochondrion membrane mitochondrion membrane Cell.Organisms Cell.Organisms Cell.Organisms COQ3 HGNC:18175 coenzyme Q3 methyltransferase Q9NZJ6 Mitochondrion matrix (Probable). Mitochondrion (GO:0005739) 10777520 mitochondrion 23 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms COQ4 HGNC:19693 coenzyme Q4 Q9Y3A0 Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. mitochondrion 43 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms COQ5 HGNC:28722 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) Q5HYK3 Mitochondrion (By similarity). mitochondrion 37 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms COQ6 HGNC:20233 coenzyme Q6 monooxygenase Q9Y2Z9 Golgi apparatus. Cell projection (By similarity). Note=Localizes to podocyte cell processes (By similarity). mitochondrion 19 0 golgi apparatus golgi apparatus Eukaryota Cell.Organisms Cell.Organisms COQ7 HGNC:2244 coenzyme Q7 homolog, ubiquinone (yeast) Q99807 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane (By similarity). Mitochondrion (GO:0005739) 11511092,9452453 mitochondrion 53 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms COQ9 HGNC:25302 coenzyme Q9 O75208 Mitochondrion (By similarity). mitochondrion 91 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms CORIN HGNC:19012 corin, serine peptidase Q9Y5Q5 Cell membrane; Single-pass type II membrane protein. Isoform 2: Cell membrane; Single-pass type II membrane protein. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage. Plasma membrane (GO:0005886) 10880574,11082206 secreted 23 1 plasma membrane. secreted multiple Chordata Bilateria Cell.Organisms CORO1A HGNC:2252 coronin, actin binding protein, 1A P31146 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasmic vesicle, phagosome membrane (By similarity). Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12673016,15598749 cytoplasm 61 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms CORO1B HGNC:2253 coronin, actin binding protein, 1B Q9BR76 Cytoplasm, cytoskeleton. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CORO1C HGNC:2254 coronin, actin binding protein, 1C Q9ULV4 Cytoplasm (GO:0005737) 10828594 cytoplasm 68 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CORO2A HGNC:2255 coronin, actin binding protein, 2A Q92828 Nucleus (GO:0005634) 12628926 cytoplasm 38 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms CORO2B HGNC:2256 coronin, actin binding protein, 2B Q9UQ03 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10224093,10224093 cytoplasm 37 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms CORO6 HGNC:21356 coronin 6 Q6QEF8 cytoplasm 63 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms CORO7 HGNC:26161 coronin 7 P57737 Cytoplasm, cytosol (By similarity). Golgi apparatus membrane. Cytoplasmic vesicle (By similarity). Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments. Golgi membrane (GO:0000139); Cytosol (GO:0005829) 16905771,15327992,15327992 cytoplasm 11 0 cytoplasm. golgi apparatus membrane multiple Bilateria Eukaryota Cell.Organisms CORT HGNC:2257 cortistatin O00230 Secreted. Extracellular (GO:0005576) 9205124 secreted 100 0 secreted secreted NA NA Amniota COTL1 HGNC:18304 coactosin-like F-actin binding protein 1 Q14019 Cytoplasm, cytoskeleton (By similarity). Nucleus membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) 11583571 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota COX10 HGNC:2260 cytochrome c oxidase assembly homolog 10 (yeast) Q12887 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10767350 mitochondrion membrane 100 9 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms COX11 HGNC:2261 cytochrome c oxidase assembly homolog 11 (yeast) Q9Y6N1 Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Mitochondrion (GO:0005739) 9878253 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Eukaryota Cell.Organisms Cell.Organisms COX14 HGNC:28216 cytochrome c oxidase assembly homolog 14 (S. cerevisiae) Q96I36 Mitochondrion membrane; Single-pass membrane protein. Integral to membrane (GO:0016021) mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Eutheria Amniota Euteleostomi COX15 HGNC:2263 cytochrome c oxidase assembly homolog 15 (yeast) Q7KZN9 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 12474143,15598749 mitochondrion membrane 100 8 mitochondrion. mitochondrion membrane multiple Eukaryota Cell.Organisms Cell.Organisms COX16 HGNC:20213 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) Q9P0S2 Mitochondrion membrane; Single-pass membrane protein (Potential). mitochondrion membrane 89 1 mitochondrion membrane mitochondrion membrane Amniota Bilateria Opisthokonta COX17 HGNC:2264 COX17 cytochrome c oxidase copper chaperone Q14061 Mitochondrion intermembrane space (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11027508,11054125 mitochondrion 48 0 cytoplasm. mitochondrion multiple Euteleostomi Eukaryota Eukaryota COX18 HGNC:26801 COX18 cytochrome C oxidase assembly factor Q8N8Q8 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 16212937 mitochondrion membrane 100 5 mitochondrion. mitochondrion membrane multiple Opisthokonta Eukaryota Cell.Organisms COX19 HGNC:28074 cytochrome c oxidase assembly homolog 19 (S. cerevisiae) Q49B96 Cytoplasm, cytosol. Cytosol (GO:0005829) 16212937 cytoplasm 100 0 cytoplasm cytoplasm NA NA Eukaryota COX20 HGNC:26970 COX20 cytochrome C oxidase assembly factor Q5RI15 Mitochondrion membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 55 3 mitochondrion membrane mitochondrion membrane Euteleostomi Bilateria Eumetazoa COX4I1 HGNC:2265 cytochrome c oxidase subunit IV isoform 1 P13073 Mitochondrion inner membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10337626,10337626,10337626,10878243,15561729 mitochondrion 26 1 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Opisthokonta COX4I2 HGNC:16232 cytochrome c oxidase subunit IV isoform 2 (lung) Q96KJ9 Mitochondrion inner membrane. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11911854,11311561,6246917 mitochondrion 31 1 cytoplasm. mitochondrion multiple Human Human Holozoa COX5A HGNC:2267 cytochrome c oxidase subunit Va P20674 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 2853101,15598749 mitochondrion 86 0 mitochondrion mitochondrion Opisthokonta Opisthokonta Opisthokonta COX5B HGNC:2269 cytochrome c oxidase subunit Vb P10606 Mitochondrion inner membrane. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10915781,1646156,15598749,10915781,9030264,1646156 cytoplasm 22 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Eukaryota COX6A1 HGNC:2277 cytochrome c oxidase subunit VIa polypeptide 1 P12074 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 10773445 secreted 32 1 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota COX6A2 HGNC:2279 cytochrome c oxidase subunit VIa polypeptide 2 Q02221 Mitochondrion inner membrane. secreted 41 1 secreted secreted Human Human Opisthokonta COX6B1 HGNC:2280 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) P14854 Mitochondrion intermembrane space (By similarity). Mitochondrion (GO:0005739) 11943455,15598749 mitochondrion 84 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota COX6B2 HGNC:24380 cytochrome c oxidase subunit VIb polypeptide 2 (testis) Q6YFQ2 Mitochondrion intermembrane space (By similarity). Mitochondrion (GO:0005739) 12874793 mitochondrion 47 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota COX6C HGNC:2285 cytochrome c oxidase subunit VIc P09669 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 8705997 mitochondrion membrane 22 1 mitochondrion mitochondrion Deuterostomia Bilateria Metazoa COX7A1 HGNC:2287 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) P24310 Mitochondrion inner membrane. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 9344674,9752724,9752724 mitochondrion 11 1 cytoplasm. mitochondrion multiple Theria Bilateria Bilateria COX7A2 HGNC:2288 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) P14406 Mitochondrion inner membrane. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11004498,9752724,15598749,9752724 secreted 13 1 cytoplasm. mitochondrion multiple Euteleostomi Deuterostomia Bilateria COX7A2L HGNC:2289 cytochrome c oxidase subunit VIIa polypeptide 2 like O14548 Mitochondrion inner membrane (By similarity). Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 14562965,8647836 mitochondrion membrane 13 1 golgi apparatus. mitochondrion multiple Euteleostomi Euteleostomi Eumetazoa COX7B HGNC:2291 cytochrome c oxidase subunit VIIb P24311 Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739) 9660196,8781533 mitochondrion 4 1 mitochondrion mitochondrion Tetrapoda Tetrapoda NA COX7B2 HGNC:24381 cytochrome c oxidase subunit VIIb2 Q8TF08 Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739) mitochondrion 8 1 mitochondrion mitochondrion Homininae Homininae Craniata COX7C HGNC:2292 cytochrome c oxidase subunit VIIc P15954 Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 54 1 mitochondrion membrane mitochondrion membrane Euteleostomi Bilateria Eumetazoa COX8A HGNC:2294 cytochrome c oxidase subunit VIIIA (ubiquitous) P10176 Mitochondrion inner membrane. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 2543673,10637443,12909344,10637443 mitochondrion membrane 18 1 mitochondrion. nucleus multiple Theria Amniota Craniata COX8C HGNC:24382 cytochrome c oxidase subunit VIIIC Q7Z4L0 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 12909344 secreted 19 1 mitochondrion mitochondrion Homininae Euarchontoglires Amniota CP HGNC:2295 ceruloplasmin (ferroxidase) P00450 Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 6337857,6337857,10660599,16188874,9500710 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Deuterostomia Eukaryota Cell.Organisms CPA1 HGNC:2296 carboxypeptidase A1 (pancreatic) P15085 Secreted. Zymogen granule (GO:0042588) 16278343 secreted 100 0 secreted secreted Bilateria Cell.Organisms NA CPA2 HGNC:2297 carboxypeptidase A2 (pancreatic) P48052 Secreted. Extracellular (GO:0005576); Zymogen granule (GO:0042588) 8806703,9450539,16278343 secreted 100 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms CPA3 HGNC:2298 carboxypeptidase A3 (mast cell) P15088 Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules. Secretory granule (GO:0030141) 2594780,2443571,7929294 secreted 39 0 secreted secreted Theria Theria Cell.Organisms CPA4 HGNC:15740 carboxypeptidase A4 Q9UI42 Secreted (By similarity). secreted 55 0 secreted secreted Mammalia Eukaryota Cell.Organisms CPA5 HGNC:15722 carboxypeptidase A5 Q8WXQ8 Secreted (By similarity). Extracellular (GO:0005576) secreted 50 0 secreted secreted Mammalia Bilateria NA CPA6 HGNC:17245 carboxypeptidase A6 Q8N4T0 Secreted, extracellular space, extracellular matrix. secreted 100 0 secreted secreted Human Cell.Organisms Cell.Organisms CPAMD8 HGNC:23228 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 Q8IZJ3 Secreted (Probable). Cell membrane; Peripheral membrane protein; Extracellular side. secreted 14 0 secreted secreted Mammalia Deuterostomia Cell.Organisms CPB1 HGNC:2299 carboxypeptidase B1 (tissue) P15086 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 7505580,8322019 secreted 100 0 cytoplasm. secreted multiple Chordata Opisthokonta Cell.Organisms CPB2 HGNC:2300 carboxypeptidase B2 (plasma) Q96IY4 Secreted. secreted 100 0 secreted secreted Euteleostomi Bilateria Cell.Organisms CPD HGNC:2301 carboxypeptidase D O75976 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11306718,9815277,12754519,9815277,9490632,11306718,9815277,9490632,9815277,9490632 secreted 38 1 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms CPE HGNC:2303 carboxypeptidase E P16870 Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By similarity). Secreted (By similarity). Isoform 2: Nucleus. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Endoplasmic reticulum (GO:0005783) 2334405,9019408,9815277,7790890,9815277 secreted 42 0 endoplasmic reticulum. nucleus multiple Deuterostomia Bilateria Cell.Organisms CPEB1 HGNC:21744 cytoplasmic polyadenylation element binding protein 1 Q9BZB8 Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Note=Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TA3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TA3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). Cytoplasm (GO:0005737) 11223249 cytoplasm 61 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa CPEB2 HGNC:21745 cytoplasmic polyadenylation element binding protein 2 Q7Z5Q1 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12672660 cytoplasm 99 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CPEB3 HGNC:21746 cytoplasmic polyadenylation element binding protein 3 Q8NE35 cytoplasm 76 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CPEB4 HGNC:21747 cytoplasmic polyadenylation element binding protein 4 Q17RY0 Cytoplasm (GO:0005737) cytoplasm 72 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CPED1 HGNC:26159 cadherin-like and PC-esterase domain containing 1 A4D0V7 cytoplasm 16 0 cytoplasm cytoplasm Amniota Deuterostomia Holozoa CPLX1 HGNC:2309 complexin 1 O14810 Cytoplasm, cytosol (By similarity). Note=Enriched at synaptic-releasing sites in mature neurons (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 7654227,7654227 cytoplasm 96 0 cytoplasm cytoplasm Euteleostomi Bilateria Bilateria CPLX2 HGNC:2310 complexin 2 Q6PUV4 Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Ribosome (GO:0005840) 10430466,10430466,10430466,10430466 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Euteleostomi Bilateria Bilateria CPLX3 HGNC:27652 complexin 3 Q8WVH0 Membrane; Lipid-anchor. Cell junction, synapse (By similarity). Note=Enriched at the synaptic terminal (By similarity). cytoplasm 25 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata CPLX4 HGNC:24330 complexin 4 Q7Z7G2 Membrane; Lipid-anchor. Cell junction, synapse (By similarity). Note=Enriched at the synaptic terminal (By similarity). nucleus 30 0 nucleus nucleus Euteleostomi Euteleostomi Craniata CPM HGNC:2311 carboxypeptidase M P14384 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Perinuclear region (GO:0048471) 2914904,10222261,7797563,2753907,7615511,12457462 secreted 33 0 cytoplasm. secreted multiple Euteleostomi Bilateria Cell.Organisms CPN1 HGNC:2312 carboxypeptidase N, polypeptide 1 P15169 Secreted, extracellular space. Extracellular (GO:0005576) 2912725,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CPN2 HGNC:2313 carboxypeptidase N, polypeptide 2 P22792 Secreted. Extracellular (GO:0005576) 2378615 secreted 100 0 secreted secreted Euarchontoglires Cell.Organisms Cell.Organisms CPNE1 HGNC:2314 copine I Q99829 Cytoplasm (GO:0005737) 12949241 plasma membrane 10 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota CPNE2 HGNC:2315 copine II Q96FN4 Cytoplasm (GO:0005737) cytoplasm 20 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CPNE3 HGNC:2316 copine III O75131 Cytoplasm (GO:0005737) 12949241 secreted 20 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota CPNE4 HGNC:2317 copine IV Q96A23 Cytoplasm (GO:0005737) secreted 13 0 secreted secreted Euteleostomi Euteleostomi Eukaryota CPNE5 HGNC:2318 copine V Q9HCH3 Cytoplasm (GO:0005737) plasma membrane 23 0 n/a n/a Eukaryota Eukaryota Eukaryota CPNE6 HGNC:2319 copine VI (neuronal) O95741 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9886090,9886090 plasma membrane 18 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CPNE7 HGNC:2320 copine VII Q9UBL6 secreted 17 0 secreted secreted Euteleostomi Euteleostomi Eukaryota CPNE8 HGNC:23498 copine VIII Q86YQ8 plasma membrane 24 0 n/a n/a Eukaryota Eukaryota Eukaryota CPNE9 HGNC:24336 copine family member IX Q8IYJ1 plasma membrane 24 0 n/a n/a Eukaryota Eukaryota Eukaryota CPO HGNC:21011 carboxypeptidase O Q8IVL8 Secreted (Potential). Cytoplasm (GO:0005737) secreted 31 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms CPOX HGNC:2321 coproporphyrinogen oxidase P36551 Mitochondrion intermembrane space. Mitochondrion (GO:0005739) 8407975,15598749 mitochondrion 100 2 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms CPPED1 HGNC:25632 calcineurin-like phosphoesterase domain containing 1 Q9BRF8 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms CPQ HGNC:16910 carboxypeptidase Q Q9Y646 Endoplasmic reticulum. Golgi apparatus. Lysosome (By similarity). Secreted. Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin (By similarity). vacuole 18 1 endoplasmic reticulum. golgi apparatus. secreted multiple NA NA Cell.Organisms CPS1 HGNC:2323 carbamoyl-phosphate synthase 1, mitochondrial P31327 Mitochondrion. Nucleus, nucleolus. Mitochondrion (GO:0005739) 7590739,15561729 mitochondrion 76 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms CPSF1 HGNC:2324 cleavage and polyadenylation specific factor 1, 160kDa Q10570 Nucleus, nucleoplasm. Nucleus (GO:0005634) 8654386 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA CPSF2 HGNC:2325 cleavage and polyadenylation specific factor 2, 100kDa Q9P2I0 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7969155,8654386,11526086 nucleus 19 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CPSF3 HGNC:2326 cleavage and polyadenylation specific factor 3, 73kDa Q9UKF6 Nucleus. Nucleus (GO:0005634) 7969155 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms CPSF3L HGNC:26052 cleavage and polyadenylation specific factor 3-like Q5TA45 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15684398,15684398 nucleus 40 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms CPSF4 HGNC:2327 cleavage and polyadenylation specific factor 4, 30kDa O95639 Nucleus. Nucleus (GO:0005634) 7969155 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CPSF4L HGNC:33632 cleavage and polyadenylation specific factor 4-like A6NMK7 nucleus 56 0 nucleus nucleus Catarrhini Theria Eukaryota CPSF6 HGNC:13871 cleavage and polyadenylation specific factor 6, 68kDa Q16630 Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. Nucleus (GO:0005634) 8626397 nucleus 100 0 nucleus nucleus Homininae Bilateria Cell.Organisms CPSF7 HGNC:30098 cleavage and polyadenylation specific factor 7, 59kDa Q8N684 Nucleus (Probable). nucleus 40 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota CPT1A HGNC:2328 carnitine palmitoyltransferase 1A (liver) P50416 Mitochondrion outer membrane; Multi-pass membrane protein. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 9070950,15561729 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Cell.Organisms CPT1B HGNC:2329 carnitine palmitoyltransferase 1B (muscle) Q92523 Mitochondrion outer membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9344464,15598749 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Cell.Organisms CPT1C HGNC:18540 carnitine palmitoyltransferase 1C Q8TCG5 Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse (By similarity). Mitochondrion (GO:0005739); Microsome (GO:0005792); Peroxisome (GO:0005777) 12376098,12376098,12376098 mitochondrion membrane 44 3 mitochondrion. peroxisome multiple Bilateria Eukaryota Cell.Organisms CPT2 HGNC:2330 carnitine palmitoyltransferase 2 P23786 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 11001805,15598749 mitochondrion membrane 16 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms CPVL HGNC:14399 carboxypeptidase, vitellogenic-like Q9H3G5 Extracellular (GO:0005576) 11401439 secreted 31 0 secreted secreted Eukaryota Eukaryota Cell.Organisms CPXCR1 HGNC:2332 CPX chromosome region, candidate 1 Q8N123 nucleus 38 0 nucleus nucleus Catarrhini Euarchontoglires Eutheria CPXM1 HGNC:15771 carboxypeptidase X (M14 family), member 1 Q96SM3 Secreted (By similarity). secreted 38 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CPXM2 HGNC:26977 carboxypeptidase X (M14 family), member 2 Q8N436 Secreted (Probable). secreted 32 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CPZ HGNC:2333 carboxypeptidase Z Q66K79 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 10671522,9099699 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms CR1 HGNC:2334 complement component (3b/4b) receptor 1 (Knops blood group) P17927 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2989379 secreted 18 1 plasma membrane plasma membrane Amniota Chordata Eukaryota CR1L HGNC:2335 complement component (3b/4b) receptor 1-like Q2VPA4 Cytoplasm. Membrane. Secreted. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant. Membrane fraction (GO:0005624); Cytosol (GO:0005829) 14687939,14687939 secreted 15 0 cytoplasm. secreted multiple Amniota Chordata Eukaryota CR2 HGNC:2336 complement component (3d/Epstein Barr virus) receptor 2 P20023 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9796912,1323059 secreted 18 1 nucleus. plasma membrane multiple Amniota Chordata Eukaryota CRABP1 HGNC:2338 cellular retinoic acid binding protein 1 P29762 Cytoplasm. Cytoplasm (GO:0005737) 2825608 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa CRABP2 HGNC:2339 cellular retinoic acid binding protein 2 P29373 Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11909957,11909957 cytoplasm 83 0 cytoplasm. endoplasmic reticulum. nucleus multiple Theria Euteleostomi Eumetazoa CRADD HGNC:2340 CASP2 and RIPK1 domain containing adaptor with death domain P78560 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10713730,16652156,10713730 cytoplasm 35 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eumetazoa CRAMP1L HGNC:14122 Crm, cramped-like (Drosophila) Q96RY5 Nucleus (By similarity). nucleus 26 0 nucleus nucleus Chordata Bilateria Eukaryota CRAT HGNC:2342 carnitine O-acetyltransferase P43155 Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (Potential). Isoform 1: Mitochondrion (Potential). Isoform 2: Peroxisome (Potential). Mitochondrion (GO:0005739); Peroxisome (GO:0005777); Endoplasmic reticulum (GO:0005783) 7829107,7829107,7829107 mitochondrion membrane 18 0 endoplasmic reticulum. mitochondrion. peroxisome multiple Bilateria Opisthokonta Cell.Organisms CRB1 HGNC:2343 crumbs family member 1, photoreceptor morphogenesis associated P82279 Isoform 1: Apical cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11734541,10508521 secreted 29 1 plasma membrane. secreted multiple Bilateria Bilateria Eukaryota CRB2 HGNC:18688 crumbs family member 2 Q5IJ48 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 14767562,14767562 secreted 34 1 plasma membrane. secreted multiple Bilateria Bilateria Eukaryota CRB3 HGNC:20237 crumbs family member 3 Q9BUF7 Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. Apical membrane (GO:0016327) 12527193,12771187,14718572 plasma membrane 43 1 plasma membrane plasma membrane Eutheria Eutheria Euteleostomi CRBN HGNC:30185 cereblon Q96SW2 Cytoplasm. Nucleus. Membrane; Peripheral membrane protein (By similarity). nucleus 82 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CRCP HGNC:17888 CGRP receptor component O75575 Nucleus (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 10903324,11754963,11937264,12128288 nucleus 25 0 cytoplasm cytoplasm NA NA Eukaryota CRCT1 HGNC:29875 cysteine-rich C-terminal 1 Q9UGL9 secreted 88 0 secreted secreted Human Human NA CREB1 HGNC:2345 cAMP responsive element binding protein 1 P16220 Nucleus. Nucleus (GO:0005634) 12519783,16023139,16498402,19059367 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Metazoa CREB3 HGNC:2347 cAMP responsive element binding protein 3 O43889 Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane. Isoform 3: Nucleus. Cytoplasm. Processed cyclic AMP-responsive element- binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element- binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 10675342,10623756,15705566,10675342,10623756,15705566,10623756 nucleus 41 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Tetrapoda Tetrapoda Eukaryota CREB3L1 HGNC:18856 cAMP responsive element binding protein 3-like 1 Q96BA8 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-responsive element- binding protein 3-like protein 1: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 15665855/12054625,15665855,12054625,15665855,12054625 nucleus 50 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Amniota Deuterostomia Eukaryota CREB3L2 HGNC:23720 cAMP responsive element binding protein 3-like 2 Q70SY1 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-responsive element- binding protein 3-like protein 2: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Nucleus (GO:0005634) none,17081983 nucleus 53 1 endoplasmic reticulum membrane. nucleus multiple Amniota Euteleostomi Holozoa CREB3L3 HGNC:18855 cAMP responsive element binding protein 3-like 3 Q68CJ9 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-responsive element- binding protein 3-like protein 3: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11353085,11353085 nucleus 39 1 cytoplasm. endoplasmic reticulum membrane. nucleus multiple Deuterostomia Deuterostomia Eukaryota CREB3L4 HGNC:18854 cAMP responsive element binding protein 3-like 4 Q8TEY5 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Processed cyclic AMP-responsive element- binding protein 3-like protein 4: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11830526,11830526 nucleus 40 1 cytoplasm. endoplasmic reticulum membrane. nucleus multiple Theria Euteleostomi Eukaryota CREB5 HGNC:16844 cAMP responsive element binding protein 5 Q02930 Nucleus (Probable). Nucleus (GO:0005634) 8378084 nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota CREBBP HGNC:2348 CREB binding protein Q92793 Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Nucleus (GO:0005634) 11912212,15027889 nucleus 17 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CREBL2 HGNC:2350 cAMP responsive element binding protein-like 2 O60519 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 98 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa CREBRF HGNC:24050 CREB3 regulatory factor Q8IUR6 Nucleus. Note=Colocalizes with CREB3 in nuclear foci. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Eumetazoa CREBZF HGNC:24905 CREB/ATF bZIP transcription factor Q9NS37 Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1. Nucleus (GO:0005634) 10871379,15705566 nucleus 100 0 nucleus nucleus Theria Amniota Metazoa CREG1 HGNC:2351 cellular repressor of E1A-stimulated genes 1 O75629 Secreted. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Nucleus (GO:0005634) 10815803,10815803,12934103,12934103,10815803,10815803 secreted 100 0 endoplasmic reticulum. golgi apparatus. nucleus. secreted multiple Euteleostomi Bilateria Eukaryota CREG2 HGNC:14272 cellular repressor of E1A-stimulated genes 2 Q8IUH2 Secreted. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 12408961,12408961, secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Human Human Eukaryota CRELD1 HGNC:14630 cysteine-rich with EGF-like domains 1 Q96HD1 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12137942,12137942 secreted 20 2 plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms CRELD2 HGNC:28150 cysteine-rich with EGF-like domains 2 Q6UXH1 Secreted (Potential). Endoplasmic reticulum. Extracellular (GO:0005576) secreted 22 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota CREM HGNC:2352 cAMP responsive element modulator Q03060 Nucleus. Nucleus (GO:0005634) 8994192 nucleus 100 0 nucleus nucleus Eutheria Mammalia Metazoa CRH HGNC:2355 corticotropin releasing hormone P06850 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11168450,12011471 secreted 100 0 cytoplasm. secreted multiple Amniota Euteleostomi Euteleostomi CRHBP HGNC:2356 corticotropin releasing hormone binding protein P24387 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 1846945,2549150,8557170 secreted 100 0 secreted secreted Euteleostomi Bilateria Bilateria CRHR1 HGNC:2357 corticotropin releasing hormone receptor 1 P34998 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9178757,10598591 plasma membrane 88 7 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa CRHR2 HGNC:2358 corticotropin releasing hormone receptor 2 Q13324 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9717834 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa CRIM1 HGNC:2359 cysteine rich transmembrane BMP regulator 1 (chordin-like) Q9NZV1 Processed cysteine-rich motor neuron 1 protein: Secreted. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12805376,11084657 secreted 22 1 cytoplasm. plasma membrane. secreted multiple Euteleostomi Bilateria NA CRIP1 HGNC:2360 cysteine-rich protein 1 (intestinal) P50238 Cytoplasm (GO:0005737) 9126610 cytoplasm 48 0 cytoplasm cytoplasm Mammalia Eukaryota NA CRIP2 HGNC:2361 cysteine-rich protein 2 P52943 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12839623,12530967 cytoplasm 46 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota NA CRIP3 HGNC:17751 cysteine-rich protein 3 Q6Q6R5 Cytoplasm (By similarity). cytoplasm 78 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota CRIPAK HGNC:26619 cysteine-rich PAK1 inhibitor Q8N1N5 Cytoplasm. Membrane. Nucleus. Note=Translocated to the nuclear compartment upon hormonal treatment by estrogen. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16278681,16278681 secreted 65 0 cytoplasm. nucleus multiple Homininae Homininae Eukaryota CRIPT HGNC:14312 cysteine-rich PDZ-binding protein Q9P021 Cytoplasm (By similarity). Cell junction, synapse (By similarity). Cell projection, dendritic spine (By similarity). Note=Colocalizes with DLG4 in asymmetric synapses (By similarity). Cytoplasm (GO:0005737) 9581762 nucleus 54 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota CRISP1 HGNC:304 cysteine-rich secretory protein 1 P54107 Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head. Extracellular (GO:0005576) 8838800 secreted 29 0 secreted secreted Mammalia Mammalia Cell.Organisms CRISP2 HGNC:12024 cysteine-rich secretory protein 2 P16562 Secreted (Probable). Extracellular (GO:0005576) 8665901 secreted 64 0 secreted secreted Tetrapoda Opisthokonta Cell.Organisms CRISP3 HGNC:16904 cysteine-rich secretory protein 3 P54108 Secreted. Note=In neutrophils, localized in specific granules. Secretory granule (GO:0030141); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 8601434,12223513,12647793,12433721 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Opisthokonta Cell.Organisms CRISPLD1 HGNC:18206 cysteine-rich secretory protein LCCL domain containing 1 Q9H336 Secreted (Potential). Extracellular (GO:0005576) secreted 48 0 secreted secreted Euteleostomi Bilateria Cell.Organisms CRISPLD2 HGNC:25248 cysteine-rich secretory protein LCCL domain containing 2 Q9H0B8 Secreted (By similarity). secreted 72 0 secreted secreted Euteleostomi Bilateria Cell.Organisms CRK HGNC:2362 v-crk avian sarcoma virus CT10 oncogene homolog P46108 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma membrane upon cell adhesion (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 10748058,10748058,10748058 cytoplasm 40 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota CRKL HGNC:2363 v-crk avian sarcoma virus CT10 oncogene homolog-like P46109 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11097834,9872990 cytoplasm 31 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota CRLF1 HGNC:2364 cytokine receptor-like factor 1 O75462 Secreted. Extracellular (GO:0005576) 9686600 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Chordata CRLF2 HGNC:14281 cytokine receptor-like factor 2 Q9HC73 Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 2: Secreted (Probable). Plasma membrane (GO:0005886) 11418668,11237741,11474172 secreted 51 1 plasma membrane. secreted multiple Amniota Amniota Opisthokonta CRLF3 HGNC:17177 cytokine receptor-like factor 3 Q8IUI8 Cytoplasm. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic (PubMed:19427400). cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eumetazoa CRLS1 HGNC:16148 cardiolipin synthase 1 Q9UJA2 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 6 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms CRMP1 HGNC:2365 collapsin response mediator protein 1 Q14194 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813) 11562390,11562390,11562390 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms CRNKL1 HGNC:15762 crooked neck pre-mRNA splicing factor 1 Q9BZJ0 Nucleus speckle. Cytoplasm. Note=Colocalizes with core spliceosomal snRNP proteins. Also diffusely expressed in cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12084575,12084575 nucleus 96 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CRNN HGNC:1230 cornulin Q9UBG3 Cytoplasm. Note=Does not colocalize with TGM1. Plasma membrane (GO:0005886) 11056050 cytoplasm 100 0 cytoplasm cytoplasm Theria Amniota Craniata CROCC HGNC:21299 ciliary rootlet coiled-coil, rootletin Q5TZA2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 12427867,12427867 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Bilateria Eumetazoa CROT HGNC:2366 carnitine O-octanoyltransferase Q9UKG9 Peroxisome (Potential). Peroxisome (GO:0005777) 10486279 mitochondrion membrane 14 0 peroxisome peroxisome Bilateria Bilateria Cell.Organisms CRP HGNC:2367 C-reactive protein, pentraxin-related P02741 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634) 10408362,2477447 secreted 100 0 nucleus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms CRTAC1 HGNC:14882 cartilage acidic protein 1 Q9NQ79 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11139377 secreted 100 0 secreted secreted Amniota Cell.Organisms Cell.Organisms CRTAM HGNC:24313 cytotoxic and regulatory T cell molecule O95727 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 16 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Bilateria CRTAP HGNC:2379 cartilage associated protein O75718 Secreted, extracellular space, extracellular matrix (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12052827,12052827 secreted 86 0 cytoplasm cytoplasm Chordata Bilateria Metazoa CRTC1 HGNC:16062 CREB regulated transcription coactivator 1 Q6UUV9 Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983,17081983/15589160,15589160 nucleus 17 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eumetazoa CRTC2 HGNC:27301 CREB regulated transcription coactivator 2 Q53ET0 Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14506290,15454081,15454081 cytoplasm 13 0 cytoplasm. nucleus multiple Theria Theria Eumetazoa CRTC3 HGNC:26148 CREB regulated transcription coactivator 3 Q6UUV7 Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. secreted 14 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa CRX HGNC:2383 cone-rod homeobox O43186 Nucleus (By similarity). Nucleus (GO:0005634) 12215455 nucleus 49 0 nucleus nucleus Eutheria Euteleostomi Eukaryota CRY1 HGNC:2384 cryptochrome circadian clock 1 Q16526 Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL (By similarity). Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9801304,10428031,14507900,10428031 nucleus 14 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms CRY2 HGNC:2385 cryptochrome circadian clock 2 Q49AN0 Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Extracellular (GO:0005576) 14507900,9801304,10428031,14507900,9801304,16188874 nucleus 13 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Cell.Organisms Cell.Organisms CRYAA HGNC:2388 crystallin, alpha A P02489 Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Nucleus (GO:0005634) 10217480 cytoplasm 37 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms CRYAB HGNC:2389 crystallin, alpha B P02511 Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Nucleus (GO:0005634) 10217480,16049941 cytoplasm 34 0 cytoplasm. nucleus multiple Amniota Bilateria NA CRYBA1 HGNC:2394 crystallin, beta A1 P05813 Nucleus (GO:0005634) 10585769 cytoplasm 24 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms CRYBA2 HGNC:2395 crystallin, beta A2 P53672 Cytoplasm (GO:0005737) 6835373 cytoplasm 23 0 cytoplasm cytoplasm Eutheria Euteleostomi Chordata CRYBA4 HGNC:2396 crystallin, beta A4 P53673 Nucleus (GO:0005634) 8420967 cytoplasm 13 0 nucleus nucleus Theria Euteleostomi Cell.Organisms CRYBB1 HGNC:2397 crystallin, beta B1 P53674 Cytoplasm (GO:0005737) 12506076 cytoplasm 15 0 cytoplasm cytoplasm Eutheria Euteleostomi Cell.Organisms CRYBB2 HGNC:2398 crystallin, beta B2 P43320 Extracellular (GO:0005576) 15146192 cytoplasm 14 0 secreted secreted NA NA Cell.Organisms CRYBB3 HGNC:2400 crystallin, beta B3 P26998 cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CRYBG3 HGNC:34427 beta-gamma crystallin domain containing 3 Q68DQ2 nucleus 49 0 nucleus nucleus Amniota Amniota Cell.Organisms CRYGA HGNC:2408 crystallin, gamma A P11844 cytoplasm 24 0 cytoplasm cytoplasm Theria Theria Cell.Organisms CRYGB HGNC:2409 crystallin, gamma B P07316 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms CRYGC HGNC:2410 crystallin, gamma C P07315 Nucleus (GO:0005634) 3025877 cytoplasm 26 0 nucleus nucleus Euarchontoglires Eutheria Cell.Organisms CRYGD HGNC:2411 crystallin, gamma D P07320 Nucleus (GO:0005634) 3025877 cytoplasm 25 0 nucleus nucleus Eutheria Euteleostomi Cell.Organisms CRYGN HGNC:20458 crystallin, gamma N Q8WXF5 cytoplasm 21 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms CRYGS HGNC:2417 crystallin, gamma S P22914 Nucleus (GO:0005634) 12475213 cytoplasm 24 0 nucleus nucleus Amniota Cell.Organisms Cell.Organisms CRYL1 HGNC:18246 crystallin, lambda 1 Q9Y2S2 Cytoplasm (By similarity). cytoplasm 80 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms CRYM HGNC:2418 crystallin, mu Q14894 Cytoplasm. Cytoplasm (GO:0005737) 12471561,8895318,9328354 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms CRYZ HGNC:2419 crystallin, zeta (quinone reductase) Q08257 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9698072,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms CRYZL1 HGNC:2420 crystallin, zeta (quinone reductase)-like 1 O95825 mitochondrion 9 0 mitochondrion mitochondrion Deuterostomia Deuterostomia Cell.Organisms CS HGNC:2422 citrate synthase O75390 Mitochondrion matrix. Mitochondrial matrix (GO:0005759); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 12198136,15598749,15561729 mitochondrion 100 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms CSAD HGNC:18966 cysteine sulfinic acid decarboxylase Q9Y600 cytoplasm 37 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms CSAG1 HGNC:24294 chondrosarcoma associated gene 1 Q6PB30 secreted 58 0 secreted secreted Human Human NA CSDC2 HGNC:30359 cold shock domain containing C2, RNA binding Q9Y534 Nucleus (By similarity). Cytoplasm (By similarity). Note=PIPPin-RNA complexes are located to the nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10446180,10923677,10446180 cytoplasm 66 0 cytoplasm. nucleus multiple Amniota Euteleostomi Cell.Organisms CSDE1 HGNC:29905 cold shock domain containing E1, RNA-binding O75534 Cytoplasm. Cytoplasm (GO:0005737) 11051545,17081983 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota CSE1L HGNC:2431 CSE1 chromosome segregation 1-like (yeast) P55060 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Mitochondrion (GO:0005739) 9323134,9323134,14718574,15598749 nucleus 7 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota CSF1 HGNC:2432 colony stimulating factor 1 (macrophage) P09603 Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space. Extracellular (GO:0005576) 8086034,1733926,12790839,14634568 secreted 11 1 plasma membrane. secreted multiple Mammalia Euteleostomi Euteleostomi CSF1R HGNC:2433 colony stimulating factor 1 receptor P07333 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2978516 plasma membrane 100 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms CSF2 HGNC:2434 colony stimulating factor 2 (granulocyte-macrophage) P04141 Secreted. Extracellular (GO:0005576) 12022701 secreted 100 0 secreted secreted Eutheria Eutheria Eutheria CSF2RA HGNC:2435 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) P15509 Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted (Probable). Isoform 4: Secreted (Probable). Isoform 6: Secreted (Probable). Cell surface (GO:0009986);Extracellular (GO:0005576) 2555171,12421947/1832774 secreted 72 1 plasma membrane. secreted multiple Amniota Amniota Opisthokonta CSF2RB HGNC:2436 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) P32927 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11207369 secreted 15 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Craniata CSF3 HGNC:2438 colony stimulating factor 3 (granulocyte) P09919 Secreted. Extracellular (GO:0005576) 3034599 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Euteleostomi CSF3R HGNC:2439 colony stimulating factor 3 receptor (granulocyte) Q99062 Isoform 2: Secreted (Probable). Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576);Extracellular (GO:0005576); Lysosome (GO:0005764); Early endosome (GO:0005769); Plasma membrane (GO:0005886) 1701053/1701053,17363902,17363902,2480598 secreted 16 1 endosome. lysosome. plasma membrane. secreted multiple Euteleostomi Euteleostomi Metazoa CSGALNACT1 HGNC:24290 chondroitin sulfate N-acetylgalactosaminyltransferase 1 Q8TDX6 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) golgi apparatus membrane 12 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Holozoa CSGALNACT2 HGNC:24292 chondroitin sulfate N-acetylgalactosaminyltransferase 2 Q8N6G5 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 12446672 golgi apparatus membrane 11 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Holozoa CSH1 HGNC:2440 chorionic somatomammotropin hormone 1 (placental lactogen) P01243 Secreted. Extracellular (GO:0005576) 12682290,6300056 secreted 100 0 secreted secreted Homininae Homininae Cell.Organisms CSH2 HGNC:2441 chorionic somatomammotropin hormone 2 P01243 Secreted. Extracellular (GO:0005576) 1378436 secreted 100 0 secreted secreted NA NA Cell.Organisms CSHL1 HGNC:2442 chorionic somatomammotropin hormone-like 1 Q14406 Secreted. Extracellular (GO:0005576) 2744760 secreted 100 0 secreted secreted Human Human Cell.Organisms CSK HGNC:2444 c-src tyrosine kinase P41240 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic, also present in lipid rafts (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Early endosome (GO:0005769); Late endosome (GO:0005770) 1945408,10918051,15743820,16858407,16858407 plasma membrane 28 0 cytoplasm. endosome multiple Bilateria Bilateria Cell.Organisms CSMD1 HGNC:14026 CUB and Sushi multiple domains 1 Q96PZ7 Membrane; Single-pass type I membrane protein (Potential). secreted 19 1 secreted secreted Euteleostomi Bilateria Cell.Organisms CSMD2 HGNC:19290 CUB and Sushi multiple domains 2 Q7Z408 Cell membrane; Single-pass membrane protein (Potential). secreted 18 1 secreted secreted Euteleostomi Bilateria Cell.Organisms CSMD3 HGNC:19291 CUB and Sushi multiple domains 3 Q7Z407 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12943675 secreted 20 2 n/a n/a Euteleostomi Bilateria Cell.Organisms CSN1S1 HGNC:2445 casein alpha s1 P47710 Secreted. Extracellular (GO:0005576) 9820977 secreted 100 0 secreted secreted Homininae Eutheria Eutheria CSN2 HGNC:2447 casein beta P05814 Secreted. Extracellular (GO:0005576) 2387396 secreted 100 0 secreted secreted Eutheria Eutheria Eutheria CSN3 HGNC:2446 casein kappa P07498 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Eutheria Eutheria CSNK1A1 HGNC:2451 casein kinase 1, alpha 1 P48729 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Nucleoplasm (GO:0005654); Cytoskeleton (GO:0005856); Synaptic vesicle (GO:0008021); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776); Centrosome (GO:0005813); Microtubule (GO:0005874) 10413673,1409656,7622570,1409656,10413673,15635413,1409656,1409656,1409656,15561729 cytoplasm 72 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms CSNK1A1L HGNC:20289 casein kinase 1, alpha 1-like Q8N752 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 66 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CSNK1D HGNC:2452 casein kinase 1, delta P48730 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA- damage. Correct subcellular localization requires kinase activity. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Centrosome (GO:0005813); Golgi apparatus (GO:0005794); Cytoskeleton (GO:0005856); Nucleus (GO:0005634);Nucleus (GO:0005634) 11161704,12270714,17101137,12270714,11161704,12270714,10826492,12270714,10826492,11161704,11161704,10826492,17101137/17081983 cytoplasm 51 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms CSNK1E HGNC:2453 casein kinase 1, epsilon P49674 Cytoplasm (By similarity). Nucleus (By similarity). Cell junction (GO:0030054); Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16616143,12270714,9632646,9632646,17081983 cytoplasm 51 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CSNK1G1 HGNC:2454 casein kinase 1, gamma 1 Q9HCP0 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Cell.Organisms CSNK1G2 HGNC:2455 casein kinase 1, gamma 2 P78368 Cytoplasm. Plasma membrane (GO:0005886) 12062430 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Cell.Organisms CSNK1G3 HGNC:2456 casein kinase 1, gamma 3 Q9Y6M4 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7759525,7759525/17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms CSNK2A1 HGNC:2457 casein kinase 2, alpha 1 polypeptide P68400 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11713579,7896000,1894695,19011756,7896000,2271631,10994779,9525959 cytoplasm 59 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CSNK2A2 HGNC:2459 casein kinase 2, alpha prime polypeptide P19784 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleolus (GO:0005730) 11713579,19011756,7896000,19011756,10994779,15635413 cytoplasm 56 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CSNK2A3 HGNC:2458 casein kinase 2, alpha 3 polypeptide Q8NEV1 cytoplasm 58 0 cytoplasm cytoplasm NA NA NA CSNK2B HGNC:2460 casein kinase 2, beta polypeptide P67870 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2666134,16895915,19011756,2666134,19011756 nucleus 19 0 cytoplasm. nucleus multiple Human Eukaryota NA CSPG4 HGNC:2466 chondroitin sulfate proteoglycan 4 Q6UVK1 Apical cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity). Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side (By similarity). Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). Plasma membrane (GO:0005886) 8790396 plasma membrane 5 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms CSPG5 HGNC:2467 chondroitin sulfate proteoglycan 5 (neuroglycan C) O95196 Cell membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single- pass type I membrane protein (By similarity). Golgi apparatus membrane; Single-pass type I membrane protein (By similarity). Note=In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts (By similarity). Golgi membrane (GO:0000139) 12885772 plasma membrane 51 1 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi Euteleostomi CSPP1 HGNC:26193 centrosome and spindle pole associated protein 1 Q1MSJ5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Associated with mitotic spindles. Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 15580290,16826565,16826565,16826565,16826565 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Eumetazoa CSRNP1 HGNC:14300 cysteine-serine-rich nuclear protein 1 Q96S65 Nucleus (By similarity). Nucleus (GO:0005634) 11526492 nucleus 68 0 nucleus nucleus Eutheria Euteleostomi Eumetazoa CSRNP2 HGNC:16006 cysteine-serine-rich nuclear protein 2 Q9H175 Nucleus (By similarity). nucleus 90 0 nucleus nucleus Eutheria Bilateria Eumetazoa CSRNP3 HGNC:30729 cysteine-serine-rich nuclear protein 3 Q8WYN3 Nucleus (By similarity). nucleus 92 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa CSRP1 HGNC:2469 cysteine and glycine-rich protein 1 P21291 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 12539241,1374386,17081983,9507743,12539241,17081983,11790298 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota CSRP2 HGNC:2470 cysteine and glycine-rich protein 2 Q16527 Nucleus (By similarity). Nucleus (GO:0005634) 8626582 nucleus 99 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota CSRP2BP HGNC:15904 CSRP2 binding protein Q9H8E8 Nucleus. Cytoplasm. Note=Mainly nuclear. Perinuclear region (GO:0048471); Cytosol (GO:0005829) 10924333,10924333 nucleus 35 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms CSRP3 HGNC:2472 cysteine and glycine-rich protein 3 (cardiac LIM protein) P50461 Nucleus (Potential). Cytoplasm. Cytoplasm, cytoskeleton (Potential). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10751147,11113014,9234731,10751147,11113014,9234731 nucleus 63 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota CST1 HGNC:2473 cystatin SN P01037 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 1898352,1471486 secreted 100 0 cytoplasm. secreted multiple Homininae Homininae Eumetazoa CST11 HGNC:15959 cystatin 11 Q9H112 Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in the epididymis. Localized to the postacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm. Extracellular (GO:0005576) 8179826 secreted 19 0 cytoplasm. nucleus. secreted multiple Eutheria Eutheria Euteleostomi CST2 HGNC:2474 cystatin SA P09228 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 1898352,1471486 secreted 100 0 cytoplasm. secreted multiple Human Human Eumetazoa CST3 HGNC:2475 cystatin C P01034 Secreted. Extracellular (GO:0005576) 3495457 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Eumetazoa CST4 HGNC:2476 cystatin S P01036 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 1898352,1471486 secreted 100 0 cytoplasm. secreted multiple Catarrhini Catarrhini Eumetazoa CST5 HGNC:2477 cystatin D P28325 Secreted. Extracellular (GO:0005576) 1939105 secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Eumetazoa CST6 HGNC:2478 cystatin E/M Q15828 Secreted. Extracellular (GO:0005576) 11348457 secreted 100 0 secreted secreted Mammalia Mammalia Eumetazoa CST7 HGNC:2479 cystatin F (leukocystatin) O76096 Secreted. Cytoplasm. Extracellular (GO:0005576); Cytoplasmic vesicle (GO:0016023); Lysosome (GO:0005764) 9632704,12423348,11079561 secreted 21 0 cytoplasm. lysosome. secreted multiple Euteleostomi Euteleostomi Bilateria CST8 HGNC:2480 cystatin 8 (cystatin-related epididymal specific) O60676 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12193387,12193387 secreted 100 0 cytoplasm. secreted multiple Eutheria Eutheria Chordata CST9 HGNC:13261 cystatin 9 (testatin) Q5W186 Secreted. Note=May be targeted through the Golgi via the secretory pathway. Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 12535658,12535658 secreted 100 0 golgi apparatus. secreted multiple Catarrhini Catarrhini Eutheria CST9L HGNC:16233 cystatin 9-like Q9H4G1 Secreted (Potential). secreted 41 0 secreted secreted Eutheria Eutheria Chordata CSTA HGNC:2481 cystatin A (stefin A) P01040 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 6689312,9219725 cytoplasm 100 0 cytoplasm. secreted multiple Eutheria Mammalia Eukaryota CSTB HGNC:2482 cystatin B (stefin B) P04080 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11139332,8014475 cytoplasm 81 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota CSTF1 HGNC:2483 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa Q05048 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 1358884,11790298 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms CSTF2 HGNC:2484 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa P33240 Nucleus. Note=Localized with DDX1 in cleavage bodies. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/8654386,1358884,9736695 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CSTF2T HGNC:17086 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant Q9H0L4 Nucleus (By similarity). Nucleus (GO:0005634) 12408968 nucleus 89 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CSTF3 HGNC:2485 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa Q12996 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1358884,7984242,17081983,7984242 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota CSTL1 HGNC:15958 cystatin-like 1 Q9H114 Secreted (Potential). secreted 18 0 secreted secreted Euarchontoglires Eutheria Bilateria CT45A1 HGNC:33267 cancer/testis antigen family 45, member A1 Q5HYN5 nucleus 18 0 nucleus nucleus NA NA Deuterostomia CT45A2 HGNC:28400 cancer/testis antigen family 45, member A2 Q5DJT8 nucleus 18 0 nucleus nucleus NA NA Deuterostomia CT45A3 HGNC:33268 cancer/testis antigen family 45, member A3 Q8NHU0 nucleus 18 0 nucleus nucleus NA NA NA CT45A4 HGNC:33269 cancer/testis antigen family 45, member A4 Q8N7B7 nucleus 18 0 nucleus nucleus NA NA Deuterostomia CT45A5 HGNC:33270 cancer/testis antigen family 45, member A5 Q6NSH3 nucleus 18 0 nucleus nucleus NA NA Bilateria CT45A6 HGNC:33271 cancer/testis antigen family 45, member A6 Q8N7B7 nucleus 18 0 nucleus nucleus NA NA Deuterostomia CT47A1 HGNC:33282 cancer/testis antigen family 47, member A1 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A10 HGNC:33291 cancer/testis antigen family 47, member A10 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A11 HGNC:27397 cancer/testis antigen family 47, member A11 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A12 HGNC:33292 cancer/testis antigen family 47, member A12 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A2 HGNC:33283 cancer/testis antigen family 47, member A2 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A3 HGNC:33284 cancer/testis antigen family 47, member A3 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A4 HGNC:33285 cancer/testis antigen family 47, member A4 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A5 HGNC:33286 cancer/testis antigen family 47, member A5 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A6 HGNC:33287 cancer/testis antigen family 47, member A6 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A7 HGNC:33288 cancer/testis antigen family 47, member A7 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A8 HGNC:33289 cancer/testis antigen family 47, member A8 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47A9 HGNC:33290 cancer/testis antigen family 47, member A9 Q5JQC4 cytoplasm 41 0 cytoplasm cytoplasm NA NA Boreoeutheria CT47B1 HGNC:33293 cancer/testis antigen family 47, member B1 P0C2W7 endoplasmic reticulum 18 1 endoplasmic reticulum endoplasmic reticulum NA NA Euarchontoglires CT55 HGNC:26047 cancer/testis antigen 55 Q8WUE5 cytoplasm 42 0 cytoplasm cytoplasm Catarrhini Eutheria NA CT62 HGNC:27286 cancer/testis antigen 62 P0C5K7 secreted 62 0 secreted secreted NA NA Primates CT83 HGNC:33494 cancer/testis antigen 83 Q5H943 Cell membrane; Single-pass type II membrane protein. plasma membrane 100 0 plasma membrane plasma membrane Catarrhini Catarrhini NA CTAG1A HGNC:24198 cancer/testis antigen 1A P78358 Cytoplasm. cytoplasm 100 1 cytoplasm cytoplasm Catarrhini Catarrhini NA CTAG1B HGNC:2491 cancer/testis antigen 1B P78358 Cytoplasm. Cytoplasm (GO:0005737) 10901371,17137291 cytoplasm 100 1 cytoplasm cytoplasm Catarrhini Catarrhini Eutheria CTAG2 HGNC:2492 cancer/testis antigen 2 O75638 Plasma membrane (GO:0005886) cytoplasm 71 0 cytoplasm cytoplasm Human Human NA CTAGE1 HGNC:24346 cutaneous T-cell lymphoma-associated antigen 1 Q96RT6 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 12 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Catarrhini Bilateria CTAGE15 HGNC:37295 CTAGE family, member 15 A4D2H0 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 12 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA NA CTAGE4 HGNC:24772 CTAGE family, member 4 Q8IX94 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 12 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eumetazoa CTAGE5 HGNC:7057 CTAGE family, member 5 O15320 Cytoplasm (GO:0005737); Integral to membrane (GO:0016021);Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Nucleus (GO:0005634) 11803467,11803467/11803467,17081983,11803467,17081983 endoplasmic reticulum membrane 13 1 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Metazoa CTAGE6 HGNC:28644 CTAGE family, member 6 Q86UF2 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 12 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia NA CTAGE9 HGNC:37275 CTAGE family, member 9 A4FU28 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 13 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Bilateria CTBP1 HGNC:2494 C-terminal binding protein 1 Q13363 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11864595,10764811,16724116,11864595,16724116 nucleus 65 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms CTBP2 HGNC:2495 C-terminal binding protein 2 P56545 Nucleus (Potential). Cell junction, synapse (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11864595,11864595 nucleus 67 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms CTBS HGNC:2496 chitobiase, di-N-acetyl- Q01459 Lysosome. Lysosome (GO:0005764) 1527079 secreted 14 0 lysosome lysosome Euteleostomi Cell.Organisms Cell.Organisms CTC1 HGNC:26169 CTS telomere maintenance complex component 1 Q2NKJ3 Nucleus. Chromosome, telomere. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo. nucleus 100 1 nucleus nucleus Amniota Euteleostomi Chordata CTCF HGNC:13723 CCCTC-binding factor (zinc finger protein) P49711 Nucleus, nucleoplasm. Chromosome. Chromosome, centromere. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase. Nucleus (GO:0005634) 12878173,12099698 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota CTCFL HGNC:16234 CCCTC-binding factor (zinc finger protein)-like Q8NI51 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12011441,12011441 nucleus 36 0 cytoplasm. nucleus multiple Mammalia Bilateria Eukaryota CTDNEP1 HGNC:19085 CTD nuclear envelope phosphatase 1 O95476 Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Integral to membrane (GO:0016021) nucleus 34 0 endoplasmic reticulum membrane. nucleus membrane multiple Theria Eukaryota Cell.Organisms CTDP1 HGNC:2498 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 Q9Y5B0 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively. Nucleus (GO:0005634);Cytoplasm (GO:0005737) 9765293/17081983 nucleus 17 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CTDSP1 HGNC:21614 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Q9GZU7 Nucleus. Note=Colocalizes with RNA polymerase II. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,12721286,19004823,,,19004823, nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CTDSP2 HGNC:17077 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 O14595 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,,19004823,,,19004823, nucleus 54 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CTDSPL HGNC:16890 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like O15194 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) ,19004823,,,19004823,/15051889 nucleus 64 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms CTDSPL2 HGNC:26936 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 Q05D32 Nucleus (GO:0005634) 17081983 nucleus 32 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CTF1 HGNC:2499 cardiotrophin 1 Q16619 Secreted. Extracellular (GO:0005576) 8755479 secreted 100 0 secreted secreted Mammalia Mammalia Amniota CTGF HGNC:2500 connective tissue growth factor P29279 Secreted, extracellular space, extracellular matrix (By similarity). Secreted (By similarity). Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 11697887,11697887,11502477 secreted 90 0 golgi apparatus. secreted multiple Chordata Bilateria Bilateria CTH HGNC:2501 cystathionase (cystathionine gamma-lyase) P32929 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CTHRC1 HGNC:18831 collagen triple helix repeat containing 1 Q96CG8 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 15618538 secreted 93 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms CTIF HGNC:23925 CBP80/20-dependent translation initiation factor O43310 Cytoplasm, perinuclear region. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Euteleostomi Metazoa CTLA4 HGNC:2505 cytotoxic T-lymphocyte-associated protein 4 P16410 Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cell surface (GO:0009986) 9724847,7559643,17220876 plasma membrane 100 1 cytoplasm. plasma membrane multiple Amniota Euteleostomi Euteleostomi CTNNA1 HGNC:2509 catenin (cadherin-associated protein), alpha 1, 102kDa P35221 Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cell junction (GO:0030054) 1924379,7954478,1924379,17057644,7542250 secreted 27 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa CTNNA2 HGNC:2510 catenin (cadherin-associated protein), alpha 2 P26232 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, adherens junction (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, axon (By similarity). Note=Recruited to the nucleus upon ZNF639 overexpression. Cytoplasm (GO:0005737) 1638632 secreted 27 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa CTNNA3 HGNC:2511 catenin (cadherin-associated protein), alpha 3 Q9UI47 Cytoplasm, cytoskeleton (Potential). Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Plasma membrane (GO:0005886) 11590244 secreted 24 0 secreted secreted Bilateria Bilateria Holozoa CTNNAL1 HGNC:2512 catenin (cadherin-associated protein), alpha-like 1 Q9UBT7 Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) 12270917 secreted 6 1 cytoplasm cytoplasm Bilateria Bilateria Holozoa CTNNB1 HGNC:2514 catenin (cadherin-associated protein), beta 1, 88kDa P35222 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta- catenin is localized to the cell membrane. In interphase, colocalizes with CRO between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CRO and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CRO. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Basolateral membrane (GO:0016323); Perinuclear region (GO:0048471); Cell junction (GO:0030054); Cytoskeleton (GO:0005856);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,12107263,10980707,17289029,16357527,7954478,15574752,12740383,17092940,,,12107263,10980707,10896949,17289029,16357527,17377531,12750561,15574752,12740383,17092940,,,10816572,11157977,11035789,15684397,12740383,17914462,,16103886,15811349,15684397,17057644,7542250,9405455,15684397,,12740383,/17081983,17081983 secreted 24 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CTNNBIP1 HGNC:16913 catenin, beta interacting protein 1 Q9NSA3 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14613891,10898789,14613891,10898789,12927518 cytoplasm 28 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa CTNNBL1 HGNC:15879 catenin, beta like 1 Q8WYA6 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12659813,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota CTNND1 HGNC:2515 catenin (cadherin-associated protein), delta 1 O60716 Cytoplasm. Nucleus. Cell membrane. Isoform 1A: Nucleus. Isoform 2A: Nucleus. Isoform 3A: Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983,17081983/9774455,12740216,17215244,17081983,10393933,11181067,17081983 nucleus 20 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota CTNND2 HGNC:2516 catenin (cadherin-associated protein), delta 2 Q9UQB3 Nucleus (By similarity). Cell junction, adherens junction (By similarity). Perikaryon. Note=Co-localizes with CDK5 in the cell body of neuronal cells. Plasma membrane (GO:0005886) 10673328,10037471 secreted 26 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota CTNS HGNC:2518 cystinosin, lysosomal cystine transporter O60931 Lysosome membrane; Multi-pass membrane protein. Lysosome (GO:0005764); Plasma membrane (GO:0005886) 12204010,11150305 plasma membrane 47 7 lysosome. lysosome membrane. plasma membrane multiple Bilateria Eukaryota Eukaryota CTPS1 HGNC:2519 CTP synthase 1 P17812 Cytoplasm (GO:0005737) 3355843 cytoplasm 48 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CTPS2 HGNC:2520 CTP synthase 2 Q9NRF8 cytoplasm 45 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CTR9 HGNC:16850 CTR9, Paf1/RNA polymerase II complex component Q6PD62 Nucleus speckle (By similarity). Note=Found in speckles (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8636124,17081983,17081983 nucleus 97 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms CTRB1 HGNC:2521 chymotrypsinogen B1 P17538 Secreted, extracellular space. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Zymogen granule (GO:0042588) 511932,511932,16278343 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Chordata Chordata Cell.Organisms CTRB2 HGNC:2522 chymotrypsinogen B2 Q6GPI1 Secreted, extracellular space. secreted 100 0 secreted secreted Chordata Chordata Cell.Organisms CTRC HGNC:2523 chymotrypsin C (caldecrin) Q99895 Extracellular (GO:0005576); Zymogen granule (GO:0042588) 9538241,16278343 secreted 54 0 secreted secreted Chordata Bilateria Cell.Organisms CTRL HGNC:2524 chymotrypsin-like P40313 Extracellular (GO:0005576) 12231569 secreted 48 0 secreted secreted Amniota Euteleostomi Cell.Organisms CTSA HGNC:9251 cathepsin A P10619 Lysosome. Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 9105659,3084261,1387645,3084261,14718574 secreted 22 0 endoplasmic reticulum. golgi apparatus. lysosome. secreted multiple Eukaryota Eukaryota Cell.Organisms CTSB HGNC:2527 cathepsin B P07858 Lysosome. Melanosome. Secreted, extracellular space (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Perinuclear region (GO:0048471); Mitochondrion (GO:0005739); Lysosome (GO:0005764); Nuclear membrane (GO:0005635); Endoplasmic reticulum (GO:0005783); Zymogen granule (GO:0042588) 9539769,11932257,9360997,11139332,12186841,11016923,11746262,8014475,11932257,1984484,11228542,9776083,9412840,12589965,15679122,15710602,8014475,15679122,11815600,15262981,9582368,8014475,16364318,8014475,11932257,11932257 vacuole 21 0 cytoplasm. endoplasmic reticulum. lysosome. melanosome. mitochondrion. nucleus membrane. secreted multiple Bilateria Eukaryota Cell.Organisms CTSC HGNC:2528 cathepsin C P53634 Lysosome. Lysosome (GO:0005764); Mitochondrion (GO:0005739) 11327826,15598749 secreted 21 0 lysosome. mitochondrion multiple Deuterostomia Eukaryota Cell.Organisms CTSD HGNC:2529 cathepsin D P07339 Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). Lysosome (GO:0005764); Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 11687971,10986284,16188874,10748089,6236213,6236213,8106429,15598749 secreted 34 0 endoplasmic reticulum. golgi apparatus. lysosome. melanosome. mitochondrion. secreted multiple Eukaryota Eukaryota Eukaryota CTSE HGNC:2530 cathepsin E P14091 Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. Endoplasmic reticulum (GO:0005783); Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8491674,8491674,8346912,1794985,1794985 secreted 44 0 cytoplasm. endoplasmic reticulum. endosome. nucleus multiple Tetrapoda Tetrapoda NA CTSF HGNC:2531 cathepsin F Q9UBX1 Lysosome. Lysosome (GO:0005764) 9822672 secreted 28 0 lysosome lysosome Eukaryota Eukaryota Cell.Organisms CTSG HGNC:2532 cathepsin G P08311 Cell surface. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Lysosome (GO:0005764); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 11241273,9536127,2164060,11945165,1452887,11259672,9412840 cytoplasm 44 0 cytoplasm. golgi apparatus. lysosome. secreted multiple Euteleostomi Euteleostomi Cell.Organisms CTSH HGNC:2535 cathepsin H P09668 Lysosome. Microsome (GO:0005792); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Lysosome (GO:0005764) 11796715,11796715,11796715,11796715 vacuole 35 0 lysosome. mitochondrion. nucleus multiple Chordata Eukaryota Cell.Organisms CTSK HGNC:2536 cathepsin K P43235 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576) 9143502,8647860 secreted 38 0 lysosome. secreted multiple Euteleostomi Cell.Organisms Cell.Organisms CTSL HGNC:2537 cathepsin L P07711 Lysosome. Endosome (GO:0005768); Lysosome (GO:0005764) 12437117,10849756,12437117 secreted 52 0 endosome. lysosome multiple Eukaryota Eukaryota Cell.Organisms CTSO HGNC:2542 cathepsin O P43234 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576) 7929457,7929457 secreted 27 0 lysosome. secreted multiple NA NA NA CTSS HGNC:2545 cathepsin S P25774 Lysosome. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Lysosome (GO:0005764); Extracellular (GO:0005576); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12164923,,11710834,15985526,,9099979,7717452,9524075,9545324,7575468,12643447,12643447 secreted 40 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome. secreted multiple Eukaryota Eukaryota Cell.Organisms CTSV HGNC:2538 cathepsin V O60911 Lysosome (Potential). Lysosome (GO:0005764) 12925692 secreted 51 0 lysosome lysosome Eukaryota Eukaryota Cell.Organisms CTSW HGNC:2546 cathepsin W P56202 Endoplasmic reticulum (GO:0005783) 11490002 secreted 22 0 endoplasmic reticulum endoplasmic reticulum Mammalia Tetrapoda Cell.Organisms CTSZ HGNC:2547 cathepsin Z Q9UBR2 Lysosome. Lysosome (GO:0005764) 9642240 secreted 85 0 lysosome lysosome Euteleostomi Eukaryota Cell.Organisms CTTN HGNC:3338 cortactin Q14247 Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856); Clathrin-coated vesicle (GO:0030136);Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 8474448,13129922,8474448,17318189/8474448,8474448 cytoplasm 45 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota CTTNBP2 HGNC:15679 cortactin binding protein 2 Q8WZ74 Cytoplasm, cell cortex (By similarity). Cell projection, dendritic spine (By similarity). Note=Remains associated with dendritic spines even after glutamate stimulation (By similarity). cytoplasm 31 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms CTTNBP2NL HGNC:25330 CTTNBP2 N-terminal like Q9P2B4 Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with stress fibers (By similarity). cytoplasm 87 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa CTU1 HGNC:29590 cytosolic thiouridylase subunit 1 Q7Z7A3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms CTU2 HGNC:28005 cytosolic thiouridylase subunit 2 homolog (S. pombe) Q2VPK5 Cytoplasm. Cytoplasm (GO:0005737) 17081983 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms CTXN1 HGNC:31108 cortexin 1 P60606 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 25 1 plasma membrane plasma membrane Amniota Euteleostomi Euteleostomi CTXN2 HGNC:31109 cortexin 2 P0C2S0 Membrane; Single-pass membrane protein (Potential). plasma membrane 26 1 plasma membrane plasma membrane NA NA Euteleostomi CTXN3 HGNC:31110 cortexin 3 Q4LDR2 Membrane; Single-pass membrane protein (Potential). plasma membrane 18 1 plasma membrane plasma membrane Mammalia Euteleostomi Craniata CUBN HGNC:2548 cubilin (intrinsic factor-cobalamin receptor) O60494 Endosome membrane; Peripheral membrane protein (By similarity). Lysosome membrane; Peripheral membrane protein (By similarity). Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity). Plasma membrane (GO:0005886) 9572993 secreted 24 0 secreted secreted Bilateria Bilateria Cell.Organisms CUEDC1 HGNC:31350 CUE domain containing 1 Q9NWM3 Endoplasmic reticulum (GO:0005783) nucleus 88 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa CUEDC2 HGNC:28352 CUE domain containing 2 Q9H467 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17347654,17347654 nucleus 62 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa CUL1 HGNC:2551 cullin 1 Q13616 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11027288,11027288 cytoplasm 29 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CUL2 HGNC:2552 cullin 2 Q13617 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9122164,19037258 cytoplasm 18 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota CUL3 HGNC:2553 cullin 3 Q13618 Nucleus. Golgi apparatus. Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 10500095,10500095 nucleus 28 0 golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota CUL4A HGNC:2554 cullin 4A Q13619 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 11673459,,11673459,18593899,,,18593899, nucleus 79 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota CUL4B HGNC:2555 cullin 4B Q13620 Nucleus. Nucleus (GO:0005634) ,10092517,17392787,18593899, nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota CUL5 HGNC:2556 cullin 5 Q93034 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11409851,11409851,12917106,19037258 nucleus 11 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota CUL7 HGNC:21024 cullin 7 Q14999 Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Co-localizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. cytoplasm 56 0 cytoplasm. golgi apparatus multiple Tetrapoda Euteleostomi Holozoa CUL9 HGNC:15982 cullin 9 Q8IWT3 Cytoplasm. Cytoplasm (GO:0005737) 12526791 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota CUTA HGNC:21101 cutA divalent cation tolerance homolog (E. coli) O60888 Plasma membrane (GO:0005886) 10800960 mitochondrion 32 0 mitochondrion mitochondrion Bilateria Cell.Organisms NA CUTC HGNC:24271 cutC copper transporter Q9NTM9 Cytoplasm. Nucleus. Note=The overexpressed protein is detected in the cytoplasm, and depending on the cell line, also in the nucleus. Nucleolus (GO:0005730) 15635413 cytoplasm 53 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms CUX1 HGNC:2557 cut-like homeobox 1 P39880 Nucleus. Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 9792700,11403998,19059367,12429822 nucleus 100 0 golgi apparatus. nucleus multiple NA NA NA CUX2 HGNC:19347 cut-like homeobox 2 O14529 Nucleus (By similarity). Nucleus (GO:0005634) 8798433 nucleus 81 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota CUZD1 HGNC:17937 CUB and zona pellucida-like domains 1 Q86UP6 Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Associated with zymogen granule membranes (By similarity). Plasma membrane (GO:0005886) 11416020 secreted 25 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa CWC15 HGNC:26939 CWC15 spliceosome-associated protein homolog (S. cerevisiae) Q9P013 Nucleus. Nucleus (GO:0005634) 10873569 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota NA CWC22 HGNC:29322 CWC22 spliceosome-associated protein homolog (S. cerevisiae) Q9HCG8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota CWC25 HGNC:25989 CWC25 spliceosome-associated protein homolog (S. cerevisiae) Q9NXE8 Nucleus (GO:0005634) 17081983 nucleus 24 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota CWC27 HGNC:10664 CWC27 spliceosome-associated protein homolog (S. cerevisiae) Q6UX04 nucleus 36 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms CWF19L1 HGNC:25613 CWF19-like 1, cell cycle control (S. pombe) Q69YN2 nucleus 14 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms CWF19L2 HGNC:26508 CWF19-like 2, cell cycle control (S. pombe) Q2TBE0 nucleus 10 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota CWH43 HGNC:26133 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) Q9H720 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 17 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eukaryota Cell.Organisms CX3CL1 HGNC:10647 chemokine (C-X3-C motif) ligand 1 P78423 Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11495925,9726990,10458770,12100035,11495925,12714508,12667665,12042278 secreted 35 1 plasma membrane. secreted multiple Mammalia Mammalia Euteleostomi CX3CR1 HGNC:2558 chemokine (C-X3-C motif) receptor 1 P49238 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9390561 plasma membrane 100 7 plasma membrane plasma membrane Amniota Amniota Eumetazoa CXADR HGNC:2559 coxsackie virus and adenovirus receptor P78310 Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Basolateral cell membrane; Single-pass membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9096397,12021372,12021372,15598749 plasma membrane 19 1 cytoplasm. mitochondrion. plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa CXCL1 HGNC:4602 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) P09341 Secreted. Extracellular (GO:0005576) 10881932,2670560,2182761,8942852,8597869 secreted 100 0 secreted secreted Mammalia Mammalia Craniata CXCL10 HGNC:10637 chemokine (C-X-C motif) ligand 10 P02778 Secreted. Extracellular (GO:0005576) 12930373,9022006 secreted 100 0 secreted secreted Mammalia Mammalia Craniata CXCL11 HGNC:10638 chemokine (C-X-C motif) ligand 11 O14625 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10233762,9370294,10233762 secreted 100 0 cytoplasm. secreted multiple Euarchontoglires Euteleostomi Craniata CXCL12 HGNC:10672 chemokine (C-X-C motif) ligand 12 P48061 Secreted. Extracellular (GO:0005576) 10550315 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Euteleostomi CXCL13 HGNC:10639 chemokine (C-X-C motif) ligand 13 O43927 Secreted. Extracellular (GO:0005576) 12406091 secreted 100 0 secreted secreted Eutheria Amniota Craniata CXCL14 HGNC:10640 chemokine (C-X-C motif) ligand 14 O95715 Secreted. secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata CXCL16 HGNC:16642 chemokine (C-X-C motif) ligand 16 Q9H2A7 Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Also exists as a soluble form. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 15128827,15128827 secreted 56 1 plasma membrane. secreted multiple Eutheria Mammalia Mammalia CXCL17 HGNC:19232 chemokine (C-X-C motif) ligand 17 Q6UXB2 Secreted. secreted 100 0 secreted secreted Eutheria Eutheria Eutheria CXCL2 HGNC:4603 chemokine (C-X-C motif) ligand 2 P19875 Secreted. Extracellular (GO:0005576) 2643119,12508094,12419803,11559650 secreted 100 0 secreted secreted Mammalia Mammalia Craniata CXCL3 HGNC:4604 chemokine (C-X-C motif) ligand 3 P19876 Secreted. Extracellular (GO:0005576) 8344798 secreted 100 0 secreted secreted Homininae Homininae Craniata CXCL5 HGNC:10642 chemokine (C-X-C motif) ligand 5 P42830 Secreted. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 9365115,8083342,1744577 secreted 100 0 endoplasmic reticulum. secreted multiple Theria Theria Craniata CXCL6 HGNC:10643 chemokine (C-X-C motif) ligand 6 P80162 Secreted. Extracellular (GO:0005576) 12533683,12524079,9057843 secreted 100 0 secreted secreted Theria Theria Craniata CXCL9 HGNC:7098 chemokine (C-X-C motif) ligand 9 Q07325 Secreted. Extracellular (GO:0005576) 12856973,11423172,8476424 secreted 100 0 secreted secreted Theria Theria Craniata CXCR1 HGNC:6026 chemokine (C-X-C motif) receptor 1 P25024 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1840701 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa CXCR2 HGNC:6027 chemokine (C-X-C motif) receptor 2 P25025 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endosome (GO:0005768) 11170396,11170396,10688807 plasma membrane 100 7 cytoplasm. endosome. plasma membrane multiple Amniota Euteleostomi Eumetazoa CXCR3 HGNC:4540 chemokine (C-X-C motif) receptor 3 P49682 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8666380,12750173,10741397 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Euteleostomi Eumetazoa CXCR4 HGNC:2561 chemokine (C-X-C motif) receptor 4 P61073 Cell membrane; Multi-pass membrane protein. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737);Integral to plasma membrane (GO:0005887); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12609846,12433920,11668182,14973260,11668182,14973260/12421915,17081983,17081983 plasma membrane 100 7 cytoplasm. nucleus. plasma membrane multiple Chordata Chordata Metazoa CXCR5 HGNC:1060 chemokine (C-X-C motif) receptor 5 P32302 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa CXCR6 HGNC:16647 chemokine (C-X-C motif) receptor 6 O00574 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Tetrapoda Metazoa CXorf21 HGNC:25667 chromosome X open reading frame 21 Q9HAI6 nucleus 42 0 nucleus nucleus Theria Tetrapoda Craniata CXorf22 HGNC:28546 chromosome X open reading frame 22 Q6ZTR5 secreted 29 0 secreted secreted Deuterostomia Deuterostomia Eukaryota CXorf23 HGNC:27413 chromosome X open reading frame 23 A2AJT9 Mitochondrion (Potential). Nucleus (GO:0005634) 17081983 nucleus 21 0 nucleus nucleus Mammalia Mammalia Euteleostomi CXorf24 HGNC:27333 chromosome X open reading frame 24 Q8TB33 secreted 22 0 secreted secreted Homininae Homininae Eutheria CXorf27 HGNC:18417 chromosome X open reading frame 27 O75409 nucleus 77 0 nucleus nucleus Euarchontoglires Eutheria Euarchontoglires CXorf30 HGNC:27298 chromosome X open reading frame 30 A6PW82 mitochondrion 18 0 mitochondrion mitochondrion Deuterostomia Eukaryota NA CXorf36 HGNC:25866 chromosome X open reading frame 36 Q9H7Y0 Secreted (Potential). secreted 74 0 secreted secreted Amniota Chordata Eumetazoa CXorf38 HGNC:28589 chromosome X open reading frame 38 Q8TB03 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 43 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa CXorf40A HGNC:28089 chromosome X open reading frame 40A Q8TE69 cytoplasm 32 0 cytoplasm cytoplasm Tetrapoda Euteleostomi NA CXorf40B HGNC:17402 chromosome X open reading frame 40B Q96DE9 cytoplasm 30 0 cytoplasm cytoplasm Tetrapoda Euteleostomi NA CXorf49 HGNC:30891 chromosome X open reading frame 49 A8MYA2 nucleus 73 0 nucleus nucleus Eutheria Eutheria NA CXorf49B HGNC:34229 chromosome X open reading frame 49B A8MYA2 nucleus 73 0 nucleus nucleus Eutheria Eutheria NA CXorf56 HGNC:26239 chromosome X open reading frame 56 Q9H5V9 nucleus 42 1 nucleus nucleus Bilateria Eukaryota Eukaryota CXorf57 HGNC:25486 chromosome X open reading frame 57 Q6NSI4 nucleus 60 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa CXorf58 HGNC:26356 chromosome X open reading frame 58 Q96LI9 nucleus 64 0 nucleus nucleus Theria Deuterostomia Eukaryota CXorf64 HGNC:34498 chromosome X open reading frame 64 B1ATL7 nucleus 60 0 nucleus nucleus Eutheria Eutheria Eutheria CXorf65 HGNC:33713 chromosome X open reading frame 65 A6NEN9 nucleus 70 1 nucleus nucleus Eutheria Deuterostomia Eumetazoa CXorf66 HGNC:33743 chromosome X open reading frame 66 Q5JRM2 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 76 1 secreted secreted Eutheria Eutheria Eutheria CXorf67 HGNC:33738 chromosome X open reading frame 67 Q86X51 nucleus 11 0 nucleus nucleus Catarrhini Eutheria NA CXXC1 HGNC:24343 CXXC finger protein 1 Q9P0U4 Nucleus speckle. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes. Nucleus (GO:0005634) 10688657 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota CXXC4 HGNC:24593 CXXC finger protein 4 Q9H2H0 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11113207 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Euteleostomi Metazoa CXXC5 HGNC:26943 CXXC finger protein 5 Q7LFL8 Nucleus. Cytoplasm (By similarity). Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane (By similarity). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Amniota Euteleostomi Metazoa CYB561 HGNC:2571 cytochrome b561 P49447 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Secretory vesicle (None); Mitochondrion (GO:0005739) 7980462,7096323,7980462,12837283 vacuole membrane 23 6 mitochondrion mitochondrion Theria Eukaryota Eukaryota CYB561A3 HGNC:23014 cytochrome b561 family, member A3 Q8NBI2 Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein. vacuole membrane 21 6 lysosome membrane lysosome membrane Amniota Eukaryota Eukaryota CYB561D1 HGNC:26804 cytochrome b561 family, member D1 Q8N8Q1 Membrane; Multi-pass membrane protein (Probable). vacuole membrane 4 6 vacuole membrane vacuole membrane Theria Deuterostomia Eukaryota CYB561D2 HGNC:30253 cytochrome b561 family, member D2 O14569 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 11085536 golgi apparatus membrane 56 6 plasma membrane plasma membrane Chordata Eukaryota Holozoa CYB5A HGNC:2570 cytochrome b5 type A (microsomal) P00167 Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side. Isoform 2: Cytoplasm. Mitochondrion (GO:0005739) 7649306,9813010,15598749 endoplasmic reticulum membrane 24 1 cytoplasm. endoplasmic reticulum membrane. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms CYB5B HGNC:24374 cytochrome b5 type B (outer mitochondrial membrane) O43169 Mitochondrion outer membrane (By similarity). Mitochondrion (GO:0005739) 14739275 endoplasmic reticulum membrane 29 1 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms CYB5D1 HGNC:26516 cytochrome b5 domain containing 1 Q6P9G0 mitochondrion 25 0 mitochondrion mitochondrion Mammalia Eukaryota Eukaryota CYB5D2 HGNC:28471 cytochrome b5 domain containing 2 Q8WUJ1 Secreted (By similarity). secreted 76 0 secreted secreted Bilateria Eukaryota Eukaryota CYB5R1 HGNC:13397 cytochrome b5 reductase 1 Q9UHQ9 Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 10611283,10611283 mitochondrion 34 1 cytoplasm. endoplasmic reticulum multiple Eukaryota Cell.Organisms Cell.Organisms CYB5R2 HGNC:24376 cytochrome b5 reductase 2 Q6BCY4 Endoplasmic reticulum membrane (GO:0005789); Cytosol (GO:0005829) 10611283,15858218 mitochondrion membrane 27 1 cytoplasm. endoplasmic reticulum membrane multiple Eukaryota Cell.Organisms Cell.Organisms CYB5R3 HGNC:2873 cytochrome b5 reductase 3 P00387 Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side. Isoform 2: Cytoplasm. Note=Produces the soluble form found in erythrocytes. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8978818,8978818,15598749,9207238,9207238,9639531 mitochondrion membrane 31 2 cytoplasm. endoplasmic reticulum. mitochondrion. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms CYB5R4 HGNC:20147 cytochrome b5 reductase 4 Q7L1T6 Endoplasmic reticulum. Note=Soluble protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 15131110,10611283 endoplasmic reticulum 100 1 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Cell.Organisms CYB5RL HGNC:32220 cytochrome b5 reductase-like Q6IPT4 mitochondrion membrane 15 2 mitochondrion membrane mitochondrion membrane Theria Bilateria Cell.Organisms CYBA HGNC:2577 cytochrome b-245, alpha polypeptide P13498 Cell membrane. Plasma membrane (GO:0005886); Lysosome (GO:0005764) 12121978,12121978 plasma membrane 28 4 lysosome. plasma membrane multiple Euteleostomi Eukaryota Holozoa CYBB HGNC:2578 cytochrome b-245, beta polypeptide P04839 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2243141 plasma membrane 100 8 plasma membrane plasma membrane Deuterostomia Eukaryota NA CYBRD1 HGNC:20797 cytochrome b reductase 1 Q53TN4 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11230685,17081983 vacuole membrane 20 6 nucleus. plasma membrane multiple Human Eukaryota Eukaryota CYC1 HGNC:2579 cytochrome c-1 P08574 Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side. Mitochondrion (GO:0005739) 8188279,15598749 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Theria Eukaryota Cell.Organisms CYCS HGNC:19986 cytochrome c, somatic P99999 Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 2580882,17510655,11285261,16413544,12624108,11448953,15598749,,10622714,11285261,,12624108 mitochondrion 100 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms CYFIP1 HGNC:13759 cytoplasmic FMR1 interacting protein 1 Q7L576 Cytoplasm, perinuclear region (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11438699,11438699 cytoplasm 59 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota CYFIP2 HGNC:13760 cytoplasmic FMR1 interacting protein 2 Q96F07 Cytoplasm. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. Cytoplasm (GO:0005737); Synapse (GO:0045202) 11438699,11438699 cytoplasm 60 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota CYGB HGNC:16505 cytoglobin Q8WWM9 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14660570,12796507,12796507 cytoplasm 92 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms CYHR1 HGNC:17806 cysteine/histidine-rich 1 Q6ZMK1 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Shows a prominent perinuclear and cytoplasmic localization (By similarity). Integral to membrane (GO:0016021) cytoplasm 95 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota CYLC1 HGNC:2582 cylicin, basic protein of sperm head cytoskeleton 1 P35663 Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure. cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Eutheria Mammalia CYLC2 HGNC:2583 cylicin, basic protein of sperm head cytoskeleton 2 Q14093 Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure. Cytoplasm (GO:0005737) 7737358 cytoplasm 100 0 cytoplasm cytoplasm Human Human Mammalia CYLD HGNC:2584 cylindromatosis (turban tumor syndrome) Q9NQC7 Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. Nucleus (GO:0005634);Cytoplasm (GO:0005737) 10835629/17081983 cytoplasm 40 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa CYorf17 HGNC:38732 chromosome Y open reading frame 17 Q9H606 secreted 50 0 secreted secreted Homininae Homininae Primates CYP11A1 HGNC:2590 cytochrome P450, family 11, subfamily A, polypeptide 1 P05108 Mitochondrion membrane. Mitochondrion (GO:0005739) 10856721 mitochondrion 14 0 mitochondrion mitochondrion Chordata Chordata Cell.Organisms CYP11B1 HGNC:2591 cytochrome P450, family 11, subfamily B, polypeptide 1 P15538 Mitochondrion membrane. Mitochondrion (GO:0005739) 2592361,7903314 mitochondrion 12 0 mitochondrion mitochondrion Mammalia Chordata Cell.Organisms CYP11B2 HGNC:2592 cytochrome P450, family 11, subfamily B, polypeptide 2 P19099 Mitochondrion membrane. Mitochondrion (GO:0005739) 12137808 mitochondrion 11 0 mitochondrion mitochondrion Mammalia Chordata Cell.Organisms CYP17A1 HGNC:2593 cytochrome P450, family 17, subfamily A, polypeptide 1 P05093 Membrane (Potential). Endoplasmic reticulum (GO:0005783) 9326943 endoplasmic reticulum membrane 13 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Cell.Organisms CYP19A1 HGNC:2594 cytochrome P450, family 19, subfamily A, polypeptide 1 P11511 Membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11469726,11997208 endoplasmic reticulum membrane 5 2 cytoplasm. endoplasmic reticulum multiple Euteleostomi Euteleostomi Cell.Organisms CYP1A1 HGNC:2595 cytochrome P450, family 1, subfamily A, polypeptide 1 P04798 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11792676,8442765,17081983 endoplasmic reticulum membrane 9 4 endoplasmic reticulum. nucleus multiple Deuterostomia Eukaryota Cell.Organisms CYP1A2 HGNC:2596 cytochrome P450, family 1, subfamily A, polypeptide 2 P05177 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 8573198 endoplasmic reticulum membrane 9 3 endoplasmic reticulum endoplasmic reticulum Deuterostomia Eukaryota Cell.Organisms CYP1B1 HGNC:2597 cytochrome P450, family 1, subfamily B, polypeptide 1 Q16678 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 8175734,11452143 endoplasmic reticulum membrane 7 4 cytoplasm. endoplasmic reticulum multiple Euteleostomi Eukaryota Cell.Organisms CYP20A1 HGNC:20576 cytochrome P450, family 20, subfamily A, polypeptide 1 Q6UW02 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 6 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Deuterostomia Cell.Organisms CYP21A2 HGNC:2600 cytochrome P450, family 21, subfamily A, polypeptide 2 P08686 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) 8485582 endoplasmic reticulum 12 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA CYP24A1 HGNC:2602 cytochrome P450, family 24, subfamily A, polypeptide 1 Q07973 Mitochondrion. Mitochondrion (GO:0005739) 10218951 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Opisthokonta Cell.Organisms CYP26A1 HGNC:2603 cytochrome P450, family 26, subfamily A, polypeptide 1 O43174 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783);Endoplasmic reticulum (GO:0005783) 9228017,8601734/9228017 endoplasmic reticulum membrane 13 1 endoplasmic reticulum endoplasmic reticulum Euteleostomi Cell.Organisms Cell.Organisms CYP26B1 HGNC:20581 cytochrome P450, family 26, subfamily B, polypeptide 1 Q9NR63 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 10823918 endoplasmic reticulum membrane 12 2 endoplasmic reticulum endoplasmic reticulum Deuterostomia Eukaryota Cell.Organisms CYP26C1 HGNC:20577 cytochrome P450, family 26, subfamily C, polypeptide 1 Q6V0L0 Membrane; Single-pass membrane protein (Potential). Microsome (GO:0005792) 14532297 endoplasmic reticulum membrane 13 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Cell.Organisms CYP27A1 HGNC:2605 cytochrome P450, family 27, subfamily A, polypeptide 1 Q02318 Mitochondrion membrane. Mitochondrion (GO:0005739) 11604260 mitochondrion 18 0 mitochondrion mitochondrion Euteleostomi Bilateria Cell.Organisms CYP27B1 HGNC:2606 cytochrome P450, family 27, subfamily B, polypeptide 1 O15528 Mitochondrion membrane. Mitochondrion (GO:0005739) 9428799 mitochondrion 18 0 mitochondrion mitochondrion Theria Euteleostomi Cell.Organisms CYP27C1 HGNC:33480 cytochrome P450, family 27, subfamily C, polypeptide 1 Q4G0S4 Membrane (Potential). mitochondrion 17 2 mitochondrion mitochondrion Theria Bilateria Cell.Organisms CYP2A13 HGNC:2608 cytochrome P450, family 2, subfamily A, polypeptide 13 Q16696 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 8 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Cell.Organisms CYP2A6 HGNC:2610 cytochrome P450, family 2, subfamily A, polypeptide 6 P11509 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 2726448 mitochondrion 8 0 endoplasmic reticulum endoplasmic reticulum NA NA Cell.Organisms CYP2A7 HGNC:2611 cytochrome P450, family 2, subfamily A, polypeptide 7 P20853 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Microsome (GO:0005792) 11960914 mitochondrion 7 0 mitochondrion mitochondrion Euteleostomi Bilateria Cell.Organisms CYP2B6 HGNC:2615 cytochrome P450, family 2, subfamily B, polypeptide 6 P20813 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 11602525,11353758,11298076 mitochondrion 9 0 endoplasmic reticulum endoplasmic reticulum Theria Theria Cell.Organisms CYP2C18 HGNC:2620 cytochrome P450, family 2, subfamily C, polypeptide 18 P33260 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 11093772 endoplasmic reticulum membrane 8 0 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms CYP2C19 HGNC:2621 cytochrome P450, family 2, subfamily C, polypeptide 19 P33261 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 10233205 endoplasmic reticulum membrane 10 0 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms CYP2C8 HGNC:2622 cytochrome P450, family 2, subfamily C, polypeptide 8 P10632 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 12936704,12920163,10874126,12920163,12936704,10874126 mitochondrion membrane 8 0 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms CYP2C9 HGNC:2623 cytochrome P450, family 2, subfamily C, polypeptide 9 P11712 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 11397381 endoplasmic reticulum membrane 10 0 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms CYP2D6 HGNC:2625 cytochrome P450, family 2, subfamily D, polypeptide 6 P10635 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 10233205,15039299 endoplasmic reticulum membrane 6 2 endoplasmic reticulum endoplasmic reticulum Tetrapoda Bilateria NA CYP2E1 HGNC:2631 cytochrome P450, family 2, subfamily E, polypeptide 1 P05181 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 14661969,8809087 endoplasmic reticulum membrane 9 0 endoplasmic reticulum. golgi apparatus multiple Human Opisthokonta Cell.Organisms CYP2F1 HGNC:2632 cytochrome P450, family 2, subfamily F, polypeptide 1 P24903 Endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 10383923 endoplasmic reticulum membrane 8 0 endoplasmic reticulum endoplasmic reticulum Theria Tetrapoda Cell.Organisms CYP2J2 HGNC:2634 cytochrome P450, family 2, subfamily J, polypeptide 2 P51589 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 8631948 endoplasmic reticulum membrane 11 0 endoplasmic reticulum endoplasmic reticulum Chordata Eukaryota Cell.Organisms CYP2R1 HGNC:20580 cytochrome P450, family 2, subfamily R, polypeptide 1 Q6VVX0 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Microsome (GO:0005792) 15465040,12867411 endoplasmic reticulum membrane 9 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi NA CYP2S1 HGNC:15654 cytochrome P450, family 2, subfamily S, polypeptide 1 Q96SQ9 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 11181079 mitochondrion 8 0 endoplasmic reticulum endoplasmic reticulum Theria Theria Cell.Organisms CYP2U1 HGNC:20582 cytochrome P450, family 2, subfamily U, polypeptide 1 Q7Z449 Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane. Microsome (GO:0005792) 14975754 endoplasmic reticulum membrane 11 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms CYP2W1 HGNC:20243 cytochrome P450, family 2, subfamily W, polypeptide 1 Q8TAV3 Membrane; Peripheral membrane protein (Potential). Endoplasmic reticulum membrane (Potential). endoplasmic reticulum membrane 11 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Amniota Cell.Organisms CYP39A1 HGNC:17449 cytochrome P450, family 39, subfamily A, polypeptide 1 Q9NYL5 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 10748047 endoplasmic reticulum membrane 6 1 endoplasmic reticulum endoplasmic reticulum Tetrapoda Euteleostomi Cell.Organisms CYP3A4 HGNC:2637 cytochrome P450, family 3, subfamily A, polypeptide 4 P08684 Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10222036 endoplasmic reticulum membrane 22 3 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Eukaryota Cell.Organisms CYP3A43 HGNC:17450 cytochrome P450, family 3, subfamily A, polypeptide 43 Q9HB55 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 20 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms CYP3A5 HGNC:2638 cytochrome P450, family 3, subfamily A, polypeptide 5 P20815 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion (GO:0005739) endoplasmic reticulum membrane 20 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms CYP3A7 HGNC:2640 cytochrome P450, family 3, subfamily A, polypeptide 7 P24462 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 11093772 endoplasmic reticulum membrane 21 3 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms CYP46A1 HGNC:2641 cytochrome P450, family 46, subfamily A, polypeptide 1 Q9Y6A2 Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10377398 endoplasmic reticulum membrane 11 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Eukaryota Cell.Organisms CYP4A11 HGNC:2642 cytochrome P450, family 4, subfamily A, polypeptide 11 Q02928 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 8914854,10660572,9618440 endoplasmic reticulum membrane 8 2 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Cell.Organisms CYP4A22 HGNC:20575 cytochrome P450, family 4, subfamily A, polypeptide 22 Q5TCH4 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane; Peripheral membrane protein (By similarity). endoplasmic reticulum membrane 9 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Cell.Organisms CYP4B1 HGNC:2644 cytochrome P450, family 4, subfamily B, polypeptide 1 P13584 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 11062028 endoplasmic reticulum membrane 6 2 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Cell.Organisms CYP4F11 HGNC:13265 cytochrome P450, family 4, subfamily F, polypeptide 11 Q9HBI6 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) mitochondrion 9 2 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms CYP4F12 HGNC:18857 cytochrome P450, family 4, subfamily F, polypeptide 12 Q9HCS2 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 8 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms CYP4F2 HGNC:2645 cytochrome P450, family 4, subfamily F, polypeptide 2 P78329 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 10660572 endoplasmic reticulum membrane 9 2 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms CYP4F22 HGNC:26820 cytochrome P450, family 4, subfamily F, polypeptide 22 Q6NT55 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane; Peripheral membrane protein (By similarity). endoplasmic reticulum membrane 6 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms CYP4F3 HGNC:2646 cytochrome P450, family 4, subfamily F, polypeptide 3 Q08477 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 8486631 endoplasmic reticulum membrane 8 2 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms CYP4F8 HGNC:2648 cytochrome P450, family 4, subfamily F, polypeptide 8 P98187 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome membrane (By similarity). Endoplasmic reticulum (GO:0005783) 12464258,10791960 endoplasmic reticulum membrane 9 2 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms CYP4V2 HGNC:23198 cytochrome P450, family 4, subfamily V, polypeptide 2 Q6ZWL3 Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 8 2 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms CYP4X1 HGNC:20244 cytochrome P450, family 4, subfamily X, polypeptide 1 Q8N118 Endoplasmic reticulum membrane (By similarity); Single-pass membrane protein (Potential). Microsome membrane (By similarity). Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 8 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Cell.Organisms CYP4Z1 HGNC:20583 cytochrome P450, family 4, subfamily Z, polypeptide 1 Q86W10 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 15059886 endoplasmic reticulum membrane 8 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Theria Cell.Organisms CYP51A1 HGNC:2649 cytochrome P450, family 51, subfamily A, polypeptide 1 Q16850 Endoplasmic reticulum membrane (Potential). Microsome membrane (Potential). Endoplasmic reticulum (GO:0005783) 11678326 endoplasmic reticulum membrane 8 2 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms CYP7A1 HGNC:2651 cytochrome P450, family 7, subfamily A, polypeptide 1 P22680 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 7288293 endoplasmic reticulum membrane 18 2 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Cell.Organisms CYP7B1 HGNC:2652 cytochrome P450, family 7, subfamily B, polypeptide 1 O75881 Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 9802883 endoplasmic reticulum membrane 18 3 endoplasmic reticulum endoplasmic reticulum Chordata Opisthokonta Cell.Organisms CYP8B1 HGNC:2653 cytochrome P450, family 8, subfamily B, polypeptide 1 Q9UNU6 Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. endoplasmic reticulum membrane 28 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Cell.Organisms CYR61 HGNC:2654 cysteine-rich, angiogenic inducer, 61 O00622 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9600969,11287419,15561729,9488038 secreted 100 0 secreted secreted Chordata Chordata Bilateria CYS1 HGNC:18525 cystin 1 Q717R9 Cell projection, cilium membrane; Lipid- anchor. Cytoplasm, cytoskeleton, cilium axoneme. Note=Expression is enriched in the ciliary axoneme. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus. Axoneme (GO:0005930) 11854326 nucleus 57 0 cytoplasm cytoplasm Euarchontoglires Euarchontoglires Boreoeutheria CYSLTR1 HGNC:17451 cysteinyl leukotriene receptor 1 Q9Y271 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10391245 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa CYSLTR2 HGNC:18274 cysteinyl leukotriene receptor 2 Q9NS75 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10851239 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa CYSTM1 HGNC:30239 cysteine-rich transmembrane module containing 1 Q9H1C7 Membrane; Single-pass membrane protein (Potential). secreted 95 0 secreted secreted Catarrhini Catarrhini NA CYTH1 HGNC:9501 cytohesin 1 Q15438 Cell membrane. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Lysosome (GO:0005764); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10772823,9614087,9693361,10341214,12606567,10748148,10748148,10341214,8706128,12606567 cytoplasm 36 0 cytoplasm. golgi apparatus. lysosome. nucleus multiple Bilateria Eukaryota Cell.Organisms CYTH2 HGNC:9502 cytohesin 2 Q99418 Cell membrane. Cytoplasm. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Requires also interaction with phosphoinositides for targeting to plasma membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytosol (GO:0005829); Nucleus (GO:0005634); Lysosome (GO:0005764) 9417041,12920129,9550703,9417041,12920129,9550703,10806099,10806099,10531036,10806099,10806099,10748148 cytoplasm 36 0 cytoplasm. golgi apparatus. lysosome. nucleus multiple Bilateria Eukaryota Cell.Organisms CYTH3 HGNC:9504 cytohesin 3 O43739 Cell membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9742223,9742223 cytoplasm 36 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms CYTH4 HGNC:9505 cytohesin 4 Q9UIA0 Cell membrane. cytoplasm 19 0 cytoplasm cytoplasm Theria Amniota Cell.Organisms CYTIP HGNC:9506 cytohesin 1 interacting protein O60759 Cytoplasm. Early endosome. Note=Recruited from the cytosol to endosomes by SNX27. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12606567,12606567 cytoplasm 46 0 cytoplasm. endosome multiple Euteleostomi Euteleostomi Bilateria CYTL1 HGNC:24435 cytokine-like 1 Q9NRR1 Secreted. Extracellular (GO:0005576) 10857752 secreted 100 0 secreted secreted Amniota Euteleostomi Euteleostomi CYYR1 HGNC:16274 cysteine/tyrosine-rich 1 Q96J86 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 91 1 secreted secreted Euteleostomi Euteleostomi Euteleostomi D2HGDH HGNC:28358 D-2-hydroxyglutarate dehydrogenase Q8N465 Mitochondrion (Probable). mitochondrion 46 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms DAAM1 HGNC:18142 dishevelled associated activator of morphogenesis 1 Q9Y4D1 Cytoplasm. Note=Perinuclear. Nucleus (GO:0005634);Cytoplasm (GO:0005737) 17081983/ cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota DAAM2 HGNC:18143 dishevelled associated activator of morphogenesis 2 Q86T65 cytoplasm 59 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DAB1 HGNC:2661 Dab, reelin signal transducer, homolog 1 (Drosophila) O75553 Cytoplasm (GO:0005737) 12646221,9716537 cytoplasm 38 0 cytoplasm cytoplasm Euteleostomi Bilateria Holozoa DAB2 HGNC:2662 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) P98082 Cytoplasm. Cytoplasmic vesicle, clathrin- coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 10769163,11967127,9620555/17081983 cytoplasm 37 0 cytoplasm cytoplasm Chordata Bilateria Holozoa DAB2IP HGNC:17294 DAB2 interacting protein Q5VWQ8 Cytoplasm. Cell membrane; Peripheral membrane protein (Potential). Membrane. Cell projection, dendrite (By similarity). Note=Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum (By similarity). Colocalizes with TIRAP at the plasma membrane. Colocalizes with ARF6 at the plasma membrane and endocytic vesicles. Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha. Phosphatidylinositol 4- phosphate (PtdIns4P) binding is essential for plasma membrane localization. cytoplasm 12 1 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota DACH1 HGNC:2663 dachshund family transcription factor 1 Q9UI36 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14525983,11025202,11543628,15492887 nucleus 98 0 cytoplasm. nucleus multiple Human Euteleostomi Eumetazoa DACH2 HGNC:16814 dachshund family transcription factor 2 Q96NX9 Nucleus (Probable). nucleus 56 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa DACT1 HGNC:17748 dishevelled-binding antagonist of beta-catenin 1 Q9NYF0 Cytoplasm. Nucleus. Cell junction, synapse (By similarity). Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence. cytoplasm 41 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Craniata DACT2 HGNC:21231 dishevelled-binding antagonist of beta-catenin 2 Q5SW24 cytoplasm 18 0 cytoplasm cytoplasm Amniota Euteleostomi Euteleostomi DACT3 HGNC:30745 dishevelled-binding antagonist of beta-catenin 3 Q96B18 cytoplasm 20 0 cytoplasm cytoplasm Homininae Eutheria Euteleostomi DAD1 HGNC:2664 defender against cell death 1 P61803 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 9144178,9167970 endoplasmic reticulum membrane 34 3 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota DAG1 HGNC:2666 dystroglycan 1 (dystrophin-associated glycoprotein 1) Q14118 Alpha-dystroglycan: Secreted, extracellular space. Beta-dystroglycan: Cell membrane; Single- pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann- cell microvilli. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8798547,9153251,1741056,9153251,1741056 plasma membrane 22 1 cytoplasm. nucleus. plasma membrane. secreted multiple Deuterostomia Bilateria Metazoa DAGLA HGNC:1165 diacylglycerol lipase, alpha Q9Y4D2 Cell membrane; Multi-pass membrane protein. plasma membrane 100 5 plasma membrane plasma membrane Deuterostomia Eukaryota Eukaryota DAGLB HGNC:28923 diacylglycerol lipase, beta Q8NCG7 Cell membrane; Multi-pass membrane protein. plasma membrane 100 6 plasma membrane plasma membrane Human Eukaryota Eukaryota DAK HGNC:24552 dihydroxyacetone kinase 2 homolog (S. cerevisiae) Q3LXA3 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms DALRD3 HGNC:25536 DALR anticodon binding domain containing 3 Q5D0E6 mitochondrion 34 0 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms DAND5 HGNC:26780 DAN domain family member 5, BMP antagonist Q8N907 Secreted (Probable). Extracellular (GO:0005576) 15466485 secreted 21 0 secreted secreted Mammalia Mammalia Eumetazoa DAO HGNC:2671 D-amino-acid oxidase P14920 Peroxisome. Peroxisome (GO:0005777) 1356107,2901986,2885296 peroxisome 100 0 peroxisome peroxisome Opisthokonta Cell.Organisms Cell.Organisms DAOA HGNC:21191 D-amino acid oxidase activator P59103 Golgi apparatus. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12364586,12364586 golgi apparatus 100 0 endoplasmic reticulum. golgi apparatus multiple Homininae Homininae Euarchontoglires DAP HGNC:2672 death-associated protein P51397 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9916995,17081983,17081983 nucleus 31 0 cytoplasm. nucleus multiple Human Bilateria Metazoa DAP3 HGNC:2673 death associated protein 3 P51398 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12359235,11248257,15598749,12099703,12099703 mitochondrion 100 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Eukaryota DAPK1 HGNC:2674 death-associated protein kinase 1 P53355 Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Isoform 2: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12730201,12730201 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms DAPK2 HGNC:2675 death-associated protein kinase 2 Q9UIK4 Cytoplasm. Cytoplasmic vesicle, autophagosome lumen. Cytoplasm (GO:0005737); Lysosome (GO:0005764); Nucleus (GO:0005634) 11980920,10376525,11980920,17081983 cytoplasm 100 0 cytoplasm. lysosome. nucleus multiple Catarrhini Euteleostomi Cell.Organisms DAPK3 HGNC:2676 death-associated protein kinase 3 O43293 Nucleus. Cytoplasm. Nucleus, PML body. Chromosome, centromere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Isoform 2: Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9488481,12917339,10602480,10580117,10602480 cytoplasm 73 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms DAPL1 HGNC:21490 death associated protein-like 1 A0PJW8 nucleus 26 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria DAPP1 HGNC:16500 dual adaptor of phosphotyrosine and 3-phosphoinositides Q9UN19 Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12101241,12101241 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota DARC HGNC:4035 Duffy blood group, atypical chemokine receptor Q16570 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8542025 plasma membrane 10 7 plasma membrane plasma membrane Theria Theria Amniota DARS HGNC:2678 aspartyl-tRNA synthetase P14868 Cytoplasm. Cytoplasm (GO:0005737); Cytosol (GO:0005829) 10200289,15561729 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DARS2 HGNC:25538 aspartyl-tRNA synthetase 2, mitochondrial Q6PI48 Mitochondrion matrix. Mitochondrion (GO:0005739) 15779907 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms DAW1 HGNC:26383 dynein assembly factor with WDR repeat domains 1 Q8N136 Cell projection, cilium (Probable). cytoplasm 53 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms DAXX HGNC:2681 death-domain associated protein Q9UER7 Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome, centromere. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,11495919,15016915,16569639,15983381,16810318,15878163,16845383,16331268,18566590,,11495919 endoplasmic reticulum membrane 27 0 cytoplasm. nucleus multiple Theria Bilateria NA DAZ1 HGNC:2682 deleted in azoospermia 1 Q9NQZ3 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Microtubule (GO:0005874) 11058556,11058556,16946704,16946704,16946704 cytoplasm 67 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms DAZ2 HGNC:15964 deleted in azoospermia 2 Q13117 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9557839,11058556 cytoplasm 67 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms DAZ3 HGNC:15965 deleted in azoospermia 3 Q9NR90 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10936047,15066460,11058556,15066460,11058556 cytoplasm 67 0 cytoplasm. nucleus multiple NA NA Cell.Organisms DAZ4 HGNC:15966 deleted in azoospermia 4 Q86SG3 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11058556,11058556 cytoplasm 67 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms DAZAP1 HGNC:2683 DAZ associated protein 1 Q96EP5 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12185095,10857750,11604102,12185095 cytoplasm 80 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms DAZAP2 HGNC:2684 DAZ associated protein 2 Q15038 Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm. nucleus 73 0 cytoplasm. nucleus multiple Eutheria Bilateria Olfactores DAZL HGNC:2685 deleted in azoospermia-like Q92904 Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10527983,11058556,10340994,11058556 cytoplasm 86 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms DBF4 HGNC:17364 DBF4 zinc finger Q9UBU7 Nucleus. Nucleus (GO:0005634) 10373557,10523313 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Opisthokonta DBF4B HGNC:17883 DBF4 zinc finger B Q8NFT6 Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction. Nucleus (GO:0005634) 12065429,15668232 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Eukaryota DBH HGNC:2689 dopamine beta-hydroxylase (dopamine beta-monooxygenase) P09172 Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential). Extracellular (GO:0005576); Cytoplasmic vesicle (GO:0016023); Integral to membrane (GO:0016021) 7759508,7759508,7759508 endoplasmic reticulum membrane 19 1 secreted secreted Chordata Bilateria Eukaryota DBI HGNC:2690 diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) P07108 Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9657356,9477145,8245508,8043504,8396705 cytoplasm 44 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. secreted multiple Eukaryota Cell.Organisms Cell.Organisms DBN1 HGNC:2695 drebrin 1 Q16643 Cytoplasm. Cytoplasm (GO:0005737) 11578820 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota DBNDD1 HGNC:28455 dysbindin (dystrobrevin binding protein 1) domain containing 1 Q9H9R9 nucleus 48 0 nucleus nucleus Tetrapoda Euteleostomi Craniata DBNDD2 HGNC:15881 dysbindin (dystrobrevin binding protein 1) domain containing 2 Q9BQY9 mitochondrion 28 0 mitochondrion mitochondrion NA NA Euteleostomi DBNL HGNC:2696 drebrin-like Q9UJU6 Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasm, cytosol (By similarity). Cell junction, synapse (By similarity). Cell projection (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, clathrin- coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, podosome (By similarity). Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). Actin cytoskeleton (GO:0015629); Dendrite (GO:0030425); Cytoplasm (GO:0005737) 9891087,11595038,12565838 cytoplasm 32 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota DBP HGNC:2697 D site of albumin promoter (albumin D-box) binding protein Q10586 Nucleus. Nucleus (GO:0005634) 10650888 nucleus 100 0 nucleus nucleus Eutheria Tetrapoda Holozoa DBR1 HGNC:15594 debranching RNA lariats 1 Q9UK59 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11886864,17081983,17081983 nucleus 70 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DBT HGNC:2698 dihydrolipoamide branched chain transacylase E2 P11182 Mitochondrion matrix. Mitochondrion (GO:0005739) 1943690 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms DBX1 HGNC:33185 developing brain homeobox 1 A6NMT0 Nucleus (By similarity). nucleus 87 0 nucleus nucleus Theria Deuterostomia Eukaryota DBX2 HGNC:33186 developing brain homeobox 2 Q6ZNG2 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 31 0 nucleus nucleus Theria Bilateria Eukaryota DCAF10 HGNC:23686 DDB1 and CUL4 associated factor 10 Q5QP82 secreted 27 0 secreted secreted Deuterostomia Bilateria Cell.Organisms DCAF11 HGNC:20258 DDB1 and CUL4 associated factor 11 Q8TEB1 nucleus 10 0 nucleus nucleus Theria Eukaryota Cell.Organisms DCAF12 HGNC:19911 DDB1 and CUL4 associated factor 12 Q5T6F0 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DCAF12L1 HGNC:29395 DDB1 and CUL4 associated factor 12-like 1 Q5VU92 cytoplasm 56 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms DCAF12L2 HGNC:32950 DDB1 and CUL4 associated factor 12-like 2 Q5VW00 cytoplasm 59 0 cytoplasm cytoplasm Eutheria Eutheria Eukaryota DCAF13 HGNC:24535 DDB1 and CUL4 associated factor 13 Q9NV06 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730) 11790298 nucleus 35 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DCAF15 HGNC:25095 DDB1 and CUL4 associated factor 15 Q66K64 nucleus 44 0 nucleus nucleus Chordata Chordata Metazoa DCAF16 HGNC:25987 DDB1 and CUL4 associated factor 16 Q9NXF7 secreted 24 0 secreted secreted Catarrhini Eutheria Eutheria DCAF17 HGNC:25784 DDB1 and CUL4 associated factor 17 Q5H9S7 Membrane; Multi-pass membrane protein (Potential). Nucleus, nucleolus. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions. cytoplasm 36 2 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta DCAF4 HGNC:20229 DDB1 and CUL4 associated factor 4 Q8WV16 cytoplasm 20 1 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DCAF4L1 HGNC:27723 DDB1 and CUL4 associated factor 4-like 1 Q3SXM0 cytoplasm 16 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DCAF4L2 HGNC:26657 DDB1 and CUL4 associated factor 4-like 2 Q8NA75 cytoplasm 24 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DCAF5 HGNC:20224 DDB1 and CUL4 associated factor 5 Q96JK2 nucleus 8 0 nucleus nucleus Bilateria Bilateria Cell.Organisms DCAF6 HGNC:30002 DDB1 and CUL4 associated factor 6 Q58WW2 Nucleus. Nucleus (GO:0005634) 15784617 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Cell.Organisms DCAF7 HGNC:30915 DDB1 and CUL4 associated factor 7 P61962 Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm. Cytoplasm (GO:0005737) cytoplasm 45 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DCAF8 HGNC:24891 DDB1 and CUL4 associated factor 8 Q5TAQ9 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 20 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms DCAF8L1 HGNC:31810 DDB1 and CUL4 associated factor 8-like 1 A6NGE4 nucleus 14 0 nucleus nucleus NA NA Cell.Organisms DCAF8L2 HGNC:31811 DDB1 and CUL4 associated factor 8-like 2 P0C7V8 nucleus 17 0 nucleus nucleus Theria Eukaryota Cell.Organisms DCAKD HGNC:26238 dephospho-CoA kinase domain containing Q8WVC6 cytoplasm 33 1 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DCBLD1 HGNC:21479 discoidin, CUB and LCCL domain containing 1 Q8N8Z6 Membrane; Single-pass type I membrane protein (Potential). secreted 23 1 secreted secreted Euteleostomi Bilateria Eukaryota DCBLD2 HGNC:24627 discoidin, CUB and LCCL domain containing 2 Q96PD2 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11447234,11973641 secreted 34 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms DCC HGNC:2701 deleted in colorectal carcinoma P43146 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Axon (GO:0030424) 7926722,15494733 plasma membrane 42 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms DCD HGNC:14669 dermcidin P81605 Secreted. Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 11694882,16188874,11694882 secreted 100 0 golgi apparatus. secreted multiple Catarrhini Euarchontoglires Primates DCDC1 HGNC:20625 doublecortin domain containing 1 P59894 Cytoskeleton (GO:0005856) 12820024 nucleus 61 0 nucleus nucleus NA NA Holozoa DCDC2 HGNC:18141 doublecortin domain containing 2 Q9UHG0 cytoplasm 15 0 cytoplasm cytoplasm Chordata Chordata Eukaryota DCDC2B HGNC:32576 doublecortin domain containing 2B A2VCK2 cytoplasm 12 0 cytoplasm cytoplasm NA NA Opisthokonta DCDC2C HGNC:32696 doublecortin domain containing 2C A8MYV0 cytoplasm 10 0 cytoplasm cytoplasm Eutheria Eutheria Holozoa DCDC5 HGNC:24799 doublecortin domain containing 5 Q6ZRR9 Nucleus (GO:0005634) 16869982 nucleus 63 0 nucleus nucleus Mammalia Deuterostomia NA DCHS1 HGNC:13681 dachsous cadherin-related 1 Q96JQ0 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 17 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms DCHS2 HGNC:23111 dachsous cadherin-related 2 Q6V1P9 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 15003449 plasma membrane 15 0 n/a n/a Bilateria Cell.Organisms Cell.Organisms DCK HGNC:2704 deoxycytidine kinase P27707 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9804782,9342341,9804782 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms DCLK1 HGNC:2700 doublecortin-like kinase 1 O15075 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) ,11124993 cytoplasm 64 0 cytoplasm cytoplasm Bilateria Opisthokonta Cell.Organisms DCLK2 HGNC:19002 doublecortin-like kinase 2 Q8N568 Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Bilateria Opisthokonta Cell.Organisms DCLK3 HGNC:19005 doublecortin-like kinase 3 Q9C098 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 31 1 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms DCLRE1A HGNC:17660 DNA cross-link repair 1A Q6PJP8 Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1. Nucleus (GO:0005634) 12446782 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms DCLRE1B HGNC:17641 DNA cross-link repair 1B Q9H816 Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome. Nucleus (GO:0005634) 15467758 nucleus 26 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms DCLRE1C HGNC:17642 DNA cross-link repair 1C Q96SD1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12055248,12055248 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms DCN HGNC:2705 decorin P07585 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 12106908 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms DCP1A HGNC:18714 decapping mRNA 1A Q9NPI6 Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11836524,16364915 cytoplasm 23 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta NA DCP1B HGNC:24451 decapping mRNA 1B Q8IZD4 Cytoplasm. Nucleus (By similarity). Cytoplasm (GO:0005737) 15067023,16364915 cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota DCP2 HGNC:24452 decapping mRNA 2 Q8IU60 Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12486012,15067023,12515382,12417715,12218187,15273322,14527413,12923261,12768200,16364915,15273322,14527413,17081983 cytoplasm 35 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota DCPS HGNC:29812 decapping enzyme, scavenger Q96C86 Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12871939,12871939,12198172 cytoplasm 27 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota DCST1 HGNC:26539 DC-STAMP domain containing 1 Q5T197 Membrane; Multi-pass membrane protein (Potential). plasma membrane 30 8 plasma membrane plasma membrane Euteleostomi Bilateria Bilateria DCST2 HGNC:26562 DC-STAMP domain containing 2 Q5T1A1 Membrane; Multi-pass membrane protein (Potential). plasma membrane 77 9 plasma membrane plasma membrane Theria Bilateria Bilateria DCSTAMP HGNC:18549 dendrocyte expressed seven transmembrane protein Q9H295 Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein (By similarity). Endosome (By similarity). Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). Plasma membrane (GO:0005886) 11345586,11169400 endoplasmic reticulum membrane 36 6 endoplasmic reticulum membrane. plasma membrane multiple Tetrapoda Euteleostomi Bilateria DCT HGNC:2709 dopachrome tautomerase P40126 Melanosome membrane; Single-pass type I membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8267597,1537334 secreted 14 1 cytoplasm. melanosome membrane. plasma membrane multiple Chordata Opisthokonta Cell.Organisms DCTD HGNC:2710 dCMP deaminase P32321 cytoplasm 16 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms DCTN1 HGNC:2711 dynactin 1 Q14203 Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Endoplasmic reticulum (GO:0005783) 8856662,9722614,1828535,11153697,12391026,9722614,15580264 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Bilateria Eukaryota Eukaryota DCTN2 HGNC:2712 dynactin 2 (p50) Q13561 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Zymogen granule (GO:0042588) 8647893,16278343 cytoplasm 46 0 cytoplasm cytoplasm Eutheria Eukaryota Eukaryota DCTN3 HGNC:2713 dynactin 3 (p22) O75935 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9722614,9722614,9722614 nucleus 43 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota DCTN4 HGNC:15518 dynactin 4 (p62) Q9UJW0 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Nucleus (GO:0005634); Microtubule (GO:0005874) 10671518,10671518,10671518,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota DCTN5 HGNC:24594 dynactin 5 (p25) Q9BTE1 Cytoplasm, cytoskeleton (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms DCTN6 HGNC:16964 dynactin 6 O00399 Cytoplasm, cytoskeleton (By similarity). Mitochondrion (GO:0005739) 10318868 cytoplasm 34 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms DCTPP1 HGNC:28777 dCTP pyrophosphatase 1 Q9H773 Cytoplasm (By similarity). cytoplasm 70 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms DCUN1D1 HGNC:18184 DCN1, defective in cullin neddylation 1, domain containing 1 Q96GG9 nucleus 25 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DCUN1D2 HGNC:20328 DCN1, defective in cullin neddylation 1, domain containing 2 Q6PH85 nucleus 26 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DCUN1D3 HGNC:28734 DCN1, defective in cullin neddylation 1, domain containing 3 Q8IWE4 nucleus 22 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota DCUN1D4 HGNC:28998 DCN1, defective in cullin neddylation 1, domain containing 4 Q92564 nucleus 24 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota DCUN1D5 HGNC:28409 DCN1, defective in cullin neddylation 1, domain containing 5 Q9BTE7 nucleus 20 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota DCX HGNC:2714 doublecortin O43602 Cytoplasm. Cell projection (By similarity). Note=Localizes at neurite tips (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12427674,17081983 cytoplasm 67 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota DCXR HGNC:18985 dicarbonyl/L-xylulose reductase Q7Z4W1 Membrane; Peripheral membrane protein (By similarity). Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). Integral to membrane (GO:0016021); Mitochondrion (GO:0005739) 11882650,15598749 cytoplasm 65 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms DDA1 HGNC:28360 DET1 and DDB1 associated 1 Q9BW61 nucleus 71 0 nucleus nucleus Tetrapoda Eukaryota Eumetazoa DDAH1 HGNC:2715 dimethylarginine dimethylaminohydrolase 1 O94760 Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 10691782,10691782 cytoplasm 48 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms DDAH2 HGNC:2716 dimethylarginine dimethylaminohydrolase 2 O95865 Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes. Cytoplasm (GO:0005737) 10691782 cytoplasm 53 0 cytoplasm. mitochondrion multiple Theria Euteleostomi NA DDB1 HGNC:2717 damage-specific DNA binding protein 1, 127kDa Q16531 Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829) ,10777491,19059367,18593899,,10777491,15635413,,18593899, nucleus 11 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota DDB2 HGNC:2718 damage-specific DNA binding protein 2, 48kDa Q92466 Nucleus. Note=Accumulates at sites of DNA damage following UV irradiation. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytosol (GO:0005829) 17081983,17081983/,8350924,18593899,,,18593899, nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms DDC HGNC:2719 dopa decarboxylase (aromatic L-amino acid decarboxylase) P20711 Cytoplasm (GO:0005737) 12200739 cytoplasm 76 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DDHD1 HGNC:19714 DDHD domain containing 1 Q8NEL9 Cytoplasm. cytoplasm 100 1 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota DDHD2 HGNC:29106 DDHD domain containing 2 O94830 Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P. Cytoplasm (GO:0005737); Microsome (GO:0005792) 11788596,11788596 cytoplasm 21 1 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota DDI1 HGNC:18961 DNA-damage inducible 1 homolog 1 (S. cerevisiae) Q8WTU0 cytoplasm 64 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DDI2 HGNC:24578 DNA-damage inducible 1 homolog 2 (S. cerevisiae) Q5TDH0 Cytoplasm (GO:0005737) 17081983 cytoplasm 77 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DDIT3 HGNC:2726 DNA-damage-inducible transcript 3 P35638 Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. Nucleus (GO:0005634) 1547942 nucleus 16 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Euteleostomi DDIT4 HGNC:24944 DNA-damage-inducible transcript 4 Q9NX09 Mitochondrion (By similarity). Cytoplasm, cytosol. nucleus 62 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Bilateria DDIT4L HGNC:30555 DNA-damage-inducible transcript 4-like Q96D03 Cytoplasm (By similarity). nucleus 50 0 nucleus nucleus Chordata Bilateria Bilateria DDN HGNC:24458 dendrin O94850 Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Perikaryon (By similarity). Nucleus (By similarity). Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites (By similarity). Cytoplasm (GO:0005737) 8915891 nucleus 65 0 cytoplasm cytoplasm Eutheria Eutheria Amniota DDO HGNC:2727 D-aspartate oxidase Q99489 Peroxisome. Peroxisome (GO:0005777) 1991137 peroxisome 100 0 peroxisome peroxisome Opisthokonta Cell.Organisms Cell.Organisms DDOST HGNC:2728 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) P39656 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 7625827,9367678,15561729,15598749 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple NA NA Eukaryota DDR1 HGNC:2730 discoidin domain receptor tyrosine kinase 1 Q08345 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted (Potential). Isoform 4: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9659899 plasma membrane 93 1 plasma membrane plasma membrane Deuterostomia Bilateria NA DDR2 HGNC:2731 discoidin domain receptor tyrosine kinase 2 Q16832 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11133186,9659899 plasma membrane 100 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms DDRGK1 HGNC:16110 DDRGK domain containing 1 Q96HY6 Endoplasmic reticulum. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Eukaryota DDT HGNC:2732 D-dopachrome tautomerase P30046 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 8267597 cytoplasm 68 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms DDTL HGNC:33446 D-dopachrome tautomerase-like A6NHG4 Cytoplasm (By similarity). cytoplasm 63 0 cytoplasm cytoplasm Human Catarrhini Cell.Organisms DDX1 HGNC:2734 DEAD (Asp-Glu-Ala-Asp) box helicase 1 Q92499 Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR- induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM- dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for proper localization of HIV-1 Rev. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8135819,19058135,15635413,11790298 nucleus 17 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DDX10 HGNC:2735 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 Q13206 Nucleus (GO:0005634); Nucleolus (GO:0005730) 9166830,17081983,15635413,11790298 nucleus 34 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX11 HGNC:2736 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 Q96FC9 Nucleus. Nucleus, nucleolus. Note=During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co- localizes with bovine papillomavirus type 1 regulatory protein E2 at early stages of mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8833153,9013641 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms DDX17 HGNC:2740 DEAD (Asp-Glu-Ala-Asp) box helicase 17 Q92841 Nucleus. Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8871553,19059367,15635413 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DDX18 HGNC:2741 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 Q9NVP1 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8861962,19059367,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX19A HGNC:25628 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A Q9NUU7 Cytoplasm (By similarity). Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Nuclear pore complex cytoplasmic fibrils. nucleus 23 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms DDX19B HGNC:2742 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B Q9UMR2 Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1424986/10428971,10428971 cytoplasm 24 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms DDX20 HGNC:2743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 Q9UHI6 Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10601333,17081983,10601333 cytoplasm 22 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DDX21 HGNC:2744 DEAD (Asp-Glu-Ala-Asp) box helicase 21 Q9NR30 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 8614622,15635413,11790298,19059367 nucleus 100 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms DDX23 HGNC:17347 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 Q9BUQ8 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) none,17081983,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms DDX24 HGNC:13266 DEAD (Asp-Glu-Ala-Asp) box helicase 24 Q9GZR7 Nucleus (GO:0005634); Nucleolus (GO:0005730) 10936056,17081983,15635413 nucleus 15 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX25 HGNC:18698 DEAD (Asp-Glu-Ala-Asp) box helicase 25 Q9UHL0 Cytoplasm. Nucleus (By similarity). Note=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity). Cytoplasm (GO:0005737) 10608860 cytoplasm 27 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms DDX26B HGNC:27334 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B Q5JSJ4 nucleus 63 0 nucleus nucleus Chordata Eukaryota NA DDX27 HGNC:15837 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 Q96GQ7 Nucleus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) none,15561729,15635413,11790298 nucleus 29 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DDX28 HGNC:17330 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 Q9NUL7 Nucleus. Mitochondrion. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11350955,15561729,11350955 nucleus 19 0 mitochondrion. nucleus multiple Deuterostomia Eukaryota Cell.Organisms DDX31 HGNC:16715 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 Q9H8H2 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX39A HGNC:17821 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A O00148 Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1. Nucleus (GO:0005634); Nucleolus (GO:0005730) 7601445,15635413,11790298 nucleus 80 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DDX39B HGNC:13917 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B Q13838 Nucleus. Nucleus speckle. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1. Nucleus (GO:0005634); Nucleolus (GO:0005730) 7601445,15635413,11790298 nucleus 82 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA DDX3X HGNC:2745 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked O00571 Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus during G(0) phase and in the cytoplasm during G1/S phase. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10329544,19059367,10329544,11790298 cytoplasm 53 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms DDX3Y HGNC:2699 DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked O15523 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11591417,11591417 cytoplasm 54 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms DDX4 HGNC:18700 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 Q9NQI0 Cytoplasm. Cytoplasm, perinuclear region (By similarity). Cytoplasm (GO:0005737) 10920202 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms DDX41 HGNC:18674 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 Q9UJV9 Nucleus (Potential). Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,17081983,17081983 cytoplasm 27 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DDX42 HGNC:18676 DEAD (Asp-Glu-Ala-Asp) box helicase 42 Q86XP3 Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12234937,17081983,17081983 nucleus 27 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Cell.Organisms DDX43 HGNC:18677 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 Q9NXZ2 nucleus 53 0 nucleus nucleus Bilateria Bilateria Cell.Organisms DDX46 HGNC:18681 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 Q7L014 Nucleus speckle. Nucleus, Cajal body. Note=Present in Cajal bodies (CBs) and nuclear speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms DDX47 HGNC:18682 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 Q9H0S4 Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11024137,11024137,15635413 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms DDX49 HGNC:18684 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 Q9Y6V7 Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298 nucleus 37 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DDX5 HGNC:2746 DEAD (Asp-Glu-Ala-Asp) box helicase 5 P17844 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 2762324,15561729,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms NA DDX50 HGNC:17906 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 Q9BQ39 Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 15034300,17081983,15635413,11790298,11891046,15034300,17081983,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms DDX51 HGNC:20082 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 Q8N8A6 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634) 11790298,15561729 nucleus 18 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX52 HGNC:20038 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 Q9Y2R4 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,11790298,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX53 HGNC:20083 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 Q86TM3 Nucleus. Nucleus (GO:0005634) 11922625 nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms DDX54 HGNC:20084 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 Q8TDD1 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12466272,15635413,11790298,12466272,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms DDX55 HGNC:20085 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 Q8NHQ9 Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 27 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DDX56 HGNC:18193 DEAD (Asp-Glu-Ala-Asp) box helicase 56 Q9NY93 Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 10749921,10749921,10749921,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DDX58 HGNC:19102 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 O95786 Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Note=Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles. Cytoplasm (GO:0005737) 15219805 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Cell.Organisms DDX59 HGNC:25360 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 Q5T1V6 Nucleus (GO:0005634) cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DDX6 HGNC:2747 DEAD (Asp-Glu-Ala-Asp) box helicase 6 P26196 Cytoplasm, P-body. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7614484,16364915,11839790 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA DDX60 HGNC:25942 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 Q8IY21 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms DDX60L HGNC:26429 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like Q5H9U9 cytoplasm 59 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms DEAF1 HGNC:14677 DEAF1 transcription factor O75398 Isoform 1: Nucleus. Cytoplasm. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9773984,9417089 nucleus 42 0 cytoplasm. nucleus. secreted multiple Eutheria Bilateria Eukaryota DEC1 HGNC:23658 deleted in esophageal cancer 1 Q9P2X7 Cytoplasm (GO:0005737) 10612805 secreted 69 1 cytoplasm cytoplasm Catarrhini Catarrhini Boreoeutheria DECR1 HGNC:2753 2,4-dienoyl CoA reductase 1, mitochondrial Q16698 Mitochondrion. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Peroxisome (GO:0005777) 9403065,10497069,15598749,8993540,7263650 mitochondrion 100 0 endoplasmic reticulum. mitochondrion. peroxisome multiple Euteleostomi Cell.Organisms Cell.Organisms DECR2 HGNC:2754 2,4-dienoyl CoA reductase 2, peroxisomal Q9NUI1 Peroxisome (By similarity). Peroxisome (GO:0005777) 11514237 peroxisome 79 0 peroxisome peroxisome NA NA Cell.Organisms DEDD HGNC:2755 death effector domain containing O75618 Cytoplasm. Nucleus, nucleolus (By similarity). Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11753564,11965497,11753564,11753564,9774341 nucleus 32 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa DEDD2 HGNC:24450 death effector domain containing 2 Q8WXF8 Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasmic vesicle (GO:0016023) 11965497,12527898,11741985,12235123,11965497,12527898,11741985,12235123,12235123 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria DEF6 HGNC:2760 differentially expressed in FDCP 6 homolog (mouse) Q9H4E7 Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12651066,15023524,15023524 cytoplasm 18 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota DEF8 HGNC:25969 differentially expressed in FDCP 8 homolog (mouse) Q6ZN54 nucleus 80 0 nucleus nucleus Bilateria Eukaryota Eukaryota DEFA1 HGNC:2761 defensin, alpha 1 P59665 Secreted. Cytoplasm (GO:0005737) 2997278 secreted 100 0 cytoplasm. secreted multiple Catarrhini Catarrhini Eutheria DEFA1B HGNC:33596 defensin, alpha 1B P59665 Secreted. secreted 100 0 secreted secreted NA NA Eutheria DEFA3 HGNC:2762 defensin, alpha 3, neutrophil-specific P59666 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted NA NA Eutheria DEFA4 HGNC:2763 defensin, alpha 4, corticostatin P12838 Secreted. Secretory granule (GO:0030141) 2500436 secreted 100 0 secreted secreted Human Human Eutheria DEFA5 HGNC:2764 defensin, alpha 5, Paneth cell-specific Q01523 Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form. Secretory granule (GO:0030141) 9169779 secreted 67 0 secreted secreted Euarchontoglires Euarchontoglires Eutheria DEFA6 HGNC:2765 defensin, alpha 6, Paneth cell-specific Q01524 Secreted. Secretory granule (GO:0030141) 8417977,8626737 secreted 100 0 secreted secreted Human Catarrhini Eutheria DEFB1 HGNC:2766 defensin, beta 1 P60022 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10223729,11453504,12728165 secreted 100 0 cytoplasm. secreted multiple Eutheria Eutheria Eutheria DEFB103A HGNC:15967 defensin, beta 103A P81534 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Eutheria Eutheria DEFB103B HGNC:31702 defensin, beta 103B P81534 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Eutheria Eutheria DEFB104A HGNC:18115 defensin, beta 104A Q8WTQ1 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Catarrhini Catarrhini Mammalia DEFB104B HGNC:26165 defensin, beta 104B Q8WTQ1 Secreted. secreted 100 0 secreted secreted Catarrhini Catarrhini Mammalia DEFB105A HGNC:18087 defensin, beta 105A Q8NG35 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Euarchontoglires Eutheria Boreoeutheria DEFB105B HGNC:29930 defensin, beta 105B Q8NG35 Secreted. secreted 100 0 secreted secreted Euarchontoglires Eutheria Boreoeutheria DEFB106A HGNC:18088 defensin, beta 106A Q8N104 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Theria Theria Mammalia DEFB106B HGNC:28879 defensin, beta 106B Q8N104 Secreted. secreted 100 0 secreted secreted Theria Theria Mammalia DEFB107A HGNC:18086 defensin, beta 107A Q8IZN7 Secreted. secreted 100 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB107B HGNC:31918 defensin, beta 107B Q8IZN7 Secreted. secreted 100 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB108B HGNC:29966 defensin, beta 108B Q8NET1 Secreted. secreted 100 0 secreted secreted Catarrhini Eutheria Mammalia DEFB110 HGNC:18091 defensin, beta 110 locus Q30KQ9 Secreted (By similarity). secreted 78 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB112 HGNC:18093 defensin, beta 112 Q30KQ8 Secreted (By similarity). Extracellular (GO:0005576) secreted 20 0 secreted secreted Homininae Eutheria Eutheria DEFB113 HGNC:18094 defensin, beta 113 Q30KQ7 Secreted (By similarity). secreted 84 0 secreted secreted Euarchontoglires Eutheria Boreoeutheria DEFB114 HGNC:18095 defensin, beta 114 Q30KQ6 Secreted (By similarity). Extracellular (GO:0005576) secreted 73 0 secreted secreted Catarrhini Eutheria Eutheria DEFB115 HGNC:18096 defensin, beta 115 Q30KQ5 Secreted (By similarity). secreted 29 0 secreted secreted Homininae Euarchontoglires Euarchontoglires DEFB116 HGNC:18097 defensin, beta 116 Q30KQ4 Secreted (By similarity). secreted 26 0 secreted secreted Euarchontoglires Eutheria Boreoeutheria DEFB118 HGNC:16196 defensin, beta 118 Q96PH6 Secreted. Nucleus (GO:0005634); Extracellular (GO:0005576) 11564719,11564719 secreted 100 0 nucleus. secreted multiple Euarchontoglires Eutheria Eutheria DEFB119 HGNC:18099 defensin, beta 119 Q8N690 Secreted (Potential). secreted 14 0 secreted secreted Eutheria Eutheria Boreoeutheria DEFB121 HGNC:18101 defensin, beta 121 Q5J5C9 Secreted (Potential). secreted 36 0 secreted secreted Catarrhini Eutheria Eutheria DEFB123 HGNC:18103 defensin, beta 123 Q8N688 Secreted (Potential). Extracellular (GO:0005576) secreted 33 0 secreted secreted Eutheria Eutheria Eutheria DEFB124 HGNC:18104 defensin, beta 124 Q8NES8 Secreted (Potential). Extracellular (GO:0005576) secreted 97 0 secreted secreted Eutheria Eutheria Eutheria DEFB125 HGNC:18105 defensin, beta 125 Q8N687 Secreted (Potential). Extracellular (GO:0005576) secreted 27 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB126 HGNC:15900 defensin, beta 126 Q9BYW3 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10491631,10491631 secreted 100 0 cytoplasm. secreted multiple Euarchontoglires Eutheria Eutheria DEFB127 HGNC:16206 defensin, beta 127 Q9H1M4 Secreted (Potential). Extracellular (GO:0005576) secreted 38 0 secreted secreted Catarrhini Eutheria Eutheria DEFB128 HGNC:18106 defensin, beta 128 Q7Z7B8 Secreted (Potential). secreted 21 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB129 HGNC:16218 defensin, beta 129 Q9H1M3 Secreted (Potential). Extracellular (GO:0005576) nucleus 30 0 nucleus nucleus Euarchontoglires Eutheria Eutheria DEFB130 HGNC:18107 defensin, beta 130 Q30KQ2 Secreted (Potential). secreted 92 0 secreted secreted NA NA Eutheria DEFB131 HGNC:18108 defensin, beta 131 P59861 Secreted (Potential). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12600824,12600824 secreted 77 0 cytoplasm. secreted multiple Euarchontoglires Eutheria Boreoeutheria DEFB132 HGNC:33806 defensin, beta 132 Q7Z7B7 Secreted (Potential). secreted 36 0 secreted secreted Catarrhini Eutheria Eutheria DEFB133 HGNC:31331 defensin, beta 133 Q30KQ1 Secreted (Potential). secreted 84 0 secreted secreted Euarchontoglires Euarchontoglires Euarchontoglires DEFB134 HGNC:32399 defensin, beta 134 Q4QY38 Secreted (Potential). secreted 66 0 secreted secreted Catarrhini Eutheria Eutheria DEFB135 HGNC:32400 defensin, beta 135 Q30KP9 Secreted (Potential). secreted 97 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB136 HGNC:34433 defensin, beta 136 Q30KP8 Secreted (Potential). secreted 97 0 secreted secreted Euarchontoglires Eutheria Eutheria DEFB4A HGNC:2767 defensin, beta 4A O15263 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12395153,11453504,12395153 secreted 100 0 cytoplasm. secreted multiple Euarchontoglires Euarchontoglires Boreoeutheria DEFB4B HGNC:30193 defensin, beta 4B O15263 Secreted. secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Boreoeutheria DEGS1 HGNC:13709 delta(4)-desaturase, sphingolipid 1 O15121 Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane (GO:0005789) 9188692 endoplasmic reticulum membrane 85 6 endoplasmic reticulum membrane. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms DEGS2 HGNC:20113 delta(4)-desaturase, sphingolipid 2 Q6QHC5 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 82 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Cell.Organisms DEK HGNC:2768 DEK oncogene P35659 Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12140263,11333257,9050861,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota DENND1A HGNC:29324 DENN/MADD domain containing 1A Q8TEH3 Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane. Cytoplasm (GO:0005737) 17081983 cytoplasm 28 1 cytoplasm cytoplasm Chordata Bilateria Eukaryota DENND1B HGNC:28404 DENN/MADD domain containing 1B Q6P3S1 Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). cytoplasm 14 3 cytoplasm cytoplasm NA NA Eukaryota DENND1C HGNC:26225 DENN/MADD domain containing 1C Q8IV53 Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). cytoplasm 15 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota DENND2A HGNC:22212 DENN/MADD domain containing 2A Q9ULE3 Cytoplasm, cytoskeleton. Note=Associated with actin filaments. cytoplasm 100 3 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota DENND2C HGNC:24748 DENN/MADD domain containing 2C Q68D51 cytoplasm 37 1 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota DENND2D HGNC:26192 DENN/MADD domain containing 2D Q9H6A0 Cytoplasm. cytoplasm 100 2 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota DENND3 HGNC:29134 DENN/MADD domain containing 3 A2RUS2 cytoplasm 10 1 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota DENND4A HGNC:24321 DENN/MADD domain containing 4A Q7Z401 Nucleus (Probable). Nucleus (GO:0005634) 12906859,17081983 golgi apparatus 48 2 nucleus nucleus Bilateria Eukaryota Eukaryota DENND4B HGNC:29044 DENN/MADD domain containing 4B O75064 Golgi apparatus. golgi apparatus 100 3 golgi apparatus golgi apparatus NA NA Eukaryota DENND4C HGNC:26079 DENN/MADD domain containing 4C Q5VZ89 Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles. Nucleus (GO:0005634) 17081983 golgi apparatus 47 2 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota DENND5A HGNC:19344 DENN/MADD domain containing 5A Q6IQ26 Cytoplasm (GO:0005737) 17081983 golgi apparatus 13 1 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DENND5B HGNC:28338 DENN/MADD domain containing 5B Q6ZUT9 Membrane; Single-pass membrane protein (Potential). nucleus 20 1 nucleus nucleus Bilateria Eukaryota Eukaryota DENND6A HGNC:26635 DENN/MADD domain containing 6A Q8IWF6 Recycling endosome. Cytoplasm. nucleus 55 0 cytoplasm. endosome multiple Eukaryota Eukaryota Eukaryota DENND6B HGNC:32690 DENN/MADD domain containing 6B Q8NEG7 Recycling endosome (Potential). Cytoplasm (Potential). nucleus 51 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DENR HGNC:2769 density-regulated protein O43583 Nucleus (GO:0005634) 17081983 cytoplasm 23 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota DEPDC1 HGNC:22949 DEP domain containing 1 Q5TB30 Nucleus. Note=Co-localizes with ZNF224 at the nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa DEPDC1B HGNC:24902 DEP domain containing 1B Q8WUY9 nucleus 44 0 nucleus nucleus Chordata Chordata Eukaryota DEPDC4 HGNC:22952 DEP domain containing 4 Q8N2C3 nucleus 8 0 nucleus nucleus Homininae Mammalia Eumetazoa DEPDC5 HGNC:18423 DEP domain containing 5 O75140 Cytoplasm, cytosol (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasm (GO:0005737) 17081983 cytoplasm 94 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota DEPDC7 HGNC:29899 DEP domain containing 7 Q96QD5 nucleus 8 0 nucleus nucleus Deuterostomia Deuterostomia Eumetazoa DEPTOR HGNC:22953 DEP domain containing MTOR-interacting protein Q8TB45 cytoplasm 63 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DERA HGNC:24269 deoxyribose-phosphate aldolase (putative) Q9Y315 cytoplasm 69 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DERL1 HGNC:28454 derlin 1 Q9BUN8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15215855 endoplasmic reticulum membrane 100 6 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Eukaryota Eukaryota DERL2 HGNC:17943 derlin 2 Q9GZP9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15215855 endoplasmic reticulum membrane 100 6 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Eukaryota DERL3 HGNC:14236 derlin 3 Q96Q80 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane (GO:0005789) 15215855 endoplasmic reticulum membrane 100 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Amniota Eukaryota DES HGNC:2770 desmin P17661 Cytoplasm. Cytoplasm (GO:0005737) 8186663 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa DESI1 HGNC:24577 desumoylating isopeptidase 1 Q6ICB0 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota DESI2 HGNC:24264 desumoylating isopeptidase 2 Q9BSY9 Cytoplasm (By similarity). cytoplasm 96 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DET1 HGNC:25477 de-etiolated homolog 1 (Arabidopsis) Q7L5Y6 Nucleus (Probable). nucleus 18 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota DEXI HGNC:13267 Dexi homolog (mouse) O95424 Integral to membrane (GO:0016021) secreted 17 1 secreted secreted Theria Euteleostomi Craniata DFFA HGNC:2772 DNA fragmentation factor, 45kDa, alpha polypeptide O00273 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9108473,11004695 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa DFFB HGNC:2773 DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) O76075 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9108473,9108473 nucleus 60 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa DFNA5 HGNC:2810 deafness, autosomal dominant 5 O60443 cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa DFNB31 HGNC:16361 deafness, autosomal recessive 31 Q9P202 Cytoplasm (By similarity). Cell projection, stereocilium (By similarity). Cell projection, growth cone (By similarity). Note=Detected at the level of stereocilia in inner outer hair cells of the cochlea and vestibule. Co-localizes with the growing ends of actin filaments (By similarity). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (). Cytoskeleton (GO:0005856); Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12641734,15590698,12641734,15590698,15590698 cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa DFNB59 HGNC:29502 deafness, autosomal recessive 59 Q0ZLH3 Nucleus (GO:0005634) 16804542 cytoplasm 10 0 nucleus nucleus Amniota Euteleostomi Eumetazoa DGAT1 HGNC:2843 diacylglycerol O-acyltransferase 1 O75907 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 9789033,10802663 endoplasmic reticulum membrane 87 9 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota NA DGAT2 HGNC:16940 diacylglycerol O-acyltransferase 2 Q96PD7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet (By similarity). Endoplasmic reticulum (GO:0005783) 14521909 endoplasmic reticulum membrane 39 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Euteleostomi Cell.Organisms DGAT2L6 HGNC:23250 diacylglycerol O-acyltransferase 2-like 6 Q6ZPD8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Eukaryota DGCR14 HGNC:16817 DiGeorge syndrome critical region gene 14 Q96DF8 Nucleus (By similarity). Nucleus (GO:0005634) 9499415,17081983 nucleus 92 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota DGCR2 HGNC:2845 DiGeorge syndrome critical region gene 2 P98153 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 7655455,17081983 plasma membrane 40 1 nucleus. plasma membrane multiple Euteleostomi Deuterostomia Eumetazoa DGCR6 HGNC:2846 DiGeorge syndrome critical region gene 6 Q14129 Nucleus. Note=Predominantly nuclear. nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa DGCR6L HGNC:18551 DiGeorge syndrome critical region gene 6-like Q9BY27 Nucleus. Note=Predominantly nuclear. nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa DGCR8 HGNC:2847 DGCR8 microprocessor complex subunit Q8WYQ5 Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa DGKA HGNC:2849 diacylglycerol kinase, alpha 80kDa P23743 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856); Perinuclear region (GO:0048471) 8626603,8626603,11285286,12626538,8626603,8626603 cytoplasm 38 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota DGKB HGNC:2850 diacylglycerol kinase, beta 90kDa Q9Y6T7 Cytoplasm (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11719522,11719522 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DGKD HGNC:2851 diacylglycerol kinase, delta 130kDa Q16760 Isoform 2: Cytoplasm. Isoform 1: Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023);Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023); Nucleus (GO:0005634);Cytoplasmic vesicle (GO:0016023) 12200442,12200442/11809841,12200442,11309392/12200442 cytoplasm 20 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Cell.Organisms DGKE HGNC:2852 diacylglycerol kinase, epsilon 64kDa P52429 Membrane; Multi-pass membrane protein (Potential). nucleus 23 1 nucleus nucleus Euteleostomi Bilateria Cell.Organisms DGKG HGNC:2853 diacylglycerol kinase, gamma 90kDa P49619 Cytoplasm. Membrane. Note=Can be loosely bound to the membranes. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12732202,12732202 cytoplasm 32 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DGKH HGNC:2854 diacylglycerol kinase, eta Q86XP1 Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli. Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS. Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023); Endosome (GO:0005768) 12810723,12810723,12810723 cytoplasm 17 0 cytoplasm. endosome multiple Bilateria Eukaryota Cell.Organisms DGKI HGNC:2855 diacylglycerol kinase, iota O75912 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9830018,9830018 nucleus 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms DGKK HGNC:32395 diacylglycerol kinase, kappa Q5KSL6 Cytoplasm. Membrane; Peripheral membrane protein. secreted 20 0 cytoplasm cytoplasm Bilateria Eukaryota NA DGKQ HGNC:2856 diacylglycerol kinase, theta 110kDa P52824 Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10066731,10066731,12799190 cytoplasm 28 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota DGKZ HGNC:2857 diacylglycerol kinase, zeta Q13574 Cytoplasm. Nucleus. Cell membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytosol (GO:0005829); Microsome (GO:0005792) 11352924,14551255,12015310,11352924,14551255,12015310,17351151,17351151,17351151 nucleus 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms DGUOK HGNC:2858 deoxyguanosine kinase Q16854 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10951205,11294860 mitochondrion 100 0 cytoplasm. mitochondrion multiple Euteleostomi Cell.Organisms Cell.Organisms DHCR24 HGNC:2859 24-dehydrocholesterol reductase Q15392 Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 11519011,11519011 vacuole 15 3 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus membrane. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms DHCR7 HGNC:2860 7-dehydrocholesterol reductase Q9UBM7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome (GO:0005777); Endoplasmic reticulum (GO:0005783) 11111101,15561729 endoplasmic reticulum membrane 100 11 endoplasmic reticulum. endoplasmic reticulum membrane. peroxisome multiple Deuterostomia Eukaryota Cell.Organisms DHDDS HGNC:20603 dehydrodolichyl diphosphate synthase Q86SQ9 Endoplasmic reticulum membrane; Peripheral membrane protein. Note=colocalizes with calnexin. Endoplasmic reticulum (GO:0005783) 14652022 mitochondrion 28 0 endoplasmic reticulum endoplasmic reticulum Cell.Organisms Cell.Organisms Cell.Organisms DHDH HGNC:17887 dihydrodiol dehydrogenase (dimeric) Q9UQ10 cytoplasm 69 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms DHFR HGNC:2861 dihydrofolate reductase P00374 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8527095,2592384 cytoplasm 31 0 cytoplasm. nucleus multiple NA NA Cell.Organisms DHFRL1 HGNC:27309 dihydrofolate reductase-like 1 Q86XF0 Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. cytoplasm 27 0 mitochondrion mitochondrion Homininae Homininae Cell.Organisms DHH HGNC:2865 desert hedgehog O43323 Desert hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side (By similarity). Desert hedgehog protein C-product: Secreted, extracellular space (By similarity). Note=The C-terminal peptide diffuses from the cell (By similarity). Extracellular (GO:0005576) 9524572 secreted 44 0 secreted secreted Bilateria Bilateria Holozoa DHODH HGNC:2867 dihydroorotate dehydrogenase (quinone) Q02127 Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion (GO:0005739); Mitochondrial intermembrane space (GO:0005758); Mitochondrial membrane (GO:0005740) 11248707,12052230,10727948,10727948,11012787,10727948 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms DHPS HGNC:2869 deoxyhypusine synthase P49366 cytoplasm 42 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DHRS1 HGNC:16445 dehydrogenase/reductase (SDR family) member 1 Q96LJ7 Endoplasmic reticulum (GO:0005783) mitochondrion 14 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms DHRS11 HGNC:28639 dehydrogenase/reductase (SDR family) member 11 Q6UWP2 Secreted (Potential). cytoplasm 14 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms NA DHRS12 HGNC:25832 dehydrogenase/reductase (SDR family) member 12 A0PJE2 endoplasmic reticulum membrane 17 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Eukaryota Cell.Organisms DHRS13 HGNC:28326 dehydrogenase/reductase (SDR family) member 13 Q6UX07 Secreted (Potential). endoplasmic reticulum membrane 34 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Cell.Organisms DHRS2 HGNC:18349 dehydrogenase/reductase (SDR family) member 2 Q13268 Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1847869,7556196,11997086,11997086 peroxisome 51 0 cytoplasm. mitochondrion. nucleus multiple Human Cell.Organisms Cell.Organisms DHRS3 HGNC:17693 dehydrogenase/reductase (SDR family) member 3 O75911 Membrane; Multi-pass membrane protein (Potential). peroxisome 11 2 peroxisome peroxisome Euteleostomi Euteleostomi Cell.Organisms DHRS4 HGNC:16985 dehydrogenase/reductase (SDR family) member 4 Q9BTZ2 Peroxisome. Isoform 7: Nucleus. Peroxisome (GO:0005777) 10333503 peroxisome 82 0 nucleus. peroxisome multiple Bilateria Cell.Organisms Cell.Organisms DHRS4L2 HGNC:19731 dehydrogenase/reductase (SDR family) member 4 like 2 Q6PKH6 Secreted (Potential). peroxisome 72 0 peroxisome peroxisome Human Catarrhini Cell.Organisms DHRS7 HGNC:21524 dehydrogenase/reductase (SDR family) member 7 Q9Y394 endoplasmic reticulum membrane 16 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms DHRS7B HGNC:24547 dehydrogenase/reductase (SDR family) member 7B Q6IAN0 Peroxisome membrane; Single-pass type II membrane protein (Potential). Cytosol (GO:0005829) 15561729 plasma membrane 13 2 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DHRS7C HGNC:32423 dehydrogenase/reductase (SDR family) member 7C A6NNS2 Secreted (Potential). mitochondrion 12 2 mitochondrion mitochondrion Euteleostomi Euteleostomi Cell.Organisms DHRS9 HGNC:16888 dehydrogenase/reductase (SDR family) member 9 Q9BPW9 Microsome membrane. Endoplasmic reticulum membrane (Potential). Note=Associated with microsomal membranes. Integral to membrane (GO:0016021) 11294878 cytoplasm 32 1 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms DHRSX HGNC:18399 dehydrogenase/reductase (SDR family) X-linked Q8N5I4 endoplasmic reticulum membrane 24 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Deuterostomia Cell.Organisms DHTKD1 HGNC:23537 dehydrogenase E1 and transketolase domain containing 1 Q96HY7 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms DHX15 HGNC:2738 DEAH (Asp-Glu-Ala-His) box helicase 15 O43143 Nucleus. Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9388478,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DHX16 HGNC:2739 DEAH (Asp-Glu-Ala-His) box polypeptide 16 O60231 Nucleus. Nucleus (GO:0005634) 9547260 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms NA DHX29 HGNC:15815 DEAH (Asp-Glu-Ala-His) box polypeptide 29 Q7Z478 Cytoplasm (Probable). cytoplasm 18 2 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms DHX30 HGNC:16716 DEAH (Asp-Glu-Ala-His) box helicase 30 Q7L2E3 Isoform 2: Cytoplasm. Isoform 1: Cytoplasm. Mitochondrion. Cytoplasm (Potential). Mitochondrion matrix, mitochondrion nucleoid. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 17255935,15561729,15598749 nucleus 22 1 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Deuterostomia Cell.Organisms DHX32 HGNC:16717 DEAH (Asp-Glu-Ala-His) box polypeptide 32 Q7L7V1 Nucleus. Mitochondrion. Nucleus (GO:0005634) nucleus 27 0 mitochondrion. nucleus multiple Chordata Chordata Cell.Organisms DHX33 HGNC:16718 DEAH (Asp-Glu-Ala-His) box polypeptide 33 Q9H6R0 Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions. Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,15561729 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms DHX34 HGNC:16719 DEAH (Asp-Glu-Ala-His) box polypeptide 34 Q14147 nucleus 25 3 nucleus nucleus Bilateria Eukaryota Cell.Organisms DHX35 HGNC:15861 DEAH (Asp-Glu-Ala-His) box polypeptide 35 Q9H5Z1 nucleus 35 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DHX36 HGNC:14410 DEAH (Asp-Glu-Ala-His) box polypeptide 36 Q9H2U1 Nucleus. Cytoplasm. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Plasma membrane (GO:0005886) 12198572 nucleus 25 1 cytoplasm. nucleus. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms DHX37 HGNC:17210 DEAH (Asp-Glu-Ala-His) box polypeptide 37 Q8IY37 Nucleolus (GO:0005730) 15635413 nucleus 28 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DHX38 HGNC:17211 DEAH (Asp-Glu-Ala-His) box polypeptide 38 Q92620 Nucleus (By similarity). Nucleus (GO:0005634) 9342318 nucleus 41 1 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DHX40 HGNC:18018 DEAH (Asp-Glu-Ala-His) box polypeptide 40 Q8IX18 Nucleus (GO:0005634) 8707840 nucleus 30 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms DHX57 HGNC:20086 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 Q6P158 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DHX58 HGNC:29517 DEXH (Asp-Glu-X-His) box polypeptide 58 Q96C10 Cytoplasm. Cytoplasm (GO:0005737) 11735219 cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota NA DHX8 HGNC:2749 DEAH (Asp-Glu-Ala-His) box polypeptide 8 Q14562 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8608946,15635413 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms DHX9 HGNC:2750 DEAH (Asp-Glu-Ala-His) box helicase 9 Q08211 Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasmic vesicle (GO:0016023); Integral to membrane (GO:0016021) 15034300,9111062,9480750,8344961,1537828,7608213,14704337,12243751,15034300,15652821,15561729,12243751,15635413,11790298,8690889,8690889 nucleus 40 2 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms DIABLO HGNC:21528 diablo, IAP-binding mitochondrial protein Q9NR28 Mitochondrion. Note=Released into the cytosol when cells undergo apoptosis. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10929711,15178455,15541727,15598749,10929711,15178455,15541727 mitochondrion 100 0 cytoplasm. mitochondrion multiple Euteleostomi Deuterostomia Bilateria DIAPH1 HGNC:2876 diaphanous-related formin 1 O60610 Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11171383,15598749 cytoplasm 33 0 cytoplasm. mitochondrion multiple Bilateria Eukaryota Eukaryota DIAPH2 HGNC:2877 diaphanous-related formin 2 O60879 Isoform 3: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes. Cytoplasm (GO:0005737); Endosome (GO:0005768); Nucleus (GO:0005634) 12577064,12577064,17081983 cytoplasm 51 0 cytoplasm. endosome. nucleus multiple Bilateria Eukaryota Eukaryota DIAPH3 HGNC:15480 diaphanous-related formin 3 Q9NSV4 Cytoplasm, cytosol. Note=During mitosis, co- localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DICER1 HGNC:17098 dicer 1, ribonuclease type III Q9UPY3 Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 12527779,16424907,12411504 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Opisthokonta Cell.Organisms Cell.Organisms DIDO1 HGNC:2680 death inducer-obliterator 1 Q9BTC0 Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10393935,17081983,10393935,17081983/17081983,17081983 nucleus 41 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota DIEXF HGNC:28440 digestive organ expansion factor homolog (zebrafish) Q68CQ4 Nucleus (By similarity). Nucleus, nucleolus. nucleus 44 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DIMT1 HGNC:30217 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) Q9UNQ2 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms DIO1 HGNC:2883 deiodinase, iodothyronine, type I P49895 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 7744884 endoplasmic reticulum membrane 77 1 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms DIO2 HGNC:2884 deiodinase, iodothyronine, type II Q92813 Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane (GO:0005789); Perinuclear region (GO:0048471) 11089566,12865408,11089566 endoplasmic reticulum membrane 32 2 cytoplasm. endoplasmic reticulum membrane multiple Human Euteleostomi Cell.Organisms DIO3 HGNC:2885 deiodinase, iodothyronine, type III P55073 Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768) 12419801,12419801 endoplasmic reticulum membrane 36 0 endosome. endosome membrane. plasma membrane multiple NA NA Cell.Organisms DIP2A HGNC:17217 DIP2 disco-interacting protein 2 homolog A (Drosophila) Q14689 Nucleus (Potential). Nucleus (GO:0005634) 12137943 peroxisome 13 1 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms DIP2B HGNC:29284 DIP2 disco-interacting protein 2 homolog B (Drosophila) Q9P265 peroxisome 13 0 peroxisome peroxisome Opisthokonta Cell.Organisms Cell.Organisms DIP2C HGNC:29150 DIP2 disco-interacting protein 2 homolog C (Drosophila) Q9Y2E4 peroxisome 8 1 peroxisome peroxisome Opisthokonta Cell.Organisms Cell.Organisms DIRAS1 HGNC:19127 DIRAS family, GTP-binding RAS-like 1 O95057 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 12194967,12194967 cytoplasm 21 0 cytoplasm cytoplasm Euarchontoglires Tetrapoda Cell.Organisms DIRAS2 HGNC:19323 DIRAS family, GTP-binding RAS-like 2 Q96HU8 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 12194967,12194967 cytoplasm 22 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms DIRAS3 HGNC:687 DIRAS family, GTP-binding RAS-like 3 O95661 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) 12771940 cytoplasm 15 0 cytoplasm cytoplasm Catarrhini Catarrhini Cell.Organisms DIRC1 HGNC:15760 disrupted in renal carcinoma 1 Q969H9 secreted 37 0 secreted secreted Homininae Homininae Homo DIRC2 HGNC:16628 disrupted in renal carcinoma 2 Q96SL1 Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 12 12 lysosome membrane lysosome membrane Deuterostomia Eukaryota Cell.Organisms DIS3 HGNC:20604 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease Q9Y2L1 Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 cytoplasm 26 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms DIS3L HGNC:28698 DIS3 like exosome 3'-5' exoribonuclease Q8TF46 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DIS3L2 HGNC:28648 DIS3 like 3'-5' exoribonuclease 2 Q8IYB7 Cytoplasm. Cytoplasm, P-body. cytoplasm 100 0 cytoplasm cytoplasm Human Eukaryota Cell.Organisms DISC1 HGNC:2888 disrupted in schizophrenia 1 Q9NRI5 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813) 12812986,12812986,12812986,15094396 cytoplasm 16 0 cytoplasm. nucleus multiple Theria Euteleostomi Opisthokonta DISP1 HGNC:19711 dispatched homolog 1 (Drosophila) Q96F81 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) vacuole membrane 14 12 vacuole membrane vacuole membrane Bilateria Bilateria Cell.Organisms DISP2 HGNC:19712 dispatched homolog 2 (Drosophila) A7MBM2 Membrane; Multi-pass membrane protein (Potential). plasma membrane 94 12 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa DIXDC1 HGNC:23695 DIX domain containing 1 Q155Q3 Cytoplasm, cytosol. Isoform 1: Cell junction, focal adhesion. Isoform 2: Cytoplasm. Cytoplasm (GO:0005737) 12792787 cytoplasm 28 0 cytoplasm cytoplasm Deuterostomia Deuterostomia NA DKC1 HGNC:2890 dyskeratosis congenita 1, dyskerin O60832 Isoform 1: Nucleus, nucleolus. Nucleus, Cajal body. Isoform 3: Cytoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10556300,15561729,9590285,11790298,15635413 nucleus 90 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms NA DKK1 HGNC:2891 dickkopf WNT signaling pathway inhibitor 1 O94907 Secreted. Extracellular (GO:0005576) 11357136,10383463 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa DKK2 HGNC:2892 dickkopf WNT signaling pathway inhibitor 2 Q9UBU2 Secreted. Extracellular (GO:0005576) 11357136 secreted 100 0 secreted secreted Tetrapoda Deuterostomia Deuterostomia DKK3 HGNC:2893 dickkopf WNT signaling pathway inhibitor 3 Q9UBP4 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10570958,15516983,15516983 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Eumetazoa DKK4 HGNC:2894 dickkopf WNT signaling pathway inhibitor 4 Q9UBT3 Secreted. Extracellular (GO:0005576) 10570958 secreted 100 0 secreted secreted Mammalia Mammalia Deuterostomia DKKL1 HGNC:16528 dickkopf-like 1 Q9UK85 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10570958,17081983,17081983 secreted 100 0 cytoplasm. nucleus. secreted multiple Eutheria Eutheria Tetrapoda DLAT HGNC:2896 dihydrolipoamide S-acetyltransferase P10515 Mitochondrion matrix. Mitochondrion (GO:0005739) 3174635,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms NA DLC1 HGNC:2897 deleted in liver cancer 1 Q96QB1 Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery. Cytoplasm (GO:0005737) 10844022,14647417 secreted 36 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota DLD HGNC:2898 dihydrolipoamide dehydrogenase P09622 Mitochondrion matrix. Mitochondrion (GO:0005739) 9040023,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms DLEC1 HGNC:2899 deleted in lung and esophageal cancer 1 Q9Y238 Cytoplasm. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983/10213508 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota DLEU7 HGNC:17567 deleted in lymphocytic leukemia, 7 Q6UYE1 nucleus 45 0 nucleus nucleus Euarchontoglires Tetrapoda Euteleostomi DLG1 HGNC:2900 discs, large homolog 1 (Drosophila) Q12959 Membrane; Peripheral membrane protein (By similarity). Basolateral cell membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse. Cell membrane, sarcolemma. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Membrane fraction (GO:0005624); Cell junction (GO:0030054) 17081983,17081983/8825652,18793635,12050163,18793635,18793635,18793635 cytoplasm 17 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms DLG2 HGNC:2901 discs, large homolog 2 (Drosophila) Q15700 Membrane; Lipid-anchor (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Concentrated in soma and postsynaptic density of a subset of neurons (By similarity). Plasma membrane (GO:0005886) 11997254 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms DLG3 HGNC:2902 discs, large homolog 3 (Drosophila) Q92796 Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 8702950,10026200,12738960,12738960 cytoplasm 18 0 cytoplasm. endoplasmic reticulum multiple Bilateria Bilateria Cell.Organisms DLG4 HGNC:2903 discs, large homolog 4 (Drosophila) P78352 Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell junction, synapse, synaptosome (By similarity). Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Dendrite (GO:0030425); Synapse (GO:0045202) 12435606,12435606,15978582,15978582 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms DLG5 HGNC:2904 discs, large homolog 5 (Drosophila) Q8TDM6 Cell junction. Cell membrane; Peripheral membrane protein. Note=Localized at sites of cell-cell contact. Nucleus (GO:0005634);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 17081983/9738934,9738934 cytoplasm 8 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms DLGAP1 HGNC:2905 discs, large (Drosophila) homolog-associated protein 1 O14490 Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Found in postsynaptic density of neuronal cells (By similarity). Synapse (GO:0045202) 9024696,9286858 nucleus 89 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa DLGAP2 HGNC:2906 discs, large (Drosophila) homolog-associated protein 2 Q9P1A6 Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity). Plasma membrane (GO:0005886) nucleus 88 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa DLGAP3 HGNC:30368 discs, large (Drosophila) homolog-associated protein 3 O95886 Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity). Nucleus (GO:0005634) 9115257 nucleus 83 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa DLGAP4 HGNC:24476 discs, large (Drosophila) homolog-associated protein 4 Q9Y2H0 Membrane; Peripheral membrane protein (By similarity). Synapse (GO:0045202); Cytosol (GO:0005829); Plasma membrane (GO:0005886) 9115257,9115257,9115257 nucleus 88 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA DLGAP5 HGNC:16864 discs, large (Drosophila) homolog-associated protein 5 Q15398 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. Centrosome (GO:0005813); Cytoplasm (GO:0005737); Microtubule (GO:0005874); Nucleus (GO:0005634) 12527899,12902344,15561729,17081983 nucleus 11 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Holozoa DLK1 HGNC:2907 delta-like 1 homolog (Drosophila) P80370 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11742219,7925474,7925474,10354070 plasma membrane 23 1 cytoplasm. plasma membrane. secreted multiple Amniota Euteleostomi Eukaryota DLK2 HGNC:21113 delta-like 2 homolog (Drosophila) Q6UY11 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 26 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Eukaryota DLL1 HGNC:2908 delta-like 1 (Drosophila) O00548 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Vesicle (None); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10079256,16857196,12794186,12794186 secreted 30 1 cytoplasm. nucleus. plasma membrane multiple Deuterostomia Bilateria Eukaryota DLL3 HGNC:2909 delta-like 3 (Drosophila) Q9NYJ7 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 10742114 plasma membrane 27 1 plasma membrane plasma membrane Theria Theria Eukaryota DLL4 HGNC:2910 delta-like 4 (Drosophila) Q9NR61 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 10837024 secreted 27 1 plasma membrane plasma membrane Deuterostomia Bilateria Eukaryota DLST HGNC:2911 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) P36957 Mitochondrion. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 2365294,1943690,9405249,3753002,3571202,9405249 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms DLX1 HGNC:2914 distal-less homeobox 1 P56177 Nucleus (Potential). Nucleus (GO:0005634) 14769946,14671321 nucleus 33 0 nucleus nucleus Bilateria Bilateria Eukaryota DLX2 HGNC:2915 distal-less homeobox 2 Q07687 Nucleus (Potential). Nucleus (GO:0005634) 12957859 nucleus 39 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota DLX3 HGNC:2916 distal-less homeobox 3 O60479 Nucleus (Potential). Nucleus (GO:0005634) 11113121 nucleus 40 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota DLX4 HGNC:2917 distal-less homeobox 4 Q92988 Nucleus (Potential). Nucleus (GO:0005634) 12820413 nucleus 32 0 nucleus nucleus Theria Theria Metazoa DLX5 HGNC:2918 distal-less homeobox 5 P56178 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10516593,10516593 nucleus 96 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eukaryota DLX6 HGNC:2919 distal-less homeobox 6 P56179 Nucleus (Potential). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Chordata Chordata Eukaryota DMAP1 HGNC:18291 DNA methyltransferase 1 associated protein 1 Q9NPF5 Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1. Nucleus (GO:0005634) 14734556,15367675,17081983 nucleus 11 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota DMBT1 HGNC:2926 deleted in malignant brain tumors 1 Q9UGM3 Secreted (By similarity). Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). Plasma membrane (GO:0005886); Endosome (GO:0005768); Extracellular (GO:0005576) 10485905,10485905,11007786,11751412,10485905 secreted 69 0 endosome. secreted multiple Tetrapoda Eukaryota Eukaryota DMBX1 HGNC:19026 diencephalon/mesencephalon homeobox 1 Q8NFW5 Nucleus (By similarity). Nucleus (GO:0005634) ,15890343 nucleus 32 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta DMC1 HGNC:2927 DNA meiotic recombinase 1 Q14565 Nucleus (Potential). Chromosome (By similarity). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms DMD HGNC:2928 dystrophin P11532 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). Cytoplasm (GO:0005737); Actin filament (GO:0005884); Plasma membrane (GO:0005886) 11796130,17081983,16000376,16000376 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota DMGDH HGNC:24475 dimethylglycine dehydrogenase Q9UI17 Mitochondrion. Mitochondrion (GO:0005739) 11231903 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms DMKN HGNC:25063 dermokine Q6E0U4 Secreted. Extracellular (GO:0005576) 15234001 secreted 100 0 secreted secreted Human Theria Mammalia DMP1 HGNC:2932 dentin matrix acidic phosphoprotein 1 Q13316 Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus. Extracellular (GO:0005576) 8509401 nucleus 29 0 cytoplasm. nucleus. secreted multiple Mammalia Mammalia Amniota DMPK HGNC:2933 dystrophia myotonica-protein kinase Q09013 Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side (By similarity). Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (Probable). Mitochondrion outer membrane; Single- pass type IV membrane protein (Probable). Sarcoplasmic reticulum membrane (By similarity). Cell membrane (By similarity). Cytoplasm, cytosol (By similarity). Isoform 1: Mitochondrion membrane. Isoform 3: Mitochondrion membrane. Cytoplasm (GO:0005737); Sarcoplasmic reticulum (GO:0016529) 10026240,10026240 cytoplasm 43 1 cytoplasm. endoplasmic reticulum. mitochondrion membrane. nucleus membrane multiple Theria Theria Cell.Organisms DMRT1 HGNC:2934 doublesex and mab-3 related transcription factor 1 Q9Y5R6 Nucleus (By similarity). Nucleus (GO:0005634) 11040213 nucleus 78 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa DMRT2 HGNC:2935 doublesex and mab-3 related transcription factor 2 Q9Y5R5 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 81 0 nucleus nucleus Mammalia Euteleostomi Eumetazoa DMRT3 HGNC:13909 doublesex and mab-3 related transcription factor 3 Q9NQL9 Nucleus (By similarity). nucleus 67 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa DMRTA1 HGNC:13826 DMRT-like family A1 Q5VZB9 Nucleus (Potential). nucleus 67 0 nucleus nucleus Chordata Chordata Eumetazoa DMRTA2 HGNC:13908 DMRT-like family A2 Q96SC8 Nucleus (Potential). nucleus 74 0 nucleus nucleus Theria Deuterostomia Eumetazoa DMRTB1 HGNC:13913 DMRT-like family B with proline-rich C-terminal, 1 Q96MA1 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Theria Amniota Eumetazoa DMRTC1 HGNC:13910 DMRT-like family C1 Q5HYR2 nucleus 63 0 nucleus nucleus Euarchontoglires Euarchontoglires Mammalia DMRTC1B HGNC:31686 DMRT-like family C1B Q5HYR2 nucleus 63 0 nucleus nucleus Euarchontoglires Euarchontoglires NA DMRTC2 HGNC:13911 DMRT-like family C2 Q8IXT2 Nucleus (Potential). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Mammalia Mammalia NA DMTF1 HGNC:14603 cyclin D binding myb-like transcription factor 1 Q9Y222 Nucleus. Nucleus (GO:0005634) 9786929 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota DMTN HGNC:3382 dematin actin binding protein Q08495 Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region (By similarity). Cytoplasm, cytoskeleton. Cell membrane. Membrane (By similarity). Endomembrane system. Cell projection (By similarity). Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuol in malaria- infected erythrocytes at late stages of plasmodium berghei or falciparum development. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8341682,7615546 cytoplasm 34 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota DMWD HGNC:2936 dystrophia myotonica, WD repeat containing Q09019 nucleus 21 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms DMXL1 HGNC:2937 Dmx-like 1 Q9Y485 nucleus 18 2 nucleus nucleus Bilateria Eukaryota Cell.Organisms DMXL2 HGNC:2938 Dmx-like 2 Q8TDJ6 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle (GO:0016023) 11809763 nucleus 17 2 nucleus nucleus Bilateria Eukaryota Cell.Organisms DNA2 HGNC:2939 DNA replication helicase/nuclease 2 P51530 Nucleus. Mitochondrion. Note=Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). Nucleus (GO:0005634) 16595800 nucleus 21 0 mitochondrion. nucleus multiple Opisthokonta Eukaryota Cell.Organisms DNAAF1 HGNC:30539 dynein, axonemal, assembly factor 1 Q8NEP3 Cell projection, cilium. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=In HEK293T cells, it is diffusely cytoplasmic and concentrates at the mitotic spindle poles, while in MDCK cells, it localizes in the cilium. In vivo, this protein is probably restricted to the cilium. cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms DNAAF2 HGNC:20188 dynein, axonemal, assembly factor 2 Q9NVR5 Cytoplasm. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota DNAAF3 HGNC:30492 dynein, axonemal, assembly factor 3 Q8N9W5 Cytoplasm (By similarity). cytoplasm 21 0 cytoplasm cytoplasm Eutheria Eukaryota Eukaryota DNAH1 HGNC:2940 dynein, axonemal, heavy chain 1 Q9P2D7 Cytoplasm, cytoskeleton, cilium axoneme (Potential). cytoplasm 31 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH10 HGNC:2941 dynein, axonemal, heavy chain 10 Q8IVF4 Cytoplasm, cytoskeleton, cilium axoneme (Potential). Cytoskeleton (GO:0005856) 11175280 cytoplasm 18 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH10OS HGNC:37121 dynein, axonemal, heavy chain 10 opposite strand P0CZ25 secreted 64 0 secreted secreted NA NA Homo DNAH11 HGNC:2942 dynein, axonemal, heavy chain 11 Q96DT5 Cytoplasm, cytoskeleton, cilium axoneme. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH12 HGNC:2943 dynein, axonemal, heavy chain 12 Q6ZR08 Cytoplasm, cytoskeleton, cilium axoneme (Potential). cytoplasm 36 3 cytoplasm cytoplasm Mammalia Deuterostomia NA DNAH14 HGNC:2945 dynein, axonemal, heavy chain 14 Q0VDD8 Cytoplasm, cytoskeleton, cilium axoneme (Potential). cytoplasm 21 3 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH17 HGNC:2946 dynein, axonemal, heavy chain 17 Q9UFH2 Cytoplasm, cytoskeleton, cilium axoneme (Potential). Extracellular (GO:0005576) 15822942 cytoplasm 54 0 secreted secreted Eukaryota Eukaryota Eukaryota DNAH2 HGNC:2948 dynein, axonemal, heavy chain 2 Q9P225 Cytoplasm, cytoskeleton, cilium axoneme (Potential). Cytoplasm (GO:0005737) 9256245 cytoplasm 22 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH3 HGNC:2949 dynein, axonemal, heavy chain 3 Q8TD57 Cytoplasm, cytoskeleton, cilium axoneme (Potential). Cytoplasm (GO:0005737) cytoplasm 42 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH5 HGNC:2950 dynein, axonemal, heavy chain 5 Q8TE73 Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9256245,6221120 cytoplasm 100 0 cytoplasm. secreted multiple Eukaryota Eukaryota Eukaryota DNAH6 HGNC:2951 dynein, axonemal, heavy chain 6 Q9C0G6 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 27 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH7 HGNC:18661 dynein, axonemal, heavy chain 7 Q8WXX0 Cytoplasm, cytoskeleton, cilium axoneme. Cell projection (GO:0042995) 11877439 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH8 HGNC:2952 dynein, axonemal, heavy chain 8 Q96JB1 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm (GO:0005737) 9373155 cytoplasm 92 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAH9 HGNC:2953 dynein, axonemal, heavy chain 9 Q9NYC9 Cytoplasm, cytoskeleton, cilium axoneme. Cell projection (GO:0042995); Cytoplasm (GO:0005737) 11839535,11104725,11104725 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DNAI1 HGNC:2954 dynein, axonemal, intermediate chain 1 Q9UI46 Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm (GO:0005737) 10577904 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota DNAI2 HGNC:18744 dynein, axonemal, intermediate chain 2 Q9GZS0 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 60 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms DNAJA1 HGNC:5229 DnaJ (Hsp40) homolog, subfamily A, member 1 P31689 Membrane; Lipid-anchor (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730); Golgi apparatus (GO:0005794); Acrosome (GO:0001669) 9839446,17081983,9839446,15635413,9839446,16225871 cytoplasm 36 0 golgi apparatus. lysosome. nucleus multiple Eukaryota Eukaryota Cell.Organisms DNAJA2 HGNC:14884 DnaJ (Hsp40) homolog, subfamily A, member 2 O60884 Membrane; Lipid-anchor (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Microsome (GO:0005792) 10816573,10816573,10816573,10816573 cytoplasm 38 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms DNAJA3 HGNC:11808 DnaJ (Hsp40) homolog, subfamily A, member 3 Q96EY1 Mitochondrion matrix. Cytoplasm, cytosol (By similarity). Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10411904,11679576,11679576,15561729 cytoplasm 27 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms DNAJA4 HGNC:14885 DnaJ (Hsp40) homolog, subfamily A, member 4 Q8WW22 Membrane; Lipid-anchor (Potential). Plasma membrane (GO:0005886) cytoplasm 38 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms DNAJB1 HGNC:5270 DnaJ (Hsp40) homolog, subfamily B, member 1 P25685 Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Cytosol (GO:0005829) 8670798,14752510,10816573,10816573,15561729 cytoplasm 46 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eutheria Eukaryota Cell.Organisms DNAJB11 HGNC:14889 DnaJ (Hsp40) homolog, subfamily B, member 11 Q9UBS4 Endoplasmic reticulum lumen. Note=Associated with the ER membrane in a C-terminally epitope-tagged construct. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10827079,12475965,15598749 endoplasmic reticulum 100 0 endoplasmic reticulum. mitochondrion multiple Bilateria Eukaryota Cell.Organisms DNAJB12 HGNC:14891 DnaJ (Hsp40) homolog, subfamily B, member 12 Q9NXW2 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum 38 1 endoplasmic reticulum endoplasmic reticulum Opisthokonta Eukaryota Cell.Organisms DNAJB13 HGNC:30718 DnaJ (Hsp40) homolog, subfamily B, member 13 P59910 cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms DNAJB14 HGNC:25881 DnaJ (Hsp40) homolog, subfamily B, member 14 Q8TBM8 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 42 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Eukaryota Cell.Organisms DNAJB2 HGNC:5228 DnaJ (Hsp40) homolog, subfamily B, member 2 P25686 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12754272,12754272 endoplasmic reticulum 50 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms DNAJB4 HGNC:14886 DnaJ (Hsp40) homolog, subfamily B, member 4 Q9UDY4 Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645. cytoplasm 48 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms DNAJB5 HGNC:14887 DnaJ (Hsp40) homolog, subfamily B, member 5 O75953 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11147971,11147971 cytoplasm 43 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms DNAJB6 HGNC:14888 DnaJ (Hsp40) homolog, subfamily B, member 6 O75190 Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12974469/12974469,17081983/10954706,10954706,15561729 endoplasmic reticulum 45 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms DNAJB7 HGNC:24986 DnaJ (Hsp40) homolog, subfamily B, member 7 Q7Z6W7 endoplasmic reticulum 42 0 endoplasmic reticulum endoplasmic reticulum Eutheria Eutheria Cell.Organisms DNAJB8 HGNC:23699 DnaJ (Hsp40) homolog, subfamily B, member 8 Q8NHS0 endoplasmic reticulum 42 0 endoplasmic reticulum endoplasmic reticulum Mammalia Eukaryota Cell.Organisms DNAJB9 HGNC:6968 DnaJ (Hsp40) homolog, subfamily B, member 9 Q9UBS3 Cytoplasm (By similarity). Nucleus (By similarity). Note=Stress induces its translocation to the nucleus (By similarity). Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 14516790,11836248,14516790,11525638 endoplasmic reticulum 93 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms DNAJC1 HGNC:20090 DnaJ (Hsp40) homolog, subfamily C, member 1 Q96KC8 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Nucleus membrane; Single- pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Endosome (GO:0005768); Cytoplasm (GO:0005737) 14668352,14668352,17081983,16225871,17081983 endoplasmic reticulum 39 2 cytoplasm. endoplasmic reticulum. endosome. nucleus. nucleus membrane multiple Bilateria Bilateria Cell.Organisms DNAJC10 HGNC:24637 DnaJ (Hsp40) homolog, subfamily C, member 10 Q8IXB1 Secreted (Potential). Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) 12411443 endoplasmic reticulum 100 1 endoplasmic reticulum endoplasmic reticulum Deuterostomia Eukaryota Cell.Organisms DNAJC11 HGNC:25570 DnaJ (Hsp40) homolog, subfamily C, member 11 Q9NVH1 cytoplasm 38 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms DNAJC12 HGNC:28908 DnaJ (Hsp40) homolog, subfamily C, member 12 Q9UKB3 endoplasmic reticulum 28 0 endoplasmic reticulum endoplasmic reticulum Chordata Bilateria Cell.Organisms DNAJC13 HGNC:30343 DnaJ (Hsp40) homolog, subfamily C, member 13 O75165 Endosome (GO:0005768) cytoplasm 33 2 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms DNAJC14 HGNC:24581 DnaJ (Hsp40) homolog, subfamily C, member 14 Q6Y2X3 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12768437,11331877,12446598,17081983,17081983 endoplasmic reticulum membrane 88 3 cytoplasm. endoplasmic reticulum. nucleus multiple Tetrapoda Bilateria Cell.Organisms DNAJC15 HGNC:20325 DnaJ (Hsp40) homolog, subfamily C, member 15 Q9Y5T4 Membrane; Single-pass membrane protein (Potential). mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Eukaryota Cell.Organisms Cell.Organisms DNAJC16 HGNC:29157 DnaJ (Hsp40) homolog, subfamily C, member 16 Q9Y2G8 Membrane; Single-pass type IV membrane protein (Potential). mitochondrion 47 1 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms DNAJC17 HGNC:25556 DnaJ (Hsp40) homolog, subfamily C, member 17 Q9NVM6 Nucleus (GO:0005634) 17081983 mitochondrion 28 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms DNAJC18 HGNC:28429 DnaJ (Hsp40) homolog, subfamily C, member 18 Q9H819 Membrane; Single-pass membrane protein (Potential). cytoplasm 35 1 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms DNAJC19 HGNC:30528 DnaJ (Hsp40) homolog, subfamily C, member 19 Q96DA6 Mitochondrion inner membrane; Single-pass membrane protein (Probable). Mitochondrial membrane (GO:0005740) mitochondrion membrane 51 0 mitochondrion membrane mitochondrion membrane Eukaryota Cell.Organisms Cell.Organisms DNAJC2 HGNC:13192 DnaJ (Hsp40) homolog, subfamily C, member 2 Q99543 Nucleus. Cytoplasm, cytosol. Ribosome (GO:0005840); Microtubule (GO:0005874); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 16002468,8885239,8885239,8885239,16002468 cytoplasm 38 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DNAJC21 HGNC:27030 DnaJ (Hsp40) homolog, subfamily C, member 21 Q5F1R6 endoplasmic reticulum membrane 36 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Cell.Organisms DNAJC22 HGNC:25802 DnaJ (Hsp40) homolog, subfamily C, member 22 Q8N4W6 Membrane; Multi-pass membrane protein (Potential). mitochondrion 35 7 mitochondrion mitochondrion Euteleostomi Bilateria Cell.Organisms DNAJC24 HGNC:26979 DnaJ (Hsp40) homolog, subfamily C, member 24 Q6P3W2 cytoplasm 81 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms DNAJC25 HGNC:34187 DnaJ (Hsp40) homolog, subfamily C , member 25 Q9H1X3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum 43 3 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms DNAJC27 HGNC:30290 DnaJ (Hsp40) homolog, subfamily C, member 27 Q9NZQ0 cytoplasm 34 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms DNAJC28 HGNC:1297 DnaJ (Hsp40) homolog, subfamily C, member 28 Q9NX36 mitochondrion 28 0 mitochondrion mitochondrion Euteleostomi Eukaryota NA DNAJC3 HGNC:9439 DnaJ (Hsp40) homolog, subfamily C, member 3 Q13217 Endoplasmic reticulum (By similarity). Cytoplasm (GO:0005737) 8666242 endoplasmic reticulum 96 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DNAJC30 HGNC:16410 DnaJ (Hsp40) homolog, subfamily C, member 30 Q96LL9 cytoplasm 36 1 cytoplasm cytoplasm Theria Bilateria NA DNAJC4 HGNC:5271 DnaJ (Hsp40) homolog, subfamily C, member 4 Q9NNZ3 Membrane; Single-pass membrane protein (Potential). mitochondrion 22 1 mitochondrion mitochondrion Theria Bilateria Cell.Organisms DNAJC5 HGNC:16235 DnaJ (Hsp40) homolog, subfamily C, member 5 Q9H3Z4 Membrane; Lipid-anchor (By similarity). Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasmic vesicle (GO:0016023); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Zymogen granule (GO:0042588) 12039948,12039948,12039948,16269331,16278343 cytoplasm 48 1 endoplasmic reticulum. melanosome. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms DNAJC5B HGNC:24138 DnaJ (Hsp40) homolog, subfamily C, member 5 beta Q9UF47 Membrane; Lipid-anchor. Note=May be associated with the trans-Golgi network (PubMed:17034881). cytoplasm 48 1 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms DNAJC5G HGNC:24844 DnaJ (Hsp40) homolog, subfamily C, member 5 gamma Q8N7S2 Membrane; Lipid-anchor (By similarity). cytoplasm 42 1 cytoplasm cytoplasm Euarchontoglires Eutheria Cell.Organisms DNAJC6 HGNC:15469 DnaJ (Hsp40) homolog, subfamily C, member 6 O75061 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11147971,11147971 cytoplasm 28 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota DNAJC7 HGNC:12392 DnaJ (Hsp40) homolog, subfamily C, member 7 Q99615 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11573955,12853476,11573955 cytoplasm 34 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA DNAJC8 HGNC:15470 DnaJ (Hsp40) homolog, subfamily C, member 8 O75937 Nucleolus (GO:0005730) 11790298,15635413 endoplasmic reticulum 33 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms DNAJC9 HGNC:19123 DnaJ (Hsp40) homolog, subfamily C, member 9 Q8WXX5 endoplasmic reticulum 29 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms DNAL1 HGNC:23247 dynein, axonemal, light chain 1 Q4LDG9 cytoplasm 43 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms DNAL4 HGNC:2955 dynein, axonemal, light chain 4 O96015 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota DNALI1 HGNC:14353 dynein, axonemal, light intermediate chain 1 O14645 cytoplasm 59 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DNASE1 HGNC:2956 deoxyribonuclease I P24855 Secreted. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. Extracellular (GO:0005576) 2349940 nucleus 33 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms DNASE1L1 HGNC:2957 deoxyribonuclease I-like 1 P49184 Endoplasmic reticulum. Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 10409440,10409440 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum multiple Theria Theria NA DNASE1L2 HGNC:2958 deoxyribonuclease I-like 2 Q92874 Secreted (Potential). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 11141064,11141064,11141064,11141064 nucleus 35 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Theria Deuterostomia Cell.Organisms DNASE1L3 HGNC:2959 deoxyribonuclease I-like 3 Q13609 Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus. Nucleus (GO:0005634) 12943533,11141064 nucleus 100 0 nucleus nucleus Chordata Chordata Cell.Organisms DNASE2 HGNC:2960 deoxyribonuclease II, lysosomal O00115 Lysosome. Lysosome (GO:0005764); Nucleus (GO:0005634) 9446563,11906178 secreted 26 0 lysosome. nucleus multiple Bilateria Eukaryota Cell.Organisms DNASE2B HGNC:28875 deoxyribonuclease II beta Q8WZ79 Lysosome (Probable). Nucleus (GO:0005634) secreted 18 0 lysosome lysosome Bilateria Eukaryota Cell.Organisms DND1 HGNC:23799 DND microRNA-mediated repression inhibitor 1 Q8IYX4 Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). Cytoplasm (GO:0005737) nucleus 31 0 cytoplasm. nucleus multiple NA NA Eukaryota DNER HGNC:24456 delta/notch-like EGF repeat containing Q8NFT8 Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). Plasma membrane (GO:0005886); Endosome (GO:0005768) 11950833,11950833 plasma membrane 100 1 endosome. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota DNHD1 HGNC:26532 dynein heavy chain domain 1 Q96M86 Microtubule (GO:0005874) 15561729 nucleus 3 8 nucleus nucleus Euteleostomi Euteleostomi Eukaryota DNLZ HGNC:33879 DNL-type zinc finger Q5SXM8 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota DNM1 HGNC:2972 dynamin 1 Q05193 Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. Endocytic vesicle (GO:0030139); Mitochondrion (GO:0005739); Cytoplasmic vesicle (GO:0016023); Cytoskeleton (GO:0005856); Cell surface (GO:0009986); Perinuclear region (GO:0048471); Microtubule (GO:0005874); Cytoplasm (GO:0005737) 16049941,11179417,15598749,11242086,8308025,15703209,15703209,15561729,17081983 cytoplasm 100 0 cytoplasm. mitochondrion multiple Bilateria Bilateria Eukaryota DNM1L HGNC:2973 dynamin 1-like O00429 Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O- GlcNAcylation and interaction with FIS1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9570752,9786947,9570752,9422767,9786947 cytoplasm 47 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Human Eukaryota Cell.Organisms DNM2 HGNC:2974 dynamin 2 P50570 Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Midbody. Note=Microtubule- associated. Also found in the postsynaptic density of neuronal cells. Cytoskeleton (GO:0005856); Perinuclear region (GO:0048471); Cell surface (GO:0009986); Mitochondrion (GO:0005739) 7590285,11583995,15703209,15703209,15598749 cytoplasm 77 0 cytoplasm. mitochondrion multiple Bilateria Bilateria Eukaryota DNM3 HGNC:29125 dynamin 3 Q9UQ16 Cytoplasm (Potential). Cytoplasm, cytoskeleton (Potential). Note=Microtubule-associated (Potential). cytoplasm 77 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota DNMBP HGNC:30373 dynamin binding protein Q6XZF7 Cytoplasm (By similarity). Golgi apparatus, Golgi stack (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses and Golgi stacks (By similarity). Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 14506234,14506234 cytoplasm 27 0 golgi apparatus. secreted multiple Deuterostomia Opisthokonta Eukaryota DNMT1 HGNC:2976 DNA (cytosine-5-)-methyltransferase 1 P26358 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 10888886,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms DNMT3A HGNC:2978 DNA (cytosine-5-)-methyltransferase 3 alpha Q9Y6K1 Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12145218,12145218 nucleus 52 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms DNMT3B HGNC:2979 DNA (cytosine-5-)-methyltransferase 3 beta Q9UBC3 Nucleus. Nucleus (GO:0005634) 12145218 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms DNMT3L HGNC:2980 DNA (cytosine-5-)-methyltransferase 3-like Q9UJW3 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12177302,12177302 nucleus 28 0 cytoplasm. nucleus multiple Theria Theria Holozoa DNPEP HGNC:2981 aspartyl aminopeptidase Q9ULA0 Cytoplasm. Cytoplasm (GO:0005737) 9632644 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms DNPH1 HGNC:21218 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 O43598 Cytoplasm. Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9271375,17081983,9271375 cytoplasm 25 0 cytoplasm. nucleus multiple Theria Cell.Organisms Cell.Organisms DNTT HGNC:2983 DNA nucleotidylexotransferase P04053 Nucleus. Nucleus (GO:0005634) 10570175,15356150 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota DNTTIP1 HGNC:16160 deoxynucleotidyltransferase, terminal, interacting protein 1 Q9H147 Nucleus. Nucleus (GO:0005634) 11473582,17081983 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa DNTTIP2 HGNC:24013 deoxynucleotidyltransferase, terminal, interacting protein 2 Q5QJE6 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15047147,12786946,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota DOC2A HGNC:2985 double C2-like domains, alpha Q14183 Lysosome (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein (Probable). Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles. Cytoplasmic vesicle (GO:0016023) 7826360,9115738 cytoplasm 23 0 cytoplasm cytoplasm Mammalia Euteleostomi Eukaryota DOC2B HGNC:2986 double C2-like domains, beta Q14184 Cytoplasm. Cytoplasmic granule (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Translocates to the plasma membrane in a calcium-dependent manner (By similarity). Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 7826360,9115738,9115738 secreted 26 0 cytoplasm cytoplasm NA NA NA DOCK1 HGNC:2987 dedicator of cytokinesis 1 Q14185 Cytoplasm (Probable). Membrane (Probable). Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8657152,8657152 cytoplasm 59 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK10 HGNC:23479 dedicator of cytokinesis 10 Q96BY6 cytoplasm 18 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK11 HGNC:23483 dedicator of cytokinesis 11 Q5JSL3 cytoplasm 21 2 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK2 HGNC:2988 dedicator of cytokinesis 2 Q92608 Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12393632,12393632 cytoplasm 46 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK3 HGNC:2989 dedicator of cytokinesis 3 Q8IZD9 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 10854253,10854253 cytoplasm 98 0 cytoplasm cytoplasm Bilateria Eukaryota NA DOCK4 HGNC:19192 dedicator of cytokinesis 4 Q8N1I0 Endomembrane system; Peripheral membrane protein. Cytoplasm, cytosol. Plasma membrane (GO:0005886) 12628187 cytoplasm 48 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK5 HGNC:23476 dedicator of cytokinesis 5 Q9H7D0 Cytoplasm (By similarity). cytoplasm 92 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK6 HGNC:19189 dedicator of cytokinesis 6 Q96HP0 Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface. cytoplasm 100 4 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK7 HGNC:19190 dedicator of cytokinesis 7 Q96N67 Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons. cytoplasm 60 2 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOCK8 HGNC:19191 dedicator of cytokinesis 8 Q8NF50 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 15304341,15304341,15304341 cytoplasm 42 2 cytoplasm. nucleus. plasma membrane multiple Bilateria Eukaryota Eukaryota DOCK9 HGNC:14132 dedicator of cytokinesis 9 Q9BZ29 Endomembrane system (Probable). Note=Associated with membranes (Probable). Plasma membrane (GO:0005886) cytoplasm 21 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DOHH HGNC:28662 deoxyhypusine hydroxylase/monooxygenase Q9BU89 cytoplasm 46 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms DOK1 HGNC:2990 docking protein 1, 62kDa (downstream of tyrosine kinase 1) Q99704 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10202139,11825908,11825908 cytoplasm 31 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa DOK2 HGNC:2991 docking protein 2, 56kDa O60496 Plasma membrane (GO:0005886) 11254695,11689432 nucleus 21 0 nucleus nucleus Mammalia Bilateria Holozoa DOK3 HGNC:24583 docking protein 3 Q7L591 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). nucleus 34 0 nucleus nucleus Amniota Euteleostomi Holozoa DOK4 HGNC:19868 docking protein 4 Q8TEW6 cytoplasm 45 0 cytoplasm cytoplasm Mammalia Mammalia Holozoa DOK5 HGNC:16173 docking protein 5 Q9P104 Integral to membrane (GO:0016021) 12730241 cytoplasm 47 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Holozoa DOK6 HGNC:28301 docking protein 6 Q6PKX4 Plasma membrane (GO:0005886) cytoplasm 40 0 cytoplasm cytoplasm Euarchontoglires Euteleostomi Holozoa DOK7 HGNC:26594 docking protein 7 Q18PE1 Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Note=Accumulates at neuromuscular junctions (By similarity). Cytoplasm (GO:0005737); Synapse (GO:0045202) 17439981,16794080 nucleus 56 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa DOLK HGNC:23406 dolichol kinase Q9UPQ8 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 20 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Eukaryota Eukaryota DOLPP1 HGNC:29565 dolichyldiphosphatase 1 Q86YN1 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 12198133 endoplasmic reticulum membrane 93 5 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota DONSON HGNC:2993 downstream neighbor of SON Q9NYP3 Nucleus (By similarity). nucleus 22 0 nucleus nucleus Bilateria Eukaryota Eukaryota DOPEY1 HGNC:21194 dopey family member 1 Q5JWR5 nucleus 77 9 nucleus nucleus Opisthokonta Eukaryota Eukaryota DOPEY2 HGNC:1291 dopey family member 2 Q9Y3R5 nucleus 80 7 nucleus nucleus Opisthokonta Eukaryota Eukaryota DOT1L HGNC:24948 DOT1-like histone H3K79 methyltransferase Q8TEK3 Nucleus. Nucleus (GO:0005634) 15561729 nucleus 100 0 nucleus nucleus Chordata Opisthokonta Opisthokonta DPAGT1 HGNC:2995 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) Q9H3H5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 3038274,12872255 endoplasmic reticulum membrane 100 10 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Cell.Organisms Cell.Organisms DPCD HGNC:24542 deleted in primary ciliary dyskinesia homolog (mouse) Q9BVM2 nucleus 30 0 nucleus nucleus Amniota Eukaryota Eukaryota DPCR1 HGNC:21666 diffuse panbronchiolitis critical region 1 Q3MIW9 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 19 1 plasma membrane plasma membrane Theria Theria NA DPEP1 HGNC:3002 dipeptidase 1 (renal) P16444 Apical cell membrane; Lipid-anchor, GPI- anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI- anchor. Note=Brush border membrane. Endoplasmic reticulum (GO:0005783); Zymogen granule (GO:0042588) 2303490,16278343 secreted 36 0 endoplasmic reticulum endoplasmic reticulum Opisthokonta Cell.Organisms Cell.Organisms DPEP2 HGNC:23028 dipeptidase 2 Q9H4A9 Membrane; Lipid-anchor, GPI-anchor (By similarity). secreted 61 1 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms DPEP3 HGNC:23029 dipeptidase 3 Q9H4B8 Membrane; Lipid-anchor, GPI-anchor (By similarity). secreted 86 1 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms DPF1 HGNC:20225 D4, zinc and double PHD fingers family 1 Q92782 Cytoplasm (Potential). Nucleus (Potential). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Eutheria Euteleostomi Eukaryota DPF2 HGNC:9964 D4, zinc and double PHD fingers family 2 Q92785 Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7961935,9680388,17081983,9680388 nucleus 39 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota DPF3 HGNC:17427 D4, zinc and double PHD fingers, family 3 Q92784 Nucleus (Probable). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Human Bilateria Eukaryota DPH1 HGNC:3003 diphthamide biosynthesis 1 Q9BZG8 Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10519411,11527402 cytoplasm 42 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms DPH2 HGNC:3004 DPH2 homolog (S. cerevisiae) Q9BQC3 cytoplasm 13 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms DPH3 HGNC:27717 diphthamide biosynthesis 3 Q96FX2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14980502,14980502 nucleus 33 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota DPH5 HGNC:24270 diphthamide biosynthesis 5 Q9H2P9 cytoplasm 49 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DPH6 HGNC:30543 diphthamine biosynthesis 6 Q7L8W6 cytoplasm 40 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DPH7 HGNC:25199 diphthamide biosynthesis 7 Q9BTV6 nucleus 28 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms DPM1 HGNC:3005 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit O60762 Endoplasmic reticulum. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9535917,17081983,17081983 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms DPM2 HGNC:3006 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit O94777 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 9724629 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Eukaryota Eukaryota DPM3 HGNC:3007 dolichyl-phosphate mannosyltransferase polypeptide 3 Q9P2X0 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 10835346,11420690,10835346,10835346 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. plasma membrane multiple Opisthokonta Eukaryota Eukaryota DPP10 HGNC:20823 dipeptidyl-peptidase 10 (non-functional) Q8N608 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Membrane fraction (GO:0005624);Nucleus (GO:0005634);Integral to membrane (GO:0016021) 14566338,14566338,12662155/17081983/ secreted 16 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms DPP3 HGNC:3008 dipeptidyl-peptidase 3 Q9NY33 Cytoplasm. Cytoplasm (GO:0005737) 2044841 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms DPP4 HGNC:3009 dipeptidyl-peptidase 4 P27487 Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12- dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12690074,12690074 secreted 20 1 plasma membrane. secreted multiple Opisthokonta Cell.Organisms Cell.Organisms DPP6 HGNC:3010 dipeptidyl-peptidase 6 P42658 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 12575952,11173531 secreted 12 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms DPP7 HGNC:14892 dipeptidyl-peptidase 7 Q9UHL4 Lysosome. Cytoplasmic vesicle. Secreted. Cytoplasm (GO:0005737); Lysosome (GO:0005764); Cytoplasmic vesicle (GO:0016023) 10567372,11173530,11067927,2207678,2727382,12005022,1515698,11067927 cytoplasm 17 0 cytoplasm. lysosome. secreted multiple Deuterostomia Eukaryota Eukaryota DPP8 HGNC:16490 dipeptidyl-peptidase 8 Q6V1X1 Cytoplasm. Cytoplasm (GO:0005737) 11012666 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DPP9 HGNC:18648 dipeptidyl-peptidase 9 Q86TI2 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 12459266,12662155 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DPPA2 HGNC:19197 developmental pluripotency associated 2 Q7Z7J5 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eutheria Eutheria Eumetazoa DPPA3 HGNC:19199 developmental pluripotency associated 3 Q6W0C5 Nucleus. Cytoplasm. Note=Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11900980,17143267,11900980,17143267 nucleus 82 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Boreoeutheria DPPA4 HGNC:19200 developmental pluripotency associated 4 Q7L190 Nucleus (By similarity). Nucleus (GO:0005634) 17081983 nucleus 45 0 nucleus nucleus Theria Theria Mammalia DPPA5 HGNC:19201 developmental pluripotency associated 5 A6NC42 Cytoplasm (By similarity). cytoplasm 58 0 cytoplasm cytoplasm Euarchontoglires Eutheria Eutheria DPRX HGNC:32166 divergent-paired related homeobox A6NFQ7 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus Homininae Homininae Eukaryota DPT HGNC:3011 dermatopontin Q07507 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10233760 secreted 95 0 secreted secreted Euteleostomi Euteleostomi Holozoa DPY19L1 HGNC:22205 dpy-19-like 1 (C. elegans) Q2PZI1 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 64 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota DPY19L2 HGNC:19414 dpy-19-like 2 (C. elegans) Q6NUT2 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 40 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota DPY19L3 HGNC:27120 dpy-19-like 3 (C. elegans) Q6ZPD9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 71 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Deuterostomia Eukaryota DPY19L4 HGNC:27829 dpy-19-like 4 (C. elegans) Q7Z388 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 67 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Holozoa DPY30 HGNC:24590 dpy-30 homolog (C. elegans) Q9C005 Nucleus. Golgi apparatus, trans-Golgi network. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity). nucleus 50 0 golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota DPYD HGNC:3012 dihydropyrimidine dehydrogenase Q12882 Cytoplasm. Cytoplasm (GO:0005737) 8221682 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DPYS HGNC:3013 dihydropyrimidinase Q14117 Cytoplasm (GO:0005737) 3931905 cytoplasm 52 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DPYSL2 HGNC:3014 dihydropyrimidinase-like 2 Q16555 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Microtubule (GO:0005874) 10770920,15652488,10770920,15652488 cytoplasm 97 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms DPYSL3 HGNC:3015 dihydropyrimidinase-like 3 Q14195 Cytoplasm (By similarity). Cell projection, growth cone (By similarity). Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12745088,17081983,17081983 cytoplasm 72 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms DPYSL4 HGNC:3016 dihydropyrimidinase-like 4 O14531 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10851247 cytoplasm 71 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms DPYSL5 HGNC:20637 dihydropyrimidinase-like 5 Q9BPU6 Cytoplasm (Probable). Cytoplasm (GO:0005737) 10851247 cytoplasm 40 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Cell.Organisms DQX1 HGNC:20410 DEAQ box RNA-dependent ATPase 1 Q8TE96 Nucleus (By similarity). nucleus 24 0 nucleus nucleus Theria Euteleostomi Cell.Organisms DR1 HGNC:3017 down-regulator of transcription 1, TBP-binding (negative cofactor 2) Q01658 Nucleus. Nucleus (GO:0005634) 9040789 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DRAM1 HGNC:25645 DNA-damage regulated autophagy modulator 1 Q8N682 Lysosome membrane; Multi-pass membrane protein. Lysosome (GO:0005764) 16839881 plasma membrane 9 6 lysosome. lysosome membrane multiple Chordata Chordata Eukaryota DRAM2 HGNC:28769 DNA-damage regulated autophagy modulator 2 Q6UX65 Lysosome membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 6 lysosome membrane lysosome membrane Bilateria Bilateria Eukaryota DRAP1 HGNC:3019 DR1-associated protein 1 (negative cofactor 2 alpha) Q14919 Nucleus (Potential). Nucleus (GO:0005634) 8972183,8608938 nucleus 32 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DRAXIN HGNC:25054 dorsal inhibitory axon guidance protein Q8NBI3 Secreted (Probable). secreted 48 0 secreted secreted Theria Euteleostomi Chordata DRC1 HGNC:24245 dynein regulatory complex subunit 1 homolog (Chlamydomonas) Q96MC2 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota DRD1 HGNC:3020 dopamine receptor D1 P21728 Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (By similarity). Plasma membrane (GO:0005886) 9457173 plasma membrane 76 7 plasma membrane plasma membrane Euteleostomi Bilateria Eumetazoa DRD2 HGNC:3023 dopamine receptor D2 P14416 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14704269,17380124 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Eumetazoa DRD3 HGNC:3024 dopamine receptor D3 P35462 Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co- localize in lipid rafts of renal proximal tubule cells. Plasma membrane (GO:0005886) 9457173,14519448 plasma membrane 100 7 plasma membrane plasma membrane Theria Bilateria Eumetazoa DRD4 HGNC:3025 dopamine receptor D4 P21917 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Eumetazoa DRD5 HGNC:3026 dopamine receptor D5 P21918 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9457173 plasma membrane 100 6 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa DRG1 HGNC:3029 developmentally regulated GTP binding protein 1 Q9Y295 Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes. Cytoplasm (GO:0005737) 1280421 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms DRG2 HGNC:3030 developmentally regulated GTP binding protein 2 P55039 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms DRGX HGNC:21536 dorsal root ganglia homeobox A6NNA5 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 29 0 nucleus nucleus Amniota Euteleostomi Eukaryota DRICH1 HGNC:28031 aspartate-rich 1 Q6PGQ1 nucleus 61 0 nucleus nucleus Catarrhini Catarrhini Boreoeutheria DROSHA HGNC:17904 drosha, ribonuclease type III Q9NRR4 Nucleus. Nucleus, nucleolus. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. Nucleus (GO:0005634); Nucleolus (GO:0005730) 14508493,10948199,17081983,10948199 nucleus 100 0 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms DRP2 HGNC:3032 dystrophin related protein 2 Q13474 Cytoplasm, cytoskeleton (Probable). Plasma membrane (GO:0005886) ,11430802, cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa DSC1 HGNC:3035 desmocollin 1 Q08554 Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Extracellular (GO:0005576) 11442746,11442746,16188874 plasma membrane 19 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms DSC2 HGNC:3036 desmocollin 2 Q02487 Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Plasma membrane (GO:0005886) 11853539,9443898 plasma membrane 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms DSC3 HGNC:3037 desmocollin 3 Q14574 Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11500511,7929347,7929347 plasma membrane 18 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms DSCAM HGNC:3039 Down syndrome cell adhesion molecule O60469 Isoform Long: Cell membrane; Single-pass type I membrane protein (Potential). Isoform Short: Secreted (Probable). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9426258,10925149,9426258 plasma membrane 11 0 secreted secreted Euteleostomi Bilateria Cell.Organisms DSCAML1 HGNC:14656 Down syndrome cell adhesion molecule like 1 Q8TD84 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11453658 plasma membrane 16 0 n/a n/a Euteleostomi Bilateria Cell.Organisms DSCC1 HGNC:24453 DNA replication and sister chromatid cohesion 1 Q9BVC3 Nucleus (By similarity). Nucleus (GO:0005634) 12930902,12766176 nucleus 78 0 nucleus nucleus Bilateria Eukaryota Eukaryota DSCR3 HGNC:3044 Down syndrome critical region gene 3 O14972 mitochondrion 34 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota DSCR4 HGNC:3045 Down syndrome critical region gene 4 P56555 nucleus 29 0 nucleus nucleus Homininae Homininae Homo DSE HGNC:21144 dermatan sulfate epimerase Q9UL01 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10679095,10679095 cytoplasm 33 2 endoplasmic reticulum. golgi apparatus multiple Deuterostomia Cell.Organisms Cell.Organisms DSEL HGNC:18144 dermatan sulfate epimerase-like Q8IZU8 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 43 2 golgi apparatus membrane golgi apparatus membrane Deuterostomia Cell.Organisms NA DSG1 HGNC:3048 desmoglein 1 Q02413 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 1754823,16188874 plasma membrane 13 1 plasma membrane. secreted multiple Amniota Amniota Cell.Organisms DSG2 HGNC:3049 desmoglein 2 Q14126 Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9579833,15561729,17081983,17081983 plasma membrane 17 1 cytoplasm. nucleus. plasma membrane multiple Theria Euteleostomi Cell.Organisms DSG3 HGNC:3050 desmoglein 3 P32926 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome (By similarity). Plasma membrane (GO:0005886) 8320263,11710914 plasma membrane 18 1 plasma membrane plasma membrane Amniota Amniota Cell.Organisms DSG4 HGNC:21307 desmoglein 4 Q86SJ6 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome (By similarity). Plasma membrane (GO:0005886) plasma membrane 17 1 plasma membrane plasma membrane Amniota Amniota Cell.Organisms DSN1 HGNC:16165 DSN1, MIS12 kinetochore complex component Q9H410 Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. Kinetochore (GO:0000776); Nucleus (GO:0005634) 15824131,15561729,15502821,17081983 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eumetazoa DSP HGNC:3052 desmoplakin P15924 Cell junction, desmosome. Cytoplasm, cytoskeleton. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Extracellular (GO:0005576); Cytoskeleton (GO:0005856) 1731325,11955647,15190119,11132762,15190119,11955647,12366696,17081983,11790298,16188874,15561729 cytoplasm 45 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Eukaryota DSPP HGNC:3054 dentin sialophosphoprotein Q9NZW4 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8995371 secreted 100 0 secreted secreted Theria Theria Eutheria DST HGNC:1090 dystonin Q03001 Cytoplasm, cytoskeleton. Isoform 1: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere, H zone (By similarity). Isoform 2: Cytoplasm, cytoskeleton (By similarity). Isoform 3: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Isoform 6: Nucleus (By similarity). Nucleus envelope. Membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Cytoplasm, cytoskeleton. Membrane; Single-pass membrane protein. Isoform 7: Cytoplasm, cytoskeleton. Cell projection, axon. Membrane. Isoform 8: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cell membrane; Lipid-anchor (By similarity). Nucleus (GO:0005634); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 14576348,17081983,2645368,2579167,3880796,11323216,2645368,14668477,17081983 cytoplasm 25 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Cell.Organisms DSTN HGNC:15750 destrin (actin depolymerizing factor) P60981 Nucleus (GO:0005634) 17081983 cytoplasm 24 0 nucleus nucleus Amniota Eukaryota Eukaryota DSTYK HGNC:29043 dual serine/threonine and tyrosine protein kinase Q6XUX3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms DTD1 HGNC:16219 D-tyrosyl-tRNA deacylase 1 Q8TEA8 Cytoplasm (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15653697,15653697 cytoplasm 25 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms DTD2 HGNC:20277 D-tyrosyl-tRNA deacylase 2 (putative) Q96FN9 Cytoplasm (Potential). Cytoplasm (GO:0005737) secreted 12 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms DTHD1 HGNC:37261 death domain containing 1 Q6ZMT9 cytoplasm 48 0 cytoplasm cytoplasm Theria Euteleostomi Eumetazoa DTL HGNC:30288 denticleless E3 ubiquitin protein ligase homolog (Drosophila) Q9NZJ0 Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear matrix- associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11278750,11278750 nucleus 12 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DTNA HGNC:3057 dystrobrevin, alpha Q9Y4J8 Cytoplasm. Cell junction, synapse. Cell membrane (By similarity). Note=In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane (By similarity). Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634) 11053293,12604589,12475945,8631824,12475945 cytoplasm 71 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Holozoa DTNB HGNC:3058 dystrobrevin, beta O60941 Cytoplasm. Cytoplasm (GO:0005737) 9395493,14600269 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa DTNBP1 HGNC:17328 dystrobrevin binding protein 1 Q96EV8 Isoform 1: Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Endoplasmic reticulum (By similarity). Nucleus. Isoform 2: Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse, postsynaptic cell membrane. Endoplasmic reticulum (By similarity). Nucleus. Isoform 3: Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse, postsynaptic cell membrane. Endoplasmic reticulum (By similarity). Note=Exclusivley cytoplasmic. Predominantly found in the postsynaptic density (PSD). Little association with synaptic vesicles. The BLOC-1 complex associates with the BLOC-2 complex in early endosome- associated tubules. Associated with the AP-3 complex at presynaptic terminals. Nucleus (GO:0005634); Axon (GO:0030424); Cytoplasm (GO:0005737) 11316798,11316798,11316798 cytoplasm 7 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa DTWD1 HGNC:30926 DTW domain containing 1 Q8N5C7 nucleus 76 0 nucleus nucleus Eukaryota Eukaryota Eukaryota DTWD2 HGNC:19334 DTW domain containing 2 Q8NBA8 nucleus 70 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms DTX1 HGNC:3060 deltex 1, E3 ubiquitin ligase Q86Y01 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endosome (GO:0005768) 11153911,9590294,11564735,17028573,17028573 cytoplasm 35 0 cytoplasm. endosome. nucleus multiple Euteleostomi Bilateria Eukaryota DTX2 HGNC:15973 deltex 2, E3 ubiquitin ligase Q86UW9 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. Cytoplasm (GO:0005737) 7671825 cytoplasm 34 0 cytoplasm. nucleus multiple NA NA Eukaryota DTX3 HGNC:24457 deltex 3, E3 ubiquitin ligase Q8N9I9 Cytoplasm (Probable). Cytoplasm (GO:0005737) 7671825 nucleus 36 0 cytoplasm cytoplasm Chordata Chordata Eukaryota DTX3L HGNC:30323 deltex 3 like, E3 ubiquitin ligase Q8TDB6 Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner. Nucleus (GO:0005634) cytoplasm 34 0 cytoplasm. nucleus multiple Human Amniota Eukaryota DTX4 HGNC:29151 deltex 4, E3 ubiquitin ligase Q9Y2E6 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 81505285 cytoplasm 33 1 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota DTYMK HGNC:3061 deoxythymidylate kinase (thymidylate kinase) P23919 Cytoplasm (GO:0005737) 2538159 cytoplasm 58 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DUOX1 HGNC:3062 dual oxidase 1 Q9NRD9 Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10806195,15561711 plasma membrane 100 7 endoplasmic reticulum. plasma membrane multiple Bilateria Eukaryota Cell.Organisms DUOX2 HGNC:13273 dual oxidase 2 Q9NRD8 Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11822874,10806195,11822874,16651268,15561711,16651268,16651268 plasma membrane 100 7 cytoplasm. endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms DUOXA1 HGNC:26507 dual oxidase maturation factor 1 Q1HG43 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 14670962 endoplasmic reticulum membrane 48 5 plasma membrane plasma membrane Bilateria Bilateria Holozoa DUOXA2 HGNC:32698 dual oxidase maturation factor 2 Q1HG44 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 16651268 endoplasmic reticulum membrane 100 5 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Bilateria Holozoa DUPD1 HGNC:23481 dual specificity phosphatase and pro isomerase domain containing 1 Q68J44 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms DUS1L HGNC:30086 dihydrouridine synthase 1-like (S. cerevisiae) Q6P1R4 mitochondrion 21 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms DUS2 HGNC:26014 dihydrouridine synthase 2 Q9NX74 Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) ,15994936 mitochondrion 19 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Cell.Organisms DUS3L HGNC:26920 dihydrouridine synthase 3-like (S. cerevisiae) Q96G46 Cytoplasm (GO:0005737) 17081983 nucleus 24 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms DUS4L HGNC:21517 dihydrouridine synthase 4-like (S. cerevisiae) O95620 mitochondrion 30 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms DUSP1 HGNC:3064 dual specificity phosphatase 1 P28562 Nucleus (By similarity). Nucleus (GO:0005634) 11062068 nucleus 74 0 nucleus nucleus Chordata Cell.Organisms Cell.Organisms DUSP10 HGNC:3065 dual specificity phosphatase 10 Q9Y6W6 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10391943,10597297,10391943,10597297 cytoplasm 22 0 cytoplasm. nucleus multiple Amniota Deuterostomia Cell.Organisms DUSP11 HGNC:3066 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) O75319 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9685386,15635413 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota DUSP12 HGNC:3067 dual specificity phosphatase 12 Q9UNI6 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10446167,10446167 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DUSP13 HGNC:19681 dual specificity phosphatase 13 Q6B8I1 Cytoplasm. Cytoplasm (GO:0005737) 15252030 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms DUSP14 HGNC:17007 dual specificity phosphatase 14 O95147 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11123293,11123293 nucleus 26 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DUSP15 HGNC:16236 dual specificity phosphatase 15 Q9H1R2 Cytoplasm (Probable). Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 15138252,15138252 nucleus 19 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms DUSP16 HGNC:17909 dual specificity phosphatase 16 Q9BY84 Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11359773,11489891,11489891 nucleus 24 1 cytoplasm. nucleus multiple Amniota Eukaryota Cell.Organisms DUSP18 HGNC:18484 dual specificity phosphatase 18 Q8NEJ0 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12408986,12408986 nucleus 20 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Cell.Organisms DUSP19 HGNC:18894 dual specificity phosphatase 19 Q8WTR2 Cytoplasm (GO:0005737) 11959861 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DUSP2 HGNC:3068 dual specificity phosphatase 2 Q05923 Nucleus. Nucleus (GO:0005634) 7681221 nucleus 100 0 nucleus nucleus Theria Euteleostomi Cell.Organisms DUSP21 HGNC:20476 dual specificity phosphatase 21 Q9H596 Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12408986,12408986 nucleus 15 0 cytoplasm. nucleus multiple Human Catarrhini Cell.Organisms DUSP22 HGNC:16077 dual specificity phosphatase 22 Q9NRW4 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11733513,11346645,11346645 cytoplasm 25 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms DUSP23 HGNC:21480 dual specificity phosphatase 23 Q9BVJ7 Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829) 15201283,15281913,15201283,15201283 cytoplasm 17 0 cytoplasm. nucleus multiple Theria Cell.Organisms Cell.Organisms DUSP26 HGNC:28161 dual specificity phosphatase 26 (putative) Q9BV47 Cytoplasm. Nucleus. Golgi apparatus. cytoplasm 50 1 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Eukaryota Cell.Organisms DUSP27 HGNC:25034 dual specificity phosphatase 27 (putative) Q5VZP5 cytoplasm 33 1 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota DUSP28 HGNC:33237 dual specificity phosphatase 28 Q4G0W2 cytoplasm 21 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms DUSP3 HGNC:3069 dual specificity phosphatase 3 P51452 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10224087,10224087 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms DUSP4 HGNC:3070 dual specificity phosphatase 4 Q13115 Nucleus. Nucleus (GO:0005634) 7535768 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms DUSP5 HGNC:3071 dual specificity phosphatase 5 Q16690 Nucleus (Potential). Nucleus (GO:0005634) 7836374 nucleus 36 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms DUSP6 HGNC:3072 dual specificity phosphatase 6 Q16828 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8670865,15269220,12840032,15269220 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms DUSP7 HGNC:3073 dual specificity phosphatase 7 Q16829 Cytoplasm. Cytoplasm (GO:0005737) 9788880 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms DUSP8 HGNC:3074 dual specificity phosphatase 8 Q13202 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms DUSP9 HGNC:3076 dual specificity phosphatase 9 Q99956 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9030581,9030581 cytoplasm 100 1 cytoplasm. nucleus multiple Theria Tetrapoda NA DUT HGNC:3078 deoxyuridine triphosphatase P33316 Isoform 2: Nucleus. Isoform 3: Mitochondrion. Mitochondrion (GO:0005739);Nucleus (GO:0005634);Cytoplasm (GO:0005737) 9228092,12799180/12799180,9228092,8631816/10910061,17081983 mitochondrion 34 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms DUX4 HGNC:3082 double homeobox 4 Q9UBX2 Nucleus. Note=Actively transported through the nuclear pore complex (NPC). Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus NA NA NA DUX4L2 HGNC:37267 double homeobox 4 like 2 P0CJ85 Nucleus (By similarity). nucleus 100 0 nucleus nucleus NA NA NA DUX4L4 HGNC:38686 double homeobox 4 like 4 P0CJ87 Nucleus (By similarity). nucleus 96 0 nucleus nucleus NA NA NA DUX4L5 HGNC:38689 double homeobox 4 like 5 P0CJ88 Nucleus (By similarity). nucleus 100 0 nucleus nucleus NA NA NA DUX4L6 HGNC:37265 double homeobox 4 like 6 P0CJ89 Nucleus (By similarity). nucleus 100 0 nucleus nucleus NA NA NA DUX4L7 HGNC:37266 double homeobox 4 like 7 P0CJ90 Nucleus (By similarity). nucleus 100 0 nucleus nucleus NA NA NA DUXA HGNC:32179 double homeobox A A6NLW8 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus NA NA Eukaryota DVL1 HGNC:3084 dishevelled segment polarity protein 1 O14640 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with frizzled family members (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11803455,8856345 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa DVL2 HGNC:3086 dishevelled segment polarity protein 2 O14641 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Cytoplasm (GO:0005737) 9192851 cytoplasm 33 0 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta DVL3 HGNC:3087 dishevelled segment polarity protein 3 Q92997 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 9192851 cytoplasm 34 0 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta DXO HGNC:2992 decapping exoribonuclease O77932 Nucleus. nucleus 100 0 nucleus nucleus Theria Eukaryota NA DYDC1 HGNC:23460 DPY30 domain containing 1 Q8WWB3 nucleus 20 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota DYDC2 HGNC:23468 DPY30 domain containing 2 Q96IM9 cytoplasm 51 0 cytoplasm cytoplasm Eutheria Eukaryota Eukaryota DYM HGNC:21317 dymeclin Q7RTS9 Cytoplasm. Golgi apparatus. Note=Sequence analysis programs clearly predict 1 transmembrane region. However, PubMed:18996921 shows that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol. secreted 35 5 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota DYNAP HGNC:26808 dynactin associated protein Q8N1N2 Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner. secreted 44 1 golgi apparatus membrane. plasma membrane multiple Catarrhini Opisthokonta Mammalia DYNC1H1 HGNC:2961 dynein, cytoplasmic 1, heavy chain 1 Q14204 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Lysosome (GO:0005764); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Nucleolus (GO:0005730) 14632200,11112706,11112706,11112706,11112706,15598749,11112706,11112706,17081983,15635413 cytoplasm 100 0 cytoplasm. endosome. golgi apparatus. lysosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota DYNC1I1 HGNC:2963 dynein, cytoplasmic 1, intermediate chain 1 O14576 Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Nucleus (GO:0005634) 10049579,17139249,17081983,17139249,17081983 cytoplasm 70 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms DYNC1I2 HGNC:2964 dynein, cytoplasmic 1, intermediate chain 2 Q13409 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) cytoplasm 96 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms DYNC1LI1 HGNC:18745 dynein, cytoplasmic 1, light intermediate chain 1 Q9Y6G9 Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Endosome (GO:0005768) 11243854,10893222,11243854,11243854 cytoplasm 9 0 cytoplasm. endosome. nucleus multiple Bilateria Eukaryota Eukaryota DYNC1LI2 HGNC:2966 dynein, cytoplasmic 1, light intermediate chain 2 O43237 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Microtubule (GO:0005874) 7738094,15561729 cytoplasm 12 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DYNC2H1 HGNC:2962 dynein, cytoplasmic 2, heavy chain 1 Q8NCM8 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm (By similarity). Note=Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 8666668,8832411 cytoplasm 11 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota DYNC2LI1 HGNC:24595 dynein, cytoplasmic 2, light intermediate chain 1 Q8TCX1 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm (By similarity). Note=Localizes to the apical cytoplasm (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11907264,11907264 cytoplasm 85 0 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota DYNLL1 HGNC:15476 dynein, light chain, LC8-type 1 P63167 Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Perinuclear region (GO:0048471); Microtubule (GO:0005874) 9372968,8628263,9372968,16946704,9372968,15561729 cytoplasm 93 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota DYNLL2 HGNC:24596 dynein, light chain, LC8-type 2 Q96FJ2 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) 12097491 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota NA DYNLRB1 HGNC:15468 dynein, light chain, roadblock-type 1 Q9NP97 Cytoplasm, cytoskeleton. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DYNLRB2 HGNC:15467 dynein, light chain, roadblock-type 2 Q8TF09 Cytoplasm, cytoskeleton. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota DYNLT1 HGNC:11697 dynein, light chain, Tctex-type 1 P63172 Golgi apparatus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Localizes to mitotic spindles (By similarity). Cytoplasm (GO:0005737); Cytosol (GO:0005829) 15503857,14985359 secreted 46 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota DYNLT3 HGNC:11694 dynein, light chain, Tctex-type 3 P51808 Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase. secreted 28 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota DYRK1A HGNC:3091 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Q13627 Nucleus speckle. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12799418/15126119,9748265,12576186,15126119,9748265,10329007,12576186,12964950,15068246,9070862,8975710,12799418,8769099 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DYRK1B HGNC:3092 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Q9Y463 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9918863,9918863 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms DYRK2 HGNC:3093 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 Q92630 Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9748265,9748265 nucleus 56 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms DYRK3 HGNC:3094 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 O43781 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9748265,10779429 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA DYRK4 HGNC:3095 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 Q9NR20 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms DYSF HGNC:3097 dysferlin O75923 Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein (By similarity). Note=Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca(2+)-dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncytiotrophoblast. Reaches the plasmma membrane through a caveolin-independent mechanism. Retained by caveolin at the plasmma membrane (By similarity). Colocalizes, during muscle differentiation, with CACNA1S in the T-tubule system of myotubules (By similarity). Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites (By similarity). Plasma membrane (GO:0005886) 10196375 plasma membrane 28 1 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota DYTN HGNC:23279 dystrotelin A2CJ06 Cell membrane (By similarity). cytoplasm 19 0 cytoplasm cytoplasm NA NA Opisthokonta DYX1C1 HGNC:21493 dyslexia susceptibility 1 candidate 1 Q8WXU2 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12954984,12954984 mitochondrion membrane 22 0 cytoplasm. nucleus multiple NA NA Eukaryota DZANK1 HGNC:15858 double zinc ribbon and ankyrin repeat domains 1 Q9NVP4 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms DZIP1 HGNC:20908 DAZ interacting zinc finger protein 1 Q86YF9 Nucleus. Cytoplasm. Note=In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia. Colocalizes with DAZ and DAZL in primordial germ cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15081113,15081113 nucleus 16 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota DZIP1L HGNC:26551 DAZ interacting zinc finger protein 1-like Q8IYY4 cytoplasm 24 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota DZIP3 HGNC:30938 DAZ interacting zinc finger protein 3 Q86Y13 Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 12538761,12538761 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Theria Theria Eukaryota E2F1 HGNC:3113 E2F transcription factor 1 Q01094 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11151061,11032021,17081983,10725332 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota E2F2 HGNC:3114 E2F transcription factor 2 Q14209 Nucleus. Nucleus (GO:0005634) 9688145,9144196 nucleus 100 0 nucleus nucleus Mammalia Eukaryota Eukaryota E2F3 HGNC:3115 E2F transcription factor 3 O00716 Nucleus. Nucleus (GO:0005634) 9688145,9144196,10779352 nucleus 100 2 nucleus nucleus Euteleostomi Eukaryota Eukaryota E2F4 HGNC:3118 E2F transcription factor 4, p107/p130-binding Q16254 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 9144196,9271426,11158323,10867026,11573202 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota E2F5 HGNC:3119 E2F transcription factor 5, p130-binding Q15329 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9144196,9144196 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota E2F6 HGNC:3120 E2F transcription factor 6 O75461 Nucleus. Nucleus (GO:0005634) ,9704927,12909625,16565076, nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota E2F7 HGNC:23820 E2F transcription factor 7 Q96AV8 Nucleus. Nucleus (GO:0005634) 12893818 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota E2F8 HGNC:24727 E2F transcription factor 8 A0AVK6 Nucleus. Nucleus (GO:0005634) 15722552,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota E4F1 HGNC:3121 E4F transcription factor 1 Q66K89 Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis (By similarity). Nucleus (GO:0005634) none,17081983 nucleus 32 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota EAF1 HGNC:20907 ELL associated factor 1 Q96JC9 Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with ELL to nuclear speckles. Also localized to Cajal (coiled) bodies. Nucleus (GO:0005634) 11418481,17395368,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota EAF2 HGNC:23115 ELL associated factor 2 Q96CJ1 Nucleus speckle. Note=Colocalizes with ELL to nuclear speckles. Nucleus (GO:0005634) 12446457,17395368 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota EAPP HGNC:19312 E2F-associated phosphoprotein Q56P03 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 93 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota EARS2 HGNC:29419 glutamyl-tRNA synthetase 2, mitochondrial Q5JPH6 Mitochondrion matrix (By similarity). mitochondrion 23 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms EBAG9 HGNC:3123 estrogen receptor binding site associated, antigen, 9 O00559 Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 16012715,11743045,12054692,10426319,12672804,12672804 golgi apparatus membrane 100 0 cytoplasm. golgi apparatus. golgi apparatus membrane. secreted multiple Euteleostomi Bilateria Eumetazoa EBF1 HGNC:3126 early B-cell factor 1 Q9UH73 Nucleus (Potential). Nucleus (GO:0005634) 8497258 nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta EBF2 HGNC:19090 early B-cell factor 2 Q9HAK2 Nucleus (Potential). Nucleus (GO:0005634) nucleus 74 0 nucleus nucleus NA NA Opisthokonta EBF3 HGNC:19087 early B-cell factor 3 Q9H4W6 Nucleus (Potential). nucleus 87 0 nucleus nucleus Bilateria Bilateria Opisthokonta EBF4 HGNC:29278 early B-cell factor 4 Q9BQW3 Nucleus (Potential). Nucleus (GO:0005634) nucleus 69 0 nucleus nucleus Bilateria Bilateria Opisthokonta EBI3 HGNC:3129 Epstein-Barr virus induced 3 Q14213 Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8551575,8551575 secreted 100 0 secreted secreted Theria Euteleostomi Craniata EBLN1 HGNC:39430 endogenous Bornavirus-like nucleoprotein 1 P0CF75 cytoplasm 30 2 cytoplasm cytoplasm NA NA NA EBLN2 HGNC:25493 endogenous Bornavirus-like nucleoprotein 2 Q6P2I7 nucleus 6 0 nucleus nucleus NA NA Primates EBNA1BP2 HGNC:15531 EBNA1 binding protein 2 Q99848 Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) 10074103,12768013,11438656,11327720,11790298,15561729,17081983 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota EBP HGNC:3133 emopamil binding protein (sterol isomerase) Q15125 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 7706302,7706302 endoplasmic reticulum membrane 100 5 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Mammalia Eukaryota NA EBPL HGNC:18061 emopamil binding protein-like Q9BY08 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 12760743,12760743 endoplasmic reticulum membrane 100 5 endoplasmic reticulum. endoplasmic reticulum membrane multiple Human Eukaryota Eukaryota ECD HGNC:17029 ecdysoneless homolog (Drosophila) O95905 Cytoplasm. Nucleus. cytoplasm 20 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota ECE1 HGNC:3146 endothelin converting enzyme 1 P42892 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9396733,9396733,17081983,17081983 plasma membrane 100 1 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms ECE2 HGNC:13275 endothelin converting enzyme 2 O60344 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Cytoplasmic granule membrane; Single-pass type II membrane protein (By similarity). plasma membrane 55 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms ECEL1 HGNC:3147 endothelin converting enzyme-like 1 O95672 Membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 9931490,14992683,14992683 plasma membrane 24 1 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms ECH1 HGNC:3149 enoyl CoA hydratase 1, peroxisomal Q13011 Mitochondrion (By similarity). Peroxisome (By similarity). Peroxisome (GO:0005777); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 14500732,7558027,15598749,17081983 mitochondrion 13 0 cytoplasm. mitochondrion. peroxisome multiple Eutheria Cell.Organisms Cell.Organisms ECHDC1 HGNC:21489 enoyl CoA hydratase domain containing 1 Q9NTX5 Cytoplasm, cytosol (By similarity). mitochondrion 10 0 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms ECHDC2 HGNC:23408 enoyl CoA hydratase domain containing 2 Q86YB7 Mitochondrion (Potential). mitochondrion 43 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ECHDC3 HGNC:23489 enoyl CoA hydratase domain containing 3 Q96DC8 Mitochondrion (Potential). mitochondrion 16 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms ECHS1 HGNC:3151 enoyl CoA hydratase, short chain, 1, mitochondrial P30084 Mitochondrion matrix. Mitochondrion (GO:0005739) 8012501,7669045 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms ECI1 HGNC:2703 enoyl-CoA delta isomerase 1 P42126 Mitochondrion matrix. Mitochondrion (GO:0005739) 7829074,15033988 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms ECI2 HGNC:14601 enoyl-CoA delta isomerase 2 O75521 Isoform 1: Mitochondrion (By similarity). Isoform 2: Peroxisome matrix. Peroxisome (GO:0005777) 10419495 nucleus 24 0 peroxisome peroxisome Bilateria Cell.Organisms Cell.Organisms ECM1 HGNC:3153 extracellular matrix protein 1 Q16610 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 10733679 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi ECM2 HGNC:3154 extracellular matrix protein 2, female organ and adipocyte specific O94769 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 9345023 secreted 100 0 secreted secreted Chordata Eukaryota Cell.Organisms ECSCR HGNC:35454 endothelial cell surface expressed chemotaxis and apoptosis regulator Q19T08 Cell membrane; Single-pass type I membrane protein (Potential). plasma membrane 56 1 plasma membrane plasma membrane NA NA Boreoeutheria ECSIT HGNC:29548 ECSIT signalling integrator Q9BQ95 Cytoplasm. Nucleus. Mitochondrion. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 14633973,14633973,16582907 nucleus 43 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Holozoa ECT2 HGNC:3155 epithelial cell transforming 2 Q9H8V3 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Note=Sequestered within the nucleus during interphase. Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of numerous carcinoma cells. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Membrane fraction (GO:0005624) 10579713,10579713,10579713 cytoplasm 10 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ECT2L HGNC:21118 epithelial cell transforming 2 like Q008S8 nucleus 31 0 nucleus nucleus Mammalia Deuterostomia Eukaryota EDA HGNC:3157 ectodysplasin A Q92838 Cell membrane; Single-pass type II membrane protein. Ectodysplasin-A, secreted form: Secreted. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783);Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10484778,10484778/9736768,10484778,9736768,10484778 secreted 54 1 endoplasmic reticulum. plasma membrane. secreted multiple Theria Theria Eumetazoa EDA2R HGNC:17756 ectodysplasin A2 receptor Q9HAV5 Membrane; Single-pass type III membrane protein. Plasma membrane (GO:0005886) 11039935 secreted 18 1 plasma membrane plasma membrane Euarchontoglires Amniota Eumetazoa EDAR HGNC:2895 ectodysplasin A receptor Q9UNE0 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 11570810 secreted 40 1 plasma membrane plasma membrane Chordata Chordata Olfactores EDARADD HGNC:14341 EDAR-associated death domain Q8WWZ3 Cytoplasm (Probable). Cytoplasm (GO:0005737) 11997580 nucleus 58 0 cytoplasm cytoplasm Theria Euteleostomi Chordata EDC3 HGNC:26114 enhancer of mRNA decapping 3 Q96F86 Cytoplasm, P-body. Note=Processing bodies (PB). Cytoplasm (GO:0005737) 16364915 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Opisthokonta EDC4 HGNC:17157 enhancer of mRNA decapping 4 Q6P2E9 Cytoplasm, P-body. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7520377,9067524 secreted 21 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota EDDM3A HGNC:16978 epididymal protein 3A Q14507 Secreted (Potential). Extracellular (GO:0005576) 7514008 secreted 91 0 secreted secreted Theria Theria Mammalia EDDM3B HGNC:19223 epididymal protein 3B P56851 Secreted (Potential). Extracellular (GO:0005576) 7514008 secreted 90 0 secreted secreted Human Human Mammalia EDEM1 HGNC:18967 ER degradation enhancer, mannosidase alpha-like 1 Q92611 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 11375934 endoplasmic reticulum membrane 100 0 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Eukaryota Cell.Organisms EDEM2 HGNC:15877 ER degradation enhancer, mannosidase alpha-like 2 Q9BV94 Secreted. Endoplasmic reticulum lumen. endoplasmic reticulum membrane 32 0 endoplasmic reticulum. secreted multiple Bilateria Eukaryota Cell.Organisms EDEM3 HGNC:16787 ER degradation enhancer, mannosidase alpha-like 3 Q9BZQ6 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) endoplasmic reticulum 93 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms EDF1 HGNC:3164 endothelial differentiation-related factor 1 O60869 Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10816571,10816571/10567391,10567391/10567391,10567391 nucleus 45 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms EDIL3 HGNC:3173 EGF-like repeats and discoidin I-like domains 3 O43854 Secreted. Extracellular (GO:0005576) 9420328 secreted 100 0 secreted secreted Euteleostomi Eukaryota Eukaryota EDN1 HGNC:3176 endothelin 1 P05305 Secreted. Extracellular (GO:0005576) 14769714,14735061,14685288 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Craniata EDN2 HGNC:3177 endothelin 2 P20800 Secreted. Extracellular (GO:0005576) 1701397,8671207 secreted 100 0 secreted secreted Theria Euteleostomi Craniata EDN3 HGNC:3178 endothelin 3 P14138 Secreted. Extracellular (GO:0005576) 7881755 secreted 100 0 secreted secreted Human Human Euteleostomi EDNRA HGNC:3179 endothelin receptor type A P25101 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11382773 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Metazoa EDNRB HGNC:3180 endothelin receptor type B P24530 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783) 12972292,12972292,11854280 plasma membrane 100 7 endoplasmic reticulum. lysosome. plasma membrane multiple Euteleostomi Euteleostomi Metazoa EDRF1 HGNC:24640 erythroid differentiation regulatory factor 1 Q3B7T1 Nucleus (Probable). nucleus 57 1 nucleus nucleus Deuterostomia Bilateria Eukaryota EEA1 HGNC:3185 early endosome antigen 1 Q15075 Cytoplasm. Early endosome membrane; Peripheral membrane protein. Endosome (GO:0005768); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 7768953,16415858,17351151,7768953,11226253,17351151 cytoplasm 5 0 cytoplasm. endosome. nucleus multiple Euteleostomi Bilateria Eukaryota EED HGNC:3188 embryonic ectoderm development O75530 Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14759364,10581039,16751344,14759364,9765275 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms EEF1A1 HGNC:3189 eukaryotic translation elongation factor 1 alpha 1 P68104 Cytoplasm. Nucleus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Ribosome (GO:0005840) ,8743958,18459963,,8743958,15635413,15598749,15561729 cytoplasm 99 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EEF1A2 HGNC:3192 eukaryotic translation elongation factor 1 alpha 2 Q05639 Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms EEF1B2 HGNC:3208 eukaryotic translation elongation factor 1 beta 2 P24534 Cytoplasm (GO:0005737) nucleus 74 0 nucleus nucleus Eukaryota Eukaryota Eukaryota EEF1D HGNC:3211 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) P29692 Isoform 2: Nucleus. Endoplasmic reticulum (GO:0005783);Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12773547/8743958,15598749,17081983,17081983 nucleus 100 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota EEF1E1 HGNC:3212 eukaryotic translation elongation factor 1 epsilon 1 O43324 Cytoplasm. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage. Cytoplasm (GO:0005737) cytoplasm 92 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota EEF1G HGNC:3213 eukaryotic translation elongation factor 1 gamma P26641 Nucleolus (GO:0005730); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15635413,14519448,17215244,15598749 cytoplasm 20 0 cytoplasm. mitochondrion. nucleus multiple NA NA Cell.Organisms EEF2 HGNC:3214 eukaryotic translation elongation factor 2 P13639 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829); Mitochondrion (GO:0005739); Ribosome (GO:0005840); Nucleus (GO:0005634) 3693353,17081983,15635413,16263121,15598749,15561729,17081983 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EEF2K HGNC:24615 eukaryotic elongation factor-2 kinase O00418 Cytoplasm (GO:0005737) 9144159 endoplasmic reticulum membrane 16 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms EEFSEC HGNC:24614 eukaryotic elongation factor, selenocysteine-tRNA-specific P57772 Cytoplasm (Potential). Nucleus (Potential). Cytoplasm (GO:0005737) mitochondrion 15 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms EEPD1 HGNC:22223 endonuclease/exonuclease/phosphatase family domain containing 1 Q7L9B9 Nucleus (GO:0005634) cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms EFCAB1 HGNC:25678 EF-hand calcium binding domain 1 Q9HAE3 plasma membrane 10 0 n/a n/a Deuterostomia Bilateria Eukaryota EFCAB10 HGNC:34531 EF-hand calcium binding domain 10 A6NFE3 cytoplasm 24 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota EFCAB11 HGNC:20357 EF-hand calcium binding domain 11 Q9BUY7 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms EFCAB12 HGNC:28061 EF-hand calcium binding domain 12 Q6NXP0 nucleus 85 0 nucleus nucleus Theria Deuterostomia Bilateria EFCAB13 HGNC:26864 EF-hand calcium binding domain 13 Q8IY85 cytoplasm 12 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota EFCAB14 HGNC:29051 EF-hand calcium binding domain 14 O75071 golgi apparatus membrane 11 1 golgi apparatus membrane golgi apparatus membrane Theria Bilateria Bilateria EFCAB2 HGNC:28166 EF-hand calcium binding domain 2 Q5VUJ9 cytoplasm 21 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms EFCAB3 HGNC:26379 EF-hand calcium binding domain 3 Q8N7B9 cytoplasm 22 0 cytoplasm cytoplasm Amniota Amniota Cell.Organisms EFCAB4A HGNC:28703 EF-hand calcium binding domain 4A Q8N4Y2 cytoplasm 20 0 cytoplasm cytoplasm Chordata Chordata Eumetazoa EFCAB4B HGNC:28657 EF-hand calcium binding domain 4B Q9BSW2 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms EFCAB5 HGNC:24801 EF-hand calcium binding domain 5 A4FU69 cytoplasm 13 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms EFCAB6 HGNC:24204 EF-hand calcium binding domain 6 Q5THR3 Nucleus. Nucleus (GO:0005634) 12612053 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota EFCAB7 HGNC:29379 EF-hand calcium binding domain 7 A8K855 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms EFCAB8 HGNC:34532 EF-hand calcium binding domain 8 A8MWE9 cytoplasm 86 0 cytoplasm cytoplasm Homininae Eutheria Opisthokonta EFCAB9 HGNC:34530 EF-hand calcium binding domain 9 A8MZ26 cytoplasm 96 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota EFCC1 HGNC:25692 EF-hand and coiled-coil domain containing 1 Q9HA90 cytoplasm 10 0 cytoplasm cytoplasm Mammalia Tetrapoda Chordata EFEMP1 HGNC:3218 EGF containing fibulin-like extracellular matrix protein 1 Q12805 Secreted, extracellular space (By similarity). Secreted, extracellular space, extracellular matrix (By similarity). Note=Localizes to the lamina propria underneath the olfactory epithelium (By similarity). Extracellular (GO:0005576) 10601734 secreted 39 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms EFEMP2 HGNC:3219 EGF containing fibulin-like extracellular matrix protein 2 O95967 Secreted. Extracellular (GO:0005576) 10601734 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms EFHB HGNC:26330 EF-hand domain family, member B Q8N7U6 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota EFHC1 HGNC:16406 EF-hand domain (C-terminal) containing 1 Q5JVL4 cytoplasm 10 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms EFHC2 HGNC:26233 EF-hand domain (C-terminal) containing 2 Q5JST6 nucleus 31 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota EFHD1 HGNC:29556 EF-hand domain family, member D1 Q9BUP0 cytoplasm 25 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota EFHD2 HGNC:28670 EF-hand domain family, member D2 Q96C19 Membrane raft (By similarity). Note=In a mouse immature B-cell line WEHI-231 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 vacuole 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa EFNA1 HGNC:3221 ephrin-A1 P20827 Cell membrane; Lipid-anchor, GPI-anchor. Ephrin-A1, secreted form: Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 2233719,10502115,14692877 secreted 42 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Bilateria EFNA2 HGNC:3222 ephrin-A2 O43921 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Plasma membrane (GO:0005886) 9826538 secreted 70 0 secreted secreted Euteleostomi Euteleostomi Bilateria EFNA3 HGNC:3223 ephrin-A3 P52797 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 8660976 secreted 40 1 plasma membrane plasma membrane Theria Euteleostomi Bilateria EFNA4 HGNC:3224 ephrin-A4 P52798 Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 2: Secreted (Probable). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10607706,10607706 secreted 66 1 plasma membrane. secreted multiple NA NA Bilateria EFNA5 HGNC:3225 ephrin-A5 P52803 Cell membrane; Lipid-anchor, GPI-anchor. Membrane, caveola; Lipid-anchor, GPI-anchor. Note=Compartmentalized in discrete caveolae-like membrane microdomains. Plasma membrane (GO:0005886) 10601038,9245480 secreted 17 1 plasma membrane plasma membrane Chordata Chordata Bilateria EFNB1 HGNC:3226 ephrin-B1 P98172 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9267020,10197531 plasma membrane 56 1 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa EFNB2 HGNC:3227 ephrin-B2 P52799 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12051776 plasma membrane 65 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa EFNB3 HGNC:3228 ephrin-B3 Q15768 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9126477 plasma membrane 51 1 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa EFR3A HGNC:28970 EFR3 homolog A (S. cerevisiae) Q14156 Cell membrane (By similarity). Note=Localizes to plasma membrane (By similarity). nucleus 64 0 nucleus nucleus Bilateria Eukaryota Eukaryota EFR3B HGNC:29155 EFR3 homolog B (S. cerevisiae) Q9Y2G0 nucleus 65 0 nucleus nucleus Bilateria Eukaryota Eukaryota EFS HGNC:16898 embryonal Fyn-associated substrate O43281 Cytoplasm (GO:0005737) 9349509 peroxisome membrane 38 0 cytoplasm cytoplasm Theria Euteleostomi Opisthokonta EFTUD1 HGNC:25789 elongation factor Tu GTP binding domain containing 1 Q7Z2Z2 cytoplasm 34 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms EFTUD2 HGNC:30858 elongation factor Tu GTP binding domain containing 2 Q15029 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 9233818,17081983,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EGF HGNC:3229 epidermal growth factor P01133 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 3491360,1639032,7640657 nucleus 22 1 nucleus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms EGFL6 HGNC:3235 EGF-like-domain, multiple 6 Q8IUX8 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Extracellular (GO:0005576) 10610727 secreted 30 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms EGFL7 HGNC:20594 EGF-like-domain, multiple 7 Q9UHF1 Secreted (By similarity). Extracellular (GO:0005576) 15085134 secreted 73 0 secreted secreted Euteleostomi Bilateria Eukaryota EGFL8 HGNC:13944 EGF-like-domain, multiple 8 Q99944 Secreted (Potential). secreted 34 0 secreted secreted NA NA NA EGFLAM HGNC:26810 EGF-like, fibronectin type III and laminin G domains Q63HQ2 Secreted, extracellular space, extracellular matrix (By similarity). Cell junction, synapse (By similarity). Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals (By similarity). Integral to membrane (GO:0016021) secreted 86 0 secreted secreted Bilateria Bilateria Cell.Organisms EGFR HGNC:3236 epidermal growth factor receptor P00533 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Isoform 2: Secreted. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Endosome (GO:0005768); Clathrin-coated vesicle (GO:0030136); Cytoplasm (GO:0005737) 17081983,17081983/7640657,12930839,10788520,15026342,8729040,15225635,16263120,10734107,12930839,12897150,10788520,12930839,15026342,8729040 plasma membrane 23 1 cytoplasm. endoplasmic reticulum membrane. endosome. golgi apparatus membrane. nucleus. nucleus membrane. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms EGLN1 HGNC:1232 egl-9 family hypoxia-inducible factor 1 Q9GZT9 Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm. Nuclear export requires functional XPO1. Cytoplasm (GO:0005737) 12615973 nucleus 59 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms EGLN2 HGNC:14660 egl-9 family hypoxia-inducible factor 2 Q96KS0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12615973,12615973 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi NA EGLN3 HGNC:14661 egl-9 family hypoxia-inducible factor 3 Q9H6Z9 Nucleus. Cytoplasm. Note=Colocalizes with WDR83 in the cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12615973,12615973 nucleus 53 0 cytoplasm. nucleus multiple Tetrapoda Cell.Organisms Cell.Organisms EGR1 HGNC:3238 early growth response 1 P18146 Nucleus. Nucleus (GO:0005634) 11124866 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota EGR2 HGNC:3239 early growth response 2 P11161 Nucleus. Nucleus (GO:0005634) 2496302 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota EGR3 HGNC:3240 early growth response 3 Q06889 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Mammalia Euteleostomi Eukaryota EGR4 HGNC:3241 early growth response 4 Q05215 Nucleus (Probable). Nucleus (GO:0005634) 1658795 nucleus 84 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota EHBP1 HGNC:29144 EH domain binding protein 1 Q8NDI1 Cytoplasm. Membrane. Note=Mostly found in cytosol and plasma membrane. cytoplasm 18 0 cytoplasm cytoplasm Chordata Chordata Eukaryota EHBP1L1 HGNC:30682 EH domain binding protein 1-like 1 Q8N3D4 cytoplasm 26 0 cytoplasm cytoplasm Theria Bilateria Eukaryota EHD1 HGNC:3242 EH-domain containing 1 Q9H4M9 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Associated with intracellular tubulovesicular structures. Colocalizes with FER1L5 at plasma membrane in myoblasts and mytotubes (By similarity). Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737) 15020713,12032069,15020713,17081983 cytoplasm 24 0 cytoplasm. endosome multiple Eukaryota Eukaryota Cell.Organisms EHD2 HGNC:3243 EH-domain containing 2 Q9NZN4 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein (By similarity). Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F- actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and mytotubes (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10673336,17081983,14676205,17081983,14676205 cytoplasm 23 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms EHD3 HGNC:3244 EH-domain containing 3 Q9NZN3 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cytoplasm (By similarity). Cytoplasmic vesicle (GO:0016023); Nucleus (GO:0005634) 12121420,10673336,12121420 cytoplasm 23 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms EHD4 HGNC:3245 EH-domain containing 4 Q9H223 Cell membrane (By similarity). Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11533061,17081983 cytoplasm 26 0 cytoplasm. secreted multiple Eukaryota Eukaryota Cell.Organisms EHF HGNC:3246 ets homologous factor Q9NZC4 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa EHHADH HGNC:3247 enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase Q08426 Peroxisome. Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 8188243,15561729,15598749 peroxisome 100 0 mitochondrion. peroxisome multiple Deuterostomia Cell.Organisms Cell.Organisms EHMT1 HGNC:24650 euchromatic histone-lysine N-methyltransferase 1 Q9H9B1 Nucleus. Chromosome. Note=Associates with euchromatic regions. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms EHMT2 HGNC:14129 euchromatic histone-lysine N-methyltransferase 2 Q96KQ7 Nucleus. Chromosome. Note=Associates with euchromatic regions. Does not associate with heterochromatin. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11316813,11707778,11707778 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria NA EI24 HGNC:13276 etoposide induced 2.4 O14681 Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) ,17081983 endoplasmic reticulum membrane 35 6 cytoplasm. nucleus membrane multiple Bilateria Eukaryota Eukaryota EID1 HGNC:1191 EP300 interacting inhibitor of differentiation 1 Q9Y6B2 Nucleus. Cytoplasm. Note=May shuttle between nucleus and cytoplasm. nucleus 29 0 cytoplasm. nucleus multiple NA NA Boreoeutheria EID2 HGNC:28292 EP300 interacting inhibitor of differentiation 2 Q8N6I1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14585496,12586827,12586827 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Eutheria EID2B HGNC:26796 EP300 interacting inhibitor of differentiation 2B Q96D98 Nucleus. Nucleus (GO:0005634) 15970276 nucleus 100 0 nucleus nucleus Homininae Euarchontoglires Euarchontoglires EID3 HGNC:32961 EP300 interacting inhibitor of differentiation 3 Q8N140 Nucleus. Cytoplasm. Chromosome, telomere (Probable). Note=May shuttle between nucleus and cytoplasm. nucleus 43 1 cytoplasm. nucleus multiple NA NA Eukaryota EIF1 HGNC:3249 eukaryotic translation initiation factor 1 P41567 Cytoplasm (GO:0005737) 10208429 nucleus 40 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF1AD HGNC:28147 eukaryotic translation initiation factor 1A domain containing Q8N9N8 Nucleus. nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota EIF1AX HGNC:3250 eukaryotic translation initiation factor 1A, X-linked P47813 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11447110,11447110 nucleus 14 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EIF1AY HGNC:3252 eukaryotic translation initiation factor 1A, Y-linked O14602 nucleus 14 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms EIF1B HGNC:30792 eukaryotic translation initiation factor 1B O60739 Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Eukaryota Eukaryota Eukaryota EIF2A HGNC:3254 eukaryotic translation initiation factor 2A, 65kDa Q9BY44 Cytoplasm (GO:0005737) cytoplasm 4 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF2AK1 HGNC:24921 eukaryotic translation initiation factor 2-alpha kinase 1 Q9BQI3 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 17081983 cytoplasm 78 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms EIF2AK2 HGNC:9437 eukaryotic translation initiation factor 2-alpha kinase 2 P19525 Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. Ribosome (GO:0005840); Nucleus (GO:0005634); Nucleolus (GO:0005730) 1373553,11921349,15561729,15635413 cytoplasm 14 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms EIF2AK3 HGNC:3255 eukaryotic translation initiation factor 2-alpha kinase 3 Q9NZJ5 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783) 11907036 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Bilateria Cell.Organisms EIF2AK4 HGNC:19687 eukaryotic translation initiation factor 2 alpha kinase 4 Q9P2K8 Cytoplasm (GO:0005737) 17081983 cytoplasm 16 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms EIF2B1 HGNC:3257 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa Q14232 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9235896,9235896 mitochondrion 17 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms EIF2B2 HGNC:3258 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa P49770 Cytoplasm (GO:0005737) 8887689 cytoplasm 19 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms EIF2B3 HGNC:3259 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa Q9NR50 Cytoplasm (GO:0005737) cytoplasm 20 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms EIF2B4 HGNC:3260 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa Q9UI10 Cytoplasm (GO:0005737); Cytosol (GO:0005829) ,15561729 cytoplasm 53 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms EIF2B5 HGNC:3261 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa Q13144 Cytoplasm (GO:0005737); Cytosol (GO:0005829) ,15561729 cytoplasm 8 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms EIF2D HGNC:6583 eukaryotic translation initiation factor 2D P41214 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota NA EIF2S1 HGNC:3265 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa P05198 Cytoplasmic granule (By similarity). Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 2948954,1748310,15635413,15598749 cytoplasm 99 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EIF2S2 HGNC:3266 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa P20042 Cytoplasm (GO:0005737); Nucleolus (GO:0005730) ,15635413 nucleus 14 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms EIF2S3 HGNC:3267 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa P41091 Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 8106381,15635413 mitochondrion 10 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EIF3A HGNC:3271 eukaryotic translation initiation factor 3, subunit A Q14152 Cytoplasm. Cytoplasm (GO:0005737) 9150439 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF3B HGNC:3280 eukaryotic translation initiation factor 3, subunit B P55884 Cytoplasm (By similarity). Ribosome (GO:0005840); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8995409,17081983,17081983 cytoplasm 30 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EIF3C HGNC:3279 eukaryotic translation initiation factor 3, subunit C Q99613 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Ribosome (GO:0005840) , cytoplasm 15 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF3CL HGNC:26347 eukaryotic translation initiation factor 3, subunit C-like B5ME19 Cytoplasm (By similarity). cytoplasm 18 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF3D HGNC:3278 eukaryotic translation initiation factor 3, subunit D O15371 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 31 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF3E HGNC:3277 eukaryotic translation initiation factor 3, subunit E P60228 Cytoplasm. Nucleus, PML body. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17324924,17324924 cytoplasm 32 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EIF3F HGNC:3275 eukaryotic translation initiation factor 3, subunit F O00303 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12446680,12446680 nucleus 44 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EIF3G HGNC:3274 eukaryotic translation initiation factor 3, subunit G O75821 Cytoplasm (By similarity). Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region. Cytoplasm (GO:0005737) nucleus 28 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms EIF3H HGNC:3273 eukaryotic translation initiation factor 3, subunit H O15372 Cytoplasm (By similarity). Ribosome (GO:0005840); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 14519125,,16263121 cytoplasm 16 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota EIF3I HGNC:3272 eukaryotic translation initiation factor 3, subunit I Q13347 Cytoplasm (By similarity). Ribosome (GO:0005840) 8995409 cytoplasm 5 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms EIF3J HGNC:3270 eukaryotic translation initiation factor 3, subunit J O75822 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11560931 cytoplasm 10 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota EIF3K HGNC:24656 eukaryotic translation initiation factor 3, subunit K Q9UBQ5 Nucleus. Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15327989,17081983,15327989,17081983 nucleus 23 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EIF3L HGNC:18138 eukaryotic translation initiation factor 3, subunit L Q9Y262 Cytoplasm (By similarity). Cytoplasm (GO:0005737) nucleus 34 1 nucleus nucleus Eukaryota Eukaryota Eukaryota EIF3M HGNC:24460 eukaryotic translation initiation factor 3, subunit M Q7L2H7 Cytoplasm (By similarity). cytoplasm 6 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF4A1 HGNC:3282 eukaryotic translation initiation factor 4A1 P60842 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Ribosome (GO:0005840) 12426392,12426392,15561729 cytoplasm 67 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms EIF4A2 HGNC:3284 eukaryotic translation initiation factor 4A2 Q14240 Cytoplasm (GO:0005737) cytoplasm 67 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms EIF4A3 HGNC:18683 eukaryotic translation initiation factor 4A3 P38919 Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 10623621,17081983,15635413 cytoplasm 61 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms EIF4B HGNC:3285 eukaryotic translation initiation factor 4B P23588 Cytoplasm (GO:0005737); Ribosome (GO:0005840) 6722878,6722878 cytoplasm 27 0 cytoplasm cytoplasm Deuterostomia Bilateria Opisthokonta EIF4E HGNC:3287 eukaryotic translation initiation factor 4E P06730 Cytoplasm, P-body. Perinuclear region (GO:0048471); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16467844,10648556,16467844,10648556,16467844 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EIF4E1B HGNC:33179 eukaryotic translation initiation factor 4E family member 1B A6NMX2 Cytoplasm (GO:0005737) cytoplasm 68 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota EIF4E2 HGNC:3293 eukaryotic translation initiation factor 4E family member 2 O60573 Cytoplasm (GO:0005737) 9582349 cytoplasm 19 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EIF4E3 HGNC:31837 eukaryotic translation initiation factor 4E family member 3 Q8N5X7 Cytoplasm (GO:0005737) cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota EIF4EBP1 HGNC:3288 eukaryotic translation initiation factor 4E binding protein 1 Q13541 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11114166,11114166 nucleus 18 0 cytoplasm. nucleus multiple Amniota Amniota Eukaryota EIF4EBP2 HGNC:3289 eukaryotic translation initiation factor 4E binding protein 2 Q13542 nucleus 30 0 nucleus nucleus Theria Eukaryota Eukaryota EIF4EBP3 HGNC:3290 eukaryotic translation initiation factor 4E binding protein 3 O60516 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12482586,12482586 nucleus 13 0 cytoplasm. nucleus multiple NA NA Eukaryota EIF4ENIF1 HGNC:16687 eukaryotic translation initiation factor 4E nuclear import factor 1 Q9NRA8 Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription. Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16467844,10856257,16467844,10856257,16467844 cytoplasm 41 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa EIF4G1 HGNC:3296 eukaryotic translation initiation factor 4 gamma, 1 Q04637 Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 15128869,15128869/15128869,15128869,17081983/15128869 cytoplasm 21 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota EIF4G2 HGNC:3297 eukaryotic translation initiation factor 4 gamma, 2 P78344 Ribosome (GO:0005840); Cytoplasm (GO:0005737) 16932749, cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota EIF4G3 HGNC:3298 eukaryotic translation initiation factor 4 gamma, 3 O43432 Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983/none,17081983 cytoplasm 25 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota EIF4H HGNC:12741 eukaryotic translation initiation factor 4H Q15056 Cytoplasm, perinuclear region (By similarity). Cytoplasm (GO:0005737) 9516461 cytoplasm 98 0 cytoplasm cytoplasm Deuterostomia Opisthokonta NA EIF5 HGNC:3299 eukaryotic translation initiation factor 5 P55010 Cytoplasm (GO:0005737) nucleus 94 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms EIF5A HGNC:3300 eukaryotic translation initiation factor 5A P63241 Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 7578077,10381392,7578077,10381392,11790298,15598749 cytoplasm 55 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms EIF5A2 HGNC:3301 eukaryotic translation initiation factor 5A2 Q9GZV4 Cytoplasm (By similarity). Nucleus (By similarity). Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus, nuclear pore complex (By similarity). Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730) ,15635413 cytoplasm 56 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms EIF5AL1 HGNC:17419 eukaryotic translation initiation factor 5A-like 1 Q6IS14 Cytoplasm (By similarity). Nucleus (By similarity). Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus, nuclear pore complex (By similarity). Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (By similarity). cytoplasm 54 0 cytoplasm cytoplasm NA NA Cell.Organisms EIF5B HGNC:30793 eukaryotic translation initiation factor 5B O60841 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 10432305,17081983,15635413,17081983 cytoplasm 89 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EIF6 HGNC:6159 eukaryotic translation initiation factor 6 P56537 Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Chromosome (GO:0005694); Nuclear matrix (GO:0016363); Desmosome (GO:0030057); Ribosome (GO:0005840) 10085284,11790298,15635413,15122657,9374518,10085284,10085284,9374518,14654845,10085284,10085284,10085284,10085284,10085284 cytoplasm 62 0 cytoplasm. nucleus multiple NA NA Cell.Organisms ELAC1 HGNC:14197 elaC ribonuclease Z 1 Q9H777 Nucleus (Probable). mitochondrion 21 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms ELAC2 HGNC:14198 elaC ribonuclease Z 2 Q9BQ52 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12482919,17081983 mitochondrion 16 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ELANE HGNC:3309 elastase, neutrophil expressed P08246 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Zymogen granule (GO:0042588) 2164060,9124593,2681419,16278343 secreted 22 0 cytoplasm. secreted multiple Mammalia Mammalia Cell.Organisms ELAVL1 HGNC:3312 ELAV like RNA binding protein 1 Q15717 Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 15371446,12933794,12730239,14517288,12821781,14981248,10629032,11565755,17081983,12933794,12730239,14517288,14981248,10629032,11565755,17081983,15635413,15598749 nucleus 34 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms ELAVL2 HGNC:3313 ELAV like neuron-specific RNA binding protein 2 Q12926 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8907704,8907704 nucleus 32 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms ELAVL3 HGNC:3314 ELAV like neuron-specific RNA binding protein 3 Q14576 nucleus 30 0 nucleus nucleus Theria Cell.Organisms Cell.Organisms ELAVL4 HGNC:3315 ELAV like neuron-specific RNA binding protein 4 P26378 Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9065557,2166930,9065557,10348344 nucleus 32 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms ELF1 HGNC:3316 E74-like factor 1 (ets domain transcription factor) P32519 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12727645,11884456,12727645,11884456 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Metazoa ELF2 HGNC:3317 E74-like factor 2 (ets domain transcription factor) Q15723 Nucleus. Nucleus (GO:0005634) 8756667 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa ELF3 HGNC:3318 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) P78545 Cytoplasm. Nucleus. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF- 10A and MCF-12A via a transcription-dependent mechanism. Nucleus (GO:0005634) nucleus 30 0 cytoplasm. nucleus multiple Amniota Euteleostomi Metazoa ELF4 HGNC:3319 E74-like factor 4 (ets domain transcription factor) Q99607 Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12151102,12151102 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa ELF5 HGNC:3320 E74-like factor 5 (ets domain transcription factor) Q9UKW6 Nucleus (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 15655699,15655699, nucleus 35 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa ELFN1 HGNC:33154 extracellular leucine-rich repeat and fibronectin type III domain containing 1 P0C7U0 Membrane; Single-pass type I membrane protein (Potential). Cell projection, dendrite (By similarity). Note=Localizes to excitatory synapses onto somatostatin (Sst)- containing oriens-lacunosum moleculare (O-LM) interneurons (By similarity). secreted 15 1 secreted secreted NA NA Cell.Organisms ELFN2 HGNC:29396 extracellular leucine-rich repeat and fibronectin type III domain containing 2 Q5R3F8 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 18 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Eukaryota ELK1 HGNC:3321 ELK1, member of ETS oncogene family P19419 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,19013529,19013529 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa ELK3 HGNC:3325 ELK3, ETS-domain protein (SRF accessory protein 2) P41970 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7958835,10490644 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa ELK4 HGNC:3326 ELK4, ETS-domain protein (SRF accessory protein 1) P28324 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa ELL HGNC:23114 elongation factor RNA polymerase II P55199 Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies. Nucleus (GO:0005634) 10358050,12773566,17395368 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa ELL2 HGNC:17064 elongation factor, RNA polymerase II, 2 O00472 Nucleus. Nucleus (GO:0005634) 9108030 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa ELL3 HGNC:23113 elongation factor RNA polymerase II-like 3 Q9HB65 Nucleus. Nucleus (GO:0005634) 10882741 nucleus 100 0 nucleus nucleus Mammalia Mammalia Eumetazoa ELMO1 HGNC:16286 engulfment and cell motility 1 Q92556 Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11595183,11595183 cytoplasm 7 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ELMO2 HGNC:17233 engulfment and cell motility 2 Q96JJ3 Cytoplasm. Cytoplasm, cytosol. Membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12879077,12879077 cytoplasm 5 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ELMO3 HGNC:17289 engulfment and cell motility 3 Q96BJ8 Cytoplasm (By similarity). cytoplasm 4 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota ELMOD1 HGNC:25334 ELMO/CED-12 domain containing 1 Q8N336 nucleus 13 2 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ELMOD2 HGNC:28111 ELMO/CED-12 domain containing 2 Q8IZ81 mitochondrion 12 2 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota ELMOD3 HGNC:26158 ELMO/CED-12 domain containing 3 Q96FG2 nucleus 31 2 nucleus nucleus Deuterostomia Eukaryota Eukaryota ELMSAN1 HGNC:19853 ELM2 and Myb/SANT-like domain containing 1 Q6PJG2 Nucleus (By similarity). Nucleus (GO:0005634) none,17081983 nucleus 38 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa ELN HGNC:3327 elastin P15502 Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers. Extracellular (GO:0005576) 9607766 secreted 100 0 secreted secreted Euarchontoglires Eutheria NA ELOF1 HGNC:28691 elongation factor 1 homolog (S. cerevisiae) P60002 Nucleus (By similarity). nucleus 42 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ELOVL1 HGNC:14418 ELOVL fatty acid elongase 1 Q9BW60 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eukaryota ELOVL2 HGNC:14416 ELOVL fatty acid elongase 2 Q9NXB9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Eukaryota Eukaryota ELOVL3 HGNC:18047 ELOVL fatty acid elongase 3 Q9HB03 Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome (GO:0005792) 14581464,10429212 endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Mammalia Eukaryota ELOVL4 HGNC:14415 ELOVL fatty acid elongase 4 Q9GZR5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11474659 endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane. plasma membrane multiple Deuterostomia Eukaryota Eukaryota ELOVL5 HGNC:21308 ELOVL fatty acid elongase 5 Q9NYP7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane. nucleus multiple Human Eukaryota Eukaryota ELOVL6 HGNC:15829 ELOVL fatty acid elongase 6 Q9H5J4 Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome (GO:0005792) 11567032 endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota ELOVL7 HGNC:26292 ELOVL fatty acid elongase 7 A1L3X0 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Bilateria Eukaryota ELP2 HGNC:18248 elongator acetyltransferase complex subunit 2 Q6IA86 Cytoplasm. Nucleus. Nucleus (GO:0005634) 11714725 nucleus 12 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms ELP3 HGNC:20696 elongator acetyltransferase complex subunit 3 Q9H9T3 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11714725,11714725 cytoplasm 68 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ELP4 HGNC:1171 elongator acetyltransferase complex subunit 4 Q96EB1 Cytoplasm. Nucleus. Nucleus (GO:0005634) nucleus 41 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota ELP5 HGNC:30617 elongator acetyltransferase complex subunit 5 Q8TE02 Nucleus. Cytoplasm. nucleus 63 0 cytoplasm. nucleus multiple Theria Deuterostomia Euteleostomi ELP6 HGNC:25976 elongator acetyltransferase complex subunit 6 Q0PNE2 nucleus 18 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ELSPBP1 HGNC:14417 epididymal sperm binding protein 1 Q96BH3 Secreted. secreted 100 0 secreted secreted Catarrhini Mammalia Holozoa ELTD1 HGNC:20822 EGF, latrophilin and seven transmembrane domain containing 1 Q9HBW9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 11050079,11050079 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Eukaryota EMB HGNC:30465 embigin Q6PCB8 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) secreted 13 1 secreted secreted Euteleostomi Euteleostomi Bilateria EMC1 HGNC:28957 ER membrane protein complex subunit 1 Q8N766 Membrane; Single-pass type I membrane protein. Mitochondrion (GO:0005739) 15598749 endoplasmic reticulum membrane 13 1 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota EMC10 HGNC:27609 ER membrane protein complex subunit 10 Q5UCC4 Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Secreted. secreted 49 1 secreted secreted Deuterostomia Eukaryota Holozoa EMC2 HGNC:28963 ER membrane protein complex subunit 2 Q15006 Nucleus (By similarity). Cytoplasm. Nucleus (GO:0005634) 11593002 endoplasmic reticulum 9 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EMC3 HGNC:23999 ER membrane protein complex subunit 3 Q9P0I2 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 9 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota EMC4 HGNC:28032 ER membrane protein complex subunit 4 Q5J8M3 Membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 17081983 endoplasmic reticulum membrane 23 2 nucleus nucleus Opisthokonta Eukaryota Eukaryota EMC6 HGNC:28430 ER membrane protein complex subunit 6 Q9BV81 Membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 20 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Metazoa EMC7 HGNC:24301 ER membrane protein complex subunit 7 Q9NPA0 Membrane; Single-pass type I membrane protein. endoplasmic reticulum membrane 13 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota EMC8 HGNC:7864 ER membrane protein complex subunit 8 O43402 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10337626,10337626,10337626,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Eukaryota Eukaryota EMC9 HGNC:20273 ER membrane protein complex subunit 9 Q9Y3B6 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota EMCN HGNC:16041 endomucin Q9ULC0 Isoform 1: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Isoform 2: Secreted (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 38 1 plasma membrane plasma membrane Eutheria Amniota Amniota EMD HGNC:3331 emerin P50402 Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 9361031,17081983,9361031,10965799,17081983,9472006,15598749 nucleus membrane 30 1 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus. nucleus membrane. plasma membrane multiple Mammalia Mammalia NA EME1 HGNC:24965 essential meiotic structure-specific endonuclease 1 Q96AY2 Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells. Nucleolus (GO:0005730) 14617801 nucleus 100 0 nucleus nucleus Amniota Eukaryota Eukaryota EME2 HGNC:27289 essential meiotic structure-specific endonuclease subunit 2 A4GXA9 Nucleus (Probable). nucleus 25 0 nucleus nucleus Theria Amniota Opisthokonta EMG1 HGNC:16912 EMG1 N1-specific pseudouridine methyltransferase Q92979 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms NA EMID1 HGNC:18036 EMI domain containing 1 Q96A84 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12221002,12221002,12221002 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Mammalia Chordata Eumetazoa EMILIN1 HGNC:19880 elastin microfibril interfacer 1 Q9Y6C2 Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils. Extracellular (GO:0005576) 12456677 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria EMILIN2 HGNC:19881 elastin microfibril interfacer 2 Q9BXX0 Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils. Extracellular (GO:0005576) 11278945 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms EMILIN3 HGNC:16123 elastin microfibril interfacer 3 Q9NT22 Secreted, extracellular space, extracellular matrix (By similarity). secreted 23 0 secreted secreted Tetrapoda Euteleostomi Deuterostomia EML1 HGNC:3330 echinoderm microtubule associated protein like 1 O00423 Cytoplasm, cytoskeleton (Potential). Cytoplasm (GO:0005737) 9226380 nucleus 7 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms EML2 HGNC:18035 echinoderm microtubule associated protein like 2 O95834 Cytoplasm, cytoskeleton (Potential). Nucleus (GO:0005634) 11694528,10521658 nucleus 8 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms EML3 HGNC:26666 echinoderm microtubule associated protein like 3 Q32P44 Cytoplasm, cytoskeleton (Potential). nucleus 26 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms EML4 HGNC:1316 echinoderm microtubule associated protein like 4 Q9HC35 Cytoplasm, cytoskeleton (Potential). Cytoplasm (GO:0005737); Microtubule (GO:0005874) 10995578,17081983,15561729 cytoplasm 16 2 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms EML5 HGNC:18197 echinoderm microtubule associated protein like 5 Q05BV3 Cytoplasm, cytoskeleton (Potential). nucleus 7 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms EML6 HGNC:35412 echinoderm microtubule associated protein like 6 Q6ZMW3 Cytoplasm, cytoskeleton (Potential). nucleus 6 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms EMP1 HGNC:3333 epithelial membrane protein 1 P54849 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 8884260 plasma membrane 24 3 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa EMP2 HGNC:3334 epithelial membrane protein 2 P54851 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 8884260 plasma membrane 33 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa EMP3 HGNC:3335 epithelial membrane protein 3 P54852 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 3 plasma membrane plasma membrane Eutheria Chordata Craniata EMR1 HGNC:3336 egf-like module containing, mucin-like, hormone receptor-like 1 Q14246 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7601460 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms EMR2 HGNC:3337 egf-like module containing, mucin-like, hormone receptor-like 2 Q9UHX3 Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. Plasma membrane (GO:0005886) 10903844,11994511 plasma membrane 33 7 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms EMR3 HGNC:23647 egf-like module containing, mucin-like, hormone receptor-like 3 Q9BY15 EGF-like module-containing mucin-like hormone receptor-like 3: Cell membrane; Multi-pass membrane protein. EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta: Cell membrane; Multi-pass membrane protein. EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted, extracellular space. Isoform 3: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634) 11279179,11279179,17081983 plasma membrane 33 7 nucleus. plasma membrane. secreted multiple Theria Theria Eukaryota EMX1 HGNC:3340 empty spiracles homeobox 1 Q04741 Nucleus. Cytoplasm. Note=Might be shuttling between the nucleus and the cytoplasm. Nucleus (GO:0005634) 8843394,7601155 nucleus 41 0 cytoplasm. nucleus multiple Eutheria Deuterostomia Eukaryota EMX2 HGNC:3341 empty spiracles homeobox 2 Q04743 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota EN1 HGNC:3342 engrailed homeobox 1 Q05925 Nucleus. Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9169834,9169834 nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Opisthokonta EN2 HGNC:3343 engrailed homeobox 2 P19622 Nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9169834,9169834 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ENAH HGNC:18271 enabled homolog (Drosophila) Q8N8S7 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cell junction, synapse (By similarity). Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Plasma membrane (GO:0005886);Nucleus (GO:0005634) 17081983,17081983/12967995,10725224/17081983 cytoplasm 48 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota ENAM HGNC:3344 enamelin Q9NRM1 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 10831092 secreted 100 0 secreted secreted Mammalia Mammalia Amniota ENC1 HGNC:3345 ectodermal-neural cortex 1 (with BTB domain) O14682 Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9566959,11691783,10828068 nucleus 18 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms ENDOD1 HGNC:29129 endonuclease domain containing 1 O94919 Secreted (Potential). endoplasmic reticulum membrane 53 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi NA ENDOG HGNC:3346 endonuclease G Q14249 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11452314,11452314,11452314 mitochondrion 100 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms ENDOU HGNC:14369 endonuclease, polyU-specific P21128 Secreted (Potential). secreted 31 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms ENDOV HGNC:26640 endonuclease V Q8N8Q3 cytoplasm 61 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ENG HGNC:3349 endoglin P17813 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1692830 secreted 47 1 plasma membrane plasma membrane Theria Amniota Euteleostomi ENGASE HGNC:24622 endo-beta-N-acetylglucosaminidase Q8NFI3 Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737) 12114544 secreted 26 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ENHO HGNC:24838 energy homeostasis associated Q6UWT2 Secreted. secreted 100 1 secreted secreted Homininae Eutheria Eutheria ENKD1 HGNC:25246 enkurin domain containing 1 Q9H0I2 nucleus 72 0 nucleus nucleus Euteleostomi Eukaryota Metazoa ENKUR HGNC:28388 enkurin, TRPC channel interacting protein Q8TC29 Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and flagellar principal piece. nucleus 61 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ENO1 HGNC:3350 enolase 1, (alpha) P06733 Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Isoform MBP-1: Nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Extracellular (GO:0005576) 12354300,9308760,11169399,10802057,16188874 cytoplasm 92 0 cytoplasm. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms ENO2 HGNC:3353 enolase 2 (gamma, neuronal) P09104 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity). Cytoplasm (GO:0005737) 8035205 cytoplasm 89 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA ENO3 HGNC:3354 enolase 3 (beta, muscle) P13929 Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity). Extracellular (GO:0005576) 16188874 cytoplasm 100 0 cytoplasm. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms ENO4 HGNC:31670 enolase family member 4 A6NNW6 cytoplasm 12 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms ENOPH1 HGNC:24599 enolase-phosphatase 1 Q9UHY7 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 33 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms ENOSF1 HGNC:30365 enolase superfamily member 1 Q7L5Y1 Mitochondrion (Probable). cytoplasm 26 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms ENOX1 HGNC:25474 ecto-NOX disulfide-thiol exchanger 1 Q8TC92 Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated. cytoplasm 17 0 secreted secreted Euteleostomi Bilateria Eukaryota ENOX2 HGNC:2259 ecto-NOX disulfide-thiol exchanger 2 Q16206 Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11488599,8150545 cytoplasm 18 0 cytoplasm. secreted multiple Euteleostomi Bilateria Metazoa ENPEP HGNC:3355 glutamyl aminopeptidase (aminopeptidase A) Q07075 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8346219,15048132,11390025 plasma membrane 21 1 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms ENPP1 HGNC:3356 ectonucleotide pyrophosphatase/phosphodiesterase 1 P22413 Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Secreted (By similarity). Note=The proteolytically processed form is secreted (By similarity). Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side. Plasma membrane (GO:0005886) 1315502 secreted 36 1 plasma membrane plasma membrane Opisthokonta Eukaryota Cell.Organisms ENPP2 HGNC:3357 ectonucleotide pyrophosphatase/phosphodiesterase 2 Q13822 Secreted. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12176993,8798697,7982964 secreted 100 1 plasma membrane. secreted multiple Opisthokonta Eukaryota Cell.Organisms ENPP3 HGNC:3358 ectonucleotide pyrophosphatase/phosphodiesterase 3 O14638 Membrane; Single-pass type II membrane protein (Potential). Secreted. Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells. Plasma membrane (GO:0005886); Zymogen granule (GO:0042588) 14533006,16278343 secreted 34 1 plasma membrane. secreted multiple Opisthokonta Eukaryota Cell.Organisms ENPP4 HGNC:3359 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) Q9Y6X5 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) ,17081983 plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Cell.Organisms Cell.Organisms ENPP5 HGNC:13717 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) Q9UJA9 Secreted (Potential). Membrane; Single-pass membrane protein (Potential). plasma membrane 39 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms ENPP6 HGNC:23409 ectonucleotide pyrophosphatase/phosphodiesterase 6 Q6UWR7 Cell membrane; Lipid-anchor, GPI-anchor. Note=A small amount of the protein may be found in the extracellular milieu. plasma membrane 20 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms ENPP7 HGNC:23764 ectonucleotide pyrophosphatase/phosphodiesterase 7 Q6UWV6 Membrane; Single-pass type I membrane protein (Potential). Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 12885774,12671034,12671034 secreted 22 1 endosome. golgi apparatus. plasma membrane multiple Deuterostomia Cell.Organisms NA ENSA HGNC:3360 endosulfine alpha O43768 Cytoplasm (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 98 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta ENTHD1 HGNC:26352 ENTH domain containing 1 Q8IYW4 cytoplasm 48 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota ENTHD2 HGNC:26458 ENTH domain containing 2 Q96N21 Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Extensively colocalizes with AP-4 in a punctate juxtanuclear pattern, which likely corresponds to trans-Golgi network. Requires a functional AP-4 complex for recruitment to vesicle membrane. cytoplasm 100 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ENTPD1 HGNC:3363 ectonucleoside triphosphate diphosphohydrolase 1 P49961 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8955160,10471369,12832497 plasma membrane 31 2 plasma membrane. secreted multiple Euteleostomi Eukaryota Cell.Organisms ENTPD2 HGNC:3364 ectonucleoside triphosphate diphosphohydrolase 2 Q9Y5L3 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11827541,12888562 plasma membrane 32 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms ENTPD3 HGNC:3365 ectonucleoside triphosphate diphosphohydrolase 3 O75355 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 9675246,10231536,11300774 plasma membrane 31 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms ENTPD4 HGNC:14573 ectonucleoside triphosphate diphosphohydrolase 4 Q9Y227 Golgi apparatus membrane; Multi-pass membrane protein (Potential). Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein (Potential). Note=Localizes in the Golgi and autophagic vacuoles/lysosomes. Golgi apparatus (GO:0005794); Lysosome (GO:0005764) 9556635,10393803,10393803 golgi apparatus membrane 21 2 golgi apparatus. lysosome multiple Opisthokonta Eukaryota Cell.Organisms ENTPD5 HGNC:3367 ectonucleoside triphosphate diphosphohydrolase 5 O75356 Endoplasmic reticulum membrane (By similarity); Single-pass type II membrane protein (By similarity). Extracellular (GO:0005576) 10400613,11041857 endoplasmic reticulum membrane 86 1 secreted secreted Opisthokonta Eukaryota Cell.Organisms ENTPD6 HGNC:3368 ectonucleoside triphosphate diphosphohydrolase 6 (putative) O75354 Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=But also occurs in a soluble extracellular form. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11041856,14529283,11041856,14529283 endoplasmic reticulum membrane 42 1 golgi apparatus membrane. plasma membrane. secreted multiple Opisthokonta Eukaryota Cell.Organisms ENTPD7 HGNC:19745 ectonucleoside triphosphate diphosphohydrolase 7 Q9NQZ7 Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential). Note=Localizes to intracellular vesicular compartments. Lysosome (GO:0005764) 11278936 golgi apparatus membrane 23 2 lysosome lysosome Opisthokonta Eukaryota Cell.Organisms ENTPD8 HGNC:24860 ectonucleoside triphosphate diphosphohydrolase 8 Q5MY95 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 69 2 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms ENY2 HGNC:24449 enhancer of yellow 2 homolog (Drosophila) Q9NPA8 Nucleus (Probable). Nucleus (GO:0005634) 11438676 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota EOGT HGNC:28526 EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase Q5NDL2 Endoplasmic reticulum lumen (By similarity). endoplasmic reticulum 39 0 endoplasmic reticulum endoplasmic reticulum Chordata Bilateria Cell.Organisms EOMES HGNC:3372 eomesodermin O95936 Nucleus (Probable). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa EP300 HGNC:3373 E1A binding protein p300 Q09472 Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. Co-localizes with ROCK2 in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16648821,,11296295,12649209,12970734,16648821, nucleus 20 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota EP400 HGNC:11958 E1A binding protein p400 Q96L91 Nucleus (By similarity). Nucleus (GO:0005634) 11509179,17081983 nucleus 28 2 nucleus nucleus Eukaryota Eukaryota Cell.Organisms EP400NL HGNC:26602 EP400 N-terminal like Q6ZTU2 nucleus 92 0 nucleus nucleus Eukaryota Eukaryota Chordata EPAS1 HGNC:3374 endothelial PAS domain protein 1 Q99814 Nucleus (Potential). Nucleus (GO:0005634) 11313887,17324924 nucleus 19 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms EPB41 HGNC:3377 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) P11171 Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 9598318,11737230,12960380,12239178,9598318,11737230,12427749,2808371,12239178,11737230,12427749,9207085/10189366,15184364,15184364,15184364 cytoplasm 53 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota EPB41L1 HGNC:3378 erythrocyte membrane protein band 4.1-like 1 Q9H4G0 Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 12181426,10594058,10594058,12444087,12444087,10414974 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota EPB41L2 HGNC:3379 erythrocyte membrane protein band 4.1-like 2 O43491 Cytoplasm, cytoskeleton (By similarity). Cell membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12974671,9598318,12974671,15598749 cytoplasm 58 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Eukaryota EPB41L3 HGNC:3380 erythrocyte membrane protein band 4.1-like 3 Q9Y2J2 Cytoplasm, cytoskeleton (By similarity). Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of actively dividing cells. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9892180,17081983 cytoplasm 61 2 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Eukaryota EPB41L4A HGNC:13278 erythrocyte membrane protein band 4.1 like 4A Q9HCS5 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7983158,17081983 cytoplasm 27 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota EPB41L4B HGNC:19818 erythrocyte membrane protein band 4.1 like 4B Q9H329 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) 10783258 cytoplasm 28 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota EPB41L5 HGNC:19819 erythrocyte membrane protein band 4.1 like 5 Q9HCM4 Cytoplasm. Cell junction, adherens junction. Note=Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker (By similarity). cytoplasm 24 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota EPB42 HGNC:3381 erythrocyte membrane protein band 4.2 P16452 Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of erythrocyte membranes. Plasma membrane (GO:0005886) 1689063 cytoplasm 18 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota EPC1 HGNC:19876 enhancer of polycomb homolog 1 (Drosophila) Q9H2F5 Nucleus. Nucleus (GO:0005634) 10976108 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota EPC2 HGNC:24543 enhancer of polycomb homolog 2 (Drosophila) Q52LR7 Nucleus (By similarity). nucleus 46 0 nucleus nucleus Bilateria Eukaryota Eukaryota EPCAM HGNC:11529 epithelial cell adhesion molecule P16422 Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Co-localizes with CLDN7 at the lateral cell membrane and tight junction. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11058587,11058587,16188874 secreted 33 1 plasma membrane. secreted multiple Tetrapoda Euteleostomi Craniata EPDR1 HGNC:17572 ependymin related 1 Q9UM22 Secreted. Extracellular (GO:0005576) 11248421 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Holozoa EPG5 HGNC:29331 ectopic P-granules autophagy protein 5 homolog (C. elegans) Q9HCE0 cytoplasm 6 2 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta EPGN HGNC:17470 epithelial mitogen Q6UW88 Isoform 1: Membrane; Single-pass type I membrane protein (Probable). Isoform 2: Membrane; Single-pass type I membrane protein (Probable). Isoform 3: Secreted (Probable). Isoform 4: Secreted (Probable). Isoform 5: Secreted (Probable). Isoform 6: Secreted (Probable). Integral to membrane (GO:0016021) plasma membrane 22 1 secreted secreted Amniota Amniota Euteleostomi EPHA1 HGNC:3385 EPH receptor A1 P21709 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10502115,14718574 plasma membrane 100 1 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms EPHA10 HGNC:19987 EPH receptor A10 Q5JZY3 Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 3: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 2: Secreted (Probable). plasma membrane 28 1 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms EPHA2 HGNC:3386 EPH receptor A2 P29317 Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single- pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells. Plasma membrane (GO:0005886) 10502115 plasma membrane 39 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHA3 HGNC:3387 EPH receptor A3 P29320 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Soluble fraction (GO:0005625) 1737782,16186805,15355990,9685371 plasma membrane 37 1 cytoplasm. plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms EPHA4 HGNC:3388 EPH receptor A4 P54764 Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Early endosome (By similarity). Note=Clustered upon activation and targeted to early endosome (By similarity). Plasma membrane (GO:0005886) 12084815 plasma membrane 40 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHA5 HGNC:3389 EPH receptor A5 P54756 Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite. Cell projection (GO:0042995) 9321687 plasma membrane 38 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHA6 HGNC:19296 EPH receptor A6 Q9UF33 Membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 39 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHA7 HGNC:3390 EPH receptor A7 Q15375 Cell membrane (Probable); Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9707552,14718574 plasma membrane 38 1 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms EPHA8 HGNC:3391 EPH receptor A8 P29322 Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell projection (By similarity). Early endosome membrane (By similarity). Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes (By similarity). Plasma membrane (GO:0005886) 11416136 plasma membrane 35 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHB1 HGNC:3392 EPH receptor B1 P54762 Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite (By similarity). Plasma membrane (GO:0005886) 12084815 plasma membrane 47 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHB2 HGNC:3393 EPH receptor B2 P29323 Cell membrane; Single-pass type I membrane protein. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Plasma membrane (GO:0005886) 11585923 plasma membrane 46 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHB3 HGNC:3394 EPH receptor B3 P54753 Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite (By similarity). Plasma membrane (GO:0005886) 9990854 plasma membrane 51 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHB4 HGNC:3395 EPH receptor B4 P54760 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10037197 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms EPHB6 HGNC:3396 EPH receptor B6 O15197 Membrane; Single-pass type I membrane protein. Isoform 3: Secreted (Probable). Plasma membrane (GO:0005886) 11466354 plasma membrane 31 1 plasma membrane. secreted multiple Bilateria Eukaryota NA EPHX1 HGNC:3401 epoxide hydrolase 1, microsomal (xenobiotic) P07099 Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Endosome (GO:0005768) 7835893,7835893,7892276 plasma membrane 5 0 endoplasmic reticulum. endosome. nucleus multiple Bilateria Cell.Organisms Cell.Organisms EPHX2 HGNC:3402 epoxide hydrolase 2, cytoplasmic P34913 Cytoplasm. Peroxisome. Cytoplasm (GO:0005737); Peroxisome (GO:0005777) 6185139,8342951 endoplasmic reticulum membrane 16 0 cytoplasm. peroxisome multiple Deuterostomia Cell.Organisms Cell.Organisms EPHX3 HGNC:23760 epoxide hydrolase 3 Q9H6B9 Secreted (Potential). endoplasmic reticulum membrane 22 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Cell.Organisms EPHX4 HGNC:23758 epoxide hydrolase 4 Q8IUS5 Membrane; Single-pass type II membrane protein (Potential). endoplasmic reticulum membrane 23 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms EPM2A HGNC:3413 epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) B3EWF7 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Ribosome (GO:0005840) 11001928,11883934,11883934,11220751,11220751,11001928,11001928 nucleus 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Eukaryota Eukaryota EPM2AIP1 HGNC:19735 EPM2A (laforin) interacting protein 1 Q7L775 Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783) 12782127 endoplasmic reticulum 100 1 endoplasmic reticulum endoplasmic reticulum Theria Bilateria Opisthokonta EPN1 HGNC:21604 epsin 1 Q9Y6I3 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, clathrin-coated pit (By similarity). Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12353027,12353027,10791968 cytoplasm 47 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Eukaryota EPN2 HGNC:18639 epsin 2 O95208 Cytoplasm. Cytoplasmic vesicle, clathrin- coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex. Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794) 10567358,10567358 cytoplasm 100 0 cytoplasm. golgi apparatus multiple Bilateria Opisthokonta Eukaryota EPN3 HGNC:18235 epsin 3 Q9H201 Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus (Probable). Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11359770,11359770,11359770 cytoplasm 42 0 cytoplasm. nucleus. secreted multiple Mammalia Euteleostomi Eukaryota EPO HGNC:3415 erythropoietin P01588 Secreted. Extracellular (GO:0005576) 3838366 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi EPOR HGNC:3416 erythropoietin receptor P19235 Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted. Note=Secreted and located to the cell surface. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 1848667,14699131,11782306 plasma membrane 21 1 endoplasmic reticulum. plasma membrane. secreted multiple Euteleostomi Euteleostomi Euteleostomi EPPIN HGNC:15932 epididymal peptidase inhibitor O95925 Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa. Extracellular (GO:0005576); Acrosome (GO:0001669) 11404006,12206714,11404006 secreted 100 0 lysosome. secreted multiple Mammalia Bilateria Cell.Organisms EPPK1 HGNC:15577 epiplakin 1 P58107 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11278896,17081983,17081983 cytoplasm 25 0 cytoplasm. nucleus multiple NA NA NA EPRS HGNC:3418 glutamyl-prolyl-tRNA synthetase P07814 Cytoplasm (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleus (GO:0005634) 8188258,17081983,15561729,17081983 cytoplasm 48 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EPS15 HGNC:3419 epidermal growth factor receptor pathway substrate 15 P42566 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Isoform 2: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes. Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829); Coated vesicle (GO:0030135) 9049247,9049247,9182572,9049247,15465819,17081983,15465819,9182572,9182572 cytoplasm 14 0 cytoplasm. endosome. nucleus multiple Opisthokonta Cell.Organisms Eukaryota EPS15L1 HGNC:24634 epidermal growth factor receptor pathway substrate 15-like 1 Q9UBC2 Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Membrane, coated pit (By similarity). Note=Localized to plasma membrane coated pits (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11777906,10906484,17081983,11777906,17081983,9446614 cytoplasm 12 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms EPS8 HGNC:3420 epidermal growth factor receptor pathway substrate 8 Q12929 Cytoplasm, cell cortex (By similarity). Cell projection, ruffle membrane (By similarity). Cell projection, growth cone (By similarity). Cell projection, stereocilium (By similarity). Note=Localizes to the midzone of dividing cells (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11524436,17081983,11524436,11524436 cytoplasm 36 0 cytoplasm. nucleus multiple Bilateria Bilateria Opisthokonta EPS8L1 HGNC:21295 EPS8-like 1 Q8TE68 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria NA EPS8L2 HGNC:21296 EPS8-like 2 Q9H6S3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Opisthokonta EPS8L3 HGNC:21297 EPS8-like 3 Q8TE67 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota EPSTI1 HGNC:16465 epithelial stromal interaction 1 (breast) Q96J88 cytoplasm 6 0 cytoplasm cytoplasm Theria Deuterostomia Eumetazoa EPT1 HGNC:29361 ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) Q9C0D9 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 14 9 golgi apparatus membrane golgi apparatus membrane Bilateria Eukaryota Cell.Organisms EPX HGNC:3423 eosinophil peroxidase P11678 Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. Cytoplasm (GO:0005737) 10971470 secreted 42 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms EPYC HGNC:3053 epiphycan Q99645 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10330124 secreted 78 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms EQTN HGNC:1359 equatorin, sperm acrosome associated Q9NQ60 Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Single-pass type I membrane protein (By similarity). Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes (By similarity). Integral to membrane (GO:0016021) nucleus 15 1 nucleus nucleus Eutheria Eutheria Eutheria ERAL1 HGNC:3424 Era-like 12S mitochondrial rRNA chaperone 1 O75616 Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11733036,11733036 cytoplasm 32 0 endoplasmic reticulum. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ERAP1 HGNC:18173 endoplasmic reticulum aminopeptidase 1 Q9NZ08 Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12436109,11056387,15598749 endoplasmic reticulum membrane 39 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Chordata Bilateria Cell.Organisms ERAP2 HGNC:29499 endoplasmic reticulum aminopeptidase 2 Q6P179 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 12799365 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Chordata Bilateria Cell.Organisms ERAS HGNC:5174 ES cell expressed Ras Q7Z444 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasm (GO:0005737) 12774123 cytoplasm 16 0 cytoplasm cytoplasm Eutheria Eutheria NA ERBB2 HGNC:3430 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 P04626 Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Isoform 2: Cytoplasm. Nucleus. Isoform 3: Cytoplasm. Nucleus. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 3945311,10485918,12939402,17081983 cytoplasm 22 1 cytoplasm. nucleus. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms ERBB2IP HGNC:15842 erbb2 interacting protein Q96RT1 Cell junction, hemidesmosome. Nucleus membrane (By similarity). Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11375975,11279080,11375975,11375975 cytoplasm 17 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms ERBB3 HGNC:3431 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 P21860 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7685162,7685162 cytoplasm 23 1 plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms ERBB4 HGNC:3432 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 Q15303 Cell membrane; Single-pass type I membrane protein. ERBB4 intracellular domain: Nucleus. Mitochondrion. Note=Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11679632,15534001,11679632,15534001,15534001 cytoplasm 26 1 cytoplasm. mitochondrion. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms ERC1 HGNC:17072 ELKS/RAB6-interacting/CAST family member 1 Q8IUD2 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity). Note=In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11929610,12391317,11929610 cytoplasm 17 0 cytoplasm. golgi apparatus multiple Chordata Bilateria Cell.Organisms ERC2 HGNC:31922 ELKS/RAB6-interacting/CAST family member 2 O15083 Cytoplasm. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). Cytoplasm (GO:0005737) 14734538 cytoplasm 2 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota ERCC1 HGNC:3433 excision repair cross-complementation group 1 P07992 Nucleus. Nucleus (GO:0005634) 10320375 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ERCC2 HGNC:3434 excision repair cross-complementation group 2 P18074 Nucleus. Cytoplasm, cytoskeleton, spindle. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11266560,11266560,15635413 nucleus 46 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms ERCC3 HGNC:3435 excision repair cross-complementation group 3 P19447 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10403766,10403766 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ERCC4 HGNC:3436 excision repair cross-complementation group 4 Q92889 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,8197175,12571280,,17081983 nucleus 20 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms ERCC5 HGNC:3437 excision repair cross-complementation group 5 P28715 Nucleus. Nucleus (GO:0005634) 11259578,8710877,8413238 nucleus 100 0 nucleus nucleus Homininae Eukaryota Cell.Organisms ERCC6 HGNC:3438 excision repair cross-complementation group 6 Q03468 Nucleus. Nucleus (GO:0005634) 12531019 nucleus 100 0 nucleus nucleus NA NA Cell.Organisms ERCC6L HGNC:20794 excision repair cross-complementation group 6-like Q2NKX8 Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms ERCC6L2 HGNC:26922 excision repair cross-complementation group 6-like 2 Q5T890 Nucleus (Probable). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome. Nucleus (GO:0005634) nucleus 20 0 cytoplasm. nucleus multiple Amniota Eukaryota Cell.Organisms ERCC8 HGNC:3439 excision repair cross-complementation group 8 Q13216 Nucleus (Probable). Nucleus (GO:0005634) 11782547 cytoplasm 18 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms EREG HGNC:3443 epiregulin O14944 Epiregulin: Secreted, extracellular space. Proepiregulin: Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576) 9337852 plasma membrane 36 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Euteleostomi ERF HGNC:3444 Ets2 repressor factor P50548 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14729966,14729966 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa ERG HGNC:3446 v-ets avian erythroblastosis virus E26 oncogene homolog P11308 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleus (GO:0005634) 8502479 nucleus 94 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa ERGIC1 HGNC:29205 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 Q969X5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 15308636,15308636,15308636 mitochondrion membrane 10 2 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Deuterostomia Eukaryota Eukaryota ERGIC2 HGNC:30208 ERGIC and golgi 2 Q96RQ1 Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. PubMed:11445006 states that it localizes to the nucleus; PubMed:17980171 shows a partial localization in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11445006,11445006 plasma membrane 2 2 cytoplasm. endoplasmic reticulum membrane. golgi apparatus membrane. nucleus multiple Opisthokonta Opisthokonta Eukaryota ERGIC3 HGNC:15927 ERGIC and golgi 3 Q9Y282 Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi. Golgi apparatus (GO:0005794) 15308636 secreted 11 2 endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Eukaryota Eukaryota Eukaryota ERH HGNC:3447 enhancer of rudimentary homolog (Drosophila) P84090 Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 25 0 nucleus nucleus Bilateria Eukaryota Eukaryota ERI1 HGNC:23994 exoribonuclease 1 Q8IV48 Cytoplasm. Nucleus. Nucleus, nucleolus. cytoplasm 24 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms ERI2 HGNC:30541 ERI1 exoribonuclease family member 2 A8K979 nucleus 33 0 nucleus nucleus Human Eukaryota Cell.Organisms ERI3 HGNC:17276 ERI1 exoribonuclease family member 3 O43414 cytoplasm 18 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms ERICH1 HGNC:27234 glutamate-rich 1 Q86X53 nucleus 13 0 nucleus nucleus Amniota Amniota Cell.Organisms ERICH2 HGNC:44395 glutamate-rich 2 A1L162 nucleus 89 0 nucleus nucleus NA NA Metazoa ERICH3 HGNC:25346 glutamate-rich 3 Q5RHP9 nucleus 11 0 nucleus nucleus Tetrapoda Deuterostomia Holozoa ERICH4 HGNC:34497 glutamate-rich 4 A6NGS2 nucleus 60 0 nucleus nucleus Homininae Euarchontoglires NA ERICH5 HGNC:26823 glutamate-rich 5 Q6P6B1 nucleus 9 0 nucleus nucleus Theria Theria Mammalia ERICH6 HGNC:28602 glutamate-rich 6 Q7L0X2 nucleus 81 0 nucleus nucleus Amniota Eukaryota Eumetazoa ERICH6B HGNC:26523 glutamate-rich 6B Q5W0A0 nucleus 13 0 nucleus nucleus Homininae Eutheria Eumetazoa ERLEC1 HGNC:25222 endoplasmic reticulum lectin 1 Q96DZ1 Endoplasmic reticulum lumen. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota ERLIN1 HGNC:16947 ER lipid raft associated 1 O75477 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11118313,11118313 endoplasmic reticulum membrane 100 0 cytoplasm. endoplasmic reticulum membrane multiple Deuterostomia Eukaryota Cell.Organisms ERLIN2 HGNC:1356 ER lipid raft associated 2 O94905 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. endoplasmic reticulum membrane 100 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota ERMAP HGNC:15743 erythroblast membrane-associated protein (Scianna blood group) Q96PL5 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Integral to membrane (GO:0016021); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12393480,11783959,11783959 plasma membrane 28 1 cytoplasm. plasma membrane multiple Mammalia Mammalia Deuterostomia ERMARD HGNC:21056 ER membrane-associated RNA degradation Q5T6L9 Membrane; Multi-pass membrane protein (Potential). secreted 69 2 n/a n/a Amniota Eukaryota Eukaryota ERMN HGNC:29208 ermin, ERM-like protein Q8TAM6 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) 16421295 cytoplasm 54 0 cytoplasm cytoplasm Amniota Amniota Opisthokonta ERMP1 HGNC:23703 endoplasmic reticulum metallopeptidase 1 Q7Z2K6 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 83 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Cell.Organisms ERN1 HGNC:3449 endoplasmic reticulum to nucleus signaling 1 O75460 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 9637683,9637683 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Eukaryota Eukaryota Cell.Organisms ERN2 HGNC:16942 endoplasmic reticulum to nucleus signaling 2 Q76MJ5 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11175748,10619423,10619423 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Eukaryota Eukaryota Cell.Organisms ERO1L HGNC:13280 ERO1-like (S. cerevisiae) Q96HE7 Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10671517,15598749 secreted 54 0 endoplasmic reticulum. mitochondrion multiple Eukaryota Eukaryota Eukaryota ERO1LB HGNC:14355 ERO1-like beta (S. cerevisiae) Q86YB8 Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783) 10818100 nucleus 19 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota ERP27 HGNC:26495 endoplasmic reticulum protein 27 Q96DN0 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 16940051 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Amniota Euteleostomi Eukaryota ERP29 HGNC:13799 endoplasmic reticulum protein 29 P30040 Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 9738895,11897809,9492298,15598749 endoplasmic reticulum 67 0 endoplasmic reticulum. melanosome. mitochondrion multiple Tetrapoda Eukaryota Eukaryota ERP44 HGNC:18311 endoplasmic reticulum protein 44 Q9BS26 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 11847130 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms ERRFI1 HGNC:18185 ERBB receptor feedback inhibitor 1 Q9UJM3 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus (By similarity). Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). Cytoplasm (GO:0005737) 7641805 nucleus 45 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata ESAM HGNC:17474 endothelial cell adhesion molecule Q96AP7 Cell junction, adherens junction (By similarity). Cell junction, tight junction (By similarity). Cell membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 17 1 plasma membrane plasma membrane Amniota Euteleostomi Bilateria ESCO1 HGNC:24645 establishment of sister chromatid cohesion N-acetyltransferase 1 Q5FWF5 Nucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis. Nucleus (GO:0005634) 14576321 nucleus 100 0 nucleus nucleus Amniota Eukaryota Eukaryota ESCO2 HGNC:27230 establishment of sister chromatid cohesion N-acetyltransferase 2 Q56NI9 Nucleus. Chromosome. Nucleus (GO:0005634) 15821733 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota ESD HGNC:3465 esterase D P10768 Cytoplasm. Cytoplasmic vesicle. Cytoplasm (GO:0005737) 3591015 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms ESF1 HGNC:15898 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) Q9H501 Nucleus, nucleolus (By similarity). Nucleus, nucleoplasm (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,17081983,17081983 nucleus 76 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota ESM1 HGNC:3466 endothelial cell-specific molecule 1 Q9NQ30 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11025405,11025405 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Craniata ESPL1 HGNC:16856 extra spindle pole bodies homolog 1 (S. cerevisiae) Q14674 Cytoplasm. Nucleus. Centrosome (GO:0005813) 12672959 nucleus 24 6 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Eukaryota ESPN HGNC:13281 espin B1AK53 Cytoplasm, cytoskeleton (By similarity). Cell projection, stereocilium (By similarity). Cell projection, microvillus (By similarity). Actin filament (GO:0005884); Actin filament (GO:0005884); Dendrite (GO:0030425) 8799813,12598619,12598619 cytoplasm 35 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms ESPNL HGNC:27937 espin-like Q6ZVH7 cytoplasm 14 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms ESR1 HGNC:3467 estrogen receptor 1 P03372 Isoform 1: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 3: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) ,12167865,15145444,19117995,,12167865,15556606,15556606,16113100 nucleus 85 0 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Tetrapoda Euteleostomi Metazoa ESR2 HGNC:3468 estrogen receptor 2 (ER beta) Q92731 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11344243,11344243 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa ESRP1 HGNC:25966 epithelial splicing regulatory protein 1 Q6NXG1 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota ESRP2 HGNC:26152 epithelial splicing regulatory protein 2 Q9H6T0 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota ESRRA HGNC:3471 estrogen-related receptor alpha P11474 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Bilateria Metazoa ESRRB HGNC:3473 estrogen-related receptor beta O95718 Nucleus (Potential). Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa ESRRG HGNC:3474 estrogen-related receptor gamma P62508 Nucleus (Probable). Nucleus (GO:0005634) 12470660,15598686,14963109 nucleus 73 0 nucleus nucleus Euteleostomi Bilateria Metazoa ESX1 HGNC:14865 ESX homeobox 1 Q8N693 Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm. Nucleus (GO:0005634) nucleus 38 0 cytoplasm. nucleus multiple Human Eutheria NA ESYT1 HGNC:29534 extended synaptotagmin-like protein 1 Q9BSJ8 Membrane; Multi-pass membrane protein. Note=Localizes to intracellular membranes. Plasma membrane (GO:0005886); Microsome (GO:0005792); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10350628,10350628,10350628,10350628,15598749 plasma membrane 28 2 endoplasmic reticulum. golgi apparatus. mitochondrion. plasma membrane multiple Bilateria Eukaryota Eukaryota ESYT2 HGNC:22211 extended synaptotagmin-like protein 2 A0FGR8 Cell membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 15598749 plasma membrane 100 2 mitochondrion. plasma membrane multiple Bilateria Eukaryota Eukaryota ESYT3 HGNC:24295 extended synaptotagmin-like protein 3 A0FGR9 Cell membrane; Single-pass membrane protein. plasma membrane 100 2 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota ETAA1 HGNC:24648 Ewing tumor-associated antigen 1 Q9NY74 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Euteleostomi ETF1 HGNC:3477 eukaryotic translation termination factor 1 P62495 Cytoplasm. Ribosome (GO:0005840); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 12356746,12426392,15635413,11790298 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ETFA HGNC:3481 electron-transfer-flavoprotein, alpha polypeptide P13804 Mitochondrion matrix. Mitochondrion (GO:0005739) 3170610,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ETFB HGNC:3482 electron-transfer-flavoprotein, beta polypeptide P38117 Mitochondrion matrix. Mitochondrion (GO:0005739) 8617498,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ETFDH HGNC:3483 electron-transferring-flavoprotein dehydrogenase Q16134 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 8306995,15598749 mitochondrion 64 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ETHE1 HGNC:23287 ethylmalonic encephalopathy 1 O95571 Cytoplasm. Nucleus. Mitochondrion matrix. Note=According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14732903,12398897,12398897 mitochondrion 53 0 cytoplasm. mitochondrion. nucleus multiple Eutheria Cell.Organisms Cell.Organisms ETNK1 HGNC:24649 ethanolamine kinase 1 Q9HBU6 Cytoplasm. Cytoplasm (GO:0005737) 11044454 cytoplasm 100 1 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ETNK2 HGNC:25575 ethanolamine kinase 2 Q9NVF9 cytoplasm 50 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms ETNPPL HGNC:14404 ethanolamine-phosphate phospho-lyase Q8TBG4 Mitochondrion (Potential). mitochondrion 32 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms ETS1 HGNC:3488 v-ets avian erythroblastosis virus E26 oncogene homolog 1 P14921 Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 3285299,10698492,15247905 nucleus 99 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa ETS2 HGNC:3489 v-ets avian erythroblastosis virus E26 oncogene homolog 2 P15036 Nucleus. Nucleus (GO:0005634) 3285299 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Metazoa ETV1 HGNC:3490 ets variant 1 P50549 Nucleus (Probable). Nucleus (GO:0005634) 7651741 nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa ETV2 HGNC:3491 ets variant 2 O00321 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12087183,12087183 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Metazoa ETV3 HGNC:3492 ets variant 3 P41162 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Tetrapoda Tetrapoda Metazoa ETV3L HGNC:33834 ets variant 3-like Q6ZN32 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus NA NA Metazoa ETV4 HGNC:3493 ets variant 4 P43268 Nucleus. Nucleus (GO:0005634); Extracellular (GO:0005576) ,14718574 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Metazoa ETV5 HGNC:3494 ets variant 5 P41161 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus NA NA Metazoa ETV6 HGNC:3495 ets variant 6 P41212 Nucleus. Nucleus (GO:0005634) 10377438,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa ETV7 HGNC:18160 ets variant 7 Q9Y603 Nucleus. Nucleus (GO:0005634) 10828014,11108721 nucleus 100 0 nucleus nucleus Amniota Bilateria Metazoa EVA1A HGNC:25816 eva-1 homolog A (C. elegans) Q9H8M9 Endoplasmic reticulum membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783) 17492404,17492404 secreted 33 1 endoplasmic reticulum. endoplasmic reticulum membrane. lysosome. lysosome membrane multiple Euteleostomi Euteleostomi Craniata EVA1B HGNC:25558 eva-1 homolog B (C. elegans) Q9NVM1 Membrane; Single-pass membrane protein (Potential). nucleus 20 1 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi EVA1C HGNC:13239 eva-1 homolog C (C. elegans) P58658 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 27 1 cytoplasm cytoplasm Chordata Bilateria Eukaryota EVC HGNC:3497 Ellis van Creveld syndrome P57679 Cell membrane; Single-pass membrane protein (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cell projection, cilium (By similarity). Cell projection, cilium membrane (By similarity). Note=EVC2 is required for the localization of EVC at the base of primary cilia (By similarity). cytoplasm 9 2 cytoplasm cytoplasm Amniota Euteleostomi Deuterostomia EVC2 HGNC:19747 Ellis van Creveld syndrome 2 Q86UK5 Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cell projection, cilium (By similarity). Cell projection, cilium membrane (By similarity). Nucleus (By similarity). cytoplasm 14 2 cytoplasm cytoplasm Amniota Euteleostomi Bilateria EVI2A HGNC:3499 ecotropic viral integration site 2A P22794 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 2117566 plasma membrane 10 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Tetrapoda EVI2B HGNC:3500 ecotropic viral integration site 2B P34910 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1903357 plasma membrane 61 1 plasma membrane plasma membrane Eutheria Tetrapoda Amniota EVI5 HGNC:3501 ecotropic viral integration site 5 O60447 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis. cytoplasm 22 2 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EVI5L HGNC:30464 ecotropic viral integration site 5-like Q96CN4 cytoplasm 19 2 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EVL HGNC:20234 Enah/Vasp-like Q9UI08 Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10945997,10945997 secreted 35 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota EVPL HGNC:3503 envoplakin Q92817 Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11062259,11062259,11062259,8707850,9115270,9412476 cytoplasm 4 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa EVPLL HGNC:35236 envoplakin-like A8MZ36 cytoplasm 5 0 cytoplasm cytoplasm NA NA Bilateria EVX1 HGNC:3506 even-skipped homeobox 1 P49640 Nucleus. Nucleus (GO:0005634) 7499236 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta EVX2 HGNC:3507 even-skipped homeobox 2 Q03828 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa EWSR1 HGNC:3508 EWS RNA-binding protein 1 Q01844 Nucleus. Cytoplasm. Cell membrane. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleolus (GO:0005730) 9341188,17081983,11278906,11278906,15635413 nucleus 53 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms EXD1 HGNC:28507 exonuclease 3'-5' domain containing 1 Q8NHP7 nucleus 53 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms EXD2 HGNC:20217 exonuclease 3'-5' domain containing 2 Q9NVH0 nucleus 13 2 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms EXD3 HGNC:26023 exonuclease 3'-5' domain containing 3 Q8N9H8 Nucleus (GO:0005634) nucleus 20 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms EXO1 HGNC:3511 exonuclease 1 Q9UQ84 Nucleus. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase. Nucleus (GO:0005634) 11429708 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms EXO5 HGNC:26115 exonuclease 5 Q9H790 Nucleus. Cytoplasm, cytosol. Note=Localizes to repair foci in response to DNA damage. nucleus 31 0 cytoplasm. nucleus multiple Mammalia Eukaryota Eukaryota EXOC1 HGNC:30380 exocyst complex component 1 Q9NV70 Cytoplasm (GO:0005737) 11493706 nucleus 70 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota EXOC2 HGNC:24968 exocyst complex component 2 Q96KP1 Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14525976,11493706,17081983,17081983 nucleus 66 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota EXOC3 HGNC:30378 exocyst complex component 3 O60645 Plasma membrane (GO:0005886) 8982167 cytoplasm 10 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota EXOC3L1 HGNC:27540 exocyst complex component 3-like 1 Q86VI1 Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Colocalizes with insulin granules (By similarity). cytoplasm 38 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta EXOC3L2 HGNC:30162 exocyst complex component 3-like 2 Q2M3D2 nucleus 69 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa EXOC3L4 HGNC:20120 exocyst complex component 3-like 4 Q17RC7 nucleus 57 0 nucleus nucleus Theria Euteleostomi Bilateria EXOC4 HGNC:30389 exocyst complex component 4 Q96A65 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Microsome (GO:0005792); Zymogen granule (GO:0042588) 12687004,9630218,9630218,12687004,12687004,16278343 nucleus 87 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota EXOC5 HGNC:10696 exocyst complex component 5 O00471 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 9119050,14662749,14662749,14662749 cytoplasm 100 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Eukaryota EXOC6 HGNC:23196 exocyst complex component 6 Q8TAG9 Cytoplasm (GO:0005737) 15292201 nucleus 92 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota EXOC6B HGNC:17085 exocyst complex component 6B Q9Y2D4 nucleus 92 0 nucleus nucleus Eukaryota Eukaryota Eukaryota EXOC7 HGNC:23214 exocyst complex component 7 Q9UPT5 Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 15705715,15705715 cytoplasm 35 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota EXOC8 HGNC:24659 exocyst complex component 8 Q8IYI6 Cytoplasm. Cell projection, growth cone (By similarity). Note=Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14525976,12954101,12954101,12954101 nucleus 73 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Eukaryota EXOG HGNC:3347 endo/exonuclease (5'-3'), endonuclease G-like Q9Y2C4 Mitochondrion inner membrane. secreted 32 0 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms EXOSC1 HGNC:17286 exosome component 1 Q9Y3B2 Nucleus, nucleolus. Nucleus (Probable). Cytoplasm (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11110791,11110791,15635413 cytoplasm 21 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EXOSC10 HGNC:9138 exosome component 10 Q01780 Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. Nucleolus (GO:0005730); Nucleoplasm (GO:0005654) 1383382,1383382 nucleus 24 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms EXOSC2 HGNC:17097 exosome component 2 Q13868 Cytoplasm. Nucleus, nucleolus. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11719186,12788944,11719186,15635413 cytoplasm 23 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EXOSC3 HGNC:17944 exosome component 3 Q9NQT5 Cytoplasm. Nucleus, nucleolus. Nucleus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11110791,11790298,11110791,11110791 cytoplasm 28 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota EXOSC4 HGNC:18189 exosome component 4 Q9NPD3 Cytoplasm. Nucleus, nucleolus. Nucleus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11110791,15635413,11790298,11110791,12788944,11110791 mitochondrion 12 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms NA EXOSC5 HGNC:24662 exosome component 5 Q9NQT4 Nucleus, nucleolus. Cytoplasm (Probable). Nucleus (Probable). Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11110791,15635413,11110791,11110791 mitochondrion 17 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms EXOSC6 HGNC:19055 exosome component 6 Q5RKV6 Cytoplasm (Probable). Nucleus, nucleolus (Probable). Nucleus (Probable). Nucleus (GO:0005634) 11719186 mitochondrion 14 1 cytoplasm. nucleus multiple NA NA Eukaryota EXOSC7 HGNC:28112 exosome component 7 Q15024 Nucleus, nucleolus. Cytoplasm (Probable). Nucleus (Probable). Nucleolus (GO:0005730); Nucleus (GO:0005634) 11812149,15635413,11790298,12788944 nucleus 50 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms EXOSC8 HGNC:17035 exosome component 8 Q96B26 Cytoplasm. Nucleus. Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730) 15635413 nucleus 58 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms EXOSC9 HGNC:9137 exosome component 9 Q06265 Cytoplasm. Nucleus, nucleolus. Isoform 1: Nucleus, nucleolus. Isoform 2: Nucleus, nucleolus. Isoform 3: Nucleus. Note=Excluded from the nucleolus. Nucleoplasm (GO:0005654); Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12788944,12788944,2007859,15635413,11782436,17081983,11782436,12788944 nucleus 94 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms EXPH5 HGNC:30578 exophilin 5 Q8NEV8 Nucleus (GO:0005634) 11773082 nucleus 93 0 nucleus nucleus Amniota Amniota Euteleostomi EXT1 HGNC:3512 exostosin glycosyltransferase 1 Q16394 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9620772,10878610,9703997,10639137,10639137,10679296,11391482 endoplasmic reticulum membrane 32 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Cell.Organisms EXT2 HGNC:3513 exostosin glycosyltransferase 2 Q93063 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 10639137,11391482,10679296,10639137,9756849,10639137 endoplasmic reticulum membrane 42 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. secreted multiple Euteleostomi Eukaryota Cell.Organisms EXTL1 HGNC:3515 exostosin-like glycosyltransferase 1 Q92935 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 19 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Cell.Organisms EXTL2 HGNC:3516 exostosin-like glycosyltransferase 2 Q9UBQ6 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Processed exostosin-like 2: Secreted. Note=A soluble form is found in the serum. Extracellular matrix (GO:0005578) 10318803 endoplasmic reticulum membrane 18 1 secreted secreted Euteleostomi Eukaryota Eukaryota EXTL3 HGNC:3518 exostosin-like glycosyltransferase 3 O43909 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11257457,11257457 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum membrane. nucleus multiple Bilateria Bilateria Eukaryota EYA1 HGNC:3519 eyes absent homolog 1 (Drosophila) Q99502 Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15226428,11734542,15492887,11734542,15492887 nucleus 52 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota EYA2 HGNC:3520 eyes absent homolog 2 (Drosophila) O00167 Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10906137,10906137 nucleus 42 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota EYA3 HGNC:3521 eyes absent homolog 3 (Drosophila) Q99504 Cytoplasm (By similarity). Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10490620,10490620 nucleus 40 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota EYA4 HGNC:3522 eyes absent homolog 4 (Drosophila) O95677 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15492887,15492887 nucleus 50 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota EYS HGNC:21555 eyes shut homolog (Drosophila) Q5T1H1 Secreted (Probable). Note=Localizes in the photoreceptor cell layer. secreted 24 0 secreted secreted Amniota Deuterostomia Eukaryota EZH1 HGNC:3526 enhancer of zeste homolog 1 (Drosophila) Q92800 Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3. Nucleus (GO:0005634) ,,16565076, nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms EZH2 HGNC:3527 enhancer of zeste homolog 2 (Drosophila) Q15910 Nucleus. Nucleus (GO:0005634) ,9584199,16565076, nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms EZR HGNC:12691 ezrin P15311 Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 8089177,1762625,15598749 cytoplasm 23 0 cytoplasm. mitochondrion multiple Bilateria Bilateria Eukaryota F10 HGNC:3528 coagulation factor X P00742 Secreted. Extracellular (GO:0005576) 1698100 secreted 100 0 secreted secreted Tetrapoda Bilateria Cell.Organisms F11 HGNC:3529 coagulation factor XI P03951 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9593722,12517745,9593722 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms F11R HGNC:14685 F11 receptor Q9Y624 Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells. Cell junction (GO:0030054); Cell surface (GO:0009986) 12750158,17057644,12750158 secreted 12 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa F12 HGNC:3530 coagulation factor XII (Hageman factor) P00748 Secreted. Extracellular (GO:0005576) 3198120,14718574,16199891,16188874 secreted 100 0 secreted secreted Mammalia Mammalia Cell.Organisms F13A1 HGNC:3531 coagulation factor XIII, A1 polypeptide P00488 Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2877457,11853093,9721590,8797098,7873582,11372678,8797098 cytoplasm 20 0 cytoplasm. nucleus. secreted multiple Theria Euteleostomi Eukaryota F13B HGNC:3534 coagulation factor XIII, B polypeptide P05160 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 8847818,7873582,9037894,1359667,8797098,16188874,11313256,11313256 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Amniota Deuterostomia Holozoa F2 HGNC:3535 coagulation factor II (thrombin) P00734 Secreted, extracellular space. Extracellular (GO:0005576) 6132925,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms F2R HGNC:3537 coagulation factor II (thrombin) receptor P25116 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768) 9038223,12058063 plasma membrane 100 7 endosome. plasma membrane multiple Human Euteleostomi Eumetazoa F2RL1 HGNC:3538 coagulation factor II (thrombin) receptor-like 1 P55085 Cell membrane; Multi-pass membrane protein. Cell surface (GO:0009986); Late endosome (GO:0005770); Lysosome (GO:0005764); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794) 15708858,15708858,15708858,8703006,8615752,8703006,8615752,8703006,15708858 plasma membrane 100 7 endosome. golgi apparatus. lysosome. plasma membrane multiple Euteleostomi Euteleostomi Metazoa F2RL2 HGNC:3539 coagulation factor II (thrombin) receptor-like 2 O00254 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cell junction (GO:0030054) 11544528,17057644,17057644 plasma membrane 100 7 cytoplasm. plasma membrane multiple Tetrapoda Euteleostomi Metazoa F2RL3 HGNC:3540 coagulation factor II (thrombin) receptor-like 3 Q96RI0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9618465 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa F3 HGNC:3541 coagulation factor III (thromboplastin, tissue factor) P13726 Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886) 4023720,15664864 secreted 21 1 plasma membrane. secreted multiple Amniota Euteleostomi Craniata F5 HGNC:3542 coagulation factor V (proaccelerin, labile factor) P12259 Secreted (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10521265,10521265,2675384,2675384 secreted 69 0 endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms F7 HGNC:3544 coagulation factor VII (serum prothrombin conversion accelerator) P08709 Secreted. Extracellular (GO:0005576) 11698657,3037537 secreted 100 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms F8 HGNC:3546 coagulation factor VIII, procoagulant component P00451 Secreted, extracellular space. Extracellular (GO:0005576) 14718574 secreted 100 0 secreted secreted Amniota Euteleostomi NA F8A1 HGNC:3547 coagulation factor VIII-associated 1 P23610 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11035034,11035034 nucleus 40 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA F8A2 HGNC:31849 coagulation factor VIII-associated 2 P23610 nucleus 40 0 nucleus nucleus Deuterostomia Eukaryota NA F8A3 HGNC:31850 coagulation factor VIII-associated 3 P23610 nucleus 40 0 nucleus nucleus Deuterostomia Eukaryota NA F9 HGNC:3551 coagulation factor IX P00740 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9834200,9834200,9834200 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Deuterostomia Cell.Organisms FA2H HGNC:21197 fatty acid 2-hydroxylase Q7L5A8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Microsome (GO:0005792) 15337768 endoplasmic reticulum membrane 31 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Cell.Organisms FAAH HGNC:3553 fatty acid amide hydrolase O00519 Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. Plasma membrane (GO:0005886) 11352748 cytoplasm 12 1 cytoplasm. endomembrane system. plasma membrane multiple Chordata Eukaryota Cell.Organisms FAAH2 HGNC:26440 fatty acid amide hydrolase 2 Q6GMR7 Membrane; Single-pass membrane protein (Potential). mitochondrion 12 0 mitochondrion mitochondrion Catarrhini Cell.Organisms Cell.Organisms FABP1 HGNC:3555 fatty acid binding protein 1, liver P07148 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11461829,1699834,11354243 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria FABP12 HGNC:34524 fatty acid binding protein 12 A6NFH5 cytoplasm 53 0 cytoplasm cytoplasm Theria Theria Eumetazoa FABP2 HGNC:3556 fatty acid binding protein 2, intestinal P12104 Cytoplasm. Cytoplasm (GO:0005737) 3838313,9806794,12634920 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Bilateria FABP3 HGNC:3557 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) P05413 Cytoplasm. Cytoplasm (GO:0005737) 8262516,7922029,1526991 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa FABP4 HGNC:3559 fatty acid binding protein 4, adipocyte P15090 Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). Cytoplasm (GO:0005737) 2481498 cytoplasm 63 0 cytoplasm. nucleus multiple Theria Bilateria Eumetazoa FABP5 HGNC:3560 fatty acid binding protein 5 (psoriasis-associated) Q01469 Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 8092987,8726632,10191275,10191275 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Amniota Amniota Bilateria FABP6 HGNC:3561 fatty acid binding protein 6, ileal P51161 Isoform 1: Cytoplasm. Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells. Cytoplasm (GO:0005737) 10806391 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Bilateria FABP7 HGNC:3562 fatty acid binding protein 7, brain O15540 Cytoplasm. Cytoplasm (GO:0005737) 10497880 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eumetazoa FABP9 HGNC:3563 fatty acid binding protein 9, testis Q0Z7S8 Cytoplasm (Potential). cytoplasm 54 0 cytoplasm cytoplasm Theria Theria Eumetazoa FADD HGNC:3573 Fas (TNFRSF6)-associated via death domain Q13158 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Early endosome (GO:0005769) 11859150,17159907,16498403,11740202,16498403 cytoplasm 24 0 cytoplasm. endosome multiple Tetrapoda Deuterostomia Eumetazoa FADS1 HGNC:3574 fatty acid desaturase 1 O60427 Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion. Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) endoplasmic reticulum membrane 51 4 endoplasmic reticulum membrane. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms FADS2 HGNC:3575 fatty acid desaturase 2 O95864 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 9867867 endoplasmic reticulum membrane 85 4 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms FADS3 HGNC:3576 fatty acid desaturase 3 Q9Y5Q0 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 54 4 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Cell.Organisms FADS6 HGNC:30459 fatty acid desaturase 6 Q8N9I5 Membrane; Multi-pass membrane protein (Potential). secreted 28 6 n/a n/a Tetrapoda Euteleostomi Cell.Organisms FAF1 HGNC:3578 Fas (TNFRSF6) associated factor 1 Q9UNN5 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 15596450,15596450,15596450 cytoplasm 17 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota FAF2 HGNC:24666 Fas associated factor family member 2 Q96CS3 Cytoplasm. Lipid droplet. Endoplasmic reticulum. Cytoplasm (GO:0005737) 12372427 cytoplasm 15 1 cytoplasm. endoplasmic reticulum. lipid droplet multiple Eukaryota Eukaryota Eukaryota FAH HGNC:3579 fumarylacetoacetate hydrolase (fumarylacetoacetase) P16930 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 7296877,14718574 cytoplasm 78 0 cytoplasm. secreted multiple Bilateria Cell.Organisms Cell.Organisms FAHD1 HGNC:14169 fumarylacetoacetate hydrolase domain containing 1 Q6P587 Mitochondrion. Cytoplasm, cytosol. mitochondrion 28 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms FAHD2A HGNC:24252 fumarylacetoacetate hydrolase domain containing 2A Q96GK7 mitochondrion 21 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms FAHD2B HGNC:25318 fumarylacetoacetate hydrolase domain containing 2B Q6P2I3 mitochondrion 21 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms FAIM HGNC:18703 Fas apoptotic inhibitory molecule Q9NVQ4 Cytoplasm (By similarity). cytoplasm 87 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa FAIM2 HGNC:17067 Fas apoptotic inhibitory molecule 2 Q9BWQ8 Cell membrane; Multi-pass membrane protein (By similarity). Membrane raft. Cell junction, synapse, postsynaptic cell membrane (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10535980,10535980,10535980,10535980 golgi apparatus membrane 22 7 cytoplasm. endoplasmic reticulum. golgi apparatus. plasma membrane multiple Chordata Bilateria Cell.Organisms FAIM3 HGNC:14315 Fas apoptotic inhibitory molecule 3 O60667 Isoform 1: Membrane; Single-pass membrane protein. Isoform 3: Secreted. Note=Detected in the serum. Plasma membrane (GO:0005886) 9586636 plasma membrane 25 1 plasma membrane. secreted multiple Theria Theria Euteleostomi FAM101A HGNC:27051 family with sequence similarity 101, member A Q6ZTI6 nucleus 56 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria FAM101B HGNC:28705 family with sequence similarity 101, member B Q8N5W9 nucleus 40 0 nucleus nucleus Human Human NA FAM102A HGNC:31419 family with sequence similarity 102, member A Q5T9C2 nucleus 43 1 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FAM102B HGNC:27637 family with sequence similarity 102, member B Q5T8I3 nucleus 52 0 nucleus nucleus Chordata Opisthokonta Opisthokonta FAM103A1 HGNC:31022 family with sequence similarity 103, member A1 Q9BTL3 Nucleus. nucleus 100 0 nucleus nucleus Amniota Amniota Deuterostomia FAM104A HGNC:25918 family with sequence similarity 104, member A Q969W3 nucleus 69 0 nucleus nucleus Amniota Amniota Craniata FAM104B HGNC:25085 family with sequence similarity 104, member B Q5XKR9 nucleus 51 0 nucleus nucleus Human Human Craniata FAM105A HGNC:25629 family with sequence similarity 105, member A Q9NUU6 cytoplasm 28 1 cytoplasm cytoplasm Tetrapoda Tetrapoda Bilateria FAM107A HGNC:30827 family with sequence similarity 107, member A O95990 Nucleus. Nucleus (GO:0005634) 10564580 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Bilateria FAM107B HGNC:23726 family with sequence similarity 107, member B Q9H098 nucleus 46 0 nucleus nucleus Human Bilateria Bilateria FAM109A HGNC:26509 family with sequence similarity 109, member A Q8N4B1 Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin- coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. nucleus 22 0 endosome. golgi apparatus multiple Bilateria Opisthokonta Eukaryota FAM109B HGNC:27161 family with sequence similarity 109, member B Q6ICB4 Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin- coated vesicle. Note=Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. cytoplasm 44 0 endosome. golgi apparatus multiple Bilateria Opisthokonta NA FAM110A HGNC:16188 family with sequence similarity 110, member A Q9BQ89 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles. cytoplasm 100 0 cytoplasm cytoplasm Eutheria Euteleostomi Craniata FAM110B HGNC:28587 family with sequence similarity 110, member B Q8TC76 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Centrosome (GO:0005813) 17499476,17499476 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria FAM110C HGNC:33340 family with sequence similarity 110, member C Q1W6H9 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles. Colocalizes with AKT1 at the cell cortex. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Microtubule cytoskeleton (GO:0015630); Nucleus (GO:0005634) 17499476,17499476,17499476,17499476 cytoplasm 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria FAM110D HGNC:25860 family with sequence similarity 110, member D Q8TAY7 cytoplasm 26 0 cytoplasm cytoplasm Eutheria Euteleostomi Euteleostomi FAM111A HGNC:24725 family with sequence similarity 111, member A Q96PZ2 Cytoplasm. Nucleus. nucleus 50 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Chordata FAM111B HGNC:24200 family with sequence similarity 111, member B Q6SJ93 nucleus 50 0 nucleus nucleus Mammalia Euteleostomi Chordata FAM114A1 HGNC:25087 family with sequence similarity 114, member A1 Q8IWE2 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 17081983 cytoplasm 74 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa FAM114A2 HGNC:1333 family with sequence similarity 114, member A2 Q9NRY5 cytoplasm 36 0 cytoplasm cytoplasm Amniota Bilateria Holozoa FAM115A HGNC:22201 family with sequence similarity 115, member A Q9Y4C2 cytoplasm 41 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms FAM115C HGNC:26878 family with sequence similarity 115, member C A6NFQ2 cytoplasm 38 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms FAM117A HGNC:24179 family with sequence similarity 117, member A Q9C073 nucleus 85 0 nucleus nucleus Theria Euteleostomi Eumetazoa FAM117B HGNC:14440 family with sequence similarity 117, member B Q6P1L5 plasma membrane 26 0 n/a n/a Euteleostomi Bilateria Eumetazoa FAM118A HGNC:1313 family with sequence similarity 118, member A Q9NWS6 Membrane; Single-pass membrane protein (Potential). cytoplasm 51 1 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms FAM118B HGNC:26110 family with sequence similarity 118, member B Q9BPY3 cytoplasm 42 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms FAM120A HGNC:13247 family with sequence similarity 120A Q9NZB2 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to plasma membrane upon ultraviolet exposure. Nucleus (GO:0005634) 17081983 nucleus 13 1 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Opisthokonta FAM120AOS HGNC:23389 family with sequence similarity 120A opposite strand Q5T036 mitochondrion 45 0 mitochondrion mitochondrion Human Catarrhini Craniata FAM120B HGNC:21109 family with sequence similarity 120B Q96EK7 Nucleus (By similarity). nucleus 66 2 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms FAM120C HGNC:16949 family with sequence similarity 120C Q9NX05 Nucleus (GO:0005634) 17000644 nucleus 13 0 nucleus nucleus Deuterostomia Deuterostomia NA FAM122A HGNC:23490 family with sequence similarity 122A Q96E09 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 92 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Bilateria FAM122B HGNC:30490 family with sequence similarity 122B Q7Z309 nucleus 91 0 nucleus nucleus Eutheria Tetrapoda Bilateria FAM122C HGNC:25202 family with sequence similarity 122C Q6P4D5 nucleus 42 2 nucleus nucleus Human Human Bilateria FAM124A HGNC:26413 family with sequence similarity 124A Q86V42 nucleus 84 0 nucleus nucleus Tetrapoda Deuterostomia Eumetazoa FAM124B HGNC:26224 family with sequence similarity 124B Q9H5Z6 nucleus 79 0 nucleus nucleus Human Human Eumetazoa FAM126A HGNC:24587 family with sequence similarity 126, member A Q9BYI3 Cytoplasm. Membrane. Note=According to PubMed:10910037, it is mainly cytoplasmic while according to PubMed:16951682, it is a membrane protein. Cytoplasm (GO:0005737) 10910037 nucleus 59 1 cytoplasm cytoplasm Chordata Bilateria Holozoa FAM126B HGNC:28593 family with sequence similarity 126, member B Q8IXS8 nucleus 61 1 nucleus nucleus Theria Euteleostomi Eukaryota FAM127A HGNC:2569 family with sequence similarity 127, member A A6ZKI3 nucleus 51 0 nucleus nucleus Homininae Homininae Opisthokonta FAM127B HGNC:24514 family with sequence similarity 127, member B Q9BWD3 nucleus 53 0 nucleus nucleus Eutheria Eutheria Opisthokonta FAM127C HGNC:33156 family with sequence similarity 127, member C Q17RB0 nucleus 54 0 nucleus nucleus Eutheria Eutheria Opisthokonta FAM129A HGNC:16784 family with sequence similarity 129, member A Q9BZQ8 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota FAM129B HGNC:25282 family with sequence similarity 129, member B Q96TA1 Cytoplasm, cytosol. Cell junction, adherens junction. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation. Nucleus (GO:0005634) 15302935 cytoplasm 26 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota FAM129C HGNC:24130 family with sequence similarity 129, member C Q86XR2 cytoplasm 13 0 cytoplasm cytoplasm Mammalia Mammalia Opisthokonta FAM131A HGNC:28308 family with sequence similarity 131, member A Q6UXB0 Secreted (Potential). secreted 33 0 secreted secreted Mammalia Euteleostomi Craniata FAM131B HGNC:22202 family with sequence similarity 131, member B Q86XD5 nucleus 59 0 nucleus nucleus Tetrapoda Euteleostomi Euteleostomi FAM131C HGNC:26717 family with sequence similarity 131, member C Q96AQ9 nucleus 61 0 nucleus nucleus Mammalia Euteleostomi Euteleostomi FAM132A HGNC:32308 family with sequence similarity 132, member A Q5T7M4 Secreted (Potential). secreted 34 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FAM132B HGNC:26727 family with sequence similarity 132, member B Q4G0M1 Secreted (By similarity). secreted 67 0 secreted secreted Human Human Eumetazoa FAM133A HGNC:26748 family with sequence similarity 133, member A Q8N9E0 nucleus 12 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa FAM133B HGNC:28629 family with sequence similarity 133, member B Q5BKY9 Cytoplasm (GO:0005737) 17081983 nucleus 10 0 cytoplasm cytoplasm NA NA Metazoa FAM134A HGNC:28450 family with sequence similarity 134, member A Q8NC44 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 golgi apparatus membrane 21 4 nucleus nucleus Euteleostomi Euteleostomi Bilateria FAM134B HGNC:25964 family with sequence similarity 134, member B Q9H6L5 Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 91 5 golgi apparatus membrane golgi apparatus membrane Mammalia Euteleostomi Bilateria FAM134C HGNC:27258 family with sequence similarity 134, member C Q86VR2 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 26 3 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Eumetazoa FAM135A HGNC:21084 family with sequence similarity 135, member A Q9P2D6 nucleus 25 1 nucleus nucleus Bilateria Bilateria Eukaryota FAM135B HGNC:28029 family with sequence similarity 135, member B Q49AJ0 cytoplasm 13 1 cytoplasm cytoplasm Human Eukaryota Eukaryota FAM136A HGNC:25911 family with sequence similarity 136, member A Q96C01 Mitochondrion (By similarity). Nucleus (GO:0005634) mitochondrion 87 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota FAM13A HGNC:19367 family with sequence similarity 13, member A O94988 cytoplasm 19 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota FAM13B HGNC:1335 family with sequence similarity 13, member B Q9NYF5 Nucleus (GO:0005634) 11087669 cytoplasm 13 0 nucleus nucleus Mammalia Euteleostomi Eukaryota FAM13C HGNC:19371 family with sequence similarity 13, member C Q8NE31 nucleus 90 0 nucleus nucleus Tetrapoda Tetrapoda Eumetazoa FAM149A HGNC:24527 family with sequence similarity 149, member A A5PLN7 nucleus 79 0 nucleus nucleus Tetrapoda Deuterostomia Eumetazoa FAM149B1 HGNC:29162 family with sequence similarity 149, member B1 Q96BN6 nucleus 86 0 nucleus nucleus Amniota Euteleostomi Opisthokonta FAM150A HGNC:33775 family with sequence similarity 150, member A Q6UXT8 Secreted (Potential). secreted 24 0 secreted secreted Mammalia Mammalia Euteleostomi FAM150B HGNC:27683 family with sequence similarity 150, member B Q6UX46 Secreted (Potential). secreted 90 0 secreted secreted Human Human Euteleostomi FAM151A HGNC:25032 family with sequence similarity 151, member A Q8WW52 Membrane; Single-pass membrane protein (Potential). cytoplasm 17 1 cytoplasm cytoplasm Theria Euteleostomi Holozoa FAM151B HGNC:33716 family with sequence similarity 151, member B Q6UXP7 cytoplasm 29 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa FAM153A HGNC:29940 family with sequence similarity 153, member A Q9UHL3 nucleus 47 0 nucleus nucleus Human Human Primates FAM153B HGNC:27323 family with sequence similarity 153, member B P0C7A2 nucleus 64 0 nucleus nucleus Catarrhini Catarrhini Primates FAM153C HGNC:33936 family with sequence similarity 153, member C Q494X1 nucleus 59 0 nucleus nucleus Human Human Primates FAM154A HGNC:28566 family with sequence similarity 154, member A Q8IYX7 secreted 60 0 secreted secreted Amniota Bilateria Metazoa FAM154B HGNC:33727 family with sequence similarity 154, member B Q658L1 secreted 47 0 secreted secreted Deuterostomia Eukaryota Metazoa FAM155A HGNC:33877 family with sequence similarity 155, member A B1AL88 Membrane; Multi-pass membrane protein (Potential). secreted 91 2 n/a n/a Tetrapoda Euteleostomi Bilateria FAM155B HGNC:30701 family with sequence similarity 155, member B O75949 Membrane; Multi-pass membrane protein (Potential). secreted 95 2 n/a n/a Human Human Bilateria FAM156A HGNC:30114 family with sequence similarity 156, member A Q8NDB6 Membrane; Single-pass membrane protein (Potential). nucleus 77 0 nucleus nucleus Euarchontoglires Eutheria Boreoeutheria FAM156B HGNC:31962 family with sequence similarity 156, member B Q8NDB6 Membrane; Single-pass membrane protein (Potential). nucleus 77 0 nucleus nucleus Euarchontoglires Eutheria Boreoeutheria FAM159A HGNC:28757 family with sequence similarity 159, member A Q6UWV7 Membrane; Multi-pass membrane protein (Potential). secreted 74 1 secreted secreted Euarchontoglires Amniota Deuterostomia FAM159B HGNC:34236 family with sequence similarity 159, member B A6NKW6 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 25 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Human Deuterostomia FAM160A1 HGNC:34237 family with sequence similarity 160, member A1 Q05DH4 secreted 68 0 secreted secreted NA NA Opisthokonta FAM160A2 HGNC:25378 family with sequence similarity 160, member A2 Q8N612 secreted 43 1 secreted secreted Bilateria Bilateria Opisthokonta FAM160B1 HGNC:29320 family with sequence similarity 160, member B1 Q5W0V3 secreted 48 0 secreted secreted Deuterostomia Bilateria Eukaryota FAM160B2 HGNC:16492 family with sequence similarity 160, member B2 Q86V87 secreted 38 0 secreted secreted Deuterostomia Bilateria Eukaryota FAM161A HGNC:25808 family with sequence similarity 161, member A Q3B820 Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Note=Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium. nucleus 82 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota FAM161B HGNC:19854 family with sequence similarity 161, member B Q96MY7 nucleus 64 0 nucleus nucleus Theria Eukaryota Eumetazoa FAM162A HGNC:17865 family with sequence similarity 162, member A Q96A26 Membrane; Single-pass membrane protein (Potential). Mitochondrion. mitochondrion 49 1 mitochondrion mitochondrion Euteleostomi Bilateria Eumetazoa FAM162B HGNC:21549 family with sequence similarity 162, member B Q5T6X4 Membrane; Single-pass membrane protein (Potential). mitochondrion 32 1 mitochondrion mitochondrion Human Human Bilateria FAM163A HGNC:28274 family with sequence similarity 163, member A Q96GL9 Membrane; Single-pass membrane protein (Potential). nucleus 51 1 nucleus nucleus Amniota Euteleostomi Craniata FAM163B HGNC:33277 family with sequence similarity 163, member B P0C2L3 Membrane; Single-pass membrane protein (Potential). nucleus 51 1 nucleus nucleus Mammalia Euteleostomi Craniata FAM166A HGNC:33818 family with sequence similarity 166, member A Q6J272 secreted 30 0 secreted secreted Amniota Amniota Eumetazoa FAM166B HGNC:34242 family with sequence similarity 166, member B A8MTA8 secreted 54 0 secreted secreted Eutheria Bilateria Opisthokonta FAM167A HGNC:15549 family with sequence similarity 167, member A Q96KS9 nucleus 64 0 nucleus nucleus Chordata Chordata Eumetazoa FAM167B HGNC:28133 family with sequence similarity 167, member B Q9BTA0 nucleus 50 0 nucleus nucleus Human Human Deuterostomia FAM168A HGNC:28999 family with sequence similarity 168, member A Q92567 nucleus 72 0 nucleus nucleus Euteleostomi Euteleostomi Craniata FAM168B HGNC:27016 family with sequence similarity 168, member B A1KXE4 Cytoplasm, perinuclear region (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Cell projection, axon (By similarity). Note=Expressed in neuronal cell bodies and axonal fibers (By similarity). nucleus 72 0 nucleus nucleus Euteleostomi Euteleostomi Craniata FAM169A HGNC:29138 family with sequence similarity 169, member A Q9Y6X4 Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina. nucleus 12 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms FAM169B HGNC:26835 family with sequence similarity 169, member B Q8N8A8 cytoplasm 19 0 cytoplasm cytoplasm Human Euteleostomi Eumetazoa FAM170A HGNC:27963 family with sequence similarity 170, member A A1A519 nucleus 100 0 nucleus nucleus Theria Theria Amniota FAM170B HGNC:19736 family with sequence similarity 170, member B A6NMN3 nucleus 21 0 nucleus nucleus Homininae Mammalia Mammalia FAM171A1 HGNC:23522 family with sequence similarity 171, member A1 Q5VUB5 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 33 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Deuterostomia FAM171A2 HGNC:30480 family with sequence similarity 171, member A2 A8MVW0 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 37 1 plasma membrane plasma membrane Theria Euteleostomi Deuterostomia FAM171B HGNC:29412 family with sequence similarity 171, member B Q6P995 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 43 1 secreted secreted Amniota Euteleostomi Deuterostomia FAM172A HGNC:25365 family with sequence similarity 172, member A Q8WUF8 Secreted (Potential). cytoplasm 13 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota FAM173A HGNC:14152 family with sequence similarity 173, member A Q9BQD7 Membrane; Single-pass membrane protein (Potential). cytoplasm 24 1 cytoplasm cytoplasm Amniota Cell.Organisms Cell.Organisms FAM173B HGNC:27029 family with sequence similarity 173, member B Q6P4H8 Membrane; Single-pass membrane protein (Potential). cytoplasm 24 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms FAM174A HGNC:24943 family with sequence similarity 174, member A Q8TBP5 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 12975309 endoplasmic reticulum membrane 33 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Tetrapoda Craniata FAM174B HGNC:34339 family with sequence similarity 174, member B Q3ZCQ3 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 17 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata FAM175A HGNC:25829 family with sequence similarity 175, member A Q6UWZ7 Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota FAM175B HGNC:28975 family with sequence similarity 175, member B Q15018 Cytoplasm (GO:0005737) 17081983 nucleus 23 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota FAM177A1 HGNC:19829 family with sequence similarity 177, member A1 Q8N128 nucleus 63 0 nucleus nucleus Amniota Bilateria Eumetazoa FAM177B HGNC:34395 family with sequence similarity 177, member B A6PVY3 nucleus 65 0 nucleus nucleus Human Human Eumetazoa FAM178A HGNC:17814 family with sequence similarity 178, member A Q8IX21 Nucleus (GO:0005634) 17081983 nucleus 47 0 nucleus nucleus Euteleostomi Euteleostomi Deuterostomia FAM178B HGNC:28036 family with sequence similarity 178, member B Q8IXR5 nucleus 83 0 nucleus nucleus Theria Amniota Chordata FAM179A HGNC:33715 family with sequence similarity 179, member A Q6ZUX3 nucleus 84 0 nucleus nucleus Amniota Amniota Eukaryota FAM179B HGNC:19959 family with sequence similarity 179, member B Q9Y4F4 nucleus 86 0 nucleus nucleus Amniota Eukaryota Eukaryota FAM180A HGNC:33773 family with sequence similarity 180, member A Q6UWF9 Secreted (Potential). nucleus 24 0 nucleus nucleus Tetrapoda Euteleostomi Craniata FAM180B HGNC:34451 family with sequence similarity 180, member B Q6P0A1 Membrane; Single-pass membrane protein (Potential). nucleus 29 1 nucleus nucleus Catarrhini Theria Euteleostomi FAM181A HGNC:20491 family with sequence similarity 181, member A Q8N9Y4 nucleus 44 0 nucleus nucleus Theria Amniota Eumetazoa FAM181B HGNC:28512 family with sequence similarity 181, member B A6NEQ2 nucleus 64 0 nucleus nucleus Human Human Eumetazoa FAM183A HGNC:34347 family with sequence similarity 183, member A A6NL82 nucleus 35 0 nucleus nucleus Mammalia Deuterostomia Holozoa FAM183B HGNC:34511 family with sequence similarity 183, member B Q6ZVS7 nucleus 30 0 nucleus nucleus Human Human Holozoa FAM184A HGNC:20991 family with sequence similarity 184, member A Q8NB25 nucleus 19 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota FAM184B HGNC:29235 family with sequence similarity 184, member B Q9ULE4 cytoplasm 23 0 cytoplasm cytoplasm Human Human Eukaryota FAM185A HGNC:22412 family with sequence similarity 185, member A Q8N0U4 cytoplasm 12 0 cytoplasm cytoplasm NA NA Cell.Organisms FAM186A HGNC:26980 family with sequence similarity 186, member A A6NE01 secreted 25 0 secreted secreted Homininae Theria Cell.Organisms FAM186B HGNC:25296 family with sequence similarity 186, member B Q8IYM0 cytoplasm 10 0 cytoplasm cytoplasm Eutheria Mammalia Deuterostomia FAM187A HGNC:35153 family with sequence similarity 187, member A A6NFU0 Membrane; Single-pass type I membrane protein (Potential). secreted 20 1 secreted secreted Chordata Chordata Bilateria FAM187B HGNC:26366 family with sequence similarity 187, member B Q17R55 Membrane; Single-pass type I membrane protein (Potential). secreted 40 1 secreted secreted Theria Theria Chordata FAM188A HGNC:23578 family with sequence similarity 188, member A Q9H8M7 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12054670,12054670 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota FAM188B HGNC:21916 family with sequence similarity 188, member B Q4G0A6 nucleus 18 0 nucleus nucleus Amniota Eukaryota Eukaryota FAM188B2 HGNC:35475 family with sequence similarity 188, member B2 A8MYZ0 nucleus 12 0 nucleus nucleus NA NA Eukaryota FAM189A1 HGNC:29075 family with sequence similarity 189, member A1 O60320 Membrane; Multi-pass membrane protein (Potential). secreted 14 4 n/a n/a Euteleostomi Euteleostomi Eumetazoa FAM189A2 HGNC:24820 family with sequence similarity 189, member A2 Q15884 Membrane; Single-pass type I membrane protein (Potential). secreted 84 1 secreted secreted Amniota Euteleostomi Chordata FAM189B HGNC:1233 family with sequence similarity 189, member B P81408 Membrane; Multi-pass membrane protein (Potential). plasma membrane 49 4 plasma membrane plasma membrane Theria Euteleostomi NA FAM192A HGNC:29856 family with sequence similarity 192, member A Q9GZU8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 5 0 nucleus nucleus Bilateria Eukaryota Opisthokonta FAM193A HGNC:16822 family with sequence similarity 193, member A P78312 Nucleus (GO:0005634) cytoplasm 65 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Bilateria FAM193B HGNC:25524 family with sequence similarity 193, member B Q96PV7 Nucleus (GO:0005634) cytoplasm 14 0 cytoplasm cytoplasm Amniota Euteleostomi Metazoa FAM195A HGNC:14142 family with sequence similarity 195, member A Q9BUT9 nucleus 26 0 nucleus nucleus Chordata Chordata Bilateria FAM195B HGNC:28007 family with sequence similarity 195, member B C9JLW8 nucleus 35 0 nucleus nucleus NA NA Bilateria FAM196A HGNC:33859 family with sequence similarity 196, member A Q6ZSG2 nucleus 81 0 nucleus nucleus Tetrapoda Euteleostomi Craniata FAM196B HGNC:37271 family with sequence similarity 196, member B A6NMK8 nucleus 78 0 nucleus nucleus Mammalia Tetrapoda Craniata FAM198A HGNC:24485 family with sequence similarity 198, member A Q9UFP1 Secreted (Potential). nucleus 23 0 nucleus nucleus Mammalia Euteleostomi Deuterostomia FAM198B HGNC:25312 family with sequence similarity 198, member B Q6UWH4 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). nucleus 45 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Euteleostomi Deuterostomia FAM199X HGNC:25195 family with sequence similarity 199, X-linked Q6PEV8 nucleus 93 0 nucleus nucleus Chordata Chordata NA FAM19A1 HGNC:21587 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 Q7Z5A9 Secreted. Extracellular (GO:0005576) 15028294 secreted 100 0 secreted secreted Amniota Euteleostomi Craniata FAM19A2 HGNC:21589 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 Q8N3H0 Cytoplasm. Extracellular (GO:0005576) 15028294 cytoplasm 100 0 cytoplasm. secreted multiple Amniota Euteleostomi Craniata FAM19A3 HGNC:21590 family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 Q7Z5A8 Secreted. Extracellular (GO:0005576) 15028294 secreted 100 0 secreted secreted Human Amniota Craniata FAM19A4 HGNC:21591 family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 Q96LR4 Secreted. Extracellular (GO:0005576) 15028294 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata FAM19A5 HGNC:21592 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 Q7Z5A7 Membrane; Single-pass membrane protein (Potential). Isoform 2: Secreted. Extracellular (GO:0005576) secreted 35 0 secreted secreted Tetrapoda Euteleostomi Craniata FAM200A HGNC:25401 family with sequence similarity 200, member A Q8TCP9 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum 7 1 endoplasmic reticulum endoplasmic reticulum NA NA Eukaryota FAM200B HGNC:27740 family with sequence similarity 200, member B P0CF97 nucleus 10 1 nucleus nucleus NA NA Eukaryota FAM203A HGNC:24161 family with sequence similarity 203, member A Q9BTY7 nucleus 69 0 nucleus nucleus NA NA Eukaryota FAM203B HGNC:32323 family with sequence similarity 203, member B P0CB43 nucleus 67 0 nucleus nucleus NA NA Eukaryota FAM204A HGNC:25794 family with sequence similarity 204, member A Q9H8W3 nucleus 98 0 nucleus nucleus Chordata Chordata Metazoa FAM205A HGNC:41911 family with sequence similarity 205, member A Q6ZU69 Membrane; Single-pass membrane protein (Potential). nucleus 95 2 nucleus nucleus Theria Theria Amniota FAM206A HGNC:1364 family with sequence similarity 206, member A Q9NX38 cytoplasm 48 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota FAM207A HGNC:15811 family with sequence similarity 207, member A Q9NSI2 Nucleolus (GO:0005730) 15635413,11790298 nucleus 98 0 nucleus nucleus Eutheria Bilateria Metazoa FAM208A HGNC:30314 family with sequence similarity 208, member A Q9UK61 Nucleus (GO:0005634) none,17081983 nucleus 92 0 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa FAM208B HGNC:23484 family with sequence similarity 208, member B Q5VWN6 nucleus 92 0 nucleus nucleus Amniota Amniota Euteleostomi FAM209A HGNC:16100 family with sequence similarity 209, member A Q5JX71 Membrane; Single-pass type I membrane protein (Potential). secreted 59 1 secreted secreted Mammalia Mammalia Mammalia FAM209B HGNC:16101 family with sequence similarity 209, member B Q5JX69 Membrane; Single-pass type I membrane protein (Potential). secreted 61 1 secreted secreted Human Human Mammalia FAM20A HGNC:23015 family with sequence similarity 20, member A Q96MK3 Secreted (By similarity). Extracellular (GO:0005576) 12975309 secreted 82 0 secreted secreted Human Tetrapoda Metazoa FAM20B HGNC:23017 family with sequence similarity 20, member B O75063 Golgi apparatus membrane; Single-pass type II membrane protein. Extracellular (GO:0005576) golgi apparatus membrane 100 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Metazoa FAM20C HGNC:22140 family with sequence similarity 20, member C Q8IXL6 Secreted (By similarity). Extracellular (GO:0005576) 15676076 secreted 84 0 secreted secreted Bilateria Bilateria Metazoa FAM210A HGNC:28346 family with sequence similarity 210, member A Q96ND0 Membrane; Single-pass membrane protein (Potential). Mitochondrion (Probable). Plasma membrane (GO:0005886) mitochondrion membrane 28 1 mitochondrion mitochondrion Deuterostomia Bilateria Holozoa FAM210B HGNC:16102 family with sequence similarity 210, member B Q96KR6 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 49 3 mitochondrion membrane mitochondrion membrane Human Eukaryota Eukaryota FAM212A HGNC:32480 family with sequence similarity 212, member A Q96EL1 nucleus 80 0 nucleus nucleus Theria Euteleostomi Euteleostomi FAM212B HGNC:28045 family with sequence similarity 212, member B Q9NTI7 nucleus 84 0 nucleus nucleus Tetrapoda Euteleostomi Craniata FAM213A HGNC:28651 family with sequence similarity 213, member A Q9BRX8 Cytoplasm. cytoplasm 100 9 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota FAM213B HGNC:28390 family with sequence similarity 213, member B Q8TBF2 Cytoplasm, cytosol (By similarity). cytoplasm 86 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota FAM214A HGNC:25609 family with sequence similarity 214, member A Q32MH5 nucleus 55 1 nucleus nucleus Euteleostomi Opisthokonta Eukaryota FAM214B HGNC:25666 family with sequence similarity 214, member B Q7L5A3 Nucleus (GO:0005634) 16381901 nucleus 58 0 nucleus nucleus Theria Euteleostomi Eukaryota FAM216A HGNC:30180 family with sequence similarity 216, member A Q8WUB2 nucleus 38 0 nucleus nucleus Euarchontoglires Eutheria Olfactores FAM216B HGNC:26883 family with sequence similarity 216, member B Q8N7L0 mitochondrion 32 0 mitochondrion mitochondrion Eutheria Eutheria Eutheria FAM217A HGNC:21362 family with sequence similarity 217, member A Q8IXS0 nucleus 78 0 nucleus nucleus Theria Theria Amniota FAM217B HGNC:16170 family with sequence similarity 217, member B Q9NTX9 nucleus 90 0 nucleus nucleus Mammalia Mammalia Euteleostomi FAM218A HGNC:26466 family with sequence similarity 218, member A Q96MZ4 secreted 49 0 secreted secreted NA NA Homo FAM219A HGNC:19920 family with sequence similarity 219, member A Q8IW50 Cytoplasm (GO:0005737) 17081983 nucleus 83 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Bilateria FAM219B HGNC:24695 family with sequence similarity 219, member B Q5XKK7 nucleus 78 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi FAM21A HGNC:23416 family with sequence similarity 21, member A Q641Q2 Early endosome membrane (By similarity). nucleus 9 0 nucleus nucleus Deuterostomia Eukaryota NA FAM21B HGNC:23417 family with sequence similarity 21, member B Q5SNT6 Early endosome membrane (By similarity). nucleus 99 0 nucleus nucleus Deuterostomia Eukaryota Holozoa FAM21C HGNC:23414 family with sequence similarity 21, member C Q9Y4E1 Early endosome membrane. Cell membrane. Note=Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 9 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA FAM220A HGNC:22422 family with sequence similarity 220, member A Q7Z4H9 Nucleus (By similarity). nucleus 32 0 nucleus nucleus Mammalia Mammalia Craniata FAM221A HGNC:27977 family with sequence similarity 221, member A A4D161 plasma membrane 34 0 n/a n/a Deuterostomia Eukaryota Eukaryota FAM221B HGNC:30762 family with sequence similarity 221, member B A6H8Z2 secreted 10 0 secreted secreted Mammalia Eukaryota Eukaryota FAM222A HGNC:25915 family with sequence similarity 222, member A Q5U5X8 nucleus 17 0 nucleus nucleus Euteleostomi Euteleostomi Craniata FAM222B HGNC:25563 family with sequence similarity 222, member B Q8WU58 cytoplasm 9 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata FAM227A HGNC:44197 family with sequence similarity 227, member A F5H4B4 nucleus 61 0 nucleus nucleus NA NA Eukaryota FAM227B HGNC:26543 family with sequence similarity 227, member B Q96M60 nucleus 66 0 nucleus nucleus Mammalia Eukaryota Eukaryota FAM228A HGNC:34418 family with sequence similarity 228, member A Q86W67 nucleus 52 0 nucleus nucleus Human Eutheria Bilateria FAM228B HGNC:24736 family with sequence similarity 228, member B P0C875 nucleus 66 0 nucleus nucleus NA NA Metazoa FAM229A HGNC:44652 family with sequence similarity 229, member A H3BQW9 nucleus 21 0 nucleus nucleus NA NA Amniota FAM229B HGNC:33858 family with sequence similarity 229, member B Q4G0N7 secreted 24 0 secreted secreted Theria Theria NA FAM231A HGNC:49427 family with sequence similarity 231, member A A6NEA5 secreted 23 0 secreted secreted NA NA Boreoeutheria FAM231B HGNC:49506 family with sequence similarity 231, member B A6NCW3 secreted 34 0 secreted secreted NA NA NA FAM231C HGNC:49508 family with sequence similarity 231, member C A6NEA5 secreted 23 0 secreted secreted NA NA NA FAM231D HGNC:49509 family with sequence similarity 231, member D Q6ZW35 secreted 15 0 secreted secreted NA NA Boreoeutheria FAM24A HGNC:23470 family with sequence similarity 24, member A A6NFZ4 Secreted (Potential). secreted 35 1 secreted secreted Euarchontoglires Euarchontoglires Boreoeutheria FAM24B HGNC:23475 family with sequence similarity 24, member B Q8N5W8 Secreted (Potential). secreted 28 1 secreted secreted Human Human Boreoeutheria FAM25A HGNC:23436 family with sequence similarity 25, member A B3EWG3 mitochondrion 17 0 mitochondrion mitochondrion Mammalia Mammalia Eutheria FAM25B HGNC:23584 family with sequence similarity 25, member B B3EWG4 mitochondrion 17 0 mitochondrion mitochondrion Mammalia Mammalia Eutheria FAM25C HGNC:23586 family with sequence similarity 25, member C B3EWG5 mitochondrion 17 0 mitochondrion mitochondrion Mammalia Mammalia NA FAM25E HGNC:23587 family with sequence similarity 25, member E A8MYX2 secreted 48 0 secreted secreted NA NA NA FAM25G HGNC:23590 family with sequence similarity 25, member G B3EWG6 mitochondrion 17 0 mitochondrion mitochondrion Mammalia Mammalia NA FAM26D HGNC:21094 family with sequence similarity 26, member D Q5JW98 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 40 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Amniota Bilateria FAM26E HGNC:21568 family with sequence similarity 26, member E Q8N5C1 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 34 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Chordata Eumetazoa FAM26F HGNC:33391 family with sequence similarity 26, member F Q5R3K3 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 34 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Euteleostomi FAM27A HGNC:19729 family with sequence similarity 27, member A Q5VT28 secreted 36 0 secreted secreted Homininae Homininae Primates FAM27E3 HGNC:28655 family with sequence similarity 27, member E3 Q08E93 nucleus 33 0 nucleus nucleus NA NA Primates FAM27L HGNC:32410 family with sequence similarity 27-like Q8N5T8 secreted 24 0 secreted secreted Homininae Homininae NA FAM32A HGNC:24563 family with sequence similarity 32, member A Q9Y421 Isoform 1: Nucleus. Isoform 2: Nucleus. nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota FAM35A HGNC:28773 family with sequence similarity 35, member A Q86V20 nucleus 41 2 nucleus nucleus NA NA Eumetazoa FAM3A HGNC:13749 family with sequence similarity 3, member A P98173 Secreted (Potential). Extracellular (GO:0005576) secreted 23 0 secreted secreted Euteleostomi Euteleostomi Opisthokonta FAM3B HGNC:1253 family with sequence similarity 3, member B P58499 Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure. Extracellular (GO:0005576); Nucleus (GO:0005634) 12160727,11707072 secreted 100 0 nucleus. secreted multiple Tetrapoda Tetrapoda Opisthokonta FAM3C HGNC:18664 family with sequence similarity 3, member C Q92520 Secreted (By similarity). Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells. Extracellular (GO:0005576) 12160727 secreted 23 0 secreted secreted Euteleostomi Euteleostomi Opisthokonta FAM3D HGNC:18665 family with sequence similarity 3, member D Q96BQ1 Secreted (Potential). Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12160727,12975309,12975309 secreted 19 0 cytoplasm. nucleus. secreted multiple Tetrapoda Chordata Holozoa FAM43A HGNC:26888 family with sequence similarity 43, member A Q8N2R8 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa FAM43B HGNC:31791 family with sequence similarity 43, member B Q6ZT52 cytoplasm 17 0 cytoplasm cytoplasm Mammalia Euteleostomi Bilateria FAM45A HGNC:31793 family with sequence similarity 45, member A Q8TCE6 cytoplasm 23 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota FAM46A HGNC:18345 family with sequence similarity 46, member A Q96IP4 nucleus 54 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa FAM46B HGNC:28273 family with sequence similarity 46, member B Q96A09 nucleus 51 0 nucleus nucleus Theria Theria Holozoa FAM46C HGNC:24712 family with sequence similarity 46, member C Q5VWP2 nucleus 54 0 nucleus nucleus Bilateria Bilateria Eukaryota FAM46D HGNC:28399 family with sequence similarity 46, member D Q8NEK8 nucleus 42 0 nucleus nucleus Theria Euteleostomi Eukaryota FAM47A HGNC:29962 family with sequence similarity 47, member A Q5JRC9 nucleus 17 0 nucleus nucleus Catarrhini Tetrapoda Cell.Organisms FAM47B HGNC:26659 family with sequence similarity 47, member B Q8NA70 nucleus 80 0 nucleus nucleus Catarrhini Tetrapoda Cell.Organisms FAM47C HGNC:25301 family with sequence similarity 47, member C Q5HY64 secreted 30 0 secreted secreted Catarrhini Tetrapoda NA FAM47E HGNC:34343 family with sequence similarity 47, member E Q6ZV65 nucleus 87 0 nucleus nucleus Amniota Chordata Metazoa FAM49A HGNC:25373 family with sequence similarity 49, member A Q9H0Q0 cytoplasm 9 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota FAM49B HGNC:25216 family with sequence similarity 49, member B Q9NUQ9 cytoplasm 9 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota FAM50A HGNC:18786 family with sequence similarity 50, member A Q14320 Nucleus (Potential). Nucleus (GO:0005634) 9339379 nucleus 37 0 nucleus nucleus Bilateria Eukaryota NA FAM50B HGNC:18789 family with sequence similarity 50, member B Q9Y247 nucleus 38 0 nucleus nucleus Human Human Eukaryota FAM53A HGNC:31860 family with sequence similarity 53, member A Q6NSI3 Nucleus (By similarity). Note=Subnuclear distribution (By similarity). nucleus 48 0 nucleus nucleus Tetrapoda Tetrapoda Bilateria FAM53B HGNC:28968 family with sequence similarity 53, member B Q14153 nucleus 25 0 nucleus nucleus Theria Euteleostomi Craniata FAM53C HGNC:1336 family with sequence similarity 53, member C Q9NYF3 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11087669,17081983 nucleus 22 0 cytoplasm. nucleus multiple Theria Euteleostomi Bilateria FAM57A HGNC:29646 family with sequence similarity 57, member A Q8TBR7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12270127 plasma membrane 100 5 plasma membrane plasma membrane Tetrapoda Bilateria Holozoa FAM57B HGNC:25295 family with sequence similarity 57, member B Q71RH2 Isoform 1: Golgi apparatus membrane; Multi- pass membrane protein (By similarity). Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 38 5 plasma membrane plasma membrane Mammalia Bilateria Eukaryota FAM58A HGNC:28434 family with sequence similarity 58, member A Q8N1B3 Nucleus (GO:0005634) nucleus 14 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota FAM60A HGNC:30702 family with sequence similarity 60, member A Q9NP50 Nucleus (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15334068,17081983 nucleus 60 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa FAM63A HGNC:25648 family with sequence similarity 63, member A Q8N5J2 cytoplasm 17 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota FAM63B HGNC:26954 family with sequence similarity 63, member B Q8NBR6 cytoplasm 20 0 cytoplasm cytoplasm Mammalia Opisthokonta Eukaryota FAM64A HGNC:25483 family with sequence similarity 64, member A Q9BSJ6 Nucleus. Nucleus, nucleolus. Note=Partially localizes to the nucleolus. nucleus 100 0 nucleus nucleus Eutheria Euteleostomi Euteleostomi FAM65A HGNC:25836 family with sequence similarity 65, member A Q6ZS17 Cytoplasm (By similarity). Note=Localizes to the podocyte major processes and cell body (By similarity). cytoplasm 76 0 cytoplasm cytoplasm Chordata Chordata Metazoa FAM65B HGNC:13872 family with sequence similarity 65, member B Q9Y4F9 Isoform 1: Mitochondrion. Isoform 2: Cytoplasm, cytoskeleton. Cell projection, filopodium. Note=Detected in cellular filopodia. Integral to membrane (GO:0016021) 9055809 cytoplasm 16 0 cytoplasm. mitochondrion multiple Euteleostomi Bilateria Metazoa FAM65C HGNC:16168 family with sequence similarity 65, member C Q96MK2 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa FAM69A HGNC:32213 family with sequence similarity 69, member A Q5T7M9 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 96 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Metazoa FAM69B HGNC:28290 family with sequence similarity 69, member B Q5VUD6 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). endoplasmic reticulum membrane 86 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Metazoa FAM69C HGNC:31729 family with sequence similarity 69, member C Q0P6D2 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). endoplasmic reticulum membrane 78 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Metazoa FAM71A HGNC:26541 family with sequence similarity 71, member A Q8IYT1 nucleus 55 0 nucleus nucleus Theria Amniota Craniata FAM71B HGNC:28397 family with sequence similarity 71, member B Q8TC56 Nucleus. Note=Cajal body and speckle localization. nucleus 100 0 nucleus nucleus Eutheria Mammalia Craniata FAM71C HGNC:28594 family with sequence similarity 71, member C Q8NEG0 nucleus 59 0 nucleus nucleus Catarrhini Eutheria Olfactores FAM71D HGNC:20101 family with sequence similarity 71, member D Q8N9W8 nucleus 32 0 nucleus nucleus Eutheria Eutheria Amniota FAM71E1 HGNC:25107 family with sequence similarity 71, member E1 Q6IPT2 nucleus 34 0 nucleus nucleus Eutheria Mammalia Amniota FAM71E2 HGNC:25278 family with sequence similarity 71, member E2 Q8N5Q1 cytoplasm 26 0 cytoplasm cytoplasm Theria Theria Amniota FAM71F1 HGNC:30704 family with sequence similarity 71, member F1 Q96KD3 nucleus 12 0 nucleus nucleus Theria Theria Amniota FAM71F2 HGNC:27998 family with sequence similarity 71, member F2 Q6NXP2 nucleus 18 0 nucleus nucleus Eutheria Eutheria Mammalia FAM72A HGNC:24044 family with sequence similarity 72, member A Q5TYM5 Cytoplasm. Mitochondrion. Note=A V5 epitope- tagged construct has been shown to localize to the nucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926). secreted 54 0 cytoplasm. mitochondrion multiple Deuterostomia Deuterostomia NA FAM72B HGNC:24805 family with sequence similarity 72, member B Q86X60 secreted 58 0 secreted secreted Human Human NA FAM72C HGNC:30602 family with sequence similarity 72, member C H0Y354 secreted 74 0 secreted secreted NA NA Opisthokonta FAM72D HGNC:33593 family with sequence similarity 72, member D Q6L9T8 secreted 53 0 secreted secreted Human Human NA FAM73A HGNC:24741 family with sequence similarity 73, member A Q8NAN2 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 65 3 nucleus nucleus Tetrapoda Euteleostomi Holozoa FAM73B HGNC:23621 family with sequence similarity 73, member B Q7L4E1 Membrane; Multi-pass membrane protein (Potential). nucleus 68 3 nucleus nucleus Bilateria Bilateria Opisthokonta FAM76A HGNC:28530 family with sequence similarity 76, member A Q8TAV0 nucleus 70 0 nucleus nucleus Bilateria Bilateria Eukaryota FAM76B HGNC:28492 family with sequence similarity 76, member B Q5HYJ3 Nucleus speckle. nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota FAM78A HGNC:25465 family with sequence similarity 78, member A Q5JUQ0 secreted 10 0 secreted secreted Human Deuterostomia Opisthokonta FAM78B HGNC:13495 family with sequence similarity 78, member B Q5VT40 cytoplasm 3 0 cytoplasm cytoplasm Chordata Chordata Metazoa FAM81A HGNC:28379 family with sequence similarity 81, member A Q8TBF8 cytoplasm 8 0 cytoplasm cytoplasm Amniota Deuterostomia Holozoa FAM81B HGNC:26335 family with sequence similarity 81, member B Q96LP2 cytoplasm 7 0 cytoplasm cytoplasm Human Human Holozoa FAM83A HGNC:28210 family with sequence similarity 83, member A Q86UY5 cytoplasm 21 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata FAM83B HGNC:21357 family with sequence similarity 83, member B Q5T0W9 cytoplasm 30 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms FAM83C HGNC:16121 family with sequence similarity 83, member C Q9BQN1 cytoplasm 25 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata FAM83D HGNC:16122 family with sequence similarity 83, member D Q9H4H8 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Primarily cytoplasmic during interphase, but beginning in prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. Microtubule (GO:0005874) 15561729 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata FAM83E HGNC:25972 family with sequence similarity 83, member E Q2M2I3 cytoplasm 26 0 cytoplasm cytoplasm Mammalia Mammalia Craniata FAM83F HGNC:25148 family with sequence similarity 83, member F Q8NEG4 cytoplasm 28 0 cytoplasm cytoplasm Theria Euteleostomi Craniata FAM83G HGNC:32554 family with sequence similarity 83, member G A6ND36 cytoplasm 29 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata FAM83H HGNC:24797 family with sequence similarity 83, member H Q6ZRV2 Nucleus (GO:0005634) 17081983 cytoplasm 29 1 nucleus nucleus Euteleostomi Euteleostomi NA FAM84A HGNC:20743 family with sequence similarity 84, member A Q96KN4 nucleus 52 0 nucleus nucleus Euteleostomi Euteleostomi Olfactores FAM84B HGNC:24166 family with sequence similarity 84, member B Q96KN1 Plasma membrane (GO:0005886) 12477722 nucleus 48 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria FAM86A HGNC:32221 family with sequence similarity 86, member A Q96G04 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms FAM86B1 HGNC:28268 family with sequence similarity 86, member B1 Q8N7N1 cytoplasm 90 0 cytoplasm cytoplasm Human Human Eukaryota FAM86B2 HGNC:32222 family with sequence similarity 86, member B2 P0C5J1 cytoplasm 90 0 cytoplasm cytoplasm NA NA Eukaryota FAM86C1 HGNC:25561 family with sequence similarity 86, member C1 Q9NVL1 cytoplasm 90 0 cytoplasm cytoplasm Homininae Homininae Euteleostomi FAM89A HGNC:25057 family with sequence similarity 89, member A Q96GI7 nucleus 63 0 nucleus nucleus Theria Bilateria Deuterostomia FAM89B HGNC:16708 family with sequence similarity 89, member B Q8N5H3 Isoform 3: Cytoplasm (By similarity). Isoform 1: Cell surface (By similarity). Cell surface (GO:0009986) 9525630 nucleus 71 0 nucleus nucleus Human Human Bilateria FAM8A1 HGNC:16372 family with sequence similarity 8, member A1 Q9UBU6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 18 3 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms FAM90A1 HGNC:25526 family with sequence similarity 90, member A1 Q86YD7 Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Eutheria Eutheria Eutheria FAM91A1 HGNC:26306 family with sequence similarity 91, member A1 Q658Y4 nucleus 68 0 nucleus nucleus Eukaryota Eukaryota Eukaryota FAM92A1 HGNC:30452 family with sequence similarity 92, member A1 A1XBS5 nucleus 64 0 nucleus nucleus Euteleostomi Bilateria Holozoa FAM92B HGNC:24781 family with sequence similarity 92, member B Q6ZTR7 nucleus 40 0 nucleus nucleus Mammalia Tetrapoda Holozoa FAM96A HGNC:26235 family with sequence similarity 96, member A Q9H5X1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Bilateria Eukaryota FAM96B HGNC:24261 family with sequence similarity 96, member B Q9Y3D0 Nucleus. Cytoplasm, cytoskeleton, spindle. cytoplasm 47 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms FAM98A HGNC:24520 family with sequence similarity 98, member A Q8NCA5 secreted 15 0 secreted secreted Bilateria Bilateria Eukaryota FAM98B HGNC:26773 family with sequence similarity 98, member B Q52LJ0 nucleus 56 1 nucleus nucleus Euteleostomi Eukaryota Eukaryota FAM98C HGNC:27119 family with sequence similarity 98, member C Q17RN3 nucleus 73 0 nucleus nucleus Human Human Holozoa FAM9A HGNC:18403 family with sequence similarity 9, member A Q8IZU1 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 12213195,12213195 nucleus 100 0 nucleus nucleus Human Human Amniota FAM9B HGNC:18404 family with sequence similarity 9, member B Q8IZU0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12213195,12213195 nucleus 100 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Primates FAM9C HGNC:18405 family with sequence similarity 9, member C Q8IZT9 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12213195,12213195 nucleus 100 0 cytoplasm. nucleus multiple Human Human Primates FAN1 HGNC:29170 FANCD2/FANCI-associated nuclease 1 Q9Y2M0 Nucleus. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2. nucleus 100 0 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms FANCA HGNC:3582 Fanconi anemia, complementation group A O15360 Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,15790592,9398857,11050007,10468606,10567393,15082718,12571280,,15790592,9398857,10567393,10468606,15082718,18550849 nucleus 40 2 cytoplasm. nucleus multiple Amniota Euteleostomi Opisthokonta FANCB HGNC:3583 Fanconi anemia, complementation group B Q8NB91 Nucleus. nucleus 100 0 nucleus nucleus Amniota Euteleostomi Metazoa FANCC HGNC:3584 Fanconi anemia, complementation group C Q00597 Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9454773,12649160,15082718,9454773,12649160,15082718 secreted 39 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria FANCD2 HGNC:3585 Fanconi anemia, complementation group D2 Q9BXW9 Nucleus. Note=Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11239454,15671039,15650050,12086603,11239453,12649160,15199141,12447395,15598749 nucleus 100 1 mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota FANCD2OS HGNC:28623 FANCD2 opposite strand Q96PS1 cytoplasm 19 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Craniata FANCE HGNC:3586 Fanconi anemia, complementation group E Q9HB96 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12093742,12649160,15082718 nucleus 100 0 cytoplasm. nucleus multiple Amniota Deuterostomia Eumetazoa FANCF HGNC:3587 Fanconi anemia, complementation group F Q9NPI8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11063725,12649160,15082718,18550849,11063725,12649160,15082718 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Euteleostomi FANCG HGNC:3588 Fanconi anemia, complementation group G O15287 Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 11756225,10468606,10567393,15082718,,11756225,12915460,10468606,10567393,15082718,15367677,,18550849 nucleus 67 0 cytoplasm. endoplasmic reticulum. nucleus multiple NA NA Euteleostomi FANCI HGNC:25568 Fanconi anemia, complementation group I Q9NVI1 Nucleus. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM- associated ultra-fine DNA bridges. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 17460694,15598749 nucleus 100 0 mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota FANCL HGNC:20748 Fanconi anemia, complementation group L Q9NW38 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12973351,18550849,12973351 nucleus 70 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota FANCM HGNC:23168 Fanconi anemia, complementation group M Q8IYD8 Nucleus. Nucleus (GO:0005634) 16116422 nucleus 100 1 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms FANK1 HGNC:23527 fibronectin type III and ankyrin repeat domains 1 Q8TC84 Nucleus. Cytoplasm (By similarity). cytoplasm 19 0 nucleus nucleus Theria Eukaryota Cell.Organisms FAP HGNC:3590 fibroblast activation protein, alpha Q12884 Cell membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Note=Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7911242,10644713 secreted 19 1 cytoplasm. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms FAR1 HGNC:26222 fatty acyl CoA reductase 1 Q8WVX9 Peroxisome membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 18 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms FAR2 HGNC:25531 fatty acyl CoA reductase 2 Q96K12 Peroxisome membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein. Peroxisome (GO:0005777) 15220348 endoplasmic reticulum membrane 11 3 peroxisome peroxisome Eukaryota Cell.Organisms Cell.Organisms FARP1 HGNC:3591 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) Q9Y4F1 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome (By similarity). Cytoplasm, cytosol (By similarity). Cell projection, filopodium (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Recruited to the cell membrane via interaction with CADM1 (By similarity). secreted 23 0 secreted secreted Bilateria Bilateria Eukaryota FARP2 HGNC:16460 FERM, RhoGEF and pleckstrin domain protein 2 O94887 Cytoskeleton (GO:0005856) secreted 24 0 secreted secreted Bilateria Bilateria Eukaryota FARS2 HGNC:21062 phenylalanyl-tRNA synthetase 2, mitochondrial O95363 Mitochondrion matrix (Potential). Mitochondrion (GO:0005739) 10329163 mitochondrion 27 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms FARSA HGNC:3592 phenylalanyl-tRNA synthetase, alpha subunit Q9Y285 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 9177188,11858721 cytoplasm 42 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms FARSB HGNC:17800 phenylalanyl-tRNA synthetase, beta subunit Q9NSD9 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10049785,15635413 cytoplasm 35 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms FAS HGNC:11920 Fas cell surface death receptor P25445 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9360929,14694156,17159908,7510905,17159907 secreted 26 1 cytoplasm. plasma membrane. secreted multiple Amniota Euteleostomi Holozoa FASLG HGNC:11936 Fas ligand (TNF superfamily, member 6) P48023 Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted (By similarity). FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Extracellular (GO:0005576); Intracellular vesicle (None); Unknown membrane (None); Cell surface (GO:0009986) 10630977,7505205,11559749,9427603,16204241,16204241,16204241 secreted 19 1 lysosome. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa FASN HGNC:3594 fatty acid synthase P49327 Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Cytosol (GO:0005829); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12882974,16263121,15598749,17081983 mitochondrion 12 0 cytoplasm. melanosome. mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms FASTK HGNC:24676 Fas-activated serine/threonine kinase Q14296 Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15110758,15110758 nucleus 19 0 mitochondrion. nucleus multiple Eutheria Euteleostomi Bilateria FASTKD1 HGNC:26150 FAST kinase domains 1 Q53R41 nucleus 66 1 nucleus nucleus Euteleostomi Deuterostomia Metazoa FASTKD2 HGNC:29160 FAST kinase domains 2 Q9NYY8 mitochondrion 23 0 mitochondrion mitochondrion Amniota Bilateria Bilateria FASTKD3 HGNC:28758 FAST kinase domains 3 Q14CZ7 nucleus 46 0 nucleus nucleus Tetrapoda Bilateria Eukaryota FASTKD5 HGNC:25790 FAST kinase domains 5 Q7L8L6 nucleus 16 0 nucleus nucleus Euteleostomi Bilateria Bilateria FAT1 HGNC:3595 FAT atypical cadherin 1 Q14517 Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, perinuclear region. Perinuclear region (GO:0048471); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16979624,8586420,16979624,17081983,17081983 plasma membrane 23 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms FAT2 HGNC:3596 FAT atypical cadherin 2 Q9NYQ8 Cell membrane; Single-pass type I membrane protein (Potential). Cell junction. Nucleus. Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. plasma membrane 18 1 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms FAT3 HGNC:23112 FAT atypical cadherin 3 Q8TDW7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 24 1 secreted secreted Bilateria Cell.Organisms Cell.Organisms FAT4 HGNC:23109 FAT atypical cadherin 4 Q6V0I7 Membrane; Single-pass type I membrane protein (Potential). Note=In the kidney, localizes to primary cilia (By similarity). Plasma membrane (GO:0005886) secreted 25 1 secreted secreted Bilateria Cell.Organisms Cell.Organisms FATE1 HGNC:24683 fetal and adult testis expressed 1 Q969F0 Membrane; Single-pass membrane protein (Potential). mitochondrion membrane 12 1 mitochondrion membrane mitochondrion membrane Eutheria Amniota Amniota FAU HGNC:3597 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed P35544 Ribosome (GO:0005840); Nucleolus (GO:0005730) 1326960,15635413 cytoplasm 81 0 nucleus nucleus Eukaryota Cell.Organisms Eukaryota FAXC HGNC:20742 failed axon connections homolog (Drosophila) Q5TGI0 Membrane; Single-pass membrane protein (Potential). cytoplasm 22 1 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms FAXDC2 HGNC:1334 fatty acid hydroxylase domain containing 2 Q96IV6 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 7 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Opisthokonta Cell.Organisms FBF1 HGNC:24674 Fas (TNFRSF6) binding factor 1 Q8TES7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cell junction. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells. Cytoplasm (GO:0005737) 10978533 cytoplasm 7 0 cytoplasm cytoplasm Amniota Deuterostomia Opisthokonta FBL HGNC:3599 fibrillarin P22087 Nucleus, nucleolus. Note=Fibrillar region of the nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) 12490167,11790298,15635413,16514417,15561729,19059367 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms FBLIM1 HGNC:24686 filamin binding LIM protein 1 Q8WUP2 Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers. Actin cytoskeleton (GO:0015629); Extracellular matrix (GO:0005578) 12679033,12679033 secreted 18 0 cytoplasm. secreted multiple Amniota Euteleostomi Eukaryota FBLN1 HGNC:3600 fibulin 1 P23142 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576);Extracellular (GO:0005576) 7534784,8737292,9106159,2269669/9106159 secreted 100 0 secreted secreted Euteleostomi Bilateria Cell.Organisms FBLN2 HGNC:3601 fibulin 2 P98095 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11531782,8737292,7806230 secreted 100 0 secreted secreted Chordata Bilateria Cell.Organisms FBLN5 HGNC:3602 fibulin 5 Q9UBX5 Secreted. Extracellular (GO:0005576) 10428823 secreted 100 0 secreted secreted Chordata Chordata Cell.Organisms FBLN7 HGNC:26740 fibulin 7 Q53RD9 Secreted, extracellular space, extracellular matrix (By similarity). secreted 81 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms FBN1 HGNC:3603 fibrillin 1 P35555 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11108952 secreted 100 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms FBN2 HGNC:3604 fibrillin 2 P35556 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8120105 secreted 100 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms FBN3 HGNC:18794 fibrillin 3 Q75N90 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 14962672 secreted 100 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms FBP1 HGNC:3606 fructose-1,6-bisphosphatase 1 P09467 Cytoplasm (GO:0005737) 9380240 cytoplasm 46 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms FBP2 HGNC:3607 fructose-1,6-bisphosphatase 2 O00757 Cytoplasm (GO:0005737) cytoplasm 46 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms FBRS HGNC:20442 fibrosin Q9HAH7 Extracellular (GO:0005576) 9809749 nucleus 69 0 secreted secreted Mammalia Tetrapoda Bilateria FBRSL1 HGNC:29308 fibrosin-like 1 Q9HCM7 nucleus 81 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria FBXL12 HGNC:13611 F-box and leucine-rich repeat protein 12 Q9NXK8 nucleus 28 0 nucleus nucleus Theria Chordata Eukaryota FBXL13 HGNC:21658 F-box and leucine-rich repeat protein 13 Q8NEE6 cytoplasm 10 0 cytoplasm cytoplasm Eutheria Eukaryota Cell.Organisms FBXL14 HGNC:28624 F-box and leucine-rich repeat protein 14 Q8N1E6 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms FBXL15 HGNC:28155 F-box and leucine-rich repeat protein 15 Q9H469 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms FBXL16 HGNC:14150 F-box and leucine-rich repeat protein 16 Q8N461 Cytoplasm (GO:0005737) cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms FBXL17 HGNC:13615 F-box and leucine-rich repeat protein 17 Q9UF56 cytoplasm 20 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms FBXL18 HGNC:21874 F-box and leucine-rich repeat protein 18 Q96ME1 nucleus 80 1 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa FBXL19 HGNC:25300 F-box and leucine-rich repeat protein 19 Q6PCT2 nucleus 45 0 nucleus nucleus Theria Euteleostomi Opisthokonta FBXL2 HGNC:13598 F-box and leucine-rich repeat protein 2 Q9UKC9 Membrane; Lipid-anchor. Cytoplasm (GO:0005737) 10508920 cytoplasm 73 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms FBXL20 HGNC:24679 F-box and leucine-rich repeat protein 20 Q96IG2 Cytoplasm (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms FBXL21 HGNC:13600 F-box and leucine-rich repeat protein 21 (gene/pseudogene) Q9UKT6 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). nucleus 23 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa FBXL22 HGNC:27537 F-box and leucine-rich repeat protein 22 Q6P050 Cytoplasm, myofibril, sarcomere, Z line. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Euteleostomi FBXL3 HGNC:13599 F-box and leucine-rich repeat protein 3 Q9UKT7 Nucleus. Cytoplasm. Note=Predominantly nuclear. Nucleus (GO:0005634) 10531035 cytoplasm 10 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa FBXL4 HGNC:13601 F-box and leucine-rich repeat protein 4 Q9UKA2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10531037,10531037 cytoplasm 13 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms FBXL5 HGNC:13602 F-box and leucine-rich repeat protein 5 Q9UKA1 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737) 10531037 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Opisthokonta FBXL6 HGNC:13603 F-box and leucine-rich repeat protein 6 Q8N531 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10531037,10531037 nucleus 13 0 cytoplasm. nucleus multiple Mammalia Bilateria NA FBXL7 HGNC:13604 F-box and leucine-rich repeat protein 7 Q9UJT9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Localizes to the centrosome during spindle formation (By similarity). Cytoplasm (GO:0005737) cytoplasm 98 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms FBXL8 HGNC:17875 F-box and leucine-rich repeat protein 8 Q96CD0 Cytoplasm (GO:0005737) 10531037 cytoplasm 39 0 cytoplasm cytoplasm Theria Deuterostomia Eumetazoa FBXO10 HGNC:13589 F-box protein 10 Q9UK96 nucleus 12 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms FBXO11 HGNC:13590 F-box protein 11 Q86XK2 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms FBXO15 HGNC:13617 F-box protein 15 Q8NCQ5 nucleus 30 0 nucleus nucleus Deuterostomia Deuterostomia Eumetazoa FBXO16 HGNC:13618 F-box protein 16 Q8IX29 cytoplasm 54 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Opisthokonta FBXO17 HGNC:18754 F-box protein 17 Q96EF6 cytoplasm 24 0 cytoplasm cytoplasm NA NA NA FBXO18 HGNC:13620 F-box protein, helicase, 18 Q8NFZ0 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11956208,10531037,10531037 nucleus 58 1 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms FBXO2 HGNC:13581 F-box protein 2 Q9UK22 Cytoplasm (By similarity). Microsome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm (GO:0005737) 9857061 cytoplasm 38 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eumetazoa FBXO21 HGNC:13592 F-box protein 21 O94952 nucleus 52 0 nucleus nucleus Amniota Cell.Organisms Cell.Organisms FBXO22 HGNC:13593 F-box protein 22 Q8NEZ5 Cytoplasm, myofibril, sarcomere, Z line (By similarity). cytoplasm 92 0 cytoplasm cytoplasm Amniota Deuterostomia Cell.Organisms FBXO24 HGNC:13595 F-box protein 24 O75426 secreted 31 0 secreted secreted Theria Chordata Eukaryota FBXO25 HGNC:13596 F-box protein 25 Q8TCJ0 Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1. Nucleus (GO:0005634) 16278047 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria FBXO27 HGNC:18753 F-box protein 27 Q8NI29 cytoplasm 30 0 cytoplasm cytoplasm Eutheria Eutheria Eumetazoa FBXO28 HGNC:29046 F-box protein 28 Q9NVF7 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 79 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Bilateria FBXO3 HGNC:13582 F-box protein 3 Q9UK99 Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10531037,10531037 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms FBXO30 HGNC:15600 F-box protein 30 Q8TB52 Cytoplasm (GO:0005737) 12536519 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa FBXO31 HGNC:16510 F-box protein 31 Q5XUX0 nucleus 51 0 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa FBXO32 HGNC:16731 F-box protein 32 Q969P5 Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus. Nucleus (GO:0005634) 11717410 nucleus 53 0 cytoplasm. nucleus multiple Bilateria Bilateria Bilateria FBXO33 HGNC:19833 F-box protein 33 Q7Z6M2 nucleus 73 0 nucleus nucleus Tetrapoda Bilateria Bilateria FBXO34 HGNC:20201 F-box protein 34 Q9NWN3 nucleus 47 0 nucleus nucleus Euarchontoglires Euteleostomi Olfactores FBXO36 HGNC:27020 F-box protein 36 Q8NEA4 nucleus 82 0 nucleus nucleus Theria Deuterostomia Metazoa FBXO38 HGNC:28844 F-box protein 38 Q6PIJ6 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14729953,14729953 nucleus 68 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Bilateria FBXO39 HGNC:28565 F-box protein 39 Q8N4B4 nucleus 85 0 nucleus nucleus Eutheria Deuterostomia Bilateria FBXO4 HGNC:13583 F-box protein 4 Q9UKT5 Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10531035,10531035 cytoplasm 86 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Holozoa FBXO40 HGNC:29816 F-box protein 40 Q9UH90 Cytoplasm (By similarity). Cytoplasm (GO:0005737) ,17928169, cytoplasm 81 0 cytoplasm cytoplasm Amniota Euteleostomi Metazoa FBXO41 HGNC:29409 F-box protein 41 Q8TF61 cytoplasm 24 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Metazoa FBXO42 HGNC:29249 F-box protein 42 Q6P3S6 cytoplasm 12 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms FBXO43 HGNC:28521 F-box protein 43 Q4G163 nucleus 95 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa FBXO44 HGNC:24847 F-box protein 44 Q9H4M3 cytoplasm 69 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa FBXO45 HGNC:29148 F-box protein 45 P0C2W1 Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). secreted 44 0 secreted secreted Bilateria Bilateria Metazoa FBXO46 HGNC:25069 F-box protein 46 Q6PJ61 nucleus 55 0 nucleus nucleus NA NA Olfactores FBXO47 HGNC:31969 F-box protein 47 Q5MNV8 Mitochondrion (GO:0005739) 15723337 nucleus 13 0 mitochondrion mitochondrion Tetrapoda Deuterostomia Metazoa FBXO48 HGNC:33857 F-box protein 48 Q5FWF7 nucleus 28 0 nucleus nucleus Amniota Deuterostomia Opisthokonta FBXO5 HGNC:13584 F-box protein 5 Q9UKT4 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle. Cytoplasm (GO:0005737) nucleus 82 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa FBXO6 HGNC:13585 F-box protein 6 Q9NRD1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa FBXO7 HGNC:13586 F-box protein 7 Q9Y3I1 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10531037,10531037 cytoplasm 19 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota FBXO8 HGNC:13587 F-box protein 8 Q9NRD0 nucleus 36 1 nucleus nucleus Deuterostomia Deuterostomia Eukaryota FBXO9 HGNC:13588 F-box protein 9 Q9UK97 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota FBXW10 HGNC:1211 F-box and WD repeat domain containing 10 Q5XX13 nucleus 7 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms FBXW11 HGNC:13607 F-box and WD repeat domain containing 11 Q9UKB1 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11896578,15561729 cytoplasm 18 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms FBXW12 HGNC:20729 F-box and WD repeat domain containing 12 Q6X9E4 nucleus 36 1 nucleus nucleus Euarchontoglires Eutheria Eumetazoa FBXW2 HGNC:13608 F-box and WD repeat domain containing 2 Q9UKT8 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10531035,10531037 nucleus 10 1 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms FBXW4 HGNC:10847 F-box and WD repeat domain containing 4 P57775 Cytoplasm (GO:0005737) 10405324 nucleus 12 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms FBXW5 HGNC:13613 F-box and WD repeat domain containing 5 Q969U6 Cytoplasm. cytoplasm 100 1 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms FBXW7 HGNC:16712 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase Q969H0 Isoform 1: Nucleus, nucleoplasm. Isoform 2: Cytoplasm. Isoform 4: Nucleus, nucleolus. Nucleus (By similarity). Cytoplasm (GO:0005737);Nucleolus (GO:0005730); Nucleoplasm (GO:0005654);Nucleoplasm (GO:0005654); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15611062/15611062,15611062/15611062,17081983/11461910,11461910 nucleus 18 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms FBXW8 HGNC:13597 F-box and WD repeat domain containing 8 Q8N3Y1 Cytoplasm, perinuclear region. Golgi apparatus. Note=Co-localizes with CUL7 at the Golgi apparatus in neurons (By similarity). nucleus 35 0 cytoplasm. golgi apparatus multiple Tetrapoda Euteleostomi Cell.Organisms FBXW9 HGNC:28136 F-box and WD repeat domain containing 9 Q5XUX1 nucleus 23 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms FCAMR HGNC:24692 Fc receptor, IgA, IgM, high affinity Q8WWV6 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11779189,11779189 plasma membrane 42 1 plasma membrane. secreted multiple Eutheria Mammalia Craniata FCAR HGNC:3608 Fc fragment of IgA, receptor for P24071 Isoform A.1: Cell membrane; Single-pass type I membrane protein. Isoform A.2: Cell membrane; Single-pass type I membrane protein. Isoform A.3: Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted. Isoform B-delta-S2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11929131,18768864,11801662 plasma membrane 21 2 plasma membrane. secreted multiple Catarrhini Eutheria NA FCER1A HGNC:3609 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide P12319 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12646639 plasma membrane 100 1 plasma membrane plasma membrane Theria Theria Eumetazoa FCER1G HGNC:3611 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide P30273 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2138619 plasma membrane 100 1 plasma membrane plasma membrane Theria Amniota Opisthokonta FCER2 HGNC:3612 Fc fragment of IgE, low affinity II, receptor for (CD23) P06734 Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23. Plasma membrane (GO:0005886) 9680363 secreted 21 1 plasma membrane. secreted multiple Theria Bilateria Cell.Organisms FCF1 HGNC:20220 FCF1 rRNA-processing protein Q9Y324 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730) 15635413 nucleus 55 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms FCGBP HGNC:13572 Fc fragment of IgG binding protein Q9Y6R7 Secreted (Probable). Extracellular (GO:0005576) 9182547,1984453 plasma membrane 19 0 secreted secreted Deuterostomia Bilateria Cell.Organisms FCGR1A HGNC:3613 Fc fragment of IgG, high affinity Ia, receptor (CD64) P12314 Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G. Plasma membrane (GO:0005886) 10933786 plasma membrane 100 1 plasma membrane plasma membrane Euteleostomi Euteleostomi NA FCGR1B HGNC:3614 Fc fragment of IgG, high affinity Ib, receptor (CD64) Q92637 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Catarrhini NA FCGR2A HGNC:3616 Fc fragment of IgG, low affinity IIa, receptor (CD32) P12318 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1379234 plasma membrane 100 1 plasma membrane plasma membrane Homininae Euarchontoglires Eumetazoa FCGR2B HGNC:3618 Fc fragment of IgG, low affinity IIb, receptor (CD32) P31994 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9227318 plasma membrane 100 1 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa FCGR2C HGNC:15626 Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) P31995 Isoform IIC4: Cytoplasm (Probable). Isoform IIC3: Cell membrane; Single-pass type I membrane protein. Isoform IIC2: Cell membrane; Single-pass type I membrane protein. Isoform IIC1: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 93 1 cytoplasm. plasma membrane multiple NA NA Eumetazoa FCGR3A HGNC:3619 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) P08637 Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Exists also as a soluble receptor. Plasma membrane (GO:0005886) 7543538 plasma membrane 35 1 plasma membrane. secreted multiple Theria Theria Bilateria FCGR3B HGNC:3620 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) O75015 Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage. plasma membrane 38 1 secreted secreted Theria Theria Bilateria FCGRT HGNC:3621 Fc fragment of IgG, receptor, transporter, alpha P55899 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Endosome (GO:0005768); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 12023961,12023961,12023961,12144784,12006623,12006623,12885906 plasma membrane 59 1 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome. plasma membrane. secreted multiple Theria Theria Craniata FCHO1 HGNC:29002 FCH domain only 1 O14526 Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes. cytoplasm 10 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FCHO2 HGNC:25180 FCH domain only 2 Q0JRZ9 Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 18 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota FCHSD1 HGNC:25463 FCH and double SH3 domains 1 Q86WN1 cytoplasm 34 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Opisthokonta FCHSD2 HGNC:29114 FCH and double SH3 domains 2 O94868 cytoplasm 38 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota FCN1 HGNC:3623 ficolin (collagen/fibrinogen domain containing) 1 O00602 Secreted. Note=Found on the monocyte and granulocyte surface. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9202708,9777405 secreted 100 0 secreted secreted Bilateria Bilateria Metazoa FCN2 HGNC:3624 ficolin (collagen/fibrinogen domain containing lectin) 2 Q15485 Secreted. Extracellular (GO:0005576) 9202708,16188874 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Metazoa FCN3 HGNC:3625 ficolin (collagen/fibrinogen domain containing) 3 O75636 Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct. Extracellular (GO:0005576);Extracellular (GO:0005576) 9694814,16188874/9694814 secreted 100 0 secreted secreted Catarrhini Theria Metazoa FCRL1 HGNC:18509 Fc receptor-like 1 Q96LA6 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11493702 plasma membrane 100 1 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms FCRL2 HGNC:14875 Fc receptor-like 2 Q96LA5 Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11162587,11493702,11162587 plasma membrane 100 1 plasma membrane. secreted multiple Human Tetrapoda Metazoa FCRL3 HGNC:18506 Fc receptor-like 3 Q96P31 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 11493702 plasma membrane 100 1 plasma membrane plasma membrane Homininae Amniota Metazoa FCRL4 HGNC:18507 Fc receptor-like 4 Q96PJ5 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 11290337 plasma membrane 100 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa FCRL5 HGNC:18508 Fc receptor-like 5 Q96RD9 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11290337,11929751,11290337,11929751 plasma membrane 100 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Metazoa FCRL6 HGNC:31910 Fc receptor-like 6 Q6DN72 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 26 1 plasma membrane plasma membrane Eutheria Eutheria Metazoa FCRLA HGNC:18504 Fc receptor-like A Q7L513 Secreted (Probable). Cytoplasm. plasma membrane 25 0 cytoplasm. secreted multiple Eutheria Eutheria Euteleostomi FCRLB HGNC:26431 Fc receptor-like B Q6BAA4 Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted. Plasma membrane (GO:0005886) plasma membrane 29 0 cytoplasm. endoplasmic reticulum multiple Mammalia Mammalia Euteleostomi FDCSP HGNC:19215 follicular dendritic cell secreted protein Q8NFU4 Secreted. Extracellular (GO:0005576) 12193705 secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Primates FDFT1 HGNC:3629 farnesyl-diphosphate farnesyltransferase 1 P37268 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 8068731,7986083,7843406,14718574 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane. secreted multiple Eukaryota Cell.Organisms Cell.Organisms FDPS HGNC:3631 farnesyl diphosphate synthase P14324 Cytoplasm. Peroxisome (GO:0005777) 8188698 cytoplasm 100 2 cytoplasm. peroxisome multiple Eukaryota Cell.Organisms Cell.Organisms FDX1 HGNC:3638 ferredoxin 1 P10109 Mitochondrion matrix. Mitochondrion (GO:0005739) 3339111 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms FDX1L HGNC:30546 ferredoxin 1-like Q6P4F2 Mitochondrion. Mitochondrion matrix (By similarity). mitochondrion membrane 33 0 mitochondrion mitochondrion Eukaryota Cell.Organisms NA FDXACB1 HGNC:25110 ferredoxin-fold anticodon binding domain containing 1 Q9BRP7 mitochondrion 22 1 mitochondrion mitochondrion NA NA NA FDXR HGNC:3642 ferredoxin reductase P22570 Mitochondrion matrix. Mitochondrion (GO:0005739) 12137805,2236061 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms FECH HGNC:3647 ferrochelatase P22830 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 7629135,1184741,15598749 mitochondrion 31 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms FEM1A HGNC:16934 fem-1 homolog a (C. elegans) Q9BSK4 Cytoplasm (Probable). cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms FEM1B HGNC:3649 fem-1 homolog b (C. elegans) Q9UK73 Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin. cytoplasm 18 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms FEM1C HGNC:16933 fem-1 homolog c (C. elegans) Q96JP0 Cytoplasm (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms FEN1 HGNC:3650 flap structure-specific endonuclease 1 P39748 Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Isoform FENMIT: Mitochondrion. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11430825,14688284,15561729,15635413 nucleus 15 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms FER HGNC:3655 fer (fps/fes related) tyrosine kinase P16591 Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1990274,1990274 plasma membrane 30 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms FER1L5 HGNC:19044 fer-1-like 5 (C. elegans) A0AVI2 Cell membrane (By similarity). Membrane; Single-pass membrane protein (Potential). Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity). plasma membrane 20 1 plasma membrane plasma membrane NA NA NA FER1L6 HGNC:28065 fer-1-like 6 (C. elegans) Q2WGJ9 Membrane; Single-pass membrane protein (Potential). secreted 19 1 secreted secreted Bilateria Eukaryota Eukaryota FERD3L HGNC:16660 Fer3-like bHLH transcription factor Q96RJ6 Nucleus (By similarity). nucleus 36 0 nucleus nucleus Amniota Bilateria Metazoa FERMT1 HGNC:15889 fermitin family member 1 Q9BQL6 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles. Cytoplasm (GO:0005737) 12789646 cytoplasm 26 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FERMT2 HGNC:15767 fermitin family member 2 Q96AC1 Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band (By similarity). Cell surface (By similarity). Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/12679033 cytoplasm 24 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota FERMT3 HGNC:23151 fermitin family member 3 Q86UX7 Cell projection, podosome (By similarity). Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12886250,12886250 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FES HGNC:3657 feline sarcoma oncogene P07332 Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 7700650,7523858,7700650,11339827,12543931 plasma membrane 26 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Bilateria Bilateria Cell.Organisms FETUB HGNC:3658 fetuin B Q9UGM5 Secreted (By similarity). Extracellular (GO:0005576) 12943536,16188874 secreted 17 0 secreted secreted Euteleostomi Euteleostomi Craniata FEV HGNC:18562 FEV (ETS oncogene family) Q99581 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Bilateria Metazoa FEZ1 HGNC:3659 fasciculation and elongation protein zeta 1 (zygin I) Q99689 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane (By similarity). Note=Co-localizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9971736,11856312,9971736 nucleus 88 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa FEZ2 HGNC:3660 fasciculation and elongation protein zeta 2 (zygin II) Q9UHY8 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Bilateria Eumetazoa FEZF1 HGNC:22788 FEZ family zinc finger 1 A0PJY2 Nucleus. nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota FEZF2 HGNC:13506 FEZ family zinc finger 2 Q8TBJ5 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 96 0 nucleus nucleus Bilateria Bilateria Eukaryota FFAR1 HGNC:4498 free fatty acid receptor 1 O14842 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12629551,9344866,12565875 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Euteleostomi FFAR2 HGNC:4501 free fatty acid receptor 2 O15552 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9344866 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa FFAR3 HGNC:4499 free fatty acid receptor 3 O14843 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9344866 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa FFAR4 HGNC:19061 free fatty acid receptor 4 Q5NUL3 Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalized with ARRB2 following DHA treatment (By similarity). Integral to membrane (GO:0016021) 14623098 plasma membrane 83 7 plasma membrane plasma membrane Theria Tetrapoda Eumetazoa FGA HGNC:3661 fibrinogen alpha chain P02671 Secreted. Extracellular (GO:0005576) 12430881,6165239,10467729,6575389,10913112,12119191,11739173 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa FGB HGNC:3662 fibrinogen beta chain P02675 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 8910396,9224210,9028318,6165239,10766195,11460528,9787167,2322576,16199891,16188874,11460506 secreted 100 0 endoplasmic reticulum. secreted multiple Euteleostomi Euteleostomi Holozoa FGD1 HGNC:3663 FYVE, RhoGEF and PH domain containing 1 P98174 Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 11181572,11181572,10906777 secreted 13 0 golgi apparatus. secreted multiple Deuterostomia Bilateria Eukaryota FGD2 HGNC:3664 FYVE, RhoGEF and PH domain containing 2 Q7Z6J4 Cytoplasm, cytoskeleton (Probable). Cytoplasm (By similarity). Nucleus (By similarity). Early endosome (By similarity). Early endosome membrane (By similarity). Cell projection, ruffle membrane (By similarity). Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides (By similarity). Cytoplasm (GO:0005737) cytoplasm 13 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota FGD3 HGNC:16027 FYVE, RhoGEF and PH domain containing 3 Q5JSP0 Cytoplasm (Probable). Cytoplasm, cytoskeleton (Probable). cytoplasm 6 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota FGD4 HGNC:19125 FYVE, RhoGEF and PH domain containing 4 Q96M96 Cytoplasm, cytoskeleton (By similarity). Cell projection, filopodium (By similarity). Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). Cytoskeleton (GO:0005856) 9668039 cytoplasm 6 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota FGD5 HGNC:19117 FYVE, RhoGEF and PH domain containing 5 Q6ZNL6 Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F- actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5. cytoplasm 10 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus multiple Euteleostomi Euteleostomi Eukaryota FGD6 HGNC:21740 FYVE, RhoGEF and PH domain containing 6 Q6ZV73 Cytoplasm (Probable). Cytoplasm, cytoskeleton (Probable). cytoplasm 27 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota FGF1 HGNC:3665 fibroblast growth factor 1 (acidic) P05230 Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 10206481,12145206,8679713 secreted 26 0 cytoplasm. nucleus. secreted multiple Tetrapoda Euteleostomi Eumetazoa FGF10 HGNC:3666 fibroblast growth factor 10 O15520 Secreted (Potential). Extracellular (GO:0005576) 11923311 secreted 38 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FGF11 HGNC:3667 fibroblast growth factor 11 Q92914 secreted 24 0 secreted secreted Theria Euteleostomi Eumetazoa FGF12 HGNC:3668 fibroblast growth factor 12 P61328 Nucleus (Probable). Nucleus (GO:0005634) 8790420 secreted 26 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa FGF13 HGNC:3670 fibroblast growth factor 13 Q92913 Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell projection, dendrite (By similarity). Nucleus. Cytoplasm. Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm. Nucleus. secreted 28 0 cytoplasm. nucleus multiple Chordata Chordata Eumetazoa FGF14 HGNC:3671 fibroblast growth factor 14 Q92915 Nucleus (Probable). Nucleus (GO:0005634) 8790420 secreted 25 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa FGF16 HGNC:3672 fibroblast growth factor 16 O43320 Secreted (By similarity). Extracellular (GO:0005576) 11276432 secreted 98 0 secreted secreted Bilateria Bilateria NA FGF17 HGNC:3673 fibroblast growth factor 17 O60258 Secreted. Extracellular (GO:0005576) 9514906 secreted 100 0 secreted secreted Mammalia Euteleostomi Eumetazoa FGF18 HGNC:3674 fibroblast growth factor 18 O76093 Secreted (By similarity). Extracellular (GO:0005576) 9660775 secreted 98 0 secreted secreted Chordata Chordata Eumetazoa FGF19 HGNC:3675 fibroblast growth factor 19 O95750 Secreted. Extracellular (GO:0005576) 11110663 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Chordata FGF2 HGNC:3676 fibroblast growth factor 2 (basic) P09038 Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634) 11276432,11276432,2435575,7735329 nucleus 32 0 nucleus. secreted multiple Tetrapoda Euteleostomi Eumetazoa FGF20 HGNC:3677 fibroblast growth factor 20 Q9NP95 Secreted. Extracellular (GO:0005576) 10913340 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FGF21 HGNC:3678 fibroblast growth factor 21 Q9NSA1 Secreted (Potential). Extracellular (GO:0005576) 12975309 secreted 25 0 secreted secreted Eutheria Euteleostomi Bilateria FGF22 HGNC:3679 fibroblast growth factor 22 Q9HCT0 Secreted (Potential). Extracellular (GO:0005576) 11342227 secreted 32 0 secreted secreted Mammalia Euteleostomi Eumetazoa FGF23 HGNC:3680 fibroblast growth factor 23 Q9GZV9 Secreted. Note=Secretion is dependent on O- glycosylation. Extracellular (GO:0005576) 11032749 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FGF3 HGNC:3681 fibroblast growth factor 3 P11487 Secreted (Potential). Extracellular (GO:0005576) 10749884 secreted 32 1 secreted secreted Euteleostomi Euteleostomi NA FGF4 HGNC:3682 fibroblast growth factor 4 P08620 Secreted (Potential). Extracellular (GO:0005576) 11021964 secreted 47 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FGF5 HGNC:3683 fibroblast growth factor 5 P12034 Secreted (Potential). Extracellular (GO:0005576) 11715949,9333017,2005884 secreted 32 0 secreted secreted Chordata Chordata Eumetazoa FGF6 HGNC:3684 fibroblast growth factor 6 P10767 Secreted, extracellular space. Extracellular (GO:0005576) 10945637 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FGF7 HGNC:3685 fibroblast growth factor 7 P21781 Secreted. Extracellular (GO:0005576) 11821103 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FGF8 HGNC:3686 fibroblast growth factor 8 (androgen-induced) P55075 Secreted. Extracellular matrix (GO:0005578); Cytoplasm (GO:0005737) 11021964,11953856 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Eumetazoa FGF9 HGNC:3687 fibroblast growth factor 9 P31371 Secreted. Extracellular (GO:0005576) 8321227 secreted 100 0 secreted secreted Tetrapoda Chordata Eumetazoa FGFBP1 HGNC:19695 fibroblast growth factor binding protein 1 Q14512 Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10753873,1885605,11291074 secreted 7 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Euteleostomi FGFBP2 HGNC:29451 fibroblast growth factor binding protein 2 Q9BYJ0 Secreted, extracellular space. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11342666,11342666 secreted 100 0 cytoplasm. secreted multiple Catarrhini Euteleostomi Euteleostomi FGFBP3 HGNC:23428 fibroblast growth factor binding protein 3 Q8TAT2 Secreted (Probable). secreted 14 0 secreted secreted Euarchontoglires Euteleostomi Craniata FGFR1 HGNC:3688 fibroblast growth factor receptor 1 P11362 Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8737680,8737680,8737680 plasma membrane 23 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms FGFR1OP HGNC:17012 FGFR1 oncogene partner O95684 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with gamma-tubulin. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota FGFR1OP2 HGNC:23098 FGFR1 oncogene partner 2 Q9NVK5 Cytoplasm (By similarity). cytoplasm 44 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa FGFR2 HGNC:3689 fibroblast growth factor receptor 2 P21802 Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 15229180,15229180,12648559,15229180,1313574 cytoplasm 26 1 cytoplasm. golgi apparatus. nucleus. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms FGFR3 HGNC:3690 fibroblast growth factor receptor 3 P22607 Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor. Extracellular (GO:0005576); Nucleus (GO:0005634);Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023); Perinuclear vesicle (None) 11703096,11703096/8428519,8530501,11329138,8530501,11329138,8530501,8530501,8530501 cytoplasm 26 1 cytoplasm. endoplasmic reticulum. nucleus. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms FGFR4 HGNC:3691 fibroblast growth factor receptor 4 P22455 Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Isoform 2: Secreted. Extracellular (GO:0005576);Plasma membrane (GO:0005886) 11549253/9211733 cytoplasm 24 1 endoplasmic reticulum. endosome. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms FGFRL1 HGNC:3693 fibroblast growth factor receptor-like 1 Q8N441 Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Secretory vesicle (None); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12813049,12813049,12813049,12813049,12813049 secreted 15 1 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Deuterostomia Bilateria Metazoa FGG HGNC:3694 fibrinogen gamma chain P02679 Secreted. Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 6281794,8404605,11986220,2665853,8470043,2990550,1429662 secreted 100 0 golgi apparatus. secreted multiple Chordata Chordata Metazoa FGGY HGNC:25610 FGGY carbohydrate kinase domain containing Q96C11 peroxisome 15 0 peroxisome peroxisome Deuterostomia Cell.Organisms Cell.Organisms FGL1 HGNC:3695 fibrinogen-like 1 Q08830 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 14981537,11470158 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Holozoa FGL2 HGNC:3696 fibrinogen-like 2 Q14314 Secreted. Extracellular (GO:0005576) 9647217 secreted 100 0 secreted secreted Chordata Chordata Holozoa FGR HGNC:3697 feline Gardner-Rasheed sarcoma viral oncogene homolog P09769 Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane (By similarity). Mitochondrion intermembrane space (By similarity). Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. Cytoplasm (GO:0005737) 3023853 plasma membrane 30 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms FH HGNC:3700 fumarate hydratase P07954 Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 434773,15598749,434773 mitochondrion 96 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms FHAD1 HGNC:29408 forkhead-associated (FHA) phosphopeptide binding domain 1 B1AJZ9 cytoplasm 8 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms FHDC1 HGNC:29363 FH2 domain containing 1 Q9C0D6 Cytoskeleton (GO:0005856) secreted 40 0 secreted secreted Deuterostomia Eukaryota Eukaryota FHIT HGNC:3701 fragile histidine triad P49789 Cytoplasm. Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11768238,11768238 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Eukaryota NA FHL1 HGNC:3702 four and a half LIM domains 1 Q13642 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Nucleus. Isoform 2: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes. Cytoplasm (GO:0005737) 10480922 nucleus 35 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota FHL2 HGNC:3703 four and a half LIM domains 2 Q14192 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11821401,11813260,15156572,16343438,15156572,11124707,11813260,16343438,11135358 nucleus 50 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota FHL3 HGNC:3704 four and a half LIM domains 3 Q13643 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 12681290,12681290,15117962,11135358 nucleus 35 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Eukaryota Eukaryota FHL5 HGNC:17371 four and a half LIM domains 5 Q5TD97 Nucleus. Note=Nuclei of round and elongated spermatids. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10086359,11420126,12493914,12493914 nucleus 100 0 cytoplasm. nucleus multiple Theria Amniota Eukaryota FHOD1 HGNC:17905 formin homology 2 domain containing 1 Q9Y613 Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Actin cytoskeleton (GO:0015629) 10352228,15138285,15051728,15642356 cytoplasm 42 2 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FHOD3 HGNC:26178 formin homology 2 domain containing 3 Q2V2M9 Cytoplasm, cytoskeleton. Isoform 4: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FIBCD1 HGNC:25922 fibrinogen C domain containing 1 Q8N539 Membrane; Single-pass type II membrane protein (Potential). secreted 45 1 secreted secreted Bilateria Bilateria Cell.Organisms FIBIN HGNC:33747 fin bud initiation factor homolog (zebrafish) Q8TAL6 Secreted (By similarity). Golgi apparatus (By similarity). Endoplasmic reticulum. cytoplasm 9 0 endoplasmic reticulum endoplasmic reticulum Eutheria Euteleostomi Craniata FIBP HGNC:3705 fibroblast growth factor (acidic) intracellular binding protein O43427 Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783) 9806903,9806903,9806903 nucleus 60 0 endoplasmic reticulum. mitochondrion. nucleus multiple Theria Eukaryota Eukaryota FICD HGNC:18416 FIC domain containing Q9BVA6 Membrane; Single-pass membrane protein (Potential). secreted 24 1 secreted secreted Bilateria Cell.Organisms Cell.Organisms FIG4 HGNC:16873 FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) Q92562 Endosome membrane. Note=Localization requires VAC14 and PIKFYVE. endoplasmic reticulum membrane 16 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota FIGF HGNC:3708 c-fos induced growth factor (vascular endothelial growth factor D) O43915 Secreted. Extracellular (GO:0005576) 9435229,9479493 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FIGLA HGNC:24669 folliculogenesis specific basic helix-loop-helix Q6QHK4 Nucleus (Probable). Nucleus (GO:0005634) 15044608 nucleus 34 0 nucleus nucleus Theria Chordata NA FIGN HGNC:13285 fidgetin Q5HY92 Nucleus matrix (By similarity). nucleus 36 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms FIGNL1 HGNC:13286 fidgetin-like 1 Q6PIW4 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms FILIP1 HGNC:21015 filamin A interacting protein 1 Q7Z7B0 Cytoplasm (GO:0005737) 12055638 cytoplasm 92 0 cytoplasm cytoplasm Chordata Chordata Eukaryota FILIP1L HGNC:24589 filamin A interacting protein 1-like Q4L180 Cytoplasm. Membrane. Nucleus. cytoplasm 34 0 cytoplasm. nucleus multiple Chordata Chordata Opisthokonta FIP1L1 HGNC:19124 factor interacting with PAPOLA and CPSF1 Q6UN15 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms FIS1 HGNC:21689 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) Q9Y3D6 Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Mitochondrion (GO:0005739) 12783892,12861026 mitochondrion membrane 12 1 mitochondrion. mitochondrion membrane. peroxisome membrane multiple Theria Eukaryota Eukaryota FITM1 HGNC:33714 fat storage-inducing transmembrane protein 1 A5D6W6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Euteleostomi Eumetazoa FITM2 HGNC:16135 fat storage-inducing transmembrane protein 2 Q8N6M3 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Opisthokonta Opisthokonta FIZ1 HGNC:25917 FLT3-interacting zinc finger 1 Q96SL8 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10409713,10409713 nucleus 32 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota FJX1 HGNC:17166 four jointed box 1 (Drosophila) Q86VR8 Secreted (By similarity). secreted 88 0 secreted secreted NA NA Eumetazoa FKBP10 HGNC:18169 FK506 binding protein 10, 65 kDa Q96AY3 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) 12036304,11071917,15671042 endoplasmic reticulum 89 0 endoplasmic reticulum endoplasmic reticulum Chordata Cell.Organisms NA FKBP11 HGNC:18624 FK506 binding protein 11, 19 kDa Q9NYL4 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 27 1 cytoplasm cytoplasm Eutheria Euteleostomi Cell.Organisms FKBP14 HGNC:18625 FK506 binding protein 14, 22 kDa Q9NWM8 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 12036304 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Eukaryota Cell.Organisms FKBP15 HGNC:23397 FK506 binding protein 15, 133kDa Q5T1M5 Cytoplasm (By similarity). Cell projection, axon (By similarity). Early endosome. Note=Present in axons and neuronal growth cones (By similarity). Axon (GO:0030424); Actin cytoskeleton (GO:0015629) 16756961,16756961 nucleus 25 0 endosome endosome Deuterostomia Eukaryota Cell.Organisms FKBP1A HGNC:3711 FK506 binding protein 1A, 12kDa P62942 Cytoplasm. Cytoplasm (GO:0005737); Sarcoplasmic reticulum (GO:0016529) 1713687,8524402,1374404 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Cell.Organisms Cell.Organisms FKBP1B HGNC:3712 FK506 binding protein 1B, 12.6 kDa P68106 Cytoplasm (By similarity). Sarcoplasmic reticulum (By similarity). Cytoplasm (GO:0005737) 12443530 cytoplasm 82 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms FKBP2 HGNC:3718 FK506 binding protein 2, 13kDa P26885 Endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Endoplasmic reticulum lumen (GO:0005788); Lysosome (GO:0005764); Mitochondrial membrane (GO:0005740); Membrane fraction (GO:0005624) 8373365,1713687,1713687,9531554 mitochondrion 38 0 endoplasmic reticulum. lysosome. mitochondrion membrane multiple Theria Cell.Organisms Cell.Organisms FKBP3 HGNC:3719 FK506 binding protein 3, 25kDa Q00688 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7689229,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Cell.Organisms Cell.Organisms FKBP4 HGNC:3720 FK506 binding protein 4, 59kDa Q02790 Cytoplasm, cytosol (By similarity). Mitochondrion. Nucleus. Cytoplasm, cytoskeleton (By similarity). Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11751894,11751894 cytoplasm 43 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms FKBP5 HGNC:3721 FK506 binding protein 5 Q13451 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 11751894 cytoplasm 93 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms FKBP6 HGNC:3722 FK506 binding protein 6, 36kDa O75344 cytoplasm 21 0 cytoplasm cytoplasm Chordata Bilateria NA FKBP7 HGNC:3723 FK506 binding protein 7 Q9Y680 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) 9806833 endoplasmic reticulum 84 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Deuterostomia Cell.Organisms FKBP8 HGNC:3724 FK506 binding protein 8, 38kDa Q14318 Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12510191,12510191,15757646 nucleus 19 1 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Bilateria Cell.Organisms FKBP9 HGNC:3725 FK506 binding protein 9, 63 kDa O95302 Endoplasmic reticulum (By similarity). Endoplasmic reticulum (GO:0005783) 10524204 endoplasmic reticulum 91 0 endoplasmic reticulum endoplasmic reticulum Chordata Cell.Organisms Cell.Organisms FKBPL HGNC:13949 FK506 binding protein like Q9UIM3 cytoplasm 18 0 cytoplasm cytoplasm Eutheria Deuterostomia NA FKRP HGNC:17997 fukutin related protein Q9H9S5 Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Cell membrane, sarcolemma (By similarity). Rough endoplasmic reticulum. Note=According to some studies the N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted. Localization at the cell membrane may require the presence of dystroglycan. At the Golgi apparatus localizes to the middle-to- trans-cisternae, as assessed by MG160 colocalization. Detected in rough endoplasmic reticulum in myocytes. In general, mutants associated with severe clinical phenotypes are retained within the endoplasmic reticulum. Golgi apparatus (GO:0005794) 11592034 endoplasmic reticulum membrane 11 1 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms FKTN HGNC:3622 fukutin O75072 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Cytoplasm (GO:0005737); Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 12172906,10734260,9690476,9690476,12471058 secreted 20 0 cytoplasm. golgi apparatus. secreted multiple Euteleostomi Bilateria Cell.Organisms FLAD1 HGNC:24671 flavin adenine dinucleotide synthetase 1 Q8NFF5 cytoplasm 22 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms FLCN HGNC:27310 folliculin Q8NFG4 Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Co-localizes with FNIP1 and FNIP2 in the cytoplasm. Cytoplasm (GO:0005737) 12204536 nucleus 43 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota FLG HGNC:3748 filaggrin P20930 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12230510,12230510 cytoplasm 22 0 cytoplasm. nucleus multiple Homininae Eutheria Mammalia FLG2 HGNC:33276 filaggrin family member 2 Q5D862 Extracellular (GO:0005576) 16188874 cytoplasm 27 0 secreted secreted Mammalia Mammalia Euteleostomi FLI1 HGNC:3749 Fli-1 proto-oncogene, ETS transcription factor Q01543 Nucleus. Nucleus (GO:0005634) 8246959 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa FLII HGNC:3750 flightless I homolog (Drosophila) Q13045 Nucleus (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cell junction, focal adhesion (By similarity). Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11171324,14966289,17081983,11171324,14966289,17081983 secreted 15 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms FLNA HGNC:3754 filamin A, alpha P21333 Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cell projection (GO:0042995); Cytosol (GO:0005829); Mitochondrion (GO:0005739) 2391361,17215244,17081983,11602572,17081983,12198493,12198493,16263121,15561729,15598749 cytoplasm 26 1 cytoplasm. mitochondrion. nucleus. plasma membrane multiple Bilateria Eukaryota NA FLNB HGNC:3755 filamin B, beta O75369 Isoform 1: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm, cytoskeleton. Isoform 6: Cytoplasm, cytoskeleton. Note=Polarized at the periphery of myotubes. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9651345,9651345,8327473 cytoplasm 24 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota FLNC HGNC:3756 filamin C, gamma Q14315 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Cytoplasm (GO:0005737) 12525170 cytoplasm 25 1 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota FLOT1 HGNC:3757 flotillin 1 O75955 Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Melanosome. Endosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886); Kinetochore (GO:0000776) 11167132,15561729 cytoplasm 10 0 endosome. melanosome multiple Theria Cell.Organisms NA FLOT2 HGNC:3758 flotillin 2 Q14254 Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Note=Membrane-associated protein of caveolae. Plasma membrane (GO:0005886) 11159550,10212252 mitochondrion 11 0 endosome endosome Deuterostomia Bilateria Cell.Organisms FLRT1 HGNC:3760 fibronectin leucine rich transmembrane protein 1 Q9NZU1 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 10644439 secreted 21 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms FLRT2 HGNC:3761 fibronectin leucine rich transmembrane protein 2 O43155 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 10644439 secreted 22 1 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms FLRT3 HGNC:3762 fibronectin leucine rich transmembrane protein 3 Q9NZU0 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10644439,17081983 secreted 20 1 cytoplasm. plasma membrane multiple Tetrapoda Euteleostomi Cell.Organisms FLT1 HGNC:3763 fms-related tyrosine kinase 1 P17948 Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Cytoplasm (Potential). Isoform 6: Cytoplasm (Potential). Isoform 7: Cytoplasm (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10579917,10579917,17051153 plasma membrane 31 1 endosome. plasma membrane. secreted multiple Deuterostomia Deuterostomia Cell.Organisms FLT3 HGNC:3765 fms-related tyrosine kinase 3 P36888 Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation. Plasma membrane (GO:0005886) 9651358 plasma membrane 20 1 endoplasmic reticulum. plasma membrane multiple Mammalia Euteleostomi Cell.Organisms FLT3LG HGNC:3766 fms-related tyrosine kinase 3 ligand P49771 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7824267,10637491,9651358,10637491 secreted 97 1 plasma membrane. secreted multiple Eutheria Mammalia Amniota FLT4 HGNC:3767 fms-related tyrosine kinase 4 P35916 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14648657,14648657,16530705 plasma membrane 62 1 cytoplasm. nucleus. plasma membrane. secreted multiple Deuterostomia Deuterostomia Cell.Organisms FLVCR1 HGNC:24682 feline leukemia virus subgroup C cellular receptor 1 Q9Y5Y0 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10400745,10648427,15369674 plasma membrane 49 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms FLVCR2 HGNC:20105 feline leukemia virus subgroup C cellular receptor family, member 2 Q9UPI3 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14729055 plasma membrane 100 12 plasma membrane plasma membrane NA NA Cell.Organisms FLYWCH1 HGNC:25404 FLYWCH-type zinc finger 1 Q4VC44 Nucleus (Probable). secreted 48 0 nucleus nucleus Eutheria Eutheria Eumetazoa FLYWCH2 HGNC:25178 FLYWCH family member 2 Q96CP2 secreted 52 0 secreted secreted Eutheria Eutheria Eutheria FMN1 HGNC:3768 formin 1 Q68DA7 Nucleus (By similarity). Cytoplasm (By similarity). Cell junction, adherens junction (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Localization to the adherens junctions is alpha- catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 14647292,14647292,17081983 nucleus 64 0 cytoplasm. nucleus multiple NA NA Eukaryota FMN2 HGNC:14074 formin 2 Q9NZ56 Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cell cortex (By similarity). Nucleus, nucleolus. Note=Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). nucleus 46 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota FMNL1 HGNC:1212 formin-like 1 O95466 Cytoplasm (By similarity). Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome (By similarity). Isoform 3: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10958683,17081983,10958683 cytoplasm 56 0 cytoplasm cytoplasm Mammalia Tetrapoda Eukaryota FMNL2 HGNC:18267 formin-like 2 Q96PY5 Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 68 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota FMNL3 HGNC:23698 formin-like 3 Q8IVF7 Cytoplasm. Note=Enriched in lamellipodia. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota FMO1 HGNC:3769 flavin containing monooxygenase 1 Q01740 Microsome membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum (GO:0005783) 12642475 cytoplasm 11 1 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms FMO2 HGNC:3770 flavin containing monooxygenase 2 (non-functional) Q99518 Microsome membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum (GO:0005783) 9804831 cytoplasm 12 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms FMO3 HGNC:3771 flavin containing monooxygenase 3 P31513 Microsome membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum (GO:0005783) 7720103 mitochondrion 39 1 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms FMO4 HGNC:3772 flavin containing monooxygenase 4 P31512 Microsome membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum (GO:0005783) 8128486 cytoplasm 13 1 endoplasmic reticulum endoplasmic reticulum Amniota Amniota Cell.Organisms FMO5 HGNC:3773 flavin containing monooxygenase 5 P49326 Microsome membrane. Endoplasmic reticulum membrane. Endoplasmic reticulum (GO:0005783) 12490590,11128045 cytoplasm 12 1 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms FMOD HGNC:3774 fibromodulin Q06828 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11400162 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms FMR1 HGNC:3775 fragile X mental retardation 1 Q06787 Cytoplasm. Nucleus, nucleolus. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983/10567518,7781595,10567518 cytoplasm 68 0 cytoplasm. nucleus multiple Deuterostomia Bilateria NA FMR1NB HGNC:26372 fragile X mental retardation 1 neighbor Q8N0W7 Membrane; Multi-pass membrane protein (Potential). secreted 31 2 n/a n/a Eutheria Eutheria NA FN1 HGNC:3778 fibronectin 1 P02751 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783);Nucleus (GO:0005634) 12180907,16188874,9651579/17081983 secreted 100 0 endoplasmic reticulum. nucleus. secreted multiple Euteleostomi Deuterostomia Cell.Organisms FN3K HGNC:24822 fructosamine 3 kinase Q9H479 mitochondrion 23 0 mitochondrion mitochondrion Human Amniota Cell.Organisms FN3KRP HGNC:25700 fructosamine 3 kinase related protein Q9HA64 mitochondrion 27 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms FNBP1 HGNC:17069 formin binding protein 1 Q96RU3 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11438682,15252009,11438682 cytoplasm 7 0 cytoplasm. lysosome. nucleus multiple Bilateria Eukaryota Eukaryota FNBP1L HGNC:20851 formin binding protein 1-like Q5T0N5 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasmic vesicle (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Microtubule (GO:0005874); Nucleus (GO:0005634) 14654988,17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota FNBP4 HGNC:19752 formin binding protein 4 Q8N3X1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15302935,17081983,17081983 secreted 15 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota FNDC1 HGNC:21184 fibronectin type III domain containing 1 Q4ZHG4 Secreted (Potential). secreted 13 0 secreted secreted Euteleostomi Euteleostomi Metazoa FNDC3A HGNC:20296 fibronectin type III domain containing 3A Q9Y2H6 Golgi apparatus membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 cytoplasm 4 1 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms FNDC3B HGNC:24670 fibronectin type III domain containing 3B Q53EP0 Membrane; Single-pass membrane protein (By similarity). cytoplasm 8 1 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms FNDC4 HGNC:20239 fibronectin type III domain containing 4 Q9H6D8 Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12384288,12384288, plasma membrane 21 3 cytoplasm. endoplasmic reticulum multiple Euteleostomi Euteleostomi Cell.Organisms FNDC5 HGNC:20240 fibronectin type III domain containing 5 Q8NAU1 Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein (By similarity). Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 12384288,12384288,12384288 secreted 19 1 cytoplasm. endoplasmic reticulum. plasma membrane. secreted multiple Amniota Euteleostomi Chordata FNDC7 HGNC:26668 fibronectin type III domain containing 7 Q5VTL7 Secreted (Potential). plasma membrane 6 0 n/a n/a Euteleostomi Euteleostomi Cell.Organisms FNDC8 HGNC:25286 fibronectin type III domain containing 8 Q8TC99 nucleus 35 0 nucleus nucleus Eutheria Eutheria Eutheria FNDC9 HGNC:33547 fibronectin type III domain containing 9 Q8TBE3 Membrane; Single-pass membrane protein (Potential). secreted 13 1 secreted secreted Theria Theria Craniata FNIP1 HGNC:29418 folliculin interacting protein 1 Q8TF40 Cytoplasm. Note=Co-localizes with FLCN in the cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota FNIP2 HGNC:29280 folliculin interacting protein 2 Q9P278 Cytoplasm. Note=Co-localizes with FLCN in the cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota FNTA HGNC:3782 farnesyltransferase, CAAX box, alpha P49354 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8175923,8175923 cytoplasm 40 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms FNTB HGNC:3785 farnesyltransferase, CAAX box, beta P49356 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8175923,8175923 secreted 15 0 cytoplasm. nucleus multiple NA NA Eukaryota FOCAD HGNC:23377 focadhesin Q5VW36 Membrane; Multi-pass membrane protein (Potential). Cell junction, focal adhesion. Note=Colocalizes with VCL in astrocytes. secreted 66 12 n/a n/a Euteleostomi Deuterostomia Eukaryota FOLH1 HGNC:3788 folate hydrolase (prostate-specific membrane antigen) 1 Q04609 Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12712410,14571414,13678295,12949815,8417812,11102961,7882349,9809977 plasma membrane 25 1 cytoplasm. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms FOLH1B HGNC:13636 folate hydrolase 1B Q9HBA9 Cytoplasm (Probable). Cytoplasm (GO:0005737) plasma membrane 27 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms NA FOLR1 HGNC:3791 folate receptor 1 (adult) P15328 Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 2166548,2538429,2166548 secreted 71 1 cytoplasm. plasma membrane. secreted multiple Deuterostomia Deuterostomia Eukaryota FOLR2 HGNC:3793 folate receptor 2 (fetal) P14207 Cell membrane; Lipid-anchor, GPI-anchor. Secreted (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 2166548,2166548 secreted 85 1 cytoplasm. plasma membrane. secreted multiple Deuterostomia Deuterostomia Eukaryota FOLR3 HGNC:3795 folate receptor 3 (gamma) P41439 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9547271,7727426,7727426 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Eukaryota FOLR4 HGNC:32565 folate receptor 4, delta (putative) A6ND01 Secreted (Potential). secreted 51 1 secreted secreted Chordata Chordata Eukaryota FOPNL HGNC:26435 FGFR1OP N-terminal like Q96NB1 Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Note=Localizes to pericentriolar satellites, small (70-100 nm) cytoplasmic granules associated with the centrosome. Cytoplasm (GO:0005737) cytoplasm 22 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota FOS HGNC:3796 FBJ murine osteosarcoma viral oncogene homolog P01100 Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 9443941,10918580,16511568,12127989 nucleus 51 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Euteleostomi Eumetazoa FOSB HGNC:3797 FBJ murine osteosarcoma viral oncogene homolog B P53539 Nucleus. Nucleus (GO:0005634) 1903195 nucleus 100 0 nucleus nucleus Theria Euteleostomi Bilateria FOSL1 HGNC:13718 FOS-like antigen 1 P15407 Nucleus. Nucleus (GO:0005634) 9016559,17205062 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria FOSL2 HGNC:3798 FOS-like antigen 2 P15408 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10816578,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria FOXA1 HGNC:5021 forkhead box A1 P55317 Nucleus. Nucleus (GO:0005634) 8652662,1612587,19059367 nucleus 100 0 nucleus nucleus Theria Deuterostomia Opisthokonta FOXA2 HGNC:5022 forkhead box A2 Q9Y261 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus. Nucleus (GO:0005634) 11875061 nucleus 63 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta FOXA3 HGNC:5023 forkhead box A3 P55318 Nucleus. Nucleus (GO:0005634) 9119385,9632808 nucleus 100 0 nucleus nucleus Theria Euteleostomi Opisthokonta FOXB1 HGNC:3799 forkhead box B1 Q99853 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta FOXB2 HGNC:23315 forkhead box B2 Q5VYV0 Nucleus (Probable). nucleus 88 2 nucleus nucleus Euarchontoglires Theria Opisthokonta FOXC1 HGNC:3800 forkhead box C1 Q12948 Nucleus. Nucleus (GO:0005634) 11782474 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FOXC2 HGNC:3801 forkhead box C2 (MFH-1, mesenchyme forkhead 1) Q99958 Nucleus (Probable). Nucleus (GO:0005634) 11078474 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta FOXD1 HGNC:3802 forkhead box D1 Q16676 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Euteleostomi Opisthokonta FOXD2 HGNC:3803 forkhead box D2 O60548 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 86 0 nucleus nucleus Human Catarrhini Opisthokonta FOXD3 HGNC:3804 forkhead box D3 Q9UJU5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 91 0 nucleus nucleus Eutheria Bilateria Opisthokonta FOXD4 HGNC:3805 forkhead box D4 Q12950 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Homininae Homininae Opisthokonta FOXD4L1 HGNC:18521 forkhead box D4-like 1 Q9NU39 Nucleus (By similarity). nucleus 99 0 nucleus nucleus Euarchontoglires Mammalia Opisthokonta FOXD4L2 HGNC:24813 forkhead box D4-like 2 Q6VB85 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 99 0 nucleus nucleus Homininae Homininae Opisthokonta FOXD4L3 HGNC:18523 forkhead box D4-like 3 Q6VB84 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 99 0 nucleus nucleus Homininae Homininae NA FOXD4L4 HGNC:23762 forkhead box D4-like 4 Q8WXT5 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 99 0 nucleus nucleus Homininae Homininae Opisthokonta FOXD4L5 HGNC:18522 forkhead box D4-like 5 Q5VV16 Nucleus (By similarity). nucleus 99 0 nucleus nucleus Homininae Homininae Opisthokonta FOXD4L6 HGNC:31986 forkhead box D4-like 6 Q3SYB3 Nucleus (By similarity). nucleus 99 0 nucleus nucleus Homininae Homininae Opisthokonta FOXE1 HGNC:3806 forkhead box E1 (thyroid transcription factor 2) O00358 Nucleus (Potential). Nucleus (GO:0005634) 9169137 nucleus 77 1 nucleus nucleus Theria Euteleostomi Opisthokonta FOXE3 HGNC:3808 forkhead box E3 Q13461 Nucleus. Nucleus (GO:0005634) nucleus 100 1 nucleus nucleus Human Theria Opisthokonta FOXF1 HGNC:3809 forkhead box F1 Q12946 Nucleus (Probable). Nucleus (GO:0005634) 9722567 nucleus 55 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta FOXF2 HGNC:3810 forkhead box F2 Q12947 Nucleus. Nucleus (GO:0005634) 9722567 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FOXG1 HGNC:3811 forkhead box G1 P55316 Nucleus. Nucleus (GO:0005634) 7585630,8099441 nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta FOXH1 HGNC:3814 forkhead box H1 O75593 Nucleus. Nucleus (GO:0005634) 9702198 nucleus 100 1 nucleus nucleus Theria Euteleostomi Opisthokonta FOXI1 HGNC:3815 forkhead box I1 Q12951 Nucleus. Nucleus (GO:0005634) 9153225 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FOXI2 HGNC:32448 forkhead box I2 Q6ZQN5 Nucleus (Probable). nucleus 67 0 nucleus nucleus Homininae Eutheria Opisthokonta FOXI3 HGNC:35123 forkhead box I3 A8MTJ6 Nucleus (Probable). nucleus 55 0 nucleus nucleus Eutheria Euteleostomi NA FOXJ1 HGNC:3816 forkhead box J1 Q92949 Nucleus. Nucleus (GO:0005634) 9096351,9073514 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta FOXJ2 HGNC:24818 forkhead box J2 Q9P0K8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10966786,12787665,12787665 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Opisthokonta FOXJ3 HGNC:29178 forkhead box J3 Q9UPW0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta FOXK1 HGNC:23480 forkhead box K1 P85037 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 86 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Eukaryota FOXK2 HGNC:6036 forkhead box K2 Q01167 Nucleus (Probable). Nucleus (GO:0005634) 9065434 nucleus 93 0 nucleus nucleus Euteleostomi Bilateria Eukaryota FOXL1 HGNC:3817 forkhead box L1 Q12952 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta FOXL2 HGNC:1092 forkhead box L2 P58012 Nucleus. Nucleus (GO:0005634) 10702024 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FOXM1 HGNC:3818 forkhead box M1 Q08050 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12183437,12183437 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Opisthokonta FOXN1 HGNC:12765 forkhead box N1 O15353 Nucleus. Nucleus (GO:0005634) 10767081 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi NA FOXN2 HGNC:5281 forkhead box N2 P32314 Nucleus. Nucleus (GO:0005634) 1639393 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FOXN3 HGNC:1928 forkhead box N3 O00409 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta FOXN4 HGNC:21399 forkhead box N4 Q96NZ1 Nucleus (Potential). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta FOXO1 HGNC:3819 forkhead box O1 Q12778 Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11030146,16679294,11030146,12966085,16679294 nucleus 30 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta FOXO3 HGNC:3821 forkhead box O3 O43524 Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10102273,10102273 nucleus 32 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta FOXO4 HGNC:7139 forkhead box O4 P98177 Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9010221,11313479 nucleus 28 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta FOXO6 HGNC:24814 forkhead box O6 A8MYZ6 Cytoplasm (By similarity). Nucleus (By similarity). Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). nucleus 31 0 nucleus nucleus Human Theria Opisthokonta FOXP1 HGNC:3823 forkhead box P1 Q9H334 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11757404,15161711,11757404,15161711 nucleus 29 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta FOXP2 HGNC:13875 forkhead box P2 O15409 Nucleus (Probable). Nucleus (GO:0005634) 10880297 nucleus 26 0 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta FOXP3 HGNC:6106 forkhead box P3 Q9BZS1 Nucleus (Potential). Nucleus (GO:0005634) 11483607,17377532 nucleus 30 0 nucleus nucleus Mammalia Mammalia NA FOXP4 HGNC:20842 forkhead box P4 Q8IVH2 Nucleus (Potential). Nucleus (GO:0005634) 14516685 nucleus 27 0 nucleus nucleus Theria Bilateria Opisthokonta FOXQ1 HGNC:20951 forkhead box Q1 Q9C009 Nucleus (By similarity). nucleus 69 0 nucleus nucleus Homininae Chordata Opisthokonta FOXR1 HGNC:29980 forkhead box R1 Q6PIV2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 19 0 nucleus nucleus Euteleostomi Euteleostomi NA FOXR2 HGNC:30469 forkhead box R2 Q6PJQ5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 15 0 nucleus nucleus Euarchontoglires Euarchontoglires Opisthokonta FOXRED1 HGNC:26927 FAD-dependent oxidoreductase domain containing 1 Q96CU9 Membrane; Single-pass membrane protein (Potential). Mitochondrion (GO:0005739) 16381901,16582907 mitochondrion 10 1 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms FOXRED2 HGNC:26264 FAD-dependent oxidoreductase domain containing 2 Q8IWF2 Endoplasmic reticulum lumen. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Deuterostomia Cell.Organisms FOXS1 HGNC:3735 forkhead box S1 O43638 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 70 0 nucleus nucleus Theria Amniota Opisthokonta FPGS HGNC:3824 folylpolyglutamate synthase Q05932 Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix. Isoform 2: Cytoplasm. Cytosol (GO:0005829);Mitochondrion (GO:0005739) 8662720,7721888/8662720,7721888 mitochondrion 32 1 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms FPGT HGNC:3825 fucose-1-phosphate guanylyltransferase O14772 Cytoplasm. Cytoplasm (GO:0005737) 9804772 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms FPR1 HGNC:3826 formyl peptide receptor 1 P21462 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 6129903,6129903 plasma membrane 100 7 golgi apparatus. plasma membrane multiple Mammalia Mammalia Eumetazoa FPR2 HGNC:3827 formyl peptide receptor 2 P25090 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9054386 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa FPR3 HGNC:3828 formyl peptide receptor 3 P25089 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11285256 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa FRA10AC1 HGNC:1162 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 Q70Z53 Nucleus. Nucleoplasm (GO:0005654) 15203205 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota FRAS1 HGNC:19185 Fraser syndrome 1 Q86XX4 Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential). Extracellular (GO:0005576) 12766770 plasma membrane 19 1 secreted secreted Deuterostomia Eukaryota Cell.Organisms FRAT1 HGNC:3944 frequently rearranged in advanced T-cell lymphomas Q92837 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12095675,12095675 cytoplasm 100 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Euteleostomi FRAT2 HGNC:16048 frequently rearranged in advanced T-cell lymphomas 2 O75474 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12095675,12095675 cytoplasm 81 0 cytoplasm. nucleus multiple Human Human Euteleostomi FREM1 HGNC:23399 FRAS1 related extracellular matrix 1 Q5H8C1 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Note=Localizes at the basement membrane zone of embryonic epidermis and hair follicles (By similarity). secreted 25 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms FREM2 HGNC:25396 FRAS1 related extracellular matrix protein 2 Q5SZK8 Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential). Extracellular (GO:0005576) 15345741 plasma membrane 44 1 secreted secreted Deuterostomia Eukaryota Cell.Organisms FREM3 HGNC:25172 FRAS1 related extracellular matrix 3 P0C091 Secreted, extracellular space, extracellular matrix (By similarity). plasma membrane 38 0 n/a n/a Deuterostomia Eukaryota Cell.Organisms FRG1 HGNC:3954 FSHD region gene 1 Q14331 Nucleus, Cajal body. Nucleus speckle. Nucleus, nucleolus. Note=First expressed in Cajal bodies and nuclear speckles. As speckle expression diminishes, expression is seen in dense structures (dense fibrillar component and the granular component) of the nucleolus. Nucleolus (GO:0005730) 15635413 nucleus 100 0 nucleus nucleus Bilateria Bilateria NA FRG2 HGNC:19136 FSHD region gene 2 Q64ET8 Nucleus. Nucleus (GO:0005634) 15520407 nucleus 100 0 nucleus nucleus Homininae Eutheria NA FRG2B HGNC:33518 FSHD region gene 2 family, member B Q96QU4 Nucleus (By similarity). nucleus 98 0 nucleus nucleus NA NA Eutheria FRG2C HGNC:33626 FSHD region gene 2 family, member C A6NGY1 Nucleus (By similarity). nucleus 92 0 nucleus nucleus Homininae Euarchontoglires Eutheria FRK HGNC:3955 fyn-related kinase P42685 Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery. Nucleus (GO:0005634) 7696183 cytoplasm 33 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms FRMD1 HGNC:21240 FERM domain containing 1 Q8N878 Cytoplasm (GO:0005737) cytoplasm 9 0 cytoplasm cytoplasm Theria Amniota Holozoa FRMD3 HGNC:24125 FERM domain containing 3 A2A2Y4 Membrane; Single-pass membrane protein (Potential). cytoplasm 25 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FRMD4A HGNC:25491 FERM domain containing 4A Q9P2Q2 Cytoplasm, cytoskeleton (By similarity). cytoplasm 43 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota FRMD4B HGNC:24886 FERM domain containing 4B Q9Y2L6 Cytoplasm, cytoskeleton (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11445584,11445584 cytoplasm 92 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota FRMD5 HGNC:28214 FERM domain containing 5 Q7Z6J6 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 26 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota FRMD6 HGNC:19839 FERM domain containing 6 Q96NE9 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Can colocalize with actin. Plasma membrane (GO:0005886) cytoplasm 8 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa FRMD7 HGNC:8079 FERM domain containing 7 Q6ZUT3 Cell projection (By similarity). Cell projection, growth cone (By similarity). Note=In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones (By similarity). secreted 29 0 secreted secreted Amniota Euteleostomi Eukaryota FRMD8 HGNC:25462 FERM domain containing 8 Q9BZ67 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Opisthokonta FRMPD1 HGNC:29159 FERM and PDZ domain containing 1 Q5SYB0 Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found both in the cytoplasm and associated with the cell membrane. nucleus 37 0 cytoplasm cytoplasm Mammalia Deuterostomia Holozoa FRMPD2 HGNC:28572 FERM and PDZ domain containing 2 Q68DX3 Cytoplasm (Potential). Basolateral cell membrane. Cell junction, tight junction. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1. Cytoskeleton (GO:0005856) cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms FRMPD3 HGNC:29382 FERM and PDZ domain containing 3 Q5JV73 nucleus 8 1 nucleus nucleus Tetrapoda Euteleostomi Holozoa FRMPD4 HGNC:29007 FERM and PDZ domain containing 4 Q14CM0 Cell projection, dendritic spine. Cytoplasm (GO:0005737) nucleus 29 0 nucleus nucleus Bilateria Bilateria Holozoa FRRS1 HGNC:27622 ferric-chelate reductase 1 Q6ZNA5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 18 6 n/a n/a Bilateria Bilateria Eukaryota FRRS1L HGNC:1362 ferric-chelate reductase 1-like Q9P0K9 Cell membrane (By similarity). Cell junction, synapse (By similarity). Integral to membrane (GO:0016021) secreted 61 2 n/a n/a Euteleostomi Euteleostomi NA FRS2 HGNC:16971 fibroblast growth factor receptor substrate 2 Q8WU20 Endomembrane system. Note=Cytoplasmic, membrane-bound. Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 12571252,9182757,9660748 nucleus 29 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa FRS3 HGNC:16970 fibroblast growth factor receptor substrate 3 O43559 Membrane; Lipid-anchor. Plasma membrane (GO:0005886) 11877385 cytoplasm 26 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Holozoa FRY HGNC:20367 furry homolog (Drosophila) Q5TBA9 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. cytoplasm 100 9 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota FRYL HGNC:29127 FRY-like O94915 cytoplasm 54 2 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota FRZB HGNC:3959 frizzled-related protein Q92765 Secreted (Probable). Plasma membrane (GO:0005886) 8824257 secreted 42 0 secreted secreted Euteleostomi Deuterostomia Metazoa FSBP HGNC:43653 fibrinogen silencer binding protein O95073 Nucleus. nucleus 100 0 nucleus nucleus NA NA Bilateria FSCB HGNC:20494 fibrous sheath CABYR binding protein Q5H9T9 Cell projection, cilium, flagellum (By similarity). Note=Localizes to cortex of the fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella (By similarity). nucleus 17 0 nucleus nucleus Euarchontoglires Euarchontoglires Mammalia FSCN1 HGNC:11148 fascin actin-bundling protein 1 Q16658 Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 8970159,8579121,7933116,15561729 nucleus 8 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa FSCN2 HGNC:3960 fascin actin-bundling protein 2, retinal O14926 Cytoplasm, cytoskeleton (By similarity). Cell projection, stereocilium (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10892848,18716283 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA FSCN3 HGNC:3961 fascin actin-bundling protein 3, testicular Q9NQT6 Cytoplasm, cytoskeleton (By similarity). Cytoskeleton (GO:0005856) 11925108 cytoplasm 22 0 cytoplasm cytoplasm Mammalia Mammalia Holozoa FSD1 HGNC:13745 fibronectin type III and SPRY domain containing 1 Q9BTV5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Cleavage furrow. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associates with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle. Centrosome (GO:0005813) 12154070 cytoplasm 16 0 cytoplasm. nucleus multiple Chordata Chordata Eumetazoa FSD1L HGNC:13753 fibronectin type III and SPRY domain containing 1-like Q9BXM9 cytoplasm 15 0 cytoplasm cytoplasm Euarchontoglires Euteleostomi Eumetazoa FSD2 HGNC:18024 fibronectin type III and SPRY domain containing 2 A1L4K1 plasma membrane 15 0 n/a n/a Tetrapoda Euteleostomi Eumetazoa FSHB HGNC:3964 follicle stimulating hormone, beta polypeptide P01225 Secreted. Extracellular (GO:0005576) 11502795 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Craniata FSHR HGNC:3969 follicle stimulating hormone receptor P23945 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9408742 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Holozoa FSIP1 HGNC:21674 fibrous sheath interacting protein 1 Q8NA03 cytoplasm 9 0 cytoplasm cytoplasm Eutheria Deuterostomia Bilateria FSIP2 HGNC:21675 fibrous sheath interacting protein 2 Q5CZC0 NA 0 n/a n/a NA NA Metazoa FST HGNC:3971 follistatin P19883 Secreted. Extracellular (GO:0005576) 9799587 secreted 100 0 secreted secreted Euteleostomi Bilateria Eukaryota FSTL1 HGNC:3972 follistatin-like 1 Q12841 Secreted (Potential). Extracellular (GO:0005576) 9786430 secreted 92 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa FSTL3 HGNC:3973 follistatin-like 3 (secreted glycoprotein) O95633 Isoform 1: Secreted. Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to (PubMed:16150905). Extracellular (GO:0005576); Nucleus (GO:0005634) 9671416,11459787 secreted 34 0 nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota FSTL4 HGNC:21389 follistatin-like 4 Q6MZW2 Secreted (Probable). plasma membrane 30 0 secreted secreted Deuterostomia Deuterostomia Eukaryota FSTL5 HGNC:21386 follistatin-like 5 Q8N475 Secreted (Probable). Extracellular (GO:0005576) plasma membrane 20 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms FTCD HGNC:3974 formimidoyltransferase cyclodeaminase O95954 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus (By similarity). Note=More abundantly located around the mother centriole. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9677386,10029623 cytoplasm 51 1 cytoplasm. golgi apparatus multiple Deuterostomia Cell.Organisms Cell.Organisms FTCDNL1 HGNC:48661 formiminotransferase cyclodeaminase N-terminal like E5RQL4 mitochondrion 11 0 mitochondrion mitochondrion NA NA Cell.Organisms FTH1 HGNC:3976 ferritin, heavy polypeptide 1 P02794 Cytoplasm (GO:0005737) 7504084 mitochondrion 75 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms FTHL17 HGNC:3987 ferritin, heavy polypeptide-like 17 Q9BXU8 mitochondrion 55 0 mitochondrion mitochondrion Catarrhini Catarrhini Cell.Organisms FTL HGNC:3999 ferritin, light polypeptide P02792 Cytoplasm (GO:0005737) 7493028,9119260 mitochondrion 43 0 cytoplasm cytoplasm Theria Theria Cell.Organisms FTMT HGNC:17345 ferritin mitochondrial Q8N4E7 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023) 11953424,11323407,12547228,11323407,12406866 mitochondrion 100 0 cytoplasm. mitochondrion multiple Eutheria Eutheria Cell.Organisms FTO HGNC:24678 fat mass and obesity associated Q9C0B1 Nucleus (By similarity). nucleus 84 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota FTSJ1 HGNC:13254 FtsJ RNA methyltransferase homolog 1 (E. coli) Q9UET6 Cytoplasm (By similarity). Nucleolus (GO:0005730) 10648622 cytoplasm 41 0 nucleus nucleus Eukaryota Eukaryota NA FTSJ2 HGNC:16352 FtsJ RNA methyltransferase homolog 2 (E. coli) Q9UI43 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 11827451,11827451 nucleus 100 0 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms FTSJ3 HGNC:17136 FtsJ homolog 3 (E. coli) Q8IY81 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms FUBP1 HGNC:4004 far upstream element (FUSE) binding protein 1 Q96AE4 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12819782,11222755,11071946,17081983,11071946,17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota FUBP3 HGNC:4005 far upstream element (FUSE) binding protein 3 Q96I24 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634) 11071946/17081983 cytoplasm 13 0 nucleus nucleus Chordata Eukaryota Eukaryota FUCA1 HGNC:4006 fucosidase, alpha-L- 1, tissue P04066 Lysosome. Lysosome (GO:0005764); Plasma membrane (GO:0005886) 11389735,11389735 secreted 21 0 lysosome lysosome Bilateria Cell.Organisms Cell.Organisms FUCA2 HGNC:4008 fucosidase, alpha-L- 2, plasma Q9BTY2 Secreted (Probable). Lysosome (GO:0005764) 11389735 secreted 18 0 lysosome. secreted multiple Bilateria Cell.Organisms Cell.Organisms FUK HGNC:29500 fucokinase Q8N0W3 cytoplasm 7 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms FUNDC1 HGNC:28746 FUN14 domain containing 1 Q8IVP5 Mitochondrion outer membrane; Multi-pass membrane protein. mitochondrion membrane 100 4 mitochondrion membrane mitochondrion membrane Euteleostomi Cell.Organisms Cell.Organisms FUNDC2 HGNC:24925 FUN14 domain containing 2 Q9BWH2 Nucleus (GO:0005634) 17081983 mitochondrion membrane 48 0 nucleus nucleus Amniota Amniota NA FUOM HGNC:24733 fucose mutarotase A2VDF0 cytoplasm 41 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms FURIN HGNC:8568 furin (paired basic amino acid cleaving enzyme) P09958 Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 12460941,7508380,7781597 golgi apparatus membrane 47 1 golgi apparatus. golgi apparatus membrane. plasma membrane multiple Bilateria Opisthokonta Cell.Organisms FUS HGNC:4010 fused in sarcoma P35637 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12581738,19059367,9264461,15635413,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Human Mammalia Eukaryota FUT1 HGNC:4012 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) P19526 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 2118655,2118655 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane. secreted multiple Theria Theria Cell.Organisms FUT10 HGNC:19234 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) Q6P4F1 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 11698403 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Tetrapoda Bilateria Cell.Organisms FUT11 HGNC:19233 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) Q495W5 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 27 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Deuterostomia Cell.Organisms FUT2 HGNC:4013 fucosyltransferase 2 (secretor status included) Q10981 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Golgi apparatus (GO:0005794) 11777923 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Mammalia Tetrapoda Cell.Organisms FUT3 HGNC:4014 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) P21217 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 8943285,10394050 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. secreted multiple Bilateria Bilateria Cell.Organisms FUT4 HGNC:4015 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) P22083 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 8116567,8116567,8116567 golgi apparatus membrane 100 1 cytoplasm. golgi apparatus. golgi apparatus membrane. plasma membrane multiple Tetrapoda Bilateria Cell.Organisms FUT5 HGNC:4016 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) Q11128 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Plasma membrane (GO:0005886) 1740457 golgi apparatus membrane 100 1 golgi apparatus membrane. plasma membrane multiple Bilateria Bilateria Cell.Organisms FUT6 HGNC:4017 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) P51993 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 11530205,10536043 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. plasma membrane multiple Bilateria Bilateria Cell.Organisms FUT7 HGNC:4018 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) Q11130 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. Golgi apparatus (GO:0005794) 11825883,8626519 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Human Bilateria Cell.Organisms FUT8 HGNC:4019 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) Q9BYC5 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Note=Membrane-bound form in trans cisternae of Golgi (By similarity). Golgi apparatus (GO:0005794) cytoplasm 17 1 cytoplasm cytoplasm Bilateria Bilateria Holozoa FUT9 HGNC:4020 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) Q9Y231 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Note=Membrane-bound form in trans cisternae of Golgi (By similarity). Golgi apparatus (GO:0005794) 12626397 golgi apparatus membrane 36 1 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Cell.Organisms FUZ HGNC:26219 fuzzy planar cell polarity protein Q9BT04 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). secreted 75 0 secreted secreted Mammalia Bilateria Holozoa FXN HGNC:3951 frataxin Q16595 Cytoplasm. Mitochondrion. Note=PubMed:18725397 reports localization exclusively in mitochondria. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 16091420,9180083,9241270,12354789 mitochondrion 29 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms FXR1 HGNC:4023 fragile X mental retardation, autosomal homolog 1 P51114 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 9259278,10888599,10196376,7781595,10196376,10888599,10888599,9817930 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Holozoa FXR2 HGNC:4024 fragile X mental retardation, autosomal homolog 2 P51116 Cytoplasm. Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleolus (GO:0005730); Nucleus (GO:0005634) 9259278,17081983,8668200,10888599,10196376,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Holozoa FXYD1 HGNC:4025 FXYD domain containing ion transport regulator 1 O00168 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9169143 plasma membrane 30 1 plasma membrane plasma membrane NA NA NA FXYD2 HGNC:4026 FXYD domain containing ion transport regulator 2 P54710 Membrane; Single-pass type III membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11062458,11062458 plasma membrane 9 1 cytoplasm. plasma membrane multiple Mammalia Mammalia Euteleostomi FXYD3 HGNC:4027 FXYD domain containing ion transport regulator 3 Q14802 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 16003754,16003754 plasma membrane 30 1 cytoplasm. plasma membrane multiple Mammalia Euteleostomi Craniata FXYD4 HGNC:4028 FXYD domain containing ion transport regulator 4 P59646 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 36 1 plasma membrane plasma membrane Homininae Homininae Euarchontoglires FXYD5 HGNC:4029 FXYD domain containing ion transport regulator 5 Q96DB9 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11756660 plasma membrane 73 1 plasma membrane plasma membrane Eutheria Eutheria Craniata FXYD6 HGNC:4030 FXYD domain containing ion transport regulator 6 Q9H0Q3 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 33 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata FXYD7 HGNC:4034 FXYD domain containing ion transport regulator 7 P58549 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12093728 plasma membrane 13 1 plasma membrane plasma membrane NA NA Euteleostomi FYB HGNC:4036 FYN binding protein O15117 Cytoplasm. Nucleus (By similarity). secreted 5 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria FYCO1 HGNC:14673 FYVE and coiled-coil domain containing 1 Q9BQS8 Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes. cytoplasm 5 0 endosome. lysosome multiple Deuterostomia Deuterostomia Eukaryota FYN HGNC:4037 FYN oncogene related to SRC, FGR, YES P06241 Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 9060467,16888650,8655574,15561729 cytoplasm 33 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms FYTTD1 HGNC:25407 forty-two-three domain containing 1 Q96QD9 Nucleus, nucleoplasm. Nucleus speckle. nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Craniata FZD1 HGNC:4038 frizzled class receptor 1 Q9UP38 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 12012019 plasma membrane 40 8 plasma membrane plasma membrane Bilateria Bilateria Metazoa FZD10 HGNC:4039 frizzled class receptor 10 Q9ULW2 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9192640 plasma membrane 59 7 plasma membrane plasma membrane Deuterostomia Deuterostomia Metazoa FZD2 HGNC:4040 frizzled class receptor 2 Q14332 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9192640 plasma membrane 38 7 plasma membrane plasma membrane Bilateria Bilateria Metazoa FZD3 HGNC:4041 frizzled class receptor 3 Q9NPG1 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9192640,9192640 plasma membrane 29 7 cytoplasm. plasma membrane multiple Chordata Chordata Metazoa FZD4 HGNC:4042 frizzled class receptor 4 Q9ULV1 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10544037,10544037 plasma membrane 43 7 cytoplasm. plasma membrane multiple Tetrapoda Deuterostomia Metazoa FZD5 HGNC:4043 frizzled class receptor 5 Q13467 Cell membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane and also found at the Golgi (By similarity). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 9192640,11520064 plasma membrane 52 7 golgi apparatus. plasma membrane multiple Bilateria Bilateria Metazoa FZD6 HGNC:4044 frizzled class receptor 6 O60353 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9192640,9192640 plasma membrane 30 7 cytoplasm. plasma membrane multiple Chordata Chordata Metazoa FZD7 HGNC:4045 frizzled class receptor 7 O75084 Membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9192640,9192640 plasma membrane 39 7 cytoplasm. plasma membrane multiple Bilateria Bilateria Metazoa FZD8 HGNC:4046 frizzled class receptor 8 Q9H461 Membrane; Multi-pass membrane protein. Golgi apparatus (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with GOPC at the Golgi apparatus (By similarity). Plasma membrane (GO:0005886) 9192640 plasma membrane 46 7 plasma membrane plasma membrane Bilateria Bilateria Metazoa FZD9 HGNC:4047 frizzled class receptor 9 O00144 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9192640,9192640 plasma membrane 95 7 cytoplasm. plasma membrane multiple Deuterostomia Deuterostomia NA FZR1 HGNC:24824 fizzy/cell division cycle 20 related 1 (Drosophila) Q9UM11 Isoform 2: Nucleus. Isoform 3: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12797865,12560341,12797865 nucleus 36 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms G0S2 HGNC:30229 G0/G1switch 2 P27469 Mitochondrion. mitochondrion 100 1 mitochondrion mitochondrion Homininae Amniota Euteleostomi G2E3 HGNC:20338 G2/M-phase specific E3 ubiquitin protein ligase Q7L622 Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage. Nucleoplasm (GO:0005654); Nucleolus (GO:0005730) 17239372,17239372 nucleus 33 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota G3BP1 HGNC:30292 GTPase activating protein (SH3 domain) binding protein 1 Q13283 Cytoplasm. Cytoplasm, cytosol. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. Cytosol (GO:0005829); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8649363,11888885,17081983,9632780,15743820,11888885,17081983 cytoplasm 58 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms G3BP2 HGNC:30291 GTPase activating protein (SH3 domain) binding protein 2 Q9UN86 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/10969074 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms G6PC HGNC:4056 glucose-6-phosphatase, catalytic subunit P35575 Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 8640227,12189168 endoplasmic reticulum membrane 100 9 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Bilateria Eumetazoa G6PC2 HGNC:28906 glucose-6-phosphatase, catalytic, 2 Q9NQR9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11297555,15044018 endoplasmic reticulum membrane 100 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Bilateria NA G6PC3 HGNC:24861 glucose 6 phosphatase, catalytic, 3 Q9BUM1 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783) 12965222,12965222 endoplasmic reticulum membrane 100 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Mammalia Euteleostomi Cell.Organisms G6PD HGNC:4057 glucose-6-phosphate dehydrogenase P11413 Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11440553,11440553 cytoplasm 43 0 cytoplasm. endoplasmic reticulum multiple Eutheria Cell.Organisms NA GAA HGNC:4065 glucosidase, alpha; acid P10253 Lysosome. Lysosome membrane. Lysosome (GO:0005764) 11973631 plasma membrane 31 1 lysosome lysosome Opisthokonta Cell.Organisms Cell.Organisms GAB1 HGNC:4066 GRB2-associated binding protein 1 Q13480 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10022866,11278704 cytoplasm 52 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota GAB2 HGNC:14458 GRB2-associated binding protein 2 Q9UQC2 Cytoplasm. Cell membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11971018,11971018 cytoplasm 49 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota GAB3 HGNC:17515 GRB2-associated binding protein 3 Q8WWW8 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA GAB4 HGNC:18325 GRB2-associated binding protein family, member 4 Q2WGN9 cytoplasm 18 0 cytoplasm cytoplasm Homininae Homininae Eukaryota GABARAP HGNC:4067 GABA(A) receptor-associated protein O95166 Endomembrane system (By similarity). Cytoplasm, cytoskeleton (By similarity). Golgi apparatus membrane (By similarity). Cytoplasmic vesicle, autophagosome. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10900017,11461150,11146101,11146101,11461150 cytoplasm 17 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Eukaryota GABARAPL1 HGNC:4068 GABA(A) receptor-associated protein like 1 Q9H0R8 Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor. Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome. cytoplasm 21 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota GABARAPL2 HGNC:13291 GABA(A) receptor-associated protein-like 2 P60520 Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome. Golgi apparatus (GO:0005794) 10747018 cytoplasm 25 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota GABBR1 HGNC:4070 gamma-aminobutyric acid (GABA) B receptor, 1 Q9UBS5 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Isoform 1E: Secreted (Probable). Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9753614,16724110/9753614,17081983 secreted 20 7 nucleus. plasma membrane. secreted multiple Bilateria Bilateria NA GABBR2 HGNC:4507 gamma-aminobutyric acid (GABA) B receptor, 2 O75899 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Plasma membrane (GO:0005886) 10328880,16724110 plasma membrane 9 7 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota GABPA HGNC:4071 GA binding protein transcription factor, alpha subunit 60kDa Q06546 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14985350,9887101,14985350,9887101,9016666 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa GABPB1 HGNC:4074 GA binding protein transcription factor, beta subunit 1 Q06547 Nucleus. Nucleus (GO:0005634) 9016666 nucleus 100 0 nucleus nucleus Tetrapoda Cell.Organisms Cell.Organisms GABPB2 HGNC:28441 GA binding protein transcription factor, beta subunit 2 Q8TAK5 Nucleus (By similarity). nucleus 63 0 nucleus nucleus Theria Euteleostomi Cell.Organisms GABRA1 HGNC:4075 gamma-aminobutyric acid (GABA) A receptor, alpha 1 P14867 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Perinuclear region (GO:0048471) 10512150,15198677 plasma membrane 5 4 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms GABRA2 HGNC:4076 gamma-aminobutyric acid (GABA) A receptor, alpha 2 P47869 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. plasma membrane 3 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GABRA3 HGNC:4077 gamma-aminobutyric acid (GABA) A receptor, alpha 3 P34903 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9655866 plasma membrane 6 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GABRA4 HGNC:4078 gamma-aminobutyric acid (GABA) A receptor, alpha 4 P48169 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 7 4 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms GABRA5 HGNC:4079 gamma-aminobutyric acid (GABA) A receptor, alpha 5 P31644 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1321750 plasma membrane 6 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GABRA6 HGNC:4080 gamma-aminobutyric acid (GABA) A receptor, alpha 6 Q16445 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8632757 plasma membrane 5 4 plasma membrane plasma membrane Chordata Chordata Cell.Organisms GABRB1 HGNC:4081 gamma-aminobutyric acid (GABA) A receptor, beta 1 P18505 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 7 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GABRB2 HGNC:4082 gamma-aminobutyric acid (GABA) A receptor, beta 2 P47870 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021);Integral to membrane (GO:0016021) /8264558 plasma membrane 6 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GABRB3 HGNC:4083 gamma-aminobutyric acid (GABA) A receptor, beta 3 P28472 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface (GO:0009986); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Integral to membrane (GO:0016021) 15198677,15198677,15198677,15198677,15198677, plasma membrane 7 4 cytoplasm. endoplasmic reticulum. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms GABRD HGNC:4084 gamma-aminobutyric acid (GABA) A receptor, delta O14764 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2176788 plasma membrane 7 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GABRE HGNC:4085 gamma-aminobutyric acid (GABA) A receptor, epsilon P78334 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) secreted 5 4 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms GABRG1 HGNC:4086 gamma-aminobutyric acid (GABA) A receptor, gamma 1 Q8N1C3 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 10 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms GABRG2 HGNC:4087 gamma-aminobutyric acid (GABA) A receptor, gamma 2 P18507 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737) 11326274,15198677,15198677 secreted 7 4 cytoplasm. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms GABRG3 HGNC:4088 gamma-aminobutyric acid (GABA) A receptor, gamma 3 Q99928 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. plasma membrane 4 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms GABRP HGNC:4089 gamma-aminobutyric acid (GABA) A receptor, pi O00591 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 5 4 plasma membrane plasma membrane Chordata Chordata Cell.Organisms GABRQ HGNC:14454 gamma-aminobutyric acid (GABA) A receptor, theta Q9UN88 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10449790 plasma membrane 5 4 plasma membrane plasma membrane Human Eutheria Cell.Organisms GABRR1 HGNC:4090 gamma-aminobutyric acid (GABA) A receptor, rho 1 P24046 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1849271,10779366 plasma membrane 4 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GABRR2 HGNC:4091 gamma-aminobutyric acid (GABA) A receptor, rho 2 P28476 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12660236 plasma membrane 1 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GABRR3 HGNC:17969 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) A8MPY1 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 5 4 plasma membrane plasma membrane Human Chordata Cell.Organisms GAD1 HGNC:4092 glutamate decarboxylase 1 (brain, 67kDa) Q99259 Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 15147202,7836456,8464926,1321158,7836456 cytoplasm 42 0 cytoplasm. golgi apparatus multiple Bilateria Cell.Organisms Cell.Organisms GAD2 HGNC:4093 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) Q05329 Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. Integral to membrane (GO:0016021) 15147202,8243826 cytoplasm 44 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GADD45A HGNC:4095 growth arrest and DNA-damage-inducible, alpha P24522 Nucleus. Nucleus (GO:0005634) 7478594 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa GADD45B HGNC:4096 growth arrest and DNA-damage-inducible, beta O75293 Nucleus (GO:0005634) 8700517 nucleus 47 0 nucleus nucleus Euteleostomi Bilateria Bilateria GADD45G HGNC:4097 growth arrest and DNA-damage-inducible, gamma O95257 Nucleus (GO:0005634) 12716909 nucleus 48 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa GADD45GIP1 HGNC:29996 growth arrest and DNA-damage-inducible, gamma interacting protein 1 Q8TAE8 Mitochondrion. Nucleus. Note=Using N- terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12716909,15459248,15598749 nucleus 45 0 mitochondrion. nucleus multiple Theria Bilateria Bilateria GADL1 HGNC:27949 glutamate decarboxylase-like 1 Q6ZQY3 nucleus 38 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms GAGE1 HGNC:4098 G antigen 1 Q13065 nucleus 41 1 nucleus nucleus Catarrhini Catarrhini NA GAGE10 HGNC:30968 G antigen 10 A6NGK3 nucleus 48 0 nucleus nucleus Catarrhini Catarrhini NA GAGE12B HGNC:26779 G antigen 12B A1L429 nucleus 41 0 nucleus nucleus NA NA NA GAGE12C HGNC:28402 G antigen 12C A1L429 nucleus 41 0 nucleus nucleus NA NA NA GAGE12D HGNC:31904 G antigen 12D A1L429 nucleus 41 0 nucleus nucleus NA NA NA GAGE12E HGNC:31905 G antigen 12E A1L429 nucleus 41 0 nucleus nucleus Catarrhini Catarrhini NA GAGE12F HGNC:31906 G antigen 12F P0CL80 nucleus 42 0 nucleus nucleus NA NA NA GAGE12G HGNC:31907 G antigen 12G P0CL81 nucleus 42 0 nucleus nucleus Catarrhini Catarrhini NA GAGE12H HGNC:31908 G antigen 12H A6NDE8 nucleus 46 0 nucleus nucleus NA NA NA GAGE12I HGNC:4105 G antigen 12I P0CL82 nucleus 42 0 nucleus nucleus NA NA Primates GAGE12J HGNC:17778 G antigen 12J A6NER3 nucleus 24 0 nucleus nucleus NA NA NA GAGE13 HGNC:29081 G antigen 13 Q4V321 nucleus 40 0 nucleus nucleus NA NA Primates GAGE2A HGNC:4099 G antigen 2A Q6NT46 nucleus 39 0 nucleus nucleus NA NA NA GAGE2B HGNC:31957 G antigen 2B Q13066 nucleus 46 0 nucleus nucleus NA NA Primates GAGE2C HGNC:31958 G antigen 2C Q13066 nucleus 46 0 nucleus nucleus NA NA Primates GAGE2D HGNC:31959 G antigen 2D Q9UEU5 nucleus 46 0 nucleus nucleus NA NA Primates GAGE2E HGNC:31960 G antigen 2E Q4V326 nucleus 44 0 nucleus nucleus Catarrhini Catarrhini Primates GAGE3 HGNC:4100 G antigen 3 Q13067 nucleus 45 0 nucleus nucleus NA NA NA GAGE4 HGNC:4101 G antigen 4 Q13068 nucleus 45 0 nucleus nucleus NA NA NA GAGE5 HGNC:4102 G antigen 5 Q13069 nucleus 42 0 nucleus nucleus NA NA NA GAGE6 HGNC:4103 G antigen 6 Q13070 nucleus 42 0 nucleus nucleus NA NA NA GAGE7 HGNC:4104 G antigen 7 O76087 nucleus 42 0 nucleus nucleus NA NA NA GAK HGNC:4113 cyclin G associated kinase O14976 Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion (Probable). Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10625686,10625686,10625686,9299234 nucleus 26 2 cytoplasm. endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms GAL HGNC:4114 galanin/GMAP prepropeptide P22466 Secreted. Secretory granule (GO:0030141); Extracellular (GO:0005576); Nucleus (GO:0005634) 12814355,1711463,11279301,12106297 secreted 100 0 nucleus. secreted multiple Tetrapoda Tetrapoda Euteleostomi GAL3ST1 HGNC:24240 galactose-3-O-sulfotransferase 1 Q99999 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 5562350,911873,6280086,6955451,4710574 secreted 46 0 endoplasmic reticulum. golgi apparatus multiple Deuterostomia Deuterostomia Holozoa GAL3ST2 HGNC:24869 galactose-3-O-sulfotransferase 2 Q9H3Q3 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) 11029462 secreted 81 0 golgi apparatus membrane golgi apparatus membrane Chordata Chordata Holozoa GAL3ST3 HGNC:24144 galactose-3-O-sulfotransferase 3 Q96A11 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Golgi apparatus (GO:0005794) 11323440 secreted 65 0 golgi apparatus. golgi apparatus membrane multiple Mammalia Euteleostomi Holozoa GAL3ST4 HGNC:24145 galactose-3-O-sulfotransferase 4 Q96RP7 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021) 11333265 secreted 32 0 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi Holozoa GALC HGNC:4115 galactosylceramidase P54803 Lysosome. Lysosome (GO:0005764) 7601472,8297359 cytoplasm 35 0 lysosome lysosome Deuterostomia Bilateria Cell.Organisms GALE HGNC:4116 UDP-galactose-4-epimerase Q14376 cytoplasm 52 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GALK1 HGNC:4118 galactokinase 1 P51570 Cytoplasm (GO:0005737) 8908517 secreted 17 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms GALK2 HGNC:4119 galactokinase 2 Q01415 Cytoplasm (GO:0005737) 8798585 secreted 18 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms GALM HGNC:24063 galactose mutarotase (aldose 1-epimerase) Q96C23 Cytoplasm (Probable). Cytoplasm (GO:0005737) 15026423 secreted 33 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms GALNS HGNC:4122 galactosamine (N-acetyl)-6-sulfate sulfatase P34059 Lysosome. Lysosome (GO:0005764) 7575473 secreted 22 0 lysosome lysosome Deuterostomia Deuterostomia Cell.Organisms GALNT1 HGNC:4123 polypeptide N-acetylgalactosaminyltransferase 1 Q10472 Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Polypeptide N- acetylgalactosaminyltransferase 1 soluble form: Secreted. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 2681181,2681181 golgi apparatus membrane 45 1 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. secreted multiple Bilateria Bilateria Cell.Organisms GALNT10 HGNC:19873 polypeptide N-acetylgalactosaminyltransferase 10 Q86SR1 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 36 1 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms GALNT11 HGNC:19875 :polypeptide N-acetylgalactosaminyltransferase 11 Q8NCW6 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 11925450 golgi apparatus membrane 32 1 golgi apparatus golgi apparatus Bilateria Bilateria Cell.Organisms GALNT12 HGNC:19877 polypeptide N-acetylgalactosaminyltransferase 12 Q8IXK2 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 38 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms GALNT13 HGNC:23242 polypeptide N-acetylgalactosaminyltransferase 13 Q8IUC8 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 46 1 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms GALNT14 HGNC:22946 polypeptide N-acetylgalactosaminyltransferase 14 Q96FL9 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 37 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms GALNT15 HGNC:21531 polypeptide N-acetylgalactosaminyltransferase 15 Q8N3T1 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 30 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Euteleostomi Cell.Organisms GALNT16 HGNC:23233 polypeptide N-acetylgalactosaminyltransferase 16 Q8N428 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 32 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms GALNT18 HGNC:30488 polypeptide N-acetylgalactosaminyltransferase 18 Q6P9A2 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 27 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms GALNT2 HGNC:4124 polypeptide N-acetylgalactosaminyltransferase 2 Q10471 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists. Golgi apparatus (GO:0005794) 12754287 golgi apparatus membrane 32 1 golgi apparatus. golgi apparatus membrane. secreted multiple Bilateria Bilateria Cell.Organisms GALNT3 HGNC:4125 polypeptide N-acetylgalactosaminyltransferase 3 Q14435 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Resides preferentially in the trans and medial parts of the Golgi stack. Golgi apparatus (GO:0005794) 12506059 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Chordata Chordata Cell.Organisms GALNT4 HGNC:4126 polypeptide N-acetylgalactosaminyltransferase 4 Q8N4A0 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Golgi apparatus (GO:0005794) 9804815 golgi apparatus membrane 41 0 golgi apparatus. golgi apparatus membrane multiple NA NA Cell.Organisms GALNT5 HGNC:4127 polypeptide N-acetylgalactosaminyltransferase 5 Q7Z7M9 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 34 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms GALNT6 HGNC:4128 polypeptide N-acetylgalactosaminyltransferase 6 Q8NCL4 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 12506059 golgi apparatus membrane 56 1 golgi apparatus golgi apparatus Chordata Chordata Cell.Organisms GALNT7 HGNC:4129 polypeptide N-acetylgalactosaminyltransferase 7 Q86SF2 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 24 1 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms GALNT8 HGNC:4130 polypeptide N-acetylgalactosaminyltransferase 8 Q9NY28 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 10767557 golgi apparatus membrane 32 1 plasma membrane plasma membrane Catarrhini Euteleostomi Cell.Organisms GALNT9 HGNC:4131 polypeptide N-acetylgalactosaminyltransferase 9 Q9HCQ5 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 27 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi NA GALNTL5 HGNC:21725 polypeptide N-acetylgalactosaminyltransferase-like 5 Q7Z4T8 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 30 1 golgi apparatus membrane golgi apparatus membrane Euarchontoglires Eutheria Cell.Organisms GALNTL6 HGNC:33844 polypeptide N-acetylgalactosaminyltransferase-like 6 Q49A17 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 24 1 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms GALP HGNC:24840 galanin-like peptide Q9UBC7 Secreted. secreted 100 0 secreted secreted Euarchontoglires Eutheria Eutheria GALR1 HGNC:4132 galanin receptor 1 P47211 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7534460 plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Bilateria Metazoa GALR2 HGNC:4133 galanin receptor 2 O43603 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9832121 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa GALR3 HGNC:4134 galanin receptor 3 O60755 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Metazoa GALT HGNC:4135 galactose-1-phosphate uridylyltransferase P07902 cytoplasm 48 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms GAMT HGNC:4136 guanidinoacetate N-methyltransferase Q14353 cytoplasm 37 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms GAN HGNC:4137 gigaxonin Q9H2C0 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11062483,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi NA GANAB HGNC:4138 glucosidase, alpha; neutral AB Q14697 Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Centrosome (GO:0005813) 10929008,15561729 endoplasmic reticulum 30 0 endoplasmic reticulum. melanosome multiple Cell.Organisms Cell.Organisms Cell.Organisms GANC HGNC:4139 glucosidase, alpha; neutral C Q8TET4 Cytoplasm (GO:0005737); Microsome (GO:0005792) 1352226,1352226 endoplasmic reticulum 28 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GAP43 HGNC:4140 growth associated protein 43 P17677 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. Cytoplasm (GO:0005737) 12805215 mitochondrion 28 0 cytoplasm cytoplasm Theria Euteleostomi Euteleostomi GAPDH HGNC:4141 glyceraldehyde-3-phosphate dehydrogenase P04406 Cytoplasm, cytosol. Nucleus (By similarity). Cytoplasm, perinuclear region. Membrane. Cytoplasm, cytoskeleton (By similarity). Note=Translocates to the nucleus following S- nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Extracellular (GO:0005576); Mitochondrion (GO:0005739); Mitochondrion (GO:0005739) 12829261,12842090,17027006,15951807,17081983,12842090,15951807,15635413,16188874,15561729,15598749 cytoplasm 72 0 cytoplasm. mitochondrion. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms GAPDHS HGNC:24864 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic O14556 Cytoplasm (By similarity). Cell projection (GO:0042995) 10714828 cytoplasm 64 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GAPT HGNC:26588 GRB2-binding adaptor protein, transmembrane Q8N292 Cell membrane; Single-pass membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Theria Theria Mammalia GAPVD1 HGNC:23375 GTPase activating protein and VPS9 domains 1 Q14C86 Membrane; Peripheral membrane protein. Endosome. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin. cytoplasm 13 0 endosome endosome Bilateria Bilateria Eukaryota GAR1 HGNC:14264 GAR1 ribonucleoprotein Q9NY12 Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 11074001,11790298,15635413,11074001 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota GAREM HGNC:26136 GRB2 associated, regulator of MAPK1 Q9H706 Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Chordata Chordata Eumetazoa GAREML HGNC:27172 GRB2 associated, regulator of MAPK1-like Q75VX8 secreted 24 0 secreted secreted Human Human Eumetazoa GARNL3 HGNC:25425 GTPase activating Rap/RanGAP domain-like 3 Q5VVW2 nucleus 28 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota GARS HGNC:4162 glycyl-tRNA synthetase P41250 Cytoplasm. Mitochondrion. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 7961834/9524218,15452148,15598749 cytoplasm 38 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms GART HGNC:4163 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase P22102 Cytosol (GO:0005829) 8299947 mitochondrion 39 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA GAS1 HGNC:4165 growth arrest-specific 1 P54826 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10996315,10996315 secreted 98 2 endoplasmic reticulum. plasma membrane multiple Theria Euteleostomi Eumetazoa GAS2 HGNC:4167 growth arrest-specific 2 O43903 Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). Cytoskeleton (GO:0005856); Actin filament (GO:0005884) 9521882,1607387 cytoplasm 51 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GAS2L1 HGNC:16955 growth arrest-specific 2 like 1 Q99501 Cytoplasm, cytoskeleton (Probable). Actin filament (GO:0005884); Microtubule (GO:0005874); Cytoplasm (GO:0005737);Nucleus (GO:0005634);Actin filament (GO:0005884); Cytoplasm (GO:0005737) 12584248,12584248,12584248/17081983/12584248,12584248 nucleus 22 0 cytoplasm. nucleus multiple Theria Bilateria Holozoa GAS2L2 HGNC:24846 growth arrest-specific 2 like 2 Q8NHY3 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737) 12584248 cytoplasm 27 0 cytoplasm cytoplasm Tetrapoda Tetrapoda NA GAS2L3 HGNC:27475 growth arrest-specific 2 like 3 Q86XJ1 Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to microtubule and actin cytoskeletons. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota GAS6 HGNC:4168 growth arrest-specific 6 Q14393 Secreted. Extracellular (GO:0005576) 8637702 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms GAS7 HGNC:4169 growth arrest-specific 7 O60861 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 9736752 cytoplasm 96 0 cytoplasm cytoplasm Theria Chordata Eukaryota GAS8 HGNC:4166 growth arrest-specific 8 O95995 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, flagellum basal body (By similarity). Golgi apparatus (By similarity). Note=Associates with microtubules (By similarity). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity). Cytoplasm (GO:0005737) 11751847 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GAST HGNC:4164 gastrin P01350 Secreted. Extracellular (GO:0005576) 14660571 secreted 100 0 secreted secreted Tetrapoda Tetrapoda NA GATA1 HGNC:4170 GATA binding protein 1 (globin transcription factor 1) P15976 Nucleus. Nucleus (GO:0005634) 11867225,17167422 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda NA GATA2 HGNC:4171 GATA binding protein 2 P23769 Nucleus. Nucleus (GO:0005634) 11567998,11787775 nucleus 100 0 nucleus nucleus Chordata Chordata Eukaryota GATA3 HGNC:4172 GATA binding protein 3 P23771 Nucleus. Nucleus (GO:0005634) 8088776 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota GATA4 HGNC:4173 GATA binding protein 4 P43694 Nucleus. Nucleus (GO:0005634) 7721094 nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Eukaryota GATA5 HGNC:15802 GATA binding protein 5 Q9BWX5 Nucleus (By similarity). Nucleus (GO:0005634) 14715527 nucleus 71 0 nucleus nucleus Amniota Euteleostomi NA GATA6 HGNC:4174 GATA binding protein 6 Q92908 Nucleus. Nucleus (GO:0005634) 10851229 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota GATAD1 HGNC:29941 GATA zinc finger domain containing 1 Q8WUU5 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa GATAD2A HGNC:29989 GATA zinc finger domain containing 2A Q86YP4 Nucleus speckle. Note=Speckled nuclear localization requires both CR1 and CR2 regions. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12183469,16415179,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa GATAD2B HGNC:30778 GATA zinc finger domain containing 2B Q8WXI9 Nucleus speckle. Note=Speckled nuclear localization requires both CR1 and CR2 regions. Nucleus (GO:0005634) 12183469,16415179 nucleus 100 0 nucleus nucleus Human Human NA GATC HGNC:25068 glutamyl-tRNA(Gln) amidotransferase, subunit C O43716 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms GATM HGNC:4175 glycine amidinotransferase (L-arginine:glycine amidinotransferase) P50440 Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Isoform 2: Cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 9148748,9148748 mitochondrion 31 0 cytoplasm. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms GATSL1 HGNC:37072 GATS protein-like 1 A6NNH0 mitochondrion 13 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Cell.Organisms GATSL2 HGNC:37073 GATS protein-like 2 A6NHX0 mitochondrion 16 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Cell.Organisms GATSL3 HGNC:34423 GATS protein-like 3 Q8WTX7 cytoplasm 10 0 cytoplasm cytoplasm NA NA Cell.Organisms GBA HGNC:4177 glucosidase, beta, acid P04062 Lysosome membrane; Peripheral membrane protein; Lumenal side. Note=Interaction with saposin-C promotes membrane association. Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2. Lysosome (GO:0005764); Endosome (GO:0005768); Vesicle (None) 14757764,14757764,14757764 secreted 10 0 endosome. lysosome multiple Bilateria Cell.Organisms NA GBA2 HGNC:18986 glucosidase, beta (bile acid) 2 Q9HCG7 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Not localized to lipid rafts. Microsome (GO:0005792) 11489889,9111029 cytoplasm 38 1 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GBA3 HGNC:19069 glucosidase, beta, acid 3 (gene/pseudogene) Q9H227 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 11043382,11389701 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms GBAS HGNC:4179 glioblastoma amplified sequence O75323 Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 9615231,15598749 cytoplasm 10 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms GBE1 HGNC:4180 glucan (1,4-alpha-), branching enzyme 1 Q04446 mitochondrion 45 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GBF1 HGNC:4181 golgi brefeldin A resistant guanine nucleotide exchange factor 1 Q92538 Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10402461,10402461,17081983,17081983 cytoplasm 23 1 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Cell.Organisms GBGT1 HGNC:20460 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Q8N5D6 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 31 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Euteleostomi Cell.Organisms GBP1 HGNC:4182 guanylate binding protein 1, interferon-inducible P32455 Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12414522,8830800,12543931,12488461 endoplasmic reticulum membrane 23 2 cytoplasm. secreted multiple Tetrapoda Eukaryota Eukaryota GBP2 HGNC:4183 guanylate binding protein 2, interferon-inducible P32456 Cytoplasm. Nucleus. Golgi apparatus membrane; Lipid-anchor. Cytoplasm (GO:0005737) 11096456 nucleus 20 2 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota GBP3 HGNC:4184 guanylate binding protein 3 Q9H0R5 Cytoplasm. Membrane (Potential). Cytoplasm (GO:0005737) 9659399 cytoplasm 15 2 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota GBP4 HGNC:20480 guanylate binding protein 4 Q96PP9 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 9659399 nucleus 28 2 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota GBP5 HGNC:19895 guanylate binding protein 5 Q96PP8 Cytoplasm. Membrane; Lipid-anchor. endoplasmic reticulum membrane 10 2 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota GBP6 HGNC:25395 guanylate binding protein family, member 6 Q6ZN66 endoplasmic reticulum membrane 14 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Eukaryota Eukaryota GBP7 HGNC:29606 guanylate binding protein 7 Q8N8V2 Membrane (Potential). cytoplasm 9 2 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota GBX1 HGNC:4185 gastrulation brain homeobox 1 Q14549 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Euteleostomi Bilateria Eukaryota GBX2 HGNC:4186 gastrulation brain homeobox 2 P52951 Nucleus (Probable). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Tetrapoda Bilateria Eukaryota GC HGNC:4187 group-specific component (vitamin D binding protein) P02774 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Endosome (GO:0005768); Plasma membrane (GO:0005886) 7026425,16188874,7026425,1374401,3552627 secreted 100 0 cytoplasm. endosome. secreted multiple Tetrapoda Euteleostomi Bilateria GCA HGNC:15990 grancalcin, EF-hand calcium binding protein P28676 Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1737748,1737748,11717497 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota GCAT HGNC:4188 glycine C-acetyltransferase O75600 Mitochondrion (By similarity). Nucleus. Note=Translocates to the nucleus upon cold and osmotic stress. Mitochondrion (GO:0005739) 10712613 mitochondrion 19 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms GCC1 HGNC:19095 GRIP and coiled-coil domain containing 1 Q96CN9 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794) 10209125 cytoplasm 27 0 cytoplasm. golgi apparatus multiple Deuterostomia Bilateria Holozoa GCC2 HGNC:23218 GRIP and coiled-coil domain containing 2 Q8IWJ2 Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794);Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12446665/15654769,15522892,15522892,15522892 cytoplasm 37 0 cytoplasm. golgi apparatus multiple Tetrapoda Bilateria Eukaryota GCDH HGNC:4189 glutaryl-CoA dehydrogenase Q92947 Mitochondrion matrix. Mitochondrion (GO:0005739) 3081514,7490088,8541831 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms GCFC2 HGNC:1317 GC-rich sequence DNA-binding factor 2 P16383 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10480038,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eukaryota GCG HGNC:4191 glucagon P01275 Secreted. Extracellular (GO:0005576) 14988249,14719035 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata GCGR HGNC:4192 glucagon receptor P47871 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 6303843 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa GCH1 HGNC:4193 GTP cyclohydrolase 1 P30793 Cytoplasm. Nucleus. cytoplasm 29 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms GCHFR HGNC:4194 GTP cyclohydrolase I feedback regulator P30047 Nucleus. Nucleus membrane. Cytoplasm, cytosol. cytoplasm 34 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa GCK HGNC:4195 glucokinase (hexokinase 4) P35557 Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Secretory granule (GO:0030141) 8549853,9000692,12101177,9000692,12101177 mitochondrion membrane 23 0 cytoplasm. mitochondrion. nucleus multiple Mammalia Opisthokonta Cell.Organisms GCKR HGNC:4196 glucokinase (hexokinase 4) regulator Q14397 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10588736,16186382 cytoplasm 74 1 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms GCLC HGNC:4311 glutamate-cysteine ligase, catalytic subunit P48506 nucleus 26 1 nucleus nucleus Eukaryota Eukaryota Eukaryota GCLM HGNC:4312 glutamate-cysteine ligase, modifier subunit P48507 cytoplasm 15 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Cell.Organisms GCM1 HGNC:4197 glial cells missing homolog 1 (Drosophila) Q9NP62 Nucleus (Potential). Nucleus (GO:0005634) 8962155 nucleus 43 0 nucleus nucleus Tetrapoda Tetrapoda Eumetazoa GCM2 HGNC:4198 glial cells missing homolog 2 (Drosophila) O75603 Nucleus (By similarity). Nucleus (GO:0005634) 10343099 nucleus 42 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta GCN1L1 HGNC:4199 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) Q92616 Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,11790298,17081983 cytoplasm 9 4 nucleus nucleus Eukaryota Eukaryota Cell.Organisms GCNT1 HGNC:4203 glucosaminyl (N-acetyl) transferase 1, core 2 Q02742 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 9278427,12765965 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Tetrapoda Bilateria Cell.Organisms GCNT2 HGNC:4204 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) Q06430 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021) 9134435,8449405 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Tetrapoda Eukaryota Cell.Organisms GCNT3 HGNC:4205 glucosaminyl (N-acetyl) transferase 3, mucin type O95395 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 45 1 golgi apparatus membrane golgi apparatus membrane Chordata Bilateria Cell.Organisms GCNT4 HGNC:17973 glucosaminyl (N-acetyl) transferase 4, core 2 Q9P109 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 32 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms GCNT6 HGNC:21623 glucosaminyl (N-acetyl) transferase 6 Q5T4J0 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 36 1 golgi apparatus membrane golgi apparatus membrane Human Human Cell.Organisms GCNT7 HGNC:16099 glucosaminyl (N-acetyl) transferase family member 7 Q6ZNI0 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 35 0 golgi apparatus membrane golgi apparatus membrane Amniota Euteleostomi Cell.Organisms GCSAM HGNC:20253 germinal center-associated, signaling and motility Q8N6F7 Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. Cytoplasm (GO:0005737) 12509382 cytoplasm 76 0 cytoplasm cytoplasm Eutheria Eutheria Mammalia GCSAML HGNC:29583 germinal center-associated, signaling and motility-like Q5JQS6 cytoplasm 70 0 cytoplasm cytoplasm Catarrhini Theria Mammalia GCSH HGNC:4208 glycine cleavage system protein H (aminomethyl carrier) P23434 Mitochondrion. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 6111451,14718574 mitochondrion 100 0 mitochondrion. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms GDA HGNC:4212 guanine deaminase Q9Y2T3 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10595517,10595517 cytoplasm 31 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GDAP1 HGNC:15968 ganglioside induced differentiation associated protein 1 Q8TB36 Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm (By similarity). Plasma membrane (GO:0005886) 11743580 cytoplasm 41 3 mitochondrion membrane. plasma membrane multiple Amniota Eukaryota Cell.Organisms GDAP1L1 HGNC:4213 ganglioside induced differentiation associated protein 1-like 1 Q96MZ0 Integral to membrane (GO:0016021) cytoplasm 44 3 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms GDAP2 HGNC:18010 ganglioside induced differentiation associated protein 2 Q9NXN4 nucleus 18 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms GDE1 HGNC:29644 glycerophosphodiester phosphodiesterase 1 Q9NZC3 Cytoplasm (By similarity). Membrane; Multi- pass membrane protein (By similarity). Note=Perinuclear vesicles and cell membrane (By similarity). Plasma membrane (GO:0005886) 10760272 cytoplasm 30 2 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms GDF1 HGNC:4214 growth differentiation factor 1 P27539 Secreted. Extracellular (GO:0005576) 1704486 secreted 100 0 secreted secreted Human Theria Metazoa GDF10 HGNC:4215 growth differentiation factor 10 P55107 Secreted. Extracellular (GO:0005576) 8679252 secreted 100 0 secreted secreted Tetrapoda Euteleostomi NA GDF11 HGNC:4216 growth differentiation factor 11 O95390 Secreted (Probable). secreted 58 0 secreted secreted Euteleostomi Bilateria Metazoa GDF15 HGNC:30142 growth differentiation factor 15 Q99988 Secreted (Probable). Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11134143,9326641,10811612,10811612,10811612 secreted 20 0 endoplasmic reticulum. golgi apparatus. secreted multiple Amniota Euteleostomi Metazoa GDF2 HGNC:4217 growth differentiation factor 2 Q9UK05 Secreted. Extracellular (GO:0005576) 10849432 secreted 100 0 secreted secreted Tetrapoda Tetrapoda NA GDF3 HGNC:4218 growth differentiation factor 3 Q9NR23 Secreted (Probable). Extracellular (GO:0005576) 8429021 secreted 30 0 secreted secreted Euteleostomi Euteleostomi Metazoa GDF5 HGNC:4220 growth differentiation factor 5 P43026 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9057810,12543931,17081983,17081983 secreted 100 0 cytoplasm. nucleus. secreted multiple Tetrapoda Euteleostomi Metazoa GDF6 HGNC:4221 growth differentiation factor 6 Q6KF10 Secreted (Probable). Extracellular (GO:0005576) 9057810 secreted 39 0 secreted secreted Euteleostomi Euteleostomi Metazoa GDF7 HGNC:4222 growth differentiation factor 7 Q7Z4P5 Secreted (By similarity). Extracellular (GO:0005576) secreted 29 0 secreted secreted Euarchontoglires Euarchontoglires Metazoa GDF9 HGNC:4224 growth differentiation factor 9 O60383 Secreted (By similarity). Extracellular (GO:0005576) 12135884,8429021 secreted 18 0 secreted secreted Euteleostomi Euteleostomi Metazoa GDI1 HGNC:4226 GDP dissociation inhibitor 1 P31150 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12198156 cytoplasm 98 0 cytoplasm cytoplasm Eukaryota Eukaryota NA GDI2 HGNC:4227 GDP dissociation inhibitor 2 P50395 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Centrosome (GO:0005813) 7929030,7929030,7929030,8575461 cytoplasm 84 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Eukaryota GDNF HGNC:4232 glial cell derived neurotrophic factor P39905 Secreted. Extracellular (GO:0005576) 11588183 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata GDPD1 HGNC:20883 glycerophosphodiester phosphodiesterase domain containing 1 Q8N9F7 Cytoplasm. Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 13 2 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms GDPD2 HGNC:25974 glycerophosphodiester phosphodiesterase domain containing 2 Q9HCC8 Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with the actin cytoskeleton (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12933806,12933806 mitochondrion membrane 24 6 cytoplasm. plasma membrane multiple Theria Euteleostomi Cell.Organisms GDPD3 HGNC:28638 glycerophosphodiester phosphodiesterase domain containing 3 Q7L5L3 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 10 4 mitochondrion membrane mitochondrion membrane Mammalia Euteleostomi Cell.Organisms GDPD4 HGNC:24849 glycerophosphodiester phosphodiesterase domain containing 4 Q6W3E5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 29 5 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms GDPD5 HGNC:28804 glycerophosphodiester phosphodiesterase domain containing 5 Q8WTR4 Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Cell projection, growth cone (By similarity). Note=In a punctate perinuclear pattern (By similarity). plasma membrane 58 6 plasma membrane plasma membrane Tetrapoda Deuterostomia Cell.Organisms GDPGP1 HGNC:34360 GDP-D-glucose phosphorylase 1 Q6ZNW5 Cytoplasm (By similarity). cytoplasm 15 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms GEM HGNC:4234 GTP binding protein overexpressed in skeletal muscle P55040 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7912851,11395774 cytoplasm 16 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Cell.Organisms GEMIN2 HGNC:10884 gem (nuclear organelle) associated protein 2 O14893 Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9323129,10909848,9323129,10909848 nucleus 38 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota GEMIN4 HGNC:15717 gem (nuclear organelle) associated protein 4 P57678 Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829) 10725331,10725331,10725331,15561729 secreted 40 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Bilateria GEMIN5 HGNC:20043 gem (nuclear organelle) associated protein 5 Q8TEQ6 Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11714716,17081983,11714716 cytoplasm 10 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms GEMIN6 HGNC:20044 gem (nuclear organelle) associated protein 6 Q8WXD5 Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11748230,11748230 nucleus 11 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta GEMIN7 HGNC:20045 gem (nuclear organelle) associated protein 7 Q9H840 Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12065586,12065586 nucleus 14 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa GEMIN8 HGNC:26044 gem (nuclear organelle) associated protein 8 Q9NWZ8 Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. nucleus 36 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa GEN1 HGNC:26881 GEN1 Holliday junction 5' flap endonuclease Q17RS7 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 23 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms GET4 HGNC:21690 golgi to ER traffic protein 4 homolog (S. cerevisiae) Q7L5D6 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm NA NA Eukaryota GFAP HGNC:4235 glial fibrillary acidic protein P14136 Cytoplasm. Note=Associated with intermediate filaments. Cytoplasm (GO:0005737) 12084347 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Holozoa GFER HGNC:4236 growth factor, augmenter of liver regeneration P55789 Isoform 1: Mitochondrion intermembrane space. Isoform 2: Cytoplasm. Secreted. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 10384986,9813496,11709497,11709497,10982794 mitochondrion 34 0 cytoplasm. nucleus. secreted multiple Eukaryota Eukaryota Cell.Organisms GFI1 HGNC:4237 growth factor independent 1 transcription repressor Q99684 Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots. Nucleus (GO:0005634) 8754800,12874834,11060035 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota GFI1B HGNC:4238 growth factor independent 1B transcription repressor Q5VTD9 Nucleus. Nucleus (GO:0005634) none,17081983 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota GFM1 HGNC:13780 G elongation factor, mitochondrial 1 Q96RP9 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11735030,15598749 mitochondrion 98 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GFM2 HGNC:29682 G elongation factor, mitochondrial 2 Q969S9 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11735030 mitochondrion 27 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GFOD1 HGNC:21096 glucose-fructose oxidoreductase domain containing 1 Q9NXC2 Secreted (Potential). secreted 55 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms GFOD2 HGNC:28159 glucose-fructose oxidoreductase domain containing 2 Q3B7J2 Secreted, extracellular space, extracellular matrix (By similarity). Nucleus (GO:0005634) 17081983 secreted 94 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms GFPT1 HGNC:4241 glutamine--fructose-6-phosphate transaminase 1 Q06210 Cytoplasm (GO:0005737) 2037571 mitochondrion 20 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GFPT2 HGNC:4242 glutamine-fructose-6-phosphate transaminase 2 O94808 Cytoplasm (GO:0005737) mitochondrion 20 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GFRA1 HGNC:4243 GDNF family receptor alpha 1 P56159 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10774729,11360200,11360200 secreted 97 1 cytoplasm. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Bilateria GFRA2 HGNC:4244 GDNF family receptor alpha 2 O00451 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9192898,10774729,9192898 secreted 99 0 secreted secreted Euteleostomi Euteleostomi Bilateria GFRA3 HGNC:4245 GDNF family receptor alpha 3 O60609 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 9490034 secreted 99 1 plasma membrane plasma membrane Theria Theria Bilateria GFRA4 HGNC:13821 GDNF family receptor alpha 4 Q9GZZ7 Isoform GFRalpha4a: Cell membrane; Lipid- anchor, GPI-anchor. Isoform GFRalpha4b: Cell membrane; Lipid- anchor, GPI-anchor. Isoform GFRalpha4c: Secreted. Plasma membrane (GO:0005886) 10958791 secreted 99 0 secreted secreted Eutheria Eutheria Craniata GFRAL HGNC:32789 GDNF family receptor alpha like Q6UXV0 Membrane; Single-pass membrane protein (Potential). secreted 98 1 secreted secreted Tetrapoda Tetrapoda Bilateria GFY HGNC:44663 golgi-associated, olfactory signaling regulator I3L273 Golgi apparatus membrane; Single-pass type I membrane protein (By similarity). plasma membrane 14 1 plasma membrane plasma membrane NA NA Euarchontoglires GGA1 HGNC:17842 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 Q9UJY5 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Cytosol (GO:0005829); Golgi membrane (GO:0000139); Perinuclear region (GO:0048471) 12221117,12636914,10749927,10747089,12221117,10749927 golgi apparatus 11 0 cytoplasm. golgi apparatus membrane multiple Euteleostomi Bilateria Eukaryota GGA2 HGNC:16064 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 Q9UJY4 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794) 10702286,10814529 golgi apparatus 5 0 golgi apparatus golgi apparatus Amniota Euteleostomi Eukaryota GGA3 HGNC:17079 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 Q9NZ52 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737); Golgi membrane (GO:0000139); Cytosol (GO:0005829);Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737) 10747089,10747089,10747089,12221117,12221117/10747089,10747089,10747089 golgi apparatus 10 0 cytoplasm. golgi apparatus. golgi apparatus membrane multiple Chordata Chordata Eukaryota GGACT HGNC:25100 gamma-glutamylamine cyclotransferase Q9BVM4 cytoplasm 26 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GGCT HGNC:21705 gamma-glutamylcyclotransferase O75223 cytoplasm 20 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GGCX HGNC:4247 gamma-glutamyl carboxylase P38435 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10910912,8702425 endoplasmic reticulum membrane 100 6 endoplasmic reticulum. endoplasmic reticulum membrane multiple Deuterostomia Cell.Organisms Cell.Organisms GGH HGNC:4248 gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) Q92820 Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Lysosome (GO:0005764); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 3759978,10598552,10598552,2867095 secreted 59 0 lysosome. melanosome. secreted multiple Euteleostomi Eukaryota Cell.Organisms GGN HGNC:18869 gametogenetin Q86UU5 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Perinuclear region (GO:0048471) 12574169,12574169,12574169,12574169 cytoplasm 27 0 cytoplasm. nucleus multiple Eutheria Eutheria Mammalia GGNBP2 HGNC:19357 gametogenetin binding protein 2 Q9H3C7 Cytoplasmic vesicle (By similarity). Note=Associated with vesicular structures (By similarity). Nucleus (GO:0005634) 11728448 cytoplasm 96 0 nucleus nucleus Deuterostomia Eukaryota NA GGPS1 HGNC:4249 geranylgeranyl diphosphate synthase 1 O95749 Cytoplasm. Cytoplasm (GO:0005737) 8419360 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms GGT1 HGNC:4250 gamma-glutamyltransferase 1 P19440 Membrane; Single-pass type II membrane protein. Cytoplasm (GO:0005737); Zymogen granule (GO:0042588); Plasma membrane (GO:0005886); Extracellular (GO:0005576) 28899,16278343,12144532,7689219,15528049,9862348,2904146,2869484,7689219 secreted 28 1 cytoplasm. plasma membrane. secreted multiple Opisthokonta Cell.Organisms Cell.Organisms GGT2 HGNC:4251 gamma-glutamyltransferase 2 P36268 Membrane; Single-pass type II membrane protein (By similarity). secreted 26 0 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms GGT5 HGNC:4260 gamma-glutamyltransferase 5 P36269 Membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 11063908,1676842 secreted 19 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GGT6 HGNC:26891 gamma-glutamyltransferase 6 Q6P531 Membrane; Single-pass type II membrane protein (By similarity). secreted 15 1 secreted secreted Mammalia Tetrapoda Cell.Organisms GGT7 HGNC:4259 gamma-glutamyltransferase 7 Q9UJ14 Membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 12562771 secreted 19 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Cell.Organisms GGTLC1 HGNC:16437 gamma-glutamyltransferase light chain 1 Q9BX51 secreted 30 0 secreted secreted Catarrhini Deuterostomia Cell.Organisms GGTLC2 HGNC:18596 gamma-glutamyltransferase light chain 2 Q14390 Plasma membrane (GO:0005886) 8830654 secreted 28 0 secreted secreted Human Human Cell.Organisms GH1 HGNC:4261 growth hormone 1 P01241 Secreted. Extracellular (GO:0005576) 2820841 secreted 100 0 secreted secreted NA NA Cell.Organisms GH2 HGNC:4262 growth hormone 2 P01242 Secreted. Extracellular (GO:0005576) 1955498 secreted 100 0 secreted secreted Homininae Homininae Cell.Organisms GHDC HGNC:24438 GH3 domain containing Q8N2G8 Endoplasmic reticulum. Nucleus envelope (By similarity). cytoplasm 16 0 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms GHITM HGNC:17281 growth hormone inducible transmembrane protein Q9H3K2 Mitochondrion inner membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) mitochondrion membrane 100 7 mitochondrion membrane mitochondrion membrane Bilateria Opisthokonta Cell.Organisms GHR HGNC:4263 growth hormone receptor P10912 Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted. Note=Complexed to a substantial fraction of circulating GH (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9360546,14718574 plasma membrane 52 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Chordata GHRH HGNC:4265 growth hormone releasing hormone P01286 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Euteleostomi Euteleostomi GHRHR HGNC:4266 growth hormone releasing hormone receptor Q02643 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Secretory vesicle (None) 10461027,10461027,10461027,10461027 plasma membrane 100 7 cytoplasm. nucleus. plasma membrane multiple Theria Euteleostomi Holozoa GHRL HGNC:18129 ghrelin/obestatin prepropeptide Q9UBU3 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 14530511,11159851,12107501 secreted 100 0 cytoplasm. secreted multiple Theria Amniota Amniota GHSR HGNC:4267 growth hormone secretagogue receptor Q92847 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9092793 plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Metazoa GID4 HGNC:28453 GID complex subunit 4 Q8IVV7 nucleus 19 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota GID8 HGNC:15857 GID complex subunit 8 Q9NWU2 Nucleus. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GIF HGNC:4268 gastric intrinsic factor (vitamin B synthesis) P27352 Secreted. Extracellular (GO:0005576) 4045300 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Eumetazoa GIGYF1 HGNC:9126 GRB10 interacting GYF protein 1 O75420 cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota GIGYF2 HGNC:11960 GRB10 interacting GYF protein 2 Q6Y7W6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12771153,17081983,17081983 secreted 18 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota GIMAP1 HGNC:23237 GTPase, IMAP family member 1 Q8WWP7 Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane (By similarity). Golgi apparatus (Probable). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11814688,11814688 cytoplasm 39 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Theria Theria Eukaryota GIMAP2 HGNC:21789 GTPase, IMAP family member 2 Q9UG22 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Lipid droplet. Note=Detected on the surface of cytoplasmic lipid droplets. Integral to membrane (GO:0016021) mitochondrion membrane 39 2 cytoplasm. lipid droplet multiple Catarrhini Euteleostomi Eukaryota GIMAP4 HGNC:21872 GTPase, IMAP family member 4 Q9NUV9 Cytoplasm, cytosol. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 15474311,15474311 cytoplasm 100 1 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Theria Eukaryota Eukaryota GIMAP5 HGNC:18005 GTPase, IMAP family member 5 Q96F15 Mitochondrion outer membrane; Single-pass type IV membrane protein (By similarity). Lysosome. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Centrosome (GO:0005813); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11238997,12925764,11238997,12925764,12925764,12925764 mitochondrion membrane 51 1 cytoplasm. endoplasmic reticulum. golgi apparatus. lysosome. mitochondrion multiple Theria Theria Eukaryota GIMAP6 HGNC:21918 GTPase, IMAP family member 6 Q6P9H5 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms GIMAP7 HGNC:22404 GTPase, IMAP family member 7 Q8NHV1 Lipid droplet. Cytoplasm. Note=Colocalizes with GIMAP2 on the surface of cytoplasmic lipid droplets. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 15474311,15474311 cytoplasm 34 0 cytoplasm. endoplasmic reticulum. golgi apparatus. lipid droplet multiple Theria Eukaryota Eukaryota GIMAP8 HGNC:21792 GTPase, IMAP family member 8 Q8ND71 Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Mitochondrion (By similarity). Cytoplasm, cytosol. cytoplasm 29 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms GIMD1 HGNC:44141 GIMAP family P-loop NTPase domain containing 1 P0DJR0 cytoplasm 11 0 cytoplasm cytoplasm NA NA NA GIN1 HGNC:25959 gypsy retrotransposon integrase 1 Q9NXP7 nucleus 41 0 nucleus nucleus Amniota Eukaryota NA GINM1 HGNC:21074 glycoprotein integral membrane 1 Q9NU53 Membrane; Single-pass type I membrane protein (Potential). cytoplasm 14 1 cytoplasm cytoplasm Amniota Euteleostomi Chordata GINS1 HGNC:28980 GINS complex subunit 1 (Psf1 homolog) Q14691 Nucleus (By similarity). nucleus 14 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GINS2 HGNC:24575 GINS complex subunit 2 (Psf2 homolog) Q9Y248 Nucleus (By similarity). nucleus 82 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GINS3 HGNC:25851 GINS complex subunit 3 (Psf3 homolog) Q9BRX5 Nucleus (By similarity). nucleus 10 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GINS4 HGNC:28226 GINS complex subunit 4 (Sld5 homolog) Q9BRT9 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 17081983 nucleus 17 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota GIP HGNC:4270 gastric inhibitory polypeptide P09681 Secreted. Extracellular (GO:0005576) 14988249 secreted 100 0 secreted secreted Eutheria Euteleostomi Tetrapoda GIPC1 HGNC:1226 GIPC PDZ domain containing family, member 1 O14908 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane (GO:0030659); Cytoplasm (GO:0005737) 9770488,9770488,11479315 cytoplasm 65 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa GIPC2 HGNC:18177 GIPC PDZ domain containing family, member 2 Q8TF65 Cytoplasm (Probable). cytoplasm 47 0 cytoplasm cytoplasm Theria Theria Holozoa GIPC3 HGNC:18183 GIPC PDZ domain containing family, member 3 Q8TF64 cytoplasm 59 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa GIPR HGNC:4271 gastric inhibitory polypeptide receptor P48546 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10698169 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Holozoa GIT1 HGNC:4272 G protein-coupled receptor kinase interacting ArfGAP 1 Q9Y2X7 Cytoplasm. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin. Cytoplasm (GO:0005737) 11896197,12695502,17081983 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms GIT2 HGNC:4273 G protein-coupled receptor kinase interacting ArfGAP 2 Q14161 Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Focal adhesion (GO:0005925) 11251077,17081983,11251077,11251077,16628223 cytoplasm 63 0 endoplasmic reticulum. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms GJA1 HGNC:4274 gap junction protein, alpha 1, 43kDa P17302 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Perinuclear region (GO:0048471); Cell surface (GO:0009986) 11313345,15709751,11313345 endoplasmic reticulum membrane 15 4 cytoplasm. plasma membrane multiple Tetrapoda Euteleostomi Bilateria GJA10 HGNC:16995 gap junction protein, alpha 10, 62kDa Q969M2 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). plasma membrane 26 4 plasma membrane plasma membrane Chordata Chordata Bilateria GJA3 HGNC:4277 gap junction protein, alpha 3, 46kDa Q9Y6H8 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 1849321 secreted 20 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Bilateria GJA4 HGNC:4278 gap junction protein, alpha 4, 37kDa P35212 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 7680674 endoplasmic reticulum membrane 21 4 plasma membrane plasma membrane Tetrapoda Tetrapoda Bilateria GJA5 HGNC:4279 gap junction protein, alpha 5, 40kDa P36382 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 7966354,10792506 endoplasmic reticulum membrane 17 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria GJA8 HGNC:4281 gap junction protein, alpha 8, 50kDa P48165 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 1491428 endoplasmic reticulum membrane 32 4 plasma membrane plasma membrane Tetrapoda Euteleostomi NA GJA9 HGNC:19155 gap junction protein, alpha 9, 59kDa P57773 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). Plasma membrane (GO:0005886) plasma membrane 59 4 plasma membrane plasma membrane Catarrhini Euteleostomi Bilateria GJB1 HGNC:4283 gap junction protein, beta 1, 32kDa P08034 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11393532,11393532 endoplasmic reticulum membrane 29 4 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Bilateria GJB2 HGNC:4284 gap junction protein, beta 2, 26kDa P29033 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 12189493 endoplasmic reticulum membrane 27 4 plasma membrane plasma membrane Mammalia Euteleostomi Bilateria GJB3 HGNC:4285 gap junction protein, beta 3, 31kDa O75712 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 12165562,12019212,14583444 endoplasmic reticulum membrane 47 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria GJB4 HGNC:4286 gap junction protein, beta 4, 30.3kDa Q9NTQ9 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 11420600 endoplasmic reticulum membrane 35 4 plasma membrane plasma membrane Mammalia Euteleostomi Bilateria GJB5 HGNC:4287 gap junction protein, beta 5, 31.1kDa O95377 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) endoplasmic reticulum membrane 21 4 plasma membrane plasma membrane Tetrapoda Tetrapoda Bilateria GJB6 HGNC:4288 gap junction protein, beta 6, 30kDa O95452 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 11245683 endoplasmic reticulum membrane 39 4 plasma membrane plasma membrane Amniota Euteleostomi Bilateria GJB7 HGNC:16690 gap junction protein, beta 7, 25kDa Q6PEY0 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 22 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Chordata Bilateria GJC1 HGNC:4280 gap junction protein, gamma 1, 45kDa P36383 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Perinuclear region (GO:0048471); Cell surface (GO:0009986) 11313345,7966354,11313345 endoplasmic reticulum membrane 35 4 cytoplasm. plasma membrane multiple Chordata Chordata Bilateria GJC2 HGNC:17494 gap junction protein, gamma 2, 47kDa Q5T442 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 15192806 endoplasmic reticulum membrane 28 4 plasma membrane plasma membrane Theria Tetrapoda Bilateria GJC3 HGNC:17495 gap junction protein, gamma 3, 30.2kDa Q8NFK1 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). Plasma membrane (GO:0005886) 12151525,15293232,12900929 endoplasmic reticulum membrane 34 4 plasma membrane plasma membrane NA NA Bilateria GJD2 HGNC:19154 gap junction protein, delta 2, 36kDa Q9UKL4 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 10462698 endoplasmic reticulum membrane 41 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria GJD3 HGNC:19147 gap junction protein, delta 3, 31.9kDa Q8N144 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 12154091 endoplasmic reticulum membrane 22 4 plasma membrane plasma membrane Theria Euteleostomi Bilateria GJD4 HGNC:23296 gap junction protein, delta 4, 40.1kDa Q96KN9 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). endoplasmic reticulum membrane 22 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Bilateria GK HGNC:4289 glycerol kinase P32189 Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 2982325,8884278,15561729,8884278 peroxisome 34 1 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms GK2 HGNC:4291 glycerol kinase 2 Q14410 Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm (By similarity). Note=In sperm the majority of the enzyme is bound to mitochondria (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 7987308,7987308 peroxisome 34 1 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms GK5 HGNC:28635 glycerol kinase 5 (putative) Q6ZS86 peroxisome 18 0 peroxisome peroxisome Bilateria Cell.Organisms Cell.Organisms GKAP1 HGNC:17496 G kinase anchoring protein 1 Q5VSY0 Golgi apparatus (By similarity). Golgi apparatus (GO:0005794) 10671526 golgi apparatus 85 0 golgi apparatus golgi apparatus Euteleostomi Bilateria Metazoa GKN1 HGNC:23217 gastrokine 1 Q9NS71 Secreted (By similarity). Extracellular (GO:0005576); Cytoplasmic vesicle (GO:0016023) 12851218,15221938,12851219,15221938 secreted 56 0 secreted secreted Tetrapoda Tetrapoda Tetrapoda GKN2 HGNC:24588 gastrokine 2 Q86XP6 Secreted. secreted 100 0 secreted secreted Tetrapoda Tetrapoda Euteleostomi GLA HGNC:4296 galactosidase, alpha P06280 Lysosome. Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764) 9620884,9620884 secreted 22 0 endoplasmic reticulum. lysosome multiple Bilateria Cell.Organisms NA GLB1 HGNC:4298 galactosidase, beta 1 P16278 Isoform 1: Lysosome. Isoform 2: Cytoplasm, perinuclear region. Note=Localized to the perinuclear area of the cytoplasm but not to lysosomes. Lysosome (GO:0005764) 10737981 secreted 52 0 cytoplasm. lysosome multiple Bilateria Cell.Organisms Cell.Organisms GLB1L HGNC:28129 galactosidase, beta 1-like Q6UWU2 Secreted (Potential). secreted 29 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms GLB1L2 HGNC:25129 galactosidase, beta 1-like 2 Q8IW92 Secreted (Potential). secreted 58 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms GLB1L3 HGNC:25147 galactosidase, beta 1-like 3 Q8NCI6 secreted 33 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms GLCCI1 HGNC:18713 glucocorticoid induced transcript 1 Q86VQ1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 4 0 cytoplasm. nucleus multiple Homininae Euteleostomi Eumetazoa GLCE HGNC:17855 glucuronic acid epimerase O94923 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 95 0 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms GLDC HGNC:4313 glycine dehydrogenase (decarboxylating) P23378 Mitochondrion. Mitochondrion (GO:0005739) 6778858 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GLDN HGNC:29514 gliomedin Q6ZMI3 Cell membrane; Single-pass type II membrane protein. Note=Localizes to the nodes of Ranvier (By similarity). plasma membrane 100 0 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms GLE1 HGNC:4315 GLE1 RNA export mediator Q53GS7 Nucleus. Cytoplasm. Isoform 1: Cytoplasm. Nucleus, nuclear pore complex. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function. Nuclear membrane (GO:0005635); Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737) 9618489,14645504,15561729,14645504,14645504 nucleus 25 0 cytoplasm. nucleus. nucleus membrane multiple Deuterostomia Eukaryota Eukaryota GLG1 HGNC:4316 golgi glycoprotein 1 Q92896 Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 2355176,15561729,9099943,15598749 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. mitochondrion. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms GLI1 HGNC:4317 GLI family zinc finger 1 P08151 Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11717126,,11717126,11960000, nucleus 40 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota GLI2 HGNC:4318 GLI family zinc finger 2 P10070 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12917489,12917489 nucleus 81 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota GLI3 HGNC:4319 GLI family zinc finger 3 P10071 Nucleus. Cytoplasm. Cell projection, cilium. Note=GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10077605,10077605 nucleus 42 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota GLI4 HGNC:4320 GLI family zinc finger 4 P10075 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 nucleus 47 0 nucleus nucleus NA NA Eukaryota GLIPR1 HGNC:17001 GLI pathogenesis-related 1 P48060 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11971968,11971968 secreted 28 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms GLIPR1L1 HGNC:28392 GLI pathogenesis-related 1 like 1 Q6UWM5 Secreted (Potential). secreted 25 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms GLIPR1L2 HGNC:28592 GLI pathogenesis-related 1 like 2 Q4G1C9 Membrane; Single-pass membrane protein (Potential). secreted 16 1 secreted secreted Theria Bilateria Cell.Organisms GLIPR2 HGNC:18007 GLI pathogenesis-related 2 Q9H4G4 Golgi apparatus membrane; Lipid-anchor. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate. secreted 18 0 secreted secreted Bilateria Eukaryota Cell.Organisms GLIS1 HGNC:29525 GLIS family zinc finger 1 Q8NBF1 Nucleus (By similarity). Nucleus (GO:0005634) 12042312 nucleus 79 0 nucleus nucleus Euteleostomi Bilateria Eukaryota GLIS2 HGNC:29450 GLIS family zinc finger 2 Q9BZE0 Nucleus speckle (By similarity). Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11741991,17289029,17081983 nucleus 36 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eukaryota GLIS3 HGNC:28510 GLIS family zinc finger 3 Q8NEA6 Nucleus (By similarity). nucleus 82 0 nucleus nucleus Euteleostomi Bilateria Eukaryota GLMN HGNC:14373 glomulin, FKBP associated protein Q92990 Cytoplasm (GO:0005737) 10051602 nucleus 75 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota GLO1 HGNC:4323 glyoxalase I Q04760 Cytoplasm (GO:0005737) 9593316 cytoplasm 28 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms GLOD4 HGNC:14111 glyoxalase domain containing 4 Q9HC38 Mitochondrion (Probable). Mitochondrion (GO:0005739) 12897971 cytoplasm 41 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms GLOD5 HGNC:33358 glyoxalase domain containing 5 A6NK44 cytoplasm 9 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms NA GLP1R HGNC:4324 glucagon-like peptide 1 receptor P43220 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10382665 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa GLP2R HGNC:4325 glucagon-like peptide 2 receptor O95838 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11238747 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa GLRA1 HGNC:4326 glycine receptor, alpha 1 P23415 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9350397 plasma membrane 7 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GLRA2 HGNC:4327 glycine receptor, alpha 2 P23416 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11409700 plasma membrane 9 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GLRA3 HGNC:4328 glycine receptor, alpha 3 O75311 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9677400 plasma membrane 7 4 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GLRA4 HGNC:31715 glycine receptor, alpha 4 Q5JXX5 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 6 3 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GLRB HGNC:4329 glycine receptor, beta P48167 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10395998 plasma membrane 6 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms GLRX HGNC:4330 glutaredoxin (thioltransferase) P35754 Cytoplasm. Cytoplasm (GO:0005737) 11297543,10037490 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms GLRX2 HGNC:16065 glutaredoxin 2 Q9NS18 Isoform 1: Mitochondrion. Isoform 2: Nucleus. Nucleus (GO:0005634);Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11297543/11297543/15328416,11297543,15328416,11397793 vacuole 21 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms GLRX3 HGNC:15987 glutaredoxin 3 O76003 Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). Cytoplasm (GO:0005737) 10636891 mitochondrion 30 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms GLRX5 HGNC:20134 glutaredoxin 5 Q86SX6 Mitochondrion (By similarity). Mitochondrion (GO:0005739) mitochondrion 58 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms GLS HGNC:4331 glutaminase O94925 Isoform 1: Cytoplasm, cytosol. Isoform 3: Mitochondrion. Mitochondrion (GO:0005739); Golgi apparatus (GO:0005794) 11059811,12629547 mitochondrion 70 0 cytoplasm. golgi apparatus. mitochondrion multiple Bilateria Cell.Organisms Cell.Organisms GLS2 HGNC:29570 glutaminase 2 (liver, mitochondrial) Q9UI32 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 10620514,12163477 mitochondrion 100 0 mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms GLT1D1 HGNC:26483 glycosyltransferase 1 domain containing 1 Q96MS3 Secreted (Potential). cytoplasm 43 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms GLT6D1 HGNC:23671 glycosyltransferase 6 domain containing 1 Q7Z4J2 Membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 43 0 golgi apparatus membrane golgi apparatus membrane Eutheria Eutheria Cell.Organisms GLT8D1 HGNC:24870 glycosyltransferase 8 domain containing 1 Q68CQ7 Membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 12 0 golgi apparatus membrane golgi apparatus membrane Amniota Cell.Organisms Cell.Organisms GLT8D2 HGNC:24890 glycosyltransferase 8 domain containing 2 Q9H1C3 Membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 9 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Cell.Organisms GLTP HGNC:24867 glycolipid transfer protein Q9NZD2 Cytoplasm. Cytoplasm (GO:0005737) 10671554 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota GLTPD1 HGNC:28116 glycolipid transfer protein domain containing 1 Q5TA50 cytoplasm 6 0 cytoplasm cytoplasm NA NA Eukaryota GLTPD2 HGNC:33756 glycolipid transfer protein domain containing 2 A6NH11 Plasma membrane (GO:0005886) secreted 36 0 secreted secreted Theria Theria Holozoa GLTSCR1 HGNC:4332 glioma tumor suppressor candidate region gene 1 Q9NZM4 nucleus 22 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta GLTSCR1L HGNC:21111 GLTSCR1-like Q6AI39 nucleus 82 0 nucleus nucleus Amniota Euteleostomi Eumetazoa GLTSCR2 HGNC:4333 glioma tumor suppressor candidate region gene 2 Q9NZM5 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10196275,10196275,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota GLUD1 HGNC:4335 glutamate dehydrogenase 1 P00367 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytosol (GO:0005829) 3368458,8244384,8486350,15033988,15598749,15561729 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms GLUD2 HGNC:4336 glutamate dehydrogenase 2 P49448 Mitochondrion matrix. Mitochondrion (GO:0005739) 8486350 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GLUL HGNC:4341 glutamate-ammonia ligase P15104 Cytoplasm. Mitochondrion (By similarity). Cytosol (GO:0005829) 2856920 mitochondrion 78 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms GLYAT HGNC:13734 glycine-N-acyltransferase Q6IB77 Mitochondrion. Mitochondrion (GO:0005739) 7802672,9202629 mitochondrion 100 0 mitochondrion mitochondrion Mammalia Euteleostomi Holozoa GLYATL1 HGNC:30519 glycine-N-acyltransferase-like 1 Q969I3 endoplasmic reticulum 39 0 endoplasmic reticulum endoplasmic reticulum Catarrhini Catarrhini Cell.Organisms GLYATL2 HGNC:24178 glycine-N-acyltransferase-like 2 Q8WU03 Endoplasmic reticulum. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Mammalia Euteleostomi Holozoa GLYATL3 HGNC:21349 glycine-N-acyltransferase-like 3 Q5SZD4 mitochondrion 22 0 mitochondrion mitochondrion Mammalia Bilateria Cell.Organisms GLYCTK HGNC:24247 glycerate kinase Q8IVS8 Isoform 1: Cytoplasm. Isoform 2: Cytoplasm. Mitochondrion. cytoplasm 63 0 cytoplasm. mitochondrion multiple Bilateria Cell.Organisms Cell.Organisms GLYR1 HGNC:24434 glyoxylate reductase 1 homolog (Arabidopsis) Q49A26 Nucleus. Nucleus (GO:0005634); Nucleus (GO:0005634) 15561729,17081983 nucleus 100 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms GM2A HGNC:4367 GM2 ganglioside activator P17900 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576) 3935131,9204879 secreted 98 0 lysosome. secreted multiple Euteleostomi Eukaryota Eukaryota GMCL1 HGNC:23843 germ cell-less, spermatogenesis associated 1 Q96IK5 Nucleus matrix (By similarity). Nucleus (GO:0005634) 12954656,12493765,11591818 nucleus 89 0 nucleus nucleus Bilateria Opisthokonta Eukaryota GMDS HGNC:4369 GDP-mannose 4,6-dehydratase O60547 Cytoplasm (GO:0005737) golgi apparatus membrane 13 0 golgi apparatus membrane golgi apparatus membrane Bilateria Cell.Organisms Cell.Organisms GMEB1 HGNC:4370 glucocorticoid modulatory element binding protein 1 Q9Y692 Nucleus. Cytoplasm. Note=May be also cytoplasmic. Nucleus (GO:0005634) 10386584 nucleus 26 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa GMEB2 HGNC:4371 glucocorticoid modulatory element binding protein 2 Q9UKD1 Nucleus. Cytoplasm. Note=May be also cytoplasmic. Nucleus (GO:0005634) 11743720 nucleus 16 0 cytoplasm. nucleus multiple Chordata Chordata Metazoa GMFB HGNC:4373 glia maturation factor, beta P60983 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 2253851,2253851 cytoplasm 6 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota GMFG HGNC:4374 glia maturation factor, gamma O60234 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota GMIP HGNC:24852 GEM interacting protein Q9P107 Plasma membrane (GO:0005886) 12093360 cytoplasm 17 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota GML HGNC:4375 glycosylphosphatidylinositol anchored molecule like Q99445 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Plasma membrane (GO:0005886) secreted 88 0 secreted secreted Eutheria Eutheria Eutheria GMNC HGNC:40049 geminin coiled-coil domain containing A6NCL1 Nucleus (By similarity). Note=Associates with chromatin during pre-replication complex (pre-RC) formation (By similarity). nucleus 45 0 nucleus nucleus Mammalia Euteleostomi Craniata GMNN HGNC:17493 geminin, DNA replication inhibitor O75496 Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus. Nucleus (GO:0005634) 9635433,17318181 nucleus 30 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa GMPPA HGNC:22923 GDP-mannose pyrophosphorylase A Q96IJ6 cytoplasm 22 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms GMPPB HGNC:22932 GDP-mannose pyrophosphorylase B Q9Y5P6 cytoplasm 50 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GMPR HGNC:4376 guanosine monophosphate reductase P36959 Cytoplasm (GO:0005737) 12009299 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms GMPR2 HGNC:4377 guanosine monophosphate reductase 2 Q9P2T1 Cytoplasm (GO:0005737) 12669231 cytoplasm 13 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms GMPS HGNC:4378 guanine monphosphate synthase P49915 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GNA11 HGNC:4379 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) P29992 Cell membrane; Lipid-anchor (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9175863,11507095 cytoplasm 38 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota GNA12 HGNC:4380 guanine nucleotide binding protein (G protein) alpha 12 Q03113 Membrane; Lipid-anchor. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 8290554,15598749 cytoplasm 43 0 mitochondrion mitochondrion Bilateria Bilateria Eukaryota GNA13 HGNC:4381 guanine nucleotide binding protein (G protein), alpha 13 Q14344 Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886) 8290554,10747909 cytoplasm 47 0 melanosome melanosome Bilateria Bilateria Eukaryota GNA14 HGNC:4382 guanine nucleotide binding protein (G protein), alpha 14 O95837 Plasma membrane (GO:0005886) 10625681 cytoplasm 39 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota GNA15 HGNC:4383 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) P30679 Plasma membrane (GO:0005886) 1905813 cytoplasm 30 0 cytoplasm cytoplasm Human Euteleostomi Eukaryota GNAI1 HGNC:4384 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 P63096 Nucleus (By similarity). Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10690676,1953657,17215244,10690676,1953657 cytoplasm 61 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota GNAI2 HGNC:4385 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 P04899 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Cytosol (GO:0005829) 2502457,17215244,2502457,9237368,16263121 cytoplasm 61 0 cytoplasm. endoplasmic reticulum multiple Bilateria Eukaryota NA GNAI3 HGNC:4387 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 P08754 Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8806649,17215244,8806649 cytoplasm 59 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota GNAL HGNC:4388 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type P38405 Secretory granule (GO:0030141); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 10026232,10026232,10026232 cytoplasm 32 0 golgi apparatus golgi apparatus Bilateria Bilateria Eukaryota GNAO1 HGNC:4389 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O P09471 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9359829,8869990,2518353,8869990,8078296 cytoplasm 53 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota GNAQ HGNC:4390 guanine nucleotide binding protein (G protein), q polypeptide P50148 Nucleus (By similarity). Membrane (By similarity). Nucleus membrane (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 9175863,8227063,8227063,8655576 cytoplasm 38 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Eukaryota GNAS HGNC:4392 GNAS complex locus O95467 Cytoplasmic vesicle, secretory vesicle (By similarity). Secreted (By similarity). Note=Neuroendocrine secretory granules (By similarity). Plasma membrane (GO:0005886) 12656668 secreted 38 0 secreted secreted Bilateria Bilateria Eukaryota GNAT1 HGNC:4393 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 P11488 Plasma membrane (GO:0005886) 8673138 cytoplasm 75 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota GNAT2 HGNC:4394 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 P19087 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 3118369,3118369,15598749 cytoplasm 75 0 cytoplasm. mitochondrion multiple Tetrapoda Euteleostomi Eukaryota GNAT3 HGNC:22800 guanine nucleotide binding protein, alpha transducing 3 A8MTJ3 Cytoplasm. Note=Dual ditribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota GNAZ HGNC:4395 guanine nucleotide binding protein (G protein), alpha z polypeptide P19086 Membrane; Lipid-anchor. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12414994,2117645,2117645,2117645,2117645 cytoplasm 48 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Amniota Euteleostomi Eukaryota GNB1 HGNC:4396 guanine nucleotide binding protein (G protein), beta polypeptide 1 P62873 Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 12512701,11294873,17215244,15598749 cytoplasm 88 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms GNB1L HGNC:4397 guanine nucleotide binding protein (G protein), beta polypeptide 1-like Q9BYB4 nucleus 8 0 nucleus nucleus Human Eukaryota Cell.Organisms GNB2 HGNC:4398 guanine nucleotide binding protein (G protein), beta polypeptide 2 P62879 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737) 9648884 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms GNB2L1 HGNC:4399 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 P63244 Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon (By similarity). Cell projection, dendrite (By similarity). Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856) 11046044,12524444,12359736,15561729 cytoplasm 94 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms GNB3 HGNC:4400 guanine nucleotide binding protein (G protein), beta polypeptide 3 P16520 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10513993,10513993 cytoplasm 76 0 cytoplasm cytoplasm Opisthokonta Eukaryota NA GNB4 HGNC:20731 guanine nucleotide binding protein (G protein), beta polypeptide 4 Q9HAV0 Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11294873,17215244,15598749 cytoplasm 88 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms GNB5 HGNC:4401 guanine nucleotide binding protein (G protein), beta 5 O14775 Membrane fraction (GO:0005624) 8910430 cytoplasm 42 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms GNE HGNC:23657 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Q9Y223 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Cytosol (GO:0005829) 9305888,17118363 cytoplasm 98 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms GNG10 HGNC:4402 guanine nucleotide binding protein (G protein), gamma 10 P50151 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) mitochondrion 10 0 mitochondrion mitochondrion NA NA Metazoa GNG11 HGNC:4403 guanine nucleotide binding protein (G protein), gamma 11 P61952 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 9 0 cytoplasm cytoplasm Eutheria Amniota Metazoa GNG12 HGNC:19663 guanine nucleotide binding protein (G protein), gamma 12 Q9UBI6 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm (GO:0005737) 9003074 cytoplasm 8 0 cytoplasm cytoplasm Theria Bilateria Metazoa GNG13 HGNC:14131 guanine nucleotide binding protein (G protein), gamma 13 Q9P2W3 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 12454992,12454992 mitochondrion 13 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa GNG2 HGNC:4404 guanine nucleotide binding protein (G protein), gamma 2 P59768 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). mitochondrion 6 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Metazoa GNG3 HGNC:4405 guanine nucleotide binding protein (G protein), gamma 3 P63215 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). mitochondrion 4 0 mitochondrion mitochondrion Mammalia Euteleostomi Metazoa GNG4 HGNC:4407 guanine nucleotide binding protein (G protein), gamma 4 P50150 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 9 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa GNG5 HGNC:4408 guanine nucleotide binding protein (G protein), gamma 5 P63218 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Integral to membrane (GO:0016021) 9790912 mitochondrion 6 0 mitochondrion mitochondrion Tetrapoda Euteleostomi Metazoa GNG7 HGNC:4410 guanine nucleotide binding protein (G protein), gamma 7 O60262 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9600093,9481488 cytoplasm 7 0 cytoplasm cytoplasm NA NA Metazoa GNG8 HGNC:19664 guanine nucleotide binding protein (G protein), gamma 8 Q9UK08 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) cytoplasm 14 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa GNGT1 HGNC:4411 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 P63211 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) 1706334 cytoplasm 11 0 cytoplasm cytoplasm Eutheria Euteleostomi Metazoa GNGT2 HGNC:4412 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 O14610 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) 9286705 cytoplasm 13 0 cytoplasm cytoplasm Theria Euteleostomi Eumetazoa GNL1 HGNC:4413 guanine nucleotide binding protein-like 1 P36915 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Theria Eukaryota NA GNL2 HGNC:29925 guanine nucleotide binding protein-like 2 (nucleolar) Q13823 Nucleus, nucleolus. Nucleolus (GO:0005730); Ribosome (GO:0005840); Nucleus (GO:0005634); Nucleus (GO:0005634) 8822211,15635413,11790298,15561729,15561729,17081983 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms GNL3 HGNC:29931 guanine nucleotide binding protein-like 3 (nucleolar) Q9BVP2 Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Shuttles between the nucleus and nucleolus (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634) 12464630,15635413,11790298,15857956,15657390,15857956,12464630,15657390,19059367 nucleus 71 1 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms GNL3L HGNC:25553 guanine nucleotide binding protein-like 3 (nucleolar)-like Q9NVN8 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms GNLY HGNC:4414 granulysin P22749 Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation. Extracellular (GO:0005576);Secretory granule (GO:0030141) 9194222,9058801/9058801 secreted 100 0 secreted secreted Homininae Mammalia Bilateria GNMT HGNC:4415 glycine N-methyltransferase Q14749 Cytoplasm. Cytoplasm (GO:0005737) 10843803,12697024 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms GNPAT HGNC:4416 glyceronephosphate O-acyltransferase O15228 Peroxisome membrane; Peripheral membrane protein; Matrix side (By similarity). Note=Exclusively localized to the lumenal side of the peroxisomal membrane (By similarity). Peroxisome (GO:0005777) 2804060 mitochondrion membrane 14 2 peroxisome peroxisome Bilateria Cell.Organisms Cell.Organisms GNPDA1 HGNC:4417 glucosamine-6-phosphate deaminase 1 P46926 Cytoplasm (By similarity). cytoplasm 95 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GNPDA2 HGNC:21526 glucosamine-6-phosphate deaminase 2 Q8TDQ7 Cytoplasm (By similarity). cytoplasm 84 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GNPNAT1 HGNC:19980 glucosamine-phosphate N-acetyltransferase 1 Q96EK6 Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein (By similarity). cytoplasm 77 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms GNPTAB HGNC:29670 N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Q3T906 N-acetylglucosamine-1-phosphotransferase subunit alpha: Golgi apparatus membrane; Single-pass type I membrane protein. N-acetylglucosamine-1-phosphotransferase subunit beta: Golgi apparatus membrane; Single-pass type II membrane protein. golgi apparatus membrane 100 2 golgi apparatus membrane golgi apparatus membrane Deuterostomia Eukaryota Cell.Organisms GNPTG HGNC:23026 N-acetylglucosamine-1-phosphate transferase, gamma subunit Q9UJJ9 Secreted (By similarity). Golgi apparatus (By similarity). Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 3019310,16188874 endoplasmic reticulum 22 0 golgi apparatus. secreted multiple Chordata Chordata Eukaryota GNRH1 HGNC:4419 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) P01148 Secreted. Extracellular (GO:0005576) 2867548 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Euteleostomi GNRH2 HGNC:4420 gonadotropin-releasing hormone 2 O43555 Secreted. Extracellular (GO:0005576) 15001648 secreted 100 0 secreted secreted Catarrhini Eutheria Tetrapoda GNRHR HGNC:4421 gonadotropin-releasing hormone receptor P30968 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 9259321/12943720 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa GNS HGNC:4422 glucosamine (N-acetyl)-6-sulfatase P15586 Lysosome. Lysosome (GO:0005764) 3391615 golgi apparatus 12 0 lysosome lysosome Deuterostomia Cell.Organisms Cell.Organisms GOLGA1 HGNC:4424 golgin A1 Q92805 Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Endosome (GO:0005768) 10209123,12972563,12972563 cytoplasm 15 0 endosome. golgi apparatus multiple Chordata Bilateria Eukaryota GOLGA2 HGNC:4425 golgin A2 Q08379 Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Golgi membrane (GO:0000139) 9628863,8315394,11696556,15037601,15561729,15037601 cytoplasm 8 0 golgi apparatus. golgi apparatus membrane multiple Deuterostomia Bilateria Holozoa GOLGA3 HGNC:4426 golgin A3 Q08378 Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634) 9295333,10791974,9295333,12130652/17081983 cytoplasm 3 0 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Deuterostomia Eukaryota GOLGA4 HGNC:4427 golgin A4 Q13439 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus. Nucleus (GO:0005634);Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 17081983/9013329,14718574 cytoplasm 14 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Chordata Chordata Metazoa GOLGA5 HGNC:4428 golgin A5 Q8TBA6 Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,9915833,18029348,,9915833/17081983,17081983 golgi apparatus membrane 100 1 cytoplasm. endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. nucleus multiple Bilateria Bilateria Eukaryota GOLGA6A HGNC:13567 golgin A6 family, member A Q9NYA3 nucleus 26 0 nucleus nucleus Human Catarrhini Deuterostomia GOLGA6B HGNC:32205 golgin A6 family, member B A6NDN3 Golgi apparatus (GO:0005794) 11161787 nucleus 24 0 golgi apparatus golgi apparatus NA NA Deuterostomia GOLGA6C HGNC:32206 golgin A6 family, member C A6NDK9 nucleus 24 0 nucleus nucleus Human Catarrhini Deuterostomia GOLGA6D HGNC:32204 golgin A6 family, member D P0CG33 nucleus 26 0 nucleus nucleus Human Catarrhini Deuterostomia GOLGA6L1 HGNC:37444 golgin A6 family-like 1 Q8N7Z2 cytoplasm 17 0 cytoplasm cytoplasm Catarrhini Catarrhini Eumetazoa GOLGA6L18 HGNC:49415 golgin A6 family-like 18 D6RB28 nucleus 22 0 nucleus nucleus NA NA Mammalia GOLGA6L19 HGNC:49416 golgin A6 family-like 19 H0YKK7 nucleus 27 0 nucleus nucleus NA NA Mammalia GOLGA6L2 HGNC:26695 golgin A6 family-like 2 Q8N9W4 nucleus 18 0 nucleus nucleus NA NA Bilateria GOLGA6L20 HGNC:49391 golgin A6 family-like 20 A6NFL8 nucleus 35 0 nucleus nucleus NA NA Mammalia GOLGA6L4 HGNC:27256 golgin A6 family-like 4 A6NEF3 nucleus 25 0 nucleus nucleus NA NA Mammalia GOLGA6L6 HGNC:37225 golgin A6 family-like 6 A8MZA4 nucleus 18 0 nucleus nucleus Catarrhini Catarrhini Eumetazoa GOLGA6L9 HGNC:37229 golgin A6 family-like 9 A6NEM1 nucleus 30 0 nucleus nucleus Catarrhini Catarrhini Mammalia GOLGA7 HGNC:24876 golgin A7 Q7Z5G4 Golgi apparatus membrane; Lipid-anchor. Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 14522980,16000296,14522980 mitochondrion 23 1 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota GOLGA7B HGNC:31668 golgin A7 family, member B Q2TAP0 Golgi apparatus membrane; Lipid-anchor (By similarity). cytoplasm 10 1 cytoplasm cytoplasm Theria Eukaryota Eukaryota GOLGA8A HGNC:31972 golgin A8 family, member A A7E2F4 Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794) 10660574,10677249 mitochondrion 16 0 golgi apparatus golgi apparatus Catarrhini Catarrhini Euteleostomi GOLGA8B HGNC:31973 golgin A8 family, member B A8MQT2 Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794) 10677249 mitochondrion 16 0 golgi apparatus golgi apparatus Catarrhini Catarrhini Euteleostomi GOLGA8H HGNC:37443 golgin A8 family, member H P0CJ92 nucleus 13 0 nucleus nucleus NA NA Euteleostomi GOLGA8J HGNC:38650 golgin A8 family, member J A6NMD2 cytoplasm 13 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi GOLGA8K HGNC:38652 golgin A8 family, member K D6RF30 nucleus 12 0 nucleus nucleus NA NA Euteleostomi GOLGA8M HGNC:44404 golgin A8 family, member M H3BSY2 cytoplasm 12 0 cytoplasm cytoplasm NA NA Euteleostomi GOLGA8N HGNC:44405 golgin A8 family, member N F8WBI6 nucleus 29 0 nucleus nucleus NA NA Deuterostomia GOLGA8O HGNC:44406 golgin A8 family, member O A6NCC3 nucleus 29 0 nucleus nucleus NA NA Deuterostomia GOLGA8R HGNC:44407 golgin A8 family, member R I6L899 nucleus 28 0 nucleus nucleus NA NA Deuterostomia GOLGB1 HGNC:4429 golgin B1 Q14789 Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Mitochondrion (GO:0005739) 7691276,14718574,15598749 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. mitochondrion. secreted multiple Amniota Euteleostomi Holozoa GOLIM4 HGNC:15448 golgi integral membrane protein 4 O00461 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome membrane; Single- pass type II membrane protein. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9201717,12191016,12191016,17081983,17081983 nucleus 15 1 cytoplasm. endoplasmic reticulum. endosome membrane. golgi apparatus. golgi apparatus membrane. nucleus multiple Euteleostomi Deuterostomia Eumetazoa GOLM1 HGNC:15451 golgi membrane protein 1 Q8NBJ4 Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption. Golgi apparatus (GO:0005794) 12191016,10831838 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Euteleostomi Bilateria GOLPH3 HGNC:15452 golgi phosphoprotein 3 (coat-protein) Q9H4A6 Cell membrane (By similarity). Endosome (By similarity). Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion intermembrane space. Note=Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgi localization. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11042173,11042173 cytoplasm 22 0 cytoplasm. golgi apparatus multiple Opisthokonta Eukaryota Cell.Organisms GOLPH3L HGNC:24882 golgi phosphoprotein 3-like Q9H4A5 Cytoplasm (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for Golgi localization (By similarity). cytoplasm 23 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms GOLT1A HGNC:24766 golgi transport 1A Q6ZVE7 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 45 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota GOLT1B HGNC:20175 golgi transport 1B Q9Y3E0 Golgi apparatus membrane; Multi-pass membrane protein. golgi apparatus membrane 100 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota GON4L HGNC:25973 gon-4-like (C. elegans) Q3T8J9 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 golgi apparatus membrane 16 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eukaryota GOPC HGNC:17643 golgi-associated PDZ and coiled-coil motif containing Q9HD26 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11384996,11707463,11707463,11707463 secreted 27 0 cytoplasm. golgi apparatus multiple Deuterostomia Bilateria Holozoa GORAB HGNC:25676 golgin, RAB6-interacting Q5T7V8 Cytoplasm. Golgi apparatus. Cytoplasm (GO:0005737) 12783284 nucleus 9 0 cytoplasm. golgi apparatus multiple Chordata Bilateria Holozoa GORASP1 HGNC:16769 golgi reassembly stacking protein 1, 65kDa Q9BQQ3 Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Undergoes rapid exchange with the cytosol. Golgi apparatus (GO:0005794) 9628863 cytoplasm 35 0 golgi apparatus golgi apparatus Euteleostomi Opisthokonta Cell.Organisms GORASP2 HGNC:17500 golgi reassembly stacking protein 2, 55kDa Q9H8Y8 Golgi apparatus membrane; Lipid-anchor. Membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11101516,15037601,17081983,17081983 cytoplasm 18 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota GOSR1 HGNC:4430 golgi SNAP receptor complex member 1 O95249 Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). Nucleus (GO:0005634);Golgi apparatus (GO:0005794) 17081983/9094723,8636227 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. nucleus multiple Opisthokonta Eukaryota Eukaryota GOSR2 HGNC:4431 golgi SNAP receptor complex member 2 O14653 Golgi apparatus membrane; Single-pass type IV membrane protein (Potential). Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 9094723,9349823,9094723,9349823 golgi apparatus membrane 56 1 endoplasmic reticulum. golgi apparatus multiple Opisthokonta Eukaryota Eukaryota GOT1 HGNC:4432 glutamic-oxaloacetic transaminase 1, soluble P17174 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 1974457,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Opisthokonta Cell.Organisms Cell.Organisms GOT1L1 HGNC:28487 glutamic-oxaloacetic transaminase 1-like 1 Q8NHS2 Cytoplasm (By similarity). cytoplasm 27 0 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms GOT2 HGNC:4433 glutamic-oxaloacetic transaminase 2, mitochondrial P00505 Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane. Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 2777255,15635413 mitochondrion 82 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms GP1BA HGNC:4439 glycoprotein Ib (platelet), alpha polypeptide P07359 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2946332,12391017 secreted 22 1 plasma membrane plasma membrane Tetrapoda Eukaryota Cell.Organisms GP1BB HGNC:4440 glycoprotein Ib (platelet), beta polypeptide P13224 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 3161731,12361948 secreted 34 1 plasma membrane plasma membrane Homininae Tetrapoda Chordata GP2 HGNC:4441 glycoprotein 2 (zymogen granule membrane) P55259 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Secreted (By similarity). Note=Secreted after cleavage in the pancreatic juice. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Secretory granule (GO:0030141) 7519402,7503984,2076702,12324456,7519402,7503984,2076702,2011597,8666297,7503984 nucleus 18 1 cytoplasm. plasma membrane. secreted multiple Chordata Chordata Eumetazoa GP5 HGNC:4443 glycoprotein V (platelet) P40197 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7690959,7900083,8608228,7900083 secreted 18 1 cytoplasm. plasma membrane multiple Euarchontoglires Chordata Cell.Organisms GP6 HGNC:14388 glycoprotein VI (platelet) Q9HCN6 Isoform 1: Cell membrane; Single-pass membrane protein. Isoform 2: Cell membrane; Single-pass membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Amniota Amniota NA GP9 HGNC:4444 glycoprotein IX (platelet) P14770 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 3056407,8608228 secreted 41 1 plasma membrane plasma membrane Amniota Euteleostomi Holozoa GPA33 HGNC:4445 glycoprotein A33 (transmembrane) Q99795 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9012807,12114523 secreted 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa GPAA1 HGNC:4446 glycosylphosphatidylinositol anchor attachment 1 O43292 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11483512,12052837,15598749,17081983 endoplasmic reticulum membrane 100 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Opisthokonta Eukaryota NA GPALPP1 HGNC:20298 GPALPP motifs containing 1 Q8IXQ4 nucleus 18 0 nucleus nucleus Bilateria Eukaryota Eukaryota GPAM HGNC:24865 glycerol-3-phosphate acyltransferase, mitochondrial Q9HCL2 Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11546763,2242030,2303421,17081983 mitochondrion membrane 90 4 endoplasmic reticulum. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms GPANK1 HGNC:13920 G patch domain and ankyrin repeats 1 O95872 cytoplasm 69 0 cytoplasm cytoplasm Theria Eukaryota NA GPAT2 HGNC:27168 glycerol-3-phosphate acyltransferase 2, mitochondrial Q6NUI2 Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 79 4 mitochondrion membrane mitochondrion membrane Theria Amniota Holozoa GPATCH1 HGNC:24658 G patch domain containing 1 Q9BRR8 Nucleus (GO:0005634) nucleus 96 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota GPATCH11 HGNC:26768 G patch domain containing 11 Q8N954 nucleus 26 0 nucleus nucleus Bilateria Eukaryota Eukaryota GPATCH2 HGNC:25499 G patch domain containing 2 Q9NW75 Cytoplasm (GO:0005737) 17081983 nucleus 38 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota GPATCH2L HGNC:20210 G patch domain containing 2-like Q9NWQ4 nucleus 99 0 nucleus nucleus Amniota Euteleostomi Eumetazoa GPATCH3 HGNC:25720 G patch domain containing 3 Q96I76 nucleus 57 0 nucleus nucleus Theria Bilateria Eukaryota GPATCH4 HGNC:25982 G patch domain containing 4 Q5T3I0 Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 22 0 nucleus nucleus Theria Eukaryota Eukaryota GPATCH8 HGNC:29066 G patch domain containing 8 Q9UKJ3 Nucleus (GO:0005634) 17081983 nucleus 30 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota GPBAR1 HGNC:19680 G protein-coupled bile acid receptor 1 Q8TDU6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12524422,12524422 plasma membrane 100 7 cytoplasm. plasma membrane multiple Theria Euteleostomi Euteleostomi GPBP1 HGNC:29520 GC-rich promoter binding protein 1 Q86WP2 Nucleus. Cytoplasm. Note=According to PubMed:12842993, it localizes to the cytoplasm. Nucleus (GO:0005634) 14612417 nucleus 94 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Deuterostomia GPBP1L1 HGNC:28843 GC-rich promoter binding protein 1-like 1 Q9HC44 Nucleus (Probable). nucleus 31 0 nucleus nucleus Tetrapoda Euteleostomi Deuterostomia GPC1 HGNC:4449 glypican 1 P35052 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Secreted glypican-1: Secreted, extracellular space. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10527946,11454708 secreted 97 1 endosome. plasma membrane. secreted multiple Euteleostomi Euteleostomi Metazoa GPC2 HGNC:4450 glypican 2 Q8N158 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). Secreted glypican-2: Secreted, extracellular space (By similarity). Plasma membrane (GO:0005886) 8294498 secreted 94 1 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa GPC3 HGNC:4451 glypican 3 P51654 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). Secreted glypican-3: Secreted, extracellular space (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 8589713,9853964 secreted 93 1 plasma membrane. secreted multiple Chordata Chordata Eumetazoa GPC4 HGNC:4452 glypican 4 O75487 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). Secreted glypican-4: Secreted, extracellular space (By similarity). Plasma membrane (GO:0005886) 10585884 secreted 98 1 plasma membrane plasma membrane Bilateria Bilateria Metazoa GPC5 HGNC:4453 glypican 5 P78333 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). Secreted glypican-5: Secreted, extracellular space (By similarity). Plasma membrane (GO:0005886) 9070915 secreted 93 1 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa GPC6 HGNC:4454 glypican 6 Q9Y625 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (By similarity). Secreted glypican-6: Secreted, extracellular space (By similarity). Plasma membrane (GO:0005886) secreted 95 1 secreted secreted Bilateria Bilateria Metazoa GPCPD1 HGNC:26957 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) Q9NPB8 Cytoplasm, cytosol (By similarity). cytoplasm 91 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms GPD1 HGNC:4455 glycerol-3-phosphate dehydrogenase 1 (soluble) P21695 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9851831,15561729 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms GPD1L HGNC:28956 glycerol-3-phosphate dehydrogenase 1-like Q8N335 Cytoplasm. Note=Localized to the region of the plasma membrane. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GPD2 HGNC:4456 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) P43304 Mitochondrion. Mitochondrion (GO:0005739) 8549872 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GPER1 HGNC:4485 G protein-coupled estrogen receptor 1 Q99527 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Protein has been detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is a cell surface or intracellular receptor. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 8920907,15539556,15705806,15705806 plasma membrane 12 7 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Tetrapoda Euteleostomi Eumetazoa GPHA2 HGNC:18054 glycoprotein hormone alpha 2 Q96T91 Secreted. Extracellular (GO:0005576) 12089349 secreted 100 0 secreted secreted Theria Euteleostomi Bilateria GPHB5 HGNC:18055 glycoprotein hormone beta 5 Q86YW7 Secreted. Extracellular (GO:0005576) 12089349 secreted 100 0 secreted secreted Amniota Bilateria NA GPHN HGNC:15465 gephyrin Q9NQX3 Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity). Dendrite (GO:0030425); Nucleus (GO:0005634); Synapse (GO:0045202); Cytosol (GO:0005829); Cytoplasm (GO:0005737) 12535948,10839351,12097491,10839351,10839351,1319186,12097491,17081983 cytoplasm 51 1 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms GPI HGNC:4458 glucose-6-phosphate isomerase P06744 Cytoplasm. Secreted. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11896391,15598749 cytoplasm 64 0 cytoplasm. mitochondrion. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms GPIHBP1 HGNC:24945 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 Q8IV16 Cell membrane; Single-pass membrane protein (Potential). Note=Localized at the cell surface. endoplasmic reticulum 50 1 endoplasmic reticulum endoplasmic reticulum Euarchontoglires Mammalia Mammalia GPKOW HGNC:30677 G patch domain and KOW motifs Q92917 Nucleus (By similarity). Cytoplasm (GO:0005737) 17081983 cytoplasm 13 0 cytoplasm cytoplasm Bilateria Eukaryota NA GPLD1 HGNC:4459 glycosylphosphatidylinositol specific phospholipase D1 P80108 Secreted. Extracellular (GO:0005576) 12367767,11989719 secreted 100 0 secreted secreted Tetrapoda Cell.Organisms Cell.Organisms GPM6A HGNC:4460 glycoprotein M6A P51674 Cell membrane; Multi-pass membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendritic spine (By similarity). Cell projection, filopodium (By similarity). Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity). Plasma membrane (GO:0005886) 12493773 golgi apparatus membrane 40 4 plasma membrane plasma membrane Euteleostomi Bilateria Bilateria GPM6B HGNC:4461 glycoprotein M6B Q13491 Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with SERT at the plasma membrane (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11749036,8398137,8661015,11749036 golgi apparatus membrane 33 4 cytoplasm. plasma membrane multiple Chordata Chordata Bilateria GPN1 HGNC:17030 GPN-loop GTPase 1 Q9HCN4 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12588985,11058119,17081983,12588985,11058119,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Euteleostomi Cell.Organisms GPN2 HGNC:25513 GPN-loop GTPase 2 Q9H9Y4 cytoplasm 36 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms GPN3 HGNC:30186 GPN-loop GTPase 3 Q9UHW5 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms GPNMB HGNC:4462 glycoprotein (transmembrane) nmb Q14956 Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines. Plasma membrane (GO:0005886); Endosome (GO:0005768) 7814155,12638126 golgi apparatus membrane 12 1 endosome. melanosome. plasma membrane multiple Euteleostomi Euteleostomi Deuterostomia GPR1 HGNC:4463 G protein-coupled receptor 1 P46091 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7851889 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa GPR101 HGNC:14963 G protein-coupled receptor 101 Q96P66 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa GPR107 HGNC:17830 G protein-coupled receptor 107 Q5VW38 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) endoplasmic reticulum membrane 36 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota NA GPR108 HGNC:17829 G protein-coupled receptor 108 Q9NPR9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 44 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota GPR110 HGNC:18990 G protein-coupled receptor 110 Q5T601 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Holozoa GPR111 HGNC:18991 G protein-coupled receptor 111 Q8IZF7 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa GPR112 HGNC:18992 G protein-coupled receptor 112 Q8IZF6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Amniota Amniota Eukaryota GPR113 HGNC:18989 G protein-coupled receptor 113 Q8IZF5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12435584 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Tetrapoda Holozoa GPR114 HGNC:19010 G protein-coupled receptor 114 Q8IZF4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Holozoa GPR115 HGNC:19011 G protein-coupled receptor 115 Q8IZF3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa GPR116 HGNC:19030 G protein-coupled receptor 116 Q8IZF2 Cell membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12435584 plasma membrane 66 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa GPR119 HGNC:19060 G protein-coupled receptor 119 Q8TDV5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa GPR12 HGNC:4466 G protein-coupled receptor 12 P47775 Cell membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 12649592 plasma membrane 46 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa GPR123 HGNC:13838 G protein-coupled receptor 123 Q86SQ6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Bilateria Holozoa GPR124 HGNC:17849 G protein-coupled receptor 124 Q96PE1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11559528,12565841 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Bilateria Cell.Organisms GPR125 HGNC:13839 G protein-coupled receptor 125 Q8IWK6 Cell membrane; Multi-pass membrane protein. Nucleus (GO:0005634);Plasma membrane (GO:0005886) 17081983/15203201 plasma membrane 99 7 nucleus. plasma membrane multiple Tetrapoda Bilateria Cell.Organisms GPR126 HGNC:13841 G protein-coupled receptor 126 Q86SQ4 Cell membrane; Multi-pass membrane protein. Note=Detected on the cell surface of activated but not resting umbilical vein. Plasma membrane (GO:0005886) 15225624,15189448 plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Bilateria Eukaryota GPR128 HGNC:19241 G protein-coupled receptor 128 Q96K78 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) ,17081983 plasma membrane 100 8 plasma membrane plasma membrane Chordata Chordata Eukaryota GPR132 HGNC:17482 G protein-coupled receptor 132 Q9UNW8 Cell membrane; Multi-pass membrane protein (Probable). Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). Plasma membrane (GO:0005886) plasma membrane 17 7 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa GPR133 HGNC:19893 G protein-coupled receptor 133 Q6QNK2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Eukaryota GPR135 HGNC:19991 G protein-coupled receptor 135 Q8IZ08 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14623098,12732197 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Eumetazoa GPR137 HGNC:24300 G protein-coupled receptor 137 Q96N19 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane Mammalia Mammalia Holozoa GPR137B HGNC:11862 G protein-coupled receptor 137B O60478 Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9521871 plasma membrane 34 7 lysosome membrane. plasma membrane multiple Deuterostomia Eukaryota Holozoa GPR137C HGNC:25445 G protein-coupled receptor 137C Q8N3F9 Membrane; Multi-pass membrane protein (Potential). plasma membrane 31 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa GPR139 HGNC:19995 G protein-coupled receptor 139 Q6DWJ6 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa GPR141 HGNC:19997 G protein-coupled receptor 141 Q7Z602 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 3 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa GPR142 HGNC:20088 G protein-coupled receptor 142 Q7Z601 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Bilateria GPR143 HGNC:20145 G protein-coupled receptor 143 P51810 Golgi apparatus. Melanosome membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764); Endosome (GO:0005768); Plasma membrane (GO:0005886) 11115845,10471510,11115845,11115845,10471510,11115845 plasma membrane 85 7 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome. lysosome membrane. melanosome membrane. plasma membrane multiple Euteleostomi Bilateria Holozoa GPR144 HGNC:18651 G protein-coupled receptor 144 Q7Z7M1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 15203201 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms GPR146 HGNC:21718 G protein-coupled receptor 146 Q96CH1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria GPR148 HGNC:23623 G protein-coupled receptor 148 Q8TDV2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Catarrhini Euteleostomi Bilateria GPR149 HGNC:23627 G protein-coupled receptor 149 Q86SP6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 12679517 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Craniata GPR15 HGNC:4469 G protein-coupled receptor 15 P49685 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11696454,11696454 plasma membrane 100 7 cytoplasm. plasma membrane multiple Eutheria Amniota Metazoa GPR150 HGNC:23628 G protein-coupled receptor 150 Q8NGU9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Deuterostomia Bilateria GPR151 HGNC:23624 G protein-coupled receptor 151 Q8TDV0 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Bilateria GPR152 HGNC:23622 G protein-coupled receptor 152 Q8TDT2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Cell.Organisms GPR153 HGNC:23618 G protein-coupled receptor 153 Q6NV75 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria GPR155 HGNC:22951 G protein-coupled receptor 155 Q7Z3F1 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 19 17 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms GPR156 HGNC:20844 G protein-coupled receptor 156 Q8NFN8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 12591167,12591167 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Holozoa GPR157 HGNC:23687 G protein-coupled receptor 157 Q5UAW9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota GPR158 HGNC:23689 G protein-coupled receptor 158 Q5T848 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Bilateria Eukaryota GPR160 HGNC:23693 G protein-coupled receptor 160 Q9UJ42 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 12044878 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Euteleostomi GPR161 HGNC:23694 G protein-coupled receptor 161 Q8N6U8 Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). Integral to membrane (GO:0016021) plasma membrane 10 7 plasma membrane plasma membrane Deuterostomia Deuterostomia Metazoa GPR162 HGNC:16693 G protein-coupled receptor 162 Q16538 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) 15777626 plasma membrane 49 7 plasma membrane plasma membrane NA NA NA GPR17 HGNC:4471 G protein-coupled receptor 17 Q13304 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Metazoa GPR171 HGNC:30057 G protein-coupled receptor 171 O14626 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Metazoa GPR173 HGNC:18186 G protein-coupled receptor 173 Q9NS66 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10833454 plasma membrane 6 7 plasma membrane plasma membrane Euteleostomi Euteleostomi NA GPR174 HGNC:30245 G protein-coupled receptor 174 Q9BXC1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Metazoa GPR176 HGNC:32370 G protein-coupled receptor 176 Q14439 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa GPR179 HGNC:31371 G protein-coupled receptor 179 Q6PRD1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Tetrapoda Bilateria NA GPR18 HGNC:4472 G protein-coupled receptor 18 Q14330 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa GPR180 HGNC:28899 G protein-coupled receptor 180 Q86V85 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12538434 endoplasmic reticulum membrane 39 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota GPR182 HGNC:13708 G protein-coupled receptor 182 O15218 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11883938 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa GPR183 HGNC:3128 G protein-coupled receptor 183 P32249 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 8383238 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Metazoa GPR19 HGNC:4473 G protein-coupled receptor 19 Q15760 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8830667 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Deuterostomia Metazoa GPR20 HGNC:4475 G protein-coupled receptor 20 Q99678 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa GPR21 HGNC:4476 G protein-coupled receptor 21 Q99679 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Deuterostomia Metazoa GPR22 HGNC:4477 G protein-coupled receptor 22 Q99680 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa GPR25 HGNC:4480 G protein-coupled receptor 25 O00155 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Euteleostomi Eumetazoa GPR26 HGNC:4481 G protein-coupled receptor 26 Q8NDV2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 6 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa GPR27 HGNC:4482 G protein-coupled receptor 27 Q9NS67 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10833454 plasma membrane 7 7 plasma membrane plasma membrane Homininae Theria Bilateria GPR3 HGNC:4484 G protein-coupled receptor 3 P46089 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7832990 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Mammalia Eumetazoa GPR31 HGNC:4486 G protein-coupled receptor 31 O00270 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 6 plasma membrane plasma membrane Theria Theria Eumetazoa GPR32 HGNC:4487 G protein-coupled receptor 32 O75388 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa GPR33 HGNC:4489 G protein-coupled receptor 33 (gene/pseudogene) Q49SQ1 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa GPR34 HGNC:4490 G protein-coupled receptor 34 Q9UPC5 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10395919,10036181 plasma membrane 12 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa GPR35 HGNC:4492 G protein-coupled receptor 35 Q9HC97 Cell membrane; Multi-pass membrane protein. Note=Internalized to the cytoplasm after exposure to kynurenic acid. Integral to membrane (GO:0016021) 947955 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa GPR37 HGNC:4494 G protein-coupled receptor 37 (endothelin receptor type B-like) O15354 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11439185,11439185,11439185 plasma membrane 8 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane multiple Chordata Chordata Eumetazoa GPR37L1 HGNC:14923 G protein-coupled receptor 37 like 1 O60883 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle (GO:0016023) plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa GPR39 HGNC:4496 G protein-coupled receptor 39 O43194 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9441746 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa GPR4 HGNC:4497 G protein-coupled receptor 4 P46093 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14567679 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Euteleostomi Eumetazoa GPR42 HGNC:4500 G protein-coupled receptor 42 (gene/pseudogene) O15529 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9344866 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa GPR45 HGNC:4503 G protein-coupled receptor 45 Q9Y5Y3 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10036181,11027575 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Euteleostomi Metazoa GPR50 HGNC:4506 G protein-coupled receptor 50 Q13585 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8647286,16778767 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms GPR52 HGNC:4508 G protein-coupled receptor 52 Q9Y2T5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9931487 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Metazoa GPR55 HGNC:4511 G protein-coupled receptor 55 Q9Y2T6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9931487 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa GPR56 HGNC:4512 G protein-coupled receptor 56 Q9Y653 Cell membrane; Multi-pass membrane protein. GPR56 N-terminal fragment: Secreted. Plasma membrane (GO:0005886) 10049584,15004227 plasma membrane 21 7 plasma membrane. secreted multiple Tetrapoda Tetrapoda Holozoa GPR6 HGNC:4515 G protein-coupled receptor 6 P46095 Cell membrane; Multi-pass membrane protein (Probable). Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor. Plasma membrane (GO:0005886) 12649592 plasma membrane 48 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa GPR61 HGNC:13300 G protein-coupled receptor 61 Q9BZJ8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Deuterostomia Eumetazoa GPR62 HGNC:13301 G protein-coupled receptor 62 Q9BZJ7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Amniota GPR63 HGNC:13302 G protein-coupled receptor 63 Q9BZJ6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11027575 plasma membrane 100 7 plasma membrane plasma membrane Theria Deuterostomia Metazoa GPR64 HGNC:4516 G protein-coupled receptor 64 Q8IZP9 Cell membrane; Multi-pass membrane protein. Nucleus (GO:0005634);Plasma membrane (GO:0005886) 17081983/9150425,12420295 plasma membrane 100 8 nucleus. plasma membrane multiple Amniota Amniota Eukaryota GPR65 HGNC:4517 G protein-coupled receptor 65 Q8IYL9 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 24 7 plasma membrane plasma membrane Amniota Amniota Eumetazoa GPR68 HGNC:4519 G protein-coupled receptor 68 Q15743 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12069813 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa GPR75 HGNC:4526 G protein-coupled receptor 75 O95800 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10381362 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Bilateria GPR78 HGNC:4528 G protein-coupled receptor 78 Q96P69 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 6 plasma membrane plasma membrane Catarrhini Catarrhini Eumetazoa GPR82 HGNC:4533 G protein-coupled receptor 82 Q96P67 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa GPR83 HGNC:4523 G protein-coupled receptor 83 Q9NYM4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa GPR84 HGNC:4535 G protein-coupled receptor 84 Q9NQS5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Bilateria Eumetazoa GPR85 HGNC:4536 G protein-coupled receptor 85 P60893 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10833454 plasma membrane 6 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa GPR87 HGNC:4538 G protein-coupled receptor 87 Q9BY21 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 9 7 plasma membrane plasma membrane Amniota Amniota Metazoa GPR88 HGNC:4539 G protein-coupled receptor 88 Q9GZN0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Euteleostomi GPR89A HGNC:31984 G protein-coupled receptor 89A B7ZAQ6 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 96 9 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota NA GPR89B HGNC:13840 G protein-coupled receptor 89B P0CG08 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 96 9 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota NA GPR89C HGNC:31985 G protein-coupled receptor 89C A6NKF9 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 95 5 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota GPR97 HGNC:13728 G protein-coupled receptor 97 Q86Y34 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Amniota Amniota Holozoa GPR98 HGNC:17416 G protein-coupled receptor 98 Q8WXG9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11606593,10976914 plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms GPRASP1 HGNC:24834 G protein-coupled receptor associated sorting protein 1 Q5JY77 Cytoplasm. Cytoplasm (GO:0005737) 12142540 cytoplasm 100 0 cytoplasm cytoplasm Euarchontoglires Eutheria Bilateria GPRASP2 HGNC:25169 G protein-coupled receptor associated sorting protein 2 Q96D09 Nucleus (GO:0005634) 15302935 cytoplasm 47 0 nucleus nucleus Euarchontoglires Eutheria Cell.Organisms GPRC5A HGNC:9836 G protein-coupled receptor, class C, group 5, member A Q8NFJ5 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Microsome (GO:0005792) 9857033,9857033,9857033 plasma membrane 71 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Craniata GPRC5B HGNC:13308 G protein-coupled receptor, class C, group 5, member B Q9NZH0 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles. Plasma membrane (GO:0005886) 10945465 plasma membrane 84 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa GPRC5C HGNC:13309 G protein-coupled receptor, class C, group 5, member C Q9NQ84 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles. Cell surface (GO:0009986); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Perinuclear vesicle (None) 10945465,10945465,10945465,10945465 plasma membrane 88 7 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Tetrapoda Euteleostomi Deuterostomia GPRC5D HGNC:13310 G protein-coupled receptor, class C, group 5, member D Q9NZD1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11311935 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Craniata GPRC6A HGNC:18510 G protein-coupled receptor, class C, group 6, member A Q5T6X5 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 75 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota GPRIN1 HGNC:24835 G protein regulated inducer of neurite outgrowth 1 Q7Z2K8 Cell membrane; Lipid-anchor (By similarity). Cell projection, growth cone (By similarity). Note=Highly enriched in growth cone (By similarity). cytoplasm 8 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota GPRIN2 HGNC:23730 G protein regulated inducer of neurite outgrowth 2 O60269 nucleus 62 0 nucleus nucleus Tetrapoda Tetrapoda NA GPRIN3 HGNC:27733 GPRIN family member 3 Q6ZVF9 nucleus 83 0 nucleus nucleus Human Human Bilateria GPS1 HGNC:4549 G protein pathway suppressor 1 Q13098 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11114242,11114242,11114242 nucleus 25 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota GPS2 HGNC:4550 G protein pathway suppressor 2 Q13227 Nucleus (GO:0005634) 11931768,9372953 cytoplasm 15 0 nucleus nucleus Theria Deuterostomia Craniata GPSM1 HGNC:17858 G-protein signaling modulator 1 Q86YR5 Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737) 11278352 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria NA GPSM2 HGNC:29501 G-protein signaling modulator 2 P81274 Cytoplasm. Cytoplasm, cell cortex. Note=Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11781568,12925752,11832491,11832491 mitochondrion membrane 12 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms GPSM3 HGNC:13945 G-protein signaling modulator 3 Q9Y4H4 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Theria Theria NA GPT HGNC:4552 glutamic-pyruvate transaminase (alanine aminotransferase) P24298 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11863375,11863375 cytoplasm 100 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms GPT2 HGNC:18062 glutamic pyruvate transaminase (alanine aminotransferase) 2 Q8TD30 Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11863375,11863375 cytoplasm 62 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms GPX1 HGNC:4553 glutathione peroxidase 1 P07203 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 1556108,8001233,10880344,10833429,9126277,8428933,12470500 cytoplasm 100 2 cytoplasm. mitochondrion multiple NA NA Cell.Organisms GPX2 HGNC:4554 glutathione peroxidase 2 (gastrointestinal) P18283 Cytoplasm. Note=Mainly cytoplasmic. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8428933,11373322,11373322 cytoplasm 100 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Cell.Organisms GPX3 HGNC:4555 glutathione peroxidase 3 (plasma) P22352 Secreted. Extracellular (GO:0005576) 11149894 secreted 100 0 secreted secreted Deuterostomia Bilateria Cell.Organisms GPX4 HGNC:4556 glutathione peroxidase 4 P36969 Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12427732,1556123,11344099,1556123,9705830,1556123 nucleus 83 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms GPX5 HGNC:4557 glutathione peroxidase 5 (epididymal androgen-related protein) O75715 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12211066,9110319,12211066,9783843 secreted 100 0 secreted secreted NA NA Cell.Organisms GPX6 HGNC:4558 glutathione peroxidase 6 (olfactory) P59796 Secreted (By similarity). secreted 67 0 secreted secreted Deuterostomia Bilateria Cell.Organisms GPX7 HGNC:4559 glutathione peroxidase 7 Q96SL4 Secreted (Potential). Cytoplasm (GO:0005737) 15294905 mitochondrion 29 1 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GPX8 HGNC:33100 glutathione peroxidase 8 (putative) Q8TED1 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion 28 1 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GRAMD1A HGNC:29305 GRAM domain containing 1A Q96CP6 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,17081983 secreted 25 1 secreted secreted Bilateria Eukaryota Eukaryota GRAMD1B HGNC:29214 GRAM domain containing 1B Q3KR37 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 28 1 nucleus nucleus Bilateria Eukaryota Eukaryota GRAMD1C HGNC:25252 GRAM domain containing 1C Q8IYS0 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 21 1 secreted secreted Tetrapoda Eukaryota Eukaryota GRAMD2 HGNC:27287 GRAM domain containing 2 Q8IUY3 Membrane; Single-pass membrane protein (Potential). secreted 50 1 secreted secreted Amniota Euteleostomi Eukaryota GRAMD3 HGNC:24911 GRAM domain containing 3 Q96HH9 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 secreted 43 1 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota GRAMD4 HGNC:29113 GRAM domain containing 4 Q6IC98 Mitochondrion membrane; Multi-pass membrane protein (Potential). Note=Colocalizes with COX4I1. Mitochondrion (GO:0005739) 15565177 secreted 10 4 mitochondrion mitochondrion Euteleostomi Euteleostomi Eukaryota GRAP HGNC:4562 GRB2-related adaptor protein Q13588 Cytoplasm (GO:0005737) 8647802 cytoplasm 28 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota GRAP2 HGNC:4563 GRB2-related adaptor protein 2 O75791 Nucleus. Cytoplasm. Endosome. Cytoplasm (GO:0005737) 9878555 cytoplasm 36 0 cytoplasm. endosome. nucleus multiple Euteleostomi Bilateria Eukaryota GRAPL HGNC:37240 GRB2-related adaptor protein-like Q8TC17 cytoplasm 38 0 cytoplasm cytoplasm NA NA Eukaryota GRASP HGNC:18707 GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein Q7Z6J2 Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Localized at postsynaptic membranes (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10828067,10828067 cytoplasm 14 0 cytoplasm cytoplasm Theria Bilateria Metazoa GRB10 HGNC:4564 growth factor receptor-bound protein 10 Q13322 Cytoplasm (By similarity). Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R- containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Membrane fraction (GO:0005624) 9006901,10585452,9006901 cytoplasm 87 0 cytoplasm. mitochondrion multiple Chordata Chordata Holozoa GRB14 HGNC:4565 growth factor receptor-bound protein 14 Q14449 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane. Golgi apparatus (GO:0005794); Endosome (GO:0005768); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 11278563,11278563,11607834,11278563,11278563,11278563 cytoplasm 51 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus multiple Euteleostomi Deuterostomia Holozoa GRB2 HGNC:4566 growth factor receptor-bound protein 2 P62993 Nucleus. Cytoplasm. Endosome. Golgi apparatus (By similarity). Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 17081983/10051406,9516488,15122321,7527043 cytoplasm 34 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Eukaryota GRB7 HGNC:4567 growth factor receptor-bound protein 7 Q14451 Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule (By similarity). Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10893408,11607834,10893408,11607834 cytoplasm 47 0 cytoplasm cytoplasm Theria Tetrapoda Holozoa GREB1 HGNC:24885 growth regulation by estrogen in breast cancer 1 Q4ZG55 Membrane; Single-pass membrane protein (Potential). nucleus 69 1 nucleus nucleus Deuterostomia Deuterostomia Holozoa GREB1L HGNC:31042 growth regulation by estrogen in breast cancer-like Q9C091 Membrane; Single-pass membrane protein (Potential). nucleus 70 1 nucleus nucleus Deuterostomia Deuterostomia Holozoa GREM1 HGNC:2001 gremlin 1, DAN family BMP antagonist O60565 Secreted (Probable). Extracellular (GO:0005576) 12808456 secreted 21 0 secreted secreted Chordata Bilateria Eumetazoa GREM2 HGNC:17655 gremlin 2, DAN family BMP antagonist Q9H772 Secreted (Probable). Extracellular (GO:0005576) 15039429 secreted 23 0 secreted secreted Amniota Euteleostomi Eumetazoa GRHL1 HGNC:17923 grainyhead-like 1 (Drosophila) Q9NZI5 Nucleus. Nucleus (GO:0005634) 10644752 nucleus 100 0 nucleus nucleus Chordata Bilateria Opisthokonta GRHL2 HGNC:2799 grainyhead-like 2 (Drosophila) Q6ISB3 Nucleus. Nucleus (GO:0005634) none,19059367 nucleus 100 0 nucleus nucleus Chordata Bilateria Opisthokonta GRHL3 HGNC:25839 grainyhead-like 3 (Drosophila) Q8TE85 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta GRHPR HGNC:4570 glyoxylate reductase/hydroxypyruvate reductase Q9UBQ7 Cytoplasm (GO:0005737) 10524214 cytoplasm 22 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms GRIA1 HGNC:4571 glutamate receptor, ionotropic, AMPA 1 P42261 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8163463,10751563,10023812 plasma membrane 39 3 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms GRIA2 HGNC:4572 glutamate receptor, ionotropic, AMPA 2 P42262 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Synapse (GO:0045202); Perinuclear region (GO:0048471) 12062022,10985351,16055064,12062022,10027300,16055064 golgi apparatus membrane 41 3 cytoplasm. endoplasmic reticulum. plasma membrane multiple Bilateria Eukaryota Cell.Organisms GRIA3 HGNC:4573 glutamate receptor, ionotropic, AMPA 3 P42263 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression (By similarity). Cell surface (GO:0009986); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12682273,12682273,12682273 golgi apparatus membrane 35 3 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms GRIA4 HGNC:4574 glutamate receptor, ionotropic, AMPA 4 P48058 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression (By similarity). Plasma membrane (GO:0005886) 8163463 golgi apparatus membrane 29 3 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms GRID1 HGNC:4575 glutamate receptor, ionotropic, delta 1 Q9ULK0 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 59 4 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms GRID2 HGNC:4576 glutamate receptor, ionotropic, delta 2 O43424 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Dendrite (GO:0030425); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Focal adhesion (GO:0005925) 9465309,14572453,14572453,14572453,14572453 secreted 56 4 cytoplasm. golgi apparatus. plasma membrane multiple Euteleostomi Eukaryota Cell.Organisms GRID2IP HGNC:18464 glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein A4D2P6 Cell junction, synapse, postsynaptic cell membrane (By similarity). nucleus 23 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota GRIFIN HGNC:4577 galectin-related inter-fiber protein A4D1Z8 nucleus 17 0 nucleus nucleus NA NA NA GRIK1 HGNC:4579 glutamate receptor, ionotropic, kainate 1 P39086 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8163463,10023812 plasma membrane 11 3 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms GRIK2 HGNC:4580 glutamate receptor, ionotropic, kainate 2 Q13002 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8163463 plasma membrane 14 3 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms GRIK3 HGNC:4581 glutamate receptor, ionotropic, kainate 3 Q13003 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8163463 plasma membrane 12 3 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms GRIK4 HGNC:4582 glutamate receptor, ionotropic, kainate 4 Q16099 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8263508 plasma membrane 44 4 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms GRIK5 HGNC:4583 glutamate receptor, ionotropic, kainate 5 Q16478 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 14511640,14511640 plasma membrane 42 4 endoplasmic reticulum. plasma membrane multiple Bilateria Eukaryota NA GRIN1 HGNC:4584 glutamate receptor, ionotropic, N-methyl D-aspartate 1 Q05586 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Synapse (GO:0045202) 14732708,14732708,15978582 plasma membrane 13 5 endoplasmic reticulum. plasma membrane multiple Chordata Bilateria Cell.Organisms GRIN2A HGNC:4585 glutamate receptor, ionotropic, N-methyl D-aspartate 2A Q12879 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Early endosome (GO:0005769); Late endosome (GO:0005770); Cytoplasm (GO:0005737) 8163463,15254094,15254094,17081983 nucleus 33 4 cytoplasm. endosome. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms GRIN2B HGNC:4586 glutamate receptor, ionotropic, N-methyl D-aspartate 2B Q13224 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Early endosome (GO:0005769) 8163463,15254094 nucleus 28 4 endosome. plasma membrane multiple Euteleostomi Bilateria NA GRIN2C HGNC:4587 glutamate receptor, ionotropic, N-methyl D-aspartate 2C Q14957 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9037519 nucleus 16 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms GRIN2D HGNC:4588 glutamate receptor, ionotropic, N-methyl D-aspartate 2D O15399 Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9489750 cytoplasm 18 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms GRIN3A HGNC:16767 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Q8TCU5 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). Integral to membrane (GO:0016021); Plasma membrane (GO:0005886) 11735224,15194871 secreted 20 4 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms GRIN3B HGNC:16768 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B O60391 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). Integral to membrane (GO:0016021) 11717388 secreted 68 5 n/a n/a Euteleostomi Bilateria Cell.Organisms GRINA HGNC:4589 glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) Q7Z429 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 1719427 secreted 30 7 n/a n/a Theria Eukaryota NA GRIP1 HGNC:18708 glutamate receptor interacting protein 1 Q9Y3R0 Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 10197531,10197531 cytoplasm 56 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Bilateria Holozoa GRIP2 HGNC:23841 glutamate receptor interacting protein 2 Q9C0E4 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). cytoplasm 65 0 cytoplasm cytoplasm Deuterostomia Bilateria NA GRIPAP1 HGNC:18706 GRIP1 associated protein 1 Q4V328 Early endosome. Endosome (GO:0005768); Cytoplasm (GO:0005737); Synapse (GO:0045202); Membrane fraction (GO:0005624); Nucleus (GO:0005634) 15897011,10896157,10896157,10896157,17081983 cytoplasm 15 0 cytoplasm. endosome. nucleus multiple Mammalia Deuterostomia Holozoa GRK1 HGNC:10013 G protein-coupled receptor kinase 1 Q15835 Membrane; Lipid-anchor. Cytoplasm (GO:0005737) 9501174 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms GRK4 HGNC:4543 G protein-coupled receptor kinase 4 P32298 Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. Mitochondrion (GO:0005739); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 9092566,9092566,9092566 nucleus 21 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion multiple Bilateria Bilateria Cell.Organisms GRK5 HGNC:4544 G protein-coupled receptor kinase 5 P34947 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9813065,9813065,9813065 nucleus 20 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms GRK6 HGNC:4545 G protein-coupled receptor kinase 6 P43250 Membrane; Lipid-anchor. Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 17081983/9341194,7961702,9819198,9819198 nucleus 20 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms GRK7 HGNC:17031 G protein-coupled receptor kinase 7 Q8WTQ7 Membrane; Lipid-anchor. Plasma membrane (GO:0005886) 11754336 cytoplasm 20 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms GRM1 HGNC:4593 glutamate receptor, metabotropic 1 Q13255 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 10945991,10530810,10349865,9582347,11905408,10349865,11905408,10349865 plasma membrane 100 7 endoplasmic reticulum. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms GRM2 HGNC:4594 glutamate receptor, metabotropic 2 Q14416 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7620613 plasma membrane 61 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GRM3 HGNC:4595 glutamate receptor, metabotropic 3 Q14832 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8840013 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GRM4 HGNC:4596 glutamate receptor, metabotropic 4 Q14833 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7617140 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GRM5 HGNC:4597 glutamate receptor, metabotropic 5 P41594 Cell membrane; Multi-pass membrane protein. Nuclear membrane (GO:0005635); Plasma membrane (GO:0005886); Endoplasmic reticulum membrane (GO:0005789) 12736269,12736269,12736269 plasma membrane 100 7 endoplasmic reticulum membrane. nucleus membrane. plasma membrane multiple Bilateria Bilateria Cell.Organisms GRM6 HGNC:4598 glutamate receptor, metabotropic 6 O15303 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9215706 plasma membrane 65 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GRM7 HGNC:4599 glutamate receptor, metabotropic 7 Q14831 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8840028,9473604 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GRM8 HGNC:4600 glutamate receptor, metabotropic 8 O00222 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8824806 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms GRN HGNC:4601 granulin P28799 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 8496151,12588988 secreted 100 0 cytoplasm. secreted multiple Deuterostomia Eukaryota Eukaryota GRP HGNC:4605 gastrin-releasing peptide P07492 Secreted. Extracellular (GO:0005576) 11960700 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Euteleostomi GRPEL1 HGNC:19696 GrpE-like 1, mitochondrial (E. coli) Q9HAV7 Mitochondrion matrix. Mitochondrion (GO:0005739) 11311562,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GRPEL2 HGNC:21060 GrpE-like 2, mitochondrial (E. coli) Q8TAA5 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 9694873 mitochondrion 82 0 mitochondrion mitochondrion Tetrapoda Eukaryota Cell.Organisms GRPR HGNC:4609 gastrin-releasing peptide receptor P30550 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8391296 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa GRSF1 HGNC:4610 G-rich RNA sequence binding factor 1 Q12849 Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note=Forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 8036161,11790298,15598749 nucleus 32 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Eukaryota GRTP1 HGNC:20310 growth hormone regulated TBC protein 1 Q5TC63 nucleus 13 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota GRWD1 HGNC:21270 glutamate-rich WD repeat containing 1 Q9BQ67 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 12549820,17081983,12429849,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms GRXCR1 HGNC:31673 glutaredoxin, cysteine rich 1 A8MXD5 Cell projection, stereocilium (By similarity). Cell projection, microvillus (By similarity). Cell projection, kinocilium (By similarity). Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia (By similarity). mitochondrion 22 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota GRXCR2 HGNC:33862 glutaredoxin, cysteine rich 2 A6NFK2 nucleus 72 0 nucleus nucleus Amniota Euteleostomi Metazoa GSAP HGNC:28042 gamma-secretase activating protein A4D1B5 Golgi apparatus, trans-Golgi network. golgi apparatus 100 0 golgi apparatus golgi apparatus Amniota Euteleostomi Holozoa GSC HGNC:4612 goosecoid homeobox P56915 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Chordata Bilateria Eukaryota GSC2 HGNC:4613 goosecoid homeobox 2 O15499 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Amniota Amniota NA GSDMA HGNC:13311 gasdermin A Q96QA5 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737) 10967128 cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Euteleostomi GSDMB HGNC:23690 gasdermin B Q8TAX9 Cytoplasm. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells. cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Theria Amniota GSDMC HGNC:7151 gasdermin C Q9BYG8 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11223543,11223543 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Theria Chordata GSDMD HGNC:25697 gasdermin D P57764 cytoplasm 20 0 cytoplasm cytoplasm Theria Theria Euteleostomi GSE1 HGNC:28979 Gse1 coiled-coil protein Q14687 cytoplasm 36 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta GSG1 HGNC:19716 germ cell associated 1 Q2KHT4 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with PAPOLB in the endoplasmic reticulum (By similarity). endoplasmic reticulum membrane 70 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Chordata GSG1L HGNC:28283 GSG1-like Q6UXU4 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse (By similarity). endoplasmic reticulum membrane 42 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Chordata GSG2 HGNC:19682 germ cell associated 2 (haspin) Q8TF76 Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. Nucleus (GO:0005634) 15681610,11228240,11311556 cytoplasm 57 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota GSK3A HGNC:4616 glycogen synthase kinase 3 alpha P49840 Cytoplasm (GO:0005737); Centrosome (GO:0005813) 12675919,17139249 nucleus 20 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms GSK3B HGNC:4617 glycogen synthase kinase 3 beta P49841 Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813) 17081983,17081983/12048243,17139249,12048243,17139249 nucleus 19 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms GSKIP HGNC:20343 GSK3B interacting protein Q9P0R6 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eumetazoa GSN HGNC:4620 gelsolin P06396 Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Mitochondrion (GO:0005739); Cytoskeleton (GO:0005856) 3020431,10329371,16188874,10809769,15561729 cytoplasm 93 0 cytoplasm. mitochondrion. secreted multiple Bilateria Eukaryota Eukaryota GSPT1 HGNC:4621 G1 to S phase transition 1 P15170 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 12865429,12865429 cytoplasm 28 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Cell.Organisms GSPT2 HGNC:4622 G1 to S phase transition 2 Q8IYD1 Cytoplasm (Probable). Cytoplasm (GO:0005737) 12354098 cytoplasm 26 0 cytoplasm cytoplasm Eukaryota Eukaryota NA GSR HGNC:4623 glutathione reductase P00390 Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 7663973,7663973 mitochondrion 32 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms GSS HGNC:4624 glutathione synthetase P48637 mitochondrion 31 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms GSTA1 HGNC:4626 glutathione S-transferase alpha 1 P08263 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10053036,8598105 cytoplasm 100 0 cytoplasm. secreted multiple NA NA Cell.Organisms GSTA2 HGNC:4627 glutathione S-transferase alpha 2 P09210 Cytoplasm. Cytoplasm (GO:0005737) 3901925 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms GSTA3 HGNC:4628 glutathione S-transferase alpha 3 Q16772 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms GSTA4 HGNC:4629 glutathione S-transferase alpha 4 O15217 Cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11368510,11884396 cytoplasm 100 0 cytoplasm. mitochondrion multiple Deuterostomia Eukaryota Cell.Organisms GSTA5 HGNC:19662 glutathione S-transferase alpha 5 Q7RTV2 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10676639 cytoplasm 88 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms GSTCD HGNC:25806 glutathione S-transferase, C-terminal domain containing Q8NEC7 nucleus 17 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms GSTK1 HGNC:16906 glutathione S-transferase kappa 1 Q9Y2Q3 Peroxisome. Mitochondrion (GO:0005739);Peroxisome (GO:0005777) 14742434,12720545/14742434 peroxisome 100 0 mitochondrion. peroxisome multiple Euteleostomi Cell.Organisms Cell.Organisms GSTM1 HGNC:4632 glutathione S-transferase mu 1 P09488 Cytoplasm. Cytoplasm (GO:0005737) 2468363,8824514 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GSTM2 HGNC:4634 glutathione S-transferase mu 2 (muscle) P28161 Cytoplasm. Cytoplasm (GO:0005737) 10676639 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GSTM3 HGNC:4635 glutathione S-transferase mu 3 (brain) P21266 Cytoplasm. Cytoplasm (GO:0005737) 8824514 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms GSTM4 HGNC:4636 glutathione S-transferase mu 4 Q03013 Cytoplasm. Cytoplasm (GO:0005737) 8284940 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GSTM5 HGNC:4637 glutathione S-transferase mu 5 P46439 Cytoplasm. Cytoplasm (GO:0005737) 11684093 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GSTO1 HGNC:13312 glutathione S-transferase omega 1 P78417 Cytoplasm, cytosol. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11457926,11457926,11457926 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms GSTO2 HGNC:23064 glutathione S-transferase omega 2 Q9H4Y5 cytoplasm 55 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GSTP1 HGNC:4638 glutathione S-transferase pi 1 P09211 Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino-acids function as un uncleaved transit peptide, and arginine residues within it are crucial for motochondrial localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11726546,12725062,2625719,2468363,1880950,2625719,15598749 cytoplasm 18 0 cytoplasm. mitochondrion. nucleus multiple Mammalia Eukaryota Cell.Organisms GSTT1 HGNC:4641 glutathione S-transferase theta 1 P30711 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11884241,11884241 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms GSTT2 HGNC:4642 glutathione S-transferase theta 2 P0CG29 Cytoplasm. Cytoplasm (GO:0005737) 8617495,9037717 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms GSTT2B HGNC:33437 glutathione S-transferase theta 2B (gene/pseudogene) P0CG30 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms GSTZ1 HGNC:4643 glutathione S-transferase zeta 1 O43708 Cytoplasm (By similarity). cytoplasm 82 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GSX1 HGNC:20374 GS homeobox 1 Q9H4S2 Nucleus (By similarity). Nucleus (GO:0005634) 11731616 nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota GSX2 HGNC:24959 GS homeobox 2 Q9BZM3 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 86 0 nucleus nucleus Theria Deuterostomia Eukaryota GTDC1 HGNC:20887 glycosyltransferase-like domain containing 1 Q4AE62 Integral to membrane (GO:0016021) 15068588 cytoplasm 38 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms GTF2A1 HGNC:4646 general transcription factor IIA, 1, 19/37kDa P52655 Nucleus. Kinetochore (GO:0000776); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11780067,,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota GTF2A1L HGNC:30727 general transcription factor IIA, 1-like Q9UNN4 Nucleus. Nucleus (GO:0005634) 10364255,12107178 nucleus 100 0 nucleus nucleus NA NA Eukaryota GTF2A2 HGNC:4647 general transcription factor IIA, 2, 12kDa P52657 Nucleus. Nucleus (GO:0005634) 7958900,7724559,7958899,8224848 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota GTF2B HGNC:4648 general transcription factor IIB Q00403 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) 10409729,15635413,11780067 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms GTF2E1 HGNC:4650 general transcription factor IIE, polypeptide 1, alpha 56kDa P29083 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776) 11416139,9418848,2026628,2251258,3029109,11780067 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota GTF2E2 HGNC:4651 general transcription factor IIE, polypeptide 2, beta 34kDa P29084 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776) 11416139,9418848,2026628,2251258,3029109,11780067 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota GTF2F1 HGNC:4652 general transcription factor IIF, polypeptide 1, 74kDa P35269 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) 10567562,15635413,11780067 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa GTF2F2 HGNC:4653 general transcription factor IIF, polypeptide 2, 30kDa P13984 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10454543,15635413 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota GTF2H1 HGNC:4655 general transcription factor IIH, polypeptide 1, 62kDa P32780 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12453423,12453423 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota GTF2H2 HGNC:4656 general transcription factor IIH, polypeptide 2, 44kDa Q13888 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA GTF2H2C HGNC:31394 GTF2H2 family member C Q6P1K8 Nucleus (By similarity). nucleus 99 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GTF2H3 HGNC:4657 general transcription factor IIH, polypeptide 3, 34kDa Q13889 Nucleus. Nucleus (GO:0005634) 10673506,7724549 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GTF2H4 HGNC:4658 general transcription factor IIH, polypeptide 4, 52kDa Q92759 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776) 9118947,11780067 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA GTF2H5 HGNC:21157 general transcription factor IIH, polypeptide 5 Q6ZYL4 Nucleus. Nucleus (GO:0005634) 15220921 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota NA GTF2I HGNC:4659 general transcription factor IIi P78347 Cytoplasm. Nucleus. Note=Colocalizes with BTK in the cytoplasm. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 17081983/12082086,10373551,15635413,12082086,10373551 nucleus 42 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Craniata GTF2IRD1 HGNC:4661 GTF2I repeat domain containing 1 Q9UHL9 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10642537,10573005,12475981,11438732/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Mammalia Deuterostomia NA GTF2IRD2 HGNC:30775 GTF2I repeat domain containing 2 Q86UP8 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Bilateria Opisthokonta GTF2IRD2B HGNC:33125 GTF2I repeat domain containing 2B Q6EKJ0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15100712,15100712 nucleus 100 0 cytoplasm. nucleus multiple Theria Bilateria Opisthokonta GTF3A HGNC:4662 general transcription factor IIIA Q92664 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2912980,8610146 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota GTF3C1 HGNC:4664 general transcription factor IIIC, polypeptide 1, alpha 220kDa Q12789 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 8164661,1447193/17081983 nucleus 100 2 nucleus nucleus Deuterostomia Bilateria Metazoa GTF3C2 HGNC:4665 general transcription factor IIIC, polypeptide 2, beta 110kDa Q8WUA4 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota GTF3C3 HGNC:4666 general transcription factor IIIC, polypeptide 3, 102kDa Q9Y5Q9 Nucleus. Nucleus (GO:0005634) 11965497 nucleus 100 1 nucleus nucleus Eukaryota Eukaryota Cell.Organisms GTF3C4 HGNC:4667 general transcription factor IIIC, polypeptide 4, 90kDa Q9UKN8 Nucleus. Nucleus (GO:0005634) none,17081983 nucleus 100 0 nucleus nucleus Chordata Chordata Eumetazoa GTF3C5 HGNC:4668 general transcription factor IIIC, polypeptide 5, 63kDa Q9Y5Q8 Nucleus. Nucleus (GO:0005634) 10373544 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota GTF3C6 HGNC:20872 general transcription factor IIIC, polypeptide 6, alpha 35kDa Q969F1 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa GTPBP1 HGNC:4669 GTP binding protein 1 O00178 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10938096 cytoplasm 97 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GTPBP10 HGNC:25106 GTP-binding protein 10 (putative) A4D1E9 Nucleus, nucleolus. Chromosome. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms GTPBP2 HGNC:4670 GTP binding protein 2 Q9BX10 cytoplasm 40 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms GTPBP3 HGNC:14880 GTP binding protein 3 (mitochondrial) Q969Y2 Mitochondrion. Mitochondrion (GO:0005739) 12370316,14680828 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GTPBP4 HGNC:21535 GTP binding protein 4 Q9BZE4 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Ribosome (GO:0005840) 11316846,15635413,11790298,15561729 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms GTPBP6 HGNC:30189 GTP binding protein 6 (putative) O43824 cytoplasm 55 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms GTPBP8 HGNC:25007 GTP-binding protein 8 (putative) Q8N3Z3 mitochondrion 13 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GTSCR1 HGNC:18406 Gilles de la Tourette syndrome chromosome region, candidate 1 Q86UQ5 Membrane; Single-pass membrane protein (Potential). secreted 40 1 secreted secreted NA NA Eutheria GTSE1 HGNC:13698 G-2 and S-phase expressed 1 Q9NYZ3 Cytoplasm, cytoskeleton. Note=Associated with microtubules. Cytoplasm (GO:0005737) 10974554 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Euteleostomi GTSF1 HGNC:26565 gametocyte specific factor 1 Q8WW33 cytoplasm 40 0 cytoplasm cytoplasm Deuterostomia Eukaryota Metazoa GTSF1L HGNC:16198 gametocyte specific factor 1-like Q9H1H1 cytoplasm 24 0 cytoplasm cytoplasm Eutheria Bilateria Metazoa GUCA1A HGNC:4678 guanylate cyclase activator 1A (retina) P43080 Membrane; Lipid-anchor. mitochondrion membrane 16 0 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Cell.Organisms GUCA1B HGNC:4679 guanylate cyclase activator 1B (retina) Q9UMX6 Cell membrane. Note=Membranes of outer segment. plasma membrane 17 0 n/a n/a Euteleostomi Euteleostomi Cell.Organisms GUCA1C HGNC:4680 guanylate cyclase activator 1C O95843 cytoplasm 20 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms GUCA2A HGNC:4682 guanylate cyclase activator 2A (guanylin) Q02747 Secreted. Extracellular (GO:0005576) 7892222 secreted 100 0 secreted secreted Human Euteleostomi Euteleostomi GUCA2B HGNC:4683 guanylate cyclase activator 2B (uroguanylin) Q16661 Secreted. Extracellular (GO:0005576) 9268639,9328941 secreted 100 0 secreted secreted Theria Theria Euteleostomi GUCD1 HGNC:14237 guanylyl cyclase domain containing 1 Q96NT3 cytoplasm 26 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota GUCY1A2 HGNC:4684 guanylate cyclase 1, soluble, alpha 2 P33402 Cytoplasm. Cytoplasm (GO:0005737) 11158065 cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms GUCY1A3 HGNC:4685 guanylate cyclase 1, soluble, alpha 3 Q02108 Cytoplasm. Cytoplasm (GO:0005737) ,17873020, cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms GUCY1B3 HGNC:4687 guanylate cyclase 1, soluble, beta 3 Q02153 Cytoplasm. Cytoplasm (GO:0005737) 10977868 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms GUCY2C HGNC:4688 guanylate cyclase 2C (heat stable enterotoxin receptor) P25092 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. Plasma membrane (GO:0005886) 1680854,10601865 cytoplasm 24 1 endoplasmic reticulum membrane. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms GUCY2D HGNC:4689 guanylate cyclase 2D, membrane (retina-specific) Q02846 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9698373 cytoplasm 28 2 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms GUCY2F HGNC:4691 guanylate cyclase 2F, retinal P51841 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7777544 cytoplasm 30 1 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms GUF1 HGNC:25799 GUF1 GTPase homolog (S. cerevisiae) Q8N442 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity). mitochondrion 36 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms GUK1 HGNC:4693 guanylate kinase 1 Q16774 Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 2164269,6260205 cytoplasm 18 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms GULP1 HGNC:18649 GULP, engulfment adaptor PTB domain containing 1 Q9UBP9 Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa GUSB HGNC:4696 glucuronidase, beta P08236 Lysosome. Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 14502216,10562416,8537326,14718574 secreted 14 0 endoplasmic reticulum. golgi apparatus. lysosome. secreted multiple Bilateria Cell.Organisms Cell.Organisms GVQW1 HGNC:31424 GVQW motif containing 1 Q8N7I0 secreted 57 0 secreted secreted NA NA Opisthokonta GXYLT1 HGNC:27482 glucoside xylosyltransferase 1 Q4G148 Membrane; Single-pass type II membrane protein (Potential). endoplasmic reticulum membrane 17 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Cell.Organisms GXYLT2 HGNC:33383 glucoside xylosyltransferase 2 A0PJZ3 Membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 7 0 golgi apparatus membrane golgi apparatus membrane Chordata Chordata Cell.Organisms GYG1 HGNC:4699 glycogenin 1 P46976 cytoplasm 20 0 cytoplasm cytoplasm Bilateria Opisthokonta Cell.Organisms GYG2 HGNC:4700 glycogenin 2 O15488 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Opisthokonta Cell.Organisms GYLTL1B HGNC:16522 glycosyltransferase-like 1B Q8N3Y3 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 61 0 golgi apparatus membrane golgi apparatus membrane Deuterostomia Eukaryota Cell.Organisms GYPA HGNC:4702 glycophorin A (MNS blood group) P02724 Cell membrane; Single-pass type I membrane protein. Note=Appears to be colocalized with SLC4A1. Plasma membrane (GO:0005886) 7622054,3345758,1560003,8245024 plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Mammalia Eutheria GYPB HGNC:4703 glycophorin B (MNS blood group) P06028 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 3571235 plasma membrane 100 1 plasma membrane plasma membrane NA NA Primates GYPC HGNC:4704 glycophorin C (Gerbich blood group) P04921 Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1. Plasma membrane (GO:0005886) 2416746,8219208,1991173 plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Deuterostomia GYPE HGNC:4705 glycophorin E (MNS blood group) P15421 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7521873,2295603 plasma membrane 68 1 plasma membrane plasma membrane Homininae Homininae Primates GYS1 HGNC:4706 glycogen synthase 1 (muscle) P13807 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 11251056,10924520,17081983,10924520,17081983,15561729 cytoplasm 39 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms GYS2 HGNC:4707 glycogen synthase 2 (liver) P54840 Cytoplasm (GO:0005737) 2169698,1898724 cytoplasm 44 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms GZF1 HGNC:15808 GDNF-inducible zinc finger protein 1 Q9H116 Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Nuclear localization depends upon NCL. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14522971,14522971 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota GZMA HGNC:4708 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) P12544 Isoform alpha: Secreted. Cytoplasmic granule. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9256474,9531325 secreted 24 0 cytoplasm. secreted multiple Tetrapoda Euteleostomi Cell.Organisms GZMB HGNC:4709 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) P10144 Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8156655,8156655 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms GZMH HGNC:4710 granzyme H (cathepsin G-like 2, protein h-CCPX) P20718 Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes. Endosome (GO:0005768); Nucleus (GO:0005634) 10521426,18495788 cytoplasm 100 0 endosome. nucleus multiple Human Eutheria Cell.Organisms GZMK HGNC:4711 granzyme K (granzyme 3; tryptase II) P49863 Secreted. Cytoplasmic granule. Secretory granule (GO:0030141) 8656064 secreted 27 0 secreted secreted Eutheria Euteleostomi Cell.Organisms GZMM HGNC:4712 granzyme M (lymphocyte met-ase 1) P51124 Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes. Secretory granule (GO:0030141) 8245461 secreted 22 0 secreted secreted Human Euteleostomi Cell.Organisms H1F0 HGNC:4714 H1 histone family, member 0 P07305 Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9770363,7511470,9770363 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Opisthokonta Eukaryota H1FNT HGNC:24893 H1 histone family, member N, testis-specific Q75WM6 Nucleus (By similarity). Chromosome (By similarity). Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole (By similarity). Nucleus (GO:0005634) 15710904 nucleus 46 0 nucleus nucleus Eutheria Eutheria Eutheria H1FOO HGNC:18463 H1 histone family, member O, oocyte-specific Q8IZA3 Cytoplasm (By similarity). Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12711322,15371275,14729479,14729478,15371275 nucleus 46 0 cytoplasm. nucleus multiple Eutheria Eutheria Bilateria H1FX HGNC:4722 H1 histone family, member X Q92522 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 1879604,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Tetrapoda Tetrapoda Eumetazoa H2AFB1 HGNC:22516 H2A histone family, member B1 P0C5Y9 Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. Nucleus (GO:0005634) 11266453 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria NA H2AFB2 HGNC:18298 H2A histone family, member B2 P0C5Z0 Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. Nucleus (GO:0005634) 11266453 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria NA H2AFB3 HGNC:14455 H2A histone family, member B3 P0C5Z0 Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies. Nucleus (GO:0005634) 11266453 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria NA H2AFJ HGNC:14456 H2A histone family, member J Q9BTM1 Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634) nucleus 97 0 nucleus nucleus NA NA Eukaryota H2AFV HGNC:20664 H2A histone family, member V Q71UI9 Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota H2AFX HGNC:4739 H2A histone family, member X P16104 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) 16377563,15364958,12447390,15733840 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota H2AFY HGNC:4740 H2A histone family, member Y O75367 Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. Centrosome (GO:0005813); Nucleus (GO:0005634); Chromosome (GO:0005694);Nucleus (GO:0005634) 12082075,,16210244,15561729,12419249,,,17158748,/11262398 nucleus 100 1 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms H2AFY2 HGNC:14453 H2A histone family, member Y2 Q9P0M6 Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. Nucleus (GO:0005634) 11262398 nucleus 100 1 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms H2AFZ HGNC:4741 H2A histone family, member Z P0C0S5 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota H2BFM HGNC:27867 H2B histone family, member M P0C1H6 Nucleus. Chromosome. nucleus 100 0 nucleus nucleus Human Human NA H2BFWT HGNC:27252 H2B histone family, member W, testis-specific Q7Z2G1 Nucleus membrane. Chromosome. Nucleus (GO:0005634) 15475252 nucleus 58 0 nucleus nucleus Eutheria Eutheria NA H3F3A HGNC:4764 H3 histone, family 3A P84243 Nucleus. Chromosome. Nucleus (GO:0005634) 12909349 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota H3F3B HGNC:4765 H3 histone, family 3B (H3.3B) P84243 Nucleus. Chromosome. Nucleus (GO:0005634) 12909349 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota H3F3C HGNC:33164 H3 histone, family 3C Q6NXT2 Nucleus. Chromosome. nucleus 100 0 nucleus nucleus Human Human Eukaryota H6PD HGNC:4795 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) O95479 Endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 4169027,10497882 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum multiple Euteleostomi Deuterostomia Cell.Organisms HAAO HGNC:4796 3-hydroxyanthranilate 3,4-dioxygenase P46952 Cytoplasm. Cytoplasm (GO:0005737) 7514594 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms HABP2 HGNC:4798 hyaluronan binding protein 2 Q14520 Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. Extracellular (GO:0005576) 8827452 secreted 100 0 secreted secreted Chordata Cell.Organisms Cell.Organisms HABP4 HGNC:17062 hyaluronan binding protein 4 Q5JVS0 Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 1310832,10887182,14699138,1310832,14699138,1310832 cytoplasm 49 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria HACE1 HGNC:21033 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Q8IYU2 Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 15254018,15254018 cytoplasm 29 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Cell.Organisms HACL1 HGNC:17856 2-hydroxyacyl-CoA lyase 1 Q9UJ83 Peroxisome. Peroxisome (GO:0005777) 10468558,15561729 peroxisome 100 0 peroxisome peroxisome Cell.Organisms Cell.Organisms Cell.Organisms HADH HGNC:4799 hydroxyacyl-CoA dehydrogenase Q16836 Mitochondrion matrix. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730) 8687463,10760475,10231530,11559359,11559359,15635413 mitochondrion 100 0 endoplasmic reticulum. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HADHA HGNC:4801 hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit P40939 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 11390422,15598749,17081983 mitochondrion 100 0 mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms HADHB HGNC:4803 hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit P55084 Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Endoplasmic reticulum. Mitochondrion (GO:0005739) 1550553,15598749 peroxisome 25 0 endoplasmic reticulum. mitochondrion multiple Chordata Cell.Organisms Cell.Organisms HAGH HGNC:4805 hydroxyacylglutathione hydrolase Q16775 Isoform 1: Mitochondrion matrix. Isoform 2: Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 3382669,3382669 cytoplasm 43 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms HAGHL HGNC:14177 hydroxyacylglutathione hydrolase-like Q6PII5 cytoplasm 31 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms HAL HGNC:4806 histidine ammonia-lyase P42357 Cytoplasm (GO:0005737) 8530107 cytoplasm 58 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms HAMP HGNC:15598 hepcidin antimicrobial peptide P81172 Secreted. Extracellular (GO:0005576) 11034317 secreted 100 0 secreted secreted Theria Theria Mammalia HAND1 HGNC:4807 heart and neural crest derivatives expressed 1 O96004 Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus (By similarity). Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1182795,11802795 nucleus 91 0 cytoplasm. nucleus multiple Chordata Chordata Metazoa HAND2 HGNC:4808 heart and neural crest derivatives expressed 2 P61296 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 54 0 nucleus nucleus Tetrapoda Bilateria Metazoa HAO1 HGNC:4809 hydroxyacid oxidase (glycolate oxidase) 1 Q9UJM8 Peroxisome. Peroxisome (GO:0005777) 10777549 peroxisome 100 0 peroxisome peroxisome Cell.Organisms Cell.Organisms Cell.Organisms HAO2 HGNC:4810 hydroxyacid oxidase 2 (long chain) Q9NYQ3 Peroxisome. Peroxisome (GO:0005777); Cytoplasm (GO:0005737) 10777549,10777549 peroxisome 100 0 cytoplasm. peroxisome multiple Cell.Organisms Cell.Organisms Cell.Organisms HAP1 HGNC:4812 huntingtin-associated protein 1 P54257 Endosome (GO:0005768); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 12021262,9742138,9742138,9742138 mitochondrion 12 0 cytoplasm. endoplasmic reticulum. endosome. mitochondrion multiple Eutheria Eutheria NA HAPLN1 HGNC:2380 hyaluronan and proteoglycan link protein 1 P10915 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 12429048 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa HAPLN2 HGNC:17410 hyaluronan and proteoglycan link protein 2 Q9GZV7 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11817897 secreted 90 0 secreted secreted Euteleostomi Euteleostomi Chordata HAPLN3 HGNC:21446 hyaluronan and proteoglycan link protein 3 Q96S86 Secreted, extracellular space, extracellular matrix (By similarity). secreted 45 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa HAPLN4 HGNC:31357 hyaluronan and proteoglycan link protein 4 Q86UW8 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 12663660 secreted 40 0 secreted secreted Theria Euteleostomi Eumetazoa HARBI1 HGNC:26522 harbinger transposase derived 1 Q96MB7 Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus. secreted 17 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota HARS HGNC:4816 histidyl-tRNA synthetase P12081 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8929351,2023220,8929351,2023220 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HARS2 HGNC:4817 histidyl-tRNA synthetase 2, mitochondrial P49590 Mitochondrion matrix (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9445076,17081983,9445076,17081983 cytoplasm 71 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HAS1 HGNC:4818 hyaluronan synthase 1 Q92839 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 9169154,3099751 plasma membrane 6 7 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms HAS2 HGNC:4819 hyaluronan synthase 2 Q92819 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 9169154 plasma membrane 8 7 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms HAS3 HGNC:4820 hyaluronan synthase 3 O00219 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 9169154 plasma membrane 7 7 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms HAT1 HGNC:4821 histone acetyltransferase 1 O14929 Isoform A: Nucleus matrix. Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9427644,11585814 nucleus 45 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota HAUS1 HGNC:25174 HAUS augmin-like complex, subunit 1 Q96CS2 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic asters and is highly punctate on the microtubule array. During later stages of mitosis, remains on the spindle but is not present at the interzone, and is finally observed at the microtubule bundles proximal to the midbody, clearly excluded from the midbody. In contrast, does not colocalize with the tubulin cytoskeleton in interphase cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Cytoskeleton (GO:0005856); Centrosome (GO:0005813); Plasma membrane (GO:0005886) 15082789,15082789,15082789 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota HAUS2 HGNC:25530 HAUS augmin-like complex, subunit 2 Q9NVX0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. Centrosome (GO:0005813) 14654843 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria HAUS3 HGNC:28719 HAUS augmin-like complex, subunit 3 Q68CZ6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota HAUS4 HGNC:20163 HAUS augmin-like complex, subunit 4 Q9H6D7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Holozoa HAUS5 HGNC:29130 HAUS augmin-like complex, subunit 5 O94927 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. cytoplasm 100 0 cytoplasm cytoplasm NA NA Bilateria HAUS6 HGNC:25948 HAUS augmin-like complex, subunit 6 Q7Z4H7 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Opisthokonta HAUS7 HGNC:32979 HAUS augmin-like complex, subunit 7 Q99871 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia NA HAUS8 HGNC:30532 HAUS augmin-like complex, subunit 8 Q9BT25 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Eumetazoa HAVCR1 HGNC:17866 hepatitis A virus cellular receptor 1 Q96D42 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9658108,12138159 plasma membrane 24 1 plasma membrane. secreted multiple Eutheria Euteleostomi Euteleostomi HAVCR2 HGNC:18437 hepatitis A virus cellular receptor 2 Q8TDQ0 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 15325803,11823861 plasma membrane 15 1 plasma membrane plasma membrane Mammalia Mammalia Euteleostomi HAX1 HGNC:16915 HCLS1 associated protein X-1 O00165 Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle (By similarity). Sarcoplasmic reticulum (By similarity). Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Nuclear membrane (GO:0005635); Cytoplasm (GO:0005737); Clathrin-coated vesicle (GO:0030136); Golgi vesicle (GO:0005798); Lysosome (GO:0005764) 9058808,16227293,15598749,9058808,10760273,9058808,10760273,16227293,15159385,15159385,15159385 nucleus 57 0 cytoplasm. endoplasmic reticulum. golgi apparatus. lysosome. mitochondrion. nucleus membrane multiple Mammalia Deuterostomia Bilateria HBA1 HGNC:4823 hemoglobin, alpha 1 P69905 cytoplasm 11 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms HBA2 HGNC:4824 hemoglobin, alpha 2 P69905 cytoplasm 11 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms HBB HGNC:4827 hemoglobin, beta P68871 Extracellular (GO:0005576) 16188874,12488461 secreted 17 0 secreted secreted NA NA Cell.Organisms HBD HGNC:4829 hemoglobin, delta P02042 secreted 13 0 secreted secreted NA NA Cell.Organisms HBE1 HGNC:4830 hemoglobin, epsilon 1 P02100 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9220539,9220539 secreted 12 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms HBEGF HGNC:3059 heparin-binding EGF-like growth factor Q99075 Heparin-binding EGF-like growth factor: Secreted, extracellular space. Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cell surface (GO:0009986) 12149405,12149405,15389565,15389565,8194524 plasma membrane 12 1 cytoplasm. nucleus. plasma membrane. secreted multiple Amniota Euteleostomi Euteleostomi HBG1 HGNC:4831 hemoglobin, gamma A P69891 secreted 17 0 secreted secreted NA NA Cell.Organisms HBG2 HGNC:4832 hemoglobin, gamma G P69892 secreted 17 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms HBM HGNC:4826 hemoglobin, mu Q6B0K9 cytoplasm 10 0 cytoplasm cytoplasm Homininae Eutheria Cell.Organisms HBP1 HGNC:23200 HMG-box transcription factor 1 O60381 Nucleus. Nucleus (GO:0005634) 10562551,15235594 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota HBQ1 HGNC:4833 hemoglobin, theta 1 P09105 cytoplasm 14 0 cytoplasm cytoplasm Human Eutheria Cell.Organisms HBS1L HGNC:4834 HBS1-like (S. cerevisiae) Q9Y450 Cytoplasm (GO:0005737) cytoplasm 28 0 cytoplasm cytoplasm Euarchontoglires Cell.Organisms Cell.Organisms HBZ HGNC:4835 hemoglobin, zeta P02008 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms HCAR1 HGNC:4532 hydroxycarboxylic acid receptor 1 Q9BXC0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Metazoa HCAR2 HGNC:24827 hydroxycarboxylic acid receptor 2 Q8TDS4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12522134 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa HCAR3 HGNC:16824 hydroxycarboxylic acid receptor 3 P49019 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane NA NA Metazoa HCCS HGNC:4837 holocytochrome c synthase P53701 Mitochondrion inner membrane (Potential). Mitochondrion (GO:0005739) 11827457 nucleus 23 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota HCFC1 HGNC:4839 host cell factor C1 (VP16-accessory protein) P51610 Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 17081983,17081983/11340173,15705566,12235138,15705566,15598749 cytoplasm 13 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota NA HCFC1R1 HGNC:21198 host cell factor C1 regulator 1 (XPO1 dependent) Q9NWW0 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12235138,12235138 nucleus 61 0 cytoplasm. nucleus multiple Theria Theria Craniata HCFC2 HGNC:24972 host cell factor C2 Q9Y5Z7 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10196288,15199122,10196288 plasma membrane 25 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms HCG22 HGNC:27780 HLA complex group 22 E2RYF7 Secreted (Potential). secreted 10 0 secreted secreted NA NA NA HCK HGNC:4840 hemopoietic cell kinase P08631 Isoform 1: Lysosome. Membrane; Lipid-anchor. Cell projection, podosome membrane; Lipid-anchor. Cytoplasm, cytosol. Isoform 2: Cell membrane; Lipid-anchor. Membrane, caveola; Lipid-anchor. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasmic vesicle. Lysosome. Nucleus. Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Lysosome (GO:0005764); Nucleus (GO:0005634) 7791757,7791757,10967098,17081983 plasma membrane 30 0 cytoplasm. golgi apparatus. lysosome. nucleus multiple Deuterostomia Bilateria Cell.Organisms HCLS1 HGNC:4844 hematopoietic cell-specific Lyn substrate 1 P14317 Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9104825,12534372,9104825,15166239 cytoplasm 39 0 cytoplasm. mitochondrion. nucleus multiple Theria Euteleostomi Eukaryota HCN1 HGNC:4845 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 O60741 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12598605 cytoplasm 18 7 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms HCN2 HGNC:4846 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 Q9UL51 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12928435 plasma membrane 32 7 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms HCN3 HGNC:19183 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 Q9P1Z3 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 9634236 cytoplasm 18 6 cytoplasm cytoplasm Deuterostomia Eukaryota NA HCN4 HGNC:16882 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 Q9Y3Q4 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10228147 secreted 21 7 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms HCRT HGNC:4847 hypocretin (orexin) neuropeptide precursor O43612 Rough endoplasmic reticulum (By similarity). Cytoplasmic vesicle (By similarity). Cell junction, synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity). Extracellular (GO:0005576) 9491897 endoplasmic reticulum 77 0 secreted secreted Theria Euteleostomi Euteleostomi HCRTR1 HGNC:4848 hypocretin (orexin) receptor 1 O43613 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12690115 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Mammalia Eumetazoa HCRTR2 HGNC:4849 hypocretin (orexin) receptor 2 O43614 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9491897 plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Deuterostomia Eumetazoa HCST HGNC:16977 hematopoietic cell signal transducer Q9UBK5 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10426994 secreted 85 1 plasma membrane plasma membrane Euarchontoglires Eutheria Boreoeutheria HDAC1 HGNC:4852 histone deacetylase 1 Q13547 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) ,10846170,17245431,16959611,16543236,19059367,11013263,16565076,,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms HDAC10 HGNC:18128 histone deacetylase 10 Q969S8 Cytoplasm. Nucleus. Note=Excluded from the nucleoli. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11726666,11739383,11677242,11726666,11677242 nucleus 23 3 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms HDAC11 HGNC:19086 histone deacetylase 11 Q96DB2 Nucleus. Note=Predominantly nuclear. Nucleus (GO:0005634) 11948178 nucleus 100 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms HDAC2 HGNC:4853 histone deacetylase 2 Q92769 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) ,11779848,17245431,15696166,19059367,11013263,,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms HDAC3 HGNC:4854 histone deacetylase 3 O15379 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) ,9501169,11013263,,9501169/17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms HDAC4 HGNC:14063 histone deacetylase 4 P56524 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11792813,11792813 nucleus 39 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms HDAC5 HGNC:14068 histone deacetylase 5 Q9UQL6 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11081517,10869435,16678093,15060175,11081517,10869435,16678093 nucleus 42 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms HDAC6 HGNC:14064 histone deacetylase 6 Q9UBN7 Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12391164,12024216 nucleus 27 0 cytoplasm. nucleus multiple Mammalia Cell.Organisms NA HDAC7 HGNC:14067 histone deacetylase 7 Q8WUI4 Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrial intermembrane space (GO:0005758) 11466315,11262386,15623513,16956611,11466315,11262386,16956611,15364908 nucleus 28 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms HDAC8 HGNC:13315 histone deacetylase 8 Q9BY41 Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. Nucleus (GO:0005634) 10748112,10922473 nucleus 30 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms NA HDAC9 HGNC:14065 histone deacetylase 9 Q9UKV0 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12590135,17081983,12590135 nucleus 94 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms HDC HGNC:4855 histidine decarboxylase P19113 Cytoplasm (GO:0005737) 9865502 nucleus 28 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms HDDC2 HGNC:21078 HD domain containing 2 Q7Z4H3 cytoplasm 43 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms HDDC3 HGNC:30522 HD domain containing 3 Q8N4P3 cytoplasm 64 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms HDGF HGNC:4856 hepatoma-derived growth factor P51858 Cytoplasm. Nucleus. Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 14535987,17081983,12816346,7929202,14535987,17081983 nucleus 62 0 cytoplasm. nucleus. secreted multiple Tetrapoda Euteleostomi Eukaryota HDGFL1 HGNC:21095 hepatoma derived growth factor-like 1 Q5TGJ6 nucleus 52 0 nucleus nucleus Catarrhini Eutheria Eukaryota HDHD1 HGNC:16818 haloacid dehalogenase-like hydrolase domain containing 1 Q08623 cytoplasm 55 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms HDHD2 HGNC:25364 haloacid dehalogenase-like hydrolase domain containing 2 Q9H0R4 mitochondrion 10 0 mitochondrion mitochondrion Chordata Cell.Organisms Cell.Organisms HDHD3 HGNC:28171 haloacid dehalogenase-like hydrolase domain containing 3 Q9BSH5 cytoplasm 50 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms HDLBP HGNC:4857 high density lipoprotein binding protein Q00341 Cytoplasm. Nucleus. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleolus (GO:0005730);Plasma membrane (GO:0005886) 8605996,10657246,15723802,15109574,17081983,3034894,11284697,12488461,12543931,8477745,8605996,11284697,15723802,15109574,17081983,15109574,15109574/1318310 cytoplasm 84 0 cytoplasm. nucleus. secreted multiple Opisthokonta Opisthokonta Eukaryota HDX HGNC:26411 highly divergent homeobox Q7Z353 Nucleus (By similarity). nucleus 92 0 nucleus nucleus Tetrapoda Euteleostomi Chordata HEATR1 HGNC:25517 HEAT repeat containing 1 Q9H583 Nucleus, nucleolus. nucleus 100 2 nucleus nucleus Opisthokonta Eukaryota Eukaryota HEATR2 HGNC:26013 HEAT repeat containing 2 Q86Y56 Cytoplasm. Note=Observed only in the cytoplasm of ciliated airway epithelial cells. Absent from cilia. cytoplasm 100 1 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota HEATR3 HGNC:26087 HEAT repeat containing 3 Q7Z4Q2 nucleus 82 1 nucleus nucleus Euteleostomi Eukaryota Eukaryota HEATR4 HGNC:16761 HEAT repeat containing 4 Q86WZ0 nucleus 61 0 nucleus nucleus Mammalia Deuterostomia Cell.Organisms HEATR5A HGNC:20276 HEAT repeat containing 5A Q86XA9 golgi apparatus 16 4 golgi apparatus golgi apparatus Opisthokonta Eukaryota Eukaryota HEATR5B HGNC:29273 HEAT repeat containing 5B Q9P2D3 golgi apparatus 13 4 golgi apparatus golgi apparatus Opisthokonta Eukaryota Eukaryota HEATR6 HGNC:24076 HEAT repeat containing 6 Q6AI08 nucleus 58 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota HEBP1 HGNC:17176 heme binding protein 1 Q9NRV9 Cytoplasm. Cytoplasm (GO:0005737) 12413491 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Cell.Organisms HEBP2 HGNC:15716 heme binding protein 2 Q9Y5Z4 Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10640688,10640688 cytoplasm 11 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Eukaryota Cell.Organisms HECA HGNC:21041 headcase homolog (Drosophila) Q9UBI9 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa HECTD1 HGNC:20157 HECT domain containing E3 ubiquitin protein ligase 1 Q9ULT8 cytoplasm 26 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms HECTD2 HGNC:26736 HECT domain containing E3 ubiquitin protein ligase 2 Q5U5R9 nucleus 22 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota HECTD3 HGNC:26117 HECT domain containing E3 ubiquitin protein ligase 3 Q5T447 Cytoplasm, perinuclear region (By similarity). cytoplasm 97 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota HECTD4 HGNC:26611 HECT domain containing E3 ubiquitin protein ligase 4 Q9Y4D8 Membrane; Single-pass membrane protein (Potential). cytoplasm 10 3 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota HECW1 HGNC:22195 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Q76N89 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14684739,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota HECW2 HGNC:29853 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Q9P2P5 Cytoplasm (By similarity). cytoplasm 68 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota HEG1 HGNC:29227 heart development protein with EGF-like domains 1 Q9ULI3 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction (By similarity). Isoform 2: Secreted (Potential). Integral to membrane (GO:0016021) secreted 26 1 secreted secreted Euteleostomi Euteleostomi Eukaryota HELB HGNC:17196 helicase (DNA) B Q8NG08 Note=Preferentially during S phase, recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment. Nucleus (GO:0005634) nucleus 59 0 nucleus nucleus Tetrapoda Deuterostomia Cell.Organisms HELLS HGNC:4861 helicase, lymphoid-specific Q9NRZ9 Nucleus (By similarity). Note=Closely associated with pericentric heterochromatin (By similarity). Nucleus (GO:0005634) 10910076 nucleus 89 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms HELQ HGNC:18536 helicase, POLQ-like Q8TDG4 Nucleus (GO:0005634) 11751861 nucleus 10 2 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms HELT HGNC:33783 helt bHLH transcription factor A6NFD8 Nucleus (By similarity). Nucleus (GO:0005634) 14764602 nucleus 88 1 nucleus nucleus Theria Euteleostomi Opisthokonta HELZ HGNC:16878 helicase with zinc finger P42694 Nucleus (Probable). Nucleus (GO:0005634) 17000644,17081983 nucleus 21 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms HELZ2 HGNC:30021 helicase with zinc finger 2, transcriptional coactivator Q9BYK8 Nucleus. nucleus 100 0 nucleus nucleus NA NA Cell.Organisms HEMGN HGNC:17509 hemogen Q9BXL5 Nucleus. Nucleus (GO:0005634) 11404085 nucleus 100 0 nucleus nucleus Theria Chordata Mammalia HEMK1 HGNC:24923 HemK methyltransferase family member 1 Q9Y5R4 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms HENMT1 HGNC:26400 HEN1 methyltransferase homolog 1 (Arabidopsis) Q5T8I9 Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Mammalia Cell.Organisms Cell.Organisms HEPACAM HGNC:26361 hepatic and glial cell adhesion molecule Q14CZ8 Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 15917256,15885354,15917256,15885354 plasma membrane 15 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Metazoa HEPACAM2 HGNC:27364 HEPACAM family member 2 A8MVW5 Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation). Integral to membrane (GO:0016021) plasma membrane 17 1 cytoplasm. golgi apparatus membrane multiple Euteleostomi Euteleostomi Eumetazoa HEPH HGNC:4866 hephaestin Q9BQS7 Membrane; Single-pass type I membrane protein (Potential). Basolateral membrane (GO:0016323); Perinuclear region (GO:0048471); Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 16274220,11891802,11891802,11891802 secreted 38 1 cytoplasm. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms HEPHL1 HGNC:30477 hephaestin-like 1 Q6MZM0 Membrane; Single-pass type I membrane protein (Potential). secreted 40 1 secreted secreted Deuterostomia Eukaryota Cell.Organisms HEPN1 HGNC:34400 hepatocellular carcinoma, down-regulated 1 Q6WQI6 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12971969,12971969 cytoplasm 100 0 cytoplasm. nucleus multiple NA NA Homo HERC1 HGNC:4867 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Q15751 Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin- rich surface protrusions. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 9233772,8861955,12650930 cytoplasm 15 2 cytoplasm. golgi apparatus multiple Deuterostomia Eukaryota Cell.Organisms HERC2 HGNC:4868 HECT and RLD domain containing E3 ubiquitin protein ligase 2 O95714 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis. golgi apparatus 32 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA HERC3 HGNC:4876 HECT and RLD domain containing E3 ubiquitin protein ligase 3 Q15034 Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures. Cytoplasm (GO:0005737); Endosome (GO:0005768) 15676274,,18535780, cytoplasm 100 1 cytoplasm. endosome multiple Bilateria Cell.Organisms Cell.Organisms HERC4 HGNC:24521 HECT and RLD domain containing E3 ubiquitin protein ligase 4 Q5GLZ8 Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution. Cytoplasm (GO:0005737) 15676274 cytoplasm 100 1 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms HERC5 HGNC:24368 HECT and RLD domain containing E3 ubiquitin protein ligase 5 Q9UII4 Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S subunit. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10581175,10581175 cytoplasm 100 1 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms HERC6 HGNC:26072 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Q8IVU3 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 15676274 cytoplasm 100 1 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms HERPUD1 HGNC:13744 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Q15011 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10922362,10708769 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane multiple Chordata Chordata Metazoa HERPUD2 HGNC:21915 HERPUD family member 2 Q9BSE4 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 33 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Holozoa HES1 HGNC:5192 hes family bHLH transcription factor 1 Q14469 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,18550849 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Holozoa HES2 HGNC:16005 hes family bHLH transcription factor 2 Q9Y543 Nucleus (By similarity). Nucleus (GO:0005634) 15254753,9570950 nucleus 61 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa HES3 HGNC:26226 hes family bHLH transcription factor 3 Q5TGS1 Nucleus (By similarity). nucleus 60 0 nucleus nucleus Eutheria Euteleostomi Eumetazoa HES4 HGNC:24149 hes family bHLH transcription factor 4 Q9HCC6 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 63 0 nucleus nucleus Deuterostomia Bilateria Metazoa HES5 HGNC:19764 hes family bHLH transcription factor 5 Q5TA89 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 87 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa HES6 HGNC:18254 hes family bHLH transcription factor 6 Q96HZ4 Nucleus (Probable). Nucleus (GO:0005634) 1155198 nucleus 24 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa HES7 HGNC:15977 hes family bHLH transcription factor 7 Q9BYE0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Mammalia Euteleostomi Eumetazoa HESX1 HGNC:4877 HESX homeobox 1 Q9UBX0 Nucleus (Probable). Nucleus (GO:0005634) 11748154 nucleus 48 0 nucleus nucleus Tetrapoda Opisthokonta Eukaryota HEXA HGNC:4878 hexosaminidase A (alpha polypeptide) P06865 Lysosome. Lysosome (GO:0005764) 9217013 vacuole 22 0 lysosome lysosome Bilateria Cell.Organisms Cell.Organisms HEXB HGNC:4879 hexosaminidase B (beta polypeptide) P07686 Lysosome. Lysosome (GO:0005764); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 10591618,11447134,11447134 vacuole 21 0 endoplasmic reticulum. golgi apparatus. lysosome multiple Bilateria Cell.Organisms Cell.Organisms HEXDC HGNC:26307 hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing Q8WVB3 Cytoplasm. Nucleus (By similarity). cytoplasm 25 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms HEXIM1 HGNC:24953 hexamethylene bis-acetamide inducible 1 O94992 Nucleus. Cytoplasm. Note=Binds alpha- importin and is mostly nuclear. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12581153,12119119,12832472,17081983,12581153 nucleus 48 0 cytoplasm. nucleus multiple Theria Bilateria Eumetazoa HEXIM2 HGNC:28591 hexamethylene bis-acetamide inducible 2 Q96MH2 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15994294,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Theria Eumetazoa HEY1 HGNC:4880 hes-related family bHLH transcription factor with YRPW motif 1 Q9Y5J3 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 95 0 nucleus nucleus Euteleostomi Bilateria Metazoa HEY2 HGNC:4881 hes-related family bHLH transcription factor with YRPW motif 2 Q9UBP5 Nucleus (By similarity). Nucleus (GO:0005634) 11486045 nucleus 93 0 nucleus nucleus Chordata Chordata Metazoa HEYL HGNC:4882 hes-related family bHLH transcription factor with YRPW motif-like Q9NQ87 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Amniota Euteleostomi Opisthokonta HFE HGNC:4886 hemochromatosis Q30201 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9162021,9371823,9465039,15056661,9122230,12656741,9122230,10085150 secreted 22 1 cytoplasm. plasma membrane multiple Theria Theria Craniata HFE2 HGNC:4887 hemochromatosis type 2 (juvenile) Q6ZVN8 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886) 16103117 secreted 93 1 plasma membrane plasma membrane Human Human NA HFM1 HGNC:20193 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) A2PYH4 nucleus 15 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms HGD HGNC:4892 homogentisate 1,2-dioxygenase Q93099 cytoplasm 34 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms HGF HGNC:4893 hepatocyte growth factor (hepapoietin A; scatter factor) P14210 Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11929792,11929792,18495663 secreted 31 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Cell.Organisms HGFAC HGNC:4894 HGF activator Q04756 Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. Extracellular (GO:0005576) 9045658,7683665 secreted 100 0 secreted secreted Tetrapoda Chordata Cell.Organisms HGS HGNC:4897 hepatocyte growth factor-regulated tyrosine kinase substrate O14964 Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Endosome (GO:0005768) 9630564,11397816 cytoplasm 23 0 cytoplasm. endosome multiple Bilateria Bilateria Eukaryota HGSNAT HGNC:26527 heparan-alpha-glucosaminide N-acetyltransferase Q68CP4 Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with the lysosomal marker LAMP2. The signal peptide is not cleaved upon translocation into the endoplasmic reticulum; the precursor is probably targeted to the lysosomes via the adapter protein complex-mediated pathway that involves tyrosine- and/or dileucine-based conserved amino acid motifs in the last C-terminus 16-amino acid domain. Lysosome (GO:0005764); Cytosol (GO:0005829) 17033958,16960811,17033958,16960811 plasma membrane 18 11 cytoplasm. lysosome. lysosome membrane multiple Deuterostomia Cell.Organisms Cell.Organisms HHAT HGNC:18270 hedgehog acyltransferase Q5VTY9 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 80 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms HHATL HGNC:13242 hedgehog acyltransferase-like Q9HCP6 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11374908,11374908,11374908,11374908 endoplasmic reticulum membrane 89 12 cytoplasm. endoplasmic reticulum. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota HHEX HGNC:4901 hematopoietically expressed homeobox Q03014 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11889211,10871399,12826010,11889211,12826010 nucleus 36 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota HHIP HGNC:14866 hedgehog interacting protein Q96QV1 Cell membrane; Peripheral membrane protein (By similarity). Secreted (By similarity). Isoform 2: Cytoplasm (Probable). Plasma membrane (GO:0005886) 11435703 secreted 35 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms HHIPL1 HGNC:19710 HHIP-like 1 Q96JK4 Secreted (Potential). Plasma membrane (GO:0005886) secreted 44 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms HHIPL2 HGNC:25842 HHIP-like 2 Q6UWX4 Secreted (Potential). secreted 95 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms HHLA1 HGNC:4904 HERV-H LTR-associating 1 C9JL84 Secreted (Potential). secreted 13 0 secreted secreted Amniota Euteleostomi Euteleostomi HHLA2 HGNC:4905 HERV-H LTR-associating 2 Q9UM44 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 10444326 secreted 17 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Deuterostomia HHLA3 HGNC:4906 HERV-H LTR-associating 3 Q9XRX5 secreted 65 0 secreted secreted Homininae Homininae Homo HIAT1 HGNC:23363 hippocampus abundant transcript 1 Q96MC6 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 11 12 vacuole membrane vacuole membrane Bilateria Cell.Organisms Cell.Organisms HIATL1 HGNC:23376 hippocampus abundant transcript-like 1 Q5SR56 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 16 12 vacuole membrane vacuole membrane Bilateria Cell.Organisms Cell.Organisms HIATL2 HGNC:23672 hippocampus abundant transcript-like 2 Q5VZR4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 32 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Eutheria Cell.Organisms HIBADH HGNC:4907 3-hydroxyisobutyrate dehydrogenase P31937 Mitochondrion. Mitochondrion (GO:0005739) 2647728,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms HIBCH HGNC:4908 3-hydroxyisobutyryl-CoA hydrolase Q6NVY1 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 16582907,15598749 mitochondrion 77 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms HIC1 HGNC:4909 hypermethylated in cancer 1 Q14526 Nucleus. Nucleus (GO:0005634) 11554746,16269335,16724116 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HIC2 HGNC:18595 hypermethylated in cancer 2 Q96JB3 Nucleus. Nucleus (GO:0005634) 11554746 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HID1 HGNC:15736 HID1 domain containing Q8IV36 Cytoplasm. Golgi apparatus membrane; Lipid- anchor. Note=Shuttles between the cytosol and the Golgi apparatus. Plasma membrane (GO:0005886) 11281419 endoplasmic reticulum membrane 25 4 cytoplasm. plasma membrane multiple Opisthokonta Eukaryota Eukaryota HIF1A HGNC:4910 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Q16665 Cytoplasm. Nucleus. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 7836384,12209691,17024177,16777103,16511565,16543236,16424018,11382768,12209691,16777103 nucleus 19 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms HIF1AN HGNC:17113 hypoxia inducible factor 1, alpha subunit inhibitor Q9NWT6 Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14734545,14734545 nucleus 14 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms HIF3A HGNC:15825 hypoxia inducible factor 3, alpha subunit Q9Y2N7 Nucleus. Cytoplasm. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes (By similarity). Nucleus (GO:0005634) nucleus 20 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Cell.Organisms HIGD1A HGNC:29527 HIG1 hypoxia inducible domain family, member 1A Q9Y241 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane (Probable). mitochondrion membrane 92 2 mitochondrion membrane mitochondrion membrane Euteleostomi Bilateria Opisthokonta HIGD1B HGNC:24318 HIG1 hypoxia inducible domain family, member 1B Q9P298 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 92 2 mitochondrion membrane mitochondrion membrane Theria Tetrapoda Opisthokonta HIGD1C HGNC:28044 HIG1 hypoxia inducible domain family, member 1C A8MV81 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 92 2 mitochondrion membrane mitochondrion membrane Homininae Tetrapoda Opisthokonta HIGD2A HGNC:28311 HIG1 hypoxia inducible domain family, member 2A Q9BW72 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane (Probable). Integral to membrane (GO:0016021) mitochondrion membrane 27 2 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Eukaryota HILPDA HGNC:28859 hypoxia inducible lipid droplet-associated Q9Y5L2 Lipid droplet. Secreted. Membrane; Single- pass membrane protein (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) ,10690527 secreted 70 1 lipid droplet. secreted multiple Catarrhini Eutheria Eutheria HINFP HGNC:17850 histone H4 transcription factor Q9BQA5 Nucleus. Note=Associated with discrete nuclear foci. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11553631,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota HINT1 HGNC:4912 histidine triad nucleotide binding protein 1 P49773 Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8812426,9770345,9770345 mitochondrion 50 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HINT2 HGNC:18344 histidine triad nucleotide binding protein 2 Q9BX68 Mitochondrion. Mitochondrion (GO:0005739) 15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms HINT3 HGNC:18468 histidine triad nucleotide binding protein 3 Q9NQE9 Cytoplasm. Nucleus. Note=Localized as aggregates in the cytoplasm and the nucleus. nucleus 11 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms HIP1 HGNC:4913 huntingtin interacting protein 1 O00291 Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR. Integral to membrane (GO:0016021); Golgi apparatus (GO:0005794) 11532990,9147654,11788820 cytoplasm 16 0 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota NA HIP1R HGNC:18415 huntingtin interacting protein 1 related O75146 Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region. Cytoplasmic vesicle (GO:0016023); Clathrin-coated vesicle (GO:0030136) 11063258,11889126,17318189 nucleus 12 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota HIPK1 HGNC:19006 homeodomain interacting protein kinase 1 Q86Z02 Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. Nucleus (GO:0005634) 12529400 nucleus 43 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms HIPK2 HGNC:14402 homeodomain interacting protein kinase 2 Q9H2X6 Nucleus, PML body. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic. Nucleus (GO:0005634) 11267674,11780126,12907596,12220523,16343438,15896780 nucleus 47 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms HIPK3 HGNC:4915 homeodomain interacting protein kinase 3 Q9H422 Cytoplasm. Nucleus. Nucleus (GO:0005634) 9748262,10640824 nucleus 88 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms HIPK4 HGNC:19007 homeodomain interacting protein kinase 4 Q8NE63 Cytoplasm (By similarity). Nucleus (GO:0005634) cytoplasm 84 0 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms HIRA HGNC:4916 histone cell cycle regulator P54198 Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence. Nucleus (GO:0005634) 9710638 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota NA HIRIP3 HGNC:4917 HIRA interacting protein 3 Q9BW71 Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9710638,17081983,17081983/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa HIST1H1A HGNC:4715 histone cluster 1, H1a Q02539 Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Metazoa HIST1H1B HGNC:4719 histone cluster 1, H1b P16401 Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) ,15635413,15598749 nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Metazoa HIST1H1C HGNC:4716 histone cluster 1, H1c P16403 Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 10997781,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Homininae Homininae Metazoa HIST1H1D HGNC:4717 histone cluster 1, H1d P16402 Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11478838,15635413 nucleus 100 0 nucleus nucleus Theria Euteleostomi Metazoa HIST1H1E HGNC:4718 histone cluster 1, H1e P10412 Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 7607502,15635413 nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Metazoa HIST1H1T HGNC:4720 histone cluster 1, H1t P22492 Nucleus. Chromosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9809674,9809674 nucleus 100 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Metazoa HIST1H2AA HGNC:18729 histone cluster 1, H2aa Q96QV6 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AB HGNC:4734 histone cluster 1, H2ab P04908 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AC HGNC:4733 histone cluster 1, H2ac Q93077 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AD HGNC:4729 histone cluster 1, H2ad P20671 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AE HGNC:4724 histone cluster 1, H2ae P04908 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AG HGNC:4737 histone cluster 1, H2ag P0C0S8 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AH HGNC:13671 histone cluster 1, H2ah Q96KK5 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AI HGNC:4725 histone cluster 1, H2ai P0C0S8 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AJ HGNC:4727 histone cluster 1, H2aj Q99878 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298 nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Eukaryota HIST1H2AK HGNC:4726 histone cluster 1, H2ak P0C0S8 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AL HGNC:4730 histone cluster 1, H2al P0C0S8 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2AM HGNC:4735 histone cluster 1, H2am P0C0S8 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus NA NA Eukaryota HIST1H2BA HGNC:18730 histone cluster 1, H2ba Q96A08 Nucleus. Chromosome. Nucleus (GO:0005634) 12213818 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota HIST1H2BB HGNC:4751 histone cluster 1, H2bb P33778 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BC HGNC:4757 histone cluster 1, H2bc P62807 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Human Eukaryota HIST1H2BD HGNC:4747 histone cluster 1, H2bd P58876 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BE HGNC:4753 histone cluster 1, H2be P62807 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Human Eukaryota HIST1H2BF HGNC:4752 histone cluster 1, H2bf P62807 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Human Eukaryota HIST1H2BG HGNC:4746 histone cluster 1, H2bg P62807 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298 nucleus 100 0 nucleus nucleus Human Human Eukaryota HIST1H2BH HGNC:4755 histone cluster 1, H2bh Q93079 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BI HGNC:4756 histone cluster 1, H2bi P62807 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Human Eukaryota HIST1H2BJ HGNC:4761 histone cluster 1, H2bj P06899 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BK HGNC:13954 histone cluster 1, H2bk O60814 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BL HGNC:4748 histone cluster 1, H2bl Q99880 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BM HGNC:4750 histone cluster 1, H2bm Q99879 Nucleus. Chromosome. Nucleus (GO:0005634) 9439656 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H2BN HGNC:4749 histone cluster 1, H2bn Q99877 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus NA NA Eukaryota HIST1H2BO HGNC:4758 histone cluster 1, H2bo P23527 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3A HGNC:4766 histone cluster 1, H3a P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3B HGNC:4776 histone cluster 1, H3b P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3C HGNC:4768 histone cluster 1, H3c P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3D HGNC:4767 histone cluster 1, H3d P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3E HGNC:4769 histone cluster 1, H3e P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3F HGNC:4773 histone cluster 1, H3f P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus NA NA Eukaryota HIST1H3G HGNC:4772 histone cluster 1, H3g P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus NA NA Eukaryota HIST1H3H HGNC:4775 histone cluster 1, H3h P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3I HGNC:4771 histone cluster 1, H3i P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H3J HGNC:4774 histone cluster 1, H3j P68431 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4A HGNC:4781 histone cluster 1, H4a P62805 Nucleus. Chromosome. Nucleus (GO:0005634) 3035717 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4B HGNC:4789 histone cluster 1, H4b P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4C HGNC:4787 histone cluster 1, H4c P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4D HGNC:4782 histone cluster 1, H4d P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4E HGNC:4790 histone cluster 1, H4e P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4F HGNC:4783 histone cluster 1, H4f P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4G HGNC:4792 histone cluster 1, H4g Q99525 Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634) 9119399 nucleus 81 0 nucleus nucleus Homininae Homininae Eukaryota HIST1H4H HGNC:4788 histone cluster 1, H4h P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4I HGNC:4793 histone cluster 1, H4i P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4J HGNC:4785 histone cluster 1, H4j P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4K HGNC:4784 histone cluster 1, H4k P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST1H4L HGNC:4791 histone cluster 1, H4l P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST2H2AA3 HGNC:4736 histone cluster 2, H2aa3 Q6FI13 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST2H2AA4 HGNC:29668 histone cluster 2, H2aa4 Q6FI13 Nucleus. Chromosome. Chromosome (GO:0005694) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H2AB HGNC:20508 histone cluster 2, H2ab Q8IUE6 Nucleus. Chromosome. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H2AC HGNC:4738 histone cluster 2, H2ac Q16777 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H2BE HGNC:4760 histone cluster 2, H2be Q16778 Nucleus. Chromosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11241673,11241673,15635413 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA HIST2H2BF HGNC:24700 histone cluster 2, H2bf Q5QNW6 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H3A HGNC:20505 histone cluster 2, H3a Q71DI3 Nucleus. Chromosome. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H3C HGNC:20503 histone cluster 2, H3c Q71DI3 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H3D HGNC:25311 histone cluster 2, H3d Q71DI3 Nucleus. Chromosome. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA HIST2H4A HGNC:4794 histone cluster 2, H4a P62805 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST2H4B HGNC:29607 histone cluster 2, H4b P62805 Nucleus. Chromosome. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST3H2A HGNC:20507 histone cluster 3, H2a Q7L7L0 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST3H2BB HGNC:20514 histone cluster 3, H2bb Q8N257 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIST3H3 HGNC:4778 histone cluster 3, H3 Q16695 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Human Euarchontoglires Eukaryota HIST4H4 HGNC:20510 histone cluster 4, H4 P62805 Nucleus. Chromosome. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota HIVEP1 HGNC:4920 human immunodeficiency virus type I enhancer binding protein 1 P15822 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus. Isoform 3: Cytoplasm. Nucleus. Nucleus (GO:0005634) 8289330,1694016 nucleus 65 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota HIVEP2 HGNC:4921 human immunodeficiency virus type I enhancer binding protein 2 P31629 Nucleus. Nucleus (GO:0005634) 2022670,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta HIVEP3 HGNC:13561 human immunodeficiency virus type I enhancer binding protein 3 Q5T1R4 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11804591,11804591 nucleus 29 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta HJURP HGNC:25444 Holliday junction recognition protein Q8NCD3 Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage. nucleus 100 0 nucleus nucleus Eutheria Eutheria Amniota HK1 HGNC:4922 hexokinase 1 P19367 Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding. Cytoplasm (GO:0005737); Mitochondrial membrane (GO:0005740); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 9028305,10978502,9450953,8720117,15598749 mitochondrion membrane 26 0 cytoplasm. mitochondrion. mitochondrion membrane multiple Eukaryota Cell.Organisms Cell.Organisms HK2 HGNC:4923 hexokinase 2 P52789 Mitochondrion outer membrane (By similarity). Note=Its hydrophobic N-terminal sequence may be involved in membrane binding (By similarity). Mitochondrion (GO:0005739) 7622509 mitochondrion membrane 25 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms HK3 HGNC:4925 hexokinase 3 (white cell) P52790 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 4058069,12543931,12488461 mitochondrion membrane 24 0 cytoplasm. secreted multiple Eukaryota Cell.Organisms Cell.Organisms HKDC1 HGNC:23302 hexokinase domain containing 1 Q2TB90 mitochondrion membrane 24 0 mitochondrion membrane mitochondrion membrane Eukaryota Cell.Organisms Cell.Organisms HKR1 HGNC:4928 HKR1, GLI-Kruppel zinc finger family member P10072 Nucleus (Potential). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Catarrhini Eutheria Eukaryota HLA-A HGNC:4931 major histocompatibility complex, class I, A P01891 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Nucleus (GO:0005634) 12857887,10929804,6241835,7005335,2320591,1055432,12574356,1613456,1613456,12594841,17081983 secreted 22 1 endoplasmic reticulum. golgi apparatus. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi NA HLA-B HGNC:4932 major histocompatibility complex, class I, B P01889 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10929804,1055432,12574356,14718574,17081983 secreted 26 1 cytoplasm. plasma membrane. secreted multiple Euteleostomi Euteleostomi NA HLA-C HGNC:4933 major histocompatibility complex, class I, C P04222 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1055432,12574356 secreted 23 1 plasma membrane plasma membrane NA NA NA HLA-DMA HGNC:4934 major histocompatibility complex, class II, DM alpha P28067 Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes. Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Plasma membrane (GO:0005886) 8947036,9768757,10322421,9551909,9551909,8890155,10322421,11441095,9879837,9371817,10716924 secreted 24 1 endoplasmic reticulum. endosome. endosome membrane. golgi apparatus. lysosome. lysosome membrane. plasma membrane multiple Eutheria Tetrapoda NA HLA-DMB HGNC:4935 major histocompatibility complex, class II, DM beta P28068 Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes. Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Plasma membrane (GO:0005886) 8947036,9768757,10322421,9551909,9551909,8890155,10322421,11441095,9879837,9371817,10716924 secreted 22 1 endoplasmic reticulum. endosome. endosome membrane. golgi apparatus. lysosome. lysosome membrane. plasma membrane multiple NA NA NA HLA-DOA HGNC:4936 major histocompatibility complex, class II, DO alpha P06340 Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 8890155,8890155, secreted 18 1 endoplasmic reticulum. endosome membrane. lysosome. lysosome membrane multiple Eutheria Euteleostomi NA HLA-DOB HGNC:4937 major histocompatibility complex, class II, DO beta P13765 Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER. Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 8890155,9088974,9088974 secreted 17 1 endoplasmic reticulum. endosome membrane. golgi apparatus. lysosome. lysosome membrane multiple NA NA NA HLA-DPA1 HGNC:4938 major histocompatibility complex, class II, DP alpha 1 P20036 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 8649448 secreted 20 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Amniota Euteleostomi NA HLA-DPB1 HGNC:4940 major histocompatibility complex, class II, DP beta 1 P04440 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 3015787 secreted 17 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Euteleostomi Euteleostomi NA HLA-DQA1 HGNC:4942 major histocompatibility complex, class II, DQ alpha 1 P01909 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 14734754 secreted 15 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Human Theria NA HLA-DQA2 HGNC:4943 major histocompatibility complex, class II, DQ alpha 2 P01906 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 9036956 secreted 18 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Human Theria NA HLA-DQB1 HGNC:4944 major histocompatibility complex, class II, DQ beta 1 P01920 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 6316358 secreted 14 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Euteleostomi Euteleostomi NA HLA-DQB2 HGNC:4945 major histocompatibility complex, class II, DQ beta 2 P05538 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 3858830 secreted 24 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Euteleostomi Euteleostomi NA HLA-DRA HGNC:4947 major histocompatibility complex, class II, DR alpha P01903 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 8316295,11777970,8649448,10480952,6955026,1512535,6955026 secreted 19 1 endoplasmic reticulum. endoplasmic reticulum membrane. endosome membrane. golgi apparatus. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Amniota Euteleostomi NA HLA-DRB1 HGNC:4948 major histocompatibility complex, class II, DR beta 1 P01911 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886); Endosome (GO:0005768); Lysosome (GO:0005764) 10716924,1602009,11070170,10716924,10716924,8612229 plasma membrane 23 1 endoplasmic reticulum membrane. endosome. endosome membrane. golgi apparatus membrane. lysosome. lysosome membrane. plasma membrane multiple Euteleostomi Euteleostomi NA HLA-DRB5 HGNC:4953 major histocompatibility complex, class II, DR beta 5 Q30154 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Plasma membrane (GO:0005886) 3456344 secreted 29 1 endoplasmic reticulum membrane. endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Human Human Craniata HLA-E HGNC:4962 major histocompatibility complex, class I, E P13747 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9486650,9427624,10064069 secreted 19 1 plasma membrane plasma membrane Homininae Homininae NA HLA-F HGNC:4963 major histocompatibility complex, class I, F P30511 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10605026 secreted 22 1 plasma membrane plasma membrane Catarrhini Euarchontoglires NA HLA-G HGNC:4964 major histocompatibility complex, class I, G P17693 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 12582157,9144223,12440768,10479058,10360962,12874224,12582157,12582157,11807769,7584149,10082427,10360962,10479058 secreted 23 1 endoplasmic reticulum. golgi apparatus. plasma membrane. secreted multiple Homininae Homininae NA HLCS HGNC:4976 holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) P50747 Cytoplasm. Mitochondrion. Cytoplasm (GO:0005737) 9630604 cytoplasm 19 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms HLF HGNC:4977 hepatic leukemia factor Q16534 Nucleus (Probable). Nucleus (GO:0005634) 9742120 nucleus 44 0 nucleus nucleus Deuterostomia Bilateria Eumetazoa HLTF HGNC:11099 helicase-like transcription factor Q14527 Cytoplasm (By similarity). Nucleus. Nucleus, nucleolus (By similarity). Nucleus, nucleoplasm (By similarity). Note=Nuclear localization is stimulated by progesterone (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 8672239,9126292,15635413,17081983 mitochondrion membrane 21 0 cytoplasm. nucleus multiple Mammalia Eukaryota Cell.Organisms HLX HGNC:4978 H2.0-like homeobox Q14774 Nucleus (Potential). Nucleus (GO:0005634) 1375114,1349016,17081983 nucleus 33 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HM13 HGNC:16435 histocompatibility (minor) 13 Q8TCT9 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Isoform 4: Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 31 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota HMBOX1 HGNC:26137 homeobox containing 1 Q6NT76 Nucleus. Cytoplasm. Note=Predominantly detected in cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16825764,16825764 nucleus 21 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eumetazoa HMBS HGNC:4982 hydroxymethylbilane synthase P08397 Cytoplasm (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 3816774,12917623,12917623 mitochondrion 31 0 cytoplasm. nucleus multiple NA NA NA HMCES HGNC:24446 5-hydroxymethylcytosine (hmC) binding, ES cell-specific Q96FZ2 nucleus 38 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms HMCN1 HGNC:19194 hemicentin 1 Q96RW7 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Extracellular (GO:0005576) 14570714 secreted 24 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms HMCN2 HGNC:21293 hemicentin 2 Q8NDA2 Secreted, extracellular space, extracellular matrix (By similarity). secreted 76 0 secreted secreted NA NA NA HMG20A HGNC:5001 high mobility group 20A Q9NP66 Nucleus (By similarity). Nucleus (GO:0005634) 10773667 nucleus 40 0 nucleus nucleus Bilateria Bilateria Eukaryota HMG20B HGNC:5002 high mobility group 20B Q9P0W2 Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2. Nucleus (GO:0005634) 11207365 nucleus 100 0 nucleus nucleus Human Euteleostomi Eukaryota HMGA1 HGNC:5010 high mobility group AT-hook 1 P17096 Nucleus. Chromosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 13680222,17081983,13680222 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Eutheria HMGA2 HGNC:5009 high mobility group AT-hook 2 P52926 Nucleus. Nucleus (GO:0005634) 1762909,13679031,18832382 nucleus 100 0 nucleus nucleus Euarchontoglires Deuterostomia Opisthokonta HMGB1 HGNC:4983 high mobility group box 1 P09429 Nucleus. Chromosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 12231511,12231511,12231511,10652254,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota HMGB2 HGNC:5000 high mobility group box 2 P26583 Nucleus. Chromosome. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12925773,1551873,12925773,12925773,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Theria Euteleostomi Eukaryota HMGB3 HGNC:5004 high mobility group box 3 O15347 Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634) 9598312 nucleus 96 0 nucleus nucleus Euteleostomi Eukaryota NA HMGB4 HGNC:24954 high mobility group box 4 Q8WW32 Nucleus (By similarity). Chromosome (By similarity). nucleus 32 0 nucleus nucleus Theria Theria Eukaryota HMGCL HGNC:5005 3-hydroxymethyl-3-methylglutaryl-CoA lyase P35914 Mitochondrion matrix. Peroxisome. Note=Unprocessed form is peroxisomal. Mitochondrion (GO:0005739); Peroxisome (GO:0005777); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 8027038,7527399,7527399,14718574 mitochondrion 55 0 endoplasmic reticulum. mitochondrion. peroxisome. secreted multiple Bilateria Cell.Organisms Cell.Organisms HMGCLL1 HGNC:21359 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 Q8TB92 Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. mitochondrion 47 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms HMGCR HGNC:5006 3-hydroxy-3-methylglutaryl-CoA reductase P04035 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Peroxisome (GO:0005777); Extracellular (GO:0005576); Microsome (GO:0005792) 2991281,10449533,1755834,12803139,3308873 endoplasmic reticulum membrane 100 8 endoplasmic reticulum. endoplasmic reticulum membrane. peroxisome. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms HMGCS1 HGNC:5007 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Q01581 Cytoplasm. Cytoplasm (GO:0005737) 7913309,1971108 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms HMGCS2 HGNC:5008 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) P54868 Mitochondrion. Mitochondrion (GO:0005739) 7851882 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms HMGN1 HGNC:4984 high mobility group nucleosome binding domain 1 P05114 Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12215538,12215538,15635413 nucleus 95 0 cytoplasm. nucleus multiple Amniota Amniota Amniota HMGN2 HGNC:4986 high mobility group nucleosomal binding domain 2 P05204 Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9852141,9852141 nucleus 94 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Bilateria HMGN3 HGNC:12312 high mobility group nucleosomal binding domain 3 Q15651 Nucleus. Nucleus (GO:0005634) 11356838,17081983 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi HMGN4 HGNC:4989 high mobility group nucleosomal binding domain 4 O00479 Nucleus (By similarity). Nucleus (GO:0005634) 11410162 nucleus 79 0 nucleus nucleus Catarrhini Mammalia Bilateria HMGN5 HGNC:8013 high mobility group nucleosome binding domain 5 P82970 Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin (By similarity). Nucleus (GO:0005634) 11161810 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Amniota HMGXB3 HGNC:28982 HMG box domain containing 3 Q12766 Nucleus (Potential). nucleus 91 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa HMGXB4 HGNC:5003 HMG box domain containing 4 Q9UGU5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 27 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota HMHA1 HGNC:17102 histocompatibility (minor) HA-1 Q92619 Plasma membrane (GO:0005886) 8843592 nucleus 22 0 nucleus nucleus Euteleostomi Bilateria Eukaryota HMHB1 HGNC:29677 histocompatibility (minor) HB-1 O97980 secreted 22 0 secreted secreted Catarrhini Catarrhini Homo HMMR HGNC:5012 hyaluronan-mediated motility receptor (RHAMM) O75330 Cell surface. Cytoplasm (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Centrosome (GO:0005813) 11448954,11448954,11448954,11433424,12808028,15561729 cytoplasm 5 0 cytoplasm. mitochondrion. nucleus multiple Chordata Chordata Metazoa HMOX1 HGNC:5013 heme oxygenase (decycling) 1 P09601 Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Cytosol (GO:0005829);Microsome (GO:0005792); Cytosol (GO:0005829) 10082382,,18544348,,,18544348,/,18544348,,,18544348, mitochondrion 33 1 cytoplasm. endoplasmic reticulum multiple Euteleostomi Eukaryota Cell.Organisms HMOX2 HGNC:5014 heme oxygenase (decycling) 2 P30519 Microsome. Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 11572959,15598749 mitochondrion 35 1 endoplasmic reticulum. mitochondrion multiple Chordata Cell.Organisms Cell.Organisms HMSD HGNC:23037 histocompatibility (minor) serpin domain containing A8MTL9 Secreted (Potential). cytoplasm 49 0 cytoplasm cytoplasm NA NA Cell.Organisms HMX1 HGNC:5017 H6 family homeobox 1 Q9NP08 Nucleus (Probable). Nucleus (GO:0005634) 10206974 nucleus 35 1 nucleus nucleus Tetrapoda Tetrapoda Metazoa HMX2 HGNC:5018 H6 family homeobox 2 A2RU54 Nucleus (By similarity). Nucleus (GO:0005634) 7647458 nucleus 34 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HMX3 HGNC:5019 H6 family homeobox 3 A6NHT5 Nucleus (By similarity). nucleus 35 0 nucleus nucleus Euteleostomi Bilateria Eukaryota HN1 HGNC:14569 hematological and neurological expressed 1 Q9UK76 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15094197,17081983,17081983/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Bilateria HN1L HGNC:14137 hematological and neurological expressed 1-like Q9H910 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15334068,15094197,17081983,15094197 nucleus 19 0 cytoplasm. nucleus multiple Chordata Chordata Bilateria HNF1A HGNC:11621 HNF1 homeobox A P20823 Nucleus. Nucleus (GO:0005634) 11266540 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa HNF1B HGNC:11630 HNF1 homeobox B P35680 Nucleus. Nucleus (GO:0005634) 1677179,14633622 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa HNF4A HGNC:5024 hepatocyte nuclear factor 4, alpha P41235 Nucleus. Nucleus (GO:0005634) 7651430 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa HNF4G HGNC:5026 hepatocyte nuclear factor 4, gamma Q14541 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 72 0 nucleus nucleus Bilateria Bilateria Metazoa HNMT HGNC:5028 histamine N-methyltransferase P50135 Cytoplasm. Cytosol (GO:0005829) 12358773 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eumetazoa HNRNPA0 HGNC:5030 heterogeneous nuclear ribonucleoprotein A0 Q13151 Nucleus (By similarity). Note=Component of ribonucleosomes (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 7585247,19059367,15635413,17215244,15598749 nucleus 45 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms HNRNPA1 HGNC:5031 heterogeneous nuclear ribonucleoprotein A1 P09651 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 8521471,19059367,8521471,17081983,11790298,15635413,15598749 nucleus 68 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Bilateria Cell.Organisms HNRNPA1L2 HGNC:27067 heterogeneous nuclear ribonucleoprotein A1-like 2 Q32P51 Nucleus (By similarity). Cytoplasm (By similarity). nucleus 67 0 nucleus nucleus Human Human Cell.Organisms HNRNPA2B1 HGNC:5033 heterogeneous nuclear ribonucleoprotein A2/B1 P22626 Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 14692562,9761751,12243756,19059367,11790298,9761751,12243756,15598749/12243756,10978504,12243756/10978504 nucleus 70 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Bilateria Cell.Organisms HNRNPA3 HGNC:24941 heterogeneous nuclear ribonucleoprotein A3 P51991 Nucleus (By similarity). Note=Component of ribonucleosomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11886857,11886857 nucleus 59 0 cytoplasm. nucleus multiple Theria Deuterostomia Cell.Organisms HNRNPAB HGNC:5034 heterogeneous nuclear ribonucleoprotein A/B Q99729 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleolus (GO:0005730); Nucleus (GO:0005634) 11790298,15635413,14704337,19059367 nucleus 30 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms HNRNPC HGNC:5035 heterogeneous nuclear ribonucleoprotein C (C1/C2) P07910 Nucleus. Note=Component of ribonucleosomes. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 17081983/9516488,15034300,19059367,10629032,15494373,15034300,17081983,11790298,15635413,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Bilateria Cell.Organisms HNRNPCL1 HGNC:29295 heterogeneous nuclear ribonucleoprotein C-like 1 O60812 Nucleus (By similarity). Note=Component of ribonucleosomes (By similarity). nucleus 88 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms HNRNPD HGNC:5036 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) Q14103 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739);Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9615222,16902409,19059367,10900464,16902409,15598749/12674497/8246982,17081983,8246982,17081983/12674497,17081983,17081983 cytoplasm 30 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Bilateria Cell.Organisms HNRNPDL HGNC:5037 heterogeneous nuclear ribonucleoprotein D-like O14979 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11705999,10072754,19059367,15598749 cytoplasm 31 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Eukaryota Cell.Organisms HNRNPF HGNC:5039 heterogeneous nuclear ribonucleoprotein F P52597 Nucleus, nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10456323,14980514,7499401,17081983,7499401,10456323,14980514,15635413 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota HNRNPH1 HGNC:5041 heterogeneous nuclear ribonucleoprotein H1 (H) P31943 Nucleus, nucleoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10456323,19059367,11790298,15635413,14980514 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota HNRNPH2 HGNC:5042 heterogeneous nuclear ribonucleoprotein H2 (H') P55795 Nucleus, nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10456323,14980514,14980514 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota NA HNRNPH3 HGNC:5043 heterogeneous nuclear ribonucleoprotein H3 (2H9) P31942 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 17081983/8999868,11790298,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Tetrapoda Tetrapoda Eukaryota HNRNPK HGNC:5044 heterogeneous nuclear ribonucleoprotein K P61978 Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 11790298,15635413,15170860,12951515,11231586,15860232,17081983,15170860,11741984,15598749,15860232,9553145,8107114,9651361,17081983 cytoplasm 17 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Opisthokonta HNRNPL HGNC:5045 heterogeneous nuclear ribonucleoprotein L P14866 Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15635413,2687284,19059367,9880507,15598749 nucleus 15 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Eukaryota HNRNPLL HGNC:25127 heterogeneous nuclear ribonucleoprotein L-like Q8WVV9 Nucleolus (GO:0005730) 15635413 nucleus 19 0 nucleus nucleus Bilateria Eukaryota Eukaryota HNRNPM HGNC:5046 heterogeneous nuclear ribonucleoprotein M P52272 Nucleus, nucleolus. Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Nucleus (GO:0005634);Nucleus (GO:0005634) 8088785,11790298,15635413,15598749,15561729/8692693 nucleus 100 0 mitochondrion. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms HNRNPR HGNC:5047 heterogeneous nuclear ribonucleoprotein R O43390 Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9421497,15652821,15561729,15635413,15598749 nucleus 39 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms HNRNPU HGNC:5048 heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) Q00839 Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 17081983,17081983/11813259,7509195,15652821,19059367,15598749,17081983 nucleus 42 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms HNRNPUL1 HGNC:17011 heterogeneous nuclear ribonucleoprotein U-like 1 Q9BUJ2 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9733834,12489984,11513728,9733834,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota HNRNPUL2 HGNC:25451 heterogeneous nuclear ribonucleoprotein U-like 2 Q1KMD3 Nucleus (By similarity). Nucleus (GO:0005634) 8068679 nucleus 94 0 nucleus nucleus Theria Eukaryota Eukaryota HOGA1 HGNC:25155 4-hydroxy-2-oxoglutarate aldolase 1 Q86XE5 Mitochondrion (By similarity). mitochondrion 88 0 mitochondrion mitochondrion NA NA Cell.Organisms HOMER1 HGNC:17512 homer homolog 1 (Drosophila) Q86YM7 Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 9808458,15033484,9808458,15033484,9808458,10464340 nucleus 28 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Euteleostomi Eukaryota HOMER2 HGNC:17513 homer homolog 2 (Drosophila) Q9NSB8 Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 10653696,9808458,9808458,9808458,9808458 cytoplasm 16 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Deuterostomia Bilateria Eukaryota HOMER3 HGNC:17514 homer homolog 3 (Drosophila) Q9NSC5 Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity). Plasma membrane (GO:0005886); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Nucleus (GO:0005634) 16979624,16979624,9069287,9808458,16979624,9808458,9808458,9808458 cytoplasm 18 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota HOMEZ HGNC:20164 homeobox and leucine zipper encoding Q8IX15 Nucleus. Nucleus (GO:0005634) 12925734 nucleus 100 0 nucleus nucleus Mammalia Mammalia Chordata HOOK1 HGNC:19884 hook microtubule-tethering protein 1 Q9UJC3 Cytoplasm, cytoskeleton (By similarity). Cytoplasm. Note=Localizes to the spermatid manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. Cytoplasm (GO:0005737) 11238449,12075009 cytoplasm 91 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota HOOK2 HGNC:19885 hook microtubule-tethering protein 2 Q96ED9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. Cytoplasm (GO:0005737) 11238449 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota HOOK3 HGNC:23576 hook microtubule-tethering protein 3 Q86VS8 Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex (By similarity). Localizes to microtubule asters in prophase (By similarity). Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 11238449,11238449,15075236,11238449,15075236,15075236 cytoplasm 48 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Deuterostomia Eukaryota Eukaryota HOPX HGNC:24961 HOP homeobox Q9BPY8 Nucleus (By similarity). Nucleus (GO:0005634) 12297045 nucleus 30 0 nucleus nucleus Tetrapoda Tetrapoda Bilateria HORMAD1 HGNC:25245 HORMA domain containing 1 Q86X24 Nucleus (By similarity). Chromosome (By similarity). Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). nucleus 48 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota HORMAD2 HGNC:28383 HORMA domain containing 2 Q8N7B1 Nucleus. Chromosome (By similarity). Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). nucleus 100 0 nucleus nucleus Human Human Eukaryota HOXA1 HGNC:5099 homeobox A1 P49639 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HOXA10 HGNC:5100 homeobox A10 P31260 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12145285,10766757,15213244,15213244 nucleus 100 0 cytoplasm. nucleus multiple NA NA Eukaryota HOXA11 HGNC:5101 homeobox A11 P31270 Nucleus. Nucleus (GO:0005634) 11396649 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota HOXA13 HGNC:5102 homeobox A13 P31271 Nucleus. Nucleus (GO:0005634) 10835276 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta HOXA2 HGNC:5103 homeobox A2 O43364 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota HOXA3 HGNC:5104 homeobox A3 O43365 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota HOXA4 HGNC:5105 homeobox A4 Q00056 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Chordata Eukaryota HOXA5 HGNC:5106 homeobox A5 P20719 Nucleus. Nucleus (GO:0005634) 10875927 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HOXA6 HGNC:5107 homeobox A6 P31267 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Amniota Eukaryota HOXA7 HGNC:5108 homeobox A7 P31268 Nucleus. Nucleus (GO:0005634) 11435435 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota HOXA9 HGNC:5109 homeobox A9 P31269 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10082572,15161102,10082572 nucleus 100 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota HOXB1 HGNC:5111 homeobox B1 P14653 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Chordata Chordata Metazoa HOXB13 HGNC:5112 homeobox B13 Q92826 Nucleus. Nucleus (GO:0005634) 7738 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota HOXB2 HGNC:5113 homeobox B2 P14652 Nucleus. Nucleus (GO:0005634) 7913891,10595394 nucleus 100 0 nucleus nucleus Human Chordata Opisthokonta HOXB3 HGNC:5114 homeobox B3 P14651 Nucleus. Nucleus (GO:0005634) 8920965 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HOXB4 HGNC:5115 homeobox B4 P17483 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11085749,11984874,12761847 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota HOXB5 HGNC:5116 homeobox B5 P09067 Nucleus. Nucleus (GO:0005634) 8101633 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota HOXB6 HGNC:5117 homeobox B6 P17509 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10906782,10906782 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa HOXB7 HGNC:5118 homeobox B7 P09629 Nucleus. Nucleus (GO:0005634) 7738096 nucleus 100 0 nucleus nucleus Mammalia Euteleostomi NA HOXB8 HGNC:5119 homeobox B8 P17481 Nucleus. Nucleus (GO:0005634) 11571641 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota HOXB9 HGNC:5120 homeobox B9 P17482 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Metazoa HOXC10 HGNC:5122 homeobox C10 Q9NYD6 Nucleus. Nucleus (GO:0005634) 10835276 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota HOXC11 HGNC:5123 homeobox C11 O43248 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HOXC12 HGNC:5124 homeobox C12 P31275 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Chordata Chordata Eumetazoa HOXC13 HGNC:5125 homeobox C13 P31276 Nucleus. Nucleus (GO:0005634) 10835276 nucleus 100 0 nucleus nucleus Eutheria Euteleostomi Metazoa HOXC4 HGNC:5126 homeobox C4 P09017 Nucleus. Nucleus (GO:0005634) 7718879,12672812 nucleus 100 0 nucleus nucleus Eutheria Euteleostomi Eukaryota HOXC5 HGNC:5127 homeobox C5 Q00444 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Eutheria Euteleostomi Opisthokonta HOXC6 HGNC:5128 homeobox C6 P09630 Nucleus. Nucleus (GO:0005634) 7738096 nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Eukaryota HOXC8 HGNC:5129 homeobox C8 P31273 Nucleus. Nucleus (GO:0005634) 10722652,10224145 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HOXC9 HGNC:5130 homeobox C9 P31274 Nucleus. Nucleus (GO:0005634) 8570656 nucleus 100 0 nucleus nucleus Euarchontoglires Euteleostomi Metazoa HOXD1 HGNC:5132 homeobox D1 Q9GZZ0 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Mammalia Bilateria Eukaryota HOXD10 HGNC:5133 homeobox D10 P28358 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota HOXD11 HGNC:5134 homeobox D11 P31277 Nucleus. Nucleus (GO:0005634) 10075849 nucleus 100 0 nucleus nucleus Human Euteleostomi Eukaryota HOXD12 HGNC:5135 homeobox D12 P35452 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota HOXD13 HGNC:5136 homeobox D13 P35453 Nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Opisthokonta HOXD3 HGNC:5137 homeobox D3 P31249 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Chordata Chordata Eukaryota HOXD4 HGNC:5138 homeobox D4 P09016 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota HOXD8 HGNC:5139 homeobox D8 P13378 Nucleus. Nucleus (GO:0005634) 7913891 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota HOXD9 HGNC:5140 homeobox D9 P28356 Nucleus. Nucleus (GO:0005634) 7926763 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota HP HGNC:5141 haptoglobin P00738 Secreted. Extracellular (GO:0005576) 11865981 secreted 100 0 secreted secreted NA NA Cell.Organisms HP1BP3 HGNC:24973 heterochromatin protein 1, binding protein 3 Q5SSJ5 Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634) none,15561729 nucleus 26 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria HPCA HGNC:5144 hippocalcin P84074 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11836243,11836243 cytoplasm 15 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Cell.Organisms HPCAL1 HGNC:5145 hippocalcin-like 1 P37235 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12445467,10683417,10683417 mitochondrion membrane 25 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms HPCAL4 HGNC:18212 hippocalcin like 4 Q9UM19 cytoplasm 17 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms HPD HGNC:5147 4-hydroxyphenylpyruvate dioxygenase P32754 cytoplasm 26 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms HPDL HGNC:28242 4-hydroxyphenylpyruvate dioxygenase-like Q96IR7 cytoplasm 13 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms HPGD HGNC:5154 hydroxyprostaglandin dehydrogenase 15-(NAD) P15428 Cytoplasm. Cytoplasm (GO:0005737) 12144871 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Cell.Organisms HPGDS HGNC:17890 hematopoietic prostaglandin D synthase O60760 Cytoplasm. Cytoplasm (GO:0005737) 9353279,12895599 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms HPN HGNC:5155 hepsin P05981 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 1885621,1885621,1885621 secreted 32 1 mitochondrion. nucleus. plasma membrane multiple Theria Bilateria Cell.Organisms HPR HGNC:5156 haptoglobin-related protein P00739 Secreted (Potential). Extracellular (GO:0005576) 10085035,16188874 secreted 87 0 secreted secreted NA NA Cell.Organisms HPRT1 HGNC:5157 hypoxanthine phosphoribosyltransferase 1 P00492 Cytoplasm. Cytoplasm (GO:0005737) 8524221 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms HPS1 HGNC:5163 Hermansky-Pudlak syndrome 1 Q92902 Cytosol (GO:0005829); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 12756248,10625677,12663659,12756248,10625677,12756248 nucleus 39 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota HPS3 HGNC:15597 Hermansky-Pudlak syndrome 3 Q969F9 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11707070 cytoplasm 76 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa HPS4 HGNC:15844 Hermansky-Pudlak syndrome 4 Q9NQG7 Membrane fraction (GO:0005624); Cytosol (GO:0005829) 12847290,12756248,12756248 nucleus 61 0 cytoplasm cytoplasm Theria Euteleostomi Holozoa HPS5 HGNC:17022 Hermansky-Pudlak syndrome 5 Q9UPZ3 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 10094488 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Holozoa HPS6 HGNC:18817 Hermansky-Pudlak syndrome 6 Q86YV9 Microsome membrane. Cytoplasm, cytosol. Early endosome membrane. nucleus 49 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata HPSE HGNC:5164 heparanase Q9Y251 Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Lysosome (GO:0005764); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 12441129,12441129,12746471,12746471,14573609 secreted 52 0 cytoplasm. endoplasmic reticulum. golgi apparatus. lysosome. nucleus. secreted multiple Euteleostomi Cell.Organisms Cell.Organisms HPSE2 HGNC:18374 heparanase 2 Q8WWQ2 Secreted, extracellular space, extracellular matrix. Plasma membrane (GO:0005886) secreted 100 0 secreted secreted Tetrapoda Bilateria Cell.Organisms HPX HGNC:5171 hemopexin P02790 Secreted. Extracellular (GO:0005576) 10443938,8855948,16199891,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa HR HGNC:5172 hair growth associated O43593 Nucleus. Nucleus (GO:0005634) 11641275,12847098 nucleus 100 0 nucleus nucleus Mammalia Mammalia Eukaryota HRAS HGNC:5173 Harvey rat sarcoma viral oncogene homolog P01112 Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GNB2L1 to the perinuclear region. Plasma membrane (GO:0005886); Cytosol (GO:0005829); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Mitochondrion (GO:0005739) 10989457,15705808,11022048,15031297,9020890,15031288,12750467,15705808,15031297,15031288,15031297,15031288,10490827 cytoplasm 25 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Euteleostomi Eukaryota Cell.Organisms HRASLS HGNC:14922 HRAS-like suppressor Q9HDD0 Membrane; Single-pass membrane protein (By similarity). Cytoplasm (GO:0005737) 10542256 mitochondrion 8 1 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms HRASLS2 HGNC:17824 HRAS-like suppressor 2 Q9NWW9 Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization. mitochondrion 12 1 cytoplasm cytoplasm Catarrhini Catarrhini Cell.Organisms HRASLS5 HGNC:24978 HRAS-like suppressor family, member 5 Q96KN8 mitochondrion 22 0 mitochondrion mitochondrion Eutheria Eutheria Cell.Organisms HRC HGNC:5178 histidine rich calcium binding protein P23327 Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum (GO:0016529); Extracellular (GO:0005576) 10462052,12543931,12488461 endoplasmic reticulum 100 0 endoplasmic reticulum. secreted multiple Eutheria Euteleostomi Eumetazoa HRCT1 HGNC:33872 histidine rich carboxyl terminus 1 Q6UXD1 Membrane; Single-pass membrane protein (Potential). secreted 93 1 secreted secreted Catarrhini Euarchontoglires Eutheria HRG HGNC:5181 histidine-rich glycoprotein P04196 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 3958188,16188874,2566603 secreted 100 0 secreted secreted Amniota Amniota Euteleostomi HRH1 HGNC:5182 histamine receptor H1 P35367 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8590995 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa HRH2 HGNC:5183 histamine receptor H2 P25021 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7575521 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa HRH3 HGNC:5184 histamine receptor H3 Q9Y5N1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11956964 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa HRH4 HGNC:17383 histamine receptor H4 Q9H3N8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11118334 plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Eumetazoa HRK HGNC:5185 harakiri, BCL2 interacting protein O00198 Membrane; Single-pass membrane protein. Mitochondrion. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783) 9130713,15031724,9130713 secreted 42 1 endoplasmic reticulum. mitochondrion multiple Theria Theria Mammalia HRNR HGNC:20846 hornerin Q86YZ3 Cytoplasmic granule (By similarity). Note=Found in keratohyalin granules in the granular cells of the epidermis (By similarity). Plasma membrane (GO:0005886) 15507446 cytoplasm 34 0 cytoplasm cytoplasm Homininae Homininae Amniota HRSP12 HGNC:16897 heat-responsive protein 12 P52758 Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 9463573,9767104,8973653,10961346,10961346,8973653 mitochondrion 21 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HS1BP3 HGNC:24979 HCLS1 binding protein 3 Q53T59 nucleus 71 0 nucleus nucleus Tetrapoda Deuterostomia Holozoa HS2ST1 HGNC:5193 heparan sulfate 2-O-sulfotransferase 1 Q7LGA3 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 97 0 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Holozoa HS3ST1 HGNC:5194 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 O14792 Golgi apparatus lumen (Probable). Extracellular (GO:0005576) 9988768 golgi apparatus membrane 14 0 golgi apparatus. secreted multiple Euteleostomi Cell.Organisms Cell.Organisms HS3ST2 HGNC:5195 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 Q9Y278 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9988768,9988768 golgi apparatus membrane 20 1 cytoplasm. golgi apparatus membrane. plasma membrane multiple Theria Euteleostomi Cell.Organisms HS3ST3A1 HGNC:5196 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 Q9Y663 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9988768,9988768 golgi apparatus membrane 18 1 cytoplasm. golgi apparatus membrane. plasma membrane multiple Eutheria Cell.Organisms Cell.Organisms HS3ST3B1 HGNC:5198 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 Q9Y662 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9988768,9988768 golgi apparatus membrane 19 1 cytoplasm. golgi apparatus membrane. plasma membrane multiple Eutheria Cell.Organisms Cell.Organisms HS3ST4 HGNC:5200 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 Q9Y661 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Extracellular (GO:0005576) 12080045 cytoplasm 26 1 golgi apparatus membrane. secreted multiple Homininae Euteleostomi Cell.Organisms HS3ST5 HGNC:19419 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 Q8IZT8 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) golgi apparatus membrane 18 0 golgi apparatus membrane golgi apparatus membrane NA NA Cell.Organisms HS3ST6 HGNC:14178 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 Q96QI5 Golgi apparatus membrane; Single-pass type II membrane protein (Probable). Golgi apparatus (GO:0005794) golgi apparatus membrane 20 1 golgi apparatus membrane golgi apparatus membrane Human Eukaryota Cell.Organisms HS6ST1 HGNC:5201 heparan sulfate 6-O-sulfotransferase 1 O60243 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 31 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Metazoa HS6ST2 HGNC:19133 heparan sulfate 6-O-sulfotransferase 2 Q96MM7 Membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 16 2 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms HS6ST3 HGNC:19134 heparan sulfate 6-O-sulfotransferase 3 Q8IZP7 Membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) 15226404 secreted 20 1 golgi apparatus golgi apparatus Catarrhini Euteleostomi Metazoa HSBP1 HGNC:5203 heat shock factor binding protein 1 O75506 Nucleus. Nucleus (GO:0005634) 9649501 nucleus 100 0 nucleus nucleus NA NA Eukaryota HSBP1L1 HGNC:37243 heat shock factor binding protein 1-like 1 C9JCN9 nucleus 27 0 nucleus nucleus NA NA Eukaryota HSCB HGNC:28913 HscB mitochondrial iron-sulfur cluster co-chaperone Q8IWL3 Cytoplasm. Mitochondrion. Mitochondrion (GO:0005739) mitochondrion 14 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms HSD11B1 HGNC:5208 hydroxysteroid (11-beta) dehydrogenase 1 P28845 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 12858176 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Deuterostomia Eukaryota Cell.Organisms HSD11B1L HGNC:30419 hydroxysteroid (11-beta) dehydrogenase 1-like Q7Z5J1 Secreted (Potential). endoplasmic reticulum membrane 35 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Cell.Organisms HSD11B2 HGNC:5209 hydroxysteroid (11-beta) dehydrogenase 2 P80365 Microsome. Endoplasmic reticulum. Endosome (GO:0005768) 8611140 mitochondrion 19 1 endoplasmic reticulum. endosome multiple Euteleostomi Opisthokonta Cell.Organisms HSD17B1 HGNC:5210 hydroxysteroid (17-beta) dehydrogenase 1 P14061 Cytoplasm. Cytoplasm (GO:0005737) 7648200 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms HSD17B10 HGNC:4800 hydroxysteroid (17-beta) dehydrogenase 10 Q99714 Mitochondrion. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10329704,11559359,15598749,10371197,9338779,9338779 mitochondrion 100 0 endoplasmic reticulum. mitochondrion multiple Bilateria Cell.Organisms NA HSD17B11 HGNC:22960 hydroxysteroid (17-beta) dehydrogenase 11 Q8NBQ5 Secreted (Potential). Cytoplasm (GO:0005737) 12697717 cytoplasm 13 1 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms HSD17B12 HGNC:18646 hydroxysteroid (17-beta) dehydrogenase 12 Q53GQ0 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 12482854,15598749 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms HSD17B13 HGNC:18685 hydroxysteroid (17-beta) dehydrogenase 13 Q7Z5P4 Secreted (Potential). mitochondrion 11 2 mitochondrion mitochondrion Eutheria Tetrapoda Cell.Organisms HSD17B14 HGNC:23238 hydroxysteroid (17-beta) dehydrogenase 14 Q9BPX1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Homininae Cell.Organisms Cell.Organisms HSD17B2 HGNC:5211 hydroxysteroid (17-beta) dehydrogenase 2 P37059 Membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 8099587,7824086,7824086,17081983 cytoplasm 19 3 endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Opisthokonta Cell.Organisms HSD17B3 HGNC:5212 hydroxysteroid (17-beta) dehydrogenase 3 P37058 Endoplasmic reticulum (GO:0005783) 8075637 endoplasmic reticulum membrane 26 3 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Cell.Organisms HSD17B4 HGNC:5213 hydroxysteroid (17-beta) dehydrogenase 4 P51659 Peroxisome. Peroxisome (GO:0005777); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 8902629,10199776,15635413,15598749 peroxisome 100 0 cytoplasm. mitochondrion. nucleus. peroxisome multiple Bilateria Cell.Organisms Cell.Organisms HSD17B6 HGNC:23316 hydroxysteroid (17-beta) dehydrogenase 6 O14756 Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side (Potential). Endoplasmic reticulum (GO:0005783) 11513953 cytoplasm 38 1 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms HSD17B7 HGNC:5215 hydroxysteroid (17-beta) dehydrogenase 7 P56937 Cell membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12829805 plasma membrane 100 1 endoplasmic reticulum. plasma membrane multiple Deuterostomia Opisthokonta Cell.Organisms HSD17B8 HGNC:3554 hydroxysteroid (17-beta) dehydrogenase 8 Q92506 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms NA HSD3B1 HGNC:5217 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 P14060 Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 8043598,7673125,11174850 endoplasmic reticulum membrane 25 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion membrane multiple Deuterostomia Bilateria Cell.Organisms HSD3B2 HGNC:5218 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 P26439 Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 8943802,8943802 endoplasmic reticulum membrane 26 1 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. mitochondrion membrane multiple Deuterostomia Bilateria Cell.Organisms HSD3B7 HGNC:18324 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Q9H2F3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11067870 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Cell.Organisms Cell.Organisms HSDL1 HGNC:16475 hydroxysteroid dehydrogenase like 1 Q3SXM5 Mitochondrion. mitochondrion 100 3 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms HSDL2 HGNC:18572 hydroxysteroid dehydrogenase like 2 Q6YN16 Peroxisome. peroxisome 100 0 peroxisome peroxisome Bilateria Cell.Organisms Cell.Organisms HSF1 HGNC:5224 heat shock transcription factor 1 Q00613 Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10867642,17081983,10867642 nucleus 65 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA HSF2 HGNC:5225 heat shock transcription factor 2 Q03933 Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1871106,1871106 nucleus 31 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota HSF2BP HGNC:5226 heat shock transcription factor 2 binding protein O75031 Nucleus (GO:0005634) nucleus 72 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa HSF4 HGNC:5227 heat shock transcription factor 4 Q9ULV5 Nucleus. Nucleus (GO:0005634) 8972228 nucleus 100 0 nucleus nucleus Theria Eukaryota Eukaryota HSF5 HGNC:26862 heat shock transcription factor family member 5 Q4G112 Nucleus (Probable). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Mammalia Euteleostomi Opisthokonta HSFX1 HGNC:29603 heat shock transcription factor family, X linked 1 Q9UBD0 Nucleus (Potential). Cytoplasm. Nucleus (GO:0005634) nucleus 27 0 cytoplasm cytoplasm Catarrhini Eutheria NA HSFX2 HGNC:32701 heat shock transcription factor family, X linked 2 Q9UBD0 Nucleus (Potential). Cytoplasm. nucleus 27 0 cytoplasm cytoplasm Catarrhini Eutheria Opisthokonta HSFY1 HGNC:18568 heat shock transcription factor, Y-linked 1 Q96LI6 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15044259,15044259 nucleus 38 0 cytoplasm. nucleus multiple Homininae Mammalia Eukaryota HSFY2 HGNC:23950 heat shock transcription factor, Y linked 2 Q96LI6 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15044259,15044259 nucleus 38 0 cytoplasm. nucleus multiple Homininae Mammalia Eukaryota HSH2D HGNC:24920 hematopoietic SH2 domain containing Q96JZ2 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11700021,11700021 cytoplasm 23 0 cytoplasm. nucleus multiple Theria Euteleostomi Holozoa HSP90AA1 HGNC:5253 heat shock protein 90kDa alpha (cytosolic), class A member 1 P07900 Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular space (GO:0005615); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 12176997,12226087,10376793,12526792,17167422,17081983,15062560,15146192,15561729,15598749 cytoplasm 84 0 cytoplasm. melanosome. mitochondrion. nucleus. secreted multiple Eukaryota Cell.Organisms Cell.Organisms HSP90AA2 HGNC:5256 heat shock protein 90kDa alpha (cytosolic), class A member 2 Q14568 Cytoplasm (By similarity). cytoplasm 81 0 cytoplasm cytoplasm NA NA NA HSP90AB1 HGNC:5258 heat shock protein 90kDa alpha (cytosolic), class B member 1 P08238 Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytosol (GO:0005829); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 10376793,10376793,15635413,16263121,15561729,15598749 cytoplasm 90 0 cytoplasm. melanosome. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms HSP90B1 HGNC:12028 heat shock protein 90kDa beta (Grp94), member 1 P14625 Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 11861214,15598749,15561729 endoplasmic reticulum 89 0 cytoplasm. endoplasmic reticulum. melanosome. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms HSPA12A HGNC:19022 heat shock 70kDa protein 12A O43301 cytoplasm 11 0 cytoplasm cytoplasm Euteleostomi Eukaryota NA HSPA12B HGNC:16193 heat shock 70kD protein 12B Q96MM6 endoplasmic reticulum 43 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Cell.Organisms HSPA13 HGNC:11375 heat shock protein 70kDa family, member 13 P48723 Microsome. Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783) 8131751 cytoplasm 31 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Bilateria Cell.Organisms HSPA14 HGNC:29526 heat shock 70kDa protein 14 Q0VDF9 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms HSPA1A HGNC:5232 heat shock 70kDa protein 1A P08107 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829); Nucleus (GO:0005634) 12935469,17081983,12865437,11790298,16263121,14517289,19059367 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA HSPA1B HGNC:5233 heat shock 70kDa protein 1B P08107 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11730740,10859165,10205060 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA HSPA1L HGNC:5234 heat shock 70kDa protein 1-like P34931 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11599570,11599570,15598749 cytoplasm 89 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota NA HSPA2 HGNC:5235 heat shock 70kDa protein 2 P54652 Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 8601336,11790298,8601336 cytoplasm 82 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms HSPA4 HGNC:5237 heat shock 70kDa protein 4 P34932 Cytoplasm (Probable). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cell surface (GO:0009986) 12485826,12485826,12485826,17167422,17167422,,19659607, cytoplasm 56 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Eukaryota Eukaryota Cell.Organisms HSPA4L HGNC:17041 heat shock 70kDa protein 4-like O95757 Cytoplasm (By similarity). Nucleus (By similarity). Note=May translocate to the nucleus after heat shock (By similarity). Cytoplasm (GO:0005737) 10524232 cytoplasm 50 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms HSPA5 HGNC:5238 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) P11021 Endoplasmic reticulum lumen. Melanosome. Cytoplasm (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Endoplasmic reticulum lumen (GO:0005788); Mitochondrion (GO:0005739); Cell surface (GO:0009986) ,9885241,15561729,19632185,,,11476899,19632185,,11943137,15635413,11790298,17215244,15598749,,19659607, endoplasmic reticulum 97 0 cytoplasm. endoplasmic reticulum. melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms HSPA6 HGNC:5239 heat shock 70kDa protein 6 (HSP70B') P17066 Nucleus (GO:0005634) 10413683 cytoplasm 78 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms HSPA8 HGNC:5241 heat shock 70kDa protein 8 P11142 Cytoplasm. Melanosome. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytosol (GO:0005829);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 14684748/14684748,2966179,7826371,7639722,17022977,14684748,15194794,2966179,7826371,7639722,8892974,17022977,15635413,11790298,14684748,2966179,7826371,15598749,15561729/14684748,2966179,7639722,7826371,14684748,15194794,2966179,7639722,7826371,8892974,14684748,15635413,2966179,7826371 cytoplasm 83 0 cytoplasm. melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms HSPA9 HGNC:5244 heat shock 70kDa protein 9 (mortalin) P38646 Mitochondrion. Nucleus, nucleolus. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Nucleolus (GO:0005730); Cell surface (GO:0009986) 11900485,7829505,15077116,15598749,12470827,12470827,12470827,15635413,11790298,,19659607, mitochondrion 89 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HSPB1 HGNC:5246 heat shock 27kDa protein 1 P04792 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Microtubule (GO:0005874) 7799959,17081983,7799959,17081983,7799959,15561729 cytoplasm 61 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms HSPB11 HGNC:25019 heat shock protein family B (small), member 11 Q9Y547 Extracellular (GO:0005576) 2018407 secreted 13 0 secreted secreted Euteleostomi Eukaryota Eukaryota HSPB2 HGNC:5247 heat shock 27kDa protein 2 Q16082 Cytoplasm. Nucleus. Note=Localizes to nuclear foci. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12897149,12473058 cytoplasm 26 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi NA HSPB3 HGNC:5248 heat shock 27kDa protein 3 Q12988 Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock. cytoplasm 27 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eumetazoa HSPB6 HGNC:26511 heat shock protein, alpha-crystallin-related, B6 O14558 Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock. cytoplasm 29 0 cytoplasm. nucleus multiple Theria Theria Eumetazoa HSPB7 HGNC:5249 heat shock 27kDa protein family, member 7 (cardiovascular) Q9UBY9 Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. cytoplasm 22 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa HSPB8 HGNC:30171 heat shock 22kDa protein 8 Q9UJY1 Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11295034,11295034 cytoplasm 30 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa HSPB9 HGNC:30589 heat shock protein, alpha-crystallin-related, B9 Q9BQS6 Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15503857,15120496,15503857,15120496 cytoplasm 73 0 cytoplasm. nucleus multiple Eutheria Eutheria NA HSPBAP1 HGNC:16389 HSPB (heat shock 27kDa) associated protein 1 Q96EW2 Cytoplasm (By similarity). cytoplasm 68 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms HSPBP1 HGNC:24989 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Q9NZL4 endoplasmic reticulum 12 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Eukaryota HSPD1 HGNC:5261 heat shock 60kDa protein 1 (chaperonin) P10809 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrial matrix (GO:0005759); Endoplasmic reticulum (GO:0005783); Peroxisomal matrix (GO:0005782); Secretory granule (GO:0030141); Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Nucleolus (GO:0005730); Cytosol (GO:0005829) 17510655,15598749,12942564,10731000,12942564,12594256,12493773,11144526,16320351,12611882,12483302,12461076,10960671,10499815,2568584,1516759,8882520,7911805,8882520,7911805,1516759,10467106,7911805,15635413,11790298,15561729 mitochondrion 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus. peroxisome. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms HSPE1 HGNC:5269 heat shock 10kDa protein 1 P61604 Mitochondrion matrix. Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 11210183,12967636,12387818,15598749,15635413 mitochondrion 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms HSPG2 HGNC:5273 heparan sulfate proteoglycan 2 P98160 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 10579711 plasma membrane 26 0 secreted secreted Bilateria Bilateria Cell.Organisms HSPH1 HGNC:16969 heat shock 105kDa/110kDa protein 1 Q92598 Cytoplasm. Cytoplasm (GO:0005737); Cytosol (GO:0005829); Nucleus (GO:0005634) 9931472,17081983,16263121,15561729,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms HTATIP2 HGNC:16637 HIV-1 Tat interactive protein 2, 30kDa Q9BUP3 Cytoplasm. Nucleus envelope. Nucleus (GO:0005634) 9482853 cytoplasm 15 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms HTATSF1 HGNC:5276 HIV-1 Tat specific factor 1 O43719 Nucleus. Nucleus (GO:0005634) 10454543 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota HTN1 HGNC:5283 histatin 1 P15515 Secreted. Extracellular (GO:0005576) 12711380,11570863 secreted 100 0 secreted secreted Homininae Homininae Eutheria HTN3 HGNC:5284 histatin 3 P15516 Secreted. Note=Secreted by serous acinar and demilune cells. Extracellular (GO:0005576) 2303595 secreted 100 0 secreted secreted Human Human Primates HTR1A HGNC:5286 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled P08908 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2052135 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Bilateria Metazoa HTR1B HGNC:5287 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled P28222 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1348246 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa HTR1D HGNC:5289 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled P28221 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1565658 plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Metazoa HTR1E HGNC:5291 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled P28566 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1733778 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Eumetazoa HTR1F HGNC:5292 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled P30939 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1328180 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa HTR2A HGNC:5293 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled P28223 Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the postsynaptic thickening of axo-dendritic synapses (By similarity). Plasma membrane (GO:0005886) 9153397 plasma membrane 45 7 plasma membrane plasma membrane Amniota Euteleostomi Metazoa HTR2B HGNC:5294 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled P41595 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8786115 plasma membrane 33 7 plasma membrane plasma membrane Euteleostomi Bilateria Eumetazoa HTR2C HGNC:5295 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled P28335 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8812491 plasma membrane 100 7 plasma membrane plasma membrane Chordata Bilateria NA HTR3A HGNC:5297 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic P46098 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12359150,12359150 plasma membrane 32 4 endoplasmic reticulum. plasma membrane multiple Tetrapoda Euteleostomi Cell.Organisms HTR3B HGNC:5298 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic O95264 Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12359150,12750374,12359150,12750374 plasma membrane 100 4 endoplasmic reticulum. plasma membrane multiple Eutheria Euteleostomi Cell.Organisms HTR3C HGNC:24003 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic Q8WXA8 Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. Plasma membrane (GO:0005886) plasma membrane 100 4 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms HTR3D HGNC:24004 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic Q70Z44 Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. plasma membrane 100 4 plasma membrane plasma membrane Human Human Eumetazoa HTR3E HGNC:24005 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic A5X5Y0 Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. Integral to membrane (GO:0016021) plasma membrane 100 4 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms HTR4 HGNC:5299 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Q13639 Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli (By similarity). Plasma membrane (GO:0005886) 8867105 plasma membrane 26 7 endosome. plasma membrane multiple Euteleostomi Bilateria Metazoa HTR5A HGNC:5300 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled P47898 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11916537 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa HTR6 HGNC:5301 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled P50406 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11888546,17189269 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa HTR7 HGNC:5302 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled P34969 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11888546 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Metazoa HTRA1 HGNC:9476 HtrA serine peptidase 1 Q92743 Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane. Extracellular (GO:0005576) 12242667 secreted 52 0 cytoplasm. secreted multiple Deuterostomia Cell.Organisms Cell.Organisms HTRA2 HGNC:14348 HtrA serine peptidase 2 O43464 Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein (Potential). Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11583623,15036614,10644717,11604410,15036614 secreted 43 2 cytoplasm. endoplasmic reticulum. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms HTRA3 HGNC:30406 HtrA serine peptidase 3 P83110 Secreted. Note=Secretion increased during decidualization of endometrial stromal cells. secreted 100 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms HTRA4 HGNC:26909 HtrA serine peptidase 4 P83105 Secreted (By similarity). secreted 42 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms HTT HGNC:4851 huntingtin P42858 Cytoplasm. Nucleus. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 12393793,12393793,11839795,12799135 secreted 36 8 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Deuterostomia Eukaryota Eukaryota HUNK HGNC:13326 hormonally up-regulated Neu-associated kinase P57058 Cytoplasm (GO:0005737) cytoplasm 22 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms HUS1 HGNC:5309 HUS1 checkpoint homolog (S. pombe) O60921 Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,10846170,15897895,,,15897895, mitochondrion 7 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota HUS1B HGNC:16485 HUS1 checkpoint homolog b (S. pombe) Q8NHY5 mitochondrion 10 0 mitochondrion mitochondrion Euarchontoglires Euarchontoglires Eukaryota HUWE1 HGNC:30892 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase Q7Z6Z7 Cytoplasm. Nucleus. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7478539,15989956,17081983,17081983 cytoplasm 33 5 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota HVCN1 HGNC:28240 hydrogen voltage-gated channel 1 Q96D96 Membrane; Multi-pass membrane protein. Note=Associates mainly with intracellular compartment membranes. Integral to membrane (GO:0016021) mitochondrion 34 4 mitochondrion mitochondrion Deuterostomia Deuterostomia Deuterostomia HYAL1 HGNC:5320 hyaluronoglucosaminidase 1 Q12794 Secreted. Lysosome. Extracellular (GO:0005576) 9223416,10339581 secreted 20 0 lysosome. secreted multiple Bilateria Bilateria NA HYAL2 HGNC:5321 hyaluronoglucosaminidase 2 Q12891 Cell membrane; Lipid-anchor, GPI-anchor. Lysosome (GO:0005764); Cell surface (GO:0009986); Extracellular (GO:0005576) 10989127,11296287,10989127 secreted 16 0 lysosome. secreted multiple Amniota Euteleostomi NA HYAL3 HGNC:5322 hyaluronoglucosaminidase 3 O43820 Secreted (By similarity). Lysosome (By similarity). secreted 18 0 secreted secreted Bilateria Bilateria NA HYAL4 HGNC:5323 hyaluronoglucosaminidase 4 Q2M3T9 Membrane; Multi-pass membrane protein (Potential). Extracellular (GO:0005576) 10989127 secreted 16 2 secreted secreted Mammalia Euteleostomi Eumetazoa HYDIN HGNC:19368 HYDIN, axonemal central pair apparatus protein Q4G0P3 nucleus 15 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota HYI HGNC:26948 hydroxypyruvate isomerase (putative) Q5T013 Nucleus (GO:0005634) cytoplasm 22 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms HYKK HGNC:34403 hydroxylysine kinase A2RU49 Cytoplasm (Potential). cytoplasm 49 1 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms HYLS1 HGNC:26558 hydrolethalus syndrome 1 Q96M11 Cytoplasm. Cytoplasm (GO:0005737) 15843405 cytoplasm 100 0 cytoplasm cytoplasm Theria Amniota Holozoa HYOU1 HGNC:16931 hypoxia up-regulated 1 Q9Y4L1 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10965054,11231630,10965054,15598749 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum. mitochondrion multiple Euteleostomi Eukaryota NA HYPK HGNC:18418 huntingtin interacting protein K Q9NX55 Nucleus. Cytoplasm. cytoplasm 53 0 cytoplasm. nucleus multiple NA NA Eukaryota IAH1 HGNC:27696 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) Q2TAA2 cytoplasm 12 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms IAPP HGNC:5329 islet amyloid polypeptide P10997 Secreted. Extracellular (GO:0005576); Lysosome (GO:0005764); Secretory granule (GO:0030141) 8605675,8771910,8307253,2546670,2189768,2546670 secreted 100 0 lysosome. secreted multiple Amniota Euteleostomi Euteleostomi IARS HGNC:5330 isoleucyl-tRNA synthetase P41252 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Ribosome (GO:0005840) 9556618,8052601,772110,9466989,15561729 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms IARS2 HGNC:29685 isoleucyl-tRNA synthetase 2, mitochondrial Q9NSE4 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739); Cytosol (GO:0005829) ,16263121 mitochondrion 24 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms IBA57 HGNC:27302 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) Q5T440 Mitochondrion (Potential). mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms IBSP HGNC:5341 integrin-binding sialoprotein P21815 Secreted. Extracellular (GO:0005576) 2461939 secreted 100 0 secreted secreted Mammalia Mammalia Amniota IBTK HGNC:17853 inhibitor of Bruton agammaglobulinemia tyrosine kinase Q9P2D0 Cytoplasm. Membrane; Peripheral membrane protein. Isoform 2: Nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11577348,11577348 nucleus 19 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms ICA1 HGNC:5343 islet cell autoantigen 1, 69kDa Q05084 Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein (Potential). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (Potential). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783);Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 8603775,8603775/12682071,12682071,12682071 cytoplasm 28 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Bilateria Bilateria Eumetazoa ICA1L HGNC:14442 islet cell autoantigen 1,69kDa-like Q8NDH6 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Bilateria Eumetazoa ICAM1 HGNC:5344 intercellular adhesion molecule 1 P05362 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 3257922,3257922,1680025 secreted 19 1 cytoplasm. plasma membrane. secreted multiple Euarchontoglires Eutheria Bilateria ICAM2 HGNC:5345 intercellular adhesion molecule 2 P13598 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2497351,9378774 secreted 50 1 plasma membrane plasma membrane Theria Theria Euteleostomi ICAM3 HGNC:5346 intercellular adhesion molecule 3 P32942 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11784723,7836774,14718574 secreted 13 1 plasma membrane. secreted multiple Catarrhini Eutheria Chordata ICAM4 HGNC:5347 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Q14773 Isoform Long: Cell membrane; Single-pass type I membrane protein. Isoform Short: Secreted. Plasma membrane (GO:0005886) 8202485,12477717,10846180,8566017 secreted 45 1 plasma membrane. secreted multiple Eutheria Eutheria Euteleostomi ICAM5 HGNC:5348 intercellular adhesion molecule 5, telencephalin Q9UMF0 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11719200,8995416 plasma membrane 10 1 plasma membrane plasma membrane Amniota Amniota Metazoa ICK HGNC:21219 intestinal cell (MAK-like) kinase Q9UPZ9 Nucleus. Cytoplasm, cytosol (By similarity). Note=Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168). Nucleus (GO:0005634) 12103360 cytoplasm 82 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms ICMT HGNC:5350 isoprenylcysteine carboxyl methyltransferase O60725 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 9614111 endoplasmic reticulum membrane 100 8 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Cell.Organisms Cell.Organisms ICOS HGNC:5351 inducible T-cell co-stimulator Q9Y6W8 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential). Plasma membrane (GO:0005886) 9930702,11169414 endoplasmic reticulum membrane 21 1 plasma membrane plasma membrane Amniota Amniota Amniota ICOSLG HGNC:17087 inducible T-cell co-stimulator ligand O75144 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 11983910,11023515 plasma membrane 14 1 plasma membrane plasma membrane Amniota Amniota Craniata ICT1 HGNC:5359 immature colon carcinoma transcript 1 Q14197 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms ID1 HGNC:5360 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein P41134 Cytoplasm (By similarity). Nucleus. Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14755252,11085505,11085505 nucleus 40 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa ID2 HGNC:5361 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein Q02363 Cytoplasm (By similarity). Nucleus. Nucleus (GO:0005634) 12878164 nucleus 53 0 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa ID3 HGNC:5362 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein Q02535 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9821964,8798572,9821964,8798572 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa ID4 HGNC:5363 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein P47928 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14633621,9418957,9418957 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa IDE HGNC:5381 insulin-degrading enzyme P14735 Cytoplasm. Cell membrane. Secreted (By similarity). Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Peroxisome (GO:0005777); Endosome (GO:0005768) 1743072,6401723,9070242,10684867,9830016,8077210,7731996,11145591 peroxisome 24 0 cytoplasm. endosome. peroxisome. secreted multiple Eukaryota Cell.Organisms Cell.Organisms IDH1 HGNC:5382 isocitrate dehydrogenase 1 (NADP+), soluble O75874 Cytoplasm. Peroxisome. Cytoplasm (GO:0005737); Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 7551812,10521434,10521434,15598749 cytoplasm 96 0 cytoplasm. mitochondrion. peroxisome multiple Eukaryota Cell.Organisms Cell.Organisms IDH2 HGNC:5383 isocitrate dehydrogenase 2 (NADP+), mitochondrial P48735 Mitochondrion. Mitochondrion (GO:0005739) 8954790,15598749 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms IDH3A HGNC:5384 isocitrate dehydrogenase 3 (NAD+) alpha P50213 Mitochondrion. Mitochondrion (GO:0005739); Extracellular (GO:0005576) none,15598749,12488461,12543931 mitochondrion 100 0 mitochondrion. secreted multiple Human Cell.Organisms Cell.Organisms IDH3B HGNC:5385 isocitrate dehydrogenase 3 (NAD+) beta O43837 Mitochondrion. Mitochondrion (GO:0005739) 10601238,15598749 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms IDH3G HGNC:5386 isocitrate dehydrogenase 3 (NAD+) gamma P51553 Mitochondrion. Mitochondrion (GO:0005739) 10601238 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Eukaryota NA IDI1 HGNC:5387 isopentenyl-diphosphate delta isomerase 1 Q13907 Peroxisome. Peroxisome (GO:0005777) 8188698 peroxisome 100 0 peroxisome peroxisome Opisthokonta Cell.Organisms Cell.Organisms IDI2 HGNC:23487 isopentenyl-diphosphate delta isomerase 2 Q9BXS1 Peroxisome. Peroxisome (GO:0005777) 14629038 peroxisome 100 0 peroxisome peroxisome Homininae Theria Cell.Organisms IDNK HGNC:31367 idnK, gluconokinase homolog (E. coli) Q5T6J7 cytoplasm 27 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms IDO1 HGNC:6059 indoleamine 2,3-dioxygenase 1 P14902 Cytoplasm (GO:0005737) 12766158 nucleus 49 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms IDO2 HGNC:27269 indoleamine 2,3-dioxygenase 2 Q6ZQW0 nucleus 42 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms IDS HGNC:5389 iduronate 2-sulfatase P22304 Lysosome. Lysosome (GO:0005764) 2222422 golgi apparatus 16 0 lysosome lysosome Deuterostomia Cell.Organisms NA IDUA HGNC:5391 iduronidase, alpha-L- P35475 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576) 1505961,11555618,11861306 cytoplasm 20 0 lysosome. secreted multiple Deuterostomia Bilateria Cell.Organisms IER2 HGNC:28871 immediate early response 2 Q9BTL4 Nucleus (GO:0005634) secreted 32 0 secreted secreted Mammalia Euteleostomi Euteleostomi IER3 HGNC:5392 immediate early response 3 P46695 Membrane; Single-pass type II membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 9791001,11455449,15855159,12356731,9791001,11455449,12356731/9703517,9878538,9703517,12743274 nucleus 49 1 cytoplasm. endoplasmic reticulum. nucleus multiple Theria Euteleostomi NA IER3IP1 HGNC:18550 immediate early response 3 interacting protein 1 Q9Y5U9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15276200 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Eukaryota Eukaryota IER5 HGNC:5393 immediate early response 5 Q5VY09 Nucleus (GO:0005634) 10049588 nucleus 17 0 nucleus nucleus Euarchontoglires Euteleostomi Bilateria IER5L HGNC:23679 immediate early response 5-like Q5T953 plasma membrane 30 0 n/a n/a Theria Euteleostomi Bilateria IFFO1 HGNC:24970 intermediate filament family orphan 1 Q0D2I5 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 6 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Olfactores IFFO2 HGNC:27006 intermediate filament family orphan 2 Q5TF58 cytoplasm 8 0 cytoplasm cytoplasm Amniota Euteleostomi Chordata IFI16 HGNC:5395 interferon, gamma-inducible protein 16 Q16666 Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10828447,12513910 nucleus 57 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eutheria IFI27 HGNC:5397 interferon, alpha-inducible protein 27 P40305 Mitochondrion. Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 90 3 mitochondrion mitochondrion Eutheria Euteleostomi Euteleostomi IFI27L1 HGNC:19754 interferon, alpha-inducible protein 27-like 1 Q96BM0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 88 3 mitochondrion membrane mitochondrion membrane Human Catarrhini Eutheria IFI27L2 HGNC:19753 interferon, alpha-inducible protein 27-like 2 Q9H2X8 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 88 0 mitochondrion membrane mitochondrion membrane Catarrhini Eutheria Euteleostomi IFI30 HGNC:5398 interferon, gamma-inducible protein 30 P13284 Secreted. Lysosome. Lysosome (GO:0005764) 16170 secreted 90 0 lysosome. secreted multiple Bilateria Eukaryota Eukaryota IFI35 HGNC:5399 interferon-induced protein 35 P80217 Nucleus. Note=Nuclear following IFN treatment. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11911807,8954125 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Craniata IFI44 HGNC:16938 interferon-induced protein 44 Q8TCB0 Cytoplasm (Potential). Cytoplasm (GO:0005737) 7925411 cytoplasm 30 0 cytoplasm cytoplasm Eutheria Eutheria Eumetazoa IFI44L HGNC:17817 interferon-induced protein 44-like Q53G44 Cytoplasm (Potential). cytoplasm 46 0 cytoplasm cytoplasm Euarchontoglires Chordata Eumetazoa IFI6 HGNC:4054 interferon, alpha-inducible protein 6 P09912 Membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) 15685448 mitochondrion membrane 82 3 mitochondrion mitochondrion Mammalia Mammalia Holozoa IFIH1 HGNC:18873 interferon induced with helicase C domain 1 Q9BYX4 Cytoplasm. Nucleus (Potential). Note=May be found in the nucleus, during apoptosis. Cytoplasm (GO:0005737) 11805321 cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Cell.Organisms IFIT1 HGNC:5407 interferon-induced protein with tetratricopeptide repeats 1 P09914 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10644362,10662616,9826176 cytoplasm 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota IFIT1B HGNC:23442 interferon-induced protein with tetratricopeptide repeats 1B Q5T764 cytoplasm 60 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms IFIT2 HGNC:5409 interferon-induced protein with tetratricopeptide repeats 2 P09913 Cytoplasm. Endoplasmic reticulum. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 3119591,17081983 cytoplasm 34 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eutheria Eutheria Craniata IFIT3 HGNC:5411 interferon-induced protein with tetratricopeptide repeats 3 O14879 Cytoplasm. Mitochondrion. Cytoplasm (GO:0005737) 9207104 cytoplasm 33 0 cytoplasm. mitochondrion multiple Euarchontoglires Eutheria Cell.Organisms IFIT5 HGNC:13328 interferon-induced protein with tetratricopeptide repeats 5 Q13325 Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface. cytoplasm 47 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms IFITM1 HGNC:5412 interferon induced transmembrane protein 1 P13164 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1383329 plasma membrane 100 2 plasma membrane plasma membrane Eutheria Deuterostomia Cell.Organisms IFITM10 HGNC:40022 interferon induced transmembrane protein 10 A6NMD0 Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 33 2 plasma membrane plasma membrane NA NA Craniata IFITM2 HGNC:5413 interferon induced transmembrane protein 2 Q01629 Cell membrane; Multi-pass membrane protein (Potential). plasma membrane 75 2 plasma membrane plasma membrane Eutheria Deuterostomia Cell.Organisms IFITM3 HGNC:5414 interferon induced transmembrane protein 3 Q01628 Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 11256614 plasma membrane 79 2 endosome membrane. lysosome membrane. plasma membrane multiple Eutheria Deuterostomia Craniata IFITM5 HGNC:16644 interferon induced transmembrane protein 5 A6NNB3 Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 74 2 plasma membrane plasma membrane Amniota Euteleostomi Craniata IFLTD1 HGNC:26683 intermediate filament tail domain containing 1 Q8N9Z9 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15688036,15688036 nucleus 14 0 cytoplasm. nucleus multiple Theria Theria Eumetazoa IFNA1 HGNC:5417 interferon, alpha 1 P01562 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted Catarrhini Catarrhini Euteleostomi IFNA10 HGNC:5418 interferon, alpha 10 P01566 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted Human Human Euteleostomi IFNA13 HGNC:5419 interferon, alpha 13 P01562 Secreted. Extracellular (GO:0005576) 1371992 secreted 100 0 secreted secreted NA NA Euteleostomi IFNA14 HGNC:5420 interferon, alpha 14 P01570 Secreted. Extracellular (GO:0005576) 1371992 secreted 100 0 secreted secreted NA NA Euteleostomi IFNA16 HGNC:5421 interferon, alpha 16 P05015 Secreted. Extracellular (GO:0005576) 1371992 secreted 100 0 secreted secreted Eutheria Euteleostomi Euteleostomi IFNA17 HGNC:5422 interferon, alpha 17 P01571 Secreted. Extracellular (GO:0005576) 1371992 secreted 100 0 secreted secreted NA NA Euteleostomi IFNA2 HGNC:5423 interferon, alpha 2 P01563 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted Catarrhini Catarrhini Euteleostomi IFNA21 HGNC:5424 interferon, alpha 21 P01568 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted Catarrhini Catarrhini Euteleostomi IFNA4 HGNC:5425 interferon, alpha 4 P05014 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted NA NA Euteleostomi IFNA5 HGNC:5426 interferon, alpha 5 P01569 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Euteleostomi Euteleostomi IFNA6 HGNC:5427 interferon, alpha 6 P05013 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted Homininae Homininae Euteleostomi IFNA7 HGNC:5428 interferon, alpha 7 P01567 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Euteleostomi Euteleostomi IFNA8 HGNC:5429 interferon, alpha 8 P32881 Secreted. Extracellular (GO:0005576) 9425112 secreted 100 0 secreted secreted Catarrhini Catarrhini Euteleostomi IFNAR1 HGNC:5432 interferon (alpha, beta and omega) receptor 1 P17181 Isoform 1: Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2153461 secreted 8 1 plasma membrane plasma membrane Amniota Euteleostomi Olfactores IFNAR2 HGNC:5433 interferon (alpha, beta and omega) receptor 2 P48551 Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8181059,7759950,7759950 secreted 68 2 plasma membrane. secreted multiple Amniota Euteleostomi Euteleostomi IFNB1 HGNC:5434 interferon, beta 1, fibroblast P01574 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Mammalia Mammalia Euteleostomi IFNE HGNC:18163 interferon, epsilon Q86WN2 Secreted (Probable). Extracellular (GO:0005576) secreted 23 0 secreted secreted Eutheria Euteleostomi Euteleostomi IFNG HGNC:5438 interferon, gamma P01579 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634) ,12165521 secreted 100 0 secreted secreted Amniota Amniota Tetrapoda IFNGR1 HGNC:5439 interferon gamma receptor 1 P15260 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11585785 secreted 11 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi IFNGR2 HGNC:5440 interferon gamma receptor 2 (interferon gamma transducer 1) P38484 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11585785 secreted 30 1 plasma membrane plasma membrane Euteleostomi Euteleostomi NA IFNK HGNC:21714 interferon, kappa Q9P0W0 Secreted. Extracellular (GO:0005576) 11514542 secreted 100 0 secreted secreted Theria Theria Euteleostomi IFNL1 HGNC:18363 interferon, lambda 1 Q8IU54 Secreted. Extracellular (GO:0005576) 12483210 secreted 100 0 secreted secreted Human Mammalia Tetrapoda IFNL2 HGNC:18364 interferon, lambda 2 Q8IZJ0 Secreted. Extracellular (GO:0005576) 12483210 secreted 100 0 secreted secreted Theria Amniota Tetrapoda IFNL3 HGNC:18365 interferon, lambda 3 Q8IZI9 Secreted. Extracellular (GO:0005576) 12483210 secreted 100 0 secreted secreted Theria Amniota Tetrapoda IFNL4 HGNC:44480 interferon, lambda 4 (gene/pseudogene) K9M1U5 Cytoplasm. Secreted. secreted 18 0 cytoplasm. secreted multiple NA NA NA IFNLR1 HGNC:18584 interferon, lambda receptor 1 Q8IU57 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 12483210 secreted 24 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi IFNW1 HGNC:5448 interferon, omega 1 P05000 Secreted. Extracellular (GO:0005576) 1693148 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi IFRD1 HGNC:5456 interferon-related developmental regulator 1 O00458 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 8028043,8028043,8028043 cytoplasm 12 1 cytoplasm. nucleus. plasma membrane multiple Chordata Eukaryota Eukaryota IFRD2 HGNC:5457 interferon-related developmental regulator 2 Q12894 Nucleus (GO:0005634) 11085536 cytoplasm 8 1 nucleus nucleus Euteleostomi Deuterostomia NA IFT122 HGNC:13556 intraflagellar transport 122 homolog (Chlamydomonas) Q9HBG6 Cytoplasm. Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Localizes to photoreceptor connecting cilia (By similarity). Cytoplasm (GO:0005737) 11242542 nucleus 11 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms IFT140 HGNC:29077 intraflagellar transport 140 homolog (Chlamydomonas) Q96RY7 Cytoplasm, cytoskeleton, cilium basal body. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms IFT172 HGNC:30391 intraflagellar transport 172 homolog (Chlamydomonas) Q9UG01 Cell projection, cilium (By similarity). Nucleus (GO:0005634) 10788441 cytoplasm 32 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms IFT20 HGNC:30989 intraflagellar transport 20 homolog (Chlamydomonas) Q8IY31 Golgi apparatus, cis-Golgi network (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia (By similarity). Centrosome (GO:0005813) 15337773 cytoplasm 61 0 cytoplasm cytoplasm Bilateria Eukaryota NA IFT22 HGNC:21895 intraflagellar transport 22 homolog (Chlamydomonas) Q9H7X7 cytoplasm 19 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota IFT27 HGNC:18626 intraflagellar transport 27 homolog (Chlamydomonas) Q9BW83 cytoplasm 17 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms IFT43 HGNC:29669 intraflagellar transport 43 homolog (Chlamydomonas) Q96FT9 Cytoplasm, cytoskeleton. Note=Associated with microtubules. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Eukaryota Opisthokonta IFT46 HGNC:26146 intraflagellar transport 46 homolog (Chlamydomonas) Q9NQC8 Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cell projection, cilium (By similarity). Note=Expression is concentrated at the cilium basal body but is also detected along the length of the cilium (By similarity). nucleus 83 0 nucleus nucleus Bilateria Eukaryota NA IFT52 HGNC:15901 intraflagellar transport 52 homolog (Chlamydomonas) Q9Y366 cytoplasm 35 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms IFT57 HGNC:17367 intraflagellar transport 57 homolog (Chlamydomonas) Q9NWB7 Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Concentrates within the inner segment of cilia (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 11788820,11788820,11788820,11788820 cytoplasm 90 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota IFT74 HGNC:21424 intraflagellar transport 74 homolog (Chlamydomonas) Q96LB3 Cytoplasmic vesicle. Note=Intracellular vesicular compartment. Intracellular vesicle (None) 11683410 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota IFT80 HGNC:29262 intraflagellar transport 80 homolog (Chlamydomonas) Q9P2H3 Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Basal body and ciliary axoneme (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms IFT81 HGNC:14313 intraflagellar transport 81 homolog (Chlamydomonas) Q8WYA0 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota IFT88 HGNC:20606 intraflagellar transport 88 homolog (Chlamydomonas) Q13099 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cytoplasm (GO:0005737) 11251073 cytoplasm 87 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms IGBP1 HGNC:5461 immunoglobulin (CD79A) binding protein 1 P78318 Cytoplasm (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11371618,11371618 nucleus 74 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota IGDCC3 HGNC:9700 immunoglobulin superfamily, DCC subclass, member 3 Q8IVU1 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9922388 plasma membrane 14 1 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms IGDCC4 HGNC:13770 immunoglobulin superfamily, DCC subclass, member 4 Q8TDY8 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 13 1 secreted secreted Euteleostomi Deuterostomia Cell.Organisms IGF1 HGNC:5464 insulin-like growth factor 1 (somatomedin C) P05019 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9853872,11857446,2752154 secreted 100 0 cytoplasm. secreted multiple Chordata Chordata Eukaryota IGF1R HGNC:5465 insulin-like growth factor 1 receptor P08069 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11250706 plasma membrane 70 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms IGF2 HGNC:5466 insulin-like growth factor 2 (somatomedin A) P01344 Secreted. Extracellular (GO:0005576) 12765950 secreted 100 0 secreted secreted Eutheria Euteleostomi Eukaryota IGF2BP1 HGNC:28866 insulin-like growth factor 2 mRNA binding protein 1 Q9NZI8 Nucleus. Cytoplasm. Cell projection, lamellipodium. Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Targeted to stress granules (SGs), but not processing bodies (PBs), during cellular stress. Colocalizes with G3BP1 and TIAL1 in SGs. Colocalizes with HIV-1 GAG at the cell edges. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Colocalized with H19 RNA at lamellipodia. Colocalized with CD44 mRNA in RNP granules. Nuclear export is mediated by XPO1/CRM1. In motile cells, is transported towards the leading edge into the cortical region of the lamellipodia where it is connected to microfilaments (By similarity). Present in the form of granules and into F-actin-rich protrusion of dendrites, spines and subsynaptic sites (By similarity). Colocalizes with beta-actin mRNA in dendrites and spines (By similarity). Exhibited rapid, bidirectional movements in dendrites and spines (By similarity). Neuronal depolarization by KCl induces its rapid efflux from the cell body into dendrites (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12921532,17081983,12921532,17081983 nucleus 15 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota IGF2BP2 HGNC:28867 insulin-like growth factor 2 mRNA binding protein 2 Q9Y6M1 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 10190901,15618018,15618018 nucleus 17 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms IGF2BP3 HGNC:28868 insulin-like growth factor 2 mRNA binding protein 3 O00425 Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9891060, nucleus 14 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms IGF2R HGNC:5467 insulin-like growth factor 2 receptor P11717 Lysosome membrane; Single-pass type I membrane protein. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2957598,9361090,9361090 endoplasmic reticulum membrane 43 1 cytoplasm. lysosome membrane. nucleus. plasma membrane multiple Deuterostomia Bilateria Eukaryota IGFALS HGNC:5468 insulin-like growth factor binding protein, acid labile subunit P35858 Secreted, extracellular space. Extracellular (GO:0005576) 1379671 secreted 100 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms IGFBP1 HGNC:5469 insulin-like growth factor binding protein 1 P08833 Secreted. Extracellular (GO:0005576) 7694877,14718574,2478445 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria IGFBP2 HGNC:5471 insulin-like growth factor binding protein 2, 36kDa P18065 Secreted. Extracellular (GO:0005576) 1716260 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria IGFBP3 HGNC:5472 insulin-like growth factor binding protein 3 P17936 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9446566,10811646,11751851,12735930 secreted 100 0 cytoplasm. nucleus. secreted multiple Amniota Euteleostomi Eumetazoa IGFBP4 HGNC:5473 insulin-like growth factor binding protein 4 P22692 Secreted. Extracellular (GO:0005576) 7689953 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Eumetazoa IGFBP5 HGNC:5474 insulin-like growth factor binding protein 5 P24593 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1710112,12777377,11821401,12777377 secreted 100 0 cytoplasm. nucleus. secreted multiple Chordata Chordata Bilateria IGFBP6 HGNC:5475 insulin-like growth factor binding protein 6 P24592 Secreted. Extracellular (GO:0005576) 10087296 secreted 100 0 secreted secreted Eutheria Euteleostomi Olfactores IGFBP7 HGNC:5476 insulin-like growth factor binding protein 7 Q16270 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8939990,10595934,10595934,10859029 secreted 100 0 cytoplasm. secreted multiple Amniota Deuterostomia Bilateria IGFBPL1 HGNC:20081 insulin-like growth factor binding protein-like 1 Q8WX77 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Theria Tetrapoda Metazoa IGFL1 HGNC:24093 IGF-like family member 1 Q6UW32 Secreted. secreted 100 0 secreted secreted Human Eutheria Eutheria IGFL2 HGNC:32929 IGF-like family member 2 Q6UWQ7 Secreted (Potential). secreted 39 0 secreted secreted Human Human Eutheria IGFL3 HGNC:32930 IGF-like family member 3 Q6UXB1 Secreted (Probable). secreted 38 0 secreted secreted Catarrhini Eutheria Eutheria IGFL4 HGNC:32931 IGF-like family member 4 Q6B9Z1 Secreted (Potential). secreted 34 0 secreted secreted Human Human Eutheria IGFLR1 HGNC:23620 IGF-like family receptor 1 Q9H665 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Theria Theria Euteleostomi IGFN1 HGNC:24607 immunoglobulin-like and fibronectin type III domain containing 1 Q86VF2 Nucleus (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). nucleus 13 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms IGHMBP2 HGNC:5542 immunoglobulin mu binding protein 2 P38935 Nucleus. Cytoplasm. Cell projection, axon (By similarity). Note=Colocalizes with the traslation initiation factor EIF4G2 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11528396,11528396 cytoplasm 20 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms IGIP HGNC:33847 IgA-inducing protein A6NJ69 Secreted (By similarity). secreted 70 0 secreted secreted Catarrhini Eutheria Eutheria IGJ HGNC:5713 immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides P01591 Secreted. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Extracellular (GO:0005576) 6417260,6774844,115892,6774844,6417260,2113434,2120591 secreted 100 0 endoplasmic reticulum. golgi apparatus. nucleus. secreted multiple Amniota Amniota Bilateria IGLL1 HGNC:5870 immunoglobulin lambda-like polypeptide 1 P15814 Secreted. Cytoplasm (GO:0005737) 10887125 secreted 100 1 cytoplasm. secreted multiple Euteleostomi Euteleostomi Cell.Organisms IGLL5 HGNC:38476 immunoglobulin lambda-like polypeptide 5 B9A064 Secreted (By similarity). secreted 68 2 n/a n/a NA NA Cell.Organisms IGLON5 HGNC:34550 IgLON family member 5 A6NGN9 Secreted (Potential). endoplasmic reticulum membrane 12 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Metazoa IGSF1 HGNC:5948 immunoglobulin superfamily, member 1 Q8N6C5 Isoform 1: Membrane; Multi-pass membrane protein (Potential). Isoform 2: Membrane; Multi-pass membrane protein (Potential). Isoform 3: Secreted (Potential). Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9521868,9729118,12874203,12067476,12397013,15680394,12724420,12724420,15680394,11782802,12414525,12757469,15183989,12397013,15680394 plasma membrane 22 3 cytoplasm. golgi apparatus. plasma membrane. secreted multiple Amniota Amniota Metazoa IGSF10 HGNC:26384 immunoglobulin superfamily, member 10 Q6WRI0 Secreted (Potential). secreted 22 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms IGSF11 HGNC:16669 immunoglobulin superfamily, member 11 Q5DX21 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 12207903 plasma membrane 86 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa IGSF21 HGNC:28246 immunoglobin superfamily, member 21 Q96ID5 Secreted (Potential). secreted 13 0 secreted secreted Euteleostomi Euteleostomi Bilateria IGSF22 HGNC:26750 immunoglobulin superfamily, member 22 Q8N9C0 plasma membrane 6 0 n/a n/a Mammalia Mammalia Cell.Organisms IGSF23 HGNC:40040 immunoglobulin superfamily, member 23 A1L1A6 Membrane; Single-pass membrane protein (Potential). secreted 22 1 secreted secreted NA NA Mammalia IGSF3 HGNC:5950 immunoglobulin superfamily, member 3 O75054 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9790749 plasma membrane 21 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria IGSF5 HGNC:5952 immunoglobulin superfamily, member 5 Q9NSI5 Cell membrane; Single-pass membrane protein (By similarity). Cell junction, tight junction (By similarity). Cell junction (GO:0030054) 12773569 secreted 12 0 secreted secreted Tetrapoda Euteleostomi Bilateria IGSF6 HGNC:5953 immunoglobulin superfamily, member 6 O95976 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9809579 plasma membrane 52 2 plasma membrane plasma membrane Amniota Amniota Euteleostomi IGSF8 HGNC:17813 immunoglobulin superfamily, member 8 Q969P0 Cell membrane (By similarity); Single-pass membrane protein. Plasma membrane (GO:0005886) 11504738 plasma membrane 88 0 n/a n/a Theria Euteleostomi Craniata IGSF9 HGNC:18132 immunoglobulin superfamily, member 9 Q9P2J2 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Note=Enriched at the excitatory synapses in mature neurons (By similarity). secreted 8 1 secreted secreted Bilateria Bilateria Metazoa IGSF9B HGNC:32326 immunoglobulin superfamily, member 9B Q9UPX0 Cell membrane; Single-pass type I membrane protein (Potential). cytoplasm 15 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms IHH HGNC:5956 indian hedgehog Q14623 Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side (By similarity). Indian hedgehog protein C-product: Secreted, extracellular space (By similarity). Note=The C-terminal peptide diffuses from the cell (By similarity). Extracellular (GO:0005576) 10462495 secreted 42 0 secreted secreted Bilateria Bilateria Holozoa IK HGNC:5958 IK cytokine, down-regulator of HLA II Q13123 Nucleus. Nucleus (GO:0005634) 10216252 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota IKBIP HGNC:26430 IKBKB interacting protein Q70UQ0 Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization. Endoplasmic reticulum (GO:0005783) 15389287 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Euteleostomi Bilateria IKBKAP HGNC:5959 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein O95163 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12058026,,11714725, cytoplasm 15 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota IKBKB HGNC:5960 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta O14920 Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytosol (GO:0005829) 11864612,11864612,,17891179,,,17891179, plasma membrane 13 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms IKBKE HGNC:14552 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon Q14164 Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent. Cytoplasm (GO:0005737) cytoplasm 37 0 cytoplasm. nucleus multiple Deuterostomia Bilateria NA IKBKG HGNC:5961 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Q9Y6K9 Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 11971901,,11971901,17891179,,17363905,,17891179,19898473, cytoplasm 13 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Deuterostomia IKZF1 HGNC:13176 IKAROS family zinc finger 1 (Ikaros) Q13422 Nucleus. Isoform Ik2: Nucleus. Isoform Ik6: Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12127581,12094252 nucleus 82 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota IKZF2 HGNC:13177 IKAROS family zinc finger 2 (Helios) Q9UKS7 Nucleus (By similarity). Nucleus (GO:0005634) 9560339 nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota IKZF3 HGNC:13178 IKAROS family zinc finger 3 (Aiolos) Q9UKT9 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9806640,11714801 nucleus 44 0 cytoplasm. nucleus multiple Amniota Amniota Eukaryota IKZF4 HGNC:13179 IKAROS family zinc finger 4 (Eos) Q9H2S9 Nucleus. Nucleus (GO:0005634) 10978333 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota IKZF5 HGNC:14283 IKAROS family zinc finger 5 (Pegasus) Q9H5V7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 16 0 nucleus nucleus Chordata Chordata Eukaryota IL10 HGNC:5962 interleukin 10 P22301 Secreted. Extracellular (GO:0005576) 11805149 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata IL10RA HGNC:5964 interleukin 10 receptor, alpha Q13651 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9312047 secreted 17 1 plasma membrane plasma membrane Amniota Amniota Euteleostomi IL10RB HGNC:5965 interleukin 10 receptor, beta Q08334 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10954742,9312047 secreted 14 1 plasma membrane plasma membrane NA NA Chordata IL11 HGNC:5966 interleukin 11 P20809 Secreted. Extracellular (GO:0005576) 10948192 secreted 100 0 secreted secreted Homininae Euteleostomi Tetrapoda IL11RA HGNC:5967 interleukin 11 receptor, alpha Q14626 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7670098 secreted 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria IL12A HGNC:5969 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) P29459 Secreted. Extracellular (GO:0005576) 1350290 secreted 100 0 secreted secreted Amniota Euteleostomi Euteleostomi IL12B HGNC:5970 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) P29460 Secreted. Extracellular (GO:0005576) 10419056 secreted 100 0 secreted secreted Amniota Euteleostomi Euteleostomi IL12RB1 HGNC:5971 interleukin 12 receptor, beta 1 P42701 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7911493,8943050 secreted 18 1 plasma membrane plasma membrane Amniota Amniota Opisthokonta IL12RB2 HGNC:5972 interleukin 12 receptor, beta 2 Q99665 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7911493 secreted 14 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Holozoa IL13 HGNC:5973 interleukin 13 P35225 Secreted. Extracellular (GO:0005576) 8097324 secreted 100 0 secreted secreted Eutheria Mammalia Eutheria IL13RA1 HGNC:5974 interleukin 13 receptor, alpha 1 P78552 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8910586,17081983 secreted 6 1 nucleus. plasma membrane multiple Human Tetrapoda Euteleostomi IL13RA2 HGNC:5975 interleukin 13 receptor, alpha 2 Q14627 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9177784 secreted 14 1 plasma membrane plasma membrane Euteleostomi Euteleostomi NA IL15 HGNC:5977 interleukin 15 P40933 Isoform IL15-S48AA: Secreted. Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components. Extracellular (GO:0005576); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783);Endosome (GO:0005768); Golgi apparatus (GO:0005794); Membrane fraction (GO:0005624);Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 9405632,10869346,10869346,9405632/12623850,10851076,10851076,10851076/9405632,9405632 secreted 95 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus. secreted multiple Amniota Amniota Amniota IL15RA HGNC:5978 interleukin 15 receptor, alpha Q13261 Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space. Integral to membrane (GO:0016021) 7641685 secreted 69 1 endoplasmic reticulum membrane. golgi apparatus membrane. nucleus membrane. secreted multiple Theria Amniota Euteleostomi IL16 HGNC:5980 interleukin 16 Q14005 Interleukin-16: Secreted. Isoform 1: Cytoplasm (By similarity). Isoform 3: Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634);Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11032842,11032842,14705216,9144227,11032842,12620798/12620798,11032842,11032842,9144227,14718574,12620798,11032842 secreted 23 0 cytoplasm. nucleus. secreted multiple Amniota Deuterostomia Holozoa IL17A HGNC:5981 interleukin 17A Q16552 Secreted. Extracellular (GO:0005576) 7499828,11936535 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Bilateria IL17B HGNC:5982 interleukin 17B Q9UHF5 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Tetrapoda Tetrapoda Chordata IL17C HGNC:5983 interleukin 17C Q9P0M4 Secreted. Extracellular (GO:0005576) 10639155 secreted 100 0 secreted secreted Chordata Chordata Chordata IL17D HGNC:5984 interleukin 17D Q8TAD2 Secreted. Extracellular (GO:0005576) 12097364 secreted 100 0 secreted secreted Amniota Euteleostomi Bilateria IL17F HGNC:16404 interleukin 17F Q96PD4 Secreted. Extracellular (GO:0005576) 11591732 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Chordata IL17RA HGNC:5985 interleukin 17 receptor A Q96F46 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 9367539 plasma membrane 12 1 plasma membrane plasma membrane Amniota Euteleostomi Bilateria IL17RB HGNC:18015 interleukin 17 receptor B Q9NRM6 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. secreted 29 1 plasma membrane. secreted multiple Theria Theria Chordata IL17RC HGNC:18358 interleukin 17 receptor C Q8NAC3 Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced. Plasma membrane (GO:0005886) 11706037 plasma membrane 100 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata IL17RD HGNC:17616 interleukin 17 receptor D Q8NFM7 Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Isoform 4: Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11802165,14742870 secreted 58 1 cytoplasm. golgi apparatus membrane. plasma membrane multiple Euteleostomi Euteleostomi Bilateria IL17RE HGNC:18439 interleukin 17 receptor E Q8NFR9 Isoform 1: Cell membrane; Single-pass type I membrane protein (By similarity). Isoform 2: Cytoplasm (Probable). Isoform 3: Secreted (Probable). Isoform 4: Cytoplasm (Probable). Isoform 5: Secreted (Probable). plasma membrane 13 1 cytoplasm. secreted multiple Mammalia Tetrapoda Euteleostomi IL17REL HGNC:33808 interleukin 17 receptor E-like Q6ZVW7 plasma membrane 15 0 n/a n/a Amniota Euteleostomi Craniata IL18 HGNC:5986 interleukin 18 (interferon-gamma-inducing factor) Q14116 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 8999548,8999548 secreted 100 0 cytoplasm. secreted multiple Amniota Amniota Euteleostomi IL18BP HGNC:5987 interleukin 18 binding protein O95998 Secreted (Potential). Extracellular (GO:0005576) 11907126,10094485 nucleus 23 0 secreted secreted Eutheria Mammalia Eutheria IL18R1 HGNC:5988 interleukin 18 receptor 1 Q13478 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9325300 plasma membrane 15 1 plasma membrane plasma membrane Amniota Amniota Eumetazoa IL18RAP HGNC:5989 interleukin 18 receptor accessory protein O95256 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 13 1 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa IL19 HGNC:5990 interleukin 19 Q9UHD0 Secreted. Extracellular (GO:0005576) 11196675 secreted 100 0 secreted secreted Theria Theria Euteleostomi IL1A HGNC:5991 interleukin 1, alpha P01583 Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 1924307,1924307,2115174 secreted 100 0 cytoplasm. secreted multiple Theria Theria Euteleostomi IL1B HGNC:5992 interleukin 1, beta P01584 Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2137098,1835838,1835838,1835838 secreted 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Craniata IL1F10 HGNC:15552 interleukin 1 family, member 10 (theta) Q8WWZ1 Secreted. Extracellular (GO:0005576) 11278614 secreted 100 0 secreted secreted Mammalia Mammalia Craniata IL1R1 HGNC:5993 interleukin 1 receptor, type I P14778 Membrane; Single-pass type I membrane protein. Cell membrane (Probable). Secreted. Plasma membrane (GO:0005886) 2530587 plasma membrane 13 1 plasma membrane. secreted multiple Amniota Euteleostomi Metazoa IL1R2 HGNC:5994 interleukin 1 receptor, type II P27930 Isoform Short: Secreted. Isoform Long: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10210771,10210771 cytoplasm 16 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Metazoa IL1RAP HGNC:5995 interleukin 1 receptor accessory protein Q9NPH3 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Plasma membrane (GO:0005886);Soluble fraction (GO:0005625) 7775431/10799889 cytoplasm 14 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Eumetazoa IL1RAPL1 HGNC:5996 interleukin 1 receptor accessory protein-like 1 Q9NZN1 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Note=May localize to the cell body and growth cones of dendrite-like processes (By similarity). Plasma membrane (GO:0005886) 8964912 plasma membrane 30 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Bilateria IL1RAPL2 HGNC:5997 interleukin 1 receptor accessory protein-like 2 Q9NP60 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11031108 plasma membrane 15 1 plasma membrane plasma membrane Euteleostomi Euteleostomi NA IL1RL1 HGNC:5998 interleukin 1 receptor-like 1 Q01638 Isoform C: Cell membrane. Isoform B: Secreted. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Soluble fraction (GO:0005625) 11478810,12355452,10936050,12578875,10936050 secreted 18 1 plasma membrane. secreted multiple Amniota Amniota Eumetazoa IL1RL2 HGNC:5999 interleukin 1 receptor-like 2 Q9HB29 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8898719 plasma membrane 14 1 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa IL1RN HGNC:6000 interleukin 1 receptor antagonist P18510 Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Extracellular (GO:0005576); Extracellular space (GO:0005615); Cytoplasm (GO:0005737) 9710237,1385987,7629520 secreted 94 0 cytoplasm. secreted multiple Mammalia Mammalia Euteleostomi IL2 HGNC:6001 interleukin 2 P60568 Secreted. Extracellular (GO:0005576) 6608729 secreted 100 0 secreted secreted Eutheria Eutheria Eutheria IL20 HGNC:6002 interleukin 20 Q9NYY1 Secreted. Extracellular (GO:0005576) 11163236 secreted 100 0 secreted secreted Amniota Euteleostomi Euteleostomi IL20RA HGNC:6003 interleukin 20 receptor, alpha Q9UHF4 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 11163236 secreted 22 1 plasma membrane plasma membrane Chordata Chordata Chordata IL20RB HGNC:6004 interleukin 20 receptor beta Q6UXL0 Membrane; Single-pass type I membrane protein (By similarity). secreted 14 2 n/a n/a Amniota Euteleostomi Euteleostomi IL21 HGNC:6005 interleukin 21 Q9HBE4 Secreted. Extracellular (GO:0005576) 11267886 secreted 100 0 secreted secreted Theria Amniota Euteleostomi IL21R HGNC:6006 interleukin 21 receptor Q9HBE5 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11081504,11016959 plasma membrane 7 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi IL22 HGNC:14900 interleukin 22 Q9GZX6 Secreted. Extracellular (GO:0005576) 10954742 secreted 100 0 secreted secreted Amniota Amniota Tetrapoda IL22RA1 HGNC:13700 interleukin 22 receptor, alpha 1 Q8N6P7 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) secreted 17 1 secreted secreted Amniota Amniota Chordata IL22RA2 HGNC:14901 interleukin 22 receptor, alpha 2 Q969J5 Secreted. Extracellular (GO:0005576) 11390454 secreted 100 0 secreted secreted Amniota Euteleostomi Chordata IL23A HGNC:15488 interleukin 23, alpha subunit p19 Q9NPF7 Secreted. Note=Secreted upon association with IL12B. Extracellular (GO:0005576) 11114383,12847224 secreted 100 0 secreted secreted Eutheria Mammalia Mammalia IL23R HGNC:19100 interleukin 23 receptor Q5VWK5 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Amniota Euteleostomi Bilateria IL24 HGNC:11346 interleukin 24 Q13007 Secreted (Potential). Extracellular (GO:0005576) 12055212,11706020,15851011 secreted 55 0 secreted secreted Eutheria Mammalia Euteleostomi IL25 HGNC:13765 interleukin 25 Q9H293 Secreted. Extracellular (GO:0005576) 11714825 secreted 100 0 secreted secreted Theria Chordata Bilateria IL26 HGNC:17119 interleukin 26 Q9NPH9 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 15178681,15178681 secreted 100 0 secreted secreted Catarrhini Mammalia Tetrapoda IL27 HGNC:19157 interleukin 27 Q8NEV9 Secreted. Note=Does not seem to be secreted without coexpression of EBI3. Extracellular (GO:0005576) 14657353 secreted 100 0 secreted secreted Theria Theria Mammalia IL27RA HGNC:17290 interleukin 27 receptor, alpha Q6UWB1 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9600072 plasma membrane 16 1 plasma membrane plasma membrane Eutheria Eutheria Euteleostomi IL2RA HGNC:6008 interleukin 2 receptor, alpha P01589 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1693645,2990220 secreted 80 1 cytoplasm. plasma membrane multiple Amniota Amniota Amniota IL2RB HGNC:6009 interleukin 2 receptor, beta P14784 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11463390 secreted 76 1 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi IL2RG HGNC:6010 interleukin 2 receptor, gamma P31785 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9797872 plasma membrane 4 1 plasma membrane plasma membrane Theria Euteleostomi Craniata IL3 HGNC:6011 interleukin 3 (colony-stimulating factor, multiple) P08700 Secreted. Extracellular (GO:0005576) 11399510 secreted 100 0 secreted secreted Catarrhini Eutheria Boreoeutheria IL31 HGNC:19372 interleukin 31 Q6EBC2 Secreted (Probable). Integral to membrane (GO:0016021) nucleus 40 0 secreted secreted Euarchontoglires Euarchontoglires Eutheria IL31RA HGNC:18969 interleukin 31 receptor A Q8NI17 Cell membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 14504285,15184896 secreted 14 1 plasma membrane plasma membrane Theria Amniota Holozoa IL32 HGNC:16830 interleukin 32 P24001 Secreted. Extracellular (GO:0005576) 1729377 secreted 100 0 secreted secreted Homininae Homininae Boreoeutheria IL33 HGNC:16028 interleukin 33 O95760 Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent. Nucleus (GO:0005634) 12819012 cytoplasm 23 0 nucleus. secreted multiple Eutheria Eutheria Eutheria IL34 HGNC:28529 interleukin 34 Q6ZMJ4 Secreted. secreted 100 0 secreted secreted Mammalia Euteleostomi Craniata IL36A HGNC:15562 interleukin 36, alpha Q9UHA7 Secreted (Potential). Extracellular (GO:0005576) 10625660 secreted 50 0 secreted secreted Theria Theria Amniota IL36B HGNC:15564 interleukin 36, beta Q9NZH7 Secreted (Potential). Extracellular (GO:0005576) 10625660 secreted 24 0 secreted secreted Mammalia Euteleostomi Euteleostomi IL36G HGNC:15741 interleukin 36, gamma Q9NZH8 Secreted. Cytoplasm (GO:0005737) 10744718 secreted 100 0 cytoplasm. secreted multiple Mammalia Euteleostomi Euteleostomi IL36RN HGNC:15561 interleukin 36 receptor antagonist Q9UBH0 Secreted. secreted 100 0 secreted secreted Mammalia Mammalia Euteleostomi IL37 HGNC:15563 interleukin 37 Q9NZH6 Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation. Extracellular (GO:0005576) 11145836 secreted 21 0 cytoplasm. nucleus. secreted multiple Human Eutheria Euteleostomi IL3RA HGNC:6012 interleukin 3 receptor, alpha (low affinity) P26951 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10515868 plasma membrane 39 1 plasma membrane plasma membrane Homininae Eutheria Euteleostomi IL4 HGNC:6014 interleukin 4 P05112 Secreted. Extracellular (GO:0005576) 12066847 secreted 100 0 secreted secreted Eutheria Eutheria Eutheria IL4I1 HGNC:19094 interleukin 4 induced 1 Q96RQ9 Isoform 1: Lysosome (By similarity). Isoform 2: Lysosome (By similarity). secreted 31 0 secreted secreted Mammalia Euteleostomi Cell.Organisms IL4R HGNC:6015 interleukin 4 receptor P24394 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 2307934/11773030 nucleus 46 1 plasma membrane. secreted multiple Amniota Amniota Euteleostomi IL5 HGNC:6016 interleukin 5 (colony-stimulating factor, eosinophil) P05113 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634) 7534492,9136909 secreted 100 0 nucleus. secreted multiple Theria Amniota Mammalia IL5RA HGNC:6017 interleukin 5 receptor, alpha Q01344 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10688814,12444154 plasma membrane 13 1 plasma membrane. secreted multiple Amniota Amniota Euteleostomi IL6 HGNC:6018 interleukin 6 (interferon, beta 2) P05231 Secreted. Extracellular (GO:0005576) 10671302 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Euteleostomi IL6R HGNC:6019 interleukin 6 receptor P08887 Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 3136546,12633863,14718574,12633863 secreted 12 1 plasma membrane. secreted multiple Theria Euteleostomi Craniata IL6ST HGNC:6021 interleukin 6 signal transducer (gp130, oncostatin M receptor) P40189 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2261637,8353278/17081983,17081983 secreted 10 1 cytoplasm. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Holozoa IL7 HGNC:6023 interleukin 7 P13232 Secreted. Extracellular (GO:0005576) 8473051 secreted 100 0 secreted secreted Eutheria Amniota Eutheria IL7R HGNC:6024 interleukin 7 receptor P16871 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 4: Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 1378163,8709637 secreted 51 1 plasma membrane. secreted multiple Amniota Euteleostomi Euteleostomi IL8 HGNC:6025 interleukin 8 P10145 Secreted. Extracellular (GO:0005576) 12388959 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata IL9 HGNC:6029 interleukin 9 P15248 Secreted. Extracellular (GO:0005576) 8756628 secreted 100 0 secreted secreted Euarchontoglires Amniota Eutheria IL9R HGNC:6030 interleukin 9 receptor Q01113 Cell membrane; Single-pass type I membrane protein. Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8756628,10329852,1376929,1376929 plasma membrane 10 2 plasma membrane. secreted multiple Eutheria Amniota Euteleostomi ILDR1 HGNC:28741 immunoglobulin-like domain containing receptor 1 Q86SU0 Cell membrane; Single-pass type I membrane protein. Isoform 5: Cytoplasm, cytosol. Plasma membrane (GO:0005886) 15381095 secreted 57 2 cytoplasm. plasma membrane multiple Theria Euteleostomi Craniata ILDR2 HGNC:18131 immunoglobulin-like domain containing receptor 2 Q71H61 Membrane; Single-pass type I membrane protein (Potential). secreted 67 2 n/a n/a Euteleostomi Euteleostomi Craniata ILF2 HGNC:6037 interleukin enhancer binding factor 2 Q12905 Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 7519613,19059367,11438540,15635413,11790298 cytoplasm 13 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa ILF3 HGNC:6038 interleukin enhancer binding factor 3, 90kDa Q12906 Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 7519613,10749851,9843854,10400669,19059367,14654356,9843854,17081983,10320367,15635413,15598749 cytoplasm 51 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Metazoa ILK HGNC:6040 integrin-linked kinase Q13418 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium (By similarity). Cytoplasm, myofibril, sarcomere. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Microsome (GO:0005792) 12060675,16221682,16221682 plasma membrane 8 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms ILKAP HGNC:15566 integrin-linked kinase-associated serine/threonine phosphatase Q9H0C8 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11331582,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms ILVBL HGNC:6041 ilvB (bacterial acetolactate synthase)-like A1L0T0 Membrane; Single-pass membrane protein. peroxisome 13 0 peroxisome peroxisome Deuterostomia Cell.Organisms Cell.Organisms IMMP1L HGNC:26317 IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) Q96LU5 Mitochondrion inner membrane (Probable). Mitochondrial membrane (GO:0005740) mitochondrion membrane 23 1 mitochondrion membrane mitochondrion membrane Euteleostomi Cell.Organisms Cell.Organisms IMMP2L HGNC:14598 IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Q96T52 Mitochondrion inner membrane; Single-pass membrane protein (Probable). mitochondrion membrane 31 1 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Cell.Organisms IMMT HGNC:6047 inner membrane protein, mitochondrial Q16891 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 9168817,15598749 cytoplasm 10 1 mitochondrion mitochondrion Bilateria Bilateria Opisthokonta IMP3 HGNC:14497 IMP3, U3 small nucleolar ribonucleoprotein Q9NV31 Nucleus, nucleolus. Nucleolus (GO:0005730) 12655004,11790298,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms IMP4 HGNC:30856 IMP4, U3 small nucleolar ribonucleoprotein Q96G21 Nucleus, nucleolus. Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 12655004,15635413,11790298,14565981 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms IMPA1 HGNC:6050 inositol(myo)-1(or 4)-monophosphatase 1 P29218 Cytoplasm. Cytoplasm (GO:0005737) 11959401 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms IMPA2 HGNC:6051 inositol(myo)-1(or 4)-monophosphatase 2 O14732 cytoplasm 44 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms IMPACT HGNC:20387 impact RWD domain protein Q9P2X3 nucleus 57 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms IMPAD1 HGNC:26019 inositol monophosphatase domain containing 1 Q9NX62 Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms IMPDH1 HGNC:6052 IMP (inosine 5'-monophosphate) dehydrogenase 1 P20839 Cytoplasm. Nucleus. Cytosol (GO:0005829) 15561729 cytoplasm 55 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms IMPDH2 HGNC:6053 IMP (inosine 5'-monophosphate) dehydrogenase 2 P12268 Cytoplasm. Nucleus. Cytosol (GO:0005829); Cytoplasm (GO:0005737) 15561729,17081983 cytoplasm 55 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms IMPG1 HGNC:6055 interphotoreceptor matrix proteoglycan 1 Q17R60 Secreted (Potential). Extracellular (GO:0005576) 9813076,10601738 nucleus 14 0 secreted secreted Human Euteleostomi Deuterostomia IMPG2 HGNC:18362 interphotoreceptor matrix proteoglycan 2 Q9BZV3 Membrane; Single-pass type I membrane protein (Potential). Extracellular (GO:0005576) 10702256 plasma membrane 25 1 secreted secreted Euteleostomi Deuterostomia Eumetazoa INA HGNC:6057 internexin neuronal intermediate filament protein, alpha Q16352 Cytoplasm (GO:0005737) 2201753 cytoplasm 35 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa INADL HGNC:28881 InaD-like (Drosophila) Q8NI35 Membrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells. Also found at the apical plasma membrane. Plasma membrane (GO:0005886); Actin cytoskeleton (GO:0015629) 11927608,17235357 cytoplasm 25 0 cytoplasm cytoplasm Mammalia Bilateria Holozoa INCA1 HGNC:32224 inhibitor of CDK, cyclin A1 interacting protein 1 Q0VD86 Nucleus. Nucleus (GO:0005634) 15159402 nucleus 100 0 nucleus nucleus Eutheria Eutheria Eutheria INCENP HGNC:6058 inner centromere protein antigens 135/155kDa Q9NQS7 Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. Centrosome (GO:0005813); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 12584241,17099693,15561729,9914378,17081983,15635413,17623812,17081983 nucleus 11 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Opisthokonta INF2 HGNC:23791 inverted formin, FH2 and WH2 domain containing Q27J81 Cytoplasm, perinuclear region. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota ING1 HGNC:6062 inhibitor of growth family, member 1 Q9UK53 Nucleus (Probable). Nucleus (GO:0005634) ,9186514,12015309,12632089,18388957, nucleus 57 0 nucleus nucleus Euteleostomi Opisthokonta Eukaryota ING2 HGNC:6063 inhibitor of growth family, member 2 Q9H160 Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm. Nucleus (GO:0005634) 16782091 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ING3 HGNC:14587 inhibitor of growth family, member 3 Q9NXR8 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota ING4 HGNC:19423 inhibitor of growth family, member 4 Q9UNL4 Nucleus. Nucleus (GO:0005634) 15029197 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ING5 HGNC:19421 inhibitor of growth family, member 5 Q8WYH8 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/12750254 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota INHA HGNC:6065 inhibin, alpha P05111 Secreted. Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 1448148,1423490,1423490 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Tetrapoda Euteleostomi Eumetazoa INHBA HGNC:6066 inhibin, beta A P08476 Secreted. Extracellular (GO:0005576) 1646080 secreted 100 0 secreted secreted Amniota Bilateria Metazoa INHBB HGNC:6067 inhibin, beta B P09529 Secreted. Extracellular (GO:0005576) 1646080 secreted 100 0 secreted secreted Euteleostomi Bilateria Metazoa INHBC HGNC:6068 inhibin, beta C P55103 Secreted (By similarity). Extracellular (GO:0005576) 1646080 secreted 26 0 secreted secreted Theria Tetrapoda Metazoa INHBE HGNC:24029 inhibin, beta E P58166 Secreted (By similarity). Extracellular (GO:0005576) 12242034 secreted 23 0 secreted secreted Eutheria Eutheria Metazoa INIP HGNC:24994 INTS3 and NABP interacting protein Q9NRY2 Nucleus. Note=Localizes to nuclear foci following DNA damage. nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Bilateria INMT HGNC:6069 indolethylamine N-methyltransferase O95050 Cytoplasm (By similarity). Extracellular (GO:0005576); Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 192352,11322482,11322482,11322482 cytoplasm 86 0 cytoplasm. endoplasmic reticulum. mitochondrion. secreted multiple NA NA Metazoa INO80 HGNC:26956 INO80 complex subunit Q9ULG1 Nucleus. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner. Nucleus (GO:0005634); Chromosome (GO:0005694) none,17081983,16230350 nucleus 100 2 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms INO80B HGNC:13324 INO80 complex subunit B Q9C086 Nucleus. Nucleus, nucleolus. Nucleus (GO:0005634); Chromosome (GO:0005694); Cytoplasm (GO:0005737) 17000644,16230350,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa INO80C HGNC:26994 INO80 complex subunit C Q6PI98 Nucleus. Chromosome (GO:0005694) 16230350 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota INO80D HGNC:25997 INO80 complex subunit D Q53TQ3 Nucleus. Chromosome (GO:0005694) 16230350 nucleus 100 0 nucleus nucleus Amniota Deuterostomia Eukaryota INO80E HGNC:26905 INO80 complex subunit E Q8NBZ0 Nucleus. Chromosome (GO:0005694) 16230350 nucleus 100 0 nucleus nucleus Mammalia Bilateria Metazoa INPP1 HGNC:6071 inositol polyphosphate-1-phosphatase P49441 Cytoplasm (GO:0005737) 8390685 golgi apparatus membrane 20 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms INPP4A HGNC:6074 inositol polyphosphate-4-phosphatase, type I, 107kDa Q96PE3 Cytoplasm (GO:0005737) 10097090 nucleus 30 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa INPP4B HGNC:6075 inositol polyphosphate-4-phosphatase, type II, 105kDa O15327 Cytoplasm (GO:0005737) 10097090 nucleus 44 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa INPP5A HGNC:6076 inositol polyphosphate-5-phosphatase, 40kDa Q14642 Membrane; Lipid-anchor. Plasma membrane (GO:0005886); Cytosol (GO:0005829) 8006039,8013665,8006039 cytoplasm 16 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota INPP5B HGNC:6077 inositol polyphosphate-5-phosphatase, 75kDa P32019 Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane (By similarity). Golgi apparatus. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Golgi membrane (GO:0000139) 7721860,2542294,8529643,8529643,7721860,10806194 cytoplasm 23 0 cytoplasm. endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. mitochondrion multiple Bilateria Eukaryota Eukaryota INPP5D HGNC:6079 inositol polyphosphate-5-phosphatase, 145kDa Q92835 Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization (By similarity). Cytoplasm (GO:0005737) 9341117,10822173 cytoplasm 29 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota INPP5E HGNC:21474 inositol polyphosphate-5-phosphatase, 72 kDa Q9NRR6 Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Peripheral membrane protein associated with Golgi stacks (By similarity). Golgi apparatus (GO:0005794); Microsome (GO:0005792) 10806194,10806194 cytoplasm 22 2 cytoplasm. golgi apparatus multiple Deuterostomia Bilateria Eukaryota INPP5F HGNC:17054 inositol polyphosphate-5-phosphatase F Q9Y2H2 endoplasmic reticulum membrane 24 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota INPP5J HGNC:8956 inositol polyphosphate-5-phosphatase J Q15735 Cytoplasm (By similarity). Note=Predominantly localized to membrane ruffles (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12536145,10593988,12536145,10593988 cytoplasm 80 1 cytoplasm. plasma membrane multiple Tetrapoda Eukaryota Eukaryota INPP5K HGNC:33882 inositol polyphosphate-5-phosphatase K Q9BT40 Endoplasmic reticulum. Note=Following stimulation with EGF, translocates to membrane ruffles. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794);Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 12556481,12556481/12536145,12536145,10753883,10753883 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Tetrapoda Euteleostomi Eukaryota INPPL1 HGNC:6080 inositol polyphosphate phosphatase-like 1 O15357 Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, lamellipodium. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11349134,11349134 cytoplasm 29 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota INS HGNC:6081 insulin P01308 Secreted. Extracellular (GO:0005576) 7716547 secreted 100 0 secreted secreted NA NA Eukaryota INSC HGNC:33116 inscuteable homolog (Drosophila) Q1MX18 Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Bilateria INSIG1 HGNC:6083 insulin induced gene 1 O15503 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane (GO:0005789); Membrane fraction (GO:0005624) 12963821,14660594,14660594 endoplasmic reticulum membrane 100 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Opisthokonta Eukaryota INSIG2 HGNC:20452 insulin induced gene 2 Q9Y5U4 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12242332 endoplasmic reticulum membrane 100 6 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Opisthokonta Eukaryota INSL3 HGNC:6086 insulin-like 3 (Leydig cell) P51460 Secreted. Extracellular (GO:0005576) 10451226 secreted 100 0 secreted secreted NA NA Mammalia INSL4 HGNC:6087 insulin-like 4 (placenta) Q14641 Secreted (By similarity). Extracellular (GO:0005576) 8702754 secreted 33 0 secreted secreted Catarrhini Catarrhini Boreoeutheria INSL5 HGNC:6088 insulin-like 5 Q9Y5Q6 Secreted. Extracellular (GO:0005576) 8702754 secreted 100 0 secreted secreted Catarrhini Eutheria Euteleostomi INSL6 HGNC:6089 insulin-like 6 Q9Y581 Secreted (By similarity). Extracellular (GO:0005576) 10598589 secreted 24 0 secreted secreted Eutheria Eutheria Eutheria INSM1 HGNC:6090 insulinoma-associated 1 Q01101 Nucleus (Potential). Nucleus (GO:0005634) 12079283 nucleus 22 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta INSM2 HGNC:17539 insulinoma-associated 2 Q96T92 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) nucleus 24 0 nucleus nucleus Eutheria Deuterostomia Eumetazoa INSR HGNC:6091 insulin receptor P06213 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11208515,3546306 plasma membrane 100 1 nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms INSRR HGNC:6093 insulin receptor-related receptor P14616 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2249481 plasma membrane 44 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms INTS1 HGNC:24555 integrator complex subunit 1 Q8N201 Nucleus membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) 16239144 nucleus 91 2 nucleus nucleus Deuterostomia Eukaryota Eukaryota INTS10 HGNC:25548 integrator complex subunit 10 Q9NVR2 Nucleus. Nucleus (GO:0005634) 16239144 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa INTS12 HGNC:25067 integrator complex subunit 12 Q96CB8 Nucleus (Probable). Nucleus (GO:0005634) plasma membrane 11 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta INTS2 HGNC:29241 integrator complex subunit 2 Q9H0H0 Nucleus membrane; Single-pass membrane protein (Potential). nucleus 55 5 nucleus nucleus Bilateria Eukaryota Eukaryota INTS3 HGNC:26153 integrator complex subunit 3 Q68E01 Nucleus. Note=Localizes to nuclear foci following DNA damage. nucleus 100 0 nucleus nucleus Bilateria Eukaryota NA INTS4 HGNC:25048 integrator complex subunit 4 Q96HW7 Nucleus (Probable). nucleus 62 0 nucleus nucleus Bilateria Eukaryota Eukaryota INTS5 HGNC:29352 integrator complex subunit 5 Q6P9B9 Nucleus. Membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634); Cytosol (GO:0005829) 16239144,15561729 secreted 39 3 cytoplasm. nucleus multiple Theria Bilateria Eumetazoa INTS6 HGNC:14879 integrator complex subunit 6 Q9UL03 Nucleus. Nucleus (GO:0005634) 11939413 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota INTS7 HGNC:24484 integrator complex subunit 7 Q9NVH2 Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner. nucleus 100 1 nucleus nucleus Deuterostomia Bilateria Eukaryota INTS8 HGNC:26048 integrator complex subunit 8 Q75QN2 Nucleus (Probable). nucleus 77 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota INTS9 HGNC:25592 integrator complex subunit 9 Q9NV88 Nucleus. Nucleus (GO:0005634) 15684398 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms INTU HGNC:29239 inturned planar cell polarity protein Q9ULD6 Cytoplasm (By similarity). Cell surface (By similarity). Note=Enriched at the apical surface in ciliated cells (By similarity). nucleus 59 0 nucleus nucleus Deuterostomia Bilateria Metazoa INVS HGNC:17870 inversin Q9Y283 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Cell projection, cilium. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle. Frequently membrane- associated, membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12221118,12221118 nucleus 17 0 nucleus nucleus Human Eukaryota Cell.Organisms IP6K1 HGNC:18360 inositol hexakisphosphate kinase 1 Q92551 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11502751,11502751 cytoplasm 44 0 cytoplasm. nucleus multiple Mammalia Opisthokonta Eukaryota IP6K2 HGNC:17313 inositol hexakisphosphate kinase 2 Q9UHH9 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 15533939,11502751,15533939 nucleus 100 0 mitochondrion. nucleus multiple Euteleostomi Bilateria Eukaryota IP6K3 HGNC:17269 inositol hexakisphosphate kinase 3 Q96PC2 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11502751,11502751 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota IPCEF1 HGNC:21204 interaction protein for cytohesin exchange factors 1 Q8WWN9 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12920129,12920129 cytoplasm 17 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota IPMK HGNC:20739 inositol polyphosphate multikinase Q8NFU5 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12027805,12027805 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota IPO11 HGNC:20628 importin 11 Q9UI26 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11032817,11032817 nucleus 8 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota IPO13 HGNC:16853 importin 13 O94829 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11447110,11447110 nucleus 6 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota IPO4 HGNC:19426 importin 4 Q8TEX9 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11823430,11823430,15561729 nucleus 18 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota IPO5 HGNC:6402 importin 5 O00410 Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Centrosome (GO:0005813) 9114010,9114010,17081983,15598749,15561729 nucleus 66 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota IPO7 HGNC:9852 importin 7 O95373 Cytoplasm. Nucleus. Nucleus (GO:0005634) none,17081983 nucleus 13 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota IPO8 HGNC:9853 importin 8 O15397 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) none,15561729 nucleus 10 0 nucleus nucleus Eukaryota Eukaryota Eukaryota IPO9 HGNC:19425 importin 9 Q96P70 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 11823430 nucleus 7 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota IPP HGNC:6108 intracisternal A particle-promoted polypeptide Q9Y573 Cytoplasm, cytoskeleton. Endoplasmic reticulum (GO:0005783) 11536049 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Tetrapoda Bilateria Cell.Organisms IPPK HGNC:14645 inositol 1,3,4,5,6-pentakisphosphate 2-kinase Q9H8X2 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 47 0 nucleus nucleus Bilateria Eukaryota Eukaryota IQCA1 HGNC:26195 IQ motif containing with AAA domain 1 Q86XH1 nucleus 21 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms IQCB1 HGNC:28949 IQ motif containing B1 Q15051 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localization to the centrosome depends on the interaction with CEP290. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Metazoa IQCC HGNC:25545 IQ motif containing C Q4KMZ1 nucleus 72 0 nucleus nucleus Eutheria Amniota Euteleostomi IQCD HGNC:25168 IQ motif containing D Q96DY2 cytoplasm 10 1 cytoplasm cytoplasm Deuterostomia Eukaryota Opisthokonta IQCE HGNC:29171 IQ motif containing E Q6IPM2 Nucleus (GO:0005634) 17081983 nucleus 16 0 nucleus nucleus Chordata Chordata Eukaryota IQCF1 HGNC:28607 IQ motif containing F1 Q8N6M8 cytoplasm 23 1 cytoplasm cytoplasm Eutheria Eutheria Eukaryota IQCF2 HGNC:31815 IQ motif containing F2 Q8IXL9 cytoplasm 22 1 cytoplasm cytoplasm Homininae Eutheria Deuterostomia IQCF3 HGNC:31816 IQ motif containing F3 P0C7M6 mitochondrion 35 1 mitochondrion mitochondrion NA NA Eutheria IQCF5 HGNC:35159 IQ motif containing F5 A8MTL0 cytoplasm 21 1 cytoplasm cytoplasm Eutheria Eutheria Eukaryota IQCF6 HGNC:35158 IQ motif containing F6 A8MYZ5 cytoplasm 19 1 cytoplasm cytoplasm Homininae Theria Mammalia IQCG HGNC:25251 IQ motif containing G Q9H095 cytoplasm 11 0 cytoplasm cytoplasm Deuterostomia Eukaryota Opisthokonta IQCH HGNC:25721 IQ motif containing H Q86VS3 nucleus 34 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms IQCJ HGNC:32406 IQ motif containing J Q1A5X6 nucleus 53 0 nucleus nucleus Amniota Euteleostomi Euteleostomi IQCK HGNC:28556 IQ motif containing K Q8N0W5 Nucleolus (GO:0005730) 11790298 nucleus 50 1 nucleus nucleus Theria Deuterostomia Metazoa IQGAP1 HGNC:6110 IQ motif containing GTPase activating protein 1 P46940 Cell membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 12377780,17081983,12900413,16622255,9712880,15598749 nucleus 13 0 cytoplasm. golgi apparatus. mitochondrion multiple Deuterostomia Eukaryota Eukaryota IQGAP2 HGNC:6111 IQ motif containing GTPase activating protein 2 Q13576 Cytoplasm (GO:0005737) 12515716 nucleus 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota IQGAP3 HGNC:20669 IQ motif containing GTPase activating protein 3 Q86VI3 Nucleus (GO:0005634) 17081983 cytoplasm 18 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota IQSEC1 HGNC:29112 IQ motif and Sec7 domain 1 Q6DN90 Cytoplasm. Nucleus. Note=At steady state, may be preferentially cytosolic. cytoplasm 62 1 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms IQSEC2 HGNC:29059 IQ motif and Sec7 domain 2 Q5JU85 Cytoplasm (Potential). cytoplasm 51 1 cytoplasm cytoplasm Bilateria Bilateria NA IQSEC3 HGNC:29193 IQ motif and Sec7 domain 3 Q9UPP2 Cytoplasm. cytoplasm 100 1 cytoplasm cytoplasm Euteleostomi Euteleostomi NA IQUB HGNC:21995 IQ motif and ubiquitin domain containing Q8NA54 Cytosol (GO:0005829) 15561729 nucleus 45 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota IRAK1 HGNC:6112 interleukin-1 receptor-associated kinase 1 P51617 Cytoplasm. Nucleus. Lipid droplet (By similarity). Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12138165,10899313 plasma membrane 21 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota NA IRAK1BP1 HGNC:17368 interleukin-1 receptor-associated kinase 1 binding protein 1 Q5VVH5 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15485901,15485901 mitochondrion 34 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa IRAK2 HGNC:6113 interleukin-1 receptor-associated kinase 2 O43187 Cytoplasm (GO:0005737) 9374458 plasma membrane 11 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms IRAK3 HGNC:17020 interleukin-1 receptor-associated kinase 3 Q9Y616 cytoplasm 13 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms IRAK4 HGNC:17967 interleukin-1 receptor-associated kinase 4 Q9NWZ3 Cytoplasm. Plasma membrane (GO:0005886) 12496252 cytoplasm 100 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms IREB2 HGNC:6115 iron-responsive element binding protein 2 P48200 Cytoplasm. Cytoplasm (GO:0005737) 7523370 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms IRF1 HGNC:6116 interferon regulatory factor 1 P10914 Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88- associated IRF1. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9742224,9742224 nucleus 54 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa IRF2 HGNC:6117 interferon regulatory factor 2 P14316 Nucleus. Nucleus (GO:0005634) 7507207 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta IRF2BP1 HGNC:21728 interferon regulatory factor 2 binding protein 1 Q8IU81 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12799427,17081983,,17081983,18511908, nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa IRF2BP2 HGNC:21729 interferon regulatory factor 2 binding protein 2 Q7Z5L9 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12799427,17081983,17081983 nucleus 44 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa IRF2BPL HGNC:14282 interferon regulatory factor 2 binding protein-like Q9H1B7 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 99 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Metazoa IRF3 HGNC:6118 interferon regulatory factor 3 Q14653 Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Nucleus (GO:0005634) 12692549 nucleus 17 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa IRF4 HGNC:6119 interferon regulatory factor 4 Q15306 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10453013,10601358 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Metazoa IRF5 HGNC:6120 interferon regulatory factor 5 Q13568 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15556946,15556946/11846976,11303025,12138184,15556946,11303025,12138184 nucleus 26 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Metazoa IRF6 HGNC:6121 interferon regulatory factor 6 O14896 Nucleus (Potential). Cytoplasm. Note=Translocates to nucleus in response to an activating signal (By similarity). Nucleus (GO:0005634) 12219090 nucleus 25 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa IRF7 HGNC:6122 interferon regulatory factor 7 Q92985 Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9786932,9786932 nucleus 30 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa IRF8 HGNC:5358 interferon regulatory factor 8 Q02556 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10092656,10092656 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa IRF9 HGNC:6131 interferon regulatory factor 9 Q00978 Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10860992,1630447,1630447,10860992 nucleus 64 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa IRG1 HGNC:33904 immunoresponsive 1 homolog (mouse) A6NK06 Mitochondrion (By similarity). mitochondrion 80 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms IRGC HGNC:28835 immunity-related GTPase family, cinema Q6NXR0 cytoplasm 80 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms IRGM HGNC:29597 immunity-related GTPase family, M A1A4Y4 Golgi apparatus membrane (By similarity). Cell membrane (By similarity). Cytoplasmic vesicle, phagosome membrane (By similarity). Cytoplasmic vesicle, autophagosome membrane (By similarity). Cell projection, phagocytic cup (By similarity). Note=Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi (By similarity). cytoplasm 79 0 cytoplasm cytoplasm NA NA Chordata IRGQ HGNC:24868 immunity-related GTPase family, Q Q8WZA9 cytoplasm 74 0 cytoplasm cytoplasm Eutheria Eutheria Eutheria IRS1 HGNC:6125 insulin receptor substrate 1 P35568 Cytoplasm (GO:0005737) 1648180,17081983 cytoplasm 34 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa IRS2 HGNC:6126 insulin receptor substrate 2 Q9Y4H2 Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11641236,17081983,17081983 cytoplasm 84 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa IRS4 HGNC:6128 insulin receptor substrate 4 O14654 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9553137,11912194,17215244,9553137,11912194 cytoplasm 42 0 cytoplasm cytoplasm Human Human Eumetazoa IRX1 HGNC:14358 iroquois homeobox 1 P78414 Nucleus (Probable). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota IRX2 HGNC:14359 iroquois homeobox 2 Q9BZI1 Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10370142, nucleus 40 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota IRX3 HGNC:14360 iroquois homeobox 3 P78415 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 39 0 nucleus nucleus Theria Bilateria Eukaryota IRX4 HGNC:6129 iroquois homeobox 4 P78413 Nucleus (Probable). Nucleus (GO:0005634) nucleus 31 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota IRX5 HGNC:14361 iroquois homeobox 5 P78411 Nucleus (Probable). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Theria Euteleostomi Eukaryota IRX6 HGNC:14675 iroquois homeobox 6 P78412 Nucleus (Probable). Nucleus (GO:0005634) nucleus 36 1 nucleus nucleus Theria Deuterostomia Eukaryota ISCA1 HGNC:28660 iron-sulfur cluster assembly 1 Q9BUE6 Mitochondrion. Mitochondrion (GO:0005739) 15262227 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms ISCA2 HGNC:19857 iron-sulfur cluster assembly 2 Q86U28 Mitochondrion (By similarity). mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ISCU HGNC:29882 iron-sulfur cluster assembly enzyme Q9H1K1 Isoform 1: Mitochondrion. Isoform 2: Cytoplasm. Nucleus. Mitochondrion (GO:0005739);Cytosol (GO:0005829); Nucleus (GO:0005634) 11060020/11060020,11060020 mitochondrion 66 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ISG15 HGNC:4053 ISG15 ubiquitin-like modifier P05161 Cytoplasm. Secreted. Note=UCRP conjugates seem to be noncovalently associated with the intermediate filaments and distributed in a punctate pattern. Also secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 8892645,12067988,7526157 cytoplasm 23 0 cytoplasm. secreted multiple Theria Euteleostomi Cell.Organisms ISG20 HGNC:6130 interferon stimulated exonuclease gene 20kDa Q96AZ6 Nucleus. Nucleus (GO:0005634) 9235947 nucleus 40 0 nucleus nucleus Mammalia Mammalia Cell.Organisms ISG20L2 HGNC:25745 interferon stimulated exonuclease gene 20kDa-like 2 Q9H9L3 Nucleus, nucleolus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota ISL1 HGNC:6132 ISL LIM homeobox 1 P61371 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1685766,1685766 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota ISL2 HGNC:18524 ISL LIM homeobox 2 Q96A47 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 95 0 nucleus nucleus Theria Eukaryota Eukaryota ISLR HGNC:6133 immunoglobulin superfamily containing leucine-rich repeat O14498 Secreted (Potential). Plasma membrane (GO:0005886) 9325048 plasma membrane 41 1 plasma membrane plasma membrane Mammalia Mammalia Cell.Organisms ISLR2 HGNC:29286 immunoglobulin superfamily containing leucine-rich repeat 2 Q6UXK2 Cell membrane; Single-pass membrane protein (By similarity). plasma membrane 86 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms ISM1 HGNC:16213 isthmin 1, angiogenesis inhibitor B1AKI9 Secreted (Potential). plasma membrane 48 0 n/a n/a Euteleostomi Euteleostomi Eumetazoa ISM2 HGNC:23176 isthmin 2 Q6H9L7 Secreted (Potential). secreted 46 0 secreted secreted Euarchontoglires Euteleostomi Bilateria ISOC1 HGNC:24254 isochorismatase domain containing 1 Q96CN7 cytoplasm 35 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms ISOC2 HGNC:26278 isochorismatase domain containing 2 Q96AB3 Mitochondrion (By similarity). Cytoplasm. Nucleus. Note=Localizes to the nucleus in the presence of CDKN2A. secreted 15 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms ISPD HGNC:37276 isoprenoid synthase domain containing A4D126 cytoplasm 47 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms IST1 HGNC:28977 increased sodium tolerance 1 homolog (yeast) P53990 Cytoplasmic vesicle. Note=Localizes to the midbody of dividing cells. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota ISX HGNC:28084 intestine-specific homeobox Q2M1V0 Nucleus (By similarity). nucleus 34 0 nucleus nucleus Theria Opisthokonta Eukaryota ISY1 HGNC:29201 ISY1 splicing factor homolog (S. cerevisiae) Q9ULR0 Nucleus (Potential). cytoplasm 57 0 cytoplasm cytoplasm NA NA Eukaryota ISYNA1 HGNC:29821 inositol-3-phosphate synthase 1 Q9NPH2 Cytoplasm (By similarity). cytoplasm 51 0 cytoplasm cytoplasm Eutheria Cell.Organisms Cell.Organisms ITCH HGNC:13890 itchy E3 ubiquitin protein ligase Q96J02 Cell membrane. Cytoplasm (By similarity). Nucleus. Note=Associates with endocytic vesicles. May be recruited to exosomes by NDFIP1. Plasma membrane (GO:0005886); Endosome (GO:0005768); Vesicle (None) 14602072,14684745,16888620,17028573,17110928 cytoplasm 74 1 endosome. nucleus. plasma membrane multiple Bilateria Opisthokonta Eukaryota ITFG1 HGNC:30697 integrin alpha FG-GAP repeat containing 1 Q8TB96 Secreted (Potential). Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12598909,12598909 plasma membrane 19 1 plasma membrane. secreted multiple Bilateria Eukaryota Eukaryota ITFG2 HGNC:30879 integrin alpha FG-GAP repeat containing 2 Q969R8 cytoplasm 44 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ITFG3 HGNC:14163 integrin alpha FG-GAP repeat containing 3 Q9H0X4 Membrane; Single-pass type II membrane protein (Potential). plasma membrane 24 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa ITGA1 HGNC:6134 integrin, alpha 1 P56199 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 8898357,8898357,10595787 secreted 15 1 cytoplasm. plasma membrane. secreted multiple Chordata Chordata Cell.Organisms ITGA10 HGNC:6135 integrin, alpha 10 O75578 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) secreted 16 1 secreted secreted Chordata Chordata NA ITGA11 HGNC:6136 integrin, alpha 11 Q9UKX5 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10486209,10486209 secreted 15 1 cytoplasm. plasma membrane multiple Chordata Chordata Cell.Organisms ITGA2 HGNC:6137 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) P17301 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9509387,9509387 secreted 21 1 cytoplasm. plasma membrane multiple Chordata Chordata Cell.Organisms ITGA2B HGNC:6138 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) P08514 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9809890,15067009,11606749 secreted 26 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ITGA3 HGNC:6139 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) P26006 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11853674,10487289 plasma membrane 27 1 cytoplasm. plasma membrane multiple Bilateria Bilateria Cell.Organisms ITGA4 HGNC:6140 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) P13612 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) ,17369818 plasma membrane 13 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms ITGA5 HGNC:6141 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) P08648 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10626908 secreted 19 1 plasma membrane plasma membrane Bilateria Bilateria Opisthokonta ITGA6 HGNC:6142 integrin, alpha 6 P23229 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2070796,15305378 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ITGA7 HGNC:6143 integrin, alpha 7 Q13683 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9570924,17081983 plasma membrane 38 1 nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms ITGA8 HGNC:6144 integrin, alpha 8 P53708 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7768999 plasma membrane 17 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ITGA9 HGNC:6145 integrin, alpha 9 Q13797 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8245132 plasma membrane 15 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms ITGAD HGNC:6146 integrin, alpha D Q13349 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8777714 secreted 20 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms ITGAE HGNC:6147 integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) P38570 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8119947 secreted 11 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms ITGAL HGNC:6148 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) P20701 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Immunological synapse (GO:0001772) 1762294,16892067,12845325,12845325,12845325,12845325 secreted 20 1 cytoplasm. plasma membrane multiple Mammalia Euteleostomi Cell.Organisms ITGAM HGNC:6149 integrin, alpha M (complement component 3 receptor 3 subunit) P11215 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 2454931 secreted 17 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms ITGAV HGNC:6150 integrin, alpha V P06756 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12082152,8120056,17081983,17081983 plasma membrane 17 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms ITGAX HGNC:6152 integrin, alpha X (complement component 3 receptor 4 subunit) P20702 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11937543 secreted 17 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms ITGB1 HGNC:6153 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) P05556 Cell membrane; Single-pass type I membrane protein. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Plasma membrane (GO:0005886); Cell surface (GO:0009986) 2572537,16917503,15146192 plasma membrane 23 1 melanosome. plasma membrane multiple Bilateria Bilateria Cell.Organisms ITGB1BP1 HGNC:23927 integrin beta 1 binding protein 1 O14713 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell membrane (By similarity). Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15703214,15703214 cytoplasm 59 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa ITGB1BP2 HGNC:6154 integrin beta 1 binding protein (melusin) 2 Q9UKP3 Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 11997396,9388239,9388239,10506186 secreted 24 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Theria Theria Eukaryota ITGB2 HGNC:6155 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) P05107 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11477072,15598749 plasma membrane 52 1 mitochondrion. plasma membrane multiple Bilateria Bilateria Cell.Organisms ITGB3 HGNC:6156 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) P05106 Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion. Plasma membrane (GO:0005886) 1967954,15067009,11606749 secreted 32 1 plasma membrane plasma membrane NA NA Cell.Organisms ITGB3BP HGNC:6157 integrin beta 3 binding protein (beta3-endonexin) Q13352 Isoform 1: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Isoform 2: Nucleus. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10490654,12244126,7593198,12244126 nucleus 29 0 cytoplasm. nucleus multiple Amniota Amniota Opisthokonta ITGB4 HGNC:6158 integrin, beta 4 P16144 Membrane; Single-pass type I membrane protein. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. Integral to membrane (GO:0016021);Nucleus (GO:0005634) 14668477,15305378/17081983 secreted 17 1 nucleus nucleus Chordata Chordata Cell.Organisms ITGB5 HGNC:6160 integrin, beta 5 P18084 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endosome (GO:0005768) 9443892,9443892,9443892 secreted 21 1 cytoplasm. endosome. plasma membrane multiple Bilateria Bilateria Cell.Organisms ITGB6 HGNC:6161 integrin, beta 6 P18564 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7626292,8081887 plasma membrane 23 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ITGB7 HGNC:6162 integrin, beta 7 P26010 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7689608,7509610 secreted 28 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ITGB8 HGNC:6163 integrin, beta 8 P26012 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1918072 secreted 19 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms ITGBL1 HGNC:6164 integrin, beta-like 1 (with EGF-like repeat domains) O95965 Secreted (Potential). Extracellular (GO:0005576) 10051402 secreted 26 0 secreted secreted Euteleostomi Euteleostomi Eukaryota ITIH1 HGNC:6166 inter-alpha-trypsin inhibitor heavy chain 1 P19827 Secreted. Extracellular (GO:0005576) 1380832,16188874 secreted 100 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms ITIH2 HGNC:6167 inter-alpha-trypsin inhibitor heavy chain 2 P19823 Secreted. Extracellular (GO:0005576) 2465147,8601712,16188874 secreted 100 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms ITIH3 HGNC:6168 inter-alpha-trypsin inhibitor heavy chain 3 Q06033 Secreted. Extracellular (GO:0005576) 11716497 secreted 100 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms ITIH4 HGNC:6169 inter-alpha-trypsin inhibitor heavy chain family, member 4 Q14624 Secreted. Extracellular (GO:0005576) 7805892,7775381,16188874 secreted 100 0 secreted secreted Deuterostomia Cell.Organisms Cell.Organisms ITIH5 HGNC:21449 inter-alpha-trypsin inhibitor heavy chain family, member 5 Q86UX2 Secreted (By similarity). secreted 24 0 secreted secreted Human Euteleostomi Cell.Organisms ITIH6 HGNC:28907 inter-alpha-trypsin inhibitor heavy chain family, member 6 Q6UXX5 Secreted (By similarity). secreted 26 0 secreted secreted Catarrhini Euteleostomi Cell.Organisms ITK HGNC:6171 IL2-inducible T-cell kinase Q08881 Cytoplasm. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8364206,10958690,10506192,11581171 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms ITLN1 HGNC:18259 intelectin 1 (galactofuranose binding) Q8WWA0 Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts (By similarity). Extracellular (GO:0005576) 11313366 secreted 63 0 secreted secreted Theria Chordata Metazoa ITLN2 HGNC:20599 intelectin 2 Q8WWU7 Secreted (Potential). secreted 64 0 secreted secreted Theria Chordata Cell.Organisms ITM2A HGNC:6173 integral membrane protein 2A O43736 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886); Endosome (GO:0005768) 9892734,10432285,10432285 secreted 32 1 endosome. plasma membrane multiple Tetrapoda Bilateria Bilateria ITM2B HGNC:6174 integral membrane protein 2B Q9Y287 Integral membrane protein 2B: Golgi apparatus membrane; Single-pass type II membrane protein. BRI2, membrane form: Cell membrane; Single- pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Bri23 peptide: Secreted. BRI2C, soluble form: Secreted. Plasma membrane (GO:0005886) 10391242 secreted 11 1 endosome membrane. golgi apparatus membrane. plasma membrane. secreted multiple Euteleostomi Deuterostomia Bilateria ITM2C HGNC:6175 integral membrane protein 2C Q9NQX7 Lysosome membrane; Single-pass type II membrane protein (By similarity). Cell membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021); Lysosome (GO:0005764); Membrane fraction (GO:0005624) 11290423,14592447,17215244 cytoplasm 8 1 lysosome. plasma membrane multiple Theria Euteleostomi Bilateria ITPA HGNC:6176 inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Q9BY32 Cytoplasm. Cytoplasm (GO:0005737) 487601 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ITPK1 HGNC:6177 inositol-tetrakisphosphate 1-kinase Q13572 nucleus 27 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota ITPKA HGNC:6178 inositol-trisphosphate 3-kinase A P23677 Cytoplasm (GO:0005737) 11468283 nucleus 42 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ITPKB HGNC:6179 inositol-trisphosphate 3-kinase B P27987 Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 12747803,12747803,12747803 nucleus 69 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Bilateria Eukaryota ITPKC HGNC:14897 inositol-trisphosphate 3-kinase C Q96DU7 Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. Cytoplasm (GO:0005737) 11085927 secreted 10 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota ITPR1 HGNC:6180 inositol 1,4,5-trisphosphate receptor, type 1 Q14643 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021) 12717445,11524429,10209024,10874040,7852357,10209024,15561729 endoplasmic reticulum membrane 100 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. plasma membrane multiple Chordata Eukaryota Eukaryota ITPR2 HGNC:6181 inositol 1,4,5-trisphosphate receptor, type 2 Q14571 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10828023,10874040 endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane. plasma membrane multiple Chordata Eukaryota Eukaryota ITPR3 HGNC:6182 inositol 1,4,5-trisphosphate receptor, type 3 Q14573 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 12606721,8288584,10874040,10828023,15561729 endoplasmic reticulum membrane 100 7 endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane multiple Chordata Eukaryota Eukaryota ITPRIP HGNC:29370 inositol 1,4,5-trisphosphate receptor interacting protein Q8IWB1 Cell membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cell projection (GO:0042995) 16990268,16990268,16990268 cytoplasm 12 1 nucleus. plasma membrane multiple Euteleostomi Euteleostomi Craniata ITPRIPL1 HGNC:29371 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 Q6GPH6 Membrane; Single-pass type I membrane protein (Potential). nucleus 26 2 nucleus nucleus Euarchontoglires Eutheria Craniata ITPRIPL2 HGNC:27257 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 Q3MIP1 Membrane; Single-pass type I membrane protein. secreted 11 2 n/a n/a Amniota Euteleostomi Craniata ITSN1 HGNC:6183 intersectin 1 (SH3 domain protein) Q15811 Endomembrane system (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell projection, lamellipodium. Membrane, clathrin-coated pit. Note=Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits (Probable). Axon (GO:0030424); Dendrite (GO:0030425); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Endosome (GO:0005768); Cytosol (GO:0005829); Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886); Caveola (GO:0005901); Cell surface (GO:0009986);Nucleus (GO:0005634) 10336464,10336464,10336464,10922467,16874303,12970366,12970366,12960435,12970366,12970366,10336464,12960435,16874303,12960435,12960435/17081983 cytoplasm 55 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms ITSN2 HGNC:6184 intersectin 2 Q9NZM3 Cytoplasm. Endosome (GO:0005768);Cytoplasm (GO:0005737) 11748279/10922467 cytoplasm 100 0 cytoplasm. endosome multiple Bilateria Bilateria Eukaryota IVD HGNC:6186 isovaleryl-CoA dehydrogenase P26440 Mitochondrion matrix. Mitochondrion (GO:0005739) 2063866,10713113,15598749 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms IVL HGNC:6187 involucrin P07476 Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 2873896,2873896 cytoplasm 100 0 cytoplasm cytoplasm Homininae Eutheria Boreoeutheria IVNS1ABP HGNC:16951 influenza virus NS1A binding protein Q9Y6Y0 Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737) 9696811,17081983 nucleus 15 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms IWS1 HGNC:25467 IWS1 homolog (S. cerevisiae) Q96ST2 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms IYD HGNC:21071 iodotyrosine deiodinase Q6PHW0 Cell membrane; Single-pass membrane protein. Integral to membrane (GO:0016021); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 15289438,15289438,15289438 plasma membrane 100 2 cytoplasm. plasma membrane multiple Tetrapoda Cell.Organisms Cell.Organisms IZUMO1 HGNC:28539 izumo sperm-egg fusion 1 Q8IYV9 Membrane; Single-pass type I membrane protein (Potential). Acrosome (GO:0001669) 15759005 secreted 22 1 lysosome lysosome Mammalia Mammalia Mammalia IZUMO2 HGNC:28518 IZUMO family member 2 Q6UXV1 Membrane; Single-pass type I membrane protein (Potential). secreted 55 1 secreted secreted Euarchontoglires Eutheria Amniota IZUMO3 HGNC:31421 IZUMO family member 3 Q5VZ72 Cell membrane; Single-pass type I membrane protein (Potential). secreted 67 1 secreted secreted Eutheria Eutheria Eutheria IZUMO4 HGNC:26950 IZUMO family member 4 Q1ZYL8 Secreted (Potential). secreted 75 0 secreted secreted Eutheria Eutheria Eutheria JADE1 HGNC:30027 jade family PHD finger 1 Q6IE81 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12169691,12169691 nucleus 36 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota JADE2 HGNC:22984 jade family PHD finger 2 Q9NQC1 nucleus 37 0 nucleus nucleus Bilateria Bilateria Eukaryota JADE3 HGNC:22982 jade family PHD finger 3 Q92613 Nucleus (GO:0005634) none,17081983 nucleus 40 0 nucleus nucleus Bilateria Bilateria Eukaryota JAG1 HGNC:6188 jagged 1 P78504 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular matrix (GO:0005578) 11157803,15258909 secreted 29 1 plasma membrane. secreted multiple Euteleostomi Bilateria Eukaryota JAG2 HGNC:6189 jagged 2 Q9Y219 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 10910909/9315665 secreted 26 1 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota JAGN1 HGNC:26926 jagunal homolog 1 (Drosophila) Q8N5M9 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 16 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Bilateria Metazoa JAK1 HGNC:6190 Janus kinase 1 P23458 Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. Cytoplasm (GO:0005737); Cytosol (GO:0005829) 11468294,15561729 plasma membrane 20 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms JAK2 HGNC:6192 Janus kinase 2 O60674 Endomembrane system; Peripheral membrane protein (By similarity). Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8756581,8756581 plasma membrane 20 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms JAK3 HGNC:6193 Janus kinase 3 P52333 Endomembrane system; Peripheral membrane protein (By similarity). Cytoplasm (By similarity). Cytoplasm (GO:0005737) 9822709 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms JAKMIP1 HGNC:26460 janus kinase and microtubule interacting protein 1 Q96N16 Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells. Endoplasmic reticulum (GO:0005783); Microtubule (GO:0005874); Membrane fraction (GO:0005624); Soluble fraction (GO:0005625) 14718537,15277531,14718537,14718537 golgi apparatus 55 0 cytoplasm. endoplasmic reticulum multiple Euteleostomi Deuterostomia Holozoa JAKMIP2 HGNC:29067 janus kinase and microtubule interacting protein 2 Q96AA8 Golgi apparatus. golgi apparatus 100 0 golgi apparatus golgi apparatus Euteleostomi Deuterostomia Eumetazoa JAKMIP3 HGNC:23523 Janus kinase and microtubule interacting protein 3 Q5VZ66 Golgi apparatus (By similarity). Integral to membrane (GO:0016021) golgi apparatus 93 1 golgi apparatus golgi apparatus Euteleostomi Deuterostomia Eumetazoa JAM2 HGNC:14686 junctional adhesion molecule 2 P57087 Cell junction, tight junction (By similarity). Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity). Plasma membrane (GO:0005886) 10779521,12953056 secreted 20 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa JAM3 HGNC:15532 junctional adhesion molecule 3 Q9BX67 Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, desmosome. Secreted, extracellular space. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts. Plasma membrane (GO:0005886) 12953056 plasma membrane 15 1 plasma membrane. secreted multiple Chordata Chordata Metazoa JARID2 HGNC:6196 jumonji, AT rich interactive domain 2 Q92833 Nucleus. Note=Colocalizes with the PRC2 complex on chromatin. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10913339,10807864,12890668 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota JAZF1 HGNC:28917 JAZF zinc finger 1 Q86VZ6 Nucleus (Potential). Nucleus (GO:0005634) 15302918 nucleus 21 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta JDP2 HGNC:17546 Jun dimerization protein 2 Q8WYK2 Nucleus (Probable). Nucleus (GO:0005634) 11602244,12707301 nucleus 40 0 nucleus nucleus Amniota Euteleostomi Eumetazoa JKAMP HGNC:20184 JNK1/MAPK8-associated membrane protein Q9P055 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Membrane fraction (GO:0005624); Cytosol (GO:0005829); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764) 16166642,16166642,16166642,16166642,16166642 endoplasmic reticulum membrane 97 7 cytoplasm. endoplasmic reticulum. lysosome. plasma membrane multiple Bilateria Bilateria Holozoa JMJD1C HGNC:12313 jumonji domain containing 1C Q15652 Nucleus (By similarity). Nucleus (GO:0005634) 14533015,17353003 nucleus 18 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota JMJD4 HGNC:25724 jumonji domain containing 4 Q9H9V9 nucleus 18 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms JMJD6 HGNC:19355 jumonji domain containing 6 Q6NYC1 Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10811223,14729065 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms JMJD7 HGNC:34397 jumonji domain containing 7 P0C870 nucleus 13 0 nucleus nucleus NA NA Cell.Organisms JMJD8 HGNC:14148 jumonji domain containing 8 Q96S16 nucleus 14 0 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms JMY HGNC:28916 junction mediating and regulatory protein, p53 cofactor Q8N9B5 Nucleus (By similarity). Cytoplasm, cytoskeleton. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil- like cells. Nucleus (GO:0005634) 10518217,17170761 golgi apparatus membrane 12 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eumetazoa JOSD1 HGNC:28953 Josephin domain containing 1 Q15040 nucleus 21 2 nucleus nucleus Bilateria Eukaryota Eukaryota JOSD2 HGNC:28853 Josephin domain containing 2 Q8TAC2 nucleus 18 2 nucleus nucleus Bilateria Eukaryota Eukaryota JPH1 HGNC:14201 junctophilin 1 Q9HDC5 Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 10891348,10949023,12135771,10949023,12777839,17081983 cytoplasm 28 1 endoplasmic reticulum. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms JPH2 HGNC:14202 junctophilin 2 Q9BR39 Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Sarcoplasmic reticulum (GO:0016529); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 17081983,17081983/10949023,10949023,10949023 cytoplasm 23 1 cytoplasm. endoplasmic reticulum. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms JPH3 HGNC:14203 junctophilin 3 Q8WXH2 Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 11694876,11694876 cytoplasm 26 1 endoplasmic reticulum. plasma membrane multiple Human Bilateria Cell.Organisms JPH4 HGNC:20156 junctophilin 4 Q96JJ6 Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). Plasma membrane (GO:0005886) cytoplasm 20 1 cytoplasm cytoplasm Theria Theria Cell.Organisms JRK HGNC:6199 Jrk homolog (mouse) O75564 Nucleus (Potential). Nucleus (GO:0005634) nucleus 14 0 nucleus nucleus NA NA NA JRKL HGNC:6200 JRK-like Q9Y4A0 Nucleus (By similarity). Nucleus (GO:0005634) 9240447 nucleus 12 0 nucleus nucleus Mammalia Opisthokonta Eukaryota JSRP1 HGNC:24963 junctional sarcoplasmic reticulum protein 1 Q96MG2 Sarcoplasmic reticulum membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes (By similarity). Sarcoplasmic reticulum (GO:0016529); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Microsome (GO:0005792) 12871958,16423849,16423849,12871958 cytoplasm 19 0 endoplasmic reticulum. nucleus multiple Eutheria Eutheria Eutheria JTB HGNC:6201 jumping translocation breakpoint O76095 Membrane; Single-pass type I membrane protein (Potential). Mitochondrion (By similarity). Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase. Plasma membrane (GO:0005886) 10321732 secreted 72 1 cytoplasm. plasma membrane multiple Bilateria Bilateria Holozoa JUN HGNC:6204 jun proto-oncogene P05412 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11278277,10188588,16876162,16511568,19059367,16511568 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta JUNB HGNC:6205 jun B proto-oncogene P17275 Nucleus. Nucleus (GO:0005634) 11036094 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta JUND HGNC:6206 jun D proto-oncogene P17535 Nucleus. Nucleus (GO:0005634) 9739985,17205062,19059367 nucleus 100 0 nucleus nucleus Human Opisthokonta Opisthokonta JUP HGNC:6207 junction plakoglobin P14923 Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cell junction (GO:0030054); Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoskeleton (GO:0005856) 2726765,12939402,17081983,2726765,16188874,7542250,8074697,12939402,12939402,17081983,15561729 secreted 20 0 cytoplasm. nucleus. secreted multiple Bilateria Eukaryota NA KAAG1 HGNC:21031 kidney associated antigen 1 Q9UBP8 secreted 36 0 secreted secreted Catarrhini Catarrhini Eutheria KAL1 HGNC:6211 Kallmann syndrome 1 sequence P23352 Cell membrane; Peripheral membrane protein. Secreted. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 8842728,8842728 secreted 27 0 secreted secreted Bilateria Bilateria Eumetazoa KALRN HGNC:4814 kalirin, RhoGEF kinase O60229 Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 9139723,9915831,9915831 cytoplasm 100 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms KANK1 HGNC:19309 KN motif and ankyrin repeat domains 1 Q14678 Cell projection, ruffle membrane. Isoform 1: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Nucleus. Cell projection, ruffle membrane. Note=Shuttles between the cytoplasm and nucleus. Cytoplasm (GO:0005737) 15596059,15823577,12133830 cytoplasm 29 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms KANK2 HGNC:29300 KN motif and ankyrin repeat domains 2 Q63ZY3 Cytoplasm. Mitochondrion. cytoplasm 24 0 cytoplasm. mitochondrion multiple Chordata Chordata Cell.Organisms KANK3 HGNC:24796 KN motif and ankyrin repeat domains 3 Q6NY19 secreted 46 0 secreted secreted Tetrapoda Bilateria Cell.Organisms KANK4 HGNC:27263 KN motif and ankyrin repeat domains 4 Q5T7N3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms KANSL1 HGNC:24565 KAT8 regulatory NSL complex subunit 1 Q7Z3B3 Nucleus. nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Holozoa KANSL1L HGNC:26310 KAT8 regulatory NSL complex subunit 1-like A0AUZ9 nucleus 23 0 nucleus nucleus Tetrapoda Tetrapoda Eumetazoa KANSL2 HGNC:26024 KAT8 regulatory NSL complex subunit 2 Q9H9L4 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota KANSL3 HGNC:25473 KAT8 regulatory NSL complex subunit 3 Q9P2N6 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms KARS HGNC:6215 lysyl-tRNA synthetase Q15046 Isoform Cytoplasmic: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted. Isoform Mitochondrial: Mitochondrion. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739);Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 15220430,15220430,15220430,15220430/10952987,10952987 cytoplasm 92 0 cytoplasm. mitochondrion. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms KAT2A HGNC:4201 K(lysine) acetyltransferase 2A Q92830 Nucleus. Nucleus (GO:0005634) 9073520,16260778 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA KAT2B HGNC:8638 K(lysine) acetyltransferase 2B Q92831 Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 12888487,14769800,12435739,9674425,12813456,11744716,16959611,11741939 nucleus 70 0 nucleus nucleus Eukaryota Eukaryota Eukaryota KAT5 HGNC:5275 K(lysine) acetyltransferase 5 Q92993 Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 12036595,10966108,15985650,9388189,14966270,10720489,10486269/11111051,11111051/11111051 nucleus 42 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota KAT6A HGNC:13013 K(lysine) acetyltransferase 6A Q92794 Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage. Nucleus (GO:0005634) 8782817,17081983 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota KAT6B HGNC:17582 K(lysine) acetyltransferase 6B Q8WYB5 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10497217/17081983,17081983 nucleus 59 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota KAT7 HGNC:17016 K(lysine) acetyltransferase 7 O95251 Nucleus, nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10438470,10930412,15963510,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Eukaryota KAT8 HGNC:17933 K(lysine) acetyltransferase 8 Q9H7Z6 Nucleus. Chromosome (By similarity). Nucleus (GO:0005634) 10786633 nucleus 100 0 nucleus nucleus Theria Eukaryota Eukaryota KATNA1 HGNC:6216 katanin p60 (ATPase containing) subunit A 1 O75449 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. Centrosome (GO:0005813) 8907702,10209026 cytoplasm 60 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms KATNAL1 HGNC:28361 katanin p60 subunit A-like 1 Q9BW62 Cytoplasm, cytoskeleton. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms KATNAL2 HGNC:25387 katanin p60 subunit A-like 2 Q8IYT4 Cytoplasm, cytoskeleton (By similarity). cytoplasm 35 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms KATNB1 HGNC:6217 katanin p80 (WD repeat containing) subunit B 1 Q9BVA0 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. Centrosome (GO:0005813); Microtubule (GO:0005874); Nucleus (GO:0005634) 8907702,10209026,15561729,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA KATNBL1 HGNC:26199 katanin p80 subunit B-like 1 Q9H079 cytoplasm 18 0 cytoplasm cytoplasm Chordata Chordata Opisthokonta KAZALD1 HGNC:25460 Kazal-type serine peptidase inhibitor domain 1 Q96I82 Secreted, extracellular space, extracellular matrix (By similarity). secreted 83 0 secreted secreted Chordata Chordata Eumetazoa KAZN HGNC:29173 kazrin, periplakin interacting protein Q674X7 Cytoplasm, cytoskeleton (By similarity). Isoform 2: Cytoplasm. Cell junction, desmosome. Nucleus. Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Isoform 4: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma mebrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures. secreted 24 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota KBTBD11 HGNC:29104 kelch repeat and BTB (POZ) domain containing 11 O94819 nucleus 16 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KBTBD12 HGNC:25731 kelch repeat and BTB (POZ) domain containing 12 Q3ZCT8 nucleus 13 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms KBTBD13 HGNC:37227 kelch repeat and BTB (POZ) domain containing 13 C9JR72 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms KBTBD2 HGNC:21751 kelch repeat and BTB (POZ) domain containing 2 Q8IY47 nucleus 15 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KBTBD3 HGNC:22934 kelch repeat and BTB (POZ) domain containing 3 Q8NAB2 nucleus 13 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KBTBD4 HGNC:23761 kelch repeat and BTB (POZ) domain containing 4 Q9NVX7 nucleus 13 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KBTBD6 HGNC:25340 kelch repeat and BTB (POZ) domain containing 6 Q86V97 nucleus 18 0 nucleus nucleus Mammalia Euteleostomi Cell.Organisms KBTBD7 HGNC:25266 kelch repeat and BTB (POZ) domain containing 7 Q8WVZ9 nucleus 20 0 nucleus nucleus Mammalia Euteleostomi Cell.Organisms KBTBD8 HGNC:30691 kelch repeat and BTB (POZ) domain containing 8 Q8NFY9 Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Translocates to the spindle apparatus during mitosis. Nucleus (GO:0005634) nucleus 17 0 cytoplasm. golgi apparatus multiple Euteleostomi Deuterostomia Cell.Organisms KCMF1 HGNC:20589 potassium channel modulatory factor 1 Q9P0J7 Nucleus (GO:0005634) 12810064 golgi apparatus 43 0 nucleus nucleus Euteleostomi Bilateria Eukaryota KCNA1 HGNC:6218 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) Q09470 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11097830 plasma membrane 72 7 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNA10 HGNC:6219 potassium voltage-gated channel, shaker-related subfamily, member 10 Q16322 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10836990 plasma membrane 61 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNA2 HGNC:6220 potassium voltage-gated channel, shaker-related subfamily, member 2 P16389 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 9635436,12151401,10896669 plasma membrane 72 7 endoplasmic reticulum. plasma membrane multiple Bilateria Eukaryota Cell.Organisms KCNA3 HGNC:6221 potassium voltage-gated channel, shaker-related subfamily, member 3 P22001 Cell membrane (By similarity); Multi-pass membrane protein. Plasma membrane (GO:0005886) 12604782,14745040,12632187 plasma membrane 96 7 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNA4 HGNC:6222 potassium voltage-gated channel, shaker-related subfamily, member 4 P22459 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2001794 plasma membrane 66 7 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNA5 HGNC:6224 potassium voltage-gated channel, shaker-related subfamily, member 5 P22460 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1986382,11149959,10812072 plasma membrane 74 7 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNA6 HGNC:6225 potassium voltage-gated channel, shaker-related subfamily, member 6 P17658 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2347305 plasma membrane 69 7 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNA7 HGNC:6226 potassium voltage-gated channel, shaker-related subfamily, member 7 Q96RP8 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 11368907 plasma membrane 63 7 plasma membrane plasma membrane Theria Theria Cell.Organisms KCNAB1 HGNC:6228 potassium voltage-gated channel, shaker-related subfamily, beta member 1 Q14722 Cytoplasm (Potential). Cytoplasm (GO:0005737) 9857044 cytoplasm 11 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms KCNAB2 HGNC:6229 potassium voltage-gated channel, shaker-related subfamily, beta member 2 Q13303 Cytoplasm (Potential). Cytoplasm (GO:0005737) 7649300 mitochondrion 13 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms KCNAB3 HGNC:6230 potassium voltage-gated channel, shaker-related subfamily, beta member 3 O43448 Cytoplasm (Potential). Cytoplasm (GO:0005737) 7649300 cytoplasm 12 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms KCNB1 HGNC:6231 potassium voltage-gated channel, Shab-related subfamily, member 1 Q14721 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12060745,12615930 plasma membrane 36 7 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms KCNB2 HGNC:6232 potassium voltage-gated channel, Shab-related subfamily, member 2 Q92953 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9612272 plasma membrane 36 7 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms KCNC1 HGNC:6233 potassium voltage-gated channel, Shaw-related subfamily, member 1 P48547 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 28 8 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNC2 HGNC:6234 potassium voltage-gated channel, Shaw-related subfamily, member 2 Q96PR1 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 30 6 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNC3 HGNC:6235 potassium voltage-gated channel, Shaw-related subfamily, member 3 Q14003 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 30 6 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNC4 HGNC:6236 potassium voltage-gated channel, Shaw-related subfamily, member 4 Q03721 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1920536 plasma membrane 26 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCND1 HGNC:6237 potassium voltage-gated channel, Shal-related subfamily, member 1 Q9NSA2 Membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity). Plasma membrane (GO:0005886) 10729221 plasma membrane 28 7 plasma membrane plasma membrane Bilateria Cell.Organisms NA KCND2 HGNC:6238 potassium voltage-gated channel, Shal-related subfamily, member 2 Q9NZV8 Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression. Plasma membrane (GO:0005886) 10551270 plasma membrane 25 7 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms KCND3 HGNC:6239 potassium voltage-gated channel, Shal-related subfamily, member 3 Q9UK17 Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma (By similarity). Cell projection, dendrite (By similarity). Plasma membrane (GO:0005886) 12928444 plasma membrane 24 7 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms KCNE1 HGNC:6240 potassium voltage-gated channel, Isk-related family, member 1 P15382 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11891569 endoplasmic reticulum membrane 18 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Euteleostomi KCNE1L HGNC:6241 KCNE1-like Q9UJ90 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 10493825,10493825 mitochondrion membrane 30 1 mitochondrion. plasma membrane multiple Eutheria Tetrapoda Tetrapoda KCNE2 HGNC:6242 potassium voltage-gated channel, Isk-related family, member 2 Q9Y6J6 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12185453,12185453 mitochondrion membrane 3 1 plasma membrane. secreted multiple Amniota Amniota Euteleostomi KCNE3 HGNC:6243 potassium voltage-gated channel, Isk-related family, member 3 Q9Y6H6 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11207363,11680623,10646604,10646604 mitochondrion membrane 29 1 cytoplasm. plasma membrane multiple Tetrapoda Tetrapoda Tetrapoda KCNE4 HGNC:6244 potassium voltage-gated channel, Isk-related family, member 4 Q8WWG9 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12944270 nucleus 37 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata KCNF1 HGNC:6246 potassium voltage-gated channel, subfamily F, member 1 Q9H3M0 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 24 6 plasma membrane plasma membrane Chordata Cell.Organisms Cell.Organisms KCNG1 HGNC:6248 potassium voltage-gated channel, subfamily G, member 1 Q9UIX4 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 54 6 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNG2 HGNC:6249 potassium voltage-gated channel, subfamily G, member 2 Q9UJ96 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 50 8 plasma membrane plasma membrane Catarrhini Eutheria Cell.Organisms KCNG3 HGNC:18306 potassium voltage-gated channel, subfamily G, member 3 Q8TAE7 Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 12060745,12060745 plasma membrane 32 6 endoplasmic reticulum. plasma membrane multiple Amniota Euteleostomi Cell.Organisms KCNG4 HGNC:19697 potassium voltage-gated channel, subfamily G, member 4 Q8TDN1 Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12060745,12060745 plasma membrane 100 6 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms KCNH1 HGNC:6250 potassium voltage-gated channel, subfamily H (eag-related), member 1 O95259 Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Note=Perinuclear KCNH1 is located to NPC-free islands. Plasma membrane (GO:0005886) 9738473,10880439 plasma membrane 36 6 nucleus membrane. plasma membrane multiple Bilateria Eukaryota Cell.Organisms KCNH2 HGNC:6251 potassium voltage-gated channel, subfamily H (eag-related), member 2 Q12809 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11953308,12021266,11953308,12021266,11953308 plasma membrane 100 6 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms KCNH3 HGNC:6252 potassium voltage-gated channel, subfamily H (eag-related), member 3 Q9ULD8 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12890647 plasma membrane 32 7 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms KCNH4 HGNC:6253 potassium voltage-gated channel, subfamily H (eag-related), member 4 Q9UQ05 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12890647 plasma membrane 37 7 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms KCNH5 HGNC:6254 potassium voltage-gated channel, subfamily H (eag-related), member 5 Q8NCM2 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 34 6 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNH6 HGNC:18862 potassium voltage-gated channel, subfamily H (eag-related), member 6 Q9H252 Membrane; Multi-pass membrane protein. plasma membrane 66 6 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNH7 HGNC:18863 potassium voltage-gated channel, subfamily H (eag-related), member 7 Q9NS40 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 63 6 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KCNH8 HGNC:18864 potassium voltage-gated channel, subfamily H (eag-related), member 8 Q96L42 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12890647 plasma membrane 37 7 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms KCNIP1 HGNC:15521 Kv channel interacting protein 1 Q9NZI2 Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737) 10676964 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota KCNIP2 HGNC:15522 Kv channel interacting protein 2 Q9NS61 Isoform 1: Cell membrane; Lipid-anchor (By similarity). Isoform 2: Cell membrane; Lipid-anchor (By similarity). Isoform 6: Cell membrane; Lipid-anchor (By similarity). Plasma membrane (GO:0005886);Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11287421/11263977/11747815,12135940 cytoplasm 17 0 nucleus nucleus Human Eukaryota Cell.Organisms KCNIP3 HGNC:15523 Kv channel interacting protein 3, calsenilin Q9Y2W7 Cytoplasm. Cell membrane; Lipid-anchor (By similarity). Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 9771752,11278424,11278424,12006572 cytoplasm 21 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Theria Chordata Cell.Organisms KCNIP4 HGNC:30083 Kv channel interacting protein 4 Q6PIL6 Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 11847232,11847232,11847232 cytoplasm 17 0 cytoplasm. endoplasmic reticulum. nucleus multiple Tetrapoda Eukaryota Cell.Organisms KCNJ1 HGNC:6255 potassium inwardly-rectifying channel, subfamily J, member 1 P48048 Cell membrane; Multi-pass membrane protein. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. Plasma membrane (GO:0005886) 8621594 plasma membrane 100 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNJ10 HGNC:6256 potassium inwardly-rectifying channel, subfamily J, member 10 P78508 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11927671 plasma membrane 42 2 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms KCNJ11 HGNC:6257 potassium inwardly-rectifying channel, subfamily J, member 11 Q14654 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Cell surface (GO:0009986) 12388475,14642445,16902404 plasma membrane 34 2 mitochondrion. plasma membrane multiple Mammalia Euteleostomi Cell.Organisms KCNJ12 HGNC:6258 potassium inwardly-rectifying channel, subfamily J, member 12 Q14500 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12417321,14960569,12794312 plasma membrane 38 2 nucleus. plasma membrane multiple Bilateria Eukaryota NA KCNJ13 HGNC:6259 potassium inwardly-rectifying channel, subfamily J, member 13 O60928 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10455019 plasma membrane 26 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNJ14 HGNC:6260 potassium inwardly-rectifying channel, subfamily J, member 14 Q9UNX9 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10942728 plasma membrane 30 2 plasma membrane plasma membrane Eutheria Euteleostomi Cell.Organisms KCNJ15 HGNC:6261 potassium inwardly-rectifying channel, subfamily J, member 15 Q99712 Membrane; Multi-pass membrane protein. Basolateral membrane (GO:0016323) 11804844 plasma membrane 38 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNJ16 HGNC:6262 potassium inwardly-rectifying channel, subfamily J, member 16 Q9NPI9 Membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11988170,11988170 plasma membrane 25 2 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms KCNJ18 HGNC:39080 potassium inwardly-rectifying channel, subfamily J, member 18 B7U540 Cell membrane; Multi-pass membrane protein (Probable). plasma membrane 36 2 plasma membrane plasma membrane NA NA NA KCNJ2 HGNC:6263 potassium inwardly-rectifying channel, subfamily J, member 2 P63252 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Cytosol (GO:0005829) 11287423,11287009,11287009,16895905,16895905 plasma membrane 31 2 cytoplasm. endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms KCNJ3 HGNC:6264 potassium inwardly-rectifying channel, subfamily J, member 3 P48549 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10889209 plasma membrane 35 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNJ4 HGNC:6265 potassium inwardly-rectifying channel, subfamily J, member 4 P48050 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane (By similarity). Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization (By similarity). Integral to membrane (GO:0016021); Plasma membrane (GO:0005886) 11306688,11713246,11742811 plasma membrane 37 2 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms KCNJ5 HGNC:6266 potassium inwardly-rectifying channel, subfamily J, member 5 P48544 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023); Endosome (GO:0005768) 11879649,11879649,11879649,11879649,11879649 plasma membrane 32 2 cytoplasm. endoplasmic reticulum. endosome. plasma membrane multiple Chordata Chordata Cell.Organisms KCNJ6 HGNC:6267 potassium inwardly-rectifying channel, subfamily J, member 6 P48051 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10562331,7926018 plasma membrane 33 2 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms KCNJ8 HGNC:6269 potassium inwardly-rectifying channel, subfamily J, member 8 Q15842 Membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9434770,12738227,11984590,17081983 plasma membrane 32 2 cytoplasm. mitochondrion. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms KCNJ9 HGNC:6270 potassium inwardly-rectifying channel, subfamily J, member 9 Q92806 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10341034 plasma membrane 31 2 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms KCNK1 HGNC:6272 potassium channel, subfamily K, member 1 O00180 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12855359,12855359 plasma membrane 26 6 cytoplasm. plasma membrane multiple Euteleostomi Bilateria Opisthokonta KCNK10 HGNC:6273 potassium channel, subfamily K, member 10 P57789 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 21 6 plasma membrane plasma membrane Tetrapoda Deuterostomia Cell.Organisms KCNK12 HGNC:6274 potassium channel, subfamily K, member 12 Q9HB15 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11060316 plasma membrane 23 6 plasma membrane plasma membrane Euteleostomi Bilateria Opisthokonta KCNK13 HGNC:6275 potassium channel, subfamily K, member 13 Q9HB14 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11060316 plasma membrane 19 6 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota KCNK15 HGNC:13814 potassium channel, subfamily K, member 15 Q9H427 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11409881 plasma membrane 22 5 plasma membrane plasma membrane Theria Theria Cell.Organisms KCNK16 HGNC:14464 potassium channel, subfamily K, member 16 Q96T55 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11263999 plasma membrane 20 6 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms KCNK17 HGNC:14465 potassium channel, subfamily K, member 17 Q96T54 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11263999 plasma membrane 20 6 plasma membrane plasma membrane Catarrhini Euteleostomi Cell.Organisms KCNK18 HGNC:19439 potassium channel, subfamily K, member 18 Q7Z418 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12754259,15123670 plasma membrane 100 6 plasma membrane plasma membrane Eutheria Bilateria Cell.Organisms KCNK2 HGNC:6277 potassium channel, subfamily K, member 2 O95069 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 15685212,10744694 plasma membrane 29 6 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNK3 HGNC:6278 potassium channel, subfamily K, member 3 O14649 Membrane; Multi-pass membrane protein (Potential). plasma membrane 20 5 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNK4 HGNC:6279 potassium channel, subfamily K, member 4 Q9NYG8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 22 5 plasma membrane plasma membrane Eutheria Euteleostomi Eukaryota KCNK5 HGNC:6280 potassium channel, subfamily K, member 5 O95279 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 23 6 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms KCNK6 HGNC:6281 potassium channel, subfamily K, member 6 Q9Y257 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10206991,10206991 plasma membrane 29 6 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms KCNK7 HGNC:6282 potassium channel, subfamily K, member 7 Q9Y2U2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 24 5 plasma membrane plasma membrane Eutheria Mammalia Metazoa KCNK9 HGNC:6283 potassium channel, subfamily K, member 9 Q9NPC2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 18 5 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNMA1 HGNC:6284 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Q12791 Membrane; Multi-pass membrane protein. Cell surface (GO:0009986); Axon (GO:0030424) 16042390,15251455 plasma membrane 100 9 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms KCNMB1 HGNC:6285 potassium large conductance calcium-activated channel, subfamily M, beta member 1 Q16558 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) ,16002321 endoplasmic reticulum membrane 11 2 plasma membrane plasma membrane Amniota Amniota Chordata KCNMB2 HGNC:6286 potassium large conductance calcium-activated channel, subfamily M, beta member 2 Q9Y691 Membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10097176,14522958 golgi apparatus membrane 20 2 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Eumetazoa KCNMB3 HGNC:6287 potassium large conductance calcium-activated channel, subfamily M beta member 3 Q9NPA1 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 13 2 plasma membrane plasma membrane Mammalia Euteleostomi Bilateria KCNMB4 HGNC:6289 potassium large conductance calcium-activated channel, subfamily M, beta member 4 Q86W47 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) endoplasmic reticulum membrane 12 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Eumetazoa KCNN1 HGNC:6290 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Q92952 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8781233 plasma membrane 13 7 plasma membrane plasma membrane Bilateria Bilateria Eukaryota KCNN2 HGNC:6291 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Q9H2S1 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 11395478,10713270,10991935,11395478 plasma membrane 11 7 endoplasmic reticulum. plasma membrane multiple Bilateria Bilateria Cell.Organisms KCNN3 HGNC:6292 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Q9UGI6 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634);Plasma membrane (GO:0005886) 11395478,11395478,14638680,11395478,11395478/14638680 secreted 16 7 cytoplasm. endoplasmic reticulum. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms KCNN4 HGNC:6293 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 O15554 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12493744 plasma membrane 15 8 plasma membrane plasma membrane Euarchontoglires Mammalia Eumetazoa KCNQ1 HGNC:6294 potassium voltage-gated channel, KQT-like subfamily, member 1 P51787 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 8900283 plasma membrane 35 6 plasma membrane plasma membrane Eutheria Bilateria Cell.Organisms KCNQ2 HGNC:6296 potassium voltage-gated channel, KQT-like subfamily, member 2 O43526 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886);Endoplasmic reticulum (GO:0005783) 15304482,12223552/11160379 plasma membrane 50 8 endoplasmic reticulum. plasma membrane multiple Chordata Cell.Organisms Cell.Organisms KCNQ3 HGNC:6297 potassium voltage-gated channel, KQT-like subfamily, member 3 O43525 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10781098 plasma membrane 44 7 plasma membrane plasma membrane Chordata Cell.Organisms Cell.Organisms KCNQ4 HGNC:6298 potassium voltage-gated channel, KQT-like subfamily, member 4 P56696 Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells (By similarity). Plasma membrane (GO:0005886) 10025409 plasma membrane 100 6 plasma membrane plasma membrane Chordata Cell.Organisms Cell.Organisms KCNQ5 HGNC:6299 potassium voltage-gated channel, KQT-like subfamily, member 5 Q9NR82 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15304482,12032157 plasma membrane 61 6 plasma membrane plasma membrane Chordata Cell.Organisms Cell.Organisms KCNRG HGNC:18893 potassium channel regulator Q8N5I3 Endoplasmic reticulum. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Tetrapoda Tetrapoda Eukaryota KCNS1 HGNC:6300 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 Q96KK3 Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. Plasma membrane (GO:0005886) plasma membrane 100 6 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms KCNS2 HGNC:6301 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 Q9ULS6 Cell membrane; Multi-pass membrane protein (By similarity). Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (By similarity). Plasma membrane (GO:0005886) 9305895 plasma membrane 98 8 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms KCNS3 HGNC:6302 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 Q9BQ31 Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. Plasma membrane (GO:0005886) plasma membrane 100 6 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms KCNT1 HGNC:18865 potassium channel, subfamily T, member 1 Q5JUK3 Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 92 9 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNT2 HGNC:18866 potassium channel, subfamily T, member 2 Q6UVM3 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 14684870 plasma membrane 97 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KCNU1 HGNC:18867 potassium channel, subfamily U, member 1 A8MYU2 Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 61 8 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms KCNV1 HGNC:18861 potassium channel, subfamily V, member 1 Q6PIU1 Cell membrane; Multi-pass membrane protein. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9079713,9079713 plasma membrane 100 6 cytoplasm. plasma membrane multiple Tetrapoda Euteleostomi Cell.Organisms KCNV2 HGNC:19698 potassium channel, subfamily V, member 2 Q8TDN2 Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12060745,12060745 plasma membrane 100 6 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms KCP HGNC:17585 kielin/chordin-like protein Q6ZWJ8 Secreted (By similarity). secreted 74 0 secreted secreted Deuterostomia Eukaryota NA KCTD1 HGNC:18249 potassium channel tetramerization domain containing 1 Q719H9 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota KCTD10 HGNC:23236 potassium channel tetramerization domain containing 10 Q9H3F6 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota KCTD11 HGNC:21302 potassium channel tetramerization domain containing 11 Q693B1 Cytoplasm (GO:0005737) 15249678 endoplasmic reticulum 34 0 cytoplasm cytoplasm Theria Theria Eukaryota KCTD12 HGNC:14678 potassium channel tetramerization domain containing 12 Q96CX2 Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane (By similarity). endoplasmic reticulum 33 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Eumetazoa KCTD13 HGNC:22234 potassium channel tetramerization domain containing 13 Q8WZ19 Nucleus. Nucleus (GO:0005634) 11593007 nucleus 100 0 nucleus nucleus Theria Theria Eukaryota KCTD14 HGNC:23295 potassium channel tetramerization domain containing 14 Q9BQ13 nucleus 28 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota KCTD15 HGNC:23297 potassium channel tetramerization domain containing 15 Q96SI1 nucleus 75 0 nucleus nucleus Deuterostomia Bilateria Eukaryota KCTD16 HGNC:29244 potassium channel tetramerization domain containing 16 Q68DU8 Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane (By similarity). Plasma membrane (GO:0005886) endoplasmic reticulum 30 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota KCTD17 HGNC:25705 potassium channel tetramerization domain containing 17 Q8N5Z5 nucleus 24 0 nucleus nucleus Theria Euteleostomi Eukaryota KCTD18 HGNC:26446 potassium channel tetramerization domain containing 18 Q6PI47 nucleus 26 0 nucleus nucleus Theria Amniota Eukaryota KCTD19 HGNC:24753 potassium channel tetramerization domain containing 19 Q17RG1 nucleus 26 0 nucleus nucleus Amniota Amniota Eukaryota KCTD2 HGNC:21294 potassium channel tetramerization domain containing 2 Q14681 endoplasmic reticulum 24 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota KCTD20 HGNC:21052 potassium channel tetramerization domain containing 20 Q7Z5Y7 nucleus 71 0 nucleus nucleus Theria Chordata Eukaryota KCTD21 HGNC:27452 potassium channel tetramerization domain containing 21 Q4G0X4 nucleus 42 0 nucleus nucleus Amniota Eukaryota Eukaryota KCTD3 HGNC:21305 potassium channel tetramerization domain containing 3 Q9Y597 endoplasmic reticulum 28 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota KCTD4 HGNC:23227 potassium channel tetramerization domain containing 4 Q8WVF5 nucleus 27 0 nucleus nucleus Amniota Euteleostomi Eukaryota KCTD5 HGNC:21423 potassium channel tetramerization domain containing 5 Q9NXV2 Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins. endoplasmic reticulum 21 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota KCTD6 HGNC:22235 potassium channel tetramerization domain containing 6 Q8NC69 nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota KCTD7 HGNC:21957 potassium channel tetramerization domain containing 7 Q96MP8 Cell membrane. Cytoplasm, cytosol. nucleus 34 0 cytoplasm cytoplasm NA NA Eukaryota KCTD8 HGNC:22394 potassium channel tetramerization domain containing 8 Q6ZWB6 Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). nucleus 29 0 nucleus nucleus Chordata Chordata Eukaryota KCTD9 HGNC:22401 potassium channel tetramerization domain containing 9 Q7L273 nucleus 26 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms KDELC1 HGNC:19350 KDEL (Lys-Asp-Glu-Leu) containing 1 Q6UW63 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) 11167020 endoplasmic reticulum 90 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Eukaryota Eukaryota KDELC2 HGNC:28496 KDEL (Lys-Asp-Glu-Leu) containing 2 Q7Z4H8 Endoplasmic reticulum lumen (Potential). Extracellular (GO:0005576) endoplasmic reticulum 44 0 endoplasmic reticulum endoplasmic reticulum Eutheria Euteleostomi Cell.Organisms KDELR1 HGNC:6304 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 P24390 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 8392934,8392934 endoplasmic reticulum membrane 100 7 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Eukaryota Eukaryota Eukaryota KDELR2 HGNC:6305 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 P33947 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 1316805,1325562,1325562,1316805 endoplasmic reticulum membrane 100 7 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Eukaryota Eukaryota Eukaryota KDELR3 HGNC:6306 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 O43731 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eukaryota KDM1A HGNC:29079 lysine (K)-specific demethylase 1A O60341 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/16079794 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms KDM1B HGNC:21577 lysine (K)-specific demethylase 1B Q8NB78 Nucleus (By similarity). nucleus 88 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms KDM2A HGNC:13606 lysine (K)-specific demethylase 2A Q9Y2K7 Nucleus, nucleoplasm. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Cell.Organisms KDM2B HGNC:13610 lysine (K)-specific demethylase 2B Q8NHM5 Nucleus, nucleolus. Nucleus (GO:0005634) 15302935 nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta NA KDM3A HGNC:20815 lysine (K)-specific demethylase 3A Q9Y4C1 Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). nucleus 15 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota KDM3B HGNC:1337 lysine (K)-specific demethylase 3B Q7LBC6 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11687974,11687974,17081983,15635413 nucleus 19 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota KDM4A HGNC:22978 lysine (K)-specific demethylase 4A O75164 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota KDM4B HGNC:29136 lysine (K)-specific demethylase 4B O94953 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota KDM4C HGNC:17071 lysine (K)-specific demethylase 4C Q9H3R0 Nucleus (By similarity). Nucleus (GO:0005634) 10987278 nucleus 46 0 nucleus nucleus Bilateria Eukaryota Eukaryota KDM4D HGNC:25498 lysine (K)-specific demethylase 4D Q6B0I6 Nucleus (By similarity). Nucleus (GO:0005634) 17081983 nucleus 62 0 nucleus nucleus Eutheria Eutheria NA KDM4E HGNC:37098 lysine (K)-specific demethylase 4E B2RXH2 Nucleus (By similarity). nucleus 61 0 nucleus nucleus NA NA NA KDM5A HGNC:9886 lysine (K)-specific demethylase 5A P29375 Nucleus, nucleolus. Note=Occupies promoters of genes involved in RNA metabolism and mitochondrial function (By similarity). Nucleus (GO:0005634) 8414517,17081983 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota KDM5B HGNC:18039 lysine (K)-specific demethylase 5B Q9UGL1 Nucleus. Nucleus (GO:0005634) 10878660,10336460,17081983 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota KDM5C HGNC:11114 lysine (K)-specific demethylase 5C P41229 Nucleus. Nucleus (GO:0005634);Cytoplasm (GO:0005737) /17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota NA KDM5D HGNC:11115 lysine (K)-specific demethylase 5D Q9BY66 Nucleus (Probable). nucleus 83 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota KDM6A HGNC:12637 lysine (K)-specific demethylase 6A O15550 Nucleus (Probable). Nucleus (GO:0005634) 9499428 nucleus 20 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms KDM6B HGNC:29012 lysine (K)-specific demethylase 6B O15054 Nucleus (Probable). nucleus 23 0 nucleus nucleus Bilateria Eukaryota Eukaryota KDM7A HGNC:22224 lysine (K)-specific demethylase 7A Q6ZMT4 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Opisthokonta Eukaryota KDM8 HGNC:25840 lysine (K)-specific demethylase 8 Q8N371 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms KDR HGNC:6307 kinase insert domain receptor (a type III receptor tyrosine kinase) P35968 Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Isoform 2: Secreted (Probable). Isoform 3: Secreted. Plasma membrane (GO:0005886) 11166270 plasma membrane 35 1 cytoplasm. endosome. nucleus. plasma membrane. secreted multiple Deuterostomia Deuterostomia Cell.Organisms KDSR HGNC:4021 3-ketodihydrosphingosine reductase Q06136 Endoplasmic reticulum membrane; Multi-pass membrane protein. Extracellular (GO:0005576) 8417785 endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane. secreted multiple Eukaryota Cell.Organisms Cell.Organisms KEAP1 HGNC:23177 kelch-like ECH-associated protein 1 Q14145 Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus. Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 15379550,9887101,9887101 cytoplasm 23 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms KEL HGNC:6308 Kell blood group, metallo-endopeptidase P23276 Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton. Plasma membrane (GO:0005886) 11375401 plasma membrane 100 1 plasma membrane plasma membrane Theria Amniota NA KERA HGNC:6309 keratocan O60938 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10416788 secreted 89 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms KHDC1 HGNC:21366 KH homology domain containing 1 Q4VXA5 Membrane; Multi-pass membrane protein (Potential). cytoplasm 36 2 cytoplasm cytoplasm Euarchontoglires Euarchontoglires Euarchontoglires KHDC1L HGNC:37274 KH homology domain containing 1-like Q5JSQ8 cytoplasm 42 0 cytoplasm cytoplasm NA NA Euarchontoglires KHDC3L HGNC:33699 KH domain containing 3-like, subcortical maternal complex member Q587J8 cytoplasm 14 0 cytoplasm cytoplasm Eutheria Tetrapoda Eutheria KHDRBS1 HGNC:18116 KH domain containing, RNA binding, signal transduction associated 1 Q07666 Nucleus. Membrane. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 17081983/11932418,17081983,12112020,15635413 nucleus 53 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota KHDRBS2 HGNC:18114 KH domain containing, RNA binding, signal transduction associated 2 Q5VWX1 Nucleus (By similarity). Nucleus (GO:0005634) 12549823 nucleus 94 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota KHDRBS3 HGNC:18117 KH domain containing, RNA binding, signal transduction associated 3 O75525 Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one. Nucleus (GO:0005634) 10332027 nucleus 100 0 nucleus nucleus Human Bilateria Eukaryota KHK HGNC:6315 ketohexokinase (fructokinase) P50053 cytoplasm 54 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms KHNYN HGNC:20166 KH and NYN domain containing O15037 Nucleus (GO:0005634) 17081983 nucleus 41 0 nucleus nucleus Mammalia Euteleostomi Eukaryota KHSRP HGNC:6316 KH-type splicing regulatory protein Q92945 Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8940189,14657238,19059367,14657238 nucleus 13 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota KIAA0020 HGNC:29676 KIAA0020 Q15397 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) none,15561729,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota KIAA0040 HGNC:28950 KIAA0040 Q15053 secreted 46 2 n/a n/a NA NA Amniota KIAA0100 HGNC:28960 KIAA0100 Q14667 Secreted (Potential). mitochondrion 30 0 mitochondrion mitochondrion Bilateria Bilateria Eukaryota KIAA0101 HGNC:28961 KIAA0101 Q15004 Nucleus. Cytoplasm, perinuclear region. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region. nucleus 65 0 cytoplasm. nucleus multiple Chordata Chordata Opisthokonta KIAA0141 HGNC:28969 KIAA0141 Q14154 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Amniota Opisthokonta Cell.Organisms KIAA0195 HGNC:28983 KIAA0195 Q12767 Membrane; Multi-pass membrane protein (Potential). plasma membrane 94 10 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota KIAA0196 HGNC:28984 KIAA0196 Q12768 nucleus 69 1 nucleus nucleus Bilateria Eukaryota Eukaryota KIAA0226 HGNC:28991 KIAA0226 Q92622 Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endososome and not at all in the Golgi apparatus. nucleus 98 0 endosome. lysosome multiple Amniota Bilateria Eukaryota KIAA0226L HGNC:20420 KIAA0226-like Q9H714 nucleus 98 0 nucleus nucleus Amniota Eukaryota Eukaryota KIAA0232 HGNC:28992 KIAA0232 Q92628 Nucleus (GO:0005634) 17081983 nucleus 79 0 nucleus nucleus Chordata Chordata Bilateria KIAA0247 HGNC:19956 KIAA0247 Q92537 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 39 2 n/a n/a Euteleostomi Euteleostomi Craniata KIAA0319 HGNC:21580 KIAA0319 Q5VV43 Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted. Integral to membrane (GO:0016021) plasma membrane 6 1 endosome. plasma membrane multiple Deuterostomia Bilateria Cell.Organisms KIAA0319L HGNC:30071 KIAA0319-like Q8IZA0 Cytoplasmic granule membrane; Multi-pass membrane protein (Potential). secreted 76 2 n/a n/a Deuterostomia Bilateria Cell.Organisms KIAA0355 HGNC:29016 KIAA0355 O15063 secreted 29 0 secreted secreted Amniota Deuterostomia NA KIAA0368 HGNC:29020 KIAA0368 Q5VYK3 Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle. Centrosome (GO:0005813); Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023) 15496406,15496406,15496406,15496406 nucleus 87 0 cytoplasm. endoplasmic reticulum. endosome. nucleus multiple Opisthokonta Eukaryota Eukaryota KIAA0391 HGNC:19958 KIAA0391 O15091 Mitochondrion. Mitochondrion (GO:0005739) 15598749 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota KIAA0408 HGNC:21636 KIAA0408 Q6ZU52 nucleus 59 0 nucleus nucleus Homininae Amniota Euteleostomi KIAA0430 HGNC:29562 KIAA0430 Q9Y4F3 Peroxisome. Nucleus (GO:0005634) 17081983 peroxisome 100 0 nucleus. peroxisome multiple Deuterostomia Bilateria Eukaryota KIAA0513 HGNC:29058 KIAA0513 O60268 Cytoplasm (Probable). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 17010949,17010949 nucleus 65 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota KIAA0556 HGNC:29068 KIAA0556 O60303 nucleus 77 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota KIAA0586 HGNC:19960 KIAA0586 Q9BVV6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eumetazoa KIAA0753 HGNC:29110 KIAA0753 Q2KHM9 nucleus 72 0 nucleus nucleus Amniota Euteleostomi Eumetazoa KIAA0754 HGNC:29111 KIAA0754 O94854 secreted 22 0 secreted secreted NA NA Amniota KIAA0825 HGNC:28532 KIAA0825 Q8IV33 nucleus 83 2 nucleus nucleus Theria Euteleostomi Eumetazoa KIAA0895 HGNC:22206 KIAA0895 Q8NCT3 nucleus 68 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms KIAA0895L HGNC:34408 KIAA0895-like Q68EN5 nucleus 62 0 nucleus nucleus Chordata Eukaryota Eukaryota KIAA0907 HGNC:29145 KIAA0907 Q7Z7F0 secreted 19 0 secreted secreted Amniota Eukaryota Eukaryota KIAA0922 HGNC:29146 KIAA0922 A2VDJ0 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 30 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Eukaryota KIAA0930 HGNC:1314 KIAA0930 Q6ICG6 nucleus 26 0 nucleus nucleus Bilateria Eukaryota Eukaryota KIAA0947 HGNC:29154 KIAA0947 Q9Y2F5 secreted 20 0 secreted secreted Euteleostomi Euteleostomi Bilateria KIAA1024 HGNC:29172 KIAA1024 Q9UPX6 Membrane; Single-pass membrane protein (Potential). nucleus 77 1 nucleus nucleus Amniota Euteleostomi Craniata KIAA1024L HGNC:33914 KIAA1024-like P59773 Membrane; Single-pass membrane protein (Potential). plasma membrane 8 1 plasma membrane plasma membrane Human Human Euteleostomi KIAA1033 HGNC:29174 KIAA1033 Q2M389 nucleus 68 1 nucleus nucleus Bilateria Eukaryota Eukaryota KIAA1045 HGNC:29180 KIAA1045 Q9UPV7 cytoplasm 61 0 cytoplasm cytoplasm Amniota Euteleostomi Eumetazoa KIAA1107 HGNC:29192 KIAA1107 Q9UPP5 nucleus 10 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa KIAA1109 HGNC:26953 KIAA1109 Q2LD37 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) nucleus 31 2 nucleus nucleus Bilateria Bilateria Eukaryota KIAA1143 HGNC:29198 KIAA1143 Q96AT1 nucleus 92 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa KIAA1147 HGNC:29472 KIAA1147 A4D1U4 nucleus 30 0 nucleus nucleus NA NA NA KIAA1161 HGNC:19918 KIAA1161 Q6NSJ0 Membrane; Single-pass type II membrane protein (Potential). Nucleus (GO:0005634) 17081983 plasma membrane 9 1 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms KIAA1191 HGNC:29209 KIAA1191 Q96A73 Cytoplasm (By similarity). cytoplasm 76 0 cytoplasm cytoplasm Amniota Euteleostomi Craniata KIAA1210 HGNC:29218 KIAA1210 Q9ULL0 nucleus 91 0 nucleus nucleus NA NA Tetrapoda KIAA1211 HGNC:29219 KIAA1211 Q6ZU35 secreted 22 0 secreted secreted Euteleostomi Euteleostomi Craniata KIAA1211L HGNC:33454 KIAA1211-like Q6NV74 Nucleus (GO:0005634) 17081983 nucleus 19 0 nucleus nucleus Theria Theria Euteleostomi KIAA1217 HGNC:25428 KIAA1217 Q5T5P2 Cytoplasm (By similarity). cytoplasm 78 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa KIAA1244 HGNC:21213 KIAA1244 Q5TH69 Membrane; Single-pass membrane protein (Potential). nucleus 89 1 nucleus nucleus Bilateria Bilateria Eukaryota KIAA1257 HGNC:29231 KIAA1257 Q9ULG3 nucleus 65 0 nucleus nucleus Catarrhini Chordata Holozoa KIAA1279 HGNC:23419 KIAA1279 Q96EK5 Mitochondrion. cytoplasm 100 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota KIAA1324 HGNC:29618 KIAA1324 Q6UXG2 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 17 1 secreted secreted Deuterostomia Eukaryota Eukaryota KIAA1324L HGNC:21945 KIAA1324-like A8MWY0 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 23 1 secreted secreted Deuterostomia Eukaryota Eukaryota KIAA1328 HGNC:29248 KIAA1328 Q86T90 cytoplasm 14 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota KIAA1377 HGNC:29264 KIAA1377 Q9P2H0 nucleus 8 0 nucleus nucleus Mammalia Deuterostomia Olfactores KIAA1407 HGNC:29272 KIAA1407 Q8NCU4 nucleus 16 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa KIAA1429 HGNC:24500 KIAA1429 Q69YN4 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 14 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa KIAA1430 HGNC:29276 KIAA1430 Q9P2B7 nucleus 97 0 nucleus nucleus Amniota Chordata Holozoa KIAA1432 HGNC:17686 KIAA1432 Q4ADV7 Membrane; Single-pass membrane protein (Potential). nucleus 43 3 nucleus nucleus Opisthokonta Eukaryota Eukaryota KIAA1456 HGNC:26725 KIAA1456 Q8N9K7 secreted 91 0 secreted secreted NA NA Cell.Organisms KIAA1462 HGNC:29283 KIAA1462 Q9P266 Cell junction, adherens junction (By similarity). Note=Colocalizes with VE-Cadherin, in endothelial cells but not in epithelial cells (By similarity). secreted 46 0 secreted secreted Tetrapoda Euteleostomi Craniata KIAA1467 HGNC:29288 KIAA1467 A2RU67 Membrane; Single-pass membrane protein (Potential). plasma membrane 18 1 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa KIAA1468 HGNC:29289 KIAA1468 Q9P260 Cytoplasm (GO:0005737) 17081983 nucleus 93 1 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota KIAA1522 HGNC:29301 KIAA1522 Q9P206 cytoplasm 21 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Euteleostomi KIAA1524 HGNC:29302 KIAA1524 Q8TCG1 Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 12118381,12118381,,17632056, cytoplasm 19 1 cytoplasm. nucleus multiple Deuterostomia Bilateria Holozoa KIAA1549 HGNC:22219 KIAA1549 Q9HCM3 Membrane; Multi-pass membrane protein (Potential). plasma membrane 11 2 plasma membrane plasma membrane Theria Euteleostomi Bilateria KIAA1549L HGNC:24836 KIAA1549-like Q6ZVL6 Membrane; Single-pass membrane protein (Potential). secreted 5 1 secreted secreted Euteleostomi Euteleostomi Chordata KIAA1551 HGNC:25559 KIAA1551 Q9HCM1 nucleus 97 0 nucleus nucleus Mammalia Mammalia Amniota KIAA1586 HGNC:21360 KIAA1586 Q9HCI6 nucleus 87 0 nucleus nucleus Homininae Homininae Metazoa KIAA1598 HGNC:29319 KIAA1598 A0MZ66 Cell projection, axon (By similarity). nucleus 14 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa KIAA1614 HGNC:29327 KIAA1614 Q5VZ46 nucleus 89 0 nucleus nucleus Chordata Chordata Chordata KIAA1644 HGNC:29335 KIAA1644 Q3SXP7 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 29 1 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi KIAA1671 HGNC:29345 KIAA1671 Q9BY89 nucleus 89 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi KIAA1683 HGNC:29350 KIAA1683 Q9H0B3 Mitochondrion (GO:0005739) 11256614 cytoplasm 17 1 mitochondrion mitochondrion Eutheria Eutheria Eukaryota KIAA1715 HGNC:21610 KIAA1715 Q9C0E8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 19 2 n/a n/a Opisthokonta Eukaryota Eukaryota KIAA1731 HGNC:29366 KIAA1731 Q9C0D2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with centriolar acetylated tubulin. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa KIAA1751 HGNC:29368 KIAA1751 Q9C0B2 cytoplasm 12 1 cytoplasm cytoplasm NA NA NA KIAA1755 HGNC:29372 KIAA1755 Q5JYT7 cytoplasm 36 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa KIAA1841 HGNC:29387 KIAA1841 Q6NSI8 nucleus 80 0 nucleus nucleus Deuterostomia Bilateria Eukaryota KIAA1875 HGNC:26959 KIAA1875 A6NE52 cytoplasm 31 0 cytoplasm cytoplasm Mammalia Deuterostomia Cell.Organisms KIAA1919 HGNC:21053 KIAA1919 Q5TF39 Apical cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 12590146 plasma membrane 67 12 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms KIAA1958 HGNC:23427 KIAA1958 Q8N8K9 Nucleus (GO:0005634) 17081983 nucleus 5 0 nucleus nucleus Tetrapoda Tetrapoda Metazoa KIAA2013 HGNC:28513 KIAA2013 Q8IYS2 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 41 1 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa KIAA2018 HGNC:30494 KIAA2018 Q68DE3 Nucleus (Potential). nucleus 27 0 nucleus nucleus Amniota Euteleostomi Opisthokonta KIAA2022 HGNC:29433 KIAA2022 Q5QGS0 nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Craniata KIAA2026 HGNC:23378 KIAA2026 Q5HYC2 nucleus 11 0 nucleus nucleus Theria Tetrapoda Holozoa KIDINS220 HGNC:29508 kinase D-interacting substrate, 220kDa Q9ULH0 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10998417,11150334,14971036 nucleus 21 6 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms KIF11 HGNC:6388 kinesin family member 11 P52732 Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Microtubule (GO:0005874) 9235942,9235942,15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota KIF12 HGNC:21495 kinesin family member 12 Q96FN5 Cytoplasm, cytoskeleton (Probable). cytoplasm 21 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota KIF13A HGNC:14566 kinesin family member 13A Q9H1H9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane (By similarity). Note=Recruited to the midbody during cytokinesis. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 11106728,11106728 cytoplasm 30 0 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota KIF13B HGNC:14405 kinesin family member 13B Q9NQT8 Cytoplasm, cytoskeleton. Cell projection, axon. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites. Cytoplasm (GO:0005737) 10859302 cytoplasm 30 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota KIF14 HGNC:19181 kinesin family member 14 Q15058 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nuclear localization observed during interphase in PubMed:16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic in interphase (PubMed:16648480) and metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. Microtubule (GO:0005874); Nucleus (GO:0005634) 15561729,17081983 cytoplasm 27 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota KIF15 HGNC:17273 kinesin family member 15 Q9NS87 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). Centrosome (GO:0005813) 10878014 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota KIF16B HGNC:15869 kinesin family member 16B Q96L93 Cytoplasm, cytoskeleton (Probable). Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14. cytoplasm 33 0 cytoplasm cytoplasm Human Bilateria Eukaryota KIF17 HGNC:19167 kinesin family member 17 Q9P2E2 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cell projection (GO:0042995); Cytoskeleton (GO:0005856) 12493914,12493914,10846156,10846156 cytoplasm 28 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota KIF18A HGNC:29441 kinesin family member 18A Q8NI77 Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoskeleton (GO:0005856); Microtubule (GO:0005874) ,15561729 cytoplasm 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KIF18B HGNC:27102 kinesin family member 18B Q86Y91 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase. cytoplasm 25 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota KIF19 HGNC:26735 kinesin family member 19 Q2TAC6 Cytoplasm, cytoskeleton (By similarity). Cell projection, cilium (By similarity). Note=Localizes to cilia tips (By similarity). cytoplasm 25 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota KIF1A HGNC:888 kinesin family member 1A Q12756 Cytoplasm, cytoskeleton. Note=Expressed in distal regions of neurites. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota KIF1B HGNC:16636 kinesin family member 1B O60333 Cytoplasmic vesicle (By similarity). Cytoplasm, cytoskeleton (By similarity). Mitochondrion. Note=Colocalizes with synaptophysin at synaptic cytoplasmic transport vesicles in the neurites of hippocampal neurons (By similarity). Cytoplasmic vesicle (GO:0016023); Mitochondrion (GO:0005739); Microtubule (GO:0005874); Cytoplasm (GO:0005737) 12204119,7528108,15561729,17081983 cytoplasm 62 0 cytoplasm. mitochondrion multiple Bilateria Eukaryota Eukaryota KIF1C HGNC:6317 kinesin family member 1C O43896 Cytoplasm, cytoskeleton (Probable). Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 9685376,9685376,17081983 cytoplasm 70 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Bilateria Eukaryota Eukaryota KIF20A HGNC:9787 kinesin family member 20A O95235 Golgi apparatus (By similarity). Cytoplasm, cytoskeleton, spindle. Golgi apparatus (GO:0005794); Microtubule (GO:0005874); Nucleus (GO:0005634) 9438855,15561729,17081983 cytoplasm 19 0 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Eukaryota Eukaryota KIF20B HGNC:7212 kinesin family member 20B Q96Q89 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body. Nucleolus (GO:0005730); Nucleus (GO:0005634);Cytoplasm (GO:0005737) 11470801,12740395/11470801,12740395 cytoplasm 12 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota KIF21A HGNC:19349 kinesin family member 21A Q7Z4S6 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737);Nucleus (GO:0005634) 10225949/17081983 cytoplasm 23 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms KIF21B HGNC:29442 kinesin family member 21B O75037 Cytoplasm, cytoskeleton (By similarity). cytoplasm 22 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms KIF22 HGNC:6391 kinesin family member 22 Q14807 Nucleus. Cytoplasm, cytoskeleton (Probable). Nucleus (GO:0005634); Microtubule (GO:0005874) 11564754,15561729 cytoplasm 19 0 cytoplasm. nucleus multiple Mammalia Eukaryota Cell.Organisms KIF23 HGNC:6392 kinesin family member 23 Q02241 Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the interzone of mitotic spindles. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874);Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1406973,15075367,10403813,17081983,11877456,15561729/11877456,15075367/1406973,15075367,10403813,11877456 cytoplasm 16 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota KIF24 HGNC:19916 kinesin family member 24 Q5T7B8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole. Cytoskeleton (GO:0005856) cytoplasm 100 0 cytoplasm cytoplasm Human Tetrapoda Eukaryota KIF25 HGNC:6390 kinesin family member 25 Q9UIL4 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737) cytoplasm 23 0 cytoplasm cytoplasm Theria Deuterostomia Eukaryota KIF26A HGNC:20226 kinesin family member 26A Q9ULI4 Cytoplasm, cytoskeleton (Probable). cytoplasm 44 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota KIF26B HGNC:25484 kinesin family member 26B Q2KJY2 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (Probable). cytoplasm 86 2 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota KIF27 HGNC:18632 kinesin family member 27 Q86VH2 Cytoplasm, cytoskeleton (Probable). Cell projection, cilium (By similarity). Note=Localizes to centrioles and basal bodies (By similarity). cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota KIF2A HGNC:6318 kinesin heavy chain member 2A O00139 Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 9177777,17081983,none,17081983,15561729 cytoplasm 43 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KIF2B HGNC:29443 kinesin family member 2B Q8N4N8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient. cytoplasm 37 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KIF2C HGNC:6393 kinesin family member 2C Q99661 Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) 10600236,17081983,10600236,15635413,15561729 cytoplasm 43 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KIF3A HGNC:6319 kinesin family member 3A Q9Y496 Cytoplasm, cytoskeleton (Probable). Cell projection, cilium (By similarity). Cytoplasm (GO:0005737) 7559760 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota KIF3B HGNC:6320 kinesin family member 3B O15066 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9506951,9506951 cytoplasm 29 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota KIF3C HGNC:6321 kinesin family member 3C O14782 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 9450952,9450952,9487132 cytoplasm 31 0 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota KIF4A HGNC:13339 kinesin family member 4A O95239 Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 11736643,12809554,17081983,12809554,17081983,15561729,15598749 cytoplasm 28 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Eukaryota KIF4B HGNC:6322 kinesin family member 4B Q2VIQ3 Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (Probable). cytoplasm 28 0 cytoplasm cytoplasm NA NA Eukaryota KIF5A HGNC:6323 kinesin family member 5A Q12840 Cytoplasm, perinuclear region (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region (By similarity). Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 7514426,10964943,10491391,10964943,15561729 cytoplasm 98 0 cytoplasm. golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Eukaryota KIF5B HGNC:6324 kinesin family member 5B P33176 Cytoplasm, cytoskeleton (By similarity). Note=Uniformly distributed between soma and neurites in hippocampal neurons (By similarity). Mitochondrion (GO:0005739); Microtubule (GO:0005874) 9657148,15561729 cytoplasm 97 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota KIF5C HGNC:6325 kinesin family member 5C O60282 Cytoplasm, cytoskeleton (Probable). cytoplasm 70 0 cytoplasm cytoplasm Eukaryota Eukaryota NA KIF6 HGNC:21202 kinesin family member 6 Q6ZMV9 Cytoplasm, cytoskeleton (Probable). cytoplasm 25 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota KIF7 HGNC:30497 kinesin family member 7 Q2M1P5 Cell projection, cilium. Note=SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway. cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota KIF9 HGNC:16666 kinesin family member 9 Q9HAQ2 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737) 11483511 cytoplasm 25 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota KIFAP3 HGNC:17060 kinesin-associated protein 3 Q92845 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 8900189,9506951,9506951,8900189 cytoplasm 47 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Eukaryota KIFC1 HGNC:6389 kinesin family member C1 Q9BW19 Nucleus (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Early endosome (By similarity). Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis (By similarity). Microtubule (GO:0005874) 12939256 cytoplasm 30 0 cytoplasm cytoplasm Eukaryota Eukaryota NA KIFC2 HGNC:29530 kinesin family member C2 Q96AC6 Cytoplasm, cytoskeleton (Probable). Cell projection (GO:0042995); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9115737,9115737,9115737 cytoplasm 24 0 cytoplasm. nucleus multiple Theria Theria Eukaryota KIFC3 HGNC:6326 kinesin family member C3 Q9BVG8 Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell-cell contacts. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 12135985,12135985,12135985,15561729 cytoplasm 27 0 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Eukaryota NA KIN HGNC:6327 KIN, antigenic determinant of recA protein homolog (mouse) O60870 Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10964102,12754299,12359749,15635413 nucleus 27 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KIR2DL1 HGNC:6329 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 P43626 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7716543 plasma membrane 100 1 plasma membrane plasma membrane Human Human NA KIR2DL3 HGNC:6331 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 P43628 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 15227739 plasma membrane 100 1 plasma membrane plasma membrane NA NA NA KIR2DL4 HGNC:6332 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 Q99706 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 14500636,12055234,10190900 plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Eutheria NA KIR2DS4 HGNC:6336 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 P43632 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7749980,9521070 plasma membrane 100 1 plasma membrane plasma membrane NA NA NA KIR3DL1 HGNC:6338 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 P43629 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11207248 plasma membrane 100 1 plasma membrane plasma membrane Theria Theria NA KIR3DL2 HGNC:6339 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 P43630 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8617928 plasma membrane 100 1 plasma membrane plasma membrane NA NA NA KIR3DL3 HGNC:16312 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 Q8N743 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 0 plasma membrane plasma membrane NA NA NA KIRREL HGNC:15734 kin of IRRE like (Drosophila) Q96J84 Cell membrane; Single-pass type I membrane protein (Potential). Note=Predominantly located at podocyte slit diaphragm. Plasma membrane (GO:0005886) 12646566 plasma membrane 38 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms KIRREL2 HGNC:18816 kin of IRRE like 2 (Drosophila) Q6UWL6 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12837264,17081983 plasma membrane 27 1 nucleus. plasma membrane multiple Mammalia Mammalia Cell.Organisms KIRREL3 HGNC:23204 kin of IRRE like 3 (Drosophila) Q8IZU9 Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12424224,12424224,12424224 plasma membrane 100 1 cytoplasm. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms KISS1 HGNC:6341 KiSS-1 metastasis-suppressor Q15726 Secreted. Extracellular (GO:0005576) 12879005 secreted 100 0 secreted secreted Mammalia Mammalia Tetrapoda KISS1R HGNC:4510 KISS1 receptor Q969F8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11387329 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa KIT HGNC:6342 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog P10721 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. Plasma membrane (GO:0005886) 10582339 plasma membrane 93 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms KITLG HGNC:6343 KIT ligand P21583 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Soluble KIT ligand: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11999217,10901444,1378327,11999217,10901444,1378327 endoplasmic reticulum membrane 7 1 plasma membrane. secreted multiple Tetrapoda Euteleostomi Euteleostomi KIZ HGNC:15865 kizuna centrosomal protein Q2M2Z5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule- independent and dependent manner, respectively. Cytoplasm (GO:0005737) 17081983 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia NA KL HGNC:6344 klotho Q9UEF7 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Klotho peptide: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9464267,11162628,17086194,9464267 cytoplasm 32 1 plasma membrane. secreted multiple Bilateria Cell.Organisms Cell.Organisms KLB HGNC:15527 klotho beta Q86Z14 Cell membrane; Single-pass type III membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 26 1 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms KLC1 HGNC:6387 kinesin light chain 1 Q07866 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Cytosol (GO:0005829); Microtubule (GO:0005874); Axon (GO:0030424); Perinuclear vesicle (None); Cell junction (GO:0030054); Golgi apparatus (GO:0005794); Microsome (GO:0005792) 9624122,15987681,17081983,14985359,17332754,9624122,9624122,14985359,14985359,17332754,9624122 cytoplasm 17 0 cytoplasm. golgi apparatus multiple Bilateria Cell.Organisms Cell.Organisms KLC2 HGNC:20716 kinesin light chain 2 Q9H0B6 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Microsome (GO:0005792); Cytosol (GO:0005829); Perinuclear vesicle (None); Cell junction (GO:0030054); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 9624122,17081983,9624122,14985359,17332754,14985359,14985359,17332754,17081983 mitochondrion membrane 16 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Cell.Organisms Cell.Organisms KLC3 HGNC:20717 kinesin light chain 3 Q6P597 Cytoplasm, cytoskeleton (Probable). Note=Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria (By similarity). secreted 20 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms KLC4 HGNC:21624 kinesin light chain 4 Q9NSK0 Cytoplasm, cytoskeleton (Probable). cytoplasm 19 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms KLF1 HGNC:6345 Kruppel-like factor 1 (erythroid) Q13351 Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles (By similarity). Nucleus (GO:0005634) 12072445 nucleus 100 0 nucleus nucleus Theria Theria Eukaryota KLF10 HGNC:11810 Kruppel-like factor 10 Q13118 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9443078,10816551,9443078 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Chordata Eukaryota KLF11 HGNC:11811 Kruppel-like factor 11 O14901 Nucleus. Nucleus (GO:0005634) 9748269 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota KLF12 HGNC:6346 Kruppel-like factor 12 Q9Y4X4 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota KLF13 HGNC:13672 Kruppel-like factor 13 Q9Y2Y9 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17513757,12050170,17513757 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota KLF14 HGNC:23025 Kruppel-like factor 14 Q8TD94 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Eutheria Eutheria NA KLF15 HGNC:14536 Kruppel-like factor 15 Q9UIH9 Nucleus. Nucleus (GO:0005634) 10982849,11473619 nucleus 100 0 nucleus nucleus Chordata Chordata Eukaryota KLF16 HGNC:16857 Kruppel-like factor 16 Q9BXK1 Nucleus (By similarity). Nucleus (GO:0005634) 12036432 nucleus 76 0 nucleus nucleus Homininae Euarchontoglires Eukaryota KLF17 HGNC:18830 Kruppel-like factor 17 Q5JT82 Nucleus (Potential). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Eutheria Eutheria Eukaryota KLF2 HGNC:6347 Kruppel-like factor 2 Q9Y5W3 Nucleus (By similarity). Nucleus (GO:0005634) 16855590 nucleus 67 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota KLF3 HGNC:16516 Kruppel-like factor 3 (basic) P57682 Nucleus (Probable). Nucleus (GO:0005634) nucleus 74 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota KLF4 HGNC:6348 Kruppel-like factor 4 (gut) O43474 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15102675,8702718,15102675 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota KLF5 HGNC:6349 Kruppel-like factor 5 (intestinal) Q13887 Nucleus. Nucleus (GO:0005634) 10572182 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota KLF6 HGNC:2235 Kruppel-like factor 6 Q99612 Nucleus. Perinuclear region (GO:0048471); Nucleus (GO:0005634) 9689109,9689109 nucleus 100 0 cytoplasm. nucleus multiple Human Deuterostomia Eukaryota KLF7 HGNC:6350 Kruppel-like factor 7 (ubiquitous) O75840 Nucleus (Probable). Nucleus (GO:0005634) 9774444 nucleus 52 0 nucleus nucleus Euteleostomi Bilateria Eukaryota KLF8 HGNC:6351 Kruppel-like factor 8 O95600 Nucleus. Nucleus (GO:0005634) 12820964 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota KLF9 HGNC:1123 Kruppel-like factor 9 Q13886 Nucleus. Nucleus (GO:0005634) 8051167 nucleus 100 0 nucleus nucleus Mammalia Tetrapoda Eukaryota KLHDC1 HGNC:19836 kelch domain containing 1 Q8N7A1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Cell.Organisms KLHDC10 HGNC:22194 kelch domain containing 10 Q6PID8 cytoplasm 10 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms KLHDC2 HGNC:20231 kelch domain containing 2 Q9Y2U9 Nucleus. Nucleus (GO:0005634) 11384994 nucleus 100 0 nucleus nucleus Chordata Eukaryota Cell.Organisms KLHDC3 HGNC:20704 kelch domain containing 3 Q9BQ90 Cytoplasm. Note=Also found in meiotic chromatin (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12606021,12606021 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms KLHDC4 HGNC:25272 kelch domain containing 4 Q8TBB5 cytoplasm 9 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms KLHDC7A HGNC:26791 kelch domain containing 7A Q5VTJ3 Membrane; Single-pass membrane protein (Potential). cytoplasm 14 1 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms KLHDC7B HGNC:25145 kelch domain containing 7B Q96G42 cytoplasm 16 0 cytoplasm cytoplasm Human Mammalia Cell.Organisms KLHDC8A HGNC:25573 kelch domain containing 8A Q8IYD2 cytoplasm 34 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms KLHDC8B HGNC:28557 kelch domain containing 8B Q8IXV7 Cytoplasm. Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they are about to separate during cytokinesis. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Cell.Organisms KLHDC9 HGNC:28489 kelch domain containing 9 Q8NEP7 nucleus 18 0 nucleus nucleus Theria Tetrapoda Eukaryota KLHL1 HGNC:6352 kelch-like family member 1 Q9NR64 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 10888605 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms KLHL10 HGNC:18829 kelch-like family member 10 Q6JEL2 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 15136734 cytoplasm 98 0 cytoplasm cytoplasm Euteleostomi Bilateria NA KLHL11 HGNC:19008 kelch-like family member 11 Q9NVR0 nucleus 15 0 nucleus nucleus Mammalia Deuterostomia NA KLHL12 HGNC:19360 kelch-like family member 12 Q53G59 Cytoplasmic vesicle, COPII-coated vesicle. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms KLHL13 HGNC:22931 kelch-like family member 13 Q9P2N7 nucleus 20 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms KLHL14 HGNC:29266 kelch-like family member 14 Q9P2G3 Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Colocalizes with TOR1A at the endoplasmic reticulum level. nucleus 34 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms KLHL15 HGNC:29347 kelch-like family member 15 Q96M94 Nucleus (GO:0005634) nucleus 18 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KLHL17 HGNC:24023 kelch-like family member 17 Q6TDP4 Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density (By similarity). Cytoskeleton (GO:0005856) cytoplasm 37 0 cytoplasm cytoplasm Eutheria Bilateria Cell.Organisms KLHL18 HGNC:29120 kelch-like family member 18 O94889 cytoplasm 26 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms KLHL2 HGNC:6353 kelch-like family member 2 O95198 Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection (By similarity). Cell projection, lamellipodium (By similarity). Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over- expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). Cytoplasm (GO:0005737) cytoplasm 72 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms KLHL20 HGNC:25056 kelch-like family member 20 Q9Y2M5 Cytoplasm, perinuclear region. Nucleus. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination. Cytoskeleton (GO:0005856) 14668487 cytoplasm 33 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms KLHL21 HGNC:29041 kelch-like family member 21 Q9UJP4 Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms KLHL22 HGNC:25888 kelch-like family member 22 Q53GT1 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms KLHL23 HGNC:27506 kelch-like family member 23 Q8NBE8 cytoplasm 15 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms KLHL24 HGNC:25947 kelch-like family member 24 Q6TFL4 Perikaryon. Cell projection, axon (By similarity). Cytoplasm (By similarity). cytoplasm 19 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms KLHL25 HGNC:25732 kelch-like family member 25 Q9H0H3 nucleus 20 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms KLHL26 HGNC:25623 kelch-like family member 26 Q53HC5 nucleus 23 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms KLHL28 HGNC:19741 kelch-like family member 28 Q9NXS3 cytoplasm 25 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms KLHL29 HGNC:29404 kelch-like family member 29 Q96CT2 nucleus 21 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KLHL3 HGNC:6354 kelch-like family member 3 Q9UH77 Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm (GO:0005737) 10843806 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms KLHL30 HGNC:24770 kelch-like family member 30 Q0D2K2 cytoplasm 26 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms KLHL31 HGNC:21353 kelch-like family member 31 Q9H511 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 18719355,18719355 nucleus 16 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms KLHL32 HGNC:21221 kelch-like family member 32 Q96NJ5 nucleus 27 0 nucleus nucleus Human Euteleostomi Cell.Organisms KLHL33 HGNC:31952 kelch-like family member 33 A6NCF5 nucleus 14 0 nucleus nucleus Theria Euteleostomi Cell.Organisms KLHL34 HGNC:26634 kelch-like family member 34 Q8N239 nucleus 29 0 nucleus nucleus Theria Euteleostomi Cell.Organisms KLHL35 HGNC:26597 kelch-like family member 35 Q6PF15 cytoplasm 17 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms KLHL36 HGNC:17844 kelch-like family member 36 Q8N4N3 nucleus 22 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms KLHL38 HGNC:34435 kelch-like family member 38 Q2WGJ6 nucleus 16 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms KLHL4 HGNC:6355 kelch-like family member 4 Q9C0H6 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 10888605 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms KLHL40 HGNC:30372 kelch-like family member 40 Q2TBA0 nucleus 15 0 nucleus nucleus Chordata Chordata Cell.Organisms KLHL41 HGNC:16905 kelch-like family member 41 O60662 Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, pseudopodium. Cell projection, ruffle. Cytoplasm, myofibril, sarcomere, M line (By similarity). Note=Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10713668,10713668 nucleus 11 0 cytoplasm cytoplasm NA NA Cell.Organisms KLHL42 HGNC:29252 kelch-like family member 42 Q9P2K6 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis. cytoplasm 100 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms KLHL5 HGNC:6356 kelch-like family member 5 Q96PQ7 Cytoplasm, cytoskeleton. cytoplasm 100 2 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms KLHL6 HGNC:18653 kelch-like family member 6 Q8WZ60 nucleus 17 0 nucleus nucleus Chordata Chordata Cell.Organisms KLHL7 HGNC:15646 kelch-like family member 7 Q8IXQ5 Nucleus. nucleus 100 0 nucleus nucleus Human Euteleostomi Cell.Organisms KLHL8 HGNC:18644 kelch-like family member 8 Q9P2G9 secreted 26 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms KLHL9 HGNC:18732 kelch-like family member 9 Q9P2J3 nucleus 20 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms KLK1 HGNC:6357 kallikrein 1 P06870 Extracellular (GO:0005576) 12372819 secreted 51 0 secreted secreted Eutheria Bilateria Cell.Organisms KLK10 HGNC:6358 kallikrein-related peptidase 10 O43240 Secreted (Probable). Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12185203,12970725,14972646 secreted 33 0 cytoplasm. secreted multiple Catarrhini Mammalia Cell.Organisms KLK11 HGNC:6359 kallikrein-related peptidase 11 Q9UBX7 Isoform 1: Secreted. Isoform 2: Golgi apparatus. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11782391,11782391 secreted 73 0 cytoplasm. golgi apparatus. secreted multiple Theria Theria Cell.Organisms KLK12 HGNC:6360 kallikrein-related peptidase 12 Q9UKR0 Secreted. Extracellular (GO:0005576) 11056051 secreted 100 0 secreted secreted Human Eutheria Cell.Organisms KLK13 HGNC:6361 kallikrein-related peptidase 13 Q9UKR3 Secreted (Probable). Extracellular (GO:0005576) 10766816 secreted 38 0 secreted secreted Theria Theria Cell.Organisms KLK14 HGNC:6362 kallikrein-related peptidase 14 Q9P0G3 Secreted, extracellular space. Extracellular (GO:0005576) 11309303 secreted 100 0 secreted secreted Mammalia Mammalia Cell.Organisms KLK15 HGNC:20453 kallikrein-related peptidase 15 Q9H2R5 Secreted (Probable). Extracellular (GO:0005576) 11010966 secreted 38 0 secreted secreted Mammalia Cell.Organisms Cell.Organisms KLK2 HGNC:6363 kallikrein-related peptidase 2 P20151 Extracellular (GO:0005576) 10773882,11834722 secreted 71 0 secreted secreted Eutheria Bilateria Cell.Organisms KLK3 HGNC:6364 kallikrein-related peptidase 3 P07288 Secreted. Extracellular (GO:0005576) 11391681,11834722 secreted 100 0 secreted secreted Eutheria Bilateria Cell.Organisms KLK4 HGNC:6365 kallikrein-related peptidase 4 Q9Y5K2 Secreted. Nucleus (GO:0005634); Extracellular (GO:0005576) 11506707,10077646 secreted 100 0 nucleus. secreted multiple Eutheria Eutheria Cell.Organisms KLK5 HGNC:6366 kallikrein-related peptidase 5 Q9Y337 Secreted. Extracellular (GO:0005576) 10608802 secreted 100 0 secreted secreted Theria Theria Cell.Organisms KLK6 HGNC:6367 kallikrein-related peptidase 6 Q92876 Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress. Cytoplasm (GO:0005737) 11668196,12232761 secreted 35 0 cytoplasm. mitochondrion. nucleus. secreted multiple Human Eukaryota Cell.Organisms KLK7 HGNC:6368 kallikrein-related peptidase 7 P49862 Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Apical membrane (GO:0016327) 15297163,12738725,12738725,12738725 secreted 100 0 cytoplasm. secreted multiple Theria Theria Cell.Organisms KLK8 HGNC:6369 kallikrein-related peptidase 8 O60259 Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes. Extracellular (GO:0005576) 11309326 secreted 36 0 cytoplasm. secreted multiple Human Eutheria Cell.Organisms KLK9 HGNC:6370 kallikrein-related peptidase 9 Q9UKQ9 Secreted (Probable). Cytoplasm (GO:0005737) 11691797 secreted 44 0 cytoplasm. secreted multiple Theria Theria Cell.Organisms KLKB1 HGNC:6371 kallikrein B, plasma (Fletcher factor) 1 P03952 Secreted. Extracellular (GO:0005576) 16188874 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms KLLN HGNC:37212 killin, p53-regulated DNA replication inhibitor B2CW77 Nucleus. nucleus 100 0 nucleus nucleus NA NA NA KLRB1 HGNC:6373 killer cell lectin-like receptor subfamily B, member 1 Q12918 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 8077657 plasma membrane 15 1 plasma membrane plasma membrane Eutheria Mammalia Eumetazoa KLRC1 HGNC:6374 killer cell lectin-like receptor subfamily C, member 1 P26715 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 12444112,9034158 plasma membrane 17 1 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa KLRC2 HGNC:6375 killer cell lectin-like receptor subfamily C, member 2 P26717 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) plasma membrane 17 1 plasma membrane plasma membrane Catarrhini Catarrhini Eumetazoa KLRC3 HGNC:6376 killer cell lectin-like receptor subfamily C, member 3 Q07444 Membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) 9683661,10201920 plasma membrane 18 1 plasma membrane plasma membrane Homininae Homininae Eumetazoa KLRC4 HGNC:6377 killer cell lectin-like receptor subfamily C, member 4 O43908 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 10426993,10426994 plasma membrane 24 1 plasma membrane plasma membrane Homininae Homininae Amniota KLRD1 HGNC:6378 killer cell lectin-like receptor subfamily D, member 1 Q13241 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Soluble fraction (GO:0005625) 14607929,9886400 plasma membrane 22 1 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa KLRF1 HGNC:13342 killer cell lectin-like receptor subfamily F, member 1 Q9NZS2 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 11513955 plasma membrane 25 1 plasma membrane plasma membrane Catarrhini Mammalia Eumetazoa KLRF2 HGNC:37646 killer cell lectin-like receptor subfamily F, member 2 D3W0D1 Cell membrane; Single-pass type II membrane protein. plasma membrane 100 1 plasma membrane plasma membrane NA NA Eumetazoa KLRG1 HGNC:6380 killer cell lectin-like receptor subfamily G, member 1 Q96E93 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 1831652 plasma membrane 100 1 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa KLRG2 HGNC:24778 killer cell lectin-like receptor subfamily G, member 2 A4D1S0 Membrane; Single-pass membrane protein (Potential). nucleus 19 1 nucleus nucleus Theria Theria Euteleostomi KLRK1 HGNC:18788 killer cell lectin-like receptor subfamily K, member 1 P26718 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 12646700 plasma membrane 20 1 plasma membrane plasma membrane Mammalia Euteleostomi Holozoa KMO HGNC:6381 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) O15229 Mitochondrion outer membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9237672 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Bilateria Cell.Organisms Cell.Organisms KMT2A HGNC:7132 lysine (K)-specific methyltransferase 2A Q03164 Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus. Note=Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320. Nucleus (GO:0005634) 9129043,11313484,15199122,17081983 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia NA KMT2B HGNC:15840 lysine (K)-specific methyltransferase 2B Q9UMN6 Nucleus (By similarity). nucleus 28 0 nucleus nucleus NA NA Cell.Organisms KMT2C HGNC:13726 lysine (K)-specific methyltransferase 2C Q8NEZ4 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/17500065 nucleus 50 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms KMT2D HGNC:7133 lysine (K)-specific methyltransferase 2D O14686 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/9247308 nucleus 44 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms KMT2E HGNC:18541 lysine (K)-specific methyltransferase 2E Q8IZD2 Nucleus speckle. Note=Absent from the nucleolus. Nucleus (GO:0005634) 14718661 nucleus 100 0 nucleus nucleus Human Opisthokonta Cell.Organisms KNCN HGNC:26488 kinocilin A6PVL3 Membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634) 15855039 mitochondrion membrane 21 2 nucleus nucleus Homininae Eutheria Euarchontoglires KNDC1 HGNC:29374 kinase non-catalytic C-lobe domain (KIND) containing 1 Q76NI1 secreted 21 0 secreted secreted Deuterostomia Deuterostomia Eukaryota KNG1 HGNC:6383 kininogen 1 P01042 Secreted, extracellular space. Extracellular (GO:0005576) 8662705,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria KNOP1 HGNC:34404 lysine-rich nucleolar protein 1 Q1ED39 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634); Nucleus (GO:0005634) 15561729,17081983 nucleus 56 0 nucleus nucleus Theria Chordata Eumetazoa KNSTRN HGNC:30767 kinetochore-localized astrin/SPAG5 binding protein Q9Y448 Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends. cytoplasm 17 0 cytoplasm. nucleus multiple Theria Amniota Opisthokonta KNTC1 HGNC:17255 kinetochore associated 1 P50748 Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles. Kinetochore (GO:0000776); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15824131,15561729,11146660,11146660 nucleus 89 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota KPNA1 HGNC:6394 karyopherin alpha 1 (importin alpha 5) P52294 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11927559,11824786,11927559 cytoplasm 77 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KPNA2 HGNC:6395 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) P52292 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Centrosome (GO:0005813) 8617226,8617226,9275187,12883947,15635413,11790298,15561729 cytoplasm 52 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA KPNA3 HGNC:6396 karyopherin alpha 3 (importin alpha 4) O00505 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9435235,9435235,15635413 cytoplasm 36 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota KPNA4 HGNC:6397 karyopherin alpha 4 (importin alpha 3) O00629 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 10100610,9395085,15635413 cytoplasm 37 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota KPNA5 HGNC:6398 karyopherin alpha 5 (importin alpha 6) O15131 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9395085,9395085 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KPNA6 HGNC:6399 karyopherin alpha 6 (importin alpha 7) O60684 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813) 10523667,9275210,11751052,9275210,15561729 cytoplasm 99 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KPNA7 HGNC:21839 karyopherin alpha 7 (importin alpha 8) A9QM74 Nucleus. nucleus 100 0 nucleus nucleus Mammalia Mammalia Cell.Organisms KPNB1 HGNC:6400 karyopherin (importin) beta 1 Q14974 Cytoplasm. Nucleus envelope. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576); Mitochondrion (GO:0005739); Centrosome (GO:0005813) 7615630,8576188,7615630,14718574,15598749,15561729 cytoplasm 52 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota KPRP HGNC:31823 keratinocyte proline-rich protein Q5T749 Cytoplasm (By similarity). cytoplasm 60 0 cytoplasm cytoplasm Eutheria Eutheria Eutheria KPTN HGNC:6404 kaptin (actin binding protein) Q9Y664 Cytoplasm. Cytoplasm, perinuclear region. Cell projection, stereocilium. Cell projection, growth cone. Note=Perinuclear at the tips of stereocilium in the inner ear. Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones. Nucleus (GO:0005634) 1372044 cytoplasm 26 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota KRAS HGNC:6407 Kirsten rat sarcoma viral oncogene homolog P01116 Cell membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 10490827,11278702,12727204 cytoplasm 25 0 mitochondrion mitochondrion Euteleostomi Eukaryota Cell.Organisms KRBA1 HGNC:22228 KRAB-A domain containing 1 A5PL33 Nucleus (GO:0005634) nucleus 79 0 nucleus nucleus Eutheria Eutheria Eutheria KRBA2 HGNC:26989 KRAB-A domain containing 2 Q6ZNG9 Nucleus (GO:0005634) secreted 9 0 secreted secreted Catarrhini Eutheria Eukaryota KRBOX1 HGNC:38708 KRAB box domain containing 1 C9JBD0 nucleus 35 0 nucleus nucleus NA NA Tetrapoda KRBOX4 HGNC:26007 KRAB box domain containing 4 Q5JUW0 Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Catarrhini Eutheria Tetrapoda KRCC1 HGNC:28039 lysine-rich coiled-coil 1 Q9NPI7 nucleus 99 0 nucleus nucleus Eutheria Mammalia Euteleostomi KREMEN1 HGNC:17550 kringle containing transmembrane protein 1 Q96MU8 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 27 1 secreted secreted Euteleostomi Euteleostomi Eukaryota KREMEN2 HGNC:18797 kringle containing transmembrane protein 2 Q8NCW0 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12050670 secreted 28 1 plasma membrane plasma membrane Mammalia Tetrapoda Eukaryota KRI1 HGNC:25769 KRI1 homolog (S. cerevisiae) Q8N9T8 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 15 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota KRIT1 HGNC:1573 KRIT1, ankyrin repeat containing O00522 Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell junction. Note=KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Association with RAP1 relocalizes KRIT1 from microtubules to cell junction membranes. Translocates from the cytoplasm along microtubules to the cell membrane in a ITGB1BP1- dependent manner. Tubulin (GO:0045298); Cytoplasm (GO:0005737) 12140362,15046662,12140362 endoplasmic reticulum membrane 19 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms KRR1 HGNC:5176 KRR1, small subunit (SSU) processome component, homolog (yeast) Q13601 Cytoplasm. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV- 1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) 11790298,15635413,15561729,17081983 nucleus 54 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms KRT1 HGNC:6412 keratin 1 P04264 Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells. Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856) 9520414,15561729 cytoplasm 42 0 cytoplasm cytoplasm Euarchontoglires Euarchontoglires Metazoa KRT10 HGNC:6413 keratin 10 P13645 Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytoskeleton (GO:0005856) 2465278,12429849,15561729 cytoplasm 52 0 cytoplasm. nucleus multiple Mammalia Tetrapoda Metazoa KRT12 HGNC:6414 keratin 12 Q99456 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9399908,9171831 cytoplasm 49 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda NA KRT13 HGNC:6415 keratin 13 P13646 Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 17081983,17081983/10722565,10722565 cytoplasm 53 0 cytoplasm. nucleus multiple Amniota Amniota Metazoa KRT14 HGNC:6416 keratin 14 P02533 Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern. Cytoplasm (GO:0005737) 11973334 cytoplasm 72 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa KRT15 HGNC:6421 keratin 15 P19012 Cytoplasm (GO:0005737) 10623468 cytoplasm 58 0 cytoplasm cytoplasm Amniota Amniota Metazoa KRT16 HGNC:6423 keratin 16 P08779 Cytoplasm (GO:0005737) 8636216 cytoplasm 65 0 cytoplasm cytoplasm Theria Theria Metazoa KRT17 HGNC:6427 keratin 17 Q04695 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Extracellular (GO:0005576); Nucleus (GO:0005634) 7523421,12429849,16188874,17081983 cytoplasm 94 0 cytoplasm. nucleus. secreted multiple NA NA Metazoa KRT18 HGNC:6430 keratin 18 P05783 Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Extracellular (GO:0005576); Cytoskeleton (GO:0005856) 2454862,11955647,12429849,15822942,15561729 cytoplasm 35 0 cytoplasm. nucleus. secreted multiple Eutheria Euteleostomi Holozoa KRT19 HGNC:6436 keratin 19 P08727 Cytoplasm (GO:0005737) 2468493,16000376 cytoplasm 59 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa KRT2 HGNC:6439 keratin 2 P35908 Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 1380918,15561729 cytoplasm 44 0 cytoplasm cytoplasm Eutheria Eutheria Eumetazoa KRT20 HGNC:20412 keratin 20 P35900 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota NA KRT222 HGNC:28695 keratin 222 Q8N1A0 cytoplasm 19 0 cytoplasm cytoplasm Amniota Amniota Bilateria KRT23 HGNC:6438 keratin 23 (histone deacetylase inducible) Q9C075 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12015898,12015898 cytoplasm 27 0 cytoplasm. nucleus multiple Amniota Amniota NA KRT24 HGNC:18527 keratin 24 Q2M2I5 cytoplasm 49 0 cytoplasm cytoplasm Mammalia Tetrapoda Eumetazoa KRT25 HGNC:30839 keratin 25 Q7Z3Z0 Cytoplasm (By similarity). Cytoskeleton (GO:0005856) cytoplasm 90 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa KRT26 HGNC:30840 keratin 26 Q7Z3Y9 Cytoskeleton (GO:0005856) cytoplasm 64 0 cytoplasm cytoplasm Mammalia Mammalia Eumetazoa KRT27 HGNC:30841 keratin 27 Q7Z3Y8 Cytoplasm (By similarity). cytoplasm 86 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa KRT28 HGNC:30842 keratin 28 Q7Z3Y7 Cytoplasm (By similarity). cytoplasm 82 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa KRT3 HGNC:6440 keratin 3 P12035 Cytoplasm (GO:0005737) 9171831 cytoplasm 52 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa KRT31 HGNC:6448 keratin 31 Q15323 cytoplasm 40 0 cytoplasm cytoplasm Mammalia Mammalia NA KRT32 HGNC:6449 keratin 32 Q14532 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10391933,12543931 cytoplasm 37 0 cytoplasm. secreted multiple Mammalia Mammalia Cell.Organisms KRT33A HGNC:6450 keratin 33A O76009 Cytoplasm (GO:0005737) 10391933 cytoplasm 42 0 cytoplasm cytoplasm Mammalia Mammalia NA KRT33B HGNC:6451 keratin 33B Q14525 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10391933,14718574 cytoplasm 42 0 cytoplasm. secreted multiple Mammalia Mammalia NA KRT34 HGNC:6452 keratin 34 O76011 Cytoplasm (GO:0005737) 10391933 cytoplasm 40 0 cytoplasm cytoplasm Mammalia Mammalia Holozoa KRT35 HGNC:6453 keratin 35 Q92764 Cytoplasm (GO:0005737) 10391933 cytoplasm 39 0 cytoplasm cytoplasm Theria Eukaryota Eumetazoa KRT36 HGNC:6454 keratin 36 O76013 cytoplasm 48 0 cytoplasm cytoplasm Mammalia Mammalia Opisthokonta KRT37 HGNC:6455 keratin 37 O76014 Cytoplasm (GO:0005737) 10391933 cytoplasm 32 0 cytoplasm cytoplasm Mammalia Mammalia NA KRT38 HGNC:6456 keratin 38 O76015 Cytoplasm (GO:0005737) 10391933 cytoplasm 33 0 cytoplasm cytoplasm Mammalia Mammalia Eumetazoa KRT39 HGNC:32971 keratin 39 Q6A163 cytoplasm 39 0 cytoplasm cytoplasm Theria Theria NA KRT4 HGNC:6441 keratin 4 P19013 Cytoplasm (GO:0005737) 11132762 cytoplasm 47 0 cytoplasm cytoplasm Theria Eukaryota Metazoa KRT40 HGNC:26707 keratin 40 Q6A162 cytoplasm 34 0 cytoplasm cytoplasm Mammalia Mammalia NA KRT5 HGNC:6442 keratin 5 P13647 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1372711,2476664 cytoplasm 52 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota KRT6A HGNC:6443 keratin 6A P02538 Cytoplasm (GO:0005737) 7543104 cytoplasm 53 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa KRT6B HGNC:6444 keratin 6B P04259 Cytoplasm (GO:0005737) 1284199 cytoplasm 52 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa KRT6C HGNC:20406 keratin 6C P48668 Cytoskeleton (GO:0005856) 9054461 cytoplasm 53 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa KRT7 HGNC:6445 keratin 7 P08729 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9734130,18985008 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa KRT71 HGNC:28927 keratin 71 Q3SY84 Cytoskeleton (GO:0005856) 11982755,12648212 cytoplasm 49 0 cytoplasm cytoplasm Eutheria Mammalia Metazoa KRT72 HGNC:28932 keratin 72 Q14CN4 Cytoskeleton (GO:0005856) 11703281 cytoplasm 48 0 cytoplasm cytoplasm Eutheria Mammalia Metazoa KRT73 HGNC:28928 keratin 73 Q86Y46 cytoplasm 47 0 cytoplasm cytoplasm Eutheria Mammalia Metazoa KRT74 HGNC:28929 keratin 74 Q7RTS7 cytoplasm 44 0 cytoplasm cytoplasm Eutheria Mammalia Metazoa KRT75 HGNC:24431 keratin 75 O95678 cytoplasm 56 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa KRT76 HGNC:24430 keratin 76 Q01546 Cytoplasm (GO:0005737) cytoplasm 52 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa KRT77 HGNC:20411 keratin 77 Q7Z794 cytoplasm 43 0 cytoplasm cytoplasm Homininae Eutheria Metazoa KRT78 HGNC:28926 keratin 78 Q8N1N4 cytoplasm 38 0 cytoplasm cytoplasm Eutheria Eukaryota Eumetazoa KRT79 HGNC:28930 keratin 79 Q5XKE5 Cytoskeleton (GO:0005856) cytoplasm 48 0 cytoplasm cytoplasm Theria Theria Metazoa KRT8 HGNC:6446 keratin 8 P05787 Cytoplasm. Nucleus, nucleoplasm (By similarity). Nucleus matrix (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Extracellular (GO:0005576); Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 11781324,11790298,12429849,15822942,15561729,17081983 cytoplasm 55 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Opisthokonta KRT80 HGNC:27056 keratin 80 Q6KB66 cytoplasm 33 0 cytoplasm cytoplasm Eutheria Amniota Eumetazoa KRT81 HGNC:6458 keratin 81 Q14533 Cytoplasm (GO:0005737) 11792552 cytoplasm 41 0 cytoplasm cytoplasm Mammalia Mammalia Eumetazoa KRT82 HGNC:6459 keratin 82 Q9NSB4 cytoplasm 44 0 cytoplasm cytoplasm Eutheria Mammalia Metazoa KRT83 HGNC:6460 keratin 83 P78385 Cytoplasm (GO:0005737) cytoplasm 41 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa KRT84 HGNC:6461 keratin 84 Q9NSB2 cytoplasm 53 0 cytoplasm cytoplasm Euarchontoglires Eutheria Metazoa KRT85 HGNC:6462 keratin 85 P78386 Cytoplasm (GO:0005737) 10391933 cytoplasm 48 0 cytoplasm cytoplasm Mammalia Mammalia Holozoa KRT86 HGNC:6463 keratin 86 O43790 cytoplasm 38 0 cytoplasm cytoplasm NA NA Holozoa KRT9 HGNC:6447 keratin 9 P35527 Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 11774369,15561729 cytoplasm 34 0 cytoplasm cytoplasm Mammalia Mammalia Bilateria KRTAP1-1 HGNC:16772 keratin associated protein 1-1 Q07627 Cytoskeleton (GO:0005856) secreted 15 0 secreted secreted Euarchontoglires Mammalia NA KRTAP1-3 HGNC:16771 keratin associated protein 1-3 Q8IUG1 Cytoskeleton (GO:0005856) secreted 17 0 secreted secreted NA NA NA KRTAP1-4 HGNC:18904 keratin associated protein 1-4 P0C5Y4 secreted 99 0 secreted secreted NA NA NA KRTAP1-5 HGNC:16777 keratin associated protein 1-5 Q9BYS1 Cytoskeleton (GO:0005856) secreted 97 0 secreted secreted NA NA NA KRTAP10-1 HGNC:22966 keratin associated protein 10-1 P60331 secreted 97 0 secreted secreted Human Human NA KRTAP10-10 HGNC:22972 keratin associated protein 10-10 P60014 plasma membrane 15 0 n/a n/a NA NA NA KRTAP10-11 HGNC:20528 keratin associated protein 10-11 P60412 secreted 96 0 secreted secreted NA NA NA KRTAP10-12 HGNC:20533 keratin associated protein 10-12 P60413 secreted 98 0 secreted secreted Human Human NA KRTAP10-2 HGNC:22967 keratin associated protein 10-2 P60368 plasma membrane 13 0 n/a n/a Homininae Homininae NA KRTAP10-3 HGNC:22968 keratin associated protein 10-3 P60369 secreted 97 0 secreted secreted Human Mammalia NA KRTAP10-4 HGNC:20521 keratin associated protein 10-4 P60372 secreted 13 0 secreted secreted Eutheria Eutheria NA KRTAP10-5 HGNC:22969 keratin associated protein 10-5 P60370 secreted 97 0 secreted secreted NA NA NA KRTAP10-6 HGNC:20523 keratin associated protein 10-6 P60371 secreted 12 0 secreted secreted Eutheria Eutheria NA KRTAP10-7 HGNC:22970 keratin associated protein 10-7 P60409 secreted 10 0 secreted secreted Eutheria Eutheria Boreoeutheria KRTAP10-8 HGNC:20525 keratin associated protein 10-8 P60410 secreted 98 0 secreted secreted Eutheria Eutheria NA KRTAP10-9 HGNC:22971 keratin associated protein 10-9 P60411 plasma membrane 15 0 n/a n/a NA NA NA KRTAP11-1 HGNC:18922 keratin associated protein 11-1 Q8IUC1 secreted 99 0 secreted secreted Eutheria Mammalia Mammalia KRTAP12-1 HGNC:20529 keratin associated protein 12-1 P59990 secreted 99 0 secreted secreted Theria Theria NA KRTAP12-2 HGNC:20530 keratin associated protein 12-2 P59991 secreted 96 0 secreted secreted NA NA NA KRTAP12-3 HGNC:20531 keratin associated protein 12-3 P60328 secreted 99 0 secreted secreted Eutheria Eutheria NA KRTAP12-4 HGNC:20532 keratin associated protein 12-4 P60329 secreted 99 0 secreted secreted Human Catarrhini NA KRTAP13-1 HGNC:18924 keratin associated protein 13-1 Q8IUC0 secreted 100 0 secreted secreted Eutheria Mammalia Mammalia KRTAP13-2 HGNC:18923 keratin associated protein 13-2 Q52LG2 secreted 100 0 secreted secreted Catarrhini Catarrhini Mammalia KRTAP13-3 HGNC:18925 keratin associated protein 13-3 Q3SY46 secreted 100 0 secreted secreted NA NA Mammalia KRTAP13-4 HGNC:18926 keratin associated protein 13-4 Q3LI77 plasma membrane 19 0 n/a n/a Human Human Mammalia KRTAP15-1 HGNC:18927 keratin associated protein 15-1 Q3LI76 secreted 99 0 secreted secreted Homininae Euarchontoglires Eutheria KRTAP16-1 HGNC:18916 keratin associated protein 16-1 A8MUX0 secreted 11 0 secreted secreted Human Amniota NA KRTAP17-1 HGNC:18917 keratin associated protein 17-1 Q9BYP8 secreted 33 0 secreted secreted Homininae Homininae NA KRTAP19-1 HGNC:18936 keratin associated protein 19-1 Q8IUB9 Integral to membrane (GO:0016021) secreted 99 0 secreted secreted Human Human NA KRTAP19-2 HGNC:18937 keratin associated protein 19-2 Q3LHN2 secreted 98 0 secreted secreted Human Human NA KRTAP19-3 HGNC:18938 keratin associated protein 19-3 Q7Z4W3 Integral to membrane (GO:0016021) secreted 99 0 secreted secreted NA NA NA KRTAP19-4 HGNC:18939 keratin associated protein 19-4 Q3LI73 Integral to membrane (GO:0016021) secreted 96 0 secreted secreted Human Human Homo KRTAP19-5 HGNC:18940 keratin associated protein 19-5 Q3LI72 secreted 99 0 secreted secreted Human Human NA KRTAP19-6 HGNC:18941 keratin associated protein 19-6 Q3LI70 Integral to membrane (GO:0016021) secreted 99 0 secreted secreted Human Human NA KRTAP19-7 HGNC:18942 keratin associated protein 19-7 Q3SYF9 Integral to membrane (GO:0016021) secreted 99 0 secreted secreted NA NA NA KRTAP19-8 HGNC:33898 keratin associated protein 19-8 Q3LI54 Integral to membrane (GO:0016021) secreted 99 0 secreted secreted Homininae Homininae Primates KRTAP2-1 HGNC:16775 keratin associated protein 2-1 Q9BYU5 secreted 98 0 secreted secreted Theria Theria NA KRTAP2-2 HGNC:18905 keratin associated protein 2-2 Q9BYT5 secreted 98 0 secreted secreted Human Human Mammalia KRTAP2-3 HGNC:18906 keratin associated protein 2-3 P0C7H8 secreted 98 0 secreted secreted Human Human NA KRTAP2-4 HGNC:18891 keratin associated protein 2-4 Q9BYR9 secreted 98 0 secreted secreted Human Human NA KRTAP20-1 HGNC:18943 keratin associated protein 20-1 Q3LI63 Integral to membrane (GO:0016021) secreted 99 0 secreted secreted NA NA NA KRTAP20-2 HGNC:18944 keratin associated protein 20-2 Q3LI61 secreted 99 0 secreted secreted Human Human NA KRTAP20-3 HGNC:34001 keratin associated protein 20-3 Q3LI60 secreted 96 0 secreted secreted Homininae Homininae Homo KRTAP21-1 HGNC:18945 keratin associated protein 21-1 Q3LI58 secreted 93 0 secreted secreted Human Human NA KRTAP21-2 HGNC:18946 keratin associated protein 21-2 Q3LI59 secreted 96 0 secreted secreted Homininae Homininae NA KRTAP21-3 HGNC:34216 keratin associated protein 21-3 Q3LHN1 secreted 85 0 secreted secreted NA NA Homo KRTAP22-1 HGNC:18947 keratin associated protein 22-1 Q3MIV0 secreted 96 0 secreted secreted Catarrhini Catarrhini Homo KRTAP22-2 HGNC:37091 keratin associated protein 22-2 Q3LI68 secreted 87 0 secreted secreted Catarrhini Catarrhini Homo KRTAP23-1 HGNC:18928 keratin associated protein 23-1 A1A580 secreted 91 0 secreted secreted Homininae Homininae Homo KRTAP24-1 HGNC:33902 keratin associated protein 24-1 Q3LI83 secreted 99 0 secreted secreted Catarrhini Eutheria Eutheria KRTAP25-1 HGNC:34003 keratin associated protein 25-1 Q3LHN0 secreted 82 0 secreted secreted NA NA Mammalia KRTAP26-1 HGNC:33760 keratin associated protein 26-1 Q6PEX3 secreted 99 0 secreted secreted Homininae Mammalia Mammalia KRTAP27-1 HGNC:33864 keratin associated protein 27-1 Q3LI81 secreted 99 0 secreted secreted Human Eutheria Mammalia KRTAP29-1 HGNC:34211 keratin associated protein 29-1 A8MX34 plasma membrane 15 0 n/a n/a Human Euarchontoglires NA KRTAP3-1 HGNC:16778 keratin associated protein 3-1 Q9BYR8 Cytoskeleton (GO:0005856) secreted 99 0 secreted secreted Eutheria Mammalia NA KRTAP3-2 HGNC:16779 keratin associated protein 3-2 Q9BYR7 Cytoskeleton (GO:0005856) secreted 98 0 secreted secreted Homininae Homininae NA KRTAP3-3 HGNC:18890 keratin associated protein 3-3 Q9BYR6 Cytoskeleton (GO:0005856) secreted 99 0 secreted secreted Mammalia Mammalia NA KRTAP4-1 HGNC:18907 keratin associated protein 4-1 Q9BYQ7 Cytoskeleton (GO:0005856) secreted 97 0 secreted secreted Human Eutheria Eutheria KRTAP4-11 HGNC:18911 keratin associated protein 4-11 Q9BYQ6 Cytoskeleton (GO:0005856) secreted 12 0 secreted secreted NA NA NA KRTAP4-12 HGNC:16776 keratin associated protein 4-12 Q9BQ66 Cytoskeleton (GO:0005856) secreted 95 0 secreted secreted Human Human NA KRTAP4-2 HGNC:18900 keratin associated protein 4-2 Q9BYR5 Cytoskeleton (GO:0005856) secreted 17 0 secreted secreted NA NA Eutheria KRTAP4-3 HGNC:18908 keratin associated protein 4-3 Q9BYR4 secreted 95 0 secreted secreted Homininae Tetrapoda Homo KRTAP4-4 HGNC:16928 keratin associated protein 4-4 Q9BYR3 Cytoskeleton (GO:0005856) secreted 96 0 secreted secreted Theria Theria Boreoeutheria KRTAP4-5 HGNC:18899 keratin associated protein 4-5 Q9BYR2 Cytoskeleton (GO:0005856) secreted 95 0 secreted secreted Human Human Eutheria KRTAP4-6 HGNC:18909 keratin associated protein 4-6 Q9BYQ5 secreted 15 0 secreted secreted Theria Theria Eutheria KRTAP4-7 HGNC:18898 keratin associated protein 4-7 Q9BYR0 Cytoskeleton (GO:0005856) secreted 95 0 secreted secreted NA NA Eutheria KRTAP4-8 HGNC:17230 keratin associated protein 4-8 Q9BYQ9 secreted 96 0 secreted secreted NA NA Eutheria KRTAP4-9 HGNC:18910 keratin associated protein 4-9 Q9BYQ8 secreted 95 0 secreted secreted Human Catarrhini NA KRTAP5-1 HGNC:23596 keratin associated protein 5-1 Q6L8H4 secreted 17 0 secreted secreted Human Human NA KRTAP5-10 HGNC:23605 keratin associated protein 5-10 Q6L8G5 Cytoskeleton (GO:0005856) 15144888 secreted 14 0 secreted secreted Human Human NA KRTAP5-11 HGNC:23606 keratin associated protein 5-11 Q6L8G4 secreted 15 0 secreted secreted Human Human NA KRTAP5-2 HGNC:23597 keratin associated protein 5-2 Q701N4 nucleus 36 0 nucleus nucleus Human Human NA KRTAP5-3 HGNC:23598 keratin associated protein 5-3 Q6L8H2 Cytoskeleton (GO:0005856) 15144888 nucleus 20 0 nucleus nucleus Human Human NA KRTAP5-4 HGNC:23599 keratin associated protein 5-4 Q6L8H1 Cytoskeleton (GO:0005856) 15144888 nucleus 27 0 nucleus nucleus NA NA NA KRTAP5-5 HGNC:23601 keratin associated protein 5-5 Q701N2 nucleus 22 0 nucleus nucleus Human Human NA KRTAP5-6 HGNC:23600 keratin associated protein 5-6 Q6L8G9 nucleus 36 0 nucleus nucleus Human Human NA KRTAP5-7 HGNC:23602 keratin associated protein 5-7 Q6L8G8 nucleus 31 0 nucleus nucleus NA NA NA KRTAP5-8 HGNC:23603 keratin associated protein 5-8 O75690 nucleus 20 0 nucleus nucleus NA NA NA KRTAP5-9 HGNC:23604 keratin associated protein 5-9 P26371 secreted 19 0 secreted secreted NA NA NA KRTAP6-1 HGNC:18931 keratin associated protein 6-1 Q3LI64 secreted 99 0 secreted secreted Human Human NA KRTAP6-2 HGNC:18932 keratin associated protein 6-2 Q3LI66 secreted 98 0 secreted secreted Human Human NA KRTAP6-3 HGNC:18933 keratin associated protein 6-3 Q3LI67 secreted 99 0 secreted secreted Human Human NA KRTAP7-1 HGNC:18934 keratin associated protein 7-1 (gene/pseudogene) Q8IUC3 secreted 96 0 secreted secreted Human Eutheria NA KRTAP8-1 HGNC:18935 keratin associated protein 8-1 Q8IUC2 secreted 97 0 secreted secreted Eutheria Eutheria Mammalia KRTAP9-1 HGNC:18912 keratin associated protein 9-1 A8MXZ3 plasma membrane 15 0 n/a n/a NA NA NA KRTAP9-2 HGNC:16926 keratin associated protein 9-2 Q9BYQ4 Cytoskeleton (GO:0005856) secreted 19 0 secreted secreted NA NA NA KRTAP9-3 HGNC:16927 keratin associated protein 9-3 Q9BYQ3 Cytoskeleton (GO:0005856) plasma membrane 17 0 n/a n/a Human Human NA KRTAP9-4 HGNC:18902 keratin associated protein 9-4 Q9BYQ2 Cytoskeleton (GO:0005856) secreted 97 0 secreted secreted NA NA NA KRTAP9-6 HGNC:18914 keratin associated protein 9-6 A8MVA2 secreted 97 0 secreted secreted Human Human NA KRTAP9-7 HGNC:18915 keratin associated protein 9-7 A8MTY7 plasma membrane 17 0 n/a n/a Euarchontoglires Eutheria NA KRTAP9-8 HGNC:17231 keratin associated protein 9-8 Q9BYQ0 plasma membrane 19 0 n/a n/a Human Human Eutheria KRTAP9-9 HGNC:16773 keratin associated protein 9-9 Q9BYP9 secreted 15 0 secreted secreted Euarchontoglires Eutheria NA KRTCAP2 HGNC:28942 keratinocyte associated protein 2 Q8N6L1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 24 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Eukaryota Eukaryota KRTCAP3 HGNC:28943 keratinocyte associated protein 3 Q53RY4 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 61 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata KRTDAP HGNC:16313 keratinocyte differentiation-associated protein P60985 Secreted. secreted 100 0 secreted secreted Mammalia Mammalia Mammalia KSR1 HGNC:6465 kinase suppressor of ras 1 Q8IVT5 Cytoplasm. Membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery (By similarity). Plasma membrane (GO:0005886); Cell surface (GO:0009986); Cytoplasm (GO:0005737) 9115393,11741534,11741534,9115393 plasma membrane 10 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms KSR2 HGNC:18610 kinase suppressor of ras 2 Q6VAB6 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). plasma membrane 9 0 n/a n/a Euteleostomi Bilateria Cell.Organisms KTI12 HGNC:25160 KTI12 homolog, chromatin associated (S. cerevisiae) Q96EK9 nucleus 29 0 nucleus nucleus Euarchontoglires Eukaryota Eukaryota KTN1 HGNC:6467 kinectin 1 (kinesin receptor) Q86UP2 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764); Microtubule (GO:0005874) 17081983,17081983/7787243,12773547,11689693,15561729 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. lysosome. nucleus multiple Amniota Euteleostomi Bilateria KXD1 HGNC:28420 KxDL motif containing 1 Q9BQD3 nucleus 78 0 nucleus nucleus Bilateria Eukaryota Eukaryota KY HGNC:26576 kyphoscoliosis peptidase Q8NBH2 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). cytoplasm 87 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms KYNU HGNC:6469 kynureninase Q16719 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms L1CAM HGNC:6470 L1 cell adhesion molecule P32004 Cell membrane; Single-pass type I membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/11770884 plasma membrane 100 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria NA L1TD1 HGNC:25595 LINE-1 type transposase domain containing 1 Q5T7N2 cytoplasm 14 0 cytoplasm cytoplasm NA NA Eukaryota L2HGDH HGNC:20499 L-2-hydroxyglutarate dehydrogenase Q9H9P8 Mitochondrion. Mitochondrion (GO:0005739) 15385440 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms L3HYPDH HGNC:20488 L-3-hydroxyproline dehydratase (trans-) Q96EM0 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms L3MBTL1 HGNC:15905 l(3)mbt-like 1 (Drosophila) Q9Y468 Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex. Nucleoplasm (GO:0005654); Nucleus (GO:0005634) 10445843,17540172,17081983 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Holozoa L3MBTL2 HGNC:18594 l(3)mbt-like 2 (Drosophila) Q969R5 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11682070,11682070 nucleus 89 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa L3MBTL3 HGNC:23035 l(3)mbt-like 3 (Drosophila) Q96JM7 Nucleus (By similarity). Nucleus (GO:0005634) 15889154 nucleus 85 0 nucleus nucleus Deuterostomia Bilateria Holozoa L3MBTL4 HGNC:26677 l(3)mbt-like 4 (Drosophila) Q8NA19 Nucleus (Potential). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta LACC1 HGNC:26789 laccase (multicopper oxidoreductase) domain containing 1 Q8IV20 cytoplasm 39 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms LACE1 HGNC:16411 lactation elevated 1 Q8WV93 nucleus 17 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms LACRT HGNC:16430 lacritin Q9GZZ8 Secreted. Extracellular (GO:0005576) 11419941,16488965,15952718 secreted 100 0 secreted secreted Catarrhini Catarrhini Primates LACTB HGNC:16468 lactamase, beta P83111 Mitochondrion. Cytoplasm (GO:0005737);Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Ribosome (GO:0005840) 17081983/11551941,15598749,12164938,12164938,15561729 mitochondrion 100 1 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms LACTB2 HGNC:18512 lactamase, beta 2 Q53H82 mitochondrion 18 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms LACTBL1 HGNC:35445 lactamase, beta-like 1 A8MY62 mitochondrion 8 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms LAD1 HGNC:6472 ladinin 1 O00515 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Plasma membrane (GO:0005886) 9804354,9665393 nucleus 32 0 nucleus nucleus Mammalia Mammalia Eukaryota LAG3 HGNC:6476 lymphocyte-activation gene 3 P18627 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10545478 secreted 16 1 plasma membrane plasma membrane Amniota Amniota Deuterostomia LAGE3 HGNC:26058 L antigen family, member 3 Q14657 cytoplasm 35 0 cytoplasm cytoplasm Euarchontoglires Eukaryota Eukaryota LAIR1 HGNC:6477 leukocyte-associated immunoglobulin-like receptor 1 Q6GTX8 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9285412,10764762,10229813 plasma membrane 100 1 plasma membrane plasma membrane Eutheria Eutheria NA LAIR2 HGNC:6478 leukocyte-associated immunoglobulin-like receptor 2 Q6ISS4 Secreted. Extracellular (GO:0005576) 9285412 secreted 100 0 secreted secreted Catarrhini Catarrhini NA LALBA HGNC:6480 lactalbumin, alpha- P00709 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9136116,9925761,9925761,9925761 secreted 100 0 cytoplasm. nucleus. secreted multiple Theria Theria Bilateria LAMA1 HGNC:6481 laminin, alpha 1 P25391 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576); Nucleus (GO:0005634) 9334356,10837144,17081983 secreted 22 0 nucleus. secreted multiple Bilateria Cell.Organisms Eukaryota LAMA2 HGNC:6482 laminin, alpha 2 P24043 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11938437,9131649,10616210 secreted 24 0 cytoplasm. secreted multiple Bilateria Cell.Organisms Cell.Organisms LAMA3 HGNC:6483 laminin, alpha 3 Q16787 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576) 9151674 plasma membrane 23 0 secreted secreted Bilateria Eukaryota Cell.Organisms LAMA4 HGNC:6484 laminin, alpha 4 Q16363 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10934193,10934193 plasma membrane 18 0 secreted secreted Bilateria Eukaryota NA LAMA5 HGNC:6485 laminin, alpha 5 O15230 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11985661,11985661,11352943 secreted 21 0 cytoplasm. secreted multiple Bilateria Eukaryota Eukaryota LAMB1 HGNC:6486 laminin, beta 1 P07942 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576) 10407855 secreted 25 0 secreted secreted Bilateria Eukaryota Cell.Organisms LAMB2 HGNC:6487 laminin, beta 2 (laminin S) P55268 Secreted, extracellular space, extracellular matrix, basement membrane. Note=S-laminin is concentrated in the synaptic cleft of the neuromuscular junction. Extracellular (GO:0005576) 10454804 secreted 31 0 secreted secreted Bilateria Eukaryota Eukaryota LAMB3 HGNC:6490 laminin, beta 3 Q13751 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 11689492 secreted 17 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms LAMB4 HGNC:6491 laminin, beta 4 A4D0S4 Secreted, extracellular space, extracellular matrix, basement membrane. secreted 21 0 secreted secreted Bilateria Eukaryota Eukaryota LAMC1 HGNC:6492 laminin, gamma 1 (formerly LAMB2) P11047 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9755123,9755123 secreted 39 0 secreted secreted Bilateria Bilateria Cell.Organisms LAMC2 HGNC:6493 laminin, gamma 2 Q13753 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11920553,11279058,11920553 plasma membrane 23 0 cytoplasm. secreted multiple Bilateria Bilateria Cell.Organisms LAMC3 HGNC:6494 laminin, gamma 3 Q9Y6N6 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10225960,10225960 secreted 31 0 secreted secreted Bilateria Bilateria Eukaryota LAMP1 HGNC:6499 lysosomal-associated membrane protein 1 P11279 Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Co-localizes with OSBPL1A at the late endosome. Lysosome (GO:0005764); Plasma membrane (GO:0005886); Late endosome (GO:0005770); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 8647888,15708858,8647888,8647888,15708858,8647888,15598749 plasma membrane 74 1 endosome. endosome membrane. golgi apparatus. lysosome. lysosome membrane. mitochondrion. plasma membrane multiple Deuterostomia Bilateria Bilateria LAMP2 HGNC:6501 lysosomal-associated membrane protein 2 P13473 Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Endosome (GO:0005768); Lysosome (GO:0005764); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 8995204,9010755,9010755,8660832,9746610,8660832,7487911,9668075,15598749 plasma membrane 72 1 endoplasmic reticulum. endosome. endosome membrane. golgi apparatus. lysosome. lysosome membrane. mitochondrion. plasma membrane. secreted multiple Chordata Chordata Metazoa LAMP3 HGNC:14582 lysosomal-associated membrane protein 3 Q9UQV4 Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells. Lysosome (GO:0005764); Plasma membrane (GO:0005886) 9768752,9768752 secreted 29 1 lysosome. lysosome membrane. plasma membrane multiple Amniota Amniota Bilateria LAMP5 HGNC:16097 lysosomal-associated membrane protein family, member 5 Q9UJQ1 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle (By similarity). Cell projection, dendrite (By similarity). Cell projection, growth cone membrane; Single-pass type I membrane protein (By similarity). Early endosome membrane; Single-pass type I membrane protein (By similarity). Recycling endosome (By similarity). Note=Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum- Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes. plasma membrane 73 1 endosome membrane. plasma membrane multiple Tetrapoda Deuterostomia Bilateria LAMTOR1 HGNC:26068 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Q6IAA8 Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. nucleus 63 0 nucleus nucleus Mammalia Bilateria Opisthokonta LAMTOR2 HGNC:29796 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Q9Y2Q5 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Lysosome (GO:0005764) 11266467 secreted 58 0 lysosome lysosome Bilateria Bilateria Eukaryota LAMTOR3 HGNC:15606 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Q9UHA4 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Endosome (GO:0005768); Cytoplasm (GO:0005737) 12479806,12479806 cytoplasm 15 0 cytoplasm. endosome multiple Euteleostomi Eukaryota Eukaryota LAMTOR4 HGNC:33772 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Q0VGL1 Lysosome. cytoplasm 18 0 lysosome lysosome Mammalia Bilateria Holozoa LAMTOR5 HGNC:17955 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 O43504 Cytoplasm. Lysosome. Cytosol (GO:0005829); Nucleus (GO:0005634) 16176273,16176273 cytoplasm 83 0 cytoplasm. lysosome. nucleus multiple Tetrapoda Eukaryota Holozoa LANCL1 HGNC:6508 LanC lantibiotic synthetase component C-like 1 (bacterial) O43813 Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Detected at the surface of Maurer's clefts in malaria-infected erythrocytes at late stages of parasite development. Plasma membrane (GO:0005886) 10944443 mitochondrion membrane 23 2 cytoplasm. nucleus. plasma membrane multiple Euteleostomi Eukaryota Cell.Organisms LANCL2 HGNC:6509 LanC lantibiotic synthetase component C-like 2 (bacterial) Q9NS86 Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta- cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12566319,12566319,12566319 mitochondrion membrane 12 1 cytoplasm. nucleus. plasma membrane multiple Tetrapoda Eukaryota Cell.Organisms LANCL3 HGNC:24767 LanC lantibiotic synthetase component C-like 3 (bacterial) Q6ZV70 mitochondrion membrane 18 4 mitochondrion membrane mitochondrion membrane Deuterostomia Bilateria NA LAP3 HGNC:18449 leucine aminopeptidase 3 P28838 Cytoplasm. Cytoplasm (GO:0005737) 3733731 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms LAPTM4A HGNC:6924 lysosomal protein transmembrane 4 alpha Q15012 Endomembrane system; Multi-pass membrane protein (Potential). Note=May reside in an intracellular membrane- bound compartment (Potential). Golgi apparatus (GO:0005794) 8621662 plasma membrane 19 4 golgi apparatus golgi apparatus Deuterostomia Bilateria Eumetazoa LAPTM4B HGNC:13646 lysosomal protein transmembrane 4 beta Q86VI4 Endomembrane system; Multi-pass membrane protein. Lysosome (GO:0005764); Integral to membrane (GO:0016021); Endosome (GO:0005768) 12902989,15911104,12947545,12902989,12902989,15911104 plasma membrane 13 4 endomembrane system. endosome. lysosome multiple Amniota Euteleostomi Eumetazoa LAPTM5 HGNC:29612 lysosomal protein transmembrane 5 Q13571 Lysosome membrane; Multi-pass membrane protein. Lysosome (GO:0005764) 8661146 endoplasmic reticulum membrane 25 5 lysosome. lysosome membrane multiple Tetrapoda Tetrapoda Eumetazoa LARGE HGNC:6511 like-glycosyltransferase O95461 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 15210115 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Deuterostomia Eukaryota Cell.Organisms LARP1 HGNC:29531 La ribonucleoprotein domain family, member 1 Q6PKG0 Nucleus (GO:0005634); Nucleolus (GO:0005730);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15302935,15060081,15060081/17081983,17081983 cytoplasm 48 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota LARP1B HGNC:24704 La ribonucleoprotein domain family, member 1B Q659C4 cytoplasm 43 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota LARP4 HGNC:24320 La ribonucleoprotein domain family, member 4 Q71RC2 Nucleus (GO:0005634); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15561729,17081983,17081983 cytoplasm 29 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Eukaryota LARP4B HGNC:28987 La ribonucleoprotein domain family, member 4B Q92615 Cytoplasm, cytosol. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs in response to arsenite treatment. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota LARP6 HGNC:24012 La ribonucleoprotein domain family, member 6 Q9BRS8 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. cytoplasm 22 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota LARP7 HGNC:24912 La ribonucleoprotein domain family, member 7 Q4G0J3 Nucleus, nucleoplasm. nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms LARS HGNC:6512 leucyl-tRNA synthetase Q9P2J5 Cytoplasm (By similarity). Mitochondrion (GO:0005739); Cytosol (GO:0005829) 12821328,15598749,15561729 cytoplasm 38 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms LARS2 HGNC:17095 leucyl-tRNA synthetase 2, mitochondrial Q15031 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 10647888 mitochondrion 29 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms LAS1L HGNC:25726 LAS1-like (S. cerevisiae) Q9Y4W2 Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 77 0 nucleus nucleus Amniota Eukaryota Eukaryota LASP1 HGNC:6513 LIM and SH3 protein 1 Q14847 Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the F-actin rich cortical cytoskeleton (By similarity). Cytosol (GO:0005829); Cytoskeleton (GO:0005856); Focal adhesion (GO:0005925) 12571245,9848085,15004028 cytoplasm 36 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota LAT HGNC:18874 linker for activation of T cells O43561 Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Plasma membrane (GO:0005886); Endosome (GO:0005768) 9489702,11756537,14996932,12077228,11752630,14996932 plasma membrane 100 0 endosome. plasma membrane multiple Theria Theria Mammalia LAT2 HGNC:12749 linker for activation of T cells family, member 2 Q9GZY6 Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Membrane fraction (GO:0005624) 12514734 plasma membrane 100 0 plasma membrane plasma membrane Euarchontoglires Amniota NA LATS1 HGNC:6514 large tumor suppressor kinase 1 O95835 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 10831611,10831611 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms LATS2 HGNC:6515 large tumor suppressor kinase 2 Q9NRM7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Co-localizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment. Cytoplasm (GO:0005737); Centrosome (GO:0005813) 16413547,16413547 cytoplasm 54 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms LAX1 HGNC:26005 lymphocyte transmembrane adaptor 1 Q8IWV1 Cell membrane; Single-pass type III membrane protein. Integral to membrane (GO:0016021) 12359715 plasma membrane 100 1 plasma membrane plasma membrane Mammalia Mammalia Mammalia LAYN HGNC:29471 layilin Q6UX15 Membrane; Single-pass type I membrane protein (Potential). Note=Colocalizes with TLN1 at the membrane ruffles (By similarity). Plasma membrane (GO:0005886) 9786953 secreted 22 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms LBH HGNC:29532 limb bud and heart development Q53QV2 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11336496,11336496,17081983 secreted 28 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata LBP HGNC:6517 lipopolysaccharide binding protein P18428 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12831460,11598069,12831460,11598069 secreted 100 0 secreted secreted Deuterostomia Eukaryota Eukaryota LBR HGNC:6518 lamin B receptor Q14739 Nucleus inner membrane; Multi-pass membrane protein. Nuclear membrane (GO:0005635); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8157662,14701833,9003786,15598749,17081983,17081983 nucleus membrane 100 10 cytoplasm. mitochondrion. nucleus. nucleus membrane multiple Eukaryota Eukaryota Cell.Organisms LBX1 HGNC:16960 ladybird homeobox 1 P52954 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Amniota Bilateria Eukaryota LBX2 HGNC:15525 ladybird homeobox 2 Q6XYB7 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus Theria Theria Eukaryota LCA5 HGNC:31923 Leber congenital amaurosis 5 Q86VQ0 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In non- ciliated cells, localizes to the centrosome and its associated microtubule array. cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Holozoa LCA5L HGNC:1255 Leber congenital amaurosis 5-like O95447 cytoplasm 22 0 cytoplasm cytoplasm Amniota Amniota Opisthokonta LCAT HGNC:6522 lecithin-cholesterol acyltransferase P04180 Secreted. Note=Secreted into blood plasma. Produced in astrocytes and secreted into cerebral spinal fluid (CSF). Extracellular (GO:0005576) 1468226 secreted 100 1 secreted secreted Theria Euteleostomi Cell.Organisms LCE1A HGNC:29459 late cornified envelope 1A Q5T7P2 secreted 99 0 secreted secreted Human Human NA LCE1B HGNC:16611 late cornified envelope 1B Q5T7P3 plasma membrane 18 0 n/a n/a Human Human NA LCE1C HGNC:29464 late cornified envelope 1C Q5T751 plasma membrane 20 0 n/a n/a Human Human NA LCE1D HGNC:29465 late cornified envelope 1D Q5T752 plasma membrane 20 0 n/a n/a Human Human NA LCE1E HGNC:29466 late cornified envelope 1E Q5T753 plasma membrane 22 0 n/a n/a Human Human NA LCE1F HGNC:29467 late cornified envelope 1F Q5T754 plasma membrane 18 0 n/a n/a NA NA NA LCE2A HGNC:29469 late cornified envelope 2A Q5TA79 secreted 94 0 secreted secreted Human Human NA LCE2B HGNC:16610 late cornified envelope 2B O14633 secreted 95 0 secreted secreted Human Human NA LCE2C HGNC:29460 late cornified envelope 2C Q5TA81 secreted 95 0 secreted secreted Human Human NA LCE2D HGNC:16518 late cornified envelope 2D Q5TA82 secreted 98 0 secreted secreted Human Human NA LCE3A HGNC:29461 late cornified envelope 3A Q5TA76 secreted 84 0 secreted secreted Human Human NA LCE3B HGNC:29462 late cornified envelope 3B Q5TA77 secreted 95 0 secreted secreted Catarrhini Catarrhini Homo LCE3C HGNC:16612 late cornified envelope 3C Q5T5A8 secreted 82 0 secreted secreted NA NA Primates LCE3D HGNC:16615 late cornified envelope 3D Q9BYE3 secreted 82 0 secreted secreted Human Human NA LCE3E HGNC:29463 late cornified envelope 3E Q5T5B0 secreted 91 0 secreted secreted Homininae Homininae NA LCE4A HGNC:16613 late cornified envelope 4A Q5TA78 secreted 97 0 secreted secreted Human Human NA LCE5A HGNC:16614 late cornified envelope 5A Q5TCM9 secreted 97 0 secreted secreted Human Human NA LCE6A HGNC:31824 late cornified envelope 6A A0A183 secreted 55 0 secreted secreted NA NA Homo LCK HGNC:6524 lymphocyte-specific protein tyrosine kinase P06239 Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Present in lipid rafts in an inactive form. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7513706,7513706,16888650 cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms LCLAT1 HGNC:26756 lysocardiolipin acyltransferase 1 Q6UWP7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Microsome (GO:0005792); Endoplasmic reticulum (GO:0005783) 15152008,15152008,15152008 endoplasmic reticulum membrane 100 6 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Opisthokonta Eukaryota Cell.Organisms LCMT1 HGNC:17557 leucine carboxyl methyltransferase 1 Q9UIC8 nucleus 51 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota LCMT2 HGNC:17558 leucine carboxyl methyltransferase 2 O60294 cytoplasm 12 0 cytoplasm cytoplasm Euarchontoglires Eukaryota Eukaryota LCN1 HGNC:6525 lipocalin 1 P31025 Secreted. Extracellular (GO:0005576) 8276406 secreted 100 0 secreted secreted Mammalia Mammalia Euteleostomi LCN10 HGNC:20892 lipocalin 10 Q6JVE6 Secreted (Potential). secreted 9 0 secreted secreted Theria Theria Euteleostomi LCN12 HGNC:28733 lipocalin 12 Q6JVE5 Secreted (Potential). secreted 17 0 secreted secreted Eutheria Eutheria Euteleostomi LCN15 HGNC:33777 lipocalin 15 Q6UWW0 Secreted (Potential). secreted 18 0 secreted secreted Amniota Amniota Euteleostomi LCN2 HGNC:6526 lipocalin 2 P80188 Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. Secretory granule (GO:0030141); Extracellular (GO:0005576) 9339356,7997842,8195592,10339412,11486081 secreted 100 0 secreted secreted Theria Theria Euteleostomi LCN6 HGNC:17337 lipocalin 6 P62502 Secreted. Note=Located on the head and tail of spermatozoa with the highest concentration on the post- acrosomal region of the head, where it appears aggregated into large patches. Extracellular (GO:0005576) 15363845 secreted 100 0 secreted secreted Eutheria Eutheria NA LCN8 HGNC:27038 lipocalin 8 Q6JVE9 Secreted (By similarity). secreted 15 0 secreted secreted Eutheria Eutheria Mammalia LCN9 HGNC:17442 lipocalin 9 Q8WX39 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Eutheria Amniota LCNL1 HGNC:34436 lipocalin-like 1 Q6ZST4 secreted 14 0 secreted secreted Amniota Amniota Euteleostomi LCOR HGNC:29503 ligand dependent nuclear receptor corepressor Q96JN0 Nucleus. Nucleus (GO:0005634) 12535528 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria LCORL HGNC:30776 ligand dependent nuclear receptor corepressor-like Q8N3X6 Nucleus (By similarity). Nucleus (GO:0005634) 12560079 nucleus 40 0 nucleus nucleus Amniota Euteleostomi Bilateria LCP1 HGNC:6528 lymphocyte cytosolic protein 1 (L-plastin) P13796 Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11279160,15598749 cytoplasm 75 0 cytoplasm. mitochondrion multiple Opisthokonta Eukaryota Eukaryota LCP2 HGNC:6529 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) Q13094 Cytoplasm (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 7706237,10993915 nucleus 21 0 cytoplasm cytoplasm Amniota Euteleostomi Holozoa LCT HGNC:6530 lactase P09848 Apical cell membrane; Single-pass type I membrane protein. Note=Brush border. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 7523415,7523415,7523415 plasma membrane 100 1 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms LCTL HGNC:15583 lactase-like Q6UWM7 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 12084582 plasma membrane 34 0 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms LDB1 HGNC:6532 LIM domain binding 1 Q86U70 Nucleus (Probable). Nucleus (GO:0005634) ,9391090,19117995, nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota LDB2 HGNC:6533 LIM domain binding 2 O43679 Nucleus. Nucleus (GO:0005634) 10083735,10431247 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota LDB3 HGNC:15710 LIM domain binding 3 O75112 Cytoplasm, perinuclear region. Cell projection, pseudopodium. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines. Cytoplasm (GO:0005737) 10427098 cytoplasm 38 0 cytoplasm cytoplasm Chordata Chordata Eukaryota LDHA HGNC:6535 lactate dehydrogenase A P00338 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829) 2434947,15635413,16263121 cytoplasm 100 1 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms LDHAL6A HGNC:28335 lactate dehydrogenase A-like 6A Q6ZMR3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms LDHAL6B HGNC:21481 lactate dehydrogenase A-like 6B Q9BYZ2 cytoplasm 78 0 cytoplasm cytoplasm Euarchontoglires Euarchontoglires Cell.Organisms LDHB HGNC:6541 lactate dehydrogenase B P07195 Cytoplasm. Cytoplasm (GO:0005737) 1371976 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms LDHC HGNC:6544 lactate dehydrogenase C P07864 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 11377399,7382246,11377399,11377399 cytoplasm 100 0 cytoplasm. mitochondrion multiple Homininae Eutheria Cell.Organisms LDHD HGNC:19708 lactate dehydrogenase D Q86WU2 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12127981 mitochondrion 82 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms LDLR HGNC:6547 low density lipoprotein receptor P01130 Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endosome (GO:0005768) 226968,6129958,12459547 plasma membrane 23 0 endomembrane system. endosome. golgi apparatus. lysosome. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms LDLRAD1 HGNC:32069 low density lipoprotein receptor class A domain containing 1 Q5T700 Membrane; Single-pass membrane protein (Potential). secreted 23 1 secreted secreted Theria Amniota Eumetazoa LDLRAD2 HGNC:32071 low density lipoprotein receptor class A domain containing 2 Q5SZI1 Membrane; Single-pass type I membrane protein. secreted 98 0 secreted secreted Theria Theria Bilateria LDLRAD3 HGNC:27046 low density lipoprotein receptor class A domain containing 3 Q86YD5 Cell membrane; Single-pass type I membrane protein (By similarity). plasma membrane 95 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Opisthokonta LDLRAD4 HGNC:1224 low density lipoprotein receptor class A domain containing 4 O15165 Cell membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 52 1 secreted secreted Euteleostomi Euteleostomi Bilateria LDLRAP1 HGNC:18640 low density lipoprotein receptor adaptor protein 1 Q5SW96 Cytoplasm. Plasma membrane (GO:0005886); Endosome (GO:0005768) 12451172,14528014 cytoplasm 100 0 cytoplasm. endosome multiple Euteleostomi Bilateria Holozoa LDOC1 HGNC:6548 leucine zipper, down-regulated in cancer 1 O95751 Nucleus. Nucleus (GO:0005634) 10403563 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria NA LDOC1L HGNC:13343 leucine zipper, down-regulated in cancer 1-like Q6ICC9 nucleus 27 0 nucleus nucleus Eutheria Eutheria Opisthokonta LEAP2 HGNC:29571 liver expressed antimicrobial peptide 2 Q969E1 Secreted. Extracellular (GO:0005576) 12493837 secreted 100 0 secreted secreted Amniota Amniota Euteleostomi LECT1 HGNC:17005 leukocyte cell derived chemotaxin 1 O75829 Chondromodulin-1: Secreted. Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein (Potential). Cytoplasm (GO:0005737); Extracellular matrix (GO:0005578) 10103018,14744535,10103018,14744535 secreted 12 1 cytoplasm. secreted multiple Euteleostomi Euteleostomi Bilateria LECT2 HGNC:6550 leukocyte cell-derived chemotaxin 2 O14960 Cytoplasm. Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9266841,8877413,9266841,9832057 secreted 83 0 cytoplasm. secreted multiple Amniota Euteleostomi Eumetazoa LEF1 HGNC:6551 lymphoid enhancer-binding factor 1 Q9UJU2 Nucleus (By similarity). Note=Found in nuclear bodies upon PIASG binding (By similarity). Nucleus (GO:0005634) 9671491,1827423,10756202 nucleus 97 0 nucleus nucleus Euteleostomi Bilateria Eukaryota LEFTY1 HGNC:6552 left-right determination factor 1 O75610 Secreted. secreted 100 0 secreted secreted NA NA Eumetazoa LEFTY2 HGNC:3122 left-right determination factor 2 O00292 Secreted. Extracellular (GO:0005576) 9496783 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Eumetazoa LEKR1 HGNC:33765 leucine, glutamate and lysine rich 1 Q6ZMV7 nucleus 16 0 nucleus nucleus NA NA Eumetazoa LELP1 HGNC:32046 late cornified envelope-like proline-rich 1 Q5T871 secreted 98 0 secreted secreted Catarrhini Eutheria Eutheria LEMD1 HGNC:18725 LEM domain containing 1 Q68G75 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) nucleus membrane 39 1 nucleus membrane nucleus membrane Theria Chordata Bilateria LEMD2 HGNC:21244 LEM domain containing 2 Q8NC56 Nucleus inner membrane; Multi-pass membrane protein. Note=Lamina-associated protein residing in the inner nuclear membrane (INM). Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery. Integral to membrane (GO:0016021); Nucleus (GO:0005634) none,15561729,17081983 nucleus membrane 100 2 nucleus. nucleus membrane multiple Amniota Amniota Metazoa LEMD3 HGNC:28887 LEM domain containing 3 Q9Y2U8 Nucleus inner membrane; Multi-pass membrane protein. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 10671519,11896184 nucleus membrane 100 2 endoplasmic reticulum. nucleus. nucleus membrane multiple Deuterostomia Bilateria Eukaryota LENEP HGNC:14429 lens epithelial protein Q9Y5L5 Nucleus (GO:0005634) secreted 41 0 secreted secreted Euarchontoglires Eutheria Euteleostomi LENG1 HGNC:15502 leukocyte receptor cluster (LRC) member 1 Q96BZ8 nucleus 62 0 nucleus nucleus Theria Bilateria NA LENG8 HGNC:15500 leukocyte receptor cluster (LRC) member 8 Q96PV6 nucleus 19 2 nucleus nucleus Eukaryota Eukaryota NA LENG9 HGNC:16306 leukocyte receptor cluster (LRC) member 9 Q96B70 secreted 28 0 secreted secreted Euteleostomi Deuterostomia NA LEO1 HGNC:30401 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Q8WVC0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms LEP HGNC:6553 leptin P41159 Secreted. Extracellular (GO:0005576) 11508653 secreted 100 0 secreted secreted Mammalia Euteleostomi Euteleostomi LEPR HGNC:6554 leptin receptor P48357 Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable). Cell surface (GO:0009986); Early endosome (GO:0005769); Plasma membrane (GO:0005886) 16482222,16482222,8548812,16482222 plasma membrane 20 2 endosome. plasma membrane. secreted multiple Euteleostomi Euteleostomi Chordata LEPRE1 HGNC:19316 leucine proline-enriched proteoglycan (leprecan) 1 Q32P28 Endoplasmic reticulum (By similarity). Secreted, extracellular space, extracellular matrix (By similarity). Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Integral to membrane (GO:0016021) 10951563,10951563,10455179 secreted 26 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms LEPREL1 HGNC:19317 leprecan-like 1 Q8IVL5 Endoplasmic reticulum. Golgi apparatus. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 15063763,15063763 secreted 20 0 endoplasmic reticulum. golgi apparatus multiple Chordata Chordata Cell.Organisms LEPREL2 HGNC:19318 leprecan-like 2 Q8IVL6 Endoplasmic reticulum (By similarity). secreted 18 0 secreted secreted Human Euteleostomi NA LEPREL4 HGNC:16946 leprecan-like 4 Q92791 Nucleus, nucleolus. Chromosome. Note=Localized uniformly throughout the granular component of the nucleolus and on the surface of chromosomes during mitosis. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa LEPROT HGNC:29477 leptin receptor overlapping transcript O15243 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Endosome membrane (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 30 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Eukaryota LEPROTL1 HGNC:6555 leptin receptor overlapping transcript-like 1 O95214 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11342119 golgi apparatus membrane 22 4 plasma membrane plasma membrane Opisthokonta Eukaryota Eukaryota LETM1 HGNC:6556 leucine zipper-EF-hand containing transmembrane protein 1 O95202 Mitochondrion inner membrane; Single-pass membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 10486213,15598749 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane. plasma membrane multiple Eukaryota Eukaryota Eukaryota LETM2 HGNC:14648 leucine zipper-EF-hand containing transmembrane protein 2 Q2VYF4 Mitochondrion inner membrane; Single-pass membrane protein (By similarity). mitochondrion membrane 72 2 mitochondrion membrane mitochondrion membrane Amniota Amniota Eukaryota LETMD1 HGNC:24241 LETM1 domain containing 1 Q6P1Q0 Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm (GO:0005737) 12879013 mitochondrion membrane 100 2 cytoplasm. mitochondrion membrane multiple Bilateria Bilateria Eukaryota LEUTX HGNC:31953 leucine twenty homeobox A8MZ59 Nucleus (Potential). nucleus 26 0 nucleus nucleus Homininae Homininae Euarchontoglires LFNG HGNC:6560 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Q8NES3 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 10934472,9187150 golgi apparatus membrane 26 0 golgi apparatus. secreted multiple Deuterostomia Bilateria Eukaryota LGALS1 HGNC:6561 lectin, galactoside-binding, soluble, 1 P09382 Secreted, extracellular space, extracellular matrix. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9683529,9683529,1996404,7750127 secreted 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Bilateria LGALS12 HGNC:15788 lectin, galactoside-binding, soluble, 12 Q96DT0 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11435439,11435439 nucleus 100 0 mitochondrion. nucleus multiple Eutheria Mammalia Metazoa LGALS13 HGNC:15449 lectin, galactoside-binding, soluble, 13 Q9UHV8 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11742106,15009185,15009185 nucleus 59 0 cytoplasm cytoplasm Catarrhini Catarrhini Bilateria LGALS14 HGNC:30054 lectin, galactoside-binding, soluble, 14 Q8TCE9 Nucleus. Nucleus (GO:0005634) 11997112 nucleus 100 0 nucleus nucleus Human Catarrhini Bilateria LGALS16 HGNC:40039 lectin, galactoside-binding, soluble, 16 A8MUM7 nucleus 50 0 nucleus nucleus NA NA Bilateria LGALS2 HGNC:6562 lectin, galactoside-binding, soluble, 2 P05162 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 1375225,1375225 secreted 30 0 cytoplasm. secreted multiple Mammalia Euteleostomi Bilateria LGALS3 HGNC:6563 lectin, galactoside-binding, soluble, 3 P17931 Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 12439750,12439750,12439750 cytoplasm 28 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Metazoa LGALS3BP HGNC:6564 lectin, galactoside-binding, soluble, 3 binding protein Q08380 Secreted. Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 9501082 secreted 100 0 secreted secreted Eutheria Eukaryota Eukaryota LGALS4 HGNC:6565 lectin, galactoside-binding, soluble, 4 P56470 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9162064,9162064 cytoplasm 21 0 cytoplasm cytoplasm Mammalia Bilateria Metazoa LGALS7 HGNC:6568 lectin, galactoside-binding, soluble, 7 P47929 Cytoplasm. Nucleus. Secreted (Potential). Note=May be secreted by a non-classical secretory pathway. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 7534301,16188874,7534301,12523890 cytoplasm 20 0 cytoplasm. nucleus. secreted multiple Mammalia Mammalia Metazoa LGALS7B HGNC:34447 lectin, galactoside-binding, soluble, 7B P47929 Cytoplasm. Nucleus. Secreted (Potential). Note=May be secreted by a non-classical secretory pathway. cytoplasm 20 0 cytoplasm. nucleus multiple Mammalia Mammalia Metazoa LGALS8 HGNC:6569 lectin, galactoside-binding, soluble, 8 O00214 Cytoplasm (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10980616,11839721,10980616,8692978,11839721,8692978,11839721 cytoplasm 76 0 cytoplasm. nucleus. secreted multiple Tetrapoda Deuterostomia Metazoa LGALS9 HGNC:6570 lectin, galactoside-binding, soluble, 9 O00182 Cytoplasm (By similarity). Secreted (By similarity). Note=May also be secreted by a non-classical secretory pathway (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12223516,12223516,9642261 cytoplasm 20 0 cytoplasm. secreted multiple Chordata Bilateria Metazoa LGALS9B HGNC:24842 lectin, galactoside-binding, soluble, 9B Q3B8N2 cytoplasm 20 0 cytoplasm cytoplasm Chordata Bilateria Metazoa LGALS9C HGNC:33874 lectin, galactoside-binding, soluble, 9C Q6DKI2 cytoplasm 20 0 cytoplasm cytoplasm Chordata Bilateria Metazoa LGALSL HGNC:25012 lectin, galactoside-binding-like Q3ZCW2 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria LGI1 HGNC:6572 leucine-rich, glioma inactivated 1 O95970 Secreted. Cell junction, synapse (By similarity). Note=Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum. secreted 96 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LGI2 HGNC:18710 leucine-rich repeat LGI family, member 2 Q8N0V4 Secreted (Potential). secreted 45 0 secreted secreted Euteleostomi Euteleostomi Holozoa LGI3 HGNC:18711 leucine-rich repeat LGI family, member 3 Q8N145 Secreted (Potential). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Found in the synaptosomal membrane fraction (By similarity). secreted 41 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LGI4 HGNC:18712 leucine-rich repeat LGI family, member 4 Q8N135 Secreted (Potential). Extracellular (GO:0005576); Integral to membrane (GO:0016021) ,12023020 secreted 37 0 secreted secreted Mammalia Mammalia Cell.Organisms LGMN HGNC:9472 legumain Q99538 Lysosome (By similarity). Lysosome (GO:0005764); Mitochondrion (GO:0005739) 9742219,15598749 vacuole 30 0 lysosome. mitochondrion multiple Chordata Eukaryota Cell.Organisms LGR4 HGNC:13299 leucine-rich repeat containing G protein-coupled receptor 4 Q9BXB1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Amniota Bilateria Cell.Organisms LGR5 HGNC:4504 leucine-rich repeat containing G protein-coupled receptor 5 O75473 Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). Plasma membrane (GO:0005886) plasma membrane 45 7 golgi apparatus membrane. plasma membrane multiple Amniota Bilateria Cell.Organisms LGR6 HGNC:19719 leucine-rich repeat containing G protein-coupled receptor 6 Q9HBX8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10935549 plasma membrane 100 7 plasma membrane plasma membrane Amniota Bilateria Cell.Organisms LGSN HGNC:21016 lengsin, lens protein with glutamine synthetase domain Q5TDP6 cytoplasm 7 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms LHB HGNC:6584 luteinizing hormone beta polypeptide P01229 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 8961276,7513655 secreted 100 0 cytoplasm. secreted multiple Theria Euteleostomi Chordata LHCGR HGNC:6585 luteinizing hormone/choriogonadotropin receptor P22888 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9558473 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms LHFP HGNC:6586 lipoma HMGIC fusion partner Q9Y693 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 12 3 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa LHFPL1 HGNC:6587 lipoma HMGIC fusion partner-like 1 Q86WI0 Membrane; Multi-pass membrane protein (Potential). plasma membrane 14 3 plasma membrane plasma membrane Theria Tetrapoda Metazoa LHFPL2 HGNC:6588 lipoma HMGIC fusion partner-like 2 Q6ZUX7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 6 4 plasma membrane plasma membrane Deuterostomia Bilateria Metazoa LHFPL3 HGNC:6589 lipoma HMGIC fusion partner-like 3 Q86UP9 Membrane; Multi-pass membrane protein (Potential). plasma membrane 59 4 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa LHFPL4 HGNC:29568 lipoma HMGIC fusion partner-like 4 Q7Z7J7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 53 4 plasma membrane plasma membrane Eutheria Euteleostomi Metazoa LHFPL5 HGNC:21253 lipoma HMGIC fusion partner-like 5 Q8TAF8 Cell membrane; Multi-pass membrane protein (By similarity). Note=Efficient localization to the plasma membrane requires the presence of PCDH15 (By similarity). Integral to membrane (GO:0016021) plasma membrane 98 4 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa LHPP HGNC:30042 phospholysine phosphohistidine inorganic pyrophosphate phosphatase Q9H008 Cytoplasm. Nucleus. cytoplasm 64 0 cytoplasm. nucleus multiple Theria Bilateria Cell.Organisms LHX1 HGNC:6593 LIM homeobox 1 P48742 Nucleus (Probable). Nucleus (GO:0005634) nucleus 99 0 nucleus nucleus Bilateria Bilateria Eukaryota LHX2 HGNC:6594 LIM homeobox 2 P50458 Nucleus (Probable). Nucleus (GO:0005634) 10593900 nucleus 68 0 nucleus nucleus Euteleostomi Bilateria Eukaryota LHX3 HGNC:6595 LIM homeobox 3 Q9UBR4 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634); Nuclear matrix (GO:0016363) 10598593/10818088,10818088 nucleus 32 0 nucleus nucleus Bilateria Bilateria Eukaryota LHX4 HGNC:21734 LIM homeobox 4 Q969G2 Nucleus (Potential). Nucleus (GO:0005634) 10788441 nucleus 35 0 nucleus nucleus Bilateria Bilateria Eukaryota LHX5 HGNC:14216 LIM homeobox 5 Q9H2C1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 70 0 nucleus nucleus Euteleostomi Bilateria Eukaryota LHX6 HGNC:21735 LIM homeobox 6 Q9UPM6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 25 0 nucleus nucleus Bilateria Bilateria Eukaryota LHX8 HGNC:28838 LIM homeobox 8 Q68G74 Nucleus (Probable). nucleus 24 0 nucleus nucleus Euteleostomi Bilateria Eukaryota LHX9 HGNC:14222 LIM homeobox 9 Q9NQ69 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 98 0 nucleus nucleus Deuterostomia Bilateria Eukaryota LIAS HGNC:16429 lipoic acid synthetase O43766 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11389890 mitochondrion 88 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms LIF HGNC:6596 leukemia inhibitory factor P15018 Secreted. secreted 100 0 secreted secreted Tetrapoda Tetrapoda Tetrapoda LIFR HGNC:6597 leukemia inhibitory factor receptor alpha P42702 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10858440,10858440 secreted 11 1 endoplasmic reticulum. plasma membrane. secreted multiple Euteleostomi Euteleostomi Metazoa LIG1 HGNC:6598 ligase I, DNA, ATP-dependent P18858 Nucleus. Nucleus (GO:0005634) 934827,7489727,8557490,2197279 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms LIG3 HGNC:6600 ligase III, DNA, ATP-dependent P49916 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 7760816,10207110,17081983,10207110 nucleus 100 0 mitochondrion. nucleus multiple Deuterostomia Eukaryota Cell.Organisms LIG4 HGNC:6601 ligase IV, DNA, ATP-dependent P49917 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15333585,12589063,8798671,16439205,12589063 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms LILRA1 HGNC:6602 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 O75019 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 58 1 plasma membrane plasma membrane Theria Theria NA LILRA2 HGNC:6603 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 Q8N149 Membrane; Single-pass type I membrane protein. plasma membrane 53 0 n/a n/a NA NA NA LILRA3 HGNC:6604 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 Q8N6C8 Secreted (Probable). Extracellular (GO:0005576) 9278324,9382880,12651072 plasma membrane 59 0 secreted secreted Theria Theria NA LILRA4 HGNC:15503 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 P59901 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 62 1 plasma membrane plasma membrane NA NA NA LILRA5 HGNC:16309 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 A6NI73 Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Isoform 2: Membrane; Single-pass type I membrane protein. Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Plasma membrane (GO:0005886) 12393390 plasma membrane 55 1 plasma membrane. secreted multiple Theria Theria NA LILRA6 HGNC:15495 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 Q6PI73 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10941842 plasma membrane 91 1 plasma membrane plasma membrane NA NA NA LILRB1 HGNC:6605 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 Q8NHL6 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9285411 plasma membrane 65 1 plasma membrane plasma membrane Theria Theria NA LILRB2 HGNC:6606 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 Q8N423 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9548455,9079806 plasma membrane 63 1 plasma membrane plasma membrane Theria Theria NA LILRB3 HGNC:6607 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 O75022 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9278324 plasma membrane 100 1 plasma membrane plasma membrane Theria Theria NA LILRB4 HGNC:6608 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 Q8NHJ6 Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment. Plasma membrane (GO:0005886) 9151699 plasma membrane 100 1 plasma membrane plasma membrane Euarchontoglires Euarchontoglires NA LILRB5 HGNC:6609 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 O75023 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9548455 plasma membrane 64 1 plasma membrane plasma membrane Theria Theria NA LIM2 HGNC:6610 lens intrinsic membrane protein 2, 19kDa P55344 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8666393 golgi apparatus membrane 74 3 plasma membrane plasma membrane Chordata Chordata Chordata LIMA1 HGNC:24636 LIM domain and actin binding 1 Q9UHB6 Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co- localizes with actin stress fibers and focal adhesion plaques. Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 10618726,17081983,15561729,17081983 cytoplasm 71 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota LIMCH1 HGNC:29191 LIM and calponin homology domains 1 Q9UPQ0 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 11 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota LIMD1 HGNC:6612 LIM domains containing 1 Q9UGP4 Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Co-localizes with VCL in the focal adhesions. Down- regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis. Nucleus (GO:0005634); Plasma membrane (GO:0005886) ,16137684,16137684 secreted 44 0 cytoplasm. nucleus multiple Amniota Deuterostomia Eukaryota LIMD2 HGNC:28142 LIM domain containing 2 Q9BT23 cytoplasm 60 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota LIME1 HGNC:26016 Lck interacting transmembrane adaptor 1 Q9H400 Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen- presenting cell. plasma membrane 100 0 plasma membrane plasma membrane Human Euteleostomi Mammalia LIMK1 HGNC:6613 LIM domain kinase 1 P53667 Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 8537403,14530263/14530263,15023529,8537403,14530263,10196227 cytoplasm 45 0 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Bilateria NA LIMK2 HGNC:6614 LIM domain kinase 2 P53671 Isoform LIMK2a: Cytoplasm. Nucleus. Isoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8954941,8954941/8537403,8954941,8954941 cytoplasm 91 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms LIMS1 HGNC:6616 LIM and senescent cell antigen-like domains 1 P48059 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10022929,12528177,12528177 cytoplasm 19 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota LIMS2 HGNC:16084 LIM and senescent cell antigen-like domains 2 Q7Z4I7 Nucleus (Potential). Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus (GO:0005634); Extracellular matrix (GO:0005578); Focal adhesion (GO:0005925) 12167643,12167643,12167643 cytoplasm 20 0 nucleus. secreted multiple Bilateria Eukaryota Eukaryota LIMS3 HGNC:30047 LIM and senescent cell antigen-like domains 3 P0CW19 Cytoplasm (Potential). nucleus 31 0 nucleus nucleus NA NA Eukaryota LIMS3L HGNC:39941 LIM and senescent cell antigen-like domains 3-like P0CW20 nucleus 28 0 nucleus nucleus NA NA Eukaryota LIN28A HGNC:15986 lin-28 homolog A (C. elegans) Q9H9Z2 Cytoplasm. Nucleus, nucleolus. Note=Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules. cytoplasm 38 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms LIN28B HGNC:32207 lin-28 homolog B (C. elegans) Q6ZN17 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively. Nucleus (GO:0005634) cytoplasm 43 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms LIN37 HGNC:33234 lin-37 homolog (C. elegans) Q96GY3 nucleus 91 0 nucleus nucleus Theria Bilateria NA LIN52 HGNC:19856 lin-52 homolog (C. elegans) Q52LA3 Nucleus (GO:0005634) 17081983 nucleus 65 0 nucleus nucleus Euteleostomi Bilateria Metazoa LIN54 HGNC:25397 lin-54 homolog (C. elegans) Q6MZP7 Nucleus (Probable). nucleus 38 0 nucleus nucleus Bilateria Eukaryota Eukaryota LIN7A HGNC:17787 lin-7 homolog A (C. elegans) O14910 Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein (By similarity). Cell junction, tight junction (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9753324,14722086,15494546 cytoplasm 34 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa LIN7B HGNC:17788 lin-7 homolog B (C. elegans) Q9HAP6 Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein (By similarity). Cell junction, tight junction (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11742811,14596909,14596909 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa LIN7C HGNC:17789 lin-7 homolog C (C. elegans) Q9NUP9 Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein (By similarity). Cell junction, tight junction (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. Extracellular (GO:0005576) 10341223 secreted 24 0 secreted secreted Bilateria Bilateria Holozoa LIN9 HGNC:30830 lin-9 homolog (C. elegans) Q5TKA1 Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin. Nucleus (GO:0005634) 15538385 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota LINGO1 HGNC:21205 leucine rich repeat and Ig domain containing 1 Q96FE5 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 14686891 plasma membrane 99 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms LINGO2 HGNC:21207 leucine rich repeat and Ig domain containing 2 Q7L985 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 51 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms LINGO3 HGNC:21206 leucine rich repeat and Ig domain containing 3 P0C6S8 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 45 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms LINGO4 HGNC:31814 leucine rich repeat and Ig domain containing 4 Q6UY18 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 32 1 plasma membrane plasma membrane Theria Theria Cell.Organisms LINS HGNC:30922 lines homolog (Drosophila) Q8NG48 nucleus 72 2 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta LIPA HGNC:6617 lipase A, lysosomal acid, cholesterol esterase P38571 Lysosome. Lysosome (GO:0005764) 12162818 secreted 48 0 lysosome lysosome Opisthokonta Eukaryota Cell.Organisms LIPC HGNC:6619 lipase, hepatic P11150 Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12700335,12700335 secreted 100 0 secreted secreted Theria Euteleostomi Cell.Organisms LIPE HGNC:6621 lipase, hormone-sensitive Q05469 Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 12832420,10694408,14745722,14745722 secreted 23 0 cytoplasm. golgi apparatus. nucleus multiple Theria Bilateria Cell.Organisms LIPF HGNC:6622 lipase, gastric P07098 Secreted. Extracellular (GO:0005576) 11241664,10700046,9468252 secreted 100 0 secreted secreted Opisthokonta Eukaryota Cell.Organisms LIPG HGNC:6623 lipase, endothelial Q9Y5X9 Secreted. Extracellular (GO:0005576) 14667806 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LIPH HGNC:18483 lipase, member H Q8WWY8 Secreted. Membrane; Peripheral membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12213196,12063250 secreted 19 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LIPI HGNC:18821 lipase, member I Q6XZB0 Isoform 1: Membrane. Secreted. Isoform 2: Membrane. Note=May associate with lipid draft. Plasma membrane (GO:0005886) 12963729 secreted 20 0 secreted secreted Homininae Mammalia Cell.Organisms LIPJ HGNC:21773 lipase, family member J Q5W064 secreted 48 0 secreted secreted Theria Theria Cell.Organisms LIPK HGNC:23444 lipase, family member K Q5VXJ0 Secreted (Potential). secreted 54 0 secreted secreted Theria Opisthokonta Cell.Organisms LIPM HGNC:23455 lipase, family member M Q5VYY2 Secreted (Potential). secreted 44 0 secreted secreted Mammalia Mammalia Cell.Organisms LIPN HGNC:23452 lipase, family member N Q5VXI9 Secreted (Potential). secreted 39 0 secreted secreted Theria Bilateria Cell.Organisms LIPT1 HGNC:29569 lipoyltransferase 1 Q9Y234 Mitochondrion. Mitochondrion (GO:0005739) 9405389,8206978 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms LIPT2 HGNC:37216 lipoyl(octanoyl) transferase 2 (putative) A6NK58 Mitochondrion (Potential). mitochondrion 19 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms LITAF HGNC:16841 lipopolysaccharide-induced TNF factor Q99732 Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with membranes of lysosomes. Nucleus (GO:0005634) nucleus 33 1 nucleus nucleus Bilateria Eukaryota Eukaryota LIX1 HGNC:18581 Lix1 homolog (chicken) Q8N485 cytoplasm 32 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa LIX1L HGNC:28715 Lix1 homolog (mouse)-like Q8IVB5 secreted 44 0 secreted secreted Theria Bilateria Eumetazoa LKAAEAR1 HGNC:33718 LKAAEAR motif containing 1 Q8TD35 nucleus 59 0 nucleus nucleus Euarchontoglires Chordata Metazoa LLGL1 HGNC:6628 lethal giant larvae homolog 1 (Drosophila) Q15334 Early endosome membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (By similarity). Golgi apparatus membrane (By similarity). Cell projection, axon (By similarity). Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cell junction (GO:0030054) 7542763,18793635,18793635,18793635 cytoplasm 48 0 cytoplasm cytoplasm Deuterostomia Eukaryota Holozoa LLGL2 HGNC:6629 lethal giant larvae homolog 2 (Drosophila) Q6P1M3 Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells. Perinuclear region (GO:0048471) 15632202 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota LLPH HGNC:28229 LLP homolog, long-term synaptic facilitation (Aplysia) Q9BRT6 nucleus 98 0 nucleus nucleus Deuterostomia Deuterostomia Bilateria LMAN1 HGNC:6631 lectin, mannose-binding, 1 P49257 Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9546392,9546392 golgi apparatus membrane 21 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Bilateria Bilateria Eukaryota LMAN1L HGNC:6632 lectin, mannose-binding, 1 like Q9HAT1 Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 17 1 golgi apparatus membrane golgi apparatus membrane Mammalia Mammalia Eukaryota LMAN2 HGNC:16986 lectin, mannose-binding 2 Q12907 Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10444376,10444376,15598749 golgi apparatus membrane 98 1 cytoplasm. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. mitochondrion multiple Opisthokonta Eukaryota Eukaryota LMAN2L HGNC:19263 lectin, mannose-binding 2-like Q9H0V9 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12878160,12878160,12609988,12878160 golgi apparatus membrane 48 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. plasma membrane multiple Opisthokonta Eukaryota Eukaryota LMBR1 HGNC:13243 limb development membrane protein 1 Q8WVP7 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 11333865 plasma membrane 51 9 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota LMBR1L HGNC:18268 limb development membrane protein 1-like Q6UX01 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11287427 plasma membrane 100 9 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota LMBRD1 HGNC:23038 LMBR1 domain containing 1 Q9NUN5 Lysosome membrane; Multi-pass membrane protein. golgi apparatus membrane 75 9 lysosome membrane lysosome membrane Deuterostomia Eukaryota Eukaryota LMBRD2 HGNC:25287 LMBR1 domain containing 2 Q68DH5 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 9 9 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota LMCD1 HGNC:6633 LIM and cysteine-rich domains 1 Q9NZU5 Cytoplasm (By similarity). Nucleus (By similarity). Note=May shuttle between the cytoplasm and the nucleus (By similarity). nucleus 17 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota LMF1 HGNC:14154 lipase maturation factor 1 Q96S06 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Cell.Organisms Cell.Organisms LMF2 HGNC:25096 lipase maturation factor 2 Q9BU23 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 20 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms LMLN HGNC:15991 leishmanolysin-like (metallopeptidase M8 family) Q96KR4 Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells. Plasma membrane (GO:0005886) cytoplasm 32 1 cytoplasm. lipid droplet multiple Eukaryota Eukaryota Eukaryota LMNA HGNC:6636 lamin A/C P02545 Nucleus. Nucleus envelope. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 17081983,17081983/8838815,11792809,17081983,11792809,17081983,12429849,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Holozoa LMNB1 HGNC:6637 lamin B1 P20700 Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 7557986,17081983,11790298,15635413,15598749,17081983 nucleus 48 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Holozoa LMNB2 HGNC:6638 lamin B2 Q03252 Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8543011,3515346,16319058,17081983,17081983 nucleus 46 0 cytoplasm. nucleus multiple Bilateria Eukaryota Holozoa LMO1 HGNC:6641 LIM domain only 1 (rhombotin 1) P25800 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8876198,8595880,8595880 nucleus 98 0 cytoplasm. nucleus multiple Theria Bilateria Eukaryota LMO2 HGNC:6642 LIM domain only 2 (rhombotin-like 1) P25791 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9736723,9736723 nucleus 99 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota LMO3 HGNC:6643 LIM domain only 3 (rhombotin-like 2) Q8TAP4 nucleus 87 0 nucleus nucleus Theria Euteleostomi Eukaryota LMO4 HGNC:6644 LIM domain only 4 P61968 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9736723,9736723 nucleus 39 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota LMO7 HGNC:6646 LIM domain 7 Q8WWI1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9826547,17081983,9826547,17081983 golgi apparatus membrane 36 1 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota LMO7DN HGNC:44370 LMO7 downstream neighbor F2Z398 cytoplasm 46 1 cytoplasm cytoplasm NA NA Opisthokonta LMOD1 HGNC:6647 leiomodin 1 (smooth muscle) P29536 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 10520227 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms LMOD2 HGNC:6648 leiomodin 2 (cardiac) Q6P5Q4 cytoplasm 30 0 cytoplasm cytoplasm Human Euteleostomi Cell.Organisms LMOD3 HGNC:6649 leiomodin 3 (fetal) Q0VAK6 Cytoplasm, cytoskeleton (By similarity). cytoplasm 30 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta LMTK2 HGNC:17880 lemur tyrosine kinase 2 Q8IWU2 Membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12832520,12393858,17081983 cytoplasm 16 2 cytoplasm. golgi apparatus. plasma membrane multiple Tetrapoda Deuterostomia Cell.Organisms LMTK3 HGNC:19295 lemur tyrosine kinase 3 Q96Q04 Membrane; Single-pass membrane protein (Potential). plasma membrane 20 2 plasma membrane plasma membrane Catarrhini Euteleostomi Cell.Organisms LMX1A HGNC:6653 LIM homeobox transcription factor 1, alpha Q8TE12 Nucleus (By similarity). Nucleus (GO:0005634) 7698771 nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota LMX1B HGNC:6654 LIM homeobox transcription factor 1, beta O60663 Nucleus (Potential). Nucleus (GO:0005634) nucleus 91 0 nucleus nucleus Bilateria Bilateria Eukaryota LNP1 HGNC:28014 leukemia NUP98 fusion partner 1 A1A4G5 nucleus 88 0 nucleus nucleus Catarrhini Amniota Amniota LNPEP HGNC:6656 leucyl/cystinyl aminopeptidase Q9UIQ6 Cell membrane; Single-pass type II membrane protein. Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8550619,9733056 endoplasmic reticulum membrane 32 1 plasma membrane. secreted multiple Chordata Bilateria Cell.Organisms LNX1 HGNC:6657 ligand of numb-protein X 1, E3 ubiquitin protein ligase Q8TBB1 Cytoplasm (By similarity). cytoplasm 86 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota LNX2 HGNC:20421 ligand of numb-protein X 2 Q8N448 cytoplasm 44 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota LOH12CR1 HGNC:17950 loss of heterozygosity, 12, chromosomal region 1 Q969J3 nucleus 80 0 nucleus nucleus Bilateria Bilateria Opisthokonta LONP1 HGNC:9479 lon peptidase 1, mitochondrial P36776 Mitochondrion matrix. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783) 7961901,15561729,12082077 mitochondrion 100 0 endoplasmic reticulum. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms LONP2 HGNC:20598 lon peptidase 2, peroxisomal Q86WA8 Peroxisome matrix. peroxisome 100 0 peroxisome peroxisome Cell.Organisms Cell.Organisms Cell.Organisms LONRF1 HGNC:26302 LON peptidase N-terminal domain and ring finger 1 Q17RB8 cytoplasm 40 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms LONRF2 HGNC:24788 LON peptidase N-terminal domain and ring finger 2 Q1L5Z9 cytoplasm 42 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms LONRF3 HGNC:21152 LON peptidase N-terminal domain and ring finger 3 Q496Y0 cytoplasm 43 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms LOR HGNC:6663 loricrin P23490 Cytoplasm. Nucleus, nucleoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8274037,2007607,8248167 cytoplasm 32 0 cytoplasm. nucleus multiple Human Human NA LOX HGNC:6664 lysyl oxidase P28300 Secreted, extracellular space. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2874833,11642359,11642359 secreted 100 0 cytoplasm. nucleus. secreted multiple Chordata Cell.Organisms Cell.Organisms LOXHD1 HGNC:26521 lipoxygenase homology domains 1 Q8IVV2 Cell projection, stereocilium (By similarity). secreted 31 0 secreted secreted Deuterostomia Eukaryota Cell.Organisms LOXL1 HGNC:6665 lysyl oxidase-like 1 Q08397 Secreted, extracellular space (Potential). Nucleus (GO:0005634); Extracellular (GO:0005576) 14745449,7689553,14745449 secreted 63 0 nucleus. secreted multiple Theria Euteleostomi Cell.Organisms LOXL2 HGNC:6666 lysyl oxidase-like 2 Q9Y4K0 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12686136,11162352,11162352 secreted 36 0 cytoplasm. nucleus. secreted multiple Deuterostomia Bilateria Cell.Organisms LOXL3 HGNC:13869 lysyl oxidase-like 3 P58215 Secreted, extracellular space (Potential). Extracellular (GO:0005576) 11284725 secreted 34 0 secreted secreted Deuterostomia Bilateria Cell.Organisms LOXL4 HGNC:17171 lysyl oxidase-like 4 Q96JB6 Secreted, extracellular space (Potential). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 7706256,17081983 secreted 40 0 cytoplasm. secreted multiple Deuterostomia Bilateria Cell.Organisms LPA HGNC:6667 lipoprotein, Lp(a) P08519 Extracellular (GO:0005576) 3670400 secreted 59 0 secreted secreted Amniota Bilateria Cell.Organisms LPAR1 HGNC:3166 lysophosphatidic acid receptor 1 Q92633 Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. Plasma membrane (GO:0005886) 11948806 plasma membrane 90 7 plasma membrane plasma membrane Chordata Chordata Metazoa LPAR2 HGNC:3168 lysophosphatidic acid receptor 2 Q9HBW0 Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. Plasma membrane (GO:0005886); Apical membrane (GO:0016327) 9525886,,16203867, plasma membrane 44 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa LPAR3 HGNC:14298 lysophosphatidic acid receptor 3 Q9UBY5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12884281 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa LPAR4 HGNC:4478 lysophosphatidic acid receptor 4 Q99677 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9073069 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Metazoa LPAR5 HGNC:13307 lysophosphatidic acid receptor 5 Q9H1C0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11574155 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa LPAR6 HGNC:15520 lysophosphatidic acid receptor 6 P43657 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa LPCAT1 HGNC:25718 lysophosphatidylcholine acyltransferase 1 Q8NF37 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 16704971,16704971 endoplasmic reticulum membrane 24 3 endoplasmic reticulum. golgi apparatus multiple Euteleostomi Eukaryota Cell.Organisms LPCAT2 HGNC:26032 lysophosphatidylcholine acyltransferase 2 Q7L5N7 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). endoplasmic reticulum membrane 31 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Cell.Organisms LPCAT3 HGNC:30244 lysophosphatidylcholine acyltransferase 3 Q6P1A2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota LPCAT4 HGNC:30059 lysophosphatidylcholine acyltransferase 4 Q643R3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Perinuclear region (GO:0048471) 16243729,16243729 endoplasmic reticulum membrane 100 3 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Euteleostomi Cell.Organisms LPGAT1 HGNC:28985 lysophosphatidylglycerol acyltransferase 1 Q92604 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 15485873,15485873 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Chordata Bilateria Eukaryota LPHN1 HGNC:20973 latrophilin 1 O94910 Cell membrane; Multi-pass membrane protein. Cell projection, axon (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts (By similarity). Plasma membrane (GO:0005886) 10964907 plasma membrane 59 7 plasma membrane plasma membrane Chordata Bilateria Eukaryota LPHN2 HGNC:18582 latrophilin 2 O95490 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10030676 plasma membrane 100 7 plasma membrane plasma membrane Chordata Bilateria Holozoa LPHN3 HGNC:20974 latrophilin 3 Q9HAR2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Chordata Bilateria NA LPIN1 HGNC:13345 lipin 1 Q14693 Nucleus membrane (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum membrane (By similarity). Nucleus (GO:0005634) 11138012 cytoplasm 30 0 nucleus nucleus Eukaryota Eukaryota Eukaryota LPIN2 HGNC:14450 lipin 2 Q92539 Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum membrane (By similarity). Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 cytoplasm 32 0 nucleus nucleus Eukaryota Eukaryota Eukaryota LPIN3 HGNC:14451 lipin 3 Q9BQK8 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 24 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota LPL HGNC:6677 lipoprotein lipase P06858 Cell membrane (By similarity); Lipid-anchor, GPI-anchor (By similarity). Secreted (By similarity). Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 3355847,11834518 secreted 38 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LPO HGNC:6678 lactoperoxidase P22079 Secreted, extracellular space. Extracellular (GO:0005576) 10814547,9030719 secreted 100 0 secreted secreted Chordata Chordata Cell.Organisms LPP HGNC:6679 LIM domain containing preferred translocation partner in lipoma Q93052 Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12760907,10637295,16137684,10637295,17081983,16137684 secreted 30 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota LPXN HGNC:14061 leupaxin O60711 Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region (By similarity). Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9565592,18497331,18497331 cytoplasm 20 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota LRAT HGNC:6685 lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) O95237 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Rough endoplasmic reticulum (By similarity). Endosome, multivesicular body (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity). Endoplasmic reticulum (GO:0005783) 9767084 secreted 11 1 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Cell.Organisms LRBA HGNC:1742 LPS-responsive vesicle trafficking, beach and anchor containing P50851 Cell membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (By similarity). Golgi apparatus, trans-Golgi network (By similarity). Lysosome (By similarity). Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023) 11254716,11254716,11254716,11254716,11254716 endoplasmic reticulum 24 2 endoplasmic reticulum. golgi apparatus. lysosome. plasma membrane multiple Bilateria Eukaryota Cell.Organisms LRCH1 HGNC:20309 leucine-rich repeats and calponin homology (CH) domain containing 1 Q9Y2L9 plasma membrane 19 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms LRCH2 HGNC:29292 leucine-rich repeats and calponin homology (CH) domain containing 2 Q5VUJ6 cytoplasm 20 0 cytoplasm cytoplasm Chordata Chordata NA LRCH3 HGNC:28637 leucine-rich repeats and calponin homology (CH) domain containing 3 Q96II8 Secreted (Potential). cytoplasm 21 0 cytoplasm cytoplasm Tetrapoda Bilateria Cell.Organisms LRCH4 HGNC:6691 leucine-rich repeats and calponin homology (CH) domain containing 4 O75427 Nucleus (GO:0005634);Cytoplasm (GO:0005737) 16449650/17081983 plasma membrane 17 1 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms LRCOL1 HGNC:44160 leucine rich colipase-like 1 A6NCL2 secreted 100 0 secreted secreted NA NA NA LRFN1 HGNC:29290 leucine rich repeat and fibronectin type III domain containing 1 Q9P244 Membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane (By similarity). Cell surface (GO:0009986) 16828986 cytoplasm 17 1 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms LRFN2 HGNC:21226 leucine rich repeat and fibronectin type III domain containing 2 Q9ULH4 Membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane (By similarity). secreted 15 1 secreted secreted Euteleostomi Deuterostomia Cell.Organisms LRFN3 HGNC:28370 leucine rich repeat and fibronectin type III domain containing 3 Q9BTN0 Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). plasma membrane 18 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms LRFN4 HGNC:28456 leucine rich repeat and fibronectin type III domain containing 4 Q6PJG9 Membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 17 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms LRFN5 HGNC:20360 leucine rich repeat and fibronectin type III domain containing 5 Q96NI6 Membrane (By similarity); Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 17 1 secreted secreted Euteleostomi Deuterostomia Cell.Organisms LRG1 HGNC:29480 leucine-rich alpha-2-glycoprotein 1 P02750 Secreted. Extracellular (GO:0005576) 3856868,16188874 secreted 100 0 secreted secreted Theria Euteleostomi Cell.Organisms LRGUK HGNC:21964 leucine-rich repeats and guanylate kinase domain containing Q96M69 cytoplasm 19 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms LRIF1 HGNC:30299 ligand dependent nuclear receptor interacting factor 1 Q5T3J3 Nucleus matrix. nucleus 100 0 nucleus nucleus Amniota Euteleostomi Euteleostomi LRIG1 HGNC:17360 leucine-rich repeats and immunoglobulin-like domains 1 Q96JA1 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11414704 secreted 15 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms LRIG2 HGNC:20889 leucine-rich repeats and immunoglobulin-like domains 2 O94898 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 15145052,15145052 plasma membrane 15 1 cytoplasm. plasma membrane multiple Bilateria Bilateria Cell.Organisms LRIG3 HGNC:30991 leucine-rich repeats and immunoglobulin-like domains 3 Q6UXM1 Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4 (By similarity). secreted 16 1 secreted secreted Bilateria Bilateria Cell.Organisms LRIT1 HGNC:23404 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 Q9P2V4 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 10777785 endoplasmic reticulum membrane 74 1 endoplasmic reticulum endoplasmic reticulum Mammalia Euteleostomi Holozoa LRIT2 HGNC:23443 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 A6NDA9 Membrane; Single-pass type I membrane protein. endoplasmic reticulum membrane 17 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Holozoa LRIT3 HGNC:24783 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Q3SXY7 Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 21 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Cell.Organisms LRMP HGNC:6690 lymphoid-restricted membrane protein Q12912 Processed lymphoid-restricted membrane protein: Cytoplasm (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 8021504,8798562,9314557 nucleus 40 1 cytoplasm. endoplasmic reticulum multiple Euteleostomi Euteleostomi Eumetazoa LRP1 HGNC:6692 low density lipoprotein receptor-related protein 1 Q07954 Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit. Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit. Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Extracellular (GO:0005576); Nucleus (GO:0005634) 7961982,14645246,2112085,7961982,2112085,7961982,7961982,9295345,12888553 plasma membrane 25 1 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms LRP10 HGNC:14553 low density lipoprotein receptor-related protein 10 Q7Z4F1 Membrane; Single-pass type I membrane protein (Potential). Membrane, coated pit (By similarity). Plasma membrane (GO:0005886) plasma membrane 34 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa LRP11 HGNC:16936 low density lipoprotein receptor-related protein 11 Q86VZ4 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 29 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms LRP12 HGNC:31708 low density lipoprotein receptor-related protein 12 Q9Y561 Membrane; Single-pass type I membrane protein. Membrane, coated pit. Plasma membrane (GO:0005886) 12809483 plasma membrane 34 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa LRP1B HGNC:6693 low density lipoprotein receptor-related protein 1B Q9NZR2 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 30 1 secreted secreted Bilateria Bilateria Cell.Organisms LRP2 HGNC:6694 low density lipoprotein receptor-related protein 2 P98164 Membrane; Single-pass type I membrane protein. Membrane, coated pit. Plasma membrane (GO:0005886); Endosome (GO:0005768) 12713445,16415858 secreted 25 1 endosome. plasma membrane multiple Bilateria Bilateria Cell.Organisms LRP2BP HGNC:25434 LRP2 binding protein Q9P2M1 Cytoplasm. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm. Cytoplasm (GO:0005737) 12508107 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Cell.Organisms LRP3 HGNC:6695 low density lipoprotein receptor-related protein 3 O75074 Membrane; Single-pass type I membrane protein (Potential). Membrane, coated pit (By similarity). Plasma membrane (GO:0005886) 9693042 secreted 28 1 plasma membrane plasma membrane Amniota Euteleostomi Metazoa LRP4 HGNC:6696 low density lipoprotein receptor-related protein 4 O75096 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 9693030 plasma membrane 27 0 n/a n/a Bilateria Bilateria Cell.Organisms LRP5 HGNC:6697 low density lipoprotein receptor-related protein 5 O75197 Membrane; Single-pass type I membrane protein. Endoplasmic reticulum (By similarity). Note=Chaperoned to the plasma membrane by MESD (By similarity). Plasma membrane (GO:0005886) 9714764 nucleus 39 0 nucleus nucleus Bilateria Bilateria Cell.Organisms LRP5L HGNC:25323 low density lipoprotein receptor-related protein 5-like A4QPB2 secreted 82 0 secreted secreted Homininae Homininae Cell.Organisms LRP6 HGNC:6698 low density lipoprotein receptor-related protein 6 O75581 Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). Cytoplasm (GO:0005737); Cell surface (GO:0009986); Plasma membrane (GO:0005886) 16564009,16564009,9704021 secreted 39 0 cytoplasm. endoplasmic reticulum multiple Bilateria Bilateria Cell.Organisms LRP8 HGNC:6700 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Q14114 Cell membrane; Single-pass type I membrane protein (By similarity). Secreted (By similarity). Note=Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment (By similarity). Caveola (GO:0005901); Soluble fraction (GO:0005625) 11369809,12426372 secreted 30 2 n/a n/a Euteleostomi Bilateria Cell.Organisms LRPAP1 HGNC:6701 low density lipoprotein receptor-related protein associated protein 1 P30533 Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Nucleus (GO:0005634) 9010785,1400426,7510321,7512726,9010785,9010785,17000644 nucleus 54 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus. secreted multiple Bilateria Bilateria Eumetazoa LRPPRC HGNC:15714 leucine-rich pentatricopeptide repeat containing P42704 Mitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11827465,15561729,11827465,11827465 golgi apparatus 4 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Eukaryota Eukaryota LRR1 HGNC:19742 leucine rich repeat protein 1 Q96L50 cytoplasm 21 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms LRRC1 HGNC:14307 leucine rich repeat containing 1 Q9BTT6 Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized at the basolateral side of epithelial cells. plasma membrane 19 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms LRRC10 HGNC:20264 leucine rich repeat containing 10 Q5BKY1 Nucleus (By similarity). Nucleus (GO:0005634); Mitochondrion (GO:0005739) 14751244,14751244 nucleus 88 0 mitochondrion. nucleus multiple Euteleostomi Opisthokonta Cell.Organisms LRRC10B HGNC:37215 leucine rich repeat containing 10B A6NIK2 nucleus 31 0 nucleus nucleus Human Euteleostomi Cell.Organisms LRRC14 HGNC:20419 leucine rich repeat containing 14 Q15048 plasma membrane 26 0 n/a n/a Theria Euteleostomi Bilateria LRRC14B HGNC:37268 leucine rich repeat containing 14B A6NHZ5 secreted 57 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa LRRC15 HGNC:20818 leucine rich repeat containing 15 Q8TF66 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12923058,11785964 secreted 18 0 secreted secreted Amniota Bilateria Cell.Organisms LRRC16A HGNC:21581 leucine rich repeat containing 16A Q5VZK9 Cytoplasm. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. cytoplasm 87 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms LRRC16B HGNC:20272 leucine rich repeat containing 16B Q8ND23 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms LRRC17 HGNC:16895 leucine rich repeat containing 17 Q8N6Y2 Secreted, extracellular space (By similarity). Endoplasmic reticulum (GO:0005783) 8982252 secreted 84 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Cell.Organisms LRRC18 HGNC:23199 leucine rich repeat containing 18 Q8N456 Cytoplasm (By similarity). cytoplasm 78 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms LRRC19 HGNC:23379 leucine rich repeat containing 19 Q9H756 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 21 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Eukaryota LRRC2 HGNC:14676 leucine rich repeat containing 2 Q9BYS8 Nucleus (GO:0005634) 11896456 plasma membrane 18 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms LRRC20 HGNC:23421 leucine rich repeat containing 20 Q8TCA0 secreted 20 0 secreted secreted Euteleostomi Bilateria Cell.Organisms LRRC23 HGNC:19138 leucine rich repeat containing 23 Q53EV4 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA LRRC24 HGNC:28947 leucine rich repeat containing 24 Q50LG9 Membrane; Single-pass membrane protein (Potential). secreted 18 1 secreted secreted NA NA Cell.Organisms LRRC25 HGNC:29806 leucine rich repeat containing 25 Q8N386 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 38 1 plasma membrane plasma membrane Eutheria Mammalia Mammalia LRRC26 HGNC:31409 leucine rich repeat containing 26 Q2I0M4 Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels (PubMed:15164053). Integral to plasma membrane (GO:0005887) 16585525 secreted 20 1 cytoplasm. plasma membrane multiple Amniota Amniota Holozoa LRRC27 HGNC:29346 leucine rich repeat containing 27 Q9C0I9 plasma membrane 19 0 n/a n/a Eutheria Eutheria Cell.Organisms LRRC28 HGNC:28355 leucine rich repeat containing 28 Q86X40 endoplasmic reticulum membrane 20 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Cell.Organisms LRRC29 HGNC:13605 leucine rich repeat containing 29 Q8WV35 cytoplasm 19 0 cytoplasm cytoplasm Mammalia Bilateria Cell.Organisms LRRC3 HGNC:14965 leucine rich repeat containing 3 Q9BY71 Membrane; Single-pass membrane protein (Potential). secreted 22 1 secreted secreted Euarchontoglires Euteleostomi Holozoa LRRC30 HGNC:30219 leucine rich repeat containing 30 A6NM36 plasma membrane 18 0 n/a n/a Euteleostomi Euteleostomi Cell.Organisms LRRC31 HGNC:26261 leucine rich repeat containing 31 Q6UY01 plasma membrane 15 0 n/a n/a Euteleostomi Eukaryota Cell.Organisms LRRC32 HGNC:4161 leucine rich repeat containing 32 Q14392 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8840187 plasma membrane 22 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms LRRC34 HGNC:28408 leucine rich repeat containing 34 Q8IZ02 nucleus 13 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms LRRC36 HGNC:25615 leucine rich repeat containing 36 Q1X8D7 cytoplasm 24 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota LRRC37A HGNC:29069 leucine rich repeat containing 37A A6NMS7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 20 1 secreted secreted Theria Theria Cell.Organisms LRRC37A2 HGNC:32404 leucine rich repeat containing 37, member A2 A6NM11 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 20 1 secreted secreted NA NA Cell.Organisms LRRC37A3 HGNC:32427 leucine rich repeat containing 37, member A3 O60309 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 24 1 plasma membrane plasma membrane Theria Theria Cell.Organisms LRRC37B HGNC:29070 leucine rich repeat containing 37B Q96QE4 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 21 1 plasma membrane plasma membrane Theria Theria Cell.Organisms LRRC38 HGNC:27005 leucine rich repeat containing 38 Q5VT99 Cell membrane; Single-pass type I membrane protein (By similarity). secreted 21 1 secreted secreted Tetrapoda Euteleostomi Cell.Organisms LRRC39 HGNC:28228 leucine rich repeat containing 39 Q96DD0 plasma membrane 15 0 n/a n/a Euteleostomi Euteleostomi Cell.Organisms LRRC3B HGNC:28105 leucine rich repeat containing 3B Q96PB8 Membrane; Single-pass membrane protein (Potential). secreted 27 1 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LRRC3C HGNC:40034 leucine rich repeat containing 3C A6NJW4 Membrane; Single-pass membrane protein (Potential). secreted 20 1 secreted secreted Theria Theria Cell.Organisms LRRC4 HGNC:15586 leucine rich repeat containing 4 Q9HBW1 Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=LRRC4 and DLG4 are interdependent for synaptic localization (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10964959,10964959 plasma membrane 17 1 plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms LRRC40 HGNC:26004 leucine rich repeat containing 40 Q9H9A6 plasma membrane 19 0 n/a n/a Deuterostomia Eukaryota Cell.Organisms LRRC41 HGNC:16917 leucine rich repeat containing 41 Q15345 Nucleus (GO:0005634) 11384984 cytoplasm 14 2 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi LRRC42 HGNC:28792 leucine rich repeat containing 42 Q9Y546 nucleus 79 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms LRRC43 HGNC:28562 leucine rich repeat containing 43 Q8N309 cytoplasm 19 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota LRRC45 HGNC:28302 leucine rich repeat containing 45 Q96CN5 Nucleus (GO:0005634) 17081983 secreted 17 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms LRRC46 HGNC:25047 leucine rich repeat containing 46 Q96FV0 secreted 26 0 secreted secreted Amniota Eukaryota Cell.Organisms LRRC47 HGNC:29207 leucine rich repeat containing 47 Q8N1G4 Cytoplasm (GO:0005737) 17081983 secreted 22 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms LRRC48 HGNC:25384 leucine rich repeat containing 48 Q9H069 plasma membrane 25 0 n/a n/a Deuterostomia Eukaryota Cell.Organisms LRRC49 HGNC:25965 leucine rich repeat containing 49 Q8IUZ0 Cytoplasm, cytoskeleton. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms LRRC4B HGNC:25042 leucine rich repeat containing 4B Q9NT99 Membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane (By similarity). secreted 18 1 secreted secreted Euteleostomi Bilateria Cell.Organisms LRRC4C HGNC:29317 leucine rich repeat containing 4C Q9HCJ2 Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021); Plasma membrane (GO:0005886) 14595443,15590698 secreted 17 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms LRRC52 HGNC:32156 leucine rich repeat containing 52 Q8N7C0 Cell membrane; Single-pass membrane protein (By similarity). Note=Expression at the cell surface may require the presence of KCNU1. Integral to membrane (GO:0016021) plasma membrane 68 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms LRRC53 HGNC:25255 leucine rich repeat containing 53 A6NM62 Membrane; Single-pass membrane protein (Potential). plasma membrane 17 1 plasma membrane plasma membrane Homininae Mammalia Cell.Organisms LRRC55 HGNC:32324 leucine rich repeat containing 55 Q6ZSA7 Cell membrane; Single-pass membrane protein (By similarity). secreted 16 1 secreted secreted Mammalia Mammalia Cell.Organisms LRRC56 HGNC:25430 leucine rich repeat containing 56 Q8IYG6 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota LRRC57 HGNC:26719 leucine rich repeat containing 57 Q8N9N7 plasma membrane 22 0 n/a n/a Bilateria Eukaryota Cell.Organisms LRRC58 HGNC:26968 leucine rich repeat containing 58 Q96CX6 plasma membrane 22 0 n/a n/a Bilateria Eukaryota Cell.Organisms LRRC59 HGNC:28817 leucine rich repeat containing 59 Q96AG4 Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. Integral to membrane (GO:0016021); Membrane fraction (GO:0005624) ,17215244 plasma membrane 29 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Cell.Organisms LRRC6 HGNC:16725 leucine rich repeat containing 6 Q86X45 Cytoplasm. Cell projection, cilium. cytoplasm 25 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms LRRC61 HGNC:21704 leucine rich repeat containing 61 Q9BV99 plasma membrane 34 0 n/a n/a Deuterostomia Eukaryota Cell.Organisms LRRC63 HGNC:34296 leucine rich repeat containing 63 Q05C16 endoplasmic reticulum membrane 26 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eutheria Cell.Organisms LRRC66 HGNC:34299 leucine rich repeat containing 66 Q68CR7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 22 3 plasma membrane plasma membrane Eutheria Amniota Cell.Organisms LRRC69 HGNC:34303 leucine rich repeat containing 69 Q6ZNQ3 plasma membrane 18 0 n/a n/a Theria Deuterostomia Cell.Organisms LRRC7 HGNC:18531 leucine rich repeat containing 7 Q96NW7 Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Plasma membrane (GO:0005886) 8824323 plasma membrane 13 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms LRRC70 HGNC:35155 leucine rich repeat containing 70 Q7Z2Q7 Membrane; Single-pass membrane protein (Potential). plasma membrane 22 3 plasma membrane plasma membrane Human Amniota Cell.Organisms LRRC71 HGNC:26556 leucine rich repeat containing 71 Q8N4P6 cytoplasm 24 0 cytoplasm cytoplasm Theria Deuterostomia Cell.Organisms LRRC72 HGNC:42972 leucine rich repeat containing 72 A6NJI9 nucleus 19 0 nucleus nucleus Homininae Eukaryota Eukaryota LRRC73 HGNC:21375 leucine rich repeat containing 73 Q5JTD7 cytoplasm 17 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms LRRC74 HGNC:23346 leucine rich repeat containing 74 Q0VAA2 plasma membrane 14 1 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms LRRC75A HGNC:32403 leucine rich repeat containing 75A Q8NAA5 nucleus 84 0 nucleus nucleus Tetrapoda Euteleostomi Chordata LRRC75B HGNC:33155 leucine rich repeat containing 75B Q2VPJ9 nucleus 69 0 nucleus nucleus Tetrapoda Euteleostomi Craniata LRRC8A HGNC:19027 leucine rich repeat containing 8 family, member A Q8IWT6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 15094057 endoplasmic reticulum membrane 48 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Cell.Organisms LRRC8B HGNC:30692 leucine rich repeat containing 8 family, member B Q6P9F7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 15094057 endoplasmic reticulum membrane 39 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Cell.Organisms LRRC8C HGNC:25075 leucine rich repeat containing 8 family, member C Q8TDW0 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 15184384 endoplasmic reticulum membrane 97 5 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Cell.Organisms LRRC8D HGNC:16992 leucine rich repeat containing 8 family, member D Q7L1W4 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 15094057 endoplasmic reticulum membrane 40 5 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms LRRC8E HGNC:26272 leucine rich repeat containing 8 family, member E Q6NSJ5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 53 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Cell.Organisms LRRCC1 HGNC:29373 leucine rich repeat and coiled-coil centrosomal protein 1 Q9C099 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Associates with the centrosome throughout the cell cycle and extensively accumulates during the mitotic phase. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms LRRD1 HGNC:34300 leucine-rich repeats and death domain containing 1 A4D1F6 cytoplasm 17 0 cytoplasm cytoplasm NA NA Cell.Organisms LRRFIP1 HGNC:6702 leucine rich repeat (in FLII) interacting protein 1 Q32MZ4 Nucleus. Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10366446,9671805,14522076,9671805,14522076,9705290 cytoplasm 12 0 cytoplasm. nucleus multiple Homininae Theria Metazoa LRRFIP2 HGNC:6703 leucine rich repeat (in FLII) interacting protein 2 Q9Y608 Nucleus (GO:0005634) 17081983 cytoplasm 16 0 nucleus nucleus Eutheria Bilateria Cell.Organisms LRRIQ1 HGNC:25708 leucine-rich repeats and IQ motif containing 1 Q96JM4 plasma membrane 17 0 n/a n/a Deuterostomia Eukaryota Cell.Organisms LRRIQ3 HGNC:28318 leucine-rich repeats and IQ motif containing 3 A6PVS8 cytoplasm 23 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms LRRIQ4 HGNC:34298 leucine-rich repeats and IQ motif containing 4 A6NIV6 plasma membrane 12 0 n/a n/a Tetrapoda Tetrapoda Cell.Organisms LRRK1 HGNC:18608 leucine-rich repeat kinase 1 Q38SD2 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms LRRK2 HGNC:18618 leucine-rich repeat kinase 2 Q5S007 Cytoplasm. Membrane; Peripheral membrane protein. Mitochondrion. Note=Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane. plasma membrane 13 0 cytoplasm. mitochondrion multiple Deuterostomia Deuterostomia Cell.Organisms LRRN1 HGNC:20980 leucine rich repeat neuronal 1 Q6UXK5 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 12 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms LRRN2 HGNC:16914 leucine rich repeat neuronal 2 O75325 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 18 1 secreted secreted Euteleostomi Bilateria Cell.Organisms LRRN3 HGNC:17200 leucine rich repeat neuronal 3 Q9H3W5 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 11 1 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms LRRN4 HGNC:16208 leucine rich repeat neuronal 4 Q8WUT4 Membrane; Single-pass type I membrane protein (Potential). secreted 20 1 secreted secreted Tetrapoda Tetrapoda Opisthokonta LRRN4CL HGNC:33724 LRRN4 C-terminal like Q8ND94 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 77 1 plasma membrane plasma membrane Mammalia Tetrapoda Craniata LRRTM1 HGNC:19408 leucine rich repeat transmembrane neuronal 1 Q86UE6 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 17 1 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms LRRTM2 HGNC:19409 leucine rich repeat transmembrane neuronal 2 O43300 Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized to excitatory synapses (By similarity). Integral to membrane (GO:0016021) 12676565 secreted 16 1 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms LRRTM3 HGNC:19410 leucine rich repeat transmembrane neuronal 3 Q86VH5 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 23 1 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms LRRTM4 HGNC:19411 leucine rich repeat transmembrane neuronal 4 Q86VH4 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) 12676565 secreted 19 1 secreted secreted Amniota Euteleostomi Cell.Organisms LRSAM1 HGNC:25135 leucine rich repeat and sterile alpha motif containing 1 Q6UWE0 Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15256501,14635195,14635195 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms LRTM1 HGNC:25023 leucine-rich repeats and transmembrane domains 1 Q9HBL6 Membrane; Single-pass type I membrane protein (Potential). secreted 18 1 secreted secreted Mammalia Euteleostomi Cell.Organisms LRTM2 HGNC:32443 leucine-rich repeats and transmembrane domains 2 Q8N967 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 21 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms LRTOMT HGNC:25033 leucine rich transmembrane and O-methyltransferase domain containing Q8WZ04 Isoform 1: Membrane; Single-pass membrane protein (Potential). Isoform 2: Cytoplasm (By similarity). cytoplasm 91 2 cytoplasm cytoplasm Human Euteleostomi Cell.Organisms LRWD1 HGNC:21769 leucine-rich repeats and WD repeat domain containing 1 Q9UFC0 Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Nucleus (GO:0005634) 17081983 secreted 37 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms LSAMP HGNC:6705 limbic system-associated membrane protein Q13449 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 8666243 plasma membrane 15 0 n/a n/a Tetrapoda Bilateria Cell.Organisms LSG1 HGNC:25652 large 60S subunit nuclear export GTPase 1 Q9H089 Cytoplasm. Endoplasmic reticulum. Nucleus, Cajal body. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum. Nucleolus (GO:0005730); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 16209721,16209721,16209721 cytoplasm 26 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Cell.Organisms LSM1 HGNC:20472 LSM1, U6 small nuclear RNA associated O15116 Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10523320,10523320 nucleus 21 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms LSM10 HGNC:17562 LSM10, U7 small nuclear RNA associated Q969L4 Nucleus. Nucleus (GO:0005634) 11574479 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota LSM11 HGNC:30860 LSM11, U7 small nuclear RNA associated P83369 Nucleus. Nucleus (GO:0005634) 12975319 nucleus 100 0 nucleus nucleus Chordata Eukaryota Holozoa LSM12 HGNC:26407 LSM12 homolog (S. cerevisiae) Q3MHD2 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota LSM14A HGNC:24489 LSM14A, SCD6 homolog A (S. cerevisiae) Q8ND56 Cytoplasm. Cytoplasm, P-body. Note=Targeted to stress granules (SGs) in response to cellular stress. cytoplasm 100 0 cytoplasm cytoplasm NA NA NA LSM14B HGNC:15887 LSM14B, SCD6 homolog B (S. cerevisiae) Q9BX40 cytoplasm 50 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Eukaryota LSM2 HGNC:13940 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) Q9Y333 Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10523320,10523320 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA LSM3 HGNC:17874 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) P62310 Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10523320,10523320 nucleus 20 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms LSM4 HGNC:17259 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) Q9Y4Z0 Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10523320,10523320 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms LSM5 HGNC:17162 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) Q9Y4Y9 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10523320,10523320 nucleus 48 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms LSM6 HGNC:17017 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) P62312 Cytoplasm. Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10523320,10523320 nucleus 37 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms LSM7 HGNC:20470 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) Q9UK45 Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10523320,10523320 nucleus 33 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms LSM8 HGNC:20471 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) O95777 Nucleus (Potential). nucleus 28 0 nucleus nucleus NA NA Cell.Organisms LSMEM1 HGNC:22036 leucine-rich single-pass membrane protein 1 Q8N8F7 Membrane; Single-pass membrane protein (Potential). secreted 16 1 secreted secreted Theria Amniota Amniota LSMEM2 HGNC:26781 leucine-rich single-pass membrane protein 2 Q8N112 Membrane; Single-pass membrane protein (Potential). secreted 93 2 n/a n/a Mammalia Mammalia Mammalia LSP1 HGNC:6707 lymphocyte-specific protein 1 P33241 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9890705,2674678,8838798,9890705,8838798 cytoplasm 20 0 cytoplasm cytoplasm Eutheria Tetrapoda Euteleostomi LSR HGNC:29572 lipolysis stimulated lipoprotein receptor Q86X29 Cell membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10224102 secreted 69 1 plasma membrane plasma membrane Theria Euteleostomi Craniata LSS HGNC:6708 lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) P48449 Endoplasmic reticulum membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 3515096,15598749 cytoplasm 9 0 endoplasmic reticulum. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms LST1 HGNC:14189 leukocyte specific transcript 1 O00453 Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Note=Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm. Plasma membrane (GO:0005886) 10706707 secreted 64 1 endomembrane system. golgi apparatus membrane. plasma membrane multiple Euarchontoglires Eutheria NA LTA HGNC:6709 lymphotoxin alpha P01374 Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9307242,7995952,7995952,11823516,11823516 secreted 47 0 cytoplasm. secreted multiple NA NA NA LTA4H HGNC:6710 leukotriene A4 hydrolase P09960 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1881903,10887124,11451962 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms LTB HGNC:6711 lymphotoxin beta (TNF superfamily, member 3) Q06643 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7995952,7916655,11823516,15034048,12474234,11823516 secreted 60 1 cytoplasm. plasma membrane multiple Mammalia Tetrapoda NA LTB4R HGNC:6713 leukotriene B4 receptor Q15722 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9177352 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa LTB4R2 HGNC:19260 leukotriene B4 receptor 2 Q9NPC1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 10934230,10889186 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Craniata LTBP1 HGNC:6714 latent transforming growth factor beta binding protein 1 Q14766 Secreted. Extracellular (GO:0005576);Extracellular (GO:0005576) 8537398/8537398,10646116,9274625 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LTBP2 HGNC:6715 latent transforming growth factor beta binding protein 2 Q14767 Secreted (By similarity). Note=Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers (By similarity). Extracellular (GO:0005576) 7798248 secreted 81 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LTBP3 HGNC:6716 latent transforming growth factor beta binding protein 3 Q9NS15 Secreted (By similarity). Note=Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide (By similarity). Extracellular (GO:0005576) 12062452 secreted 89 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LTBP4 HGNC:6717 latent transforming growth factor beta binding protein 4 Q8N2S1 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11683420 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms LTBR HGNC:6718 lymphotoxin beta receptor (TNFR superfamily, member 3) P36941 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8171323 secreted 19 1 plasma membrane plasma membrane Theria Theria Holozoa LTC4S HGNC:6719 leukotriene C4 synthase Q16873 Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Integral to membrane (GO:0016021); Microsome (GO:0005792);Integral to membrane (GO:0016021); Perinuclear region (GO:0048471); Microsome (GO:0005792) 1517222,11034337,11034337,7599836,7663172/10591082,8052639,10436863,8052639 endoplasmic reticulum membrane 26 2 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus. nucleus membrane. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms LTF HGNC:6720 lactotransferrin P02788 Isoform 1: Secreted. Cytoplasmic granule. Isoform DeltaLf: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm. Secretory granule (GO:0030141); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634) 3028636,3028636,3028636,11730482,10944471,1661314,2049066,16188874,7744878,11730482 secreted 54 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota LTK HGNC:6721 leukocyte receptor tyrosine kinase P29376 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 8910363,8995435 plasma membrane 46 1 endoplasmic reticulum. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms LTN1 HGNC:13082 listerin E3 ubiquitin protein ligase 1 O94822 nucleus 17 1 nucleus nucleus Eukaryota Eukaryota Eukaryota LTV1 HGNC:21173 LTV1 ribosome biogenesis factor Q96GA3 Cytoplasm (GO:0005737) 17081983 nucleus 93 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota LUC7L HGNC:6723 LUC7-like (S. cerevisiae) Q9NQ29 Nucleus (GO:0005634) 17081983 nucleus 83 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota LUC7L2 HGNC:21608 LUC7-like 2 (S. cerevisiae) Q9Y383 Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity). Note=Colocalizes with SCNM1 and SNRNP70 in nuclear speckles (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,17081983,17081983 nucleus 99 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota NA LUC7L3 HGNC:24309 LUC7-like 3 (S. cerevisiae) O95232 Nucleus speckle. Note=The subnuclear localization is affected by cisplatin. Nucleus (GO:0005634) 10631324,12565863 nucleus 100 0 nucleus nucleus Human Eukaryota Eukaryota LUM HGNC:6724 lumican P51884 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 7665616,16188874 secreted 40 0 secreted secreted Euteleostomi Opisthokonta Cell.Organisms LURAP1 HGNC:32327 leucine rich adaptor protein 1 Q96LR2 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata LURAP1L HGNC:31452 leucine rich adaptor protein 1-like Q8IV03 cytoplasm 37 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata LUZP1 HGNC:14985 leucine zipper protein 1 Q86V48 Nucleus. Note=Also detected in soma and dendrites of neurons (By similarity). Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 8812416,17081983,15561729,17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Euteleostomi Craniata LUZP2 HGNC:23206 leucine zipper protein 2 Q86TE4 Secreted (Potential). cytoplasm 16 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Chordata LUZP4 HGNC:24971 leucine zipper protein 4 Q9P127 Nucleus. Note=In nuclear speckles. Nucleus (GO:0005634) 12032826 nucleus 100 0 nucleus nucleus Catarrhini Eutheria NA LUZP6 HGNC:33955 leucine zipper protein 6 Q538Z0 mitochondrion 14 0 mitochondrion mitochondrion NA NA NA LXN HGNC:13347 latexin Q9BS40 Cytoplasm (Probable). secreted 16 0 cytoplasm cytoplasm Amniota Euteleostomi Craniata LY6D HGNC:13348 lymphocyte antigen 6 complex, locus D Q14210 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 7790363 secreted 51 1 plasma membrane plasma membrane Theria Theria Eutheria LY6E HGNC:6727 lymphocyte antigen 6 complex, locus E Q16553 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886) 11784869 secreted 57 1 plasma membrane plasma membrane Eutheria Amniota Tetrapoda LY6G5B HGNC:13931 lymphocyte antigen 6 complex, locus G5B Q8NDX9 Secreted (Potential). Plasma membrane (GO:0005886) secreted 71 0 secreted secreted NA NA NA LY6G5C HGNC:13932 lymphocyte antigen 6 complex, locus G5C Q5SRR4 Secreted (Potential). Integral to membrane (GO:0016021) secreted 83 1 secreted secreted Eutheria Eutheria NA LY6G6C HGNC:13936 lymphocyte antigen 6 complex, locus G6C O95867 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 10384126 secreted 22 1 plasma membrane plasma membrane Theria Theria NA LY6G6D HGNC:13935 lymphocyte antigen 6 complex, locus G6D O95868 Cell membrane; Lipid-anchor, GPI-anchor. Cell projection, filopodium. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10384126,12079290 secreted 87 1 plasma membrane. secreted multiple Human Eutheria NA LY6G6F HGNC:13933 lymphocyte antigen 6 complex, locus G6F Q5SQ64 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Mammalia Mammalia NA LY6H HGNC:6728 lymphocyte antigen 6 complex, locus H O94772 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886) 9799603 secreted 75 0 secreted secreted Eutheria Eutheria Eutheria LY6K HGNC:24225 lymphocyte antigen 6 complex, locus K Q17RY6 Secreted. Cytoplasm. Cell membrane; Lipid- anchor, GPI-anchor (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,17081983 secreted 92 1 cytoplasm. secreted multiple Catarrhini Eutheria NA LY75 HGNC:6729 lymphocyte antigen 75 O60449 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 9553150,9862343 secreted 23 3 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms LY86 HGNC:16837 lymphocyte antigen 86 O95711 Secreted, extracellular space. Note=Associated with CD180 at the cell surface. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9763566,9686597 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi LY9 HGNC:6730 lymphocyte antigen 9 Q9HBG7 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12621057,11369645 plasma membrane 14 2 plasma membrane plasma membrane Eutheria Tetrapoda Euteleostomi LY96 HGNC:17156 lymphocyte antigen 96 Q9Y6Y9 Secreted, extracellular space. Extracellular (GO:0005576) 11976338 secreted 100 0 secreted secreted Theria Amniota Amniota LYAR HGNC:26021 Ly1 antibody reactive Q9NX58 Nucleus, nucleolus. Nucleolus (GO:0005730) 8491376,11790298 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota LYG1 HGNC:27014 lysozyme G-like 1 Q8N1E2 Secreted (Probable). secreted 34 0 secreted secreted Human Eutheria Cell.Organisms LYG2 HGNC:29615 lysozyme G-like 2 Q86SG7 Secreted (Probable). secreted 39 0 secreted secreted Chordata Chordata Cell.Organisms LYL1 HGNC:6734 lymphoblastic leukemia associated hematopoiesis regulator 1 P12980 Nucleus (Potential). Nucleus (GO:0005634) 2752424 nucleus 51 0 nucleus nucleus Mammalia Euteleostomi Metazoa LYN HGNC:6735 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog P07948 Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9202419,9202419,8705993,17081983 cytoplasm 30 0 cytoplasm. golgi apparatus. nucleus multiple NA NA Cell.Organisms LYNX1 HGNC:29604 Ly6/neurotoxin 1 Q9BZG9 Isoform 1: Secreted (Potential). Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor (Potential). Cell projection, dendrite (By similarity). Isoform 3: Secreted. secreted 90 0 secreted secreted Euarchontoglires Mammalia Mammalia LYPD1 HGNC:28431 LY6/PLAUR domain containing 1 Q8N2G4 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 85 0 secreted secreted Theria Euteleostomi Chordata LYPD2 HGNC:25215 LY6/PLAUR domain containing 2 Q6UXB3 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 30 0 secreted secreted Amniota Amniota Tetrapoda LYPD3 HGNC:24880 LY6/PLAUR domain containing 3 O95274 Cell membrane; Lipid-anchor, GPI-anchor. secreted 79 1 secreted secreted Eutheria Mammalia Amniota LYPD4 HGNC:28659 LY6/PLAUR domain containing 4 Q6UWN0 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 90 0 secreted secreted Euarchontoglires Eutheria Mammalia LYPD5 HGNC:26397 LY6/PLAUR domain containing 5 Q6UWN5 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 95 1 secreted secreted Theria Theria Amniota LYPD6 HGNC:28751 LY6/PLAUR domain containing 6 Q86Y78 Secreted (Probable). secreted 88 0 secreted secreted Euarchontoglires Euteleostomi Bilateria LYPD6B HGNC:27018 LY6/PLAUR domain containing 6B Q8NI32 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 90 0 secreted secreted Amniota Euteleostomi Bilateria LYPD8 HGNC:44208 LY6/PLAUR domain containing 8 Q6UX82 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 4 1 secreted secreted NA NA NA LYPLA1 HGNC:6737 lysophospholipase I O75608 Cytoplasm (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 10760470,10760470 cytoplasm 90 0 endoplasmic reticulum. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms LYPLA2 HGNC:6738 lysophospholipase II O95372 Cytoplasm (Probable). cytoplasm 57 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms LYPLAL1 HGNC:20440 lysophospholipase-like 1 Q5VWZ2 Cytoplasm (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms LYRM1 HGNC:25074 LYR motif containing 1 O43325 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota LYRM2 HGNC:25229 LYR motif containing 2 Q9NU23 mitochondrion 85 0 mitochondrion mitochondrion Tetrapoda Bilateria Eumetazoa LYRM4 HGNC:21365 LYR motif containing 4 Q9HD34 Mitochondrion. Nucleus. mitochondrion 27 0 mitochondrion. nucleus multiple Euarchontoglires Eukaryota Eukaryota LYRM5 HGNC:27052 LYR motif containing 5 Q6IPR1 mitochondrion 64 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota LYRM7 HGNC:28072 LYR motif containing 7 Q5U5X0 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Theria Eukaryota Eukaryota LYRM9 HGNC:27314 LYR motif containing 9 A8MSI8 mitochondrion 54 0 mitochondrion mitochondrion NA NA Metazoa LYSMD1 HGNC:32070 LysM, putative peptidoglycan-binding, domain containing 1 Q96S90 cytoplasm 14 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota LYSMD2 HGNC:28571 LysM, putative peptidoglycan-binding, domain containing 2 Q8IV50 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms LYSMD3 HGNC:26969 LysM, putative peptidoglycan-binding, domain containing 3 Q7Z3D4 Membrane; Single-pass membrane protein (Potential). plasma membrane 45 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa LYSMD4 HGNC:26571 LysM, putative peptidoglycan-binding, domain containing 4 Q5XG99 Membrane; Single-pass membrane protein (Potential). plasma membrane 45 1 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa LYST HGNC:1968 lysosomal trafficking regulator Q99698 Cytoplasm (Potential). Lysosome (GO:0005764); Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737) 11102458,9606205,12753649 endoplasmic reticulum 19 0 cytoplasm. lysosome multiple Deuterostomia Eukaryota Cell.Organisms LYVE1 HGNC:14687 lymphatic vessel endothelial hyaluronan receptor 1 Q9Y5Y7 Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Plasma membrane (GO:0005886) 10037799 secreted 22 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa LYZ HGNC:6740 lysozyme P61626 Secreted. Extracellular (GO:0005576) 9659355,5168859 secreted 100 0 secreted secreted Tetrapoda Bilateria Bilateria LYZL1 HGNC:30502 lysozyme-like 1 Q6UWQ5 Secreted (Probable). secreted 44 0 secreted secreted Eutheria Bilateria Bilateria LYZL2 HGNC:29613 lysozyme-like 2 Q7Z4W2 Secreted (Probable). Lysosome (GO:0005764) secreted 46 0 secreted secreted Eutheria Bilateria Bilateria LYZL4 HGNC:28387 lysozyme-like 4 Q96KX0 Secreted (Probable). Extracellular (GO:0005576) secreted 32 0 secreted secreted Euarchontoglires Mammalia Holozoa LYZL6 HGNC:29614 lysozyme-like 6 O75951 Secreted (Probable). secreted 36 0 secreted secreted Eutheria Mammalia Bilateria LZIC HGNC:17497 leucine zipper and CTNNBIP1 domain containing Q8WZA0 cytoplasm 46 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota LZTFL1 HGNC:6741 leucine zipper transcription factor-like 1 Q9NQ48 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota LZTR1 HGNC:6742 leucine-zipper-like transcription regulator 1 Q8N653 Nucleus (GO:0005634) nucleus 16 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms LZTS1 HGNC:13861 leucine zipper, putative tumor suppressor 1 Q9Y250 Cytoplasm (By similarity). Cell membrane (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). Cytoplasm (GO:0005737) 11504921 cytoplasm 27 0 cytoplasm cytoplasm Human Euteleostomi Bilateria LZTS2 HGNC:29381 leucine zipper, putative tumor suppressor 2 Q9BRK4 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria M1AP HGNC:25183 meiosis 1 associated protein Q8TC57 Cytoplasm (By similarity). cytoplasm 65 0 cytoplasm cytoplasm Amniota Chordata Holozoa M6PR HGNC:6752 mannose-6-phosphate receptor (cation dependent) P20645 Lysosome membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Cytoplasmic vesicle (GO:0016023) 8099077,8099077,8099077,8099077 secreted 93 1 endosome. golgi apparatus. lysosome membrane. plasma membrane multiple Deuterostomia Opisthokonta Opisthokonta MAATS1 HGNC:24010 MYCBP-associated, testis expressed 1 Q7Z4T9 Cytoplasm. Mitochondrion. Note=Isoform 4 is found in the mitochondria and localized in the neck of the sperm. Mitochondrion (GO:0005739) 12223483 cytoplasm 7 0 cytoplasm. mitochondrion multiple Deuterostomia Eukaryota Eukaryota MAB21L1 HGNC:6757 mab-21-like 1 (C. elegans) Q13394 Nucleus (By similarity). Nucleus (GO:0005634) 10556287 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eumetazoa MAB21L2 HGNC:6758 mab-21-like 2 (C. elegans) Q9Y586 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10556287,10556287 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eumetazoa MAB21L3 HGNC:26787 mab-21-like 3 (C. elegans) Q8N8X9 nucleus 12 0 nucleus nucleus Amniota Amniota Eumetazoa MACC1 HGNC:30215 metastasis associated in colon cancer 1 Q6ZN28 Cytoplasm. Nucleus. Note=Mainly found in the cytoplasm in non-metastasizing tumors. nucleus 48 0 cytoplasm. nucleus multiple Chordata Chordata Chordata MACF1 HGNC:13664 microtubule-actin crosslinking factor 1 Q9UPN3 Isoform 2: Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane. Isoform 1: Cytoplasm. Golgi apparatus. Note=Localizes to the tips of microtubules. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794);Cytoplasm (GO:0005737); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 17081983,17081983/10559237,14636561,15265687/10559237,14636561,15561729,15598749 cytoplasm 31 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota MACROD1 HGNC:29598 MACRO domain containing 1 Q9BQ69 Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. Mitochondrion (GO:0005739) 15598749 nucleus 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MACROD2 HGNC:16126 MACRO domain containing 2 A1Z1Q3 Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. nucleus 100 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms MAD1L1 HGNC:6762 MAD1 mitotic arrest deficient-like 1 (yeast) Q9Y6D9 Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Co-localizes with NEK2 at the kinetochore. Kinetochore (GO:0000776); Nucleus (GO:0005634); Centrosome (GO:0005813) 12351790,9546394,15824131,17363900,15561729,9546394,9546394 nucleus 16 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota MAD2L1 HGNC:6763 MAD2 mitotic arrest deficient-like 1 (yeast) Q13257 Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. Kinetochore (GO:0000776); Nucleus (GO:0005634); Chromosome (GO:0005694); Cytoplasm (GO:0005737) 15824131,17363900,16732327,17093495,15561729,13678590,12640463,11181178,11129339,9637688 nucleus 32 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MAD2L1BP HGNC:21059 MAD2L1 binding protein Q15013 Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle. Nucleus (GO:0005634) 12456649 nucleus 24 0 cytoplasm. nucleus multiple Amniota Deuterostomia Eumetazoa MAD2L2 HGNC:6764 MAD2 mitotic arrest deficient-like 2 (yeast) Q9UI95 Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11717438,11717438 nucleus 15 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota MADCAM1 HGNC:6765 mucosal vascular addressin cell adhesion molecule 1 Q13477 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9162097,8502297 nucleus 38 1 plasma membrane plasma membrane Theria Theria Amniota MADD HGNC:6766 MAP-kinase activating death domain Q8WXG6 Membrane. Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8988362,8988362 golgi apparatus 14 4 cytoplasm. plasma membrane multiple Bilateria Bilateria Eukaryota MAEA HGNC:13731 macrophage erythroblast attacher Q7L5Y9 Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern. Plasma membrane (GO:0005886) 9763581 nucleus 12 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MAEL HGNC:25929 maelstrom spermatogenic transposon silencer Q96JY0 Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). Nucleus (GO:0005634) nucleus 64 0 cytoplasm. nucleus multiple Amniota Bilateria Metazoa MAF HGNC:6776 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog O75444 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9616139,12939343,14688382,16023139,12939343,14688382 nucleus 99 0 cytoplasm. nucleus multiple Homininae Euteleostomi Metazoa MAF1 HGNC:24966 MAF1 homolog (S. cerevisiae) Q9H063 Nucleus. Cytoplasm. Nucleus (GO:0005634) 17081983 nucleus 55 0 cytoplasm. nucleus multiple Mammalia Eukaryota Eukaryota MAFA HGNC:23145 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A Q8NHW3 Nucleus. Note=Detected in nuclei of pancreas islet beta cells (By similarity). Nucleus (GO:0005634) 12011435,12368292,12917329,16023139 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa MAFB HGNC:6408 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B Q9Y5Q3 Nucleus (By similarity). Nucleus (GO:0005634) 16023139 nucleus 97 0 nucleus nucleus Euteleostomi Bilateria Metazoa MAFF HGNC:6780 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F Q9ULX9 Nucleus. Nucleus (GO:0005634) 10527846 nucleus 100 0 nucleus nucleus Theria Amniota Metazoa MAFG HGNC:6781 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G O15525 Nucleus. Nucleus (GO:0005634) 12496124 nucleus 100 0 nucleus nucleus Chordata Bilateria Metazoa MAFK HGNC:6782 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K O60675 Nucleus. Nucleus (GO:0005634) 9150357,8887638 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa MAG HGNC:6783 myelin associated glycoprotein P20916 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 6177705,2447011 secreted 20 1 plasma membrane plasma membrane Theria Euteleostomi Metazoa MAGEA1 HGNC:6796 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) P43355 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7927954,7627949 nucleus 61 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Eukaryota MAGEA10 HGNC:6797 melanoma antigen family A, 10 P43363 Nucleus. Nucleus (GO:0005634) 10446460 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota MAGEA11 HGNC:6798 melanoma antigen family A, 11 P43364 Nucleus. Cytoplasm. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9495246/15684378,15684378 nucleus 48 0 cytoplasm. nucleus multiple Catarrhini Catarrhini NA MAGEA12 HGNC:6799 melanoma antigen family A, 12 P43365 nucleus 85 0 nucleus nucleus Catarrhini Catarrhini NA MAGEA2 HGNC:6800 melanoma antigen family A, 2 P43356 Nucleus. Nucleus, PML body. nucleus 100 0 nucleus nucleus Homininae Homininae Opisthokonta MAGEA2B HGNC:19340 melanoma antigen family A, 2B P43356 Nucleus. Nucleus, PML body. nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Opisthokonta MAGEA3 HGNC:6801 melanoma antigen family A, 3 P43357 Cytoplasm (GO:0005737) 7757970 nucleus 80 0 cytoplasm cytoplasm NA NA Opisthokonta MAGEA4 HGNC:6802 melanoma antigen family A, 4 P43358 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12759544,12759544 nucleus 60 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Eukaryota MAGEA5 HGNC:6803 melanoma antigen family A, 5 P43359 nucleus 61 0 nucleus nucleus NA NA NA MAGEA6 HGNC:6804 melanoma antigen family A, 6 P43360 nucleus 80 0 nucleus nucleus Catarrhini Catarrhini NA MAGEA8 HGNC:6806 melanoma antigen family A, 8 P43361 nucleus 55 0 nucleus nucleus Catarrhini Catarrhini NA MAGEA9 HGNC:6807 melanoma antigen family A, 9 P43362 nucleus 50 0 nucleus nucleus Catarrhini Catarrhini NA MAGEA9B HGNC:31909 melanoma antigen family A, 9B P43362 nucleus 50 0 nucleus nucleus Catarrhini Catarrhini NA MAGEB1 HGNC:6808 melanoma antigen family B, 1 P43366 nucleus 34 0 nucleus nucleus Human Eutheria Eukaryota MAGEB10 HGNC:25377 melanoma antigen family B, 10 Q96LZ2 nucleus 35 0 nucleus nucleus Catarrhini Eutheria Eukaryota MAGEB16 HGNC:21188 melanoma antigen family B, 16 A2A368 nucleus 38 0 nucleus nucleus Eutheria Eutheria Eukaryota MAGEB17 HGNC:17418 melanoma antigen family B, 17 A8MXT2 nucleus 31 1 nucleus nucleus Catarrhini Catarrhini Eukaryota MAGEB18 HGNC:28515 melanoma antigen family B, 18 Q96M61 nucleus 32 0 nucleus nucleus Eutheria Eutheria Eukaryota MAGEB2 HGNC:6809 melanoma antigen family B, 2 O15479 Nucleus (GO:0005634) 11211869 nucleus 27 0 nucleus nucleus Catarrhini Catarrhini Eukaryota MAGEB3 HGNC:6810 melanoma antigen family B, 3 O15480 nucleus 30 0 nucleus nucleus Eutheria Eutheria Eukaryota MAGEB4 HGNC:6811 melanoma antigen family B, 4 O15481 nucleus 36 0 nucleus nucleus Eutheria Eutheria Eukaryota MAGEB5 HGNC:23795 melanoma antigen family B, 5 Q9BZ81 nucleus 33 0 nucleus nucleus Human Eutheria Metazoa MAGEB6 HGNC:23796 melanoma antigen family B, 6 Q8N7X4 nucleus 25 0 nucleus nucleus Homininae Homininae Opisthokonta MAGEC1 HGNC:6812 melanoma antigen family C, 1 O60732 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12115486,17137291,12115486 nucleus 34 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Metazoa MAGEC2 HGNC:13574 melanoma antigen family C, 2 Q9UBF1 Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12920247,12920247 nucleus 35 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Metazoa MAGEC3 HGNC:23798 melanoma antigen family C, 3 Q8TD91 nucleus 41 0 nucleus nucleus Catarrhini Catarrhini Eukaryota MAGED1 HGNC:6813 melanoma antigen family D, 1 Q9Y5V3 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10985348,12754255,12754255,10985348,12754255,10985348 nucleus 22 1 cytoplasm. nucleus. plasma membrane multiple Euarchontoglires Eutheria NA MAGED2 HGNC:16353 melanoma antigen family D, 2 Q9UNF1 Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/11856887,17081983,17081983 nucleus 23 0 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota MAGED4 HGNC:23793 melanoma antigen family D, 4 Q96JG8 Cell surface (GO:0009986) 11602350 nucleus 20 1 nucleus nucleus Catarrhini Eutheria Eukaryota MAGED4B HGNC:22880 melanoma antigen family D, 4B Q96JG8 Nucleus (GO:0005634) nucleus 20 1 nucleus nucleus Catarrhini Eutheria NA MAGEE1 HGNC:24934 melanoma antigen family E, 1 Q9HCI5 Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). Cell membrane (By similarity). Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, co-localizes with DTNA in the Schwann cell membrane (By similarity). Nucleus (GO:0005634) 14623885 secreted 22 0 nucleus nucleus Euarchontoglires Euarchontoglires NA MAGEE2 HGNC:24935 melanoma antigen family E, 2 Q8TD90 nucleus 17 0 nucleus nucleus Eutheria Eutheria Metazoa MAGEF1 HGNC:29639 melanoma antigen family F, 1 Q9HAY2 nucleus 21 0 nucleus nucleus Catarrhini Eutheria Metazoa MAGEH1 HGNC:24092 melanoma antigen family H, 1 Q9H213 Cytoplasm (GO:0005737) 12414813 nucleus 22 1 cytoplasm cytoplasm Eutheria Eutheria Holozoa MAGEL2 HGNC:6814 MAGE-like 2 Q9UJ55 nucleus 22 1 nucleus nucleus NA NA Eukaryota MAGI1 HGNC:946 membrane associated guanylate kinase, WW and PDZ domain containing 1 Q96QZ7 Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions. Plasma membrane (GO:0005886) 9647739 nucleus 39 0 nucleus nucleus Bilateria Bilateria Cell.Organisms MAGI2 HGNC:18957 membrane associated guanylate kinase, WW and PDZ domain containing 2 Q86UL8 Cell junction, synapse, synaptosome (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Membrane-associated in synaptosomes (By similarity). Cytoplasm (GO:0005737) 10681527 cytoplasm 29 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAGI3 HGNC:29647 membrane associated guanylate kinase, WW and PDZ domain containing 3 Q5TCQ9 Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus (By similarity). Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10748157,12615970,11969287,16316992,12615970,16316992 nucleus 44 0 nucleus nucleus Bilateria Bilateria Cell.Organisms MAGIX HGNC:30006 MAGI family member, X-linked Q9H6Y5 Nucleus (GO:0005634) cytoplasm 24 0 cytoplasm cytoplasm Euarchontoglires Eutheria Holozoa MAGOH HGNC:6815 mago-nashi homolog, proliferation-associated (Drosophila) P61326 Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12781131,11707413,12781131,11707413 cytoplasm 24 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MAGOHB HGNC:25504 mago-nashi homolog B (Drosophila) Q96A72 Nucleus (By similarity). Nucleus (GO:0005634) 15561729 cytoplasm 25 1 nucleus nucleus Eukaryota Eukaryota Eukaryota MAGT1 HGNC:28880 magnesium transporter 1 Q9H0U3 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). nucleus 11 4 plasma membrane plasma membrane Opisthokonta Eukaryota NA MAK HGNC:6816 male germ cell-associated kinase P20794 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment (By similarity). Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. Nucleus (GO:0005634) 12084720 cytoplasm 48 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms MAK16 HGNC:13703 MAK16 homolog (S. cerevisiae) Q9BXY0 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,11790298,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MAL HGNC:6817 mal, T-cell differentiation protein P21145 Membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739); Golgi vesicle (GO:0005798); Endosome (GO:0005768);Endoplasmic reticulum (GO:0005783) 8132541,9003426,9168919,10512878,9168919,10512878,10366425,9003426,9003426/8132541 endoplasmic reticulum membrane 49 4 endoplasmic reticulum. endosome. golgi apparatus. mitochondrion. plasma membrane multiple Euteleostomi Euteleostomi Craniata MAL2 HGNC:13634 mal, T-cell differentiation protein 2 (gene/pseudogene) Q969L2 Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non- polarized Hep-G2 cells, distributed to the perinuclear region. Endosome (GO:0005768); Cytoplasm (GO:0005737) 12370246,,17145811, endoplasmic reticulum membrane 54 4 cytoplasm. endosome. plasma membrane multiple Tetrapoda Euteleostomi NA MALL HGNC:6818 mal, T-cell differentiation protein-like Q13021 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 11294831,11294831 endoplasmic reticulum membrane 66 4 plasma membrane plasma membrane Amniota Amniota Chordata MALRD1 HGNC:24331 MAM and LDL receptor class A domain containing 1 Q5VYJ5 Membrane; Single-pass membrane protein (Potential). secreted 31 1 secreted secreted Deuterostomia Deuterostomia Cell.Organisms MALSU1 HGNC:21721 mitochondrial assembly of ribosomal large subunit 1 Q96EH3 Mitochondrion matrix. Note=Colocalizes with MRPL12 (PubMed:22238375) and/or MRPL14 (PubMed:22829778). mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Cell.Organisms Cell.Organisms MALT1 HGNC:6819 mucosa associated lymphoid tissue lymphoma translocation gene 1 Q9UDY8 Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Nucleus (GO:0005634) 11090634,16123224,11090634,16123224 plasma membrane 10 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms MAMDC2 HGNC:23673 MAM domain containing 2 Q7Z304 Secreted, extracellular space, extracellular matrix (By similarity). Plasma membrane (GO:0005886) secreted 87 0 secreted secreted Euteleostomi Euteleostomi NA MAMDC4 HGNC:24083 MAM domain containing 4 Q6UXC1 Membrane; Single-pass type I membrane protein (By similarity). Endosome (GO:0005768) 7829488 plasma membrane 13 1 endosome endosome Deuterostomia Deuterostomia Cell.Organisms MAML1 HGNC:13632 mastermind-like 1 (Drosophila) Q92585 Nucleus speckle. Note=Nuclear, in a punctate manner. Nucleus (GO:0005634) 11390662,11101851 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Deuterostomia MAML2 HGNC:16259 mastermind-like 2 (Drosophila) Q8IZL2 Nucleus speckle. Note=Nuclear, in a punctate manner. Nucleus (GO:0005634) 12370315 nucleus 100 0 nucleus nucleus Mammalia Tetrapoda Craniata MAML3 HGNC:16272 mastermind-like 3 (Drosophila) Q96JK9 Nucleus speckle. Note=Nuclear, in a punctate manner. Nucleus (GO:0005634) 12386158 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa MAMLD1 HGNC:2568 mastermind-like domain containing 1 Q13495 Nucleus. Note=Punctate nuclear localization. nucleus 100 0 nucleus nucleus Mammalia Euteleostomi NA MAMSTR HGNC:26689 MEF2 activating motif and SAP domain containing transcriptional regulator Q6ZN01 Nucleus (By similarity). Nucleus (GO:0005634) 16818234 nucleus 72 0 nucleus nucleus Eutheria Eutheria Mammalia MAN1A1 HGNC:6821 mannosidase, alpha, class 1A, member 1 P33908 Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10409699,8223597,7588811 golgi apparatus membrane 100 1 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Cell.Organisms MAN1A2 HGNC:6822 mannosidase, alpha, class 1A, member 2 O60476 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 9592125 golgi apparatus membrane 100 2 golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Cell.Organisms MAN1B1 HGNC:6823 mannosidase, alpha, class 1B, member 1 Q9UKM7 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 10409699 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Human Eukaryota Cell.Organisms MAN1C1 HGNC:19080 mannosidase, alpha, class 1C, member 1 Q9NR34 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 10915796 golgi apparatus membrane 100 2 golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Cell.Organisms MAN2A1 HGNC:6824 mannosidase, alpha, class 2A, member 1 Q16706 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 1757461,11158608,8524845,1885615 golgi apparatus membrane 81 1 golgi apparatus golgi apparatus Bilateria Eukaryota Cell.Organisms MAN2A2 HGNC:6825 mannosidase, alpha, class 2A, member 2 P49641 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 8524845 golgi apparatus membrane 52 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms MAN2B1 HGNC:6826 mannosidase, alpha, class 2B, member 1 O00754 Lysosome. Lysosome (GO:0005764) 848490 golgi apparatus membrane 17 0 lysosome lysosome Theria Eukaryota Cell.Organisms MAN2B2 HGNC:29623 mannosidase, alpha, class 2B, member 2 Q9Y2E5 Secreted (Potential). Extracellular (GO:0005576) 10407159,9425289 secreted 70 0 secreted secreted Tetrapoda Deuterostomia Cell.Organisms MAN2C1 HGNC:6827 mannosidase, alpha, class 2C, member 1 Q9NTJ4 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2420791,8452531,6465,17081983 endoplasmic reticulum 85 0 cytoplasm. nucleus multiple Tetrapoda Cell.Organisms Cell.Organisms MANBA HGNC:6831 mannosidase, beta A, lysosomal O00462 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576) 8285582,14718574 secreted 15 0 lysosome. secreted multiple Bilateria Cell.Organisms Cell.Organisms MANBAL HGNC:15799 mannosidase, beta A, lysosomal-like Q9NQG1 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 46 1 nucleus nucleus Euteleostomi Euteleostomi Craniata MANEA HGNC:21072 mannosidase, endo-alpha Q5SRI9 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 9361017 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Cell.Organisms Cell.Organisms MANEAL HGNC:26452 mannosidase, endo-alpha-like Q5VSG8 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 48 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Cell.Organisms Cell.Organisms MANF HGNC:15461 mesencephalic astrocyte-derived neurotrophic factor P55145 Secreted. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 12628928,12628928,15635413 secreted 100 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria NA MANSC1 HGNC:25505 MANSC domain containing 1 Q9H8J5 Membrane; Single-pass type I membrane protein (Potential). nucleus 9 1 nucleus nucleus Eutheria Mammalia Euteleostomi MANSC4 HGNC:40023 MANSC domain containing 4 A6NHS7 Membrane; Single-pass type I membrane protein (Potential). secreted 84 1 secreted secreted Theria Amniota Euteleostomi MAOA HGNC:6833 monoamine oxidase A P21397 Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Mitochondrion (GO:0005739) 10647887 mitochondrion 24 1 mitochondrion. mitochondrion membrane multiple Deuterostomia Cell.Organisms Cell.Organisms MAOB HGNC:6834 monoamine oxidase B P27338 Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Mitochondrion (GO:0005739) 12913124 secreted 32 1 mitochondrion. mitochondrion membrane multiple Deuterostomia Cell.Organisms Cell.Organisms MAP10 HGNC:29265 microtubule-associated protein 10 Q9P2G4 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs. nucleus 92 0 cytoplasm cytoplasm Theria Theria Chordata MAP1A HGNC:6835 microtubule-associated protein 1A P78559 Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Perinuclear region (GO:0048471) 6142895,11925566,11896150,17081983,12123681,11896150,17081983,15202935 cytoplasm 28 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms MAP1B HGNC:6836 microtubule-associated protein 1B P46821 Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse (By similarity). Cell projection, dendritic spine (By similarity). Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12807913,11733546,10899930,17081983 nucleus 7 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa MAP1LC3A HGNC:6838 microtubule-associated protein 1 light chain 3 alpha Q9H492 Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Unknown membrane (None); Cytoplasm (GO:0005737);Microtubule (GO:0005874); Unknown membrane (None) 12740394,12740394/15857831,12740394 cytoplasm 50 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota MAP1LC3B HGNC:13352 microtubule-associated protein 1 light chain 3 beta Q9GZQ8 Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Integral to membrane (GO:0016021) 15355958 cytoplasm 48 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota MAP1LC3B2 HGNC:34390 microtubule-associated protein 1 light chain 3 beta 2 A6NCE7 Cytoplasm, cytoskeleton (By similarity). Endomembrane system; Lipid-anchor (By similarity). Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor (By similarity). Note=LC3-II binds to the autophagic membranes (By similarity). cytoplasm 47 0 cytoplasm cytoplasm Human Human Eukaryota MAP1LC3C HGNC:13353 microtubule-associated protein 1 light chain 3 gamma Q9BXW4 Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. cytoplasm 34 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota MAP1S HGNC:15715 microtubule-associated protein 1S Q66K74 Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. Microtubule (GO:0005874) 15205320 cytoplasm 20 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Bilateria MAP2 HGNC:6839 microtubule-associated protein 2 P11137 Cytoplasm, cytoskeleton (Probable). Nucleus (GO:0005634);Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 17081983/11029056,11029056 cytoplasm 30 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta MAP2K1 HGNC:6840 mitogen-activated protein kinase kinase 1 Q02750 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. Cytoplasm (GO:0005737) 8529659 cytoplasm 35 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms MAP2K2 HGNC:6842 mitogen-activated protein kinase kinase 2 P36507 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8529659,17081983,14656894,17081983 cytoplasm 30 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms MAP2K3 HGNC:6843 mitogen-activated protein kinase kinase 3 P46734 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9768359,9768359 cytoplasm 24 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms MAP2K4 HGNC:6844 mitogen-activated protein kinase kinase 4 P45985 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829);Plasma membrane (GO:0005886) 10187804,10187804,,19898473,/,19898473, cytoplasm 39 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms MAP2K5 HGNC:6845 mitogen-activated protein kinase kinase 5 Q13163 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 7499418,15075238,9384584,14583600,15075238,14583600,14583600 cytoplasm 30 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms MAP2K6 HGNC:6846 mitogen-activated protein kinase kinase 6 P52564 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Binds to microtubules. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9768359,9768359 cytoplasm 32 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms MAP2K7 HGNC:6847 mitogen-activated protein kinase kinase 7 O14733 Nucleus. Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9891090,13130464,9891090,13130464 cytoplasm 25 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms MAP3K1 HGNC:6848 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Q13233 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms MAP3K10 HGNC:6849 mitogen-activated protein kinase kinase kinase 10 Q02779 Cytoplasm (GO:0005737) 9427749 cytoplasm 44 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms MAP3K11 HGNC:6850 mitogen-activated protein kinase kinase kinase 11 Q16584 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent. Cytoplasm (GO:0005737) 12529434 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms MAP3K12 HGNC:6851 mitogen-activated protein kinase kinase kinase 12 Q12852 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10490457,10187804,10187804,10187804 secreted 23 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms MAP3K13 HGNC:6852 mitogen-activated protein kinase kinase kinase 13 O43283 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) 12492477 cytoplasm 19 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAP3K14 HGNC:6853 mitogen-activated protein kinase kinase kinase 14 Q99558 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11801607,11801607 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms MAP3K15 HGNC:31689 mitogen-activated protein kinase kinase kinase 15 Q6ZN16 cytoplasm 22 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAP3K19 HGNC:26249 mitogen-activated protein kinase kinase kinase 19 Q56UN5 cytoplasm 29 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms MAP3K2 HGNC:6854 mitogen-activated protein kinase kinase kinase 2 Q9Y2U5 Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus. cytoplasm 26 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms MAP3K3 HGNC:6855 mitogen-activated protein kinase kinase kinase 3 Q99759 Nucleus (GO:0005634) cytoplasm 25 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms MAP3K4 HGNC:6856 mitogen-activated protein kinase kinase kinase 4 Q9Y6R4 Cytoplasm, perinuclear region (By similarity). Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles (By similarity). Perinuclear vesicle (None) 9079650 cytoplasm 86 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Cell.Organisms MAP3K5 HGNC:6857 mitogen-activated protein kinase kinase kinase 5 Q99683 Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9651337,12543931 cytoplasm 20 0 cytoplasm. endoplasmic reticulum. secreted multiple Bilateria Bilateria Cell.Organisms MAP3K6 HGNC:6858 mitogen-activated protein kinase kinase kinase 6 O95382 nucleus 18 0 nucleus nucleus Bilateria Bilateria Cell.Organisms MAP3K7 HGNC:6859 mitogen-activated protein kinase kinase kinase 7 O43318 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 17081983/7708055,10882101,,12242293,19898473,,,19898473, cytoplasm 14 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms MAP3K7CL HGNC:16457 MAP3K7 C-terminal like P57077 nucleus 51 0 nucleus nucleus Eutheria Deuterostomia Bilateria MAP3K8 HGNC:6860 mitogen-activated protein kinase kinase kinase 8 P41279 Cytoplasm. Cytoplasm (GO:0005737) 8226782 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms MAP3K9 HGNC:6861 mitogen-activated protein kinase kinase kinase 9 P80192 cytoplasm 46 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms MAP4 HGNC:6862 microtubule-associated protein 4 P27816 Cytoplasm, cytoskeleton. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Microtubule (GO:0005874) 17081983,17081983/7909279,1905296,17081983,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota MAP4K1 HGNC:6863 mitogen-activated protein kinase kinase kinase kinase 1 Q92918 Cytoplasm (GO:0005737) 11278340 cytoplasm 36 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAP4K2 HGNC:6864 mitogen-activated protein kinase kinase kinase kinase 2 Q12851 Cytoplasm (By similarity). Basolateral cell membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 8643544,8643544,8643544 cytoplasm 43 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Cell.Organisms MAP4K3 HGNC:6865 mitogen-activated protein kinase kinase kinase kinase 3 Q8IVH8 Cytoplasm (GO:0005737) 12127567 cytoplasm 64 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAP4K4 HGNC:6866 mitogen-activated protein kinase kinase kinase kinase 4 O95819 Cytoplasm. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 14966141,14966141 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAP4K5 HGNC:6867 mitogen-activated protein kinase kinase kinase kinase 5 Q9Y4K4 Cytoplasm. Cytoplasm (GO:0005737) 9038372 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MAP6 HGNC:6868 microtubule-associated protein 6 Q96JE9 Cytoplasm, cytoskeleton. Golgi apparatus (By similarity). Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS). Cytoskeleton (GO:0005856); Axon (GO:0030424); Synaptic vesicle (GO:0008021) 8700896,12231625,12231625 secreted 17 0 cytoplasm cytoplasm Eutheria Euteleostomi Cell.Organisms MAP6D1 HGNC:25753 MAP6 domain containing 1 Q9H9H5 Golgi apparatus. Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with microtubules (By similarity). Golgi apparatus (GO:0005794); Microtubule (GO:0005874) 16837464,16837464 nucleus 19 0 golgi apparatus golgi apparatus Theria Euteleostomi Euteleostomi MAP7 HGNC:6869 microtubule-associated protein 7 Q14244 Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Microtubule (GO:0005874) 9989799,17081983,12755995,17081983,15561729 nucleus 31 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata MAP7D1 HGNC:25514 MAP7 domain containing 1 Q3KQU3 Cytoplasm, cytoskeleton, spindle. cytoplasm 100 0 cytoplasm cytoplasm Eutheria Chordata Euteleostomi MAP7D2 HGNC:25899 MAP7 domain containing 2 Q96T17 cytoplasm 30 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Euteleostomi MAP7D3 HGNC:25742 MAP7 domain containing 3 Q8IWC1 Cytoplasm, cytoskeleton, spindle. Note=Localizes to the microtubules throughout mitosis. cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms MAP9 HGNC:26118 microtubule-associated protein 9 Q49MG5 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis. Cytoplasm (GO:0005737) 16049101 cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Euteleostomi MAPK1 HGNC:6871 mitogen-activated protein kinase 1 P28482 Cytoplasm, cytoskeleton, spindle (By similarity). Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12149268,11741894,12592337,15928662,15595556,17255949,17290218,12149268,11741894,9604935,12592337,15928662,15595556,15557324,17255949,17290218,12943720 nucleus 42 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms MAPK10 HGNC:6872 mitogen-activated protein kinase 10 P53779 Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). Vesicle (None); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11090355,11185509,7826642,11090355,11185509 nucleus 35 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms MAPK11 HGNC:6873 mitogen-activated protein kinase 11 Q15759 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15048855,10820433,15048855 nucleus 59 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms MAPK12 HGNC:6874 mitogen-activated protein kinase 12 P53778 Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle co-localizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11991731,17081983 nucleus 48 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms MAPK13 HGNC:6875 mitogen-activated protein kinase 13 O15264 Cytoplasm (GO:0005737); Cytosol (GO:0005829) ,15561729 nucleus 48 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms MAPK14 HGNC:6876 mitogen-activated protein kinase 14 Q16539 Cytoplasm. Nucleus. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11866441/7535770,17255949,9768359,17081983,7535770,17255949,9768359,17081983 nucleus 64 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms MAPK15 HGNC:24667 mitogen-activated protein kinase 15 Q8TD08 nucleus 64 0 nucleus nucleus Eukaryota Eukaryota NA MAPK1IP1L HGNC:19840 mitogen-activated protein kinase 1 interacting protein 1-like Q8NDC0 Nucleus (GO:0005634) 17081983 cytoplasm 56 0 nucleus nucleus Theria Amniota Amniota MAPK3 HGNC:6877 mitogen-activated protein kinase 3 P27361 Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829); Chromosome (GO:0005694) 11682603,17255949,17290218,17081983,11682603,17255949,15580310,17290218,12943720,17081983,15580310,11129339 nucleus 40 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms MAPK4 HGNC:6878 mitogen-activated protein kinase 4 P31152 Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the cytoplasm following interaction with MAPKAPK5 (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) none,18720373, nucleus 25 0 nucleus nucleus Deuterostomia Deuterostomia NA MAPK6 HGNC:6879 mitogen-activated protein kinase 6 Q16659 Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the cytoplasm following interaction with MAPKAPK5 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8621539,18720373,12915405 nucleus 27 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms MAPK7 HGNC:6880 mitogen-activated protein kinase 7 Q13164 Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 12042304,15692064,15716121,15548525,11139578,12042304,15692064,15716121,15548525,11139578,15075238,14718574,9461566 nucleus 37 0 cytoplasm. nucleus. secreted multiple Eukaryota Eukaryota Cell.Organisms MAPK8 HGNC:6881 mitogen-activated protein kinase 8 P45983 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9195981,15580310,12514174,9195981,12514174 nucleus 38 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms MAPK8IP1 HGNC:6882 mitogen-activated protein kinase 8 interacting protein 1 Q9UQF2 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9442013,,9442013,10490659, cytoplasm 48 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Holozoa MAPK8IP2 HGNC:6883 mitogen-activated protein kinase 8 interacting protein 2 Q13387 Cytoplasm. Note=Accumulates in cell surface projections. Cytoplasm (GO:0005737) 10490659,12524447 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa MAPK8IP3 HGNC:6884 mitogen-activated protein kinase 8 interacting protein 3 Q9UPT6 Cytoplasm (By similarity). Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737) 11106729,10629060,10523642 cytoplasm 51 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa MAPK9 HGNC:6886 mitogen-activated protein kinase 9 P45984 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15778501,10381549,15637069,10381549 nucleus 36 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms MAPKAP1 HGNC:18752 mitogen-activated protein kinase associated protein 1 Q9BPZ7 Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 15722200,15722200,15722200 nucleus 64 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta MAPKAPK2 HGNC:6887 mitogen-activated protein kinase-activated protein kinase 2 P49137 Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9628873,12171911,9768359,9628873,12171911,9768359 nucleus 22 1 cytoplasm. nucleus multiple Bilateria Cell.Organisms NA MAPKAPK3 HGNC:6888 mitogen-activated protein kinase-activated protein kinase 3 Q16644 Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11157753,11157753 nucleus 19 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms MAPKAPK5 HGNC:6889 mitogen-activated protein kinase-activated protein kinase 5 Q8IW41 Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12808055,12808055,18720373 cytoplasm 20 1 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms MAPKBP1 HGNC:29536 mitogen-activated protein kinase binding protein 1 O60336 cytoplasm 9 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms MAPRE1 HGNC:6890 microtubule-associated protein, RP/EB family, member 1 Q15691 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 10030671,12475954,12475954 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MAPRE2 HGNC:6891 microtubule-associated protein, RP/EB family, member 2 Q15555 Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules. Cytoplasm (GO:0005737);Centrosome (GO:0005813); Cytoskeleton (GO:0005856); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 17081983/12388762,9724749,12388762,9724749,10030671,12475954,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Amniota Eukaryota Eukaryota MAPRE3 HGNC:6892 microtubule-associated protein, RP/EB family, member 3 Q9UPY8 Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Detected at the plus end of microtubules. Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 10644998,10644998 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota MAPT HGNC:6893 microtubule-associated protein tau P10636 Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10747907,10747907,12527113 cytoplasm 22 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta MARC1 HGNC:26189 mitochondrial amidoxime reducing component 1 Q5VT66 Mitochondrion outer membrane; Single-pass type II membrane protein. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms MARC2 HGNC:26064 mitochondrial amidoxime reducing component 2 Q969Z3 Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome (By similarity). Mitochondrial membrane (GO:0005740) 16973608 mitochondrion membrane 58 1 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms MARCH1 HGNC:26077 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase Q8TCQ1 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lysosome (GO:0005764) 14722266 endoplasmic reticulum membrane 36 2 endosome. endosome membrane. lysosome. plasma membrane multiple Euarchontoglires Euteleostomi Eukaryota MARCH10 HGNC:26655 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase Q8NA82 endoplasmic reticulum membrane 40 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Mammalia Eukaryota MARCH11 HGNC:33609 membrane-associated ring finger (C3HC4) 11 A6NNE9 Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 52 2 golgi apparatus membrane golgi apparatus membrane Tetrapoda Euteleostomi Eukaryota MARCH2 HGNC:28038 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase Q9P0N8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein (By similarity). Microsome (GO:0005792); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endosome (GO:0005768) 15689499,14722266,15689499,15689499 endoplasmic reticulum membrane 23 2 endoplasmic reticulum membrane. endosome. golgi apparatus. lysosome membrane. plasma membrane multiple Human Eukaryota Eukaryota MARCH3 HGNC:28728 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase Q86UD3 Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 38 2 endosome endosome Eutheria Bilateria Eukaryota MARCH4 HGNC:29269 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase Q9P2E8 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 10718198 golgi apparatus membrane 100 2 golgi apparatus. golgi apparatus membrane multiple Chordata Chordata Eukaryota MARCH5 HGNC:26025 membrane-associated ring finger (C3HC4) 5 Q9NX47 Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739); Integral to membrane (GO:0016021) 16936636,16874301,16874301,16874301 golgi apparatus membrane 34 4 mitochondrion. mitochondrion membrane multiple Opisthokonta Opisthokonta Eukaryota MARCH6 HGNC:30550 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase O60337 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 15 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota MARCH7 HGNC:17393 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase Q9H992 endoplasmic reticulum membrane 41 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota MARCH8 HGNC:23356 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase Q5T0T0 Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Endosome (GO:0005768); Nucleus (GO:0005634); Integral to membrane (GO:0016021) 14722266,12582153,12582153 endoplasmic reticulum membrane 38 2 endosome. lysosome membrane. nucleus multiple Deuterostomia Eukaryota NA MARCH9 HGNC:25139 membrane-associated ring finger (C3HC4) 9 Q86YJ5 Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Lysosome (GO:0005764) 14722266,17174307 golgi apparatus membrane 70 2 golgi apparatus. golgi apparatus membrane. lysosome. lysosome membrane multiple Theria Euteleostomi Eukaryota MARCKS HGNC:6759 myristoylated alanine-rich protein kinase C substrate P29966 Cytoplasm, cytoskeleton (Probable). Membrane; Lipid-anchor (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11533058,11533058 nucleus membrane 14 0 cytoplasm cytoplasm Euarchontoglires Euteleostomi Euteleostomi MARCKSL1 HGNC:7142 MARCKS-like 1 P49006 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity). nucleus 61 0 nucleus nucleus Theria Euteleostomi Amniota MARCO HGNC:6895 macrophage receptor with collagenous structure Q9UEW3 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 7867067,9468508 secreted 40 1 plasma membrane plasma membrane Theria Euteleostomi Eukaryota MARK1 HGNC:6896 MAP/microtubule affinity-regulating kinase 1 Q9P0L2 Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton (By similarity). Note=Appears to localize to an intracellular network (By similarity). Cytoplasm (GO:0005737) 14594945 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms MARK2 HGNC:3332 MAP/microtubule affinity-regulating kinase 2 Q7KZI7 Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 15324659,15324659,15324659,17081983 cytoplasm 29 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms MARK3 HGNC:6897 MAP/microtubule affinity-regulating kinase 3 P27448 Cell membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms MARK4 HGNC:13538 MAP/microtubule affinity-regulating kinase 4 Q96L34 Cytoplasm (GO:0005737); Centrosome (GO:0005813); Microtubule (GO:0005874) 11326310,14594945,15561729 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms MARS HGNC:6898 methionyl-tRNA synthetase P56192 Cytoplasm (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 10791971,10791971,15598749,15561729 cytoplasm 40 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MARS2 HGNC:25133 methionyl-tRNA synthetase 2, mitochondrial Q96GW9 Mitochondrion matrix (Probable). mitochondrion 29 0 mitochondrion mitochondrion NA NA Cell.Organisms MARVELD1 HGNC:28674 MARVEL domain containing 1 Q9BSK0 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 71 4 nucleus nucleus Euteleostomi Euteleostomi Craniata MARVELD2 HGNC:26401 MARVEL domain containing 2 Q8N4S9 Cell membrane; Multi-pass membrane protein. Cell junction, tight junction (By similarity). Note=Found at tricellular contacts (By similarity). Nucleus (GO:0005634) 17081983 nucleus 23 4 nucleus. plasma membrane multiple Euteleostomi Euteleostomi NA MARVELD3 HGNC:30525 MARVEL domain containing 3 Q96A59 Membrane; Multi-pass membrane protein (Potential). Cell junction, tight junction. Integral to membrane (GO:0016021) cytoplasm 22 4 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata MAS1 HGNC:6899 MAS1 oncogene P04201 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11967280 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Bilateria MAS1L HGNC:13961 MAS1 oncogene-like P35410 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Human Catarrhini NA MASP1 HGNC:6901 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) P48740 Secreted. Extracellular (GO:0005576) 10946292 secreted 100 0 secreted secreted Chordata Chordata Cell.Organisms MASP2 HGNC:6902 mannan-binding lectin serine peptidase 2 O00187 Secreted. Extracellular (GO:0005576) 10946292,16188874 secreted 100 0 secreted secreted Human Euteleostomi Cell.Organisms MAST1 HGNC:19034 microtubule associated serine/threonine kinase 1 Q9Y2H9 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with syntrophins at the cell membrane (By similarity). Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 12614677,10404183,17081983 cytoplasm 20 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms MAST2 HGNC:19035 microtubule associated serine/threonine kinase 2 Q6P0Q8 Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Note=Recruited to the sub-membranous area on interaction with CDHR2. Cytoskeleton (GO:0005856); Cytosol (GO:0005829); Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 8246979,16159897,16159897/12117771 nucleus 28 1 cytoplasm. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms MAST3 HGNC:19036 microtubule associated serine/threonine kinase 3 O60307 nucleus 24 1 nucleus nucleus Eukaryota Eukaryota Cell.Organisms MAST4 HGNC:19037 microtubule associated serine/threonine kinase family member 4 O15021 Cytoplasm (Potential). nucleus 26 2 nucleus nucleus Eukaryota Eukaryota Cell.Organisms MASTL HGNC:19042 microtubule associated serine/threonine kinase-like Q96GX5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. nucleus 12 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms MAT1A HGNC:6903 methionine adenosyltransferase I, alpha Q00266 Cytoplasm (GO:0005737) 7213623,1056281 cytoplasm 54 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms MAT2A HGNC:6904 methionine adenosyltransferase II, alpha P31153 Cytoplasm (GO:0005737) 7213623 cytoplasm 58 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms MAT2B HGNC:6905 methionine adenosyltransferase II, beta Q9NZL9 Cytoplasm (GO:0005737) 7213623 cytoplasm 31 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms MATK HGNC:6906 megakaryocyte-associated tyrosine kinase P42679 Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15748901,15748901,8288563 cytoplasm 25 0 cytoplasm. nucleus multiple Amniota Euteleostomi Cell.Organisms MATN1 HGNC:6907 matrilin 1, cartilage matrix protein P21941 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 2246248 secreted 100 0 secreted secreted Chordata Eukaryota Cell.Organisms MATN2 HGNC:6908 matrilin 2 O00339 Secreted. Extracellular matrix (GO:0005578);Extracellular matrix (GO:0005578) 11124542/12180907 secreted 100 0 secreted secreted Bilateria Eukaryota Cell.Organisms MATN3 HGNC:6909 matrilin 3 O15232 Secreted. Extracellular (GO:0005576) 11479597 secreted 100 0 secreted secreted Eutheria Euteleostomi Cell.Organisms MATN4 HGNC:6910 matrilin 4 O95460 Secreted. Extracellular (GO:0005576) 11279097 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms MATR3 HGNC:6912 matrin 3 P43243 Nucleus matrix. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 9757574,19059367,15598749,17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Eukaryota MAU2 HGNC:29140 MAU2 sister chromatid cohesion factor Q9Y6X3 Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase. Chromosome (GO:0005694) 17113138 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota MAVS HGNC:29233 mitochondrial antiviral signaling protein Q7Z434 Mitochondrion outer membrane. Mitochondrion. Peroxisome. plasma membrane 11 1 mitochondrion. peroxisome multiple Eutheria Eutheria Chordata MAX HGNC:6913 MYC associated factor X P61244 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/11031250,1566084,1566084 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Eukaryota MAZ HGNC:6914 MYC-associated zinc finger protein (purine-binding transcription factor) P56270 Nucleus (Probable). Note=In brains of Alzheimer disease patients, present in a plaque-like structures. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8626793,11527412 nucleus 97 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota MB HGNC:6915 myoglobin P02144 Sarcoplasm (GO:0016528) 14506721 cytoplasm 12 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms MB21D1 HGNC:21367 Mab-21 domain containing 1 Q8N884 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Eumetazoa MB21D2 HGNC:30438 Mab-21 domain containing 2 Q8IYB1 plasma membrane 20 0 n/a n/a Chordata Chordata Eumetazoa MBD1 HGNC:6916 methyl-CpG binding domain protein 1 Q9UIS9 Nucleus (By similarity). Nucleus matrix (By similarity). Nucleus speckle. Chromosome. Note=Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/10648624,10454587 nucleus 65 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa MBD2 HGNC:6917 methyl-CpG binding domain protein 2 Q9UBB5 Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9774669,15456747,17081983/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Human Bilateria Eukaryota MBD3 HGNC:6918 methyl-CpG binding domain protein 3 O95983 Nucleus. Note=Nuclear, in discrete foci. Nucleus (GO:0005634); Mitochondrion (GO:0005739);Cytoplasm (GO:0005737) 10947852,15598749/17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Euteleostomi Metazoa MBD3L1 HGNC:15774 methyl-CpG binding domain protein 3-like 1 Q8WWY6 Nucleus. Note=Nuclear, in large foci. Nucleus (GO:0005634) 12504854 nucleus 100 0 nucleus nucleus Eutheria Eutheria Eumetazoa MBD3L2 HGNC:18532 methyl-CpG binding domain protein 3-like 2 Q8NHZ7 nucleus 28 0 nucleus nucleus NA NA Bilateria MBD3L3 HGNC:37205 methyl-CpG binding domain protein 3-like 3 A6NE82 nucleus 29 0 nucleus nucleus Euarchontoglires Euarchontoglires Bilateria MBD3L4 HGNC:37206 methyl-CpG binding domain protein 3-like 4 A6NDZ8 nucleus 29 0 nucleus nucleus Euarchontoglires Euarchontoglires Bilateria MBD3L5 HGNC:37204 methyl-CpG binding domain protein 3-like 5 A6NJ08 nucleus 28 0 nucleus nucleus NA NA Bilateria MBD4 HGNC:6919 methyl-CpG binding domain protein 4 O95243 Nucleus. Nucleus (GO:0005634) 9774669 nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms MBD5 HGNC:20444 methyl-CpG binding domain protein 5 Q9P267 Isoform 1: Nucleus. Chromosome. Isoform 2: Nucleus. Note=Not associated with pericentric heterochromatin. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa MBD6 HGNC:20445 methyl-CpG binding domain protein 6 Q96DN6 Nucleus. Chromosome. Note=Associated with pericentric heterochromatin in about 25% of the cells. nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Metazoa MBIP HGNC:20427 MAP3K12 binding inhibitory protein 1 Q9NS73 Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10801814,10801814 nucleus 73 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota MBL2 HGNC:6922 mannose-binding lectin (protein C) 2, soluble P11226 Secreted. Extracellular (GO:0005576) 9570553 secreted 100 0 secreted secreted Amniota Amniota Cell.Organisms MBLAC1 HGNC:22180 metallo-beta-lactamase domain containing 1 A4D2B0 cytoplasm 40 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms MBLAC2 HGNC:33711 metallo-beta-lactamase domain containing 2 Q68D91 cytoplasm 51 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms MBNL1 HGNC:6923 muscleblind-like splicing regulator 1 Q9NR56 Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes. Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 10970838,11929853/10970838,11929853,15961406,11433021,11433021/15961406 nucleus 43 0 cytoplasm. nucleus multiple Human Bilateria Eukaryota MBNL2 HGNC:16746 muscleblind-like splicing regulator 2 Q5VZF2 Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11929853,11929853 nucleus 40 0 cytoplasm. nucleus multiple Human Bilateria Eukaryota MBNL3 HGNC:20564 muscleblind-like splicing regulator 3 Q9NUK0 Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11929853,11929853 nucleus 44 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota MBOAT1 HGNC:21579 membrane bound O-acyltransferase domain containing 1 Q6ZNC8 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 10 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Mammalia Eukaryota MBOAT2 HGNC:25193 membrane bound O-acyltransferase domain containing 2 Q6ZWT7 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 7 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota MBOAT4 HGNC:32311 membrane bound O-acyltransferase domain containing 4 Q96T53 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 73 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Euarchontoglires Euteleostomi Eukaryota MBOAT7 HGNC:15505 membrane bound O-acyltransferase domain containing 7 Q96N66 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) ,15561729 endoplasmic reticulum membrane 10 11 plasma membrane plasma membrane Bilateria Bilateria NA MBP HGNC:6925 myelin basic protein P02686 Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 17081983/9136767,9136767,9136767 nucleus 47 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata MBTD1 HGNC:19866 mbt domain containing 1 Q05BQ5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Bilateria Bilateria Holozoa MBTPS1 HGNC:15456 membrane-bound transcription factor peptidase, site 1 Q14703 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=May sort to other organelles, including lysosomal and/or endosomal compartments. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764); Endosome (GO:0005768) 10619424,11821395,10619424,10944850,9990022,9990022 secreted 20 1 endoplasmic reticulum. endoplasmic reticulum membrane. endosome. golgi apparatus. golgi apparatus membrane. lysosome multiple Euteleostomi Cell.Organisms Cell.Organisms MBTPS2 HGNC:15455 membrane-bound transcription factor peptidase, site 2 O43462 Membrane; Multi-pass membrane protein (Probable). Cytoplasm. Golgi apparatus (GO:0005794) 11795864 golgi apparatus membrane 33 7 cytoplasm. golgi apparatus multiple Bilateria Cell.Organisms Cell.Organisms MC1R HGNC:6929 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Q01726 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1516719 plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa MC2R HGNC:6930 melanocortin 2 receptor (adrenocorticotropic hormone) Q01718 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9175632 plasma membrane 100 7 plasma membrane plasma membrane Amniota Amniota Eumetazoa MC3R HGNC:6931 melanocortin 3 receptor P41968 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8463333,12077332 plasma membrane 100 7 nucleus. plasma membrane multiple Mammalia Euteleostomi Eumetazoa MC4R HGNC:6932 melanocortin 4 receptor P32245 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10585465 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa MC5R HGNC:6933 melanocortin 5 receptor P33032 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8396929,7739752 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa MCAM HGNC:6934 melanoma cell adhesion molecule P43121 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12496470,12406332,9462829,10726166,17081983 secreted 10 1 cytoplasm. nucleus. plasma membrane. secreted multiple Euteleostomi Bilateria Metazoa MCAT HGNC:29622 malonyl CoA:ACP acyltransferase (mitochondrial) Q8IVS2 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12882974,17000644 mitochondrion 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MCC HGNC:6935 mutated in colorectal cancers P23508 Cell membrane. Nucleus. Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 8626604,8626604,8626604 nucleus 12 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Eumetazoa MCCC1 HGNC:6936 methylcrotonoyl-CoA carboxylase 1 (alpha) Q96RQ3 Mitochondrion matrix. Mitochondrion (GO:0005739) 11406611 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MCCC2 HGNC:6937 methylcrotonoyl-CoA carboxylase 2 (beta) Q9HCC0 Mitochondrion matrix. Mitochondrion (GO:0005739) 11406611 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms NA MCCD1 HGNC:20668 mitochondrial coiled-coil domain 1 P59942 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 14527716,14527716 mitochondrion 100 0 cytoplasm. mitochondrion multiple Catarrhini Theria NA MCEE HGNC:16732 methylmalonyl CoA epimerase Q96PE7 Mitochondrion (Probable). Mitochondrion (GO:0005739) 15598749 mitochondrion 22 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms MCF2 HGNC:6940 MCF.2 cell line derived transforming sequence P10911 Cytoplasm. Isoform 1: Membrane. Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 3281159,3056717,3491366,11907027 cytoplasm 13 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota MCF2L HGNC:14576 MCF.2 cell line derived transforming sequence-like O15068 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 14701795,15531584,15531584,7957046,15531584 cytoplasm 8 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Eukaryota MCF2L2 HGNC:30319 MCF.2 cell line derived transforming sequence-like 2 Q86YR7 cytoplasm 13 2 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta MCFD2 HGNC:18451 multiple coagulation factor deficiency 2 Q8NI22 Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 12832409,12832409,12832409,12832409 secreted 18 0 endoplasmic reticulum. golgi apparatus. nucleus. secreted multiple Bilateria Bilateria Opisthokonta MCHR1 HGNC:4479 melanin-concentrating hormone receptor 1 Q99705 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 8 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa MCHR2 HGNC:20867 melanin-concentrating hormone receptor 2 Q969V1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Metazoa MCIDAS HGNC:40050 multiciliate differentiation and DNA synthesis associated cell cycle protein D6RGH6 Nucleus. Note=Excluded from the nucleolus. nucleus 100 0 nucleus nucleus NA NA Deuterostomia MCL1 HGNC:6943 myeloid cell leukemia 1 Q07820 Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. Mitochondrial membrane (GO:0005740); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7896880,7896880,12149273 plasma membrane 17 1 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms MCM10 HGNC:18043 minichromosome maintenance complex component 10 Q7L590 Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli. Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 11095689/11095689,15136575,15136575,15136575 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota MCM2 HGNC:6944 minichromosome maintenance complex component 2 P49736 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694) 8258304,15635413,16902406 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms MCM3 HGNC:6945 minichromosome maintenance complex component 3 P25205 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Mitochondrion (GO:0005739) 7615659,15635413,16902406,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms MCM3AP HGNC:6946 minichromosome maintenance complex component 3 associated protein O60318 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11024281,9712829,12226073,11024281 nucleus 21 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota MCM4 HGNC:6947 minichromosome maintenance complex component 4 P33991 Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694) 8265339,15635413,16902406 nucleus 83 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms MCM5 HGNC:6948 minichromosome maintenance complex component 5 P33992 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Mitochondrion (GO:0005739) 7705359,15561729,15635413,16902406,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms MCM6 HGNC:6949 minichromosome maintenance complex component 6 Q14566 Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694) 9516426,9286856,16438930,15635413,16902406 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms MCM7 HGNC:6950 minichromosome maintenance complex component 7 P33993 Nucleus (By similarity). Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694) 8626784/8626784,8631321,9099751,16438930,15635413,16902406 nucleus 80 0 nucleus nucleus Theria Eukaryota Cell.Organisms MCM8 HGNC:16147 minichromosome maintenance complex component 8 Q9UJA3 Nucleus. Note=Localizes to nuclear foci and colocalizes with RAD51. Nucleus (GO:0005634) 12527764 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms MCM9 HGNC:21484 minichromosome maintenance complex component 9 Q9NXL9 Nucleus (By similarity). Note=Localizes to nuclear foci and colocalizes with RAD51 (By similarity). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms MCMBP HGNC:25782 minichromosome maintenance complex binding protein Q9BTE3 Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota MCMDC2 HGNC:26368 minichromosome maintenance domain containing 2 Q4G0Z9 cytoplasm 24 0 cytoplasm cytoplasm Tetrapoda Bilateria Cell.Organisms MCOLN1 HGNC:13356 mucolipin 1 Q9GZU1 Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11013137 endoplasmic reticulum membrane 13 7 endosome membrane. lysosome membrane. plasma membrane multiple Bilateria Eukaryota Eukaryota MCOLN2 HGNC:13357 mucolipin 2 Q8IZK6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 29 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota MCOLN3 HGNC:13358 mucolipin 3 Q8TDD5 Membrane; Multi-pass membrane protein (Potential). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12403827,12403827 endoplasmic reticulum membrane 24 7 cytoplasm. plasma membrane multiple Bilateria Eukaryota Eukaryota MCPH1 HGNC:6954 microcephalin 1 Q8NEM0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota MCRS1 HGNC:6960 microspherule protein 1 Q96EZ8 Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus. Nucleus (GO:0005634); Chromosome (GO:0005694); Nucleolus (GO:0005730);Nucleolus (GO:0005730); Nucleus (GO:0005634) 11948183,16230350,15044100,11948183,9654073/15044100,17081983 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota MCTP1 HGNC:26183 multiple C2 domains, transmembrane 1 Q6DN14 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 15528213 cytoplasm 16 5 cytoplasm cytoplasm Bilateria Bilateria NA MCTP2 HGNC:25636 multiple C2 domains, transmembrane 2 Q6DN12 Membrane; Multi-pass membrane protein (Potential). Endocytic vesicle (GO:0030139) 15528213 cytoplasm 24 3 cytoplasm cytoplasm Bilateria Bilateria Eukaryota MCTS1 HGNC:23357 malignant T cell amplified sequence 1 Q9ULC4 Cytoplasm. Note=Nuclear relocalization after DNA damage. Cytoplasm (GO:0005737) 11709712 cytoplasm 100 0 cytoplasm cytoplasm NA NA Cell.Organisms MCU HGNC:23526 mitochondrial calcium uniporter Q8NE86 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 2 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota MCUR1 HGNC:21097 mitochondrial calcium uniporter regulator 1 Q96AQ8 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Amniota Eukaryota Eukaryota MDC1 HGNC:21163 mediator of DNA-damage checkpoint 1 Q14676 Nucleus. Chromosome (By similarity). Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AFX. Colocalizes with APTX at sites of DNA double-strand breaks. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/12475977,10975465,12499369,19059367,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Theria NA MDFI HGNC:6967 MyoD family inhibitor Q99750 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8797820,8797820 secreted 38 0 cytoplasm. nucleus multiple Amniota Euteleostomi Euteleostomi MDFIC HGNC:28870 MyoD family inhibitor domain containing Q9P1T7 Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm. Note=Weak expression in the nucleus. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10671520,10671520,10671520 secreted 93 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata MDGA1 HGNC:19267 MAM domain containing glycosylphosphatidylinositol anchor 1 Q8NFP4 Cell membrane; Lipid-anchor, GPI-anchor. Note=Associated with lipid rafts. Plasma membrane (GO:0005886) 12082541 secreted 21 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms MDGA2 HGNC:19835 MAM domain containing glycosylphosphatidylinositol anchor 2 Q7Z553 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Integral to membrane (GO:0016021) secreted 23 1 secreted secreted Chordata Chordata Cell.Organisms MDH1 HGNC:6970 malate dehydrogenase 1, NAD (soluble) P40925 Cytoplasm. Cytoplasm (GO:0005737); Cytosol (GO:0005829); Mitochondrion (GO:0005739) 8786100,10075524,16263121,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms MDH1B HGNC:17836 malate dehydrogenase 1B, NAD (soluble) Q5I0G3 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms MDH2 HGNC:6971 malate dehydrogenase 2, NAD (mitochondrial) P40926 Mitochondrion matrix. Mitochondrion (GO:0005739); Nucleolus (GO:0005730); Extracellular (GO:0005576) 3591372,15635413,16188874 mitochondrion 100 0 mitochondrion. nucleus. secreted multiple Opisthokonta Cell.Organisms NA MDK HGNC:6972 midkine (neurite growth-promoting factor 2) P21741 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 12579281,15781266,15781266,11048798 secreted 100 0 cytoplasm. nucleus. secreted multiple Euarchontoglires Euteleostomi Chordata MDM1 HGNC:29917 Mdm1 nuclear protein homolog (mouse) Q8TC05 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 3182840,3182840 nucleus 65 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Eumetazoa MDM2 HGNC:6973 MDM2 oncogene, E3 ubiquitin protein ligase Q00987 Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Nucleoplasm (GO:0005654) ,12393906,11504915,16212962,17879958,,,12393906,11504915,16212962,17170761,18566590,,10713175,12842086,12842086 nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta MDM4 HGNC:6974 MDM4, p53 regulator O15151 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) ,12370303,16511572,15604276,16511560,17159902,,12370303,16511560,16511572,15604276,11297540 nucleus 100 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota MDN1 HGNC:18302 MDN1, midasin homolog (yeast) Q9NU22 Nucleus (By similarity). Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12102729,17081983,15635413 nucleus 32 3 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms MDP1 HGNC:28781 magnesium-dependent phosphatase 1 Q86V88 cytoplasm 39 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms MDS2 HGNC:29633 myelodysplastic syndrome 2 translocation associated Q8NDY4 secreted 57 1 secreted secreted Homininae Homininae Homo ME1 HGNC:6983 malic enzyme 1, NADP(+)-dependent, cytosolic P48163 Cytoplasm. Cytoplasm (GO:0005737) 8187880,8804575 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms ME2 HGNC:6984 malic enzyme 2, NAD(+)-dependent, mitochondrial P23368 Mitochondrion matrix. Mitochondrion (GO:0005739) 1993674,11358520,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms ME3 HGNC:6985 malic enzyme 3, NADP(+)-dependent, mitochondrial Q16798 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 7818469,7818469 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms MEA1 HGNC:6986 male-enhanced antigen 1 Q16626 Cytoplasm (GO:0005737) 12444059 nucleus 82 0 cytoplasm cytoplasm Mammalia Euteleostomi Eumetazoa MEAF6 HGNC:25674 MYST/Esa1-associated factor 6 Q9HAF1 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota MECOM HGNC:3498 MDS1 and EVI1 complex locus Q03112 Nucleus. Nucleus speckle. Nucleus (GO:0005634);Nucleus (GO:0005634) 10557037/11568182,11313276 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota MECP2 HGNC:6990 methyl CpG binding protein 2 (Rett syndrome) P51608 Nucleus. Note=Colocalized with methyl-CpG in the genome. Nucleus (GO:0005634) 9620804,15696166,19059367 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi NA MECR HGNC:19691 mitochondrial trans-2-enoyl-CoA reductase Q9BV79 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12654921,9795230 mitochondrion 100 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms MED1 HGNC:9234 mediator complex subunit 1 Q15648 Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. Nucleus (GO:0005634); Kinetochore (GO:0000776) 12101254,11780067 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa MED10 HGNC:28760 mediator complex subunit 10 Q9BTT4 Nucleus (Probable). Cytoplasm (GO:0005737) 15334068 nucleus 30 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota MED11 HGNC:32687 mediator complex subunit 11 Q9P086 Nucleus (Probable). nucleus 46 0 nucleus nucleus Theria Bilateria Metazoa MED12 HGNC:11957 mediator complex subunit 12 Q93074 Nucleus (Probable). Nucleus (GO:0005634) 10198638,17081983 nucleus 31 2 nucleus nucleus Bilateria Bilateria Eukaryota MED12L HGNC:16050 mediator complex subunit 12-like Q86YW9 Nucleus (Probable). nucleus 31 2 nucleus nucleus Bilateria Bilateria Eukaryota MED13 HGNC:22474 mediator complex subunit 13 Q9UHV7 Nucleus. Nucleus (GO:0005634) 10235267,17081983 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota MED13L HGNC:22962 mediator complex subunit 13-like Q71F56 Nucleus (Probable). nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota MED14 HGNC:2370 mediator complex subunit 14 O60244 Nucleus (Probable). Nucleus (GO:0005634) 8710870,17081983 nucleus 24 0 nucleus nucleus Bilateria Bilateria Eukaryota MED15 HGNC:14248 mediator complex subunit 15 Q96RN5 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleoplasm (GO:0005654); Nucleolus (GO:0005730) 11024300,11024300,16904669,16904669 nucleus 30 0 cytoplasm. nucleus multiple Chordata Bilateria Opisthokonta MED16 HGNC:17556 mediator complex subunit 16 Q9Y2X0 Nucleus (Probable). Nucleus (GO:0005634) 10235266 nucleus 46 0 nucleus nucleus Deuterostomia Bilateria Holozoa MED17 HGNC:2375 mediator complex subunit 17 Q9NVC6 Nucleus (Probable). Nucleus (GO:0005634) 10198638 nucleus 31 0 nucleus nucleus Bilateria Bilateria Holozoa MED18 HGNC:25944 mediator complex subunit 18 Q9BUE0 Nucleus (Probable). mitochondrion 12 0 nucleus nucleus Bilateria Eukaryota Eukaryota MED19 HGNC:29600 mediator complex subunit 19 A0JLT2 Nucleus (Probable). Nucleus (GO:0005634) 17081983 nucleus 95 0 nucleus nucleus Bilateria Bilateria Holozoa MED20 HGNC:16840 mediator complex subunit 20 Q9H944 Nucleus (Probable). cytoplasm 25 0 nucleus nucleus Euteleostomi Bilateria Eukaryota MED21 HGNC:11473 mediator complex subunit 21 Q13503 Nucleus (Probable). Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) 9734358,15635413,11780067 nucleus 9 0 nucleus nucleus Bilateria Bilateria Eukaryota MED22 HGNC:11477 mediator complex subunit 22 Q15528 Nucleus (Probable). Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11891058/8586415,11891058,11891058 nucleus 78 0 cytoplasm. nucleus multiple Bilateria Eukaryota NA MED23 HGNC:2372 mediator complex subunit 23 Q9ULK4 Nucleus (Probable). Nucleus (GO:0005634) 11934987 nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota MED24 HGNC:22963 mediator complex subunit 24 O75448 Nucleus (Probable). Nucleus (GO:0005634) 10406464 nucleus 76 3 nucleus nucleus Deuterostomia Bilateria Eukaryota MED25 HGNC:28845 mediator complex subunit 25 Q71SY5 Nucleus. Nucleus (GO:0005634) 14983011 nucleus 100 0 nucleus nucleus Mammalia Deuterostomia Eukaryota MED26 HGNC:2376 mediator complex subunit 26 O95402 Nucleus (Probable). Nucleus (GO:0005634) 9989412,17081983 nucleus 17 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa MED27 HGNC:2377 mediator complex subunit 27 Q6P2C8 Nucleus. Nucleus (GO:0005634) 1020353 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota MED28 HGNC:24628 mediator complex subunit 28 Q9H204 Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. Nucleus (GO:0005634); Cytoskeleton (GO:0005856) ,16899217 nucleus 74 0 cytoplasm. nucleus multiple Mammalia Bilateria Eumetazoa MED29 HGNC:23074 mediator complex subunit 29 Q9NX70 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15555573,15555573 nucleus 100 0 cytoplasm. nucleus multiple Theria Bilateria Eumetazoa MED30 HGNC:23032 mediator complex subunit 30 Q96HR3 Nucleus (Probable). Nucleus (GO:0005634) 11909976 nucleus 57 0 nucleus nucleus Deuterostomia Bilateria Eumetazoa MED31 HGNC:24260 mediator complex subunit 31 Q9Y3C7 Nucleus (Probable). nucleus 30 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MED4 HGNC:17903 mediator complex subunit 4 Q9NPJ6 Nucleus. Nucleus (GO:0005634) 10235267 nucleus 100 0 nucleus nucleus Bilateria Bilateria Holozoa MED6 HGNC:19970 mediator complex subunit 6 O75586 Nucleus. Nucleus (GO:0005634) 9234719 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MED7 HGNC:2378 mediator complex subunit 7 O43513 Nucleus. Nucleus (GO:0005634) 9989412 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MED8 HGNC:19971 mediator complex subunit 8 Q96G25 Nucleus (Probable). Nucleus (GO:0005634); Extracellular (GO:0005576) 14576168,12149480,16188874 nucleus 56 0 nucleus. secreted multiple Bilateria Bilateria Holozoa MED9 HGNC:25487 mediator complex subunit 9 Q9NWA0 Nucleus (Probable). Nucleus (GO:0005634) 14638676 secreted 36 0 nucleus nucleus Euteleostomi Bilateria Bilateria MEDAG HGNC:25926 mesenteric estrogen-dependent adipogenesis Q5VYS4 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Euteleostomi Craniata MEF2A HGNC:6993 myocyte enhancer factor 2A Q02078 Nucleus. Nucleus (GO:0005634) ,1516833,9430690, nucleus 100 1 nucleus nucleus Deuterostomia Bilateria Eukaryota MEF2B HGNC:6995 myocyte enhancer factor 2B Q02080 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) ,9430690,/9430690 nucleus 100 1 nucleus nucleus NA NA Eukaryota MEF2BNB HGNC:37247 MEF2B neighbor Q96FH0 nucleus 41 0 nucleus nucleus NA NA Eukaryota MEF2C HGNC:6996 myocyte enhancer factor 2C Q06413 Nucleus. Nucleus (GO:0005634) ,11744164,9430690, nucleus 100 1 nucleus nucleus Euteleostomi Opisthokonta Eukaryota MEF2D HGNC:6997 myocyte enhancer factor 2D Q14814 Nucleus. Note=Translocated by HDAC4 to nuclear dots. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,8798771,8269842,9430690,,17081983 nucleus 100 1 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota MEFV HGNC:6998 Mediterranean fever O15553 Isoform 1: Cytoplasm, cytoskeleton. Isoform 2: Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 10666224,10666224,10666224 cytoplasm 42 0 cytoplasm. golgi apparatus. nucleus multiple Theria Theria Opisthokonta MEGF10 HGNC:29634 multiple EGF-like-domains 10 Q96KG7 Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup. Note=Enriched at the sites of contact with apoptotic thymocyte cells (By similarity). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11. plasma membrane 54 1 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota MEGF11 HGNC:29635 multiple EGF-like-domains 11 A6BM72 Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10. plasma membrane 100 1 plasma membrane plasma membrane Bilateria Eukaryota NA MEGF6 HGNC:3232 multiple EGF-like-domains 6 O75095 Secreted (Potential). secreted 32 0 secreted secreted Bilateria Eukaryota Eukaryota MEGF8 HGNC:3233 multiple EGF-like-domains 8 Q7Z7M0 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9693030 secreted 30 1 plasma membrane plasma membrane Theria Bilateria Cell.Organisms MEGF9 HGNC:3234 multiple EGF-like-domains 9 Q9H1U4 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 26 1 nucleus nucleus Amniota Euteleostomi Eukaryota MEI1 HGNC:28613 meiosis inhibitor 1 Q5TIA1 nucleus 6 4 nucleus nucleus Tetrapoda Deuterostomia Metazoa MEIG1 HGNC:23429 meiosis/spermiogenesis associated 1 Q5JSS6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15328412,10642798,8049060 nucleus 8 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa MEIOB HGNC:28569 meiosis specific with OB domains Q8N635 Cytoplasm (By similarity). cytoplasm 82 0 cytoplasm cytoplasm Amniota Bilateria Holozoa MEIS1 HGNC:7000 Meis homeobox 1 O00470 Nucleus (By similarity). Nucleus (GO:0005634) 10082572,17000644 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota MEIS2 HGNC:7001 Meis homeobox 2 O14770 Nucleus (By similarity). Nucleus (GO:0005634) 10764806 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota MEIS3 HGNC:29537 Meis homeobox 3 Q99687 Nucleus (Probable). Nucleus (GO:0005634) nucleus 66 0 nucleus nucleus NA NA Eukaryota MELK HGNC:16870 maternal embryonic leucine zipper kinase Q14680 Cell membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11802789,17081983,17081983 cytoplasm 26 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms MEMO1 HGNC:14014 mediator of cell motility 1 Q9Y316 cytoplasm 50 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms MEN1 HGNC:7010 multiple endocrine neoplasia I O00255 Nucleus. Note=Concentrated in nuclear body- like structures. Relocates to the nuclear matrix upon gamma irradiation. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Chromosome (GO:0005694); Nuclear matrix (GO:0016363) 9465067,15199122,12874027,9465067,9465067,14508515,12874027,12874027 nucleus 100 2 cytoplasm. nucleus. plasma membrane multiple Deuterostomia Bilateria Eumetazoa MEOX1 HGNC:7013 mesenchyme homeobox 1 P50221 Nucleus (Potential). Nucleus (GO:0005634) nucleus 55 0 nucleus nucleus Theria Euteleostomi Eukaryota MEOX2 HGNC:7014 mesenchyme homeobox 2 P50222 Nucleus. Nucleus speckle. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota MEP1A HGNC:7015 meprin A, alpha (PABA peptide hydrolase) Q16819 Membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9914532,8660687,12556482,11267665 secreted 39 1 plasma membrane. secreted multiple Chordata Bilateria Cell.Organisms MEP1B HGNC:7020 meprin A, beta Q16820 Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8660687,12556482,11267665,12941954 plasma membrane 72 1 plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms MEPCE HGNC:20247 methylphosphate capping enzyme Q7L2J0 cytoplasm 15 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota MEPE HGNC:13361 matrix extracellular phosphoglycoprotein Q9NQ76 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) secreted 100 0 secreted secreted Theria Theria Mammalia MERTK HGNC:7027 c-mer proto-oncogene tyrosine kinase Q12866 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 31 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms MESDC1 HGNC:13519 mesoderm development candidate 1 Q9H1K6 mitochondrion 20 1 mitochondrion mitochondrion Tetrapoda Deuterostomia Opisthokonta MESDC2 HGNC:13520 mesoderm development candidate 2 Q14696 Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783) 12581525 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Holozoa MESP1 HGNC:29658 mesoderm posterior 1 homolog (mouse) Q9BRJ9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Theria Bilateria Eumetazoa MESP2 HGNC:29659 mesoderm posterior 2 homolog (mouse) Q0VG99 Nucleus (By similarity). Nucleus (GO:0005634) 16996494 nucleus 54 0 nucleus nucleus Theria Amniota Eumetazoa MEST HGNC:7028 mesoderm specific transcript Q5EB52 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cytoplasm (GO:0005737) endoplasmic reticulum membrane 97 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Cell.Organisms NA MET HGNC:7029 met proto-oncogene P08581 Membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 2819873,15167892,18495663 plasma membrane 27 1 cytoplasm. plasma membrane. secreted multiple Deuterostomia Bilateria Cell.Organisms METAP1 HGNC:15789 methionyl aminopeptidase 1 P53582 Cytoplasm (By similarity). Nucleolus (GO:0005730) 15635413 cytoplasm 50 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms METAP1D HGNC:32583 methionyl aminopeptidase type 1D (mitochondrial) Q6UB28 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Eukaryota Cell.Organisms METAP2 HGNC:16672 methionyl aminopeptidase 2 P50579 Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms METRN HGNC:14151 meteorin, glial cell differentiation regulator Q9UJH8 Secreted (By similarity). Extracellular (GO:0005576) 15085178 secreted 77 0 secreted secreted Human Human Bilateria METRNL HGNC:27584 meteorin, glial cell differentiation regulator-like Q641Q3 Secreted (Potential). secreted 38 0 secreted secreted Euteleostomi Deuterostomia Eumetazoa METTL1 HGNC:7030 methyltransferase like 1 Q9UBP6 Nucleus. nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms METTL10 HGNC:33787 methyltransferase like 10 Q5JPI9 cytoplasm 25 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms METTL11B HGNC:31932 methyltransferase like 11B Q5VVY1 nucleus 39 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms METTL12 HGNC:33113 methyltransferase like 12 A8MUP2 Mitochondrion (Potential). nucleus 10 0 nucleus nucleus Homininae Eukaryota Eukaryota METTL13 HGNC:24248 methyltransferase like 13 Q8N6R0 cytoplasm 50 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms METTL14 HGNC:29330 methyltransferase like 14 Q9HCE5 nucleus 19 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota METTL15 HGNC:26606 methyltransferase like 15 A6NJ78 cytoplasm 56 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms METTL16 HGNC:28484 methyltransferase like 16 Q86W50 nucleus 61 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms METTL17 HGNC:19280 methyltransferase like 17 Q9H7H0 Mitochondrion (By similarity). nucleus 20 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms METTL18 HGNC:28793 methyltransferase like 18 O95568 cytoplasm 28 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms METTL20 HGNC:28739 methyltransferase like 20 Q8IXQ9 Cytoplasm. Note=Concentrated in cytoplasmic granular foci. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms METTL21A HGNC:30476 methyltransferase like 21A Q8WXB1 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms METTL21B HGNC:24936 methyltransferase like 21B Q96AZ1 Membrane; Multi-pass membrane protein (Potential). cytoplasm 100 2 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms METTL21C HGNC:33717 methyltransferase like 21C Q5VZV1 Nucleus. nucleus 100 0 nucleus nucleus Amniota Eukaryota Cell.Organisms METTL22 HGNC:28368 methyltransferase like 22 Q9BUU2 Nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms METTL23 HGNC:26988 methyltransferase like 23 Q86XA0 Membrane; Single-pass membrane protein (Potential). nucleus 17 1 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms METTL24 HGNC:21566 methyltransferase like 24 Q5JXM2 Secreted (Potential). secreted 80 0 secreted secreted Chordata Chordata Cell.Organisms METTL25 HGNC:26228 methyltransferase like 25 Q8N6Q8 nucleus 23 0 nucleus nucleus Chordata Eukaryota Cell.Organisms METTL2A HGNC:25755 methyltransferase like 2A Q96IZ6 cytoplasm 33 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms METTL2B HGNC:18272 methyltransferase like 2B Q6P1Q9 cytoplasm 33 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms METTL3 HGNC:17563 methyltransferase like 3 Q86U44 Nucleus speckle. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components. Nucleus (GO:0005634) 9409616 nucleus 100 0 nucleus nucleus Theria Eukaryota Cell.Organisms METTL4 HGNC:24726 methyltransferase like 4 Q8N3J2 cytoplasm 17 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms METTL5 HGNC:25006 methyltransferase like 5 Q9NRN9 cytoplasm 29 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms METTL6 HGNC:28343 methyltransferase like 6 Q8TCB7 cytoplasm 25 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota METTL7A HGNC:24550 methyltransferase like 7A Q9H8H3 Lipid droplet. Endoplasmic reticulum. Membrane. cytoplasm 17 0 endoplasmic reticulum. lipid droplet multiple Euteleostomi Cell.Organisms Cell.Organisms METTL7B HGNC:28276 methyltransferase like 7B Q6UX53 cytoplasm 16 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms METTL8 HGNC:25856 methyltransferase like 8 Q9H825 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 23 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms METTL9 HGNC:24586 methyltransferase like 9 Q9H1A3 Nucleus (GO:0005634) 17081983 cytoplasm 10 1 nucleus nucleus Bilateria Eukaryota Cell.Organisms MEX3A HGNC:33482 mex-3 RNA binding family member A A1L020 Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17267406,17267406 cytoplasm 39 0 cytoplasm. nucleus multiple NA NA Metazoa MEX3B HGNC:25297 mex-3 RNA binding family member B Q6ZN04 Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14- 3-3. cytoplasm 23 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota MEX3C HGNC:28040 mex-3 RNA binding family member C Q5U5Q3 Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. cytoplasm 27 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota MEX3D HGNC:16734 mex-3 RNA binding family member D Q86XN8 Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Perinuclear region (GO:0048471) 14769789,14769789,14769789 cytoplasm 23 0 cytoplasm. nucleus multiple Amniota Amniota Eukaryota MFAP1 HGNC:7032 microfibrillar-associated protein 1 P55081 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7835894,17081983,17081983 secreted 100 0 cytoplasm. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota MFAP2 HGNC:7033 microfibrillar-associated protein 2 P55001 Secreted, extracellular space, extracellular matrix. Extracellular matrix (GO:0005578);Extracellular (GO:0005576) 11796718/11284693,3015971,11796718 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata MFAP3 HGNC:7034 microfibrillar-associated protein 3 P55082 Cell membrane; Single-pass type I membrane protein (Potential). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 7782085, plasma membrane 44 1 secreted secreted Tetrapoda Tetrapoda Craniata MFAP3L HGNC:29083 microfibrillar-associated protein 3-like O75121 Cell membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 26 1 secreted secreted Human Euteleostomi Bilateria MFAP4 HGNC:7035 microfibrillar-associated protein 4 P55083 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 10542261 secreted 100 0 secreted secreted Theria Tetrapoda Cell.Organisms MFAP5 HGNC:29673 microfibrillar associated protein 5 Q13361 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8557636 secreted 100 0 secreted secreted Theria Amniota Craniata MFF HGNC:24858 mitochondrial fission factor Q9GZY8 Mitochondrion outer membrane; Single-pass type IV membrane protein. Integral to membrane (GO:0016021); Mitochondrion (GO:0005739) ,15598749 mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Tetrapoda Bilateria Bilateria MFGE8 HGNC:7036 milk fat globule-EGF factor 8 protein Q08431 Membrane; Peripheral membrane protein. Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11856354,9260929,12000961,11856354 secreted 54 0 secreted secreted Homininae Deuterostomia Eukaryota MFHAS1 HGNC:16982 malignant fibrous histiocytoma amplified sequence 1 Q9Y4C4 secreted 19 0 secreted secreted Tetrapoda Cell.Organisms Cell.Organisms MFI2 HGNC:7037 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 P08582 Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10691965,8705293,11852110 secreted 31 0 secreted secreted Deuterostomia Bilateria Eukaryota MFN1 HGNC:18262 mitofusin 1 Q8IWA4 Mitochondrion outer membrane; Multi-pass membrane protein (Probable). Isoform 2: Cytoplasm. Mitochondrion (GO:0005739) 12759376,11181170 mitochondrion membrane 88 1 cytoplasm. mitochondrion. mitochondrion membrane multiple Bilateria Bilateria Cell.Organisms MFN2 HGNC:16877 mitofusin 2 O95140 Mitochondrion outer membrane; Multi-pass membrane protein. Note=Colocalizes with BAX during apoptosis. Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrial membrane (GO:0005740) 11950885,11950885,11950885,17035996 mitochondrion membrane 100 1 cytoplasm. endoplasmic reticulum. mitochondrion. mitochondrion membrane multiple Bilateria Bilateria Cell.Organisms MFNG HGNC:7038 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase O00587 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Extracellular (GO:0005576) 9187150 golgi apparatus membrane 34 0 secreted secreted Amniota Euteleostomi Holozoa MFRP HGNC:18121 membrane frizzled-related protein Q9BY79 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 11263980 plasma membrane 17 1 plasma membrane plasma membrane NA NA Metazoa MFSD1 HGNC:25874 major facilitator superfamily domain containing 1 Q9H3U5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 30 11 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms MFSD10 HGNC:16894 major facilitator superfamily domain containing 10 Q14728 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 9 12 vacuole membrane vacuole membrane Bilateria Cell.Organisms Cell.Organisms MFSD11 HGNC:25458 major facilitator superfamily domain containing 11 O43934 Membrane; Multi-pass membrane protein (Potential). plasma membrane 9 12 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota MFSD12 HGNC:28299 major facilitator superfamily domain containing 12 Q6NUT3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 6 11 golgi apparatus membrane golgi apparatus membrane Chordata Eukaryota Cell.Organisms MFSD2A HGNC:25897 major facilitator superfamily domain containing 2A Q8NA29 Cell membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane (By similarity); Multi-pass membrane protein (Potential). Note=Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane. Nucleus (GO:0005634) 17081983 plasma membrane 23 12 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms MFSD2B HGNC:37207 major facilitator superfamily domain containing 2B A6NFX1 Membrane; Multi-pass membrane protein (Potential). plasma membrane 11 12 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms MFSD3 HGNC:25157 major facilitator superfamily domain containing 3 Q96ES6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 25 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Deuterostomia Cell.Organisms MFSD4 HGNC:25433 major facilitator superfamily domain containing 4 Q8N468 Membrane; Multi-pass membrane protein (Potential). plasma membrane 12 12 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota MFSD5 HGNC:28156 major facilitator superfamily domain containing 5 Q6N075 Membrane; Multi-pass membrane protein (Potential). plasma membrane 20 11 plasma membrane plasma membrane Theria Eukaryota Eukaryota MFSD6 HGNC:24711 major facilitator superfamily domain containing 6 Q6ZSS7 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 31 12 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms MFSD6L HGNC:26656 major facilitator superfamily domain containing 6-like Q8IWD5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 36 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Deuterostomia Eukaryota MFSD7 HGNC:26177 major facilitator superfamily domain containing 7 Q6UXD7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 10 12 plasma membrane plasma membrane Deuterostomia Opisthokonta Cell.Organisms MFSD8 HGNC:28486 major facilitator superfamily domain containing 8 Q8NHS3 Lysosome membrane; Multi-pass membrane protein. Note=Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs. Lysosome (GO:0005764); Cytoplasm (GO:0005737) 17564970,17564970 vacuole membrane 11 12 cytoplasm. lysosome. lysosome membrane multiple Euteleostomi Eukaryota Cell.Organisms MFSD9 HGNC:28158 major facilitator superfamily domain containing 9 Q8NBP5 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 15 10 vacuole membrane vacuole membrane Deuterostomia Opisthokonta Cell.Organisms MGA HGNC:14010 MGA, MAX dimerization protein Q8IWI9 Nucleus (Probable). Nucleus (GO:0005634) 11602341,10601024 nucleus 40 0 nucleus nucleus Tetrapoda Euteleostomi Holozoa MGAM HGNC:7043 maltase-glucoamylase (alpha-glucosidase) O43451 Apical cell membrane; Single-pass type II membrane protein. Note=Brush border. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 3143729,15598749 plasma membrane 100 1 mitochondrion. plasma membrane multiple NA NA NA MGARP HGNC:29969 mitochondria-localized glutamic acid-rich protein Q8TDB4 Membrane; Single-pass membrane protein (Potential). Mitochondrion. Mitochondrion outer membrane; Single- pass type IV membrane protein; Cytoplasmic side (By similarity). Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion (By similarity). Integral to membrane (GO:0016021) secreted 49 1 mitochondrion mitochondrion Amniota Amniota Euteleostomi MGAT1 HGNC:7044 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase P26572 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 9020882 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Theria Eukaryota Eukaryota MGAT2 HGNC:7045 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Q10469 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 7635144,7797505 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Eukaryota MGAT3 HGNC:7046 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase Q09327 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 12716887 golgi apparatus membrane 100 0 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Eukaryota Cell.Organisms MGAT4A HGNC:7047 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A Q9UM21 Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A: Golgi apparatus membrane; Single- pass type II membrane protein (By similarity). Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A soluble form: Secreted (By similarity). Golgi apparatus (GO:0005794) 10024668 secreted 9 0 golgi apparatus golgi apparatus Deuterostomia Bilateria Opisthokonta MGAT4B HGNC:7048 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B Q9UQ53 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). cytoplasm 2 0 cytoplasm cytoplasm Deuterostomia Bilateria Opisthokonta MGAT4C HGNC:30871 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) Q9UBM8 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). secreted 9 1 secreted secreted Euteleostomi Deuterostomia Opisthokonta MGAT5 HGNC:7049 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase Q09328 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 10700233,10580127,11872751 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. secreted multiple Deuterostomia Bilateria Holozoa MGAT5B HGNC:24140 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B Q3V5L5 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 89 1 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Opisthokonta MGEA5 HGNC:7056 meningioma expressed antigen 5 (hyaluronidase) O60502 Isoform 3: Nucleus. Isoform 1: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Integral to membrane (GO:0016021) 11341771,11148210,11341771,11148210,11341771 cytoplasm 64 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms MGLL HGNC:17038 monoglyceride lipase Q99685 mitochondrion 34 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MGME1 HGNC:16205 mitochondrial genome maintenance exonuclease 1 Q9BQP7 Mitochondrion. Mitochondrion (GO:0005739) 15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms MGMT HGNC:7059 O-6-methylguanine-DNA methyltransferase P16455 Nucleus. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 1384961,8612308,11564893,8612308 nucleus 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euarchontoglires Cell.Organisms Cell.Organisms MGP HGNC:7060 matrix Gla protein P08493 Secreted. Extracellular (GO:0005576) 9916809 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Craniata MGRN1 HGNC:20254 mahogunin ring finger 1, E3 ubiquitin protein ligase O60291 Early endosome. Isoform 1: Cytoplasm, cytosol. Nucleus. Isoform 2: Cytoplasm, cytosol. Nucleus. Isoform 3: Cytoplasm, cytosol. Cell membrane. Isoform 4: Cytoplasm, cytosol. Cell membrane. cytoplasm 34 0 cytoplasm. endosome. nucleus multiple Euteleostomi Eukaryota Eukaryota MGST1 HGNC:7061 microsomal glutathione S-transferase 1 P10620 Microsome (By similarity). Mitochondrion outer membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Nuclear membrane (GO:0005635) 11034337,11034337,11034337 endoplasmic reticulum membrane 59 4 endoplasmic reticulum. nucleus membrane multiple Deuterostomia Cell.Organisms Cell.Organisms MGST2 HGNC:7063 microsomal glutathione S-transferase 2 Q99735 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Microsome membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 8703034 endoplasmic reticulum membrane 21 2 endoplasmic reticulum endoplasmic reticulum Amniota Cell.Organisms Cell.Organisms MGST3 HGNC:7064 microsomal glutathione S-transferase 3 O14880 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Microsome membrane; Multi-pass membrane protein (Potential). Microsome membrane; Lipid-anchor (Potential). Endoplasmic reticulum (GO:0005783); Cytosol (GO:0005829) 9278457,15561729 mitochondrion membrane 23 4 cytoplasm. endoplasmic reticulum multiple Deuterostomia Eukaryota Cell.Organisms MIA HGNC:7076 melanoma inhibitory activity Q16674 Secreted. Extracellular (GO:0005576) 11331761 secreted 100 0 secreted secreted NA NA Bilateria MIA2 HGNC:18432 melanoma inhibitory activity 2 Q96PC5 Secreted (Potential). secreted 19 0 secreted secreted Euarchontoglires Tetrapoda Bilateria MIA3 HGNC:24008 melanoma inhibitory activity family, member 3 Q5JRA6 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane. endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Metazoa MIB1 HGNC:21086 mindbomb E3 ubiquitin protein ligase 1 Q86YT6 Cytoplasm. Cell membrane (By similarity). Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Vesicle (None) 16857196 golgi apparatus 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms MIB2 HGNC:30577 mindbomb E3 ubiquitin protein ligase 2 Q96AX9 Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14507647,17081983 cytoplasm 35 0 cytoplasm. endosome. nucleus multiple Deuterostomia Bilateria Cell.Organisms MICA HGNC:7090 MHC class I polypeptide-related sequence A Q29983 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. Integral to membrane (GO:0016021) secreted 11 1 cytoplasm. plasma membrane multiple Euarchontoglires Eutheria NA MICAL1 HGNC:20619 microtubule associated monooxygenase, calponin and LIM domain containing 1 Q8TDZ2 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 11827972,17081983 cytoplasm 100 2 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota MICAL2 HGNC:24693 microtubule associated monooxygenase, calponin and LIM domain containing 2 O94851 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). cytoplasm 62 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota MICAL3 HGNC:24694 microtubule associated monooxygenase, calponin and LIM domain containing 3 Q7RTP6 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Microtubule (GO:0005874) 15694364,15694364 cytoplasm 100 0 cytoplasm cytoplasm NA NA Eukaryota MICALCL HGNC:25933 MICAL C-terminal like Q6ZW33 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12110185 cytoplasm 56 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa MICALL1 HGNC:29804 MICAL-like 1 Q8N3F8 Cytoplasm, cytoskeleton (By similarity). cytoplasm 31 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota MICALL2 HGNC:29672 MICAL-like 2 Q8IY33 Cytoplasm, cytoskeleton (By similarity). cytoplasm 32 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota MICB HGNC:7091 MHC class I polypeptide-related sequence B Q29980 Cell membrane; Single-pass type I membrane protein (By similarity). Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 12594848,12682252,11491531 secreted 12 1 endoplasmic reticulum. plasma membrane multiple Euarchontoglires Eutheria NA MICU1 HGNC:1530 mitochondrial calcium uptake 1 Q9BPX6 Mitochondrion inner membrane; Single-pass membrane protein. Extracellular (GO:0005576) mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota MICU2 HGNC:31830 mitochondrial calcium uptake 2 Q8IYU8 Mitochondrion (By similarity). Cytoskeleton (GO:0005856) 11124993 mitochondrion 84 1 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota MICU3 HGNC:27820 mitochondrial calcium uptake family, member 3 Q86XE3 Mitochondrion (By similarity). Membrane; Single-pass membrane protein (Potential). mitochondrion 36 1 mitochondrion mitochondrion Chordata Bilateria Eukaryota MID1 HGNC:7095 midline 1 (Opitz/BBB syndrome) O15344 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co- localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis. Microtubule (GO:0005874); Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874);Microtubule (GO:0005874); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11030761,11030761,11030761,17081983/10400985,10400985,11685209,15070402,11371618,10400985,11685209,15070402/11030761,11030761,11030761 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota MID1IP1 HGNC:20715 MID1 interacting protein 1 Q9NPA3 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with microtubules (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15070402,15070402 secreted 15 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Bilateria MID2 HGNC:7096 midline 2 Q9UJV3 Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. Cytoplasm (GO:0005737) 10400986,11806752 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eukaryota MIDN HGNC:16298 midnolin Q504T8 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 10974535 cytoplasm 24 0 nucleus nucleus Theria Bilateria Metazoa MIEF1 HGNC:25979 mitochondrial elongation factor 1 Q9NQG6 Mitochondrion outer membrane; Single-pass membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Eumetazoa MIEF2 HGNC:17920 mitochondrial elongation factor 2 Q96C03 Mitochondrion outer membrane; Single-pass membrane protein. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria. Integral to membrane (GO:0016021) mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Tetrapoda Tetrapoda Chordata MIEN1 HGNC:28230 migration and invasion enhancer 1 Q9BRT3 Cytoplasm, cytosol. Cell membrane; Lipid- anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions. cytoplasm 21 0 cytoplasm cytoplasm Theria Bilateria Cell.Organisms MIER1 HGNC:29657 mesoderm induction early response 1, transcriptional regulator Q8N108 Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Cytoplasm. Isoform 5: Cytoplasm. Isoform 6: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 12242014,17081983,12242014,17081983/17081983 nucleus 69 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota MIER2 HGNC:29210 mesoderm induction early response 1, family member 2 Q8N344 Nucleus (By similarity). nucleus 30 0 nucleus nucleus Theria Amniota Opisthokonta MIER3 HGNC:26678 mesoderm induction early response 1, family member 3 Q7Z3K6 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta MIF HGNC:7097 macrophage migration inhibitory factor (glycosylation-inhibiting factor) P14174 Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9006339,11089976 secreted 28 0 cytoplasm. secreted multiple NA NA Cell.Organisms MIF4GD HGNC:24030 MIF4G domain containing A9UHW6 Cytoplasm. Nucleus. cytoplasm 19 0 cytoplasm. nucleus multiple Chordata Bilateria Metazoa MIIP HGNC:25715 migration and invasion inhibitory protein Q5JXC2 nucleus 84 0 nucleus nucleus Amniota Amniota Holozoa MILR1 HGNC:27570 mast cell immunoglobulin-like receptor 1 Q7Z6M3 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane NA NA NA MINA HGNC:19441 MYC induced nuclear antigen Q8IUF8 Nucleus. Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 14695334,12091391,14695334,12091391 nucleus 100 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms MINK1 HGNC:17565 misshapen-like kinase 1 Q8N4C8 Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Isoform 4: Golgi apparatus. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15469942,15469942/17081983,17081983 cytoplasm 55 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms MINOS1 HGNC:32068 mitochondrial inner membrane organizing system 1 Q5TGZ0 Mitochondrion inner membrane; Single-pass membrane protein. Note=The C-terminus is located in the intermembrane space (By similarity), while the location of the N- terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Amniota Opisthokonta Eukaryota MINPP1 HGNC:7102 multiple inositol-polyphosphate phosphatase 1 Q9UNW1 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 9472008,10938126 endoplasmic reticulum 81 0 cytoplasm. endoplasmic reticulum multiple Euteleostomi Cell.Organisms Cell.Organisms MIOS HGNC:21905 missing oocyte, meiosis regulator, homolog (Drosophila) Q9NXC5 nucleus 21 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MIOX HGNC:14522 myo-inositol oxygenase Q9UGB7 Cytoplasm (By similarity). cytoplasm 86 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms MIP HGNC:7103 major intrinsic protein of lens fiber P30301 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Plasma membrane (GO:0005886) 1840563,1505237 vacuole membrane 26 6 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms MIPEP HGNC:7104 mitochondrial intermediate peptidase Q99797 Mitochondrion matrix. Mitochondrion (GO:0005739) 9073519 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms MIPOL1 HGNC:21460 mirror-image polydactyly 1 Q8TD10 cytoplasm 13 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa MIS12 HGNC:24967 MIS12 kinetochore complex component Q9H081 Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. Kinetochore (GO:0000776); Nucleus (GO:0005634) 15824131,15561729,12515822 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa MIS18A HGNC:1286 MIS18 kinetochore protein A Q9NYP9 Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. nucleus 100 0 nucleus nucleus Eutheria Opisthokonta Eukaryota MIS18BP1 HGNC:20190 MIS18 binding protein 1 Q6P0N0 Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. Nucleus (GO:0005634);Nucleus (GO:0005634) none,17081983/17081983 nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Holozoa MISP HGNC:27000 mitotic spindle positioning Q8IVT2 Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re- attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis. Nucleus (GO:0005634); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15561729,17081983,17081983 nucleus 69 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Euteleostomi MITD1 HGNC:25207 MIT, microtubule interacting and transport, domain containing 1 Q8WV92 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides. Late endosome (GO:0005770) 1673941 cytoplasm 29 0 endosome endosome Bilateria Bilateria Cell.Organisms MITF HGNC:7105 microphthalmia-associated transcription factor O75030 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7969144,11176068,9918847 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota MIXL1 HGNC:13363 Mix paired-like homeobox Q9H2W2 Nucleus. Nucleus (GO:0005634) 12070013 nucleus 100 0 nucleus nucleus Mammalia Mammalia Eukaryota MKI67 HGNC:7107 marker of proliferation Ki-67 P46013 Nucleus. Nucleus, nucleolus. Chromosome. Note=Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8227122,2571566,15635413,11790298,12485163,14659764,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Bilateria Cell.Organisms MKKS HGNC:7108 McKusick-Kaufman syndrome Q9NPJ1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome. cytoplasm 100 0 cytoplasm cytoplasm Amniota Deuterostomia Cell.Organisms MKL1 HGNC:14334 megakaryoblastic leukemia (translocation) 1 Q969V6 Cytoplasm (By similarity). Nucleus (By similarity). Note=Binding to globular actin is required to maintain cytoplasmic localization (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14970199,14970199,17081983 nucleus 29 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Opisthokonta MKL2 HGNC:29819 MKL/myocardin-like 2 Q9ULH7 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 28 0 nucleus nucleus Deuterostomia Opisthokonta Opisthokonta MKLN1 HGNC:7109 muskelin 1, intracellular mediator containing kelch motifs Q9UL63 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9724633,15084145,11006128,9724633,15084145,11006128 cytoplasm 99 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Cell.Organisms MKNK1 HGNC:7110 MAP kinase interacting serine/threonine kinase 1 Q9BUB5 Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15350534,15350534 nucleus 22 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms MKNK2 HGNC:7111 MAP kinase interacting serine/threonine kinase 2 Q9HBH9 Isoform 2: Nucleus, PML body. Isoform 1: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12897141,12897141 cytoplasm 18 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms MKRN1 HGNC:7112 makorin ring finger protein 1 Q9UHC7 nucleus 26 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota MKRN2 HGNC:7113 makorin ring finger protein 2 Q9H000 nucleus 31 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota MKRN3 HGNC:7114 makorin ring finger protein 3 Q13064 Nucleus (GO:0005634) nucleus 12 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota MKS1 HGNC:7121 Meckel syndrome, type 1 Q9NXB0 Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). Cytoplasm (GO:0005737); Centrosome (GO:0005813); Cell surface (GO:0009986) 17185389,17185389,17185389 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota MKX HGNC:23729 mohawk homeobox Q8IYA7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Tetrapoda Bilateria Eukaryota MLANA HGNC:7124 melan-A Q16655 Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. Plasma membrane (GO:0005886) secreted 58 1 endoplasmic reticulum membrane. golgi apparatus. melanosome multiple Tetrapoda Tetrapoda Euteleostomi MLC1 HGNC:17082 megalencephalic leukoencephalopathy with subcortical cysts 1 Q15049 Membrane; Multi-pass membrane protein (Potential). Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum. Plasma membrane (GO:0005886) 11254442 secreted 26 8 cytoplasm. endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Craniata MLEC HGNC:28973 malectin Q14165 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 84 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms MLF1 HGNC:7125 myeloid leukemia factor 1 P58340 Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12176995,15861129,12176995 cytoplasm 35 0 cytoplasm. nucleus multiple Amniota Euteleostomi Metazoa MLF2 HGNC:7126 myeloid leukemia factor 2 Q15773 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 23 0 nucleus nucleus Human Human Metazoa MLH1 HGNC:7127 mutL homolog 1 P40692 Nucleus. Nucleus (GO:0005634) 10928988,11691925 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms MLH3 HGNC:7128 mutL homolog 3 Q9UHC1 Nucleus (Potential). Nucleus (GO:0005634) 10615123 nucleus 15 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms MLIP HGNC:21355 muscular LMNA-interacting protein Q5VWP3 Nucleus (By similarity). Nucleus envelope (By similarity). Nucleus, PML body (By similarity). nucleus 68 0 nucleus nucleus Amniota Amniota Euteleostomi MLKL HGNC:26617 mixed lineage kinase domain-like Q8NB16 plasma membrane 10 0 n/a n/a Euarchontoglires Chordata Cell.Organisms MLLT1 HGNC:7134 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 Q03111 Nucleus. Nucleus (GO:0005634) 8080983,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota MLLT10 HGNC:16063 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 P55197 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10860745,11423977,11756182,11756182 nucleus 99 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota MLLT11 HGNC:16997 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 Q13015 nucleus 37 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi MLLT3 HGNC:7136 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 P42568 Nucleus (By similarity). Nucleus (GO:0005634) 11439343,14603337 nucleus 98 0 nucleus nucleus Chordata Chordata Eukaryota MLLT4 HGNC:7137 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 P55196 Cell junction, adherens junction. Note=Not found at cell-matrix AJs. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Basolateral membrane (GO:0016323) 9349501,17081983,9349501,17081983,9334353,15811349 secreted 100 2 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Opisthokonta MLLT6 HGNC:7138 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 P55198 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 nucleus 37 0 nucleus nucleus Human Deuterostomia Eukaryota MLN HGNC:7141 motilin P12872 Secreted. secreted 100 0 secreted secreted Amniota Amniota Amniota MLNR HGNC:4495 motilin receptor O43193 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11461914,10381885 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa MLPH HGNC:29643 melanophilin Q9BV36 Cytoplasm. Endosome (GO:0005768) 11856727 cytoplasm 100 0 cytoplasm. endosome multiple Amniota Euteleostomi Eumetazoa MLST8 HGNC:24825 MTOR associated protein, LST8 homolog (S. cerevisiae) Q9BVC4 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 11182770,11182770 cytoplasm 96 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms MLX HGNC:11645 MLX, MAX dimerization protein Q9UH92 Isoform Alpha: Cytoplasm. Isoform Beta: Cytoplasm. Isoform Gamma: Nucleus. Note=Found predominantly in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10918583,10918583/12446771,12446771/10918583,10918583 nucleus 22 0 cytoplasm. nucleus multiple Bilateria Bilateria Opisthokonta MLXIP HGNC:17055 MLX interacting protein Q9HAP2 Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11073985,12446771,11073985,12446771 nucleus 37 0 cytoplasm. nucleus multiple Chordata Bilateria Holozoa MLXIPL HGNC:12744 MLX interacting protein-like Q9NP71 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) /11724780,15163635,11698644,11724780,15163635,11698644 nucleus 100 0 cytoplasm. nucleus multiple Amniota Bilateria NA MLYCD HGNC:7150 malonyl-CoA decarboxylase O95822 Cytoplasm. Mitochondrion. Mitochondrion matrix (By similarity). Peroxisome. Peroxisome matrix (By similarity). Note=Enzymatically active in all three subcellular compartments (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Peroxisome (GO:0005777); Nucleus (GO:0005634) 4180063,456730,10455107,10455107,10417274,17081983 nucleus 28 0 cytoplasm. mitochondrion. nucleus. peroxisome multiple Euteleostomi Cell.Organisms Cell.Organisms MMAA HGNC:18871 methylmalonic aciduria (cobalamin deficiency) cblA type Q8IVH4 Mitochondrion (Probable). Mitochondrion (GO:0005739) 12438653 cytoplasm 34 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms MMAB HGNC:19331 methylmalonic aciduria (cobalamin deficiency) cblB type Q96EY8 Mitochondrion (Probable). Mitochondrion (GO:0005739) 12514191 mitochondrion 49 0 mitochondrion mitochondrion Amniota Cell.Organisms Cell.Organisms MMACHC HGNC:24525 methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria Q9Y4U1 nucleus 26 0 nucleus nucleus Euteleostomi Bilateria Metazoa MMADHC HGNC:25221 methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria Q9H3L0 Mitochondrion (Potential). secreted 29 0 secreted secreted Bilateria Cell.Organisms Eukaryota MMD HGNC:7153 monocyte to macrophage differentiation-associated Q15546 Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 7503749 golgi apparatus membrane 65 7 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms MMD2 HGNC:30133 monocyte to macrophage differentiation-associated 2 Q8IY49 Golgi apparatus membrane; Multi-pass membrane protein. golgi apparatus membrane 100 7 golgi apparatus membrane golgi apparatus membrane Bilateria Cell.Organisms Cell.Organisms MME HGNC:7154 membrane metallo-endopeptidase P08473 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Extracellular matrix (GO:0005578) 11367540,3162217,11170145,14968440,12150966,12485446,15217945,14550292,11170145,12485446,15100223,12102663,15100223,12102663,15100223,12485446 plasma membrane 100 1 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms MMEL1 HGNC:14668 membrane metallo-endopeptidase-like 1 Q495T6 Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists (By similarity). plasma membrane 45 1 secreted secreted Bilateria Bilateria Cell.Organisms MMGT1 HGNC:28100 membrane magnesium transporter 1 Q8N4V1 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein (By similarity). Early endosome membrane; Single-pass type I membrane protein (By similarity). Note=Detected in the Golgi apparatus and in post-Golgi vesicles including early endosomes (By similarity). endoplasmic reticulum membrane 39 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota NA MMP1 HGNC:7155 matrix metallopeptidase 1 (interstitial collagenase) P03956 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 7641497 secreted 34 0 secreted secreted Amniota Amniota Cell.Organisms MMP10 HGNC:7156 matrix metallopeptidase 10 (stromelysin 2) P09238 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 8003069 secreted 34 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms MMP11 HGNC:7157 matrix metallopeptidase 11 (stromelysin 3) P24347 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 11280785 secreted 32 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms MMP12 HGNC:7158 matrix metallopeptidase 12 (macrophage elastase) P39900 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 10949161 secreted 40 0 secreted secreted Theria Theria NA MMP13 HGNC:7159 matrix metallopeptidase 13 (collagenase 3) P45452 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 10949161 secreted 33 0 secreted secreted Euteleostomi Euteleostomi NA MMP14 HGNC:7160 matrix metallopeptidase 14 (membrane-inserted) P50281 Membrane; Single-pass type I membrane protein (Potential). Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10949161,8015608 secreted 26 1 cytoplasm. melanosome. plasma membrane. secreted multiple Bilateria Cell.Organisms Cell.Organisms MMP15 HGNC:7161 matrix metallopeptidase 15 (membrane-inserted) P51511 Membrane; Single-pass type I membrane protein; Extracellular side (Potential). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10949161,7649159 secreted 29 1 plasma membrane. secreted multiple Bilateria Cell.Organisms Cell.Organisms MMP16 HGNC:7162 matrix metallopeptidase 16 (membrane-inserted) P51512 Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential). Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10949161,7559440 secreted 27 1 plasma membrane. secreted multiple Bilateria Cell.Organisms Cell.Organisms MMP17 HGNC:7163 matrix metallopeptidase 17 (membrane-inserted) Q9ULZ9 Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10949161,10567400,10567400 secreted 23 1 plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms MMP19 HGNC:7165 matrix metallopeptidase 19 Q99542 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576); Cell surface (GO:0009986) 10949161,10419448,11801661 secreted 27 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms MMP2 HGNC:7166 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) P08253 Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Isoform 2: Cytoplasm. Mitochondrion. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12676736,9640131,9853262,11382769,9119036 endoplasmic reticulum membrane 33 0 cytoplasm. mitochondrion. nucleus. secreted multiple Chordata Chordata Cell.Organisms MMP20 HGNC:7167 matrix metallopeptidase 20 O60882 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10949161 secreted 86 0 secreted secreted Theria Eukaryota Cell.Organisms MMP21 HGNC:14357 matrix metallopeptidase 21 Q8N119 Secreted (Potential). Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12490321,12490321 secreted 23 0 cytoplasm. secreted multiple Mammalia Euteleostomi Cell.Organisms MMP23B HGNC:7171 matrix metallopeptidase 23B O75900 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist (Probable). Extracellular (GO:0005576) 10949161 secreted 30 1 secreted secreted Euteleostomi Euteleostomi Cell.Organisms MMP24 HGNC:7172 matrix metallopeptidase 24 (membrane-inserted) Q9Y5R2 Cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity). Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix (By similarity). Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage (By similarity). Plasma membrane (GO:0005886) 10363975 secreted 26 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms MMP25 HGNC:14246 matrix metallopeptidase 25 Q9NPA2 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Plasma membrane (GO:0005886); Extracellular matrix (GO:0005578) 10706098,11034316,10628838 secreted 21 1 plasma membrane. secreted multiple Human Bilateria Cell.Organisms MMP26 HGNC:14249 matrix metallopeptidase 26 Q9NRE1 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 10801841 secreted 100 0 secreted secreted Catarrhini Eutheria Cell.Organisms MMP27 HGNC:14250 matrix metallopeptidase 27 Q9H306 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) secreted 29 0 secreted secreted Theria Amniota Cell.Organisms MMP28 HGNC:14366 matrix metallopeptidase 28 Q9H239 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12164918,11121398,12164918 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Eumetazoa MMP3 HGNC:7173 matrix metallopeptidase 3 (stromelysin 1, progelatinase) P08254 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 8957070 secreted 35 0 secreted secreted Tetrapoda Tetrapoda NA MMP7 HGNC:7174 matrix metallopeptidase 7 (matrilysin, uterine) P09237 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576) 2253219 secreted 36 0 secreted secreted Amniota Amniota Cell.Organisms MMP8 HGNC:7175 matrix metallopeptidase 8 (neutrophil collagenase) P22894 Cytoplasmic granule. Secreted, extracellular space, extracellular matrix (Probable). Note=Stored in intracellular granules. Extracellular (GO:0005576) 10949161 secreted 33 0 secreted secreted Euarchontoglires Theria Cell.Organisms MMP9 HGNC:7176 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) P14780 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10988146,,11978564,17912438, endoplasmic reticulum membrane 34 0 secreted secreted Chordata Chordata Cell.Organisms MMRN1 HGNC:7178 multimerin 1 Q13201 Secreted (Potential). Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9454761,9454761,9454761 secreted 17 0 cytoplasm. secreted multiple Tetrapoda Tetrapoda Holozoa MMRN2 HGNC:19888 multimerin 2 Q9H8L6 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) secreted 100 0 secreted secreted Amniota Amniota Chordata MMS19 HGNC:13824 MMS19 nucleotide excision repair homolog (S. cerevisiae) Q96T76 Nucleus. Cytoplasm, cytoskeleton, spindle. Nucleus (GO:0005634) 11279242,11071939 nucleus 80 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota MMS22L HGNC:21475 MMS22-like, DNA repair protein Q6ZRQ5 Nucleus. Note=Localizes to DNA damage sites, accumulates at stressed replication forks. nucleus 100 2 nucleus nucleus Tetrapoda Deuterostomia Metazoa MN1 HGNC:7180 meningioma (disrupted in balanced translocation) 1 Q10571 secreted 12 0 secreted secreted Theria Euteleostomi Craniata MNAT1 HGNC:7181 MNAT CDK-activating kinase assembly factor 1 P51948 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12527756,8521818 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota MND1 HGNC:24839 meiotic nuclear divisions 1 homolog (S. cerevisiae) Q9BWT6 Nucleus (Probable). nucleus 31 0 nucleus nucleus Eukaryota Eukaryota Eukaryota MNDA HGNC:7183 myeloid cell nuclear differentiation antigen P41218 Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin. Nucleus (GO:0005634) 7512843 nucleus 42 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eutheria MNS1 HGNC:29636 meiosis-specific nuclear structural 1 Q8NEH6 Nucleus (By similarity). Nucleus (GO:0005634) 8032679 nucleus 72 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota MNT HGNC:7188 MAX network transcriptional repressor Q99583 Nucleus. Nucleus (GO:0005634) 9184233 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Opisthokonta MNX1 HGNC:4979 motor neuron and pancreas homeobox 1 P50219 Nucleus. Nucleus (GO:0005634) 11528505 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota MOAP1 HGNC:16658 modulator of apoptosis 1 Q96BY2 nucleus 48 0 nucleus nucleus Euarchontoglires Euarchontoglires Deuterostomia MOB1A HGNC:16015 MOB kinase activator 1A Q9H8S9 Cytoplasm (GO:0005737) 11319234 cytoplasm 47 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MOB1B HGNC:29801 MOB kinase activator 1B Q7L9L4 Cytoplasm. Nucleus. cytoplasm 45 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MOB2 HGNC:24904 MOB kinase activator 2 Q70IA6 Nucleus. Cytoplasm, perinuclear region. cytoplasm 26 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota MOB3A HGNC:29802 MOB kinase activator 3A Q96BX8 cytoplasm 33 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota MOB3B HGNC:23825 MOB kinase activator 3B Q86TA1 cytoplasm 34 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota MOB3C HGNC:29800 MOB kinase activator 3C Q70IA8 cytoplasm 31 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota MOB4 HGNC:17261 MOB family member 4, phocein Q9Y3A3 Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks. cytoplasm 8 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota MOBP HGNC:7189 myelin-associated oligodendrocyte basic protein Q13875 Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin (By similarity). Cytoplasm (GO:0005737) 9749786 cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eutheria Euteleostomi MOCOS HGNC:18234 molybdenum cofactor sulfurase Q96EN8 mitochondrion 15 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms MOCS1 HGNC:7190 molybdenum cofactor synthesis 1 Q9NZB8 Nucleus (GO:0005634) 9731530 mitochondrion 53 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms MOCS2 HGNC:7193 molybdenum cofactor synthesis 2 O96007 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms MOCS3 HGNC:15765 molybdenum cofactor synthesis 3 O95396 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 15073332 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms MOG HGNC:7197 myelin oligodendrocyte glycoprotein Q16653 Isoform 1: Cell membrane; Multi-pass membrane protein (Potential). Isoform 5: Cell membrane; Multi-pass membrane protein (Potential). Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 7790876,8915905 plasma membrane 29 2 plasma membrane plasma membrane Amniota Amniota NA MOGAT1 HGNC:18210 monoacylglycerol O-acyltransferase 1 Q96PD6 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 42 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota MOGAT2 HGNC:23248 monoacylglycerol O-acyltransferase 2 Q3SYC2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 14966132,12824082 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Cell.Organisms MOGAT3 HGNC:23249 monoacylglycerol O-acyltransferase 3 Q86VF5 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 12618427 endoplasmic reticulum membrane 35 2 endoplasmic reticulum endoplasmic reticulum Mammalia Mammalia Cell.Organisms MOGS HGNC:24862 mannosyl-oligosaccharide glucosidase Q13724 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 7635146,7635146,15598749 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Theria Eukaryota Eukaryota MOK HGNC:9833 MOK protein kinase Q9UQ07 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10421840 cytoplasm 80 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms MON1A HGNC:28207 MON1 secretory trafficking family member A Q86VX9 nucleus 15 2 nucleus nucleus Eukaryota Eukaryota Eukaryota MON1B HGNC:25020 MON1 secretory trafficking family member B Q7L1V2 Cytoplasm (GO:0005737) 12828340 nucleus 6 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MON2 HGNC:29177 MON2 homolog (S. cerevisiae) Q7Z3U7 nucleus 72 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MORC1 HGNC:7198 MORC family CW-type zinc finger 1 Q86VD1 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10369865,10369865 nucleus 61 0 cytoplasm. nucleus multiple Eutheria Bilateria Eukaryota MORC2 HGNC:23573 MORC family CW-type zinc finger 2 Q9Y6X9 Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 32 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms MORC3 HGNC:23572 MORC family CW-type zinc finger 3 Q14149 Nucleus (GO:0005634) 11927593 nucleus 21 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota MORC4 HGNC:23485 MORC family CW-type zinc finger 4 Q8TE76 Nucleus (Probable). Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus Mammalia Eukaryota Eukaryota MORF4L1 HGNC:16989 mortality factor 4 like 1 Q9UBU8 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12397079,15635413 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MORF4L2 HGNC:16849 mortality factor 4 like 2 Q15014 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9891081,11988016,11988016 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota MORN1 HGNC:25852 MORN repeat containing 1 Q5T089 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms MORN2 HGNC:30166 MORN repeat containing 2 Q502X0 cytoplasm 24 0 cytoplasm cytoplasm Amniota Cell.Organisms Cell.Organisms MORN3 HGNC:29807 MORN repeat containing 3 Q6PF18 cytoplasm 20 0 cytoplasm cytoplasm Mammalia Eukaryota NA MORN4 HGNC:24001 MORN repeat containing 4 Q8NDC4 Plasma membrane (GO:0005886) 17285308 cytoplasm 23 0 cytoplasm cytoplasm Amniota Bilateria Cell.Organisms MORN5 HGNC:17841 MORN repeat containing 5 Q5VZ52 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms MOS HGNC:7199 v-mos Moloney murine sarcoma viral oncogene homolog P00540 Cytoplasm (GO:0005737) 12022922 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms MOSPD1 HGNC:25235 motile sperm domain containing 1 Q9UJG1 Membrane; Multi-pass membrane protein (Potential). secreted 22 2 n/a n/a Euteleostomi Bilateria Holozoa MOSPD2 HGNC:28381 motile sperm domain containing 2 Q8NHP6 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 endoplasmic reticulum membrane 11 1 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota MOSPD3 HGNC:25078 motile sperm domain containing 3 O75425 Membrane; Multi-pass membrane protein (Potential). secreted 34 2 n/a n/a Euarchontoglires Eutheria Holozoa MOV10 HGNC:7200 Mov10, Moloney leukemia virus 10, homolog (mouse) Q9HCE1 Cytoplasm, P-body. Nucleus (GO:0005634);Cytoplasm (GO:0005737) 15561729/17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms MOV10L1 HGNC:7201 Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) Q9BXT6 cytoplasm 78 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms MOXD1 HGNC:21063 monooxygenase, DBH-like 1 Q6UVY6 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 15337741 endoplasmic reticulum membrane 81 1 endoplasmic reticulum endoplasmic reticulum Chordata Eukaryota Cell.Organisms MPC1 HGNC:21606 mitochondrial pyruvate carrier 1 Q9Y5U8 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 2 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota MPC1L HGNC:44205 mitochondrial pyruvate carrier 1-like P0DKB6 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 55 2 mitochondrion membrane mitochondrion membrane NA NA NA MPC2 HGNC:24515 mitochondrial pyruvate carrier 2 O95563 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 3 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota MPDU1 HGNC:7207 mannose-P-dolichol utilization defect 1 O75352 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11733556 endoplasmic reticulum membrane 46 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Eukaryota Eukaryota MPDZ HGNC:7208 multiple PDZ domain protein O75970 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11689568,11689568,17081983,11689568 secreted 24 0 cytoplasm. nucleus multiple Mammalia Bilateria Holozoa MPEG1 HGNC:29619 macrophage expressed 1 Q2M385 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 47 1 plasma membrane plasma membrane Mammalia Euteleostomi Metazoa MPG HGNC:7211 N-methylpurine-DNA glycosylase P29372 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12014652,14761960,12014652 nucleus 21 1 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms MPHOSPH10 HGNC:7213 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) O00566 Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8885239,9450966,15635413,11790298,9450966,9450966,15561729 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MPHOSPH6 HGNC:7214 M-phase phosphoprotein 6 Q99547 Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 8885239,8885239,15635413,8885239 nucleus 82 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta Holozoa MPHOSPH8 HGNC:29810 M-phase phosphoprotein 8 Q99549 Nucleus. Note=Detected on heterochromatin. Detected on nucleosomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8885239,17081983,8885239,17081983 nucleus 100 0 cytoplasm. nucleus multiple Mammalia Deuterostomia Cell.Organisms MPHOSPH9 HGNC:7215 M-phase phosphoprotein 9 Q99550 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein (Probable). Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8885239,8885239,8885239 cytoplasm 17 0 cytoplasm. golgi apparatus multiple Amniota Euteleostomi Bilateria MPI HGNC:7216 mannose phosphate isomerase P34949 Cytoplasm (Probable). Cytoplasm (GO:0005737) 12122025 cytoplasm 81 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms MPL HGNC:7217 myeloproliferative leukemia virus oncogene P40238 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8020956 plasma membrane 17 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi MPLKIP HGNC:16002 M-phase specific PLK1 interacting protein Q8TAP9 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase. Cytoplasm (GO:0005737) 17081983 nucleus 78 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Euteleostomi MPND HGNC:25934 MPN domain containing Q8N594 Nucleus (GO:0005634) 17081983 nucleus 27 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota MPO HGNC:7218 myeloperoxidase P05164 Lysosome. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Azurophil granule (GO:0042582) 17159117,9175709,15507754,2829220,2829220,2820530,2444596 secreted 41 0 cytoplasm. endoplasmic reticulum. lysosome. nucleus. secreted multiple Chordata Chordata Cell.Organisms MPP1 HGNC:7219 membrane protein, palmitoylated 1, 55kDa Q00013 Membrane; Lipid-anchor. Cell projection, stereocilium (By similarity). Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (). Colocalizes with NF2 in non- myelin-forming Schwann cells. Plasma membrane (GO:0005886) 1713685 cytoplasm 20 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA MPP2 HGNC:7220 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) Q14168 Plasma membrane (GO:0005886) 7590743 cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms MPP3 HGNC:7221 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) Q13368 Cytoplasm (GO:0005737) 13679854 cytoplasm 27 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms MPP4 HGNC:13680 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) Q96JB8 Cytoplasm. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ). cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms MPP5 HGNC:18669 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) Q8N3R9 Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon. Plasma membrane (GO:0005886) 10753959 cytoplasm 25 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MPP6 HGNC:18167 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) Q9NZW5 Membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886) 10753959 cytoplasm 21 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms MPP7 HGNC:26542 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) Q5T2T1 Membrane; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction. cytoplasm 33 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms MPPE1 HGNC:15988 metallophosphoesterase 1 Q53F39 Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site. endoplasmic reticulum membrane 10 2 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota Eukaryota MPPED1 HGNC:1306 metallophosphoesterase domain containing 1 O15442 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms MPPED2 HGNC:1180 metallophosphoesterase domain containing 2 Q15777 cytoplasm 20 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms MPRIP HGNC:30321 myosin phosphatase Rho interacting protein Q6WCQ1 Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14506264,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota MPST HGNC:7223 mercaptopyruvate sulfurtransferase P25325 Cytoplasm (By similarity). Mitochondrion (By similarity). Cell junction, synapse, synaptosome (By similarity). Mitochondrion (GO:0005739) 15033988,15598749 mitochondrion 50 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MPV17 HGNC:7224 MpV17 mitochondrial inner membrane protein P39210 Mitochondrion inner membrane; Multi-pass membrane protein. Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 12471025,16582907 mitochondrion membrane 100 4 mitochondrion. mitochondrion membrane. peroxisome multiple Mammalia Eukaryota Eukaryota MPV17L HGNC:26827 MPV17 mitochondrial membrane protein-like Q2QL34 Isoform 1: Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 16631601 peroxisome membrane 100 4 peroxisome. peroxisome membrane multiple Theria Eukaryota Eukaryota MPV17L2 HGNC:28177 MPV17 mitochondrial membrane protein-like 2 Q567V2 Membrane; Multi-pass membrane protein (Potential). peroxisome membrane 13 5 peroxisome membrane peroxisome membrane NA NA Eukaryota MPZ HGNC:7225 myelin protein zero P25189 Cell membrane; Single-pass type I membrane protein. Isoform L-MPZ: Myelin membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11673479 plasma membrane 92 1 plasma membrane plasma membrane Theria Euteleostomi Craniata MPZL1 HGNC:7226 myelin protein zero-like 1 O95297 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9792637,17081983,17081983 plasma membrane 23 1 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata MPZL2 HGNC:3496 myelin protein zero-like 2 O60487 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 9585423 plasma membrane 19 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Chordata MPZL3 HGNC:27279 myelin protein zero-like 3 Q6UWV2 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 17 2 plasma membrane plasma membrane Mammalia Euteleostomi Craniata MR1 HGNC:4975 major histocompatibility complex, class I-related Q95460 Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum. Isoform 4: Secreted. secreted 21 1 endoplasmic reticulum. plasma membrane. secreted multiple Euteleostomi Euteleostomi Craniata MRAP HGNC:1304 melanocortin 2 receptor accessory protein Q8TCY5 Cytoplasm, perinuclear region. Cytoplasm (By similarity). Cell membrane. Endoplasmic reticulum. Note=Concentrated at the perinuclear membrane region. Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm (By similarity). Localizes both to plasma membrane and endoplasmic reticulum. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12054497,12054497 secreted 15 1 cytoplasm. endoplasmic reticulum. plasma membrane multiple Amniota Euteleostomi Eutheria MRAP2 HGNC:21232 melanocortin 2 receptor accessory protein 2 Q96G30 Integral to membrane (GO:0016021) nucleus 19 1 nucleus nucleus Tetrapoda Euteleostomi Craniata MRAS HGNC:7227 muscle RAS oncogene homolog O14807 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9395237,9395237 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms MRC1 HGNC:7228 mannose receptor, C type 1 P22897 Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794);Integral to membrane (GO:0016021) 11841552,8940052,8940052/ secreted 27 1 endoplasmic reticulum. endosome membrane. golgi apparatus. plasma membrane multiple Deuterostomia Bilateria NA MRC2 HGNC:16875 mannose receptor, C type 2 Q9UBG0 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) endoplasmic reticulum membrane 36 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Bilateria Cell.Organisms MRE11A HGNC:7230 MRE11 meiotic recombination 11 homolog A (S. cerevisiae) P49959 Nucleus (By similarity). Note=Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/17081983/11238951,12679336 nucleus 33 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms MREG HGNC:25478 melanoregulin Q8N565 Apical cell membrane; Peripheral membrane protein (By similarity). Note=Localizes to the inner segment and basal outer segment of rods in the retina (By similarity). nucleus 63 0 nucleus nucleus Euteleostomi Euteleostomi Chordata MRFAP1 HGNC:24549 Morf4 family associated protein 1 Q9Y605 Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei. Nucleus (GO:0005634) 11500496 cytoplasm 49 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eutheria MRFAP1L1 HGNC:28796 Morf4 family associated protein 1-like 1 Q96HT8 cytoplasm 51 0 cytoplasm cytoplasm Human Catarrhini Eutheria MRGBP HGNC:15866 MRG/MORF4L binding protein Q9NV56 Nucleus. Nucleus (GO:0005634) 12963728 nucleus 100 0 nucleus nucleus Deuterostomia Opisthokonta Opisthokonta MRGPRD HGNC:29626 MAS-related GPR, member D Q8TDS7 Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Euteleostomi MRGPRE HGNC:30694 MAS-related GPR, member E Q86SM8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Theria Tetrapoda MRGPRF HGNC:24828 MAS-related GPR, member F Q96AM1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Euteleostomi MRGPRG HGNC:24829 MAS-related GPR, member G Q86SM5 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Tetrapoda MRGPRX1 HGNC:17962 MAS-related GPR, member X1 Q96LB2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Euarchontoglires Eumetazoa MRGPRX2 HGNC:17983 MAS-related GPR, member X2 Q96LB1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Eumetazoa MRGPRX3 HGNC:17980 MAS-related GPR, member X3 Q96LB0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Euarchontoglires Eumetazoa MRGPRX4 HGNC:17617 MAS-related GPR, member X4 Q96LA9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa MRI1 HGNC:28469 methylthioribose-1-phosphate isomerase 1 Q9BV20 Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells. cytoplasm 24 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MRM1 HGNC:26202 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) Q6IN84 Mitochondrion (Potential). mitochondrion 15 0 mitochondrion mitochondrion Chordata Cell.Organisms NA MRO HGNC:24121 maestro Q9BYG7 Nucleus, nucleolus (By similarity). nucleus 67 1 nucleus nucleus Mammalia Mammalia Eukaryota MROH1 HGNC:26958 maestro heat-like repeat family member 1 Q8NDA8 nucleus 12 0 nucleus nucleus Bilateria Eukaryota NA MROH2A HGNC:27936 maestro heat-like repeat family member 2A A6NES4 nucleus 17 0 nucleus nucleus Amniota Eukaryota Eukaryota MROH2B HGNC:26857 maestro heat-like repeat family member 2B Q7Z745 nucleus 23 0 nucleus nucleus Amniota Eukaryota Eukaryota MROH5 HGNC:42976 maestro heat-like repeat family member 5 Q6ZUA9 nucleus 13 0 nucleus nucleus NA NA Eukaryota MROH6 HGNC:27814 maestro heat-like repeat family member 6 A6NGR9 nucleus 39 0 nucleus nucleus Theria Theria Eukaryota MROH7 HGNC:24802 maestro heat-like repeat family member 7 Q68CQ1 Membrane; Multi-pass membrane protein (Potential). nucleus 83 4 nucleus nucleus Theria Theria Eukaryota MROH8 HGNC:16125 maestro heat-like repeat family member 8 Q9H579 Nucleolus (GO:0005730) 15635413 nucleus 40 0 nucleus nucleus Mammalia Mammalia Eukaryota MROH9 HGNC:26287 maestro heat-like repeat family member 9 Q5TGP6 secreted 48 1 secreted secreted Mammalia Mammalia Holozoa MRPL1 HGNC:14275 mitochondrial ribosomal protein L1 Q9BYD6 Mitochondrion. Mitochondrion (GO:0005739) 11279069,11543634,11551941 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms MRPL10 HGNC:14055 mitochondrial ribosomal protein L10 Q7Z7H8 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,3129699 mitochondrion 83 0 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms MRPL11 HGNC:14042 mitochondrial ribosomal protein L11 Q9Y3B7 Mitochondrion. Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 12706105/11279069 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL12 HGNC:10378 mitochondrial ribosomal protein L12 P52815 Mitochondrion. Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 8626705,15635413 mitochondrion 100 0 mitochondrion. nucleus multiple NA NA Cell.Organisms MRPL13 HGNC:14278 mitochondrial ribosomal protein L13 Q9BYD1 Mitochondrion. Mitochondrion (GO:0005739) 11279069 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL14 HGNC:14279 mitochondrial ribosomal protein L14 Q6P1L8 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634 mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Bilateria Cell.Organisms MRPL15 HGNC:14054 mitochondrial ribosomal protein L15 Q9P015 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,10593885,15598749 mitochondrion 89 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL16 HGNC:14476 mitochondrial ribosomal protein L16 Q9NX20 Mitochondrion. Mitochondrion (GO:0005739) 11543634 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL17 HGNC:14053 mitochondrial ribosomal protein L17 Q9NRX2 Mitochondrion (Potential). Mitochondrion (GO:0005739) 11543634 mitochondrion 87 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL18 HGNC:14477 mitochondrial ribosomal protein L18 Q9H0U6 Mitochondrion. Mitochondrion (GO:0005739) 11551941,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms MRPL19 HGNC:14052 mitochondrial ribosomal protein L19 P49406 Mitochondrion. Mitochondrion (GO:0005739) 11279069 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms MRPL2 HGNC:14056 mitochondrial ribosomal protein L2 Q5T653 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,10593885 mitochondrion 86 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL20 HGNC:14478 mitochondrial ribosomal protein L20 Q9BYC9 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11279069,11551941 mitochondrion 100 0 mitochondrion mitochondrion NA NA Cell.Organisms MRPL21 HGNC:14479 mitochondrial ribosomal protein L21 Q7Z2W9 Mitochondrion (By similarity). Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 11551941/11943462,11551941,12706105 mitochondrion 78 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota MRPL22 HGNC:14480 mitochondrial ribosomal protein L22 Q9NWU5 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,9857009,11551941,11943462,15598749 mitochondrion 88 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms MRPL23 HGNC:10322 mitochondrial ribosomal protein L23 Q16540 Mitochondrion. Ribosome (GO:0005840); Mitochondrion (GO:0005739) 8541832,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms MRPL24 HGNC:14037 mitochondrial ribosomal protein L24 Q96A35 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,15598749 mitochondrion 84 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL27 HGNC:14483 mitochondrial ribosomal protein L27 Q9P0M9 Mitochondrion. Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 12706105,11543634,11279069/11551941,11943462 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL28 HGNC:14484 mitochondrial ribosomal protein L28 Q13084 Mitochondrion. Mitochondrion (GO:0005739) 11551941 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota MRPL3 HGNC:10379 mitochondrial ribosomal protein L3 P09001 Mitochondrion. Nucleolus (GO:0005730); Ribosome (GO:0005840) 2891103,2891103 mitochondrion 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MRPL30 HGNC:14036 mitochondrial ribosomal protein L30 Q8TCC3 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,9857009 mitochondrion 83 0 mitochondrion mitochondrion Eutheria Bilateria Holozoa MRPL32 HGNC:14035 mitochondrial ribosomal protein L32 Q9BYC8 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11551941,11543634,11279069 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Opisthokonta MRPL33 HGNC:14487 mitochondrial ribosomal protein L33 O75394 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634 mitochondrion 100 0 mitochondrion mitochondrion NA NA Cell.Organisms MRPL34 HGNC:14488 mitochondrial ribosomal protein L34 Q9BQ48 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,11279069,10600119 mitochondrion 76 0 mitochondrion mitochondrion Amniota Opisthokonta Cell.Organisms MRPL35 HGNC:14489 mitochondrial ribosomal protein L35 Q9NZE8 Mitochondrion. Mitochondrion (GO:0005739) mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Eumetazoa MRPL36 HGNC:14490 mitochondrial ribosomal protein L36 Q9P0J6 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11279069 mitochondrion 100 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms MRPL37 HGNC:14034 mitochondrial ribosomal protein L37 Q9BZE1 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Bilateria Eumetazoa MRPL38 HGNC:14033 mitochondrial ribosomal protein L38 Q96DV4 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11543634 mitochondrion 81 0 mitochondrion mitochondrion Bilateria Bilateria Eukaryota MRPL39 HGNC:14027 mitochondrial ribosomal protein L39 Q9NYK5 Mitochondrion. Mitochondrion (GO:0005739) 11167009,15598749 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Bilateria Cell.Organisms MRPL4 HGNC:14276 mitochondrial ribosomal protein L4 Q9BYD3 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,11279069,15598749 mitochondrion 79 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPL40 HGNC:14491 mitochondrial ribosomal protein L40 Q9NQ50 Mitochondrion (By similarity). Ribosome (GO:0005840); Mitochondrion (GO:0005739) 9857009,15598749 mitochondrion 70 0 mitochondrion mitochondrion Theria Bilateria Bilateria MRPL41 HGNC:14492 mitochondrial ribosomal protein L41 Q8IXM3 Mitochondrion. Mitochondrion (GO:0005739) 11543634,9857009 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota MRPL42 HGNC:14493 mitochondrial ribosomal protein L42 Q9Y6G3 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11279123 mitochondrion 100 0 mitochondrion mitochondrion Amniota Bilateria Bilateria MRPL43 HGNC:14517 mitochondrial ribosomal protein L43 Q8N983 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,15598749 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota MRPL44 HGNC:16650 mitochondrial ribosomal protein L44 Q9H9J2 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11551941 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Bilateria Opisthokonta MRPL45 HGNC:16651 mitochondrial ribosomal protein L45 Q9BRJ2 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11551941,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota NA MRPL46 HGNC:1192 mitochondrial ribosomal protein L46 Q9H2W6 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11551941 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota MRPL47 HGNC:16652 mitochondrial ribosomal protein L47 Q9HD33 Mitochondrion. Mitochondrion (GO:0005739) 11551941,11943462,12706105,15598749 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota MRPL48 HGNC:16653 mitochondrial ribosomal protein L48 Q96GC5 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105 mitochondrion 82 0 mitochondrion mitochondrion Chordata Bilateria Metazoa MRPL49 HGNC:1176 mitochondrial ribosomal protein L49 Q13405 Mitochondrion. Mitochondrion (GO:0005739) none,15598749 mitochondrion 100 0 mitochondrion mitochondrion Theria Eukaryota Eukaryota MRPL50 HGNC:16654 mitochondrial ribosomal protein L50 Q8N5N7 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11551941 mitochondrion 72 0 mitochondrion mitochondrion Amniota Amniota Opisthokonta MRPL51 HGNC:14044 mitochondrial ribosomal protein L51 Q4U2R6 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11551941,11543634,11402041 mitochondrion 78 0 mitochondrion mitochondrion Bilateria Bilateria Bilateria MRPL52 HGNC:16655 mitochondrial ribosomal protein L52 Q86TS9 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11943462,11551941 mitochondrion 83 0 mitochondrion mitochondrion Theria Bilateria Holozoa MRPL53 HGNC:16684 mitochondrial ribosomal protein L53 Q96EL3 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11551941 mitochondrion 90 0 mitochondrion mitochondrion Eutheria Bilateria Metazoa MRPL54 HGNC:16685 mitochondrial ribosomal protein L54 Q6P161 Mitochondrion (By similarity). Mitochondrion (GO:0005739) mitochondrion 68 0 mitochondrion mitochondrion Theria Bilateria Holozoa MRPL55 HGNC:16686 mitochondrial ribosomal protein L55 Q7Z7F7 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11943462 mitochondrion 63 0 mitochondrion mitochondrion Theria Bilateria Eumetazoa MRPL57 HGNC:14514 mitochondrial ribosomal protein L57 Q9BQC6 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105 mitochondrion 76 0 mitochondrion mitochondrion Mammalia Bilateria Eumetazoa MRPL9 HGNC:14277 mitochondrial ribosomal protein L9 Q9BYD2 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11279069,11551941 mitochondrion 100 0 mitochondrion mitochondrion Theria Bilateria Cell.Organisms MRPS10 HGNC:14502 mitochondrial ribosomal protein S10 P82664 Mitochondrion. Mitochondrion (GO:0005739) 11279123,12706105,10938081 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Cell.Organisms MRPS11 HGNC:14050 mitochondrial ribosomal protein S11 P82912 Mitochondrion. Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 12706105,11543634,11402041/11279123 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPS12 HGNC:10380 mitochondrial ribosomal protein S12 O15235 Mitochondrion. Mitochondrion (GO:0005739) 10542210 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPS14 HGNC:14049 mitochondrial ribosomal protein S14 O60783 Mitochondrion. Mitochondrion (GO:0005739) 11543634,11279123,10938081 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPS15 HGNC:14504 mitochondrial ribosomal protein S15 P82914 Mitochondrion. Mitochondrion (GO:0005739); Ribosome (GO:0005840) 11279123,11279123 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPS16 HGNC:14048 mitochondrial ribosomal protein S16 Q9Y3D3 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11402041,11279123 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRPS17 HGNC:14047 mitochondrial ribosomal protein S17 Q9Y2R5 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12706105,11543634,11402041,11279123,17081983 mitochondrion 100 0 mitochondrion. nucleus multiple NA NA Cell.Organisms MRPS18A HGNC:14515 mitochondrial ribosomal protein S18A Q9NVS2 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11402041,11279123 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Bilateria Cell.Organisms MRPS18B HGNC:14516 mitochondrial ribosomal protein S18B Q9Y676 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11402041,11279123 mitochondrion 100 0 mitochondrion mitochondrion Theria Bilateria NA MRPS18C HGNC:16633 mitochondrial ribosomal protein S18C Q9Y3D5 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11279123 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms MRPS2 HGNC:14495 mitochondrial ribosomal protein S2 Q9Y399 Mitochondrion. Mitochondrion (GO:0005739) 11543634,11402041,11279123,15598749 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms MRPS21 HGNC:14046 mitochondrial ribosomal protein S21 P82921 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,11402041,11279123 mitochondrion 100 0 mitochondrion mitochondrion NA NA Eumetazoa MRPS22 HGNC:14508 mitochondrial ribosomal protein S22 P82650 Mitochondrion. Mitochondrion (GO:0005739) 15081106,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Holozoa MRPS23 HGNC:14509 mitochondrial ribosomal protein S23 Q9Y3D9 Mitochondrion. Mitochondrion (GO:0005739) 11279123,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Metazoa MRPS24 HGNC:14510 mitochondrial ribosomal protein S24 Q96EL2 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12706105,11543634,8127713 mitochondrion 82 0 mitochondrion mitochondrion Bilateria Bilateria Eumetazoa MRPS25 HGNC:14511 mitochondrial ribosomal protein S25 P82663 Mitochondrion. Mitochondrion (GO:0005739) 12706105,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Metazoa MRPS26 HGNC:14045 mitochondrial ribosomal protein S26 Q9BYN8 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11543634,15598749 mitochondrion 100 0 mitochondrion mitochondrion Theria Deuterostomia Deuterostomia MRPS27 HGNC:14512 mitochondrial ribosomal protein S27 Q92552 Mitochondrion. Mitochondrion (GO:0005739) none,15598749 mitochondrion 100 0 mitochondrion mitochondrion Amniota Deuterostomia Eukaryota MRPS28 HGNC:14513 mitochondrial ribosomal protein S28 Q9Y2Q9 Mitochondrion. Ribosome (GO:0005840); Mitochondrion (GO:0005739) 11279123,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Eukaryota MRPS30 HGNC:8769 mitochondrial ribosomal protein S30 Q9NP92 Mitochondrion. Mitochondrion (GO:0005739) 11543634 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Bilateria Metazoa MRPS31 HGNC:16632 mitochondrial ribosomal protein S31 Q92665 Mitochondrion. Mitochondrion (GO:0005739) 8567980,15598749 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Bilateria Metazoa MRPS33 HGNC:16634 mitochondrial ribosomal protein S33 Q9Y291 Mitochondrion. Mitochondrion (GO:0005739) mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Metazoa MRPS34 HGNC:16618 mitochondrial ribosomal protein S34 P82930 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11279123,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Holozoa MRPS35 HGNC:16635 mitochondrial ribosomal protein S35 P82673 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11279123 mitochondrion 80 0 mitochondrion mitochondrion Bilateria Bilateria Holozoa MRPS36 HGNC:16631 mitochondrial ribosomal protein S36 P82909 Mitochondrion. Mitochondrion (GO:0005739) 11279123 mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Deuterostomia NA MRPS5 HGNC:14498 mitochondrial ribosomal protein S5 P82675 Mitochondrion. Mitochondrion (GO:0005739) 11279123,15598749 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms MRPS6 HGNC:14051 mitochondrial ribosomal protein S6 P82932 Mitochondrion. Mitochondrion (GO:0005739) 11279123,15598749 mitochondrion 100 0 mitochondrion mitochondrion NA NA Cell.Organisms MRPS7 HGNC:14499 mitochondrial ribosomal protein S7 Q9Y2R9 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 10581179 mitochondrion 82 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms MRPS9 HGNC:14501 mitochondrial ribosomal protein S9 P82933 Mitochondrion. Mitochondrion (GO:0005739) 12706105,11344316,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRRF HGNC:7234 mitochondrial ribosome recycling factor Q96E11 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 9838146 mitochondrion 8 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MRS2 HGNC:13785 MRS2 magnesium transporter Q9HD23 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 11401429 mitochondrion membrane 10 2 mitochondrion mitochondrion Chordata Eukaryota Eukaryota MRTO4 HGNC:18477 mRNA turnover 4 homolog (S. cerevisiae) Q9UKD2 Nucleus, nucleolus. Nucleolus (GO:0005730) 11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms MRVI1 HGNC:7237 murine retrovirus integration site 1 homolog Q9Y6F6 Cytoplasm, perinuclear region. Sarcoplasmic reticulum (By similarity). Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 2271613,10724174 secreted 6 1 cytoplasm. endoplasmic reticulum. plasma membrane multiple Amniota Euteleostomi Bilateria MS4A1 HGNC:7315 membrane-spanning 4-domains, subfamily A, member 1 P11836 Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Plasma membrane (GO:0005886) 7684739 golgi apparatus membrane 28 4 plasma membrane plasma membrane Mammalia Mammalia Bilateria MS4A10 HGNC:13368 membrane-spanning 4-domains, subfamily A, member 10 Q96PG2 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) 11245982 plasma membrane 23 4 plasma membrane plasma membrane Euarchontoglires Eutheria Amniota MS4A12 HGNC:13370 membrane-spanning 4-domains, subfamily A, member 12 Q9NXJ0 Membrane; Multi-pass membrane protein. plasma membrane 18 4 plasma membrane plasma membrane Euarchontoglires Amniota Euteleostomi MS4A13 HGNC:16674 membrane-spanning 4-domains, subfamily A, member 13 Q5J8X5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 41 4 golgi apparatus membrane golgi apparatus membrane Euarchontoglires Eutheria Eutheria MS4A14 HGNC:30706 membrane-spanning 4-domains, subfamily A, member 14 Q96JA4 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11382755 secreted 6 4 plasma membrane plasma membrane Eutheria Eutheria Eukaryota MS4A15 HGNC:28573 membrane-spanning 4-domains, subfamily A, member 15 Q8N5U1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 15 4 golgi apparatus membrane golgi apparatus membrane Mammalia Mammalia Bilateria MS4A18 HGNC:37636 membrane-spanning 4-domains, subfamily A, member 18 Q3C1V0 Membrane; Multi-pass membrane protein (Potential). plasma membrane 38 4 plasma membrane plasma membrane NA NA Bilateria MS4A2 HGNC:7316 membrane-spanning 4-domains, subfamily A, member 2 Q01362 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12217393,11134951 golgi apparatus membrane 28 4 plasma membrane plasma membrane Theria Chordata Amniota MS4A3 HGNC:7317 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) Q96HJ5 Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Located in the perinuclear area. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11781350,11781350 golgi apparatus membrane 40 4 endoplasmic reticulum. nucleus multiple Theria Theria Amniota MS4A4A HGNC:13371 membrane-spanning 4-domains, subfamily A, member 4A Q96JQ5 Membrane; Multi-pass membrane protein. golgi apparatus membrane 25 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Euteleostomi MS4A4E HGNC:14284 membrane-spanning 4-domains, subfamily A, member 4E Q96PG1 Membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 24 2 mitochondrion membrane mitochondrion membrane Human Catarrhini Mammalia MS4A5 HGNC:13374 membrane-spanning 4-domains, subfamily A, member 5 Q9H3V2 Membrane; Multi-pass membrane protein. golgi apparatus membrane 36 4 golgi apparatus membrane golgi apparatus membrane Theria Theria Bilateria MS4A6A HGNC:13375 membrane-spanning 4-domains, subfamily A, member 6A Q9H2W1 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11401424 golgi apparatus membrane 28 4 golgi apparatus membrane golgi apparatus membrane Euarchontoglires Eutheria Euteleostomi MS4A6E HGNC:14285 membrane-spanning 4-domains, subfamily A, member 6E Q96DS6 Membrane; Multi-pass membrane protein. plasma membrane 9 2 plasma membrane plasma membrane Homininae Homininae Eutheria MS4A7 HGNC:13378 membrane-spanning 4-domains, subfamily A, member 7 Q9GZW8 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11685457 vacuole membrane 16 4 vacuole membrane vacuole membrane Eutheria Eutheria Mammalia MS4A8 HGNC:13380 membrane-spanning 4-domains, subfamily A, member 8 Q9BY19 Membrane; Multi-pass membrane protein. golgi apparatus membrane 21 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Bilateria MSANTD1 HGNC:33741 Myb/SANT-like DNA-binding domain containing 1 Q6ZTZ1 nucleus 59 0 nucleus nucleus Theria Bilateria Metazoa MSANTD2 HGNC:26266 Myb/SANT-like DNA-binding domain containing 2 Q6P1R3 nucleus 31 0 nucleus nucleus Amniota Euteleostomi Metazoa MSANTD3 HGNC:23370 Myb/SANT-like DNA-binding domain containing 3 Q96H12 Nucleus (GO:0005634) 17081983 nucleus 84 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria MSANTD4 HGNC:29383 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils Q8NCY6 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Bilateria MSC HGNC:7321 musculin O60682 Nucleus. Nucleus (GO:0005634) 9584154 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eumetazoa MSGN1 HGNC:14907 mesogenin 1 A6NI15 Nucleus (Potential). nucleus 53 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa MSH2 HGNC:7325 mutS homolog 2 P43246 Nucleus (Potential). Nucleus (GO:0005634) 7604264,12610360,15561729 nucleus 30 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms MSH3 HGNC:7326 mutS homolog 3 P20585 Nucleus (GO:0005634) 11920679 nucleus 24 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms MSH4 HGNC:7327 mutS homolog 4 O15457 Nucleus (GO:0005634) 10809667 nucleus 22 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms MSH5 HGNC:7328 mutS homolog 5 O43196 Nucleus (GO:0005634); Extracellular (GO:0005576) 9740671,10029069,9916805,14718574 nucleus 16 0 nucleus. secreted multiple Eukaryota Eukaryota NA MSH6 HGNC:7329 mutS homolog 6 P52701 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10954713,17081983,10954713,17081983 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MSI1 HGNC:7330 musashi RNA-binding protein 1 O43347 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 11588182 cytoplasm 66 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms MSI2 HGNC:18585 musashi RNA-binding protein 2 Q96DH6 Cytoplasm. Note=Associated with polysomes (By similarity). Cytoplasm (GO:0005737) 11588182 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms MSL1 HGNC:27905 male-specific lethal 1 homolog (Drosophila) Q68DK7 Nucleus. nucleus 100 0 nucleus nucleus Chordata Chordata Metazoa MSL2 HGNC:25544 male-specific lethal 2 homolog (Drosophila) Q9HCI7 nucleus 22 0 nucleus nucleus Chordata Bilateria Metazoa MSL3 HGNC:7370 male-specific lethal 3 homolog (Drosophila) Q8N5Y2 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10395802,17081983,17081983 nucleus 17 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Eukaryota MSLN HGNC:7371 mesothelin Q13421 Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Megakaryocyte-potentiating factor: Secreted. Isoform 3: Secreted. secreted 80 1 golgi apparatus. secreted multiple Theria Amniota Euteleostomi MSLNL HGNC:14170 mesothelin-like Q96KJ4 Membrane; Single-pass type I membrane protein (Potential). secreted 88 1 secreted secreted Eutheria Euteleostomi Eukaryota MSMB HGNC:7372 microseminoprotein, beta- P08118 Secreted. Note=Sperm surface. Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 2475560,2758596,2475560,2475560 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Tetrapoda Tetrapoda NA MSMO1 HGNC:10545 methylsterol monooxygenase 1 Q15800 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 8663358,8663358 endoplasmic reticulum membrane 23 5 endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane multiple Amniota Eukaryota Cell.Organisms MSMP HGNC:29663 microseminoprotein, prostate associated Q1L6U9 Secreted. Cytoplasm (GO:0005737) 17338636 secreted 100 0 cytoplasm. secreted multiple Catarrhini Chordata Olfactores MSN HGNC:7373 moesin P26038 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Apical cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Phosphorylated form is enriched in microvilli- like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non- phosphorylated forms seen after thrombin treatment. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Mitochondrion (GO:0005739) 8259662,12787041,9918767,8188263,9856983,15149851,15561729,15598749 secreted 15 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota MSR1 HGNC:7376 macrophage scavenger receptor 1 P21757 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12819208,1519666,12819208,12819208 secreted 54 1 endoplasmic reticulum. endosome. golgi apparatus. plasma membrane multiple Mammalia Mammalia Cell.Organisms MSRA HGNC:7377 methionine sulfoxide reductase A Q9UJ68 Isoform 1: Mitochondrion. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Nucleus. Isoform 5: Cytoplasm. Membrane; Lipid- anchor. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 12039877,12693988,12693988 mitochondrion 36 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MSRB1 HGNC:14133 methionine sulfoxide reductase B1 Q9NZV6 Cytoplasm (By similarity). Nucleus (By similarity). mitochondrion 25 0 mitochondrion mitochondrion Amniota Euteleostomi Cell.Organisms MSRB2 HGNC:17061 methionine sulfoxide reductase B2 Q9Y3D2 Mitochondrion. Nucleus (GO:0005634) 10375640 mitochondrion 100 0 mitochondrion. nucleus multiple Catarrhini Eukaryota Cell.Organisms MSRB3 HGNC:27375 methionine sulfoxide reductase B3 Q8IXL7 Isoform 1: Endoplasmic reticulum. Isoform 2: Mitochondrion. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 14699060,15249228,14699060,15249228 endoplasmic reticulum 84 0 endoplasmic reticulum. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms MSS51 HGNC:21000 MSS51 mitochondrial translational activator Q4VC12 endoplasmic reticulum membrane 26 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Eukaryota MST1 HGNC:7380 macrophage stimulating 1 (hepatocyte growth factor-like) P26927 Secreted. Extracellular (GO:0005576) 10068459 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms MST1R HGNC:7381 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Q04912 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8062829 plasma membrane 26 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms MSTN HGNC:4223 myostatin O14793 Secreted. Extracellular (GO:0005576) 10362012 secreted 100 0 secreted secreted Euteleostomi Bilateria Metazoa MSTO1 HGNC:29678 misato 1, mitochondrial distribution and morphology regulator Q9BUK6 Mitochondrion outer membrane. mitochondrion 11 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota MSX1 HGNC:7391 msh homeobox 1 P28360 Nucleus. Nucleus (GO:0005634) 8696335 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta MSX2 HGNC:7392 msh homeobox 2 P35548 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9373945,9373945 nucleus 100 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota MT-ATP6 HGNC:7414 mitochondrially encoded ATP synthase 6 P00846 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 11925565 mitochondrion membrane 100 6 mitochondrion. mitochondrion membrane multiple Amniota Cell.Organisms Cell.Organisms MT-ATP8 HGNC:7415 mitochondrially encoded ATP synthase 8 P03928 Mitochondrion membrane; Single-pass membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane NA NA Mammalia MT-CO1 HGNC:7419 mitochondrially encoded cytochrome c oxidase I P00395 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 12 mitochondrion membrane mitochondrion membrane Cell.Organisms Cell.Organisms Cell.Organisms MT-CO2 HGNC:7421 mitochondrially encoded cytochrome c oxidase II P00403 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 6251383 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms MT-CO3 HGNC:7422 mitochondrially encoded cytochrome c oxidase III P00414 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 8240356 mitochondrion membrane 85 7 mitochondrion mitochondrion Amniota Cell.Organisms Cell.Organisms MT-CYB HGNC:7427 mitochondrially encoded cytochrome b P00156 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion 52 9 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MT-ND1 HGNC:7455 mitochondrially encoded NADH dehydrogenase 1 P03886 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 9878551 mitochondrion membrane 74 7 mitochondrion mitochondrion Amniota Cell.Organisms Cell.Organisms MT-ND2 HGNC:7456 mitochondrially encoded NADH dehydrogenase 2 P03891 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9878551,15069201 mitochondrion membrane 100 11 mitochondrion. mitochondrion membrane multiple Amniota Cell.Organisms Cell.Organisms MT-ND3 HGNC:7458 mitochondrially encoded NADH dehydrogenase 3 P03897 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 9878551 mitochondrion membrane 67 3 mitochondrion mitochondrion Amniota Cell.Organisms Eukaryota MT-ND4 HGNC:7459 mitochondrially encoded NADH dehydrogenase 4 P03905 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 3921850 mitochondrion membrane 68 13 mitochondrion mitochondrion Amniota Cell.Organisms Cell.Organisms MT-ND4L HGNC:7460 mitochondrially encoded NADH dehydrogenase 4L P03901 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 3921850 mitochondrion membrane 67 3 mitochondrion mitochondrion Human Human Eukaryota MT-ND5 HGNC:7461 mitochondrially encoded NADH dehydrogenase 5 P03915 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 9878551 mitochondrion membrane 62 16 mitochondrion mitochondrion Amniota Cell.Organisms Cell.Organisms MT-ND6 HGNC:7462 mitochondrially encoded NADH dehydrogenase 6 P03923 Mitochondrion membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) 15922297 golgi apparatus membrane 49 5 mitochondrion mitochondrion Amniota Bilateria Cell.Organisms MT1A HGNC:7393 metallothionein 1A P04731 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12361735,10574972,10099782,12361735,11284736,10884303,10574972,10099782,9614853 secreted 100 0 cytoplasm. mitochondrion. nucleus multiple Human Human NA MT1B HGNC:7394 metallothionein 1B P07438 secreted 100 0 secreted secreted Homininae Homininae Primates MT1E HGNC:7397 metallothionein 1E P04732 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7932184,7932184,11053642 secreted 100 0 cytoplasm. nucleus multiple Mammalia Mammalia Eutheria MT1F HGNC:7398 metallothionein 1F P04733 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8619255,8619255 secreted 100 0 cytoplasm. nucleus multiple Human Human Eutheria MT1G HGNC:7399 metallothionein 1G P13640 secreted 100 0 secreted secreted Homininae Homininae Primates MT1H HGNC:7400 metallothionein 1H P80294 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8619255,8619255 secreted 100 0 cytoplasm. nucleus multiple Homininae Homininae Primates MT1HL1 HGNC:31864 metallothionein 1H-like 1 P0DM35 secreted 100 0 secreted secreted NA NA NA MT1L HGNC:7404 metallothionein 1L (gene/pseudogene) Q93083 secreted 100 0 secreted secreted NA NA NA MT1M HGNC:14296 metallothionein 1M Q8N339 secreted 100 0 secreted secreted Human Human Eutheria MT1X HGNC:7405 metallothionein 1X P80297 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 8619255,10754528,8619255,10754528,14718574 secreted 100 0 cytoplasm. nucleus. secreted multiple Human Amniota Eutheria MT2A HGNC:7406 metallothionein 2A P02795 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12646258,10766190,12646258,10567918 secreted 100 0 cytoplasm. nucleus multiple Mammalia Mammalia Eutheria MT3 HGNC:7408 metallothionein 3 P25713 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576); Mitochondrion (GO:0005739) 12067712,12067712,12058024,11226237 secreted 100 0 cytoplasm. mitochondrion. nucleus. secreted multiple Euarchontoglires Eutheria Amniota MT4 HGNC:18705 metallothionein 4 P47944 Cytoplasm (GO:0005737) 8003488 secreted 100 0 cytoplasm cytoplasm Amniota Amniota Mammalia MTA1 HGNC:7410 metastasis associated 1 Q13330 Isoform Short: Cytoplasm. Isoform Long: Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12920132,10967548,16511565,15978591,17081983,12167865 nucleus 96 0 cytoplasm. nucleus multiple Bilateria Bilateria NA MTA2 HGNC:7411 metastasis associated 1 family, member 2 O94776 Nucleus (By similarity). Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 11102443,11102443 nucleus 98 0 golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota MTA3 HGNC:23784 metastasis associated 1 family, member 3 Q9BTC8 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Holozoa MTAP HGNC:7413 methylthioadenosine phosphorylase Q13126 Cytoplasm. Nucleus (By similarity). Cytoplasm (GO:0005737) cytoplasm 15 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms MTBP HGNC:7417 MDM2 binding protein Q96DY7 nucleus 92 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa MTCH1 HGNC:17586 mitochondrial carrier 1 Q9NZJ7 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) 12377771 mitochondrion membrane 15 3 mitochondrion mitochondrion Amniota Amniota Eukaryota MTCH2 HGNC:17587 mitochondrial carrier 2 Q9Y6C9 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) 15598749 mitochondrion membrane 23 2 mitochondrion mitochondrion Bilateria Bilateria Eukaryota MTCL1 HGNC:29121 microtubule crosslinking factor 1 Q9Y4B5 secreted 28 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms MTCP1 HGNC:7423 mature T-cell proliferation 1 P56278 Mitochondrion (GO:0005739);Cytoplasm (GO:0005737) 7784073/7970717 nucleus 45 0 cytoplasm. mitochondrion multiple Amniota Amniota NA MTDH HGNC:29608 metadherin Q86UE4 Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein (By similarity). Cell junction, tight junction (By similarity). Nucleus, nucleolus (By similarity). Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Nucleolus (GO:0005730); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14980505,14980505,17081983,14980505,15383321,17081983 nucleus 28 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus. plasma membrane multiple Amniota Euteleostomi Craniata MTERF HGNC:21463 mitochondrial transcription termination factor Q99551 Mitochondrion. Mitochondrion (GO:0005739) 7681833,9118945 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Deuterostomia Bilateria MTERFD1 HGNC:24258 MTERF domain containing 1 Q96E29 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Chordata Eukaryota Eukaryota MTERFD2 HGNC:28785 MTERF domain containing 2 Q7Z6M4 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Mammalia Bilateria Eumetazoa MTERFD3 HGNC:30779 MTERF domain containing 3 Q49AM1 Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid (By similarity). Mitochondrion (GO:0005739) 16226716 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Eukaryota MTF1 HGNC:7428 metal-regulatory transcription factor 1 Q14872 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11306562,11306562 nucleus 37 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota MTF2 HGNC:29535 metal response element binding transcription factor 2 Q9Y483 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 97 0 nucleus nucleus Deuterostomia Bilateria Eukaryota MTFMT HGNC:29666 mitochondrial methionyl-tRNA formyltransferase Q96DP5 Mitochondrion (By similarity). Mitochondrion (GO:0005739) mitochondrion 84 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTFP1 HGNC:26945 mitochondrial fission process 1 Q9UDX5 Mitochondrion inner membrane; Multi-pass membrane protein (Probable). mitochondrion membrane 32 3 mitochondrion membrane mitochondrion membrane NA NA Opisthokonta MTFR1 HGNC:29510 mitochondrial fission regulator 1 Q15390 Mitochondrion (By similarity). Note=May be associated with the inner and the outer mitochondrial membrane (By similarity). Mitochondrion (GO:0005739) 15389597 mitochondrion 57 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Holozoa MTFR1L HGNC:28836 mitochondrial fission regulator 1-like Q9H019 mitochondrion 16 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Craniata MTFR2 HGNC:21115 mitochondrial fission regulator 2 Q6P444 Mitochondrion (By similarity). Note=Associated with membranes (By similarity). mitochondrion 59 0 mitochondrion mitochondrion Chordata Chordata Holozoa MTG1 HGNC:32159 mitochondrial ribosome-associated GTPase 1 Q9BT17 Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. nucleus 20 0 mitochondrion mitochondrion NA NA Cell.Organisms MTG2 HGNC:16239 mitochondrial ribosome-associated GTPase 2 Q9H4K7 Mitochondrion. Mitochondrion (GO:0005739) 16582907 nucleus 28 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTHFD1 HGNC:7432 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase P11586 Cytoplasm. Cytoplasm (GO:0005737); Cytosol (GO:0005829); Mitochondrion (GO:0005739) 3074630,16263121,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms MTHFD1L HGNC:21055 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Q6UB35 Mitochondrion. Mitochondrion (GO:0005739) 12937168,15013446,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTHFD2 HGNC:7434 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase P13995 Mitochondrion. Mitochondrion (GO:0005739) 9454603,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTHFD2L HGNC:31865 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Q9H903 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity). Integral to membrane (GO:0016021) mitochondrion 66 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTHFR HGNC:7436 methylenetetrahydrofolate reductase (NAD(P)H) P42898 Extracellular (GO:0005576) 7647779 cytoplasm 48 0 secreted secreted Eukaryota Cell.Organisms Cell.Organisms MTHFS HGNC:7437 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) P49914 Cytoplasm. Mitochondrion (GO:0005739) 12764149 cytoplasm 100 0 cytoplasm. mitochondrion multiple Opisthokonta Cell.Organisms Cell.Organisms MTHFSD HGNC:25778 methenyltetrahydrofolate synthetase domain containing Q2M296 nucleus 42 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms MTIF2 HGNC:7441 mitochondrial translational initiation factor 2 P46199 Mitochondrion. Mitochondrion (GO:0005739) 12932832 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTIF3 HGNC:29788 mitochondrial translational initiation factor 3 Q9H2K0 Mitochondrion (Probable). Mitochondrion (GO:0005739) 12095986 mitochondrion 13 0 mitochondrion mitochondrion Amniota Deuterostomia Deuterostomia MTL5 HGNC:7446 metallothionein-like 5, testis-specific (tesmin) Q9Y4I5 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12606435,11803038,12606435,11803038 nucleus 34 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota MTM1 HGNC:7448 myotubularin 1 Q13496 Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Late endosome. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation. Cytoplasm (GO:0005737) 10900271 nucleus 26 0 cytoplasm. endosome multiple Bilateria Eukaryota NA MTMR1 HGNC:7449 myotubularin related protein 1 Q13613 Cell membrane; Peripheral membrane protein; Cytoplasmic side. nucleus 24 0 nucleus nucleus Bilateria Eukaryota NA MTMR10 HGNC:25999 myotubularin related protein 10 Q9NXD2 cytoplasm 25 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota MTMR11 HGNC:24307 myotubularin related protein 11 A4FU01 nucleus 18 0 nucleus nucleus Theria Euteleostomi NA MTMR12 HGNC:18191 myotubularin related protein 12 Q9C0I1 Cytoplasm. Note=Localizes to punctate vesicles when associated with MTM1. Cytoplasm (GO:0005737) 11504939 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eukaryota MTMR14 HGNC:26190 myotubularin related protein 14 Q8NCE2 Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 17008356,17008356,17008356,17008356 cytoplasm 100 0 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Eukaryota Eukaryota MTMR2 HGNC:7450 myotubularin related protein 2 Q13614 Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Partly associated with membranes. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12837694,17081983,12837694 cytoplasm 27 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota MTMR3 HGNC:7451 myotubularin related protein 3 Q13615 Cytoplasm. Membrane; Peripheral membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11302699,10733931,11846405 nucleus 26 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota MTMR4 HGNC:7452 myotubularin related protein 4 Q9NYA4 Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11302699,11302699 nucleus 40 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota MTMR6 HGNC:7453 myotubularin related protein 6 Q9Y217 Nucleus envelope. Cytoplasm (GO:0005737) none,17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota MTMR7 HGNC:7454 myotubularin related protein 7 Q9Y216 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota MTMR8 HGNC:16825 myotubularin related protein 8 Q96EF0 Nucleus envelope. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms MTMR9 HGNC:14596 myotubularin related protein 9 Q96QG7 Cytoplasm. Cytoplasm (GO:0005737) 12890864 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota MTNR1A HGNC:7463 melatonin receptor 1A P48039 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11606436,17215244 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa MTNR1B HGNC:7464 melatonin receptor 1B P49286 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11606436,17215244 plasma membrane 100 7 plasma membrane plasma membrane Deuterostomia Deuterostomia Metazoa MTO1 HGNC:19261 mitochondrial tRNA translation optimization 1 Q9Y2Z2 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 12011058 mitochondrion 84 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTOR HGNC:3942 mechanistic target of rapamycin (serine/threonine kinase) P42345 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm (By similarity). Nucleus, PML body (By similarity). Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 9434772,16221682,11114166,9434772,11114166,12000755,16221682,11930000,15561729 nucleus 25 0 cytoplasm. lysosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota MTPAP HGNC:25532 mitochondrial poly(A) polymerase Q9NVV4 Cytoplasm. Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15547249,15561729 nucleus 17 1 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Bilateria Eukaryota MTPN HGNC:15667 myotrophin P58546 Cytoplasm (Probable). Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11971907,11971907 nucleus 24 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms MTR HGNC:7468 5-methyltetrahydrofolate-homocysteine methyltransferase Q99707 Cytoplasm. Cytoplasm (GO:0005737) 1516297,2070814 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms MTRF1 HGNC:7469 mitochondrial translational release factor 1 O75570 Mitochondrion. Mitochondrion (GO:0005739) 9838146 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Euteleostomi Cell.Organisms MTRF1L HGNC:21051 mitochondrial translational release factor 1-like Q9UGC7 Mitochondrion. Mitochondrion (GO:0005739) mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms MTRNR2L1 HGNC:37155 MT-RNR2-like 1 P0CJ68 Cytoplasm (By similarity). Secreted (By similarity). secreted 80 0 secreted secreted NA NA Homo MTRNR2L10 HGNC:37167 MT-RNR2-like 10 P0CJ77 Cytoplasm (By similarity). Secreted (By similarity). secreted 68 0 secreted secreted NA NA NA MTRNR2L2 HGNC:37156 MT-RNR2-like 2 P0CJ69 Cytoplasm (By similarity). Secreted (By similarity). secreted 69 0 secreted secreted NA NA NA MTRNR2L3 HGNC:37157 MT-RNR2-like 3 P0CJ70 Cytoplasm (By similarity). Secreted (By similarity). secreted 72 0 secreted secreted NA NA NA MTRNR2L4 HGNC:37161 MT-RNR2-like 4 P0CJ71 Cytoplasm (By similarity). Secreted (By similarity). secreted 86 0 secreted secreted NA NA NA MTRNR2L5 HGNC:37162 MT-RNR2-like 5 P0CJ72 Cytoplasm (By similarity). Secreted (By similarity). secreted 84 0 secreted secreted NA NA NA MTRNR2L6 HGNC:37163 MT-RNR2-like 6 P0CJ73 Cytoplasm (By similarity). Secreted (By similarity). secreted 78 0 secreted secreted NA NA NA MTRNR2L7 HGNC:37164 MT-RNR2-like 7 P0CJ74 Cytoplasm (By similarity). Secreted (By similarity). secreted 71 0 secreted secreted NA NA NA MTRNR2L8 HGNC:37165 MT-RNR2-like 8 P0CJ75 Cytoplasm (By similarity). Secreted (By similarity). secreted 81 0 secreted secreted NA NA Homo MTRR HGNC:7473 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Q9UBK8 Isoform B: Cytoplasm. Isoform C: Cytoplasm. Isoform A: Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Human Eukaryota Cell.Organisms MTSS1 HGNC:20443 metastasis suppressor 1 O43312 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 12570871,12570871 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa MTSS1L HGNC:25094 metastasis suppressor 1-like Q765P7 cytoplasm 52 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa MTTP HGNC:7467 microsomal triglyceride transfer protein P55157 Endoplasmic reticulum. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 1439810,12020640 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Bilateria Bilateria MTURN HGNC:25457 maturin, neural progenitor differentiation regulator homolog (Xenopus) Q8N3F0 secreted 67 0 secreted secreted Tetrapoda Euteleostomi Bilateria MTUS1 HGNC:29789 microtubule associated tumor suppressor 1 Q9ULD2 Mitochondrion. Golgi apparatus (By similarity). Cell membrane (By similarity). Nucleus (By similarity). Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Plasma membrane (GO:0005886) 15123706,15123706,17081983/15123706,15123706 cytoplasm 22 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Holozoa MTUS2 HGNC:20595 microtubule associated tumor suppressor candidate 2 Q5JR59 Cytoplasm, cytoskeleton. Note=Associated with the microtubule network at the growing distal tip (the plus- end) of microtubules. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa MTX1 HGNC:7504 metaxin 1 Q13505 Membrane; Single-pass type I membrane protein (Potential). Mitochondrion outer membrane (By similarity). Mitochondrion (GO:0005739); Cytosol (GO:0005829); Perinuclear region (GO:0048471) 11454742,17510655,15598749,9045676,9045676 mitochondrion membrane 13 3 cytoplasm. mitochondrion multiple Theria Eukaryota Cell.Organisms MTX2 HGNC:7506 metaxin 2 O75431 Mitochondrion outer membrane. Mitochondrion (GO:0005739) 17510655,15598749 cytoplasm 14 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms MTX3 HGNC:24812 metaxin 3 Q5HYI7 Mitochondrion outer membrane (By similarity). nucleus 28 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms MUC1 HGNC:7508 mucin 1, cell surface associated P15941 Apical cell membrane; Single-pass type I membrane protein. Isoform 5: Secreted. Isoform 7: Secreted. Isoform 9: Secreted. Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 11483589,12377938,16888623,12939402,15020226,15221004,6094338,2351132,12939402,15020226,12955090,12750561,12939402,1556125,12939402,14998492 cytoplasm 10 1 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus. plasma membrane. secreted multiple Theria Theria Cell.Organisms MUC12 HGNC:7510 mucin 12, cell surface associated Q9UKN1 Membrane; Single-pass type I membrane protein (Potential). nucleus 24 1 nucleus nucleus NA NA Craniata MUC13 HGNC:7511 mucin 13, cell surface associated Q9H3R2 Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Secreted. Note=Also exists as a soluble form. Plasma membrane (GO:0005886) 11278439 cytoplasm 16 1 plasma membrane. secreted multiple Theria Chordata Euteleostomi MUC15 HGNC:14956 mucin 15, cell surface associated Q8N387 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential). Plasma membrane (GO:0005886) 12047385 plasma membrane 41 1 plasma membrane plasma membrane Eutheria Mammalia Euteleostomi MUC16 HGNC:15582 mucin 16, cell surface associated Q8WXI7 Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 12615972,12615972,12615972,12218296 nucleus 14 1 endoplasmic reticulum. golgi apparatus. plasma membrane. secreted multiple Amniota Amniota Amniota MUC17 HGNC:16800 mucin 17, cell surface associated Q685J3 Isoform 1: Cell membrane; Single-pass membrane protein. Isoform 2: Secreted (Probable). Cell membrane. Integral to membrane (GO:0016021) 11855812 plasma membrane 17 1 plasma membrane. secreted multiple Catarrhini Opisthokonta Euteleostomi MUC19 HGNC:14362 mucin 19, oligomeric Q7Z5P9 Secreted (Potential). secreted 53 0 secreted secreted Chordata Bilateria Holozoa MUC2 HGNC:7512 mucin 2, oligomeric mucus/gel-forming Q02817 Secreted. Note=In the intestine, secreted into the inner and outer mucus layers (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Nucleus (GO:0005634) 1985113,9668061,1985113,9668061,7926500,12582180,17081983 secreted 100 0 endoplasmic reticulum. golgi apparatus. nucleus. secreted multiple Chordata Bilateria Holozoa MUC20 HGNC:23282 mucin 20, cell surface associated Q8N307 Secreted (Potential). Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane. Plasma membrane (GO:0005886) 14565953 cytoplasm 12 0 cytoplasm cytoplasm Eutheria Eutheria Opisthokonta MUC21 HGNC:21661 mucin 21, cell surface associated Q5SSG8 Cell membrane; Single-pass type I membrane protein; Extracellular side. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Homininae Homininae Eutheria MUC22 HGNC:39755 mucin 22 E2RYF6 Membrane; Single-pass membrane protein (Potential). plasma membrane 9 1 plasma membrane plasma membrane NA NA Homo MUC3A HGNC:7513 mucin 3A, cell surface associated Q02505 Isoform 1: Membrane; Single-pass membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. nucleus 9 1 secreted secreted Euarchontoglires Mammalia Eukaryota MUC3B HGNC:13384 mucin 3B, cell surface associated Q9H195 Membrane; Single-pass membrane protein (Potential). secreted 22 1 secreted secreted NA NA NA MUC4 HGNC:7514 mucin 4, cell surface associated Q99102 Membrane; Single-pass membrane protein (Potential). Secreted. Mucin-4 beta chain: Cell membrane; Single- pass membrane protein. Mucin-4 alpha chain: Secreted. Isoform 3: Cell membrane; Single-pass membrane protein. Isoform 11: Secreted. Isoform 15: Secreted. Isoform 17: Cell membrane; Single-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12748185,10024507,12732353,10880978,10920259 secreted 8 1 plasma membrane. secreted multiple Human Chordata Cell.Organisms MUC5AC HGNC:7515 mucin 5AC, oligomeric mucus/gel-forming P98088 Secreted. secreted 100 0 secreted secreted Chordata Bilateria Holozoa MUC5B HGNC:7516 mucin 5B, oligomeric mucus/gel-forming Q9HC84 Secreted. secreted 100 0 secreted secreted Chordata Bilateria Holozoa MUC6 HGNC:7517 mucin 6, oligomeric mucus/gel-forming Q6W4X9 Secreted. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 7657100,7680650 secreted 100 0 cytoplasm. secreted multiple Chordata Bilateria Holozoa MUC7 HGNC:7518 mucin 7, secreted Q8TAX7 Secreted. Extracellular (GO:0005576) 11996097,7690757 secreted 100 0 secreted secreted Catarrhini Catarrhini Primates MUCL1 HGNC:30588 mucin-like 1 Q96DR8 Secreted (Probable). Membrane (Probable). Extracellular (GO:0005576) 12019145 secreted 80 0 secreted secreted Homininae Homininae Homo MUL1 HGNC:25762 mitochondrial E3 ubiquitin protein ligase 1 Q969V5 Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note=Transported in mitochondrion- derived vesicles from the mitochondrion to the peroxisome. cytoplasm 26 2 mitochondrion membrane. peroxisome multiple Euteleostomi Eukaryota Eukaryota MUM1 HGNC:29641 melanoma associated antigen (mutated) 1 Q2TAK8 Nucleus. Note=Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. nucleus 100 0 nucleus nucleus Chordata Chordata Olfactores MUM1L1 HGNC:26583 melanoma associated antigen (mutated) 1-like 1 Q5H9M0 nucleus 34 0 nucleus nucleus Euarchontoglires Tetrapoda Bilateria MURC HGNC:33742 muscle-related coiled-coil protein Q5BKX8 Cytoplasm, myofibril, sarcomere (By similarity). Cytoplasm (By similarity). Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (By similarity). cytoplasm 79 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata MUS81 HGNC:29814 MUS81 structure-specific endonuclease subunit Q96NY9 Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells. Nucleus (GO:0005634) 11741546 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota MUSK HGNC:7525 muscle, skeletal, receptor tyrosine kinase O15146 Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein (Probable). Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction (Probable). Plasma membrane (GO:0005886) 7546737 plasma membrane 30 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms MUSTN1 HGNC:22144 musculoskeletal, embryonic nuclear protein 1 Q8IVN3 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 82 0 nucleus nucleus NA NA NA MUT HGNC:7526 methylmalonyl CoA mutase P22033 Mitochondrion matrix. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 2567699,24458,15598749,14718574 mitochondrion 100 0 mitochondrion. secreted multiple Deuterostomia Cell.Organisms Cell.Organisms MUTYH HGNC:7527 mutY homolog Q9UIF7 Nucleus. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 11554314,11554314 nucleus 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms MVB12A HGNC:25153 multivesicular body subunit 12A Q96EY5 Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane; Peripheral membrane protein (Probable). Note=Colocalizes with F-actin. Some fraction may be nuclear. Nucleus (GO:0005634); Actin cytoskeleton (GO:0015629) 16895919,16895919 cytoplasm 17 0 cytoplasm. endosome. nucleus multiple Euteleostomi Euteleostomi Bilateria MVB12B HGNC:23368 multivesicular body subunit 12B Q9H7P6 Endosome (Probable). Late endosome membrane; Peripheral membrane protein (Probable). secreted 15 0 endosome endosome Bilateria Bilateria Metazoa MVD HGNC:7529 mevalonate (diphospho) decarboxylase P53602 Cytoplasm (GO:0005737); Peroxisome (GO:0005777) 12736493,12736493 cytoplasm 30 0 cytoplasm. peroxisome multiple Opisthokonta Cell.Organisms Cell.Organisms MVK HGNC:7530 mevalonate kinase Q03426 Cytoplasm. Cytoplasm (GO:0005737); Peroxisome (GO:0005777); Extracellular (GO:0005576) 11111075,11111075,6255462 cytoplasm 100 0 cytoplasm. peroxisome. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms MVP HGNC:7531 major vault protein Q14764 Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11986335,15133037,9628887 cytoplasm 16 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms MX1 HGNC:7532 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) P20591 Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Isoform 2: Cytoplasm. Nucleus. Note=Translocates into the nuclei of HSV-1 infected cells. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 8798556,10590150,1548781,11916975,10590150,1548781 cytoplasm 70 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Eukaryota Eukaryota MX2 HGNC:7533 myxovirus (influenza virus) resistance 2 (mouse) P20592 Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9405443,8798556,8798556,9405443 cytoplasm 53 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota MXD1 HGNC:6761 MAX dimerization protein 1 Q05195 Nucleus. Nucleus (GO:0005634) 11602341 nucleus 100 0 nucleus nucleus Theria Euteleostomi Holozoa MXD3 HGNC:14008 MAX dimerization protein 3 Q9BW11 Nucleus (By similarity). nucleus 80 0 nucleus nucleus Theria Euteleostomi Holozoa MXD4 HGNC:13906 MAX dimerization protein 4 Q14582 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 88 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa MXI1 HGNC:7534 MAX interactor 1, dimerization protein P50539 Nucleus. Nucleus (GO:0005634) 11498788,15121849 nucleus 100 0 nucleus nucleus Chordata Chordata Holozoa MXRA5 HGNC:7539 matrix-remodelling associated 5 Q9NR99 Secreted (Potential). plasma membrane 15 0 n/a n/a Tetrapoda Euteleostomi Cell.Organisms MXRA7 HGNC:7541 matrix-remodelling associated 7 P84157 Membrane; Single-pass membrane protein (Potential). nucleus 31 0 nucleus nucleus Euarchontoglires Euteleostomi Euteleostomi MXRA8 HGNC:7542 matrix-remodelling associated 8 Q9BRK3 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 14603461 plasma membrane 91 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi MYADM HGNC:7544 myeloid-associated differentiation marker Q96S97 Membrane; Multi-pass membrane protein (Probable). plasma membrane 34 8 plasma membrane plasma membrane Euarchontoglires Euteleostomi Craniata MYADML2 HGNC:34548 myeloid-associated differentiation marker-like 2 A6NDP7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 30 8 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata MYB HGNC:7545 v-myb avian myeloblastosis viral oncogene homolog P10242 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11779867,10378697,9447996 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota MYBBP1A HGNC:7546 MYB binding protein (P160) 1a Q9BQG0 Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) 10644447,9447996,15635413,11790298,15561729,19059367 nucleus 8 1 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota MYBL1 HGNC:7547 v-myb avian myeloblastosis viral oncogene homolog-like 1 P10243 Nucleus. Nucleus (GO:0005634) 9312094,8058310 nucleus 100 0 nucleus nucleus Chordata Bilateria Eukaryota MYBL2 HGNC:7548 v-myb avian myeloblastosis viral oncogene homolog-like 2 P10244 Nucleus. Nucleus (GO:0005634) 8142646,10744766,12645566,17081983 nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota MYBPC1 HGNC:7549 myosin binding protein C, slow type Q00872 Cytoplasm (GO:0005737) 12154082 secreted 8 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms MYBPC2 HGNC:7550 myosin binding protein C, fast type Q14324 Cytoplasm (GO:0005737) 12154082,17081983 nucleus 13 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms MYBPC3 HGNC:7551 myosin binding protein C, cardiac Q14896 Cytoplasm (GO:0005737); Myosin (GO:0016459) 9541104,12386147 cytoplasm 17 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms MYBPH HGNC:7552 myosin binding protein H Q13203 Cytoplasm (GO:0005737) 12154082 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms MYBPHL HGNC:30434 myosin binding protein H-like A2RUH7 secreted 15 0 secreted secreted NA NA Metazoa MYC HGNC:7553 v-myc avian myelocytomatosis viral oncogene homolog P01106 Nucleus, nucleoplasm. Nucleus, nucleolus. Mitochondrial membrane (GO:0005740); Nucleolus (GO:0005730); Nucleus (GO:0005634) 15210690,15723053,6431612,17157259,17072308,15210690,17081983 nucleus 100 0 mitochondrion membrane. nucleus multiple Euteleostomi Bilateria Eukaryota MYCBP HGNC:7554 MYC binding protein Q99417 Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 9797456,12414807,9797456,12414807,11483602,12223483 cytoplasm 49 0 cytoplasm. mitochondrion. nucleus multiple Chordata Eukaryota Eukaryota MYCBP2 HGNC:23386 MYC binding protein 2, E3 ubiquitin protein ligase O75592 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9689053,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms MYCBPAP HGNC:19677 MYCBP associated protein Q8TBZ2 Cytoplasm. Membrane (By similarity). Note=Colocalizes with MYCBP in the cytoplasm. Cytoplasm (GO:0005737) 12151104 nucleus 91 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota MYCL HGNC:7555 v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog P12524 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 3054516/2827002 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta MYCN HGNC:7559 v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog P04198 Nucleus. Nucleus (GO:0005634) 1425701,10407192,9856457,10597290 nucleus 100 0 nucleus nucleus Deuterostomia Opisthokonta Holozoa MYCT1 HGNC:23172 myc target 1 Q8N699 Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells. Nucleus (GO:0005634) 12673574 nucleus 100 2 nucleus nucleus Amniota Euteleostomi Euteleostomi MYD88 HGNC:7562 myeloid differentiation primary response 88 Q99836 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 9716450,9716450,,19898473,,,19898473, cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms MYEF2 HGNC:17940 myelin expression factor 2 Q9P2K5 Nucleus. Nucleus (GO:0005634) 2601707 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms MYEOV HGNC:7563 myeloma overexpressed Q96EZ4 secreted 77 2 n/a n/a Homininae Homininae Homo MYEOV2 HGNC:21314 myeloma overexpressed 2 Q8WXC6 secreted 35 0 secreted secreted Euteleostomi Bilateria Bilateria MYF5 HGNC:7565 myogenic factor 5 P13349 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9461343,10930450 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Bilateria MYF6 HGNC:7566 myogenic factor 6 (herculin) P23409 Nucleus. Nucleus (GO:0005634) 1945842 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria MYH1 HGNC:7567 myosin, heavy chain 1, skeletal muscle, adult P12882 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. Extracellular (GO:0005576); Mitochondrion (GO:0005739) 10077619,6304733,16188874,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. secreted multiple Opisthokonta Eukaryota Eukaryota MYH10 HGNC:7568 myosin, heavy chain 10, non-muscle P35580 Cytoplasm (GO:0005737) 12724421 cytoplasm 96 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH11 HGNC:7569 myosin, heavy chain 11, smooth muscle P35749 Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10850529,9715271,9715271 cytoplasm 88 0 cytoplasm. melanosome. nucleus. secreted multiple Opisthokonta Eukaryota Cell.Organisms MYH13 HGNC:7571 myosin, heavy chain 13, skeletal muscle Q9UKX3 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH14 HGNC:23212 myosin, heavy chain 14, non-muscle Q7Z406 cytoplasm 55 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH15 HGNC:31073 myosin, heavy chain 15 Q9Y2K3 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH2 HGNC:7572 myosin, heavy chain 2, skeletal muscle, adult Q9UKX2 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. Extracellular (GO:0005576); Nucleus (GO:0005634) 10579056,17081983 cytoplasm 100 0 cytoplasm. nucleus. secreted multiple Opisthokonta Eukaryota Eukaryota MYH3 HGNC:7573 myosin, heavy chain 3, skeletal muscle, embryonic P11055 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH4 HGNC:7574 myosin, heavy chain 4, skeletal muscle Q9Y623 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH6 HGNC:7576 myosin, heavy chain 6, cardiac muscle, alpha P13533 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. Cytoplasm (GO:0005737) 11512664 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH7 HGNC:7577 myosin, heavy chain 7, cardiac muscle, beta P12883 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. Extracellular (GO:0005576) 10579056 cytoplasm 100 0 cytoplasm. secreted multiple Opisthokonta Eukaryota Eukaryota MYH7B HGNC:15906 myosin, heavy chain 7B, cardiac muscle, beta A7E2Y1 Membrane; Peripheral membrane protein. cytoplasm 68 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH8 HGNC:7578 myosin, heavy chain 8, skeletal muscle, perinatal P13535 Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYH9 HGNC:7579 myosin, heavy chain 9, non-muscle P35579 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (By similarity). Cytoplasm (GO:0005737); Cytosol (GO:0005829); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11918549,16263121,14508515,15598749 cytoplasm 71 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Eukaryota MYL1 HGNC:7582 myosin, light chain 1, alkali; skeletal, fast P05976 Extracellular (GO:0005576) 16188874 cytoplasm 30 0 secreted secreted Tetrapoda Bilateria Cell.Organisms MYL10 HGNC:29825 myosin, light chain 10, regulatory Q9BUA6 cytoplasm 72 1 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms MYL12A HGNC:16701 myosin, light chain 12A, regulatory, non-sarcomeric P19105 Cytoskeleton (GO:0005856) 15561729 cytoplasm 44 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MYL12B HGNC:29827 myosin, light chain 12B, regulatory O14950 Cytoplasm (GO:0005737) 11942626 cytoplasm 44 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MYL2 HGNC:7583 myosin, light chain 2, regulatory, cardiac, slow P10916 Cytoplasm, myofibril, sarcomere, A band (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11891719,16555005 cytoplasm 95 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms MYL3 HGNC:7584 myosin, light chain 3, alkali; ventricular, skeletal, slow P08590 Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9990131,16188874 cytoplasm 31 0 cytoplasm. secreted multiple Theria Amniota Cell.Organisms MYL4 HGNC:7585 myosin, light chain 4, alkali; atrial, embryonic P12829 Cytoplasm (GO:0005737) 10373429 cytoplasm 30 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms MYL5 HGNC:7586 myosin, light chain 5, regulatory Q02045 cytoplasm 56 0 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms MYL6 HGNC:7587 myosin, light chain 6, alkali, smooth muscle and non-muscle P60660 Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737) 8856505,8856505 cytoplasm 35 0 cytoplasm cytoplasm Eutheria Bilateria Cell.Organisms MYL6B HGNC:29823 myosin, light chain 6B, alkali, smooth muscle and non-muscle P14649 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8856505,8856505 cytoplasm 31 0 cytoplasm. nucleus multiple Euarchontoglires Deuterostomia Cell.Organisms MYL7 HGNC:21719 myosin, light chain 7, regulatory Q01449 cytoplasm 51 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms MYL9 HGNC:15754 myosin, light chain 9, regulatory P24844 cytoplasm 44 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms MYLIP HGNC:21155 myosin regulatory light chain interacting protein Q8WY64 Cytoplasm (Probable). Cell membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 12826659,14550572,10593918,11162443,10593918 cytoplasm 71 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota MYLK HGNC:7590 myosin light chain kinase Q15746 Cytoplasm. Cell projection, lamellipodium. Cleavage furrow. Cytoplasm, cytoskeleton. Note=Localized to stress fibers during interphase and to the cleavage furrow during mitosis. Plasma membrane (GO:0005886) 11306802 cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms MYLK2 HGNC:16243 myosin light chain kinase 2 Q9H1R3 Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. cytoplasm 100 0 cytoplasm cytoplasm Theria Amniota Cell.Organisms MYLK3 HGNC:29826 myosin light chain kinase 3 Q32MK0 Cytoplasm (By similarity). cytoplasm 64 0 cytoplasm cytoplasm Amniota Bilateria Cell.Organisms MYLK4 HGNC:27972 myosin light chain kinase family, member 4 Q86YV6 cytoplasm 55 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms MYLPF HGNC:29824 myosin light chain, phosphorylatable, fast skeletal muscle Q96A32 cytoplasm 68 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms MYNN HGNC:14955 myoneurin Q9NPC7 Nucleus. Nucleus (GO:0005634) 10873615 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota MYO10 HGNC:7593 myosin X Q9HD67 Cytoplasm, cytosol. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Cell projection, filopodium tip. Cytoplasm, cell cortex. Cell projection, filopodium membrane; Peripheral membrane protein (By similarity). Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10984435,12055636,11278607,12055636 cytoplasm 29 1 cytoplasm. plasma membrane multiple Bilateria Eukaryota Eukaryota MYO15A HGNC:7594 myosin XVA Q9UKN7 Cell projection, stereocilium (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localizes to stereocilium tips in cochlear and vestibular hair cells (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11583965,15590698 cytoplasm 29 4 plasma membrane. secreted multiple Bilateria Eukaryota Eukaryota MYO16 HGNC:29822 myosin XVI Q9Y6X6 Cytoplasm. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells (By similarity). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 11588169,11588169 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Cell.Organisms MYO18A HGNC:31104 myosin XVIIIA Q92614 Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Cytoplasm, cytoskeleton. Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 12761286,12761286,12761286/17081983 cytoplasm 9 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Deuterostomia Bilateria Eukaryota MYO18B HGNC:18150 myosin XVIIIB Q8IUG5 Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634) 12547197,12547197/17081983 cytoplasm 6 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota MYO19 HGNC:26234 myosin XIX Q96H55 Cytoplasm, cytoskeleton. Mitochondrion outer membrane. Note=Probably associated with the outer membrane via its N-terminal mitochondrial targeting region. cytoplasm 24 0 cytoplasm cytoplasm Tetrapoda Euteleostomi NA MYO1A HGNC:7595 myosin IA Q9UBC5 Cytoplasm (GO:0005737) 10653589 cytoplasm 31 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MYO1B HGNC:7596 myosin IB O43795 Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11509238,8719884,11509238,11509238,8719884 cytoplasm 35 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MYO1C HGNC:7597 myosin IC O00159 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Cell membrane (By similarity). Cell projection, stereocilium membrane (By similarity). Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note=Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytoskeleton (GO:0005856) 8719884,8719884,17081983,16514417,15561729 cytoplasm 40 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota MYO1D HGNC:7598 myosin ID O94832 Cytoplasm (GO:0005737) cytoplasm 43 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MYO1E HGNC:7599 myosin IE Q12965 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction (By similarity). Note=Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles. Cytoplasm (GO:0005737) cytoplasm 33 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MYO1F HGNC:7600 myosin IF O00160 Cytoplasm (GO:0005737); Nucleus (GO:0005634) none,17081983,17081983 cytoplasm 32 0 nucleus nucleus Eukaryota Eukaryota NA MYO1G HGNC:13880 myosin IG B0I1T2 Cell membrane; Peripheral membrane protein. Note=Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. Plasma membrane (GO:0005886) 11544309 cytoplasm 38 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MYO1H HGNC:13879 myosin IH Q8N1T3 cytoplasm 38 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota MYO3A HGNC:7601 myosin IIIA Q8NEV4 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 10936054 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms MYO3B HGNC:15576 myosin IIIB Q8WXR4 Cytoplasm, cytoskeleton. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms MYO5A HGNC:7602 myosin VA (heavy chain 12, myoxin) Q9Y4I1 Cytoplasm (GO:0005737) 9207796 cytoplasm 25 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYO5B HGNC:7603 myosin VB Q9ULV0 Cytoplasm (GO:0005737) cytoplasm 23 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota MYO5C HGNC:7604 myosin VC Q9NQX4 Plasma membrane (GO:0005886); Zymogen granule (GO:0042588) 11870218,16278343 cytoplasm 23 1 plasma membrane plasma membrane Opisthokonta Eukaryota Eukaryota MYO6 HGNC:7605 myosin VI Q9UM54 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus (By similarity). Nucleus. Cytoplasm, perinuclear region. Membrane, clathrin-coated pit. Cell projection, ruffle membrane; Peripheral membrane protein. Isoform 3: Cytoplasmic vesicle, clathrin- coated vesicle membrane. Isoform 4: Cytoplasmic vesicle, clathrin- coated vesicle membrane. Cell projection, ruffle membrane. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9852149,9852149 cytoplasm 42 0 cytoplasm. golgi apparatus. nucleus multiple Human Bilateria Eukaryota MYO7A HGNC:7606 myosin VIIA Q13402 Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells. Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 7870171,15590698 cytoplasm 54 0 cytoplasm cytoplasm Bilateria Eukaryota NA MYO7B HGNC:7607 myosin VIIB Q6PIF6 Apical cell membrane (By similarity). Cytoplasm (GO:0005737) 11401444 cytoplasm 39 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota MYO9A HGNC:7608 myosin IXA B2RTY4 Membrane; Single-pass membrane protein (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) ,17081983 cytoplasm 34 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota MYO9B HGNC:7609 myosin IXB Q13459 Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8907710,8907710 cytoplasm 22 1 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota MYOC HGNC:7610 myocilin, trabecular meshwork inducible glucocorticoid response Q99972 Rough endoplasmic reticulum. Secreted. Cell projection, cilium. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11807810,10990486,12019210 secreted 31 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. secreted multiple Euteleostomi Euteleostomi Bilateria MYOCD HGNC:16067 myocardin Q8IZQ8 Nucleus (By similarity). Nucleus (GO:0005634) 11439182 nucleus 81 0 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta MYOD1 HGNC:7611 myogenic differentiation 1 P15172 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9407021,16858404,10583555 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria MYOF HGNC:3656 myoferlin Q9NZM1 Cell membrane; Single-pass type II membrane protein. Nucleus membrane; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Concentrated at the membrane sites of both myoblast- myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels (By similarity). Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures. Nucleus (GO:0005634);Plasma membrane (GO:0005886); Nucleus (GO:0005634); Nucleolus (GO:0005730) 17081983/10607832,10607832,17081983,11790298 cytoplasm 25 1 nucleus. nucleus membrane. plasma membrane multiple Bilateria Eukaryota Eukaryota MYOG HGNC:7612 myogenin (myogenic factor 4) P15173 Nucleus. Nucleus (GO:0005634) 2163343 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria MYOM1 HGNC:7613 myomesin 1 P52179 Cytoplasm, myofibril, sarcomere, M line (By similarity). cytoplasm 85 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms MYOM2 HGNC:7614 myomesin 2 P54296 Cytoplasm, myofibril, sarcomere, M line (By similarity). Cytoplasm (GO:0005737) 9933576 cytoplasm 27 0 cytoplasm cytoplasm Chordata Chordata NA MYOM3 HGNC:26679 myomesin 3 Q5VTT5 Cytoplasm, myofibril, sarcomere, M line (By similarity). cytoplasm 79 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms MYOT HGNC:12399 myotilin Q9UBF9 Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Sarcomeric, also localized to the sarcolemma. Colocalizes with MYOZ1 at the Z-lines in skeletal muscle. Plasma membrane (GO:0005886) 10369880 secreted 13 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Metazoa MYOZ1 HGNC:13752 myozenin 1 Q9NP98 Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle. Cytoplasm (GO:0005737) 11171996 cytoplasm 28 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata MYOZ2 HGNC:1330 myozenin 2 Q9NPC6 Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle (By similarity). Cytoplasm (GO:0005737) 11171996 cytoplasm 85 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata MYOZ3 HGNC:18565 myozenin 3 Q8TDC0 Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Localized at the Z-line of skeletal muscle (By similarity). Cytoplasm (GO:0005737) 11842093 cytoplasm 70 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Euteleostomi MYPN HGNC:23246 myopalladin Q86TC9 Cytoplasm. Nucleus (By similarity). Cytoplasm, myofibril, sarcomere. Note=Bound to sarcomere both at the Z-line periphery and in the central I-band region. Nucleus (GO:0005634) 11309420 plasma membrane 12 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa MYPOP HGNC:20178 Myb-related transcription factor, partner of profilin Q86VE0 Nucleus (By similarity). Nucleus (GO:0005634) 15615774 nucleus 83 0 nucleus nucleus Theria Tetrapoda Bilateria MYRF HGNC:1181 myelin regulatory factor Q9Y2G1 Membrane; Single-pass membrane protein (Potential). Nucleus (By similarity). secreted 21 1 secreted secreted Bilateria Eukaryota Cell.Organisms MYRFL HGNC:26316 myelin regulatory factor-like Q96LU7 Membrane; Single-pass membrane protein (Potential). nucleus 53 1 nucleus nucleus Bilateria Eukaryota Cell.Organisms MYRIP HGNC:19156 myosin VIIA and Rab interacting protein Q8NFW9 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cytoplasmic vesicle, secretory vesicle (By similarity). Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments (By similarity). Endosome (GO:0005768) 11964381 cytoplasm 41 1 endosome endosome Euteleostomi Euteleostomi Eumetazoa MYSM1 HGNC:29401 Myb-like, SWIRM and MPN domains 1 Q5VVJ2 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota MYT1 HGNC:7622 myelin transcription factor 1 Q01538 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12524179,12524179 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa MYT1L HGNC:7623 myelin transcription factor 1-like Q9UL68 Nucleus (By similarity). Nucleus (GO:0005634) 9373037 nucleus 92 0 nucleus nucleus Deuterostomia Bilateria Eukaryota MYZAP HGNC:43444 myocardial zonula adherens protein P0CAP1 Cytoplasm, cytoskeleton (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, myofibril, sarcomere, I band (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity). secreted 17 0 secreted secreted NA NA Holozoa MZB1 HGNC:30125 marginal zone B and B1 cell-specific protein Q8WU39 Isoform 1: Endoplasmic reticulum lumen (By similarity). Secreted. Isoform 2: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus. endoplasmic reticulum 96 0 cytoplasm. secreted multiple NA NA Eumetazoa MZF1 HGNC:13108 myeloid zinc finger 1 P28698 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15541732,15528990,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota MZT1 HGNC:33830 mitotic spindle organizing protein 1 Q08AG7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota MZT2A HGNC:33187 mitotic spindle organizing protein 2A Q6P582 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa MZT2B HGNC:25886 mitotic spindle organizing protein 2B Q6NZ67 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa N4BP1 HGNC:29850 NEDD4 binding protein 1 O75113 Nucleus, nucleolus (By similarity). Nucleus, PML body (By similarity). Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity). nucleus 77 0 nucleus nucleus Chordata Chordata Cell.Organisms N4BP2 HGNC:29851 NEDD4 binding protein 2 Q86UW6 Cytoplasm (By similarity). Cytoplasm (GO:0005737);Nucleus (GO:0005634) 11717310/17081983 cytoplasm 18 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms N4BP2L1 HGNC:25037 NEDD4 binding protein 2-like 1 Q5TBK1 nucleus 17 0 nucleus nucleus Tetrapoda Cell.Organisms Cell.Organisms N4BP2L2 HGNC:26916 NEDD4 binding protein 2-like 2 Q92802 nucleus 51 0 nucleus nucleus NA NA Cell.Organisms N4BP3 HGNC:29852 NEDD4 binding protein 3 O15049 Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023) 11717310,11717310 cytoplasm 29 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria N6AMT1 HGNC:16021 N-6 adenine-specific DNA methyltransferase 1 (putative) Q9Y5N5 mitochondrion 15 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms N6AMT2 HGNC:27351 N-6 adenine-specific DNA methyltransferase 2 (putative) Q8WVE0 cytoplasm 31 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota NAA10 HGNC:18704 N(alpha)-acetyltransferase 10, NatA catalytic subunit P41227 Cytoplasm. Nucleus. Note=According to PubMed:12464182 it is cytoplasmic. According to PubMed:15496142, it is nuclear and cytoplasmic. Also present in the free cytosolic and cytoskeleton-bound polysomes. Cytoplasm (GO:0005737) 12888564 cytoplasm 95 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms NA NAA11 HGNC:28125 N(alpha)-acetyltransferase 11, NatA catalytic subunit Q9BSU3 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16638120,16638120 cytoplasm 79 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NAA15 HGNC:30782 N(alpha)-acetyltransferase 15, NatA auxiliary subunit Q9BXJ9 Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12140756,12140756/17081983,17081983 cytoplasm 24 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms NAA16 HGNC:26164 N(alpha)-acetyltransferase 16, NatA auxiliary subunit Q6N069 cytoplasm 24 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms NAA20 HGNC:15908 N(alpha)-acetyltransferase 20, NatB catalytic subunit P61599 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 12888564,17081983 cytoplasm 35 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms NAA25 HGNC:25783 N(alpha)-acetyltransferase 25, NatB auxiliary subunit Q14CX7 Cytoplasm. cytoplasm 100 1 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota NAA30 HGNC:19844 N(alpha)-acetyltransferase 30, NatC catalytic subunit Q147X3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms NAA35 HGNC:24340 N(alpha)-acetyltransferase 35, NatC auxiliary subunit Q5VZE5 Cytoplasm. cytoplasm 100 2 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota NAA38 HGNC:28212 N(alpha)-acetyltransferase 38, NatC auxiliary subunit Q9BRA0 Cytoplasm. Nucleus. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) /10523320,10523320 nucleus 32 0 cytoplasm. nucleus multiple NA Eukaryota Eukaryota NAA40 HGNC:25845 N(alpha)-acetyltransferase 40, NatD catalytic subunit Q86UY6 cytoplasm 50 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota NAA50 HGNC:29533 N(alpha)-acetyltransferase 50, NatE catalytic subunit Q9GZZ1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms NAA60 HGNC:25875 N(alpha)-acetyltransferase 60, NatF catalytic subunit Q9H7X0 Golgi apparatus membrane. cytoplasm 16 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms NAAA HGNC:736 N-acylethanolamine acid amidase Q02083 Lysosome (Probable). Lysosome (GO:0005764); Cytoplasm (GO:0005737) 10610717,10610717 secreted 53 0 cytoplasm. lysosome multiple Deuterostomia Eukaryota Eukaryota NAALAD2 HGNC:14526 N-acetylated alpha-linked acidic dipeptidase 2 Q9Y3Q0 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 10085079 plasma membrane 27 1 plasma membrane plasma membrane Opisthokonta Cell.Organisms Cell.Organisms NAALADL1 HGNC:23536 N-acetylated alpha-linked acidic dipeptidase-like 1 Q9UQQ1 Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane. Plasma membrane (GO:0005886) 9388249 plasma membrane 100 1 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms NAALADL2 HGNC:23219 N-acetylated alpha-linked acidic dipeptidase-like 2 Q58DX5 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 10 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms NAB1 HGNC:7626 NGFI-A binding protein 1 (EGR1 binding protein 1) Q13506 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7624335,9418898,17081983,17081983 nucleus 91 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa NAB2 HGNC:7627 NGFI-A binding protein 2 (EGR1 binding protein 2) Q15742 Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity). Nucleus (GO:0005634);Cytoplasm (GO:0005737) 8649813/17081983 nucleus 94 0 cytoplasm. nucleus multiple Human Human Metazoa NABP1 HGNC:26232 nucleic acid binding protein 1 Q96AH0 Nucleus. Note=Localizes to nuclear foci following DNA damage. nucleus 100 0 nucleus nucleus Chordata Cell.Organisms Cell.Organisms NABP2 HGNC:28412 nucleic acid binding protein 2 Q9BQ15 Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment. nucleus 100 0 nucleus nucleus Chordata Cell.Organisms Cell.Organisms NACA HGNC:7629 nascent polypeptide-associated complex alpha subunit E9PAV3 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Ribosome (GO:0005840) 9488445,17081983,10982809,10982809 nucleus 29 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NACA2 HGNC:23290 nascent polypeptide-associated complex alpha subunit 2 Q9H009 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 10982809,7622554 nucleus 53 0 cytoplasm cytoplasm NA NA Eukaryota NACAD HGNC:22196 NAC alpha domain containing O15069 Cytoplasm (By similarity). Nucleus (By similarity). plasma membrane 24 0 n/a n/a Eukaryota Eukaryota Cell.Organisms NACC1 HGNC:20967 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing Q96RE7 Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation (By similarity). Nucleus (GO:0005634) 11906783 nucleus 20 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eukaryota NACC2 HGNC:23846 NACC family member 2, BEN and BTB (POZ) domain containing Q96BF6 nucleus 22 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota NADK HGNC:29831 NAD kinase O95544 Cytoplasm (GO:0005737) 11594753 mitochondrion 36 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms NADK2 HGNC:26404 NAD kinase 2, mitochondrial Q4G0N4 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota NADSYN1 HGNC:29832 NAD synthetase 1 Q6IA69 cytoplasm 49 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms NAE1 HGNC:621 NEDD8 activating enzyme E1 subunit 1 Q13564 Cell membrane. Note=Colocalizes with APP in lipid rafts. Cytoplasm (GO:0005737) 8626687 nucleus 25 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms NAF1 HGNC:25126 nuclear assembly factor 1 ribonucleoprotein Q96HR8 Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). Cytoplasm (GO:0005737) 17081983 plasma membrane 17 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota NAGA HGNC:7631 N-acetylgalactosaminidase, alpha- P17050 Lysosome. Lysosome (GO:0005764) 10704524 secreted 25 0 lysosome lysosome Bilateria Cell.Organisms Cell.Organisms NAGK HGNC:17174 N-acetylglucosamine kinase Q9UJ70 cytoplasm 52 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms NAGLU HGNC:7632 N-acetylglucosaminidase, alpha P54802 Lysosome. Lysosome (GO:0005764) 8776591 cytoplasm 37 0 lysosome lysosome Bilateria Cell.Organisms Cell.Organisms NAGPA HGNC:17378 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Q9UK23 Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Note=Cis/medial Golgi. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 10551838,11408573,3019310,11408573 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane. plasma membrane multiple Deuterostomia Cell.Organisms Cell.Organisms NAGS HGNC:17996 N-acetylglutamate synthase Q8N159 Mitochondrion matrix. Mitochondrion (GO:0005739) 12594532,12754705 mitochondrion 100 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms NAIF1 HGNC:25446 nuclear apoptosis inducing factor 1 Q69YI7 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi NAIP HGNC:7634 NLR family, apoptosis inhibitory protein Q13075 cytoplasm 10 2 cytoplasm cytoplasm NA NA NA NALCN HGNC:19082 sodium leak channel, non-selective Q8IZF0 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) vacuole membrane 6 22 vacuole membrane vacuole membrane Opisthokonta Opisthokonta Cell.Organisms NAMPT HGNC:30092 nicotinamide phosphoribosyltransferase P43490 Cytoplasm (By similarity). Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8289818,15124023,12555668,12782293,12782293 cytoplasm 95 0 cytoplasm. nucleus. secreted multiple Euteleostomi Cell.Organisms Cell.Organisms NANOG HGNC:20857 Nanog homeobox Q9H9S0 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Euteleostomi Metazoa NANOGNB HGNC:24958 NANOG neighbor homeobox Q7Z5D8 Nucleus (By similarity). nucleus 73 0 nucleus nucleus Catarrhini Catarrhini Opisthokonta NANOS1 HGNC:23044 nanos homolog 1 (Drosophila) Q8WY41 Cytoplasm, perinuclear region. Cytoplasm. Note=Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells. Cytoplasm (GO:0005737) 12690449 cytoplasm 100 0 cytoplasm cytoplasm Theria Bilateria Metazoa NANOS2 HGNC:23292 nanos homolog 2 (Drosophila) P60321 Cytoplasm. Cytoplasm, P-body (By similarity). Cytoplasm, perinuclear region. Note=Localizes at P- bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. cytoplasm 71 0 cytoplasm cytoplasm Euarchontoglires Euteleostomi Metazoa NANOS3 HGNC:22048 nanos homolog 3 (Drosophila) P60323 Nucleus. Cytoplasm. Cytoplasmic granule (By similarity). Cytoplasm, P-body (By similarity). Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body (By similarity). cytoplasm 34 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Metazoa NANP HGNC:16140 N-acetylneuraminic acid phosphatase Q8TBE9 mitochondrion 15 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms NANS HGNC:19237 N-acetylneuraminic acid synthase Q9NR45 Cytoplasm (GO:0005737); Cytosol (GO:0005829) 10873658,693772,16263121 secreted 30 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms NAP1L1 HGNC:7637 nucleosome assembly protein 1-like 1 P55209 Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 8297347,14966293,17081983,15598749 nucleus 63 0 melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota NAP1L2 HGNC:7638 nucleosome assembly protein 1-like 2 Q9ULW6 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10932189,10932189 nucleus 39 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eukaryota NAP1L3 HGNC:7639 nucleosome assembly protein 1-like 3 Q99457 Nucleus (By similarity). Nucleus (GO:0005634) 8976385 nucleus 36 0 nucleus nucleus Eutheria Eutheria Eukaryota NAP1L4 HGNC:7640 nucleosome assembly protein 1-like 4 Q99733 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9325046,17081983,9325046,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NAP1L5 HGNC:19968 nucleosome assembly protein 1-like 5 Q96NT1 Nucleus (Potential). Cytoplasm (GO:0005737) 12383514 nucleus 29 0 cytoplasm cytoplasm Eutheria Eutheria Eukaryota NAPA HGNC:7641 N-ethylmaleimide-sensitive factor attachment protein, alpha P54920 Membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Lysosome (GO:0005764) 1601890,10075705,15542541 cytoplasm 76 0 cytoplasm. golgi apparatus. lysosome multiple Eukaryota Eukaryota Eukaryota NAPB HGNC:15751 N-ethylmaleimide-sensitive factor attachment protein, beta Q9H115 Membrane; Peripheral membrane protein (By similarity). Integral to membrane (GO:0016021) 8455721 cytoplasm 70 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota NAPEPLD HGNC:21683 N-acyl phosphatidylethanolamine phospholipase D Q6IQ20 Membrane (By similarity). cytoplasm 34 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms NAPG HGNC:7642 N-ethylmaleimide-sensitive factor attachment protein, gamma Q99747 Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Endosome (GO:0005768) 9165027,1601890,9165027,12554740,12554740 cytoplasm 64 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms NAPRT1 HGNC:30450 nicotinate phosphoribosyltransferase domain containing 1 Q6XQN6 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 17081983 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms NAPSA HGNC:13395 napsin A aspartic peptidase O96009 Secreted (Potential). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 10580106,10580106 secreted 30 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms NARF HGNC:29916 nuclear prelamin A recognition factor Q9UHQ1 Nucleus. Nucleus (GO:0005634) 10514485 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms NARFL HGNC:14179 nuclear prelamin A recognition factor-like Q9H6Q4 nucleus 36 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms NARG2 HGNC:29885 NMDA receptor regulated 2 Q659A1 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15606750,15606750 nucleus 73 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eumetazoa NARS HGNC:7643 asparaginyl-tRNA synthetase O43776 Cytoplasm. Cytoplasm (GO:0005737) 9801298 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms NARS2 HGNC:26274 asparaginyl-tRNA synthetase 2, mitochondrial (putative) Q96I59 Mitochondrion matrix (By similarity). mitochondrion 31 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms NASP HGNC:7644 nuclear autoantigenic sperm protein (histone-binding) P49321 Cytoplasm (By similarity). Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12509435,12509435,17081983/12509435,12509435/8724350,12509435,12509435,8363049/17081983,17081983 nucleus 38 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota NAT1 HGNC:7645 N-acetyltransferase 1 (arylamine N-acetyltransferase) P18440 Cytoplasm. Cytoplasm (GO:0005737) 11470991 cytoplasm 100 0 cytoplasm cytoplasm Amniota Cell.Organisms Cell.Organisms NAT10 HGNC:29830 N-acetyltransferase 10 (GCN5-related) Q9H0A0 Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. Nucleus (GO:0005634) 14592445 nucleus 100 1 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms NAT14 HGNC:28918 N-acetyltransferase 14 (GCN5-related, putative) Q8WUY8 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) 10873651 secreted 34 1 nucleus nucleus Eutheria Tetrapoda Tetrapoda NAT16 HGNC:22030 N-acetyltransferase 16 (GCN5-related, putative) Q8N8M0 cytoplasm 34 0 cytoplasm cytoplasm Catarrhini Euteleostomi Holozoa NAT2 HGNC:7646 N-acetyltransferase 2 (arylamine N-acetyltransferase) P11245 Cytoplasm. Cytoplasm (GO:0005737) 1441598 cytoplasm 100 0 cytoplasm cytoplasm Human Human Cell.Organisms NAT6 HGNC:30252 N-acetyltransferase 6 (GCN5-related) Q93015 Cytoplasm. Cytoplasm (GO:0005737) 10644992 cytoplasm 100 0 cytoplasm cytoplasm NA NA NA NAT8 HGNC:18069 N-acetyltransferase 8 (GCN5-related, putative) Q9UHE5 Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (GO:0005794) 1139715 golgi apparatus membrane 22 2 golgi apparatus golgi apparatus Tetrapoda Cell.Organisms Cell.Organisms NAT8B HGNC:30235 N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene) Q9UHF3 Membrane; Single-pass membrane protein (Potential). golgi apparatus membrane 24 2 golgi apparatus membrane golgi apparatus membrane NA NA NA NAT8L HGNC:26742 N-acetyltransferase 8-like (GCN5-related, putative) Q8N9F0 Cytoplasm. Membrane; Single-pass membrane protein (Potential). Microsome membrane; Single-pass membrane protein (By similarity). Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single- pass membrane protein (By similarity). Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. golgi apparatus membrane 16 1 cytoplasm. mitochondrion membrane multiple Tetrapoda Cell.Organisms Cell.Organisms NAT9 HGNC:23133 N-acetyltransferase 9 (GCN5-related, putative) Q9BTE0 cytoplasm 41 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms NAV1 HGNC:15989 neuron navigator 1 Q8NEY1 Cytoplasm, cytoskeleton (By similarity). Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12062803,17081983 cytoplasm 96 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa NAV2 HGNC:15997 neuron navigator 2 Q8IVL1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12062803,12214280,12214280,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota NAV3 HGNC:15998 neuron navigator 3 Q8IVL0 Nucleus outer membrane (By similarity). Nucleus (GO:0005634) 12062803 nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota NBAS HGNC:15625 neuroblastoma amplified sequence A2RRP1 Cytoplasm. Mitochondrion (GO:0005739) 15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Deuterostomia Eukaryota Eukaryota NBEA HGNC:7648 neurobeachin Q8NFP9 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11102458,11102458,10501977,11102458,11102458 endoplasmic reticulum 23 2 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms NBEAL1 HGNC:20681 neurobeachin-like 1 Q6ZS30 Lysosome (GO:0005764) 15193433 endoplasmic reticulum 45 0 lysosome lysosome Deuterostomia Eukaryota Cell.Organisms NBEAL2 HGNC:31928 neurobeachin-like 2 Q6ZNJ1 Endoplasmic reticulum. endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Eukaryota Cell.Organisms NBL1 HGNC:7650 neuroblastoma 1, DAN family BMP antagonist P41271 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9516839,9516839 secreted 100 0 cytoplasm. secreted multiple Eutheria Bilateria Eumetazoa NBN HGNC:7652 nibrin O60934 Nucleus (By similarity). Nucleus, PML body. Chromosome, telomere (By similarity). Note=Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity). Nucleus (GO:0005634); Extracellular (GO:0005576); Nucleolus (GO:0005730) 9590180,11809878,12433983,12679336,14718574,15733840 nucleus 64 0 nucleus. secreted multiple Chordata Eukaryota Eukaryota NBPF1 HGNC:26088 neuroblastoma breakpoint family, member 1 Q3BBV0 Cytoplasm. Cytoplasm (GO:0005737) 16079250 cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Catarrhini NA NBPF10 HGNC:31992 neuroblastoma breakpoint family, member 10 Q6P3W6 Cytoplasm (Probable). cytoplasm 94 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi NBPF11 HGNC:31993 neuroblastoma breakpoint family, member 11 Q86T75 Cytoplasm (Probable). Cytoplasm (GO:0005737) 16079250 cytoplasm 93 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi NBPF12 HGNC:24297 neuroblastoma breakpoint family, member 12 Q5TAG4 Cytoplasm (Probable). cytoplasm 89 1 cytoplasm cytoplasm NA NA Euteleostomi NBPF14 HGNC:25232 neuroblastoma breakpoint family, member 14 Q5TI25 Cytoplasm (Probable). Cytoplasm (GO:0005737) 16079250 cytoplasm 89 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi NBPF15 HGNC:28791 neuroblastoma breakpoint family, member 15 Q8N660 Cytoplasm (Probable). Cytoplasm (GO:0005737) 16079250 cytoplasm 90 0 cytoplasm cytoplasm Catarrhini Catarrhini NA NBPF20 HGNC:32000 neuroblastoma breakpoint family, member 20 Q3BBV1 Cytoplasm (Probable). cytoplasm 91 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi NBPF26 HGNC:49571 neuroblastoma breakpoint family, member 26 B4DH59 cytoplasm 82 0 cytoplasm cytoplasm NA NA NA NBPF3 HGNC:25076 neuroblastoma breakpoint family, member 3 Q9H094 Cytoplasm (Probable). Cytoplasm (GO:0005737) 16381901,16079250 cytoplasm 70 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi NBPF4 HGNC:26550 neuroblastoma breakpoint family, member 4 Q96M43 Cytoplasm (Probable). cytoplasm 52 0 cytoplasm cytoplasm Human Eutheria Euteleostomi NBPF6 HGNC:31988 neuroblastoma breakpoint family, member 6 Q5VWK0 Cytoplasm (Probable). cytoplasm 52 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi NBPF8 HGNC:31990 neuroblastoma breakpoint family, member 8 Q3BBV2 Cytoplasm (Probable). Cytoplasm (GO:0005737) 16079250 cytoplasm 91 0 cytoplasm cytoplasm NA NA Euteleostomi NBPF9 HGNC:31991 neuroblastoma breakpoint family, member 9 Q3BBW0 Cytoplasm (Probable). cytoplasm 88 0 cytoplasm cytoplasm NA NA Euteleostomi NBR1 HGNC:6746 neighbor of BRCA1 gene 1 Q14596 Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line (By similarity). Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation. Cytoplasm (GO:0005737) 11856312 golgi apparatus 18 0 cytoplasm. lysosome multiple NA NA Eukaryota NCALD HGNC:7655 neurocalcin delta P61601 Cytoplasm (GO:0005737) 11964161 cytoplasm 19 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms NCAM1 HGNC:7656 neural cell adhesion molecule 1 P13591 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 4: Cell membrane; Lipid-anchor, GPI- anchor (Potential). Isoform 5: Secreted. Isoform 6: Secreted (Potential). Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 11685193,3576199,11685193,3576199 plasma membrane 96 1 plasma membrane. secreted multiple Deuterostomia Bilateria NA NCAM2 HGNC:7657 neural cell adhesion molecule 2 O15394 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12538518 plasma membrane 100 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms NCAN HGNC:2465 neurocan O14594 Secreted (By similarity). Extracellular (GO:0005576) 9795216 secreted 64 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms NCAPD2 HGNC:24305 non-SMC condensin I complex, subunit D2 Q15021 Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 12138188,17081983,12138188,17081983,15561729,15598749 nucleus 15 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota NCAPD3 HGNC:28952 non-SMC condensin II complex, subunit D3 P42695 Nucleus. Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15635413,15561729,15598749,17081983 nucleus 100 0 mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota NCAPG HGNC:24304 non-SMC condensin I complex, subunit G Q9BPX3 Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15148359,15148359 nucleus 83 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NCAPG2 HGNC:21904 non-SMC condensin II complex, subunit G2 Q86XI2 Nucleus. nucleus 100 4 nucleus nucleus Euteleostomi Eukaryota Eukaryota NCAPH HGNC:1112 non-SMC condensin I complex, subunit H Q15003 Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. Nucleolus (GO:0005730); Kinetochore (GO:0000776); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11694586,15561729,17081983,17081983 nucleus 93 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NCAPH2 HGNC:25071 non-SMC condensin II complex, subunit H2 Q6IBW4 Nucleus. Chromosome. Note=Distributed along the arms of chromosomes assembled in vivo and in vitro. nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota NCBP1 HGNC:7658 nuclear cap binding protein subunit 1, 80kDa Q09161 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8069914,7937105,17081983,17081983 nucleus 78 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NCBP2 HGNC:7659 nuclear cap binding protein subunit 2, 20kDa P52298 Nucleus. Cytoplasm. Nucleus (GO:0005634) 8601613 nucleus 27 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms NCBP2L HGNC:31795 nuclear cap binding protein subunit 2-like A6PVI3 nucleus 18 0 nucleus nucleus Human Catarrhini Eukaryota NCCRP1 HGNC:33739 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) Q6ZVX7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria NCDN HGNC:17597 neurochondrin Q9UBB6 Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons. Cytoplasm (GO:0005737) 14559245 secreted 74 3 cytoplasm cytoplasm Deuterostomia Eukaryota Opisthokonta NCEH1 HGNC:29260 neutral cholesterol ester hydrolase 1 Q6PIU2 Membrane; Single-pass type II membrane protein (Probable). Microsome (By similarity). secreted 24 2 n/a n/a Cell.Organisms Cell.Organisms Cell.Organisms NCF1 HGNC:7660 neutrophil cytosolic factor 1 P14598 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm NA NA NA NCF2 HGNC:7661 neutrophil cytosolic factor 2 P19878 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12169629,9121467,8257426 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms NCF4 HGNC:7662 neutrophil cytosolic factor 4, 40kDa Q15080 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8280052,8147882,8839867,8670049,8147882,8280052,8670049,9914162 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota NCK1 HGNC:7664 NCK adaptor protein 1 P16333 Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9010224,9010224,9024622 nucleus 27 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Bilateria Eukaryota NCK2 HGNC:7665 NCK adaptor protein 2 O43639 Cytoplasm. Endoplasmic reticulum. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytoskeleton (GO:0005856) 10887126,10887126,10887126 peroxisome membrane 23 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Bilateria Eukaryota NCKAP1 HGNC:7666 NCK-associated protein 1 Q9Y2A7 Cell membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=At the interface between the lamellipodial actin meshwork and the membrane (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 14560022,15598749 cytoplasm 28 0 cytoplasm. mitochondrion multiple Bilateria Eukaryota Eukaryota NCKAP1L HGNC:4862 NCK-associated protein 1-like P55160 Cell membrane; Single-pass membrane protein; Cytoplasmic side (Probable). Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 1932118,15598749 cytoplasm 22 0 mitochondrion. plasma membrane multiple Bilateria Eukaryota Eukaryota NCKAP5 HGNC:29847 NCK-associated protein 5 O14513 cytoplasm 20 0 cytoplasm cytoplasm Theria Euteleostomi Bilateria NCKAP5L HGNC:29321 NCK-associated protein 5-like Q9HCH0 secreted 12 0 secreted secreted Eutheria Euteleostomi Bilateria NCKIPSD HGNC:15486 NCK interacting protein with SH3 domain Q9NZQ3 Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes. Nucleus (GO:0005634) 11241789 nucleus 100 3 nucleus nucleus Deuterostomia Eukaryota Opisthokonta NCL HGNC:7667 nucleolin P19338 Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9918513,10660576,15195518,15635413,11790298,17623812,10660576,19059367,12096904,17081983,9822633 nucleus 49 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms NCLN HGNC:26923 nicalin Q969V3 Endoplasmic reticulum membrane; Single-pass membrane protein. Plasma membrane (GO:0005886) 15257293 endoplasmic reticulum membrane 100 3 endoplasmic reticulum membrane. plasma membrane multiple Bilateria Eukaryota Cell.Organisms NCMAP HGNC:29332 noncompact myelin associated protein Q5T1S8 Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized mainly in the Schmidt- Lanterman incisures and paranodes of noncompact peripheral nerve myelin (By similarity). Integral to membrane (GO:0016021) plasma membrane 75 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Amniota NCOA1 HGNC:7668 nuclear receptor coactivator 1 Q15788 Nucleus (By similarity). Nucleus (GO:0005634) 10688660 nucleus 91 0 nucleus nucleus Amniota Euteleostomi Metazoa NCOA2 HGNC:7669 nuclear receptor coactivator 2 Q15596 Nucleus. Nucleus (GO:0005634) 8670870 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa NCOA3 HGNC:7670 nuclear receptor coactivator 3 Q9Y6Q9 Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11087842,11971985,16439211,11087842,11971985 nucleus 33 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa NCOA4 HGNC:7671 nuclear receptor coactivator 4 Q13772 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12068007,17081983,12068007 nucleus 49 0 cytoplasm. nucleus multiple Amniota Deuterostomia NA NCOA5 HGNC:15909 nuclear receptor coactivator 5 Q9HCD5 Nucleus. Nucleus (GO:0005634) 11113208,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa NCOA6 HGNC:15936 nuclear receptor coactivator 6 Q14686 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10567404,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria NCOA7 HGNC:21081 nuclear receptor coactivator 7 Q8NI08 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11971969,17081983 mitochondrion 45 0 cytoplasm. nucleus multiple Tetrapoda Opisthokonta Cell.Organisms NCOR1 HGNC:7672 nuclear receptor corepressor 1 O75376 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/10573424,12799135,17081983,12799135 nucleus 90 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Cell.Organisms NCOR2 HGNC:7673 nuclear receptor corepressor 2 Q9Y618 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,10077563,17000644,17081983,11013263,,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Cell.Organisms NCR1 HGNC:6731 natural cytotoxicity triggering receptor 1 O76036 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9730896,9314561 plasma membrane 27 1 plasma membrane plasma membrane Euarchontoglires Eutheria NA NCR2 HGNC:6732 natural cytotoxicity triggering receptor 2 O95944 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10049942 plasma membrane 19 1 plasma membrane plasma membrane Catarrhini Eutheria Craniata NCR3 HGNC:19077 natural cytotoxicity triggering receptor 3 O14931 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10941844,10941844 plasma membrane 100 1 cytoplasm. plasma membrane multiple Eutheria Tetrapoda NA NCR3LG1 HGNC:42400 natural killer cell cytotoxicity receptor 3 ligand 1 Q68D85 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane NA NA Craniata NCS1 HGNC:3953 neuronal calcium sensor 1 P62166 Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 11092894,14607934,12928444,12244129,12006624,11092894,12928444,12244129,12006624,11092894,14607934,12244129,12006624 cytoplasm 20 0 cytoplasm. golgi apparatus multiple Opisthokonta Eukaryota NA NCSTN HGNC:17091 nicastrin Q92542 Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10993067,12044882,12736250,12032140,12032140 plasma membrane 67 1 endoplasmic reticulum. golgi apparatus. lysosome. melanosome. plasma membrane multiple Bilateria Eukaryota Eukaryota NDC1 HGNC:25525 NDC1 transmembrane nucleoporin Q9BTX1 Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex. Nuclear membrane (GO:0005635); Endoplasmic reticulum (GO:0005783) 16600873,16600873 plasma membrane 20 6 endoplasmic reticulum. nucleus. nucleus membrane multiple Deuterostomia Bilateria Opisthokonta NDC80 HGNC:16909 NDC80 kinetochore complex component O14777 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. Kinetochore (GO:0000776); Nucleus (GO:0005634) 15824131,17363900,16732327,17093495,15561729,9315664 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota NDE1 HGNC:17619 nudE neurodevelopment protein 1 Q9NXR1 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF- dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis. Nucleus (GO:0005634); Centrosome (GO:0005813); Cytoplasm (GO:0005737) 12032826,12556484,10940388,12556484,16682949,12556484 cytoplasm 22 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta Eukaryota NDEL1 HGNC:17620 nudE neurodevelopment protein 1-like 1 Q9GZM8 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. Centrosome (GO:0005813); Axon (GO:0030424) 12556484,11163260 cytoplasm 21 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota NDFIP1 HGNC:17592 Nedd4 family interacting protein 1 Q9BT67 Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane (By similarity). Secreted. Note=Detected in exosomes and secreted via the exosomal pathway. Golgi apparatus (GO:0005794) 11748237 mitochondrion membrane 14 3 endosome membrane. golgi apparatus. secreted multiple Deuterostomia Bilateria Holozoa NDFIP2 HGNC:18537 Nedd4 family interacting protein 2 Q9NV92 Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023) 12796489,15252135,12796489,12796489,12796489,15252135 plasma membrane 29 3 cytoplasm. endoplasmic reticulum. endosome membrane. golgi apparatus. mitochondrion multiple Tetrapoda Bilateria Eumetazoa NDN HGNC:7675 necdin, melanoma antigen (MAGE) family member Q99608 Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1394972,11813259,10965153 nucleus 17 2 cytoplasm. nucleus multiple Eutheria Eutheria Opisthokonta NDNF HGNC:26256 neuron-derived neurotrophic factor Q8TB73 Secreted. secreted 100 0 secreted secreted Bilateria Bilateria Bilateria NDNL2 HGNC:7677 necdin-like 2 Q96MG7 Cytoplasm (By similarity). Nucleus. Chromosome, telomere (Probable). Nucleolus (GO:0005730) 15635413 nucleus 26 1 nucleus nucleus Chordata Eukaryota Eukaryota NDOR1 HGNC:29838 NADPH dependent diflavin oxidoreductase 1 Q9UHB4 Cytoplasm, perinuclear region. Note=Concentrated in perinuclear structure. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 10625700,12871939/10625700 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms NDP HGNC:7678 Norrie disease (pseudoglioma) Q00604 Secreted. Extracellular (GO:0005576) 9407136 secreted 100 0 secreted secreted Amniota Euteleostomi Bilateria NDRG1 HGNC:7679 N-myc downstream regulated 1 Q92597 Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10831399,17081983,10831399 cytoplasm 55 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms NDRG2 HGNC:14460 NDRG family member 2 Q9UN36 Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone (By similarity). Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Dendrite (GO:0030425) 11936845,15526377,15207261,15207261 cytoplasm 59 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota NDRG3 HGNC:14462 NDRG family member 3 Q9UGV2 Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 11936845/17081983 cytoplasm 58 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota NDRG4 HGNC:14466 NDRG family member 4 Q9ULP0 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 11936845,11352569,12755708 cytoplasm 100 0 cytoplasm cytoplasm Human Euteleostomi Eukaryota NDST1 HGNC:7680 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 P52848 Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794) 11792394 golgi apparatus membrane 100 1 golgi apparatus. golgi apparatus membrane multiple Bilateria Bilateria Cell.Organisms NDST2 HGNC:7681 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 P52849 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 12045103 golgi apparatus membrane 66 1 golgi apparatus golgi apparatus Bilateria Bilateria Cell.Organisms NDST3 HGNC:7682 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 O95803 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 12417402 golgi apparatus membrane 64 1 golgi apparatus golgi apparatus Bilateria Bilateria Cell.Organisms NDST4 HGNC:20779 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 Q9H3R1 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 66 1 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms NDUFA1 HGNC:7683 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa O15239 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Mitochondrion (GO:0005739) 10200266 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Amniota Bilateria Bilateria NDUFA10 HGNC:7684 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa O95299 Mitochondrion matrix. Mitochondrion (GO:0005739) none,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms NDUFA11 HGNC:20371 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa Q86Y39 Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side (By similarity). Mitochondrion (GO:0005739) 12611891 mitochondrion membrane 70 4 mitochondrion mitochondrion NA NA Bilateria NDUFA12 HGNC:23987 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 Q9UI09 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 10830904,12857734,15598749 mitochondrion 54 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms NDUFA13 HGNC:17194 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 Q9P0J0 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737) 12611891,12628925,15561729,10924506,12628925,12628925 mitochondrion 16 1 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Theria Eukaryota Eukaryota NDUFA2 HGNC:7685 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa O43678 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. mitochondrion 92 0 mitochondrion mitochondrion Chordata Eukaryota Eukaryota NDUFA3 HGNC:7686 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa O95167 Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion (GO:0005739) 9878551 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Theria Euteleostomi NA NDUFA4 HGNC:7687 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa O00483 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 9352085 nucleus 19 1 mitochondrion mitochondrion Euteleostomi Bilateria Opisthokonta NDUFA4L2 HGNC:29836 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 Q9NRX3 nucleus 8 1 nucleus nucleus Eutheria Euteleostomi Opisthokonta NDUFA5 HGNC:7688 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 Q16718 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 9021153,10343126 cytoplasm 64 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota NDUFA6 HGNC:7690 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa P56556 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 9425316 mitochondrion 67 0 mitochondrion mitochondrion Eukaryota Eukaryota NA NDUFA7 HGNC:7691 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa O95182 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 9878551 mitochondrion 17 0 mitochondrion mitochondrion Deuterostomia Bilateria NA NDUFA8 HGNC:7692 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa P51970 Mitochondrion. Mitochondrion intermembrane space. Mitochondrion (GO:0005739) 9860297,11349233,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota NDUFA9 HGNC:7693 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa Q16795 Mitochondrion matrix. Mitochondrion (GO:0005739) ,9878551,8486360,15250827, mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms NDUFAB1 HGNC:7694 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa O14561 Mitochondrion. Mitochondrion (GO:0005739) mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms NDUFAF1 HGNC:18828 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 Q9Y375 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11935339,9769214 mitochondrion 12 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms NDUFAF2 HGNC:28086 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 Q8N183 Mitochondrion. Mitochondrion (GO:0005739) 15774466 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota NDUFAF3 HGNC:29918 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 Q9BU61 Nucleus (By similarity). Mitochondrion inner membrane. mitochondrion 41 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms NDUFAF4 HGNC:21034 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 Q9P032 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Bilateria Eumetazoa NDUFAF5 HGNC:15899 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 Q5TEU4 Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane. golgi apparatus membrane 22 0 golgi apparatus membrane golgi apparatus membrane Eukaryota Cell.Organisms Cell.Organisms NDUFAF6 HGNC:28625 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 Q330K2 Isoform 1: Mitochondrion inner membrane. Isoform 2: Cytoplasm. Nucleus. mitochondrion 5 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms NDUFAF7 HGNC:28816 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 Q7L592 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms NDUFB1 HGNC:7695 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa O75438 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Integral to membrane (GO:0016021) mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Amniota Bilateria Bilateria NDUFB10 HGNC:7696 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa O96000 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 15598749 nucleus 9 0 mitochondrion mitochondrion Bilateria Bilateria Metazoa NDUFB11 HGNC:20372 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa Q9NX14 Mitochondrion inner membrane; Single-pass membrane protein (Potential). mitochondrion 9 1 mitochondrion mitochondrion Theria Bilateria NA NDUFB2 HGNC:7697 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa O95178 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. mitochondrion 59 1 mitochondrion mitochondrion Euteleostomi Bilateria Bilateria NDUFB3 HGNC:7698 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa O43676 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Deuterostomia Bilateria Bilateria NDUFB4 HGNC:7699 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa O95168 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Integral to membrane (GO:0016021); Mitochondrion (GO:0005739) ,15598749 mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Theria Bilateria Bilateria NDUFB5 HGNC:7700 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa O43674 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Mitochondrion (GO:0005739) none,15598749 mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Bilateria NDUFB6 HGNC:7701 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa O95139 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 7236204,9760212,15598749 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Chordata Chordata Deuterostomia NDUFB7 HGNC:7702 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa P17568 Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (Probable). Mitochondrion intermembrane space. Mitochondrion (GO:0005739) nucleus 34 0 mitochondrion mitochondrion Theria Eukaryota Eukaryota NDUFB8 HGNC:7703 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa O95169 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Mitochondrion (GO:0005739) mitochondrion membrane 100 2 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Opisthokonta NDUFB9 HGNC:7704 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa Q9Y6M9 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 10077726 nucleus 31 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota NDUFC1 HGNC:7705 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa O43677 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Mitochondrion (GO:0005739) mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Theria Amniota Euteleostomi NDUFC2 HGNC:7706 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa O95298 Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Mitochondrion (GO:0005739) mitochondrion membrane 100 2 mitochondrion membrane mitochondrion membrane Theria Bilateria Bilateria NDUFS1 HGNC:7707 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) P28331 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 11349233,15598749 mitochondrion 33 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms NDUFS2 HGNC:7708 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) O75306 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) ,9585441,15250827, mitochondrion 73 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms NDUFS3 HGNC:7710 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) O75489 Mitochondrion inner membrane. Mitochondrion (GO:0005739) ,none,15598749,15250827, cytoplasm 25 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms NDUFS4 HGNC:7711 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) O43181 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 12206907,15598749 mitochondrion 36 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms NDUFS5 HGNC:7712 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) O43920 Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (Probable). Mitochondrion intermembrane space (Potential). Mitochondrion (GO:0005739) nucleus 31 0 mitochondrion mitochondrion Euteleostomi Bilateria Metazoa NDUFS6 HGNC:7713 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) O75380 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) mitochondrion 10 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms NDUFS7 HGNC:7714 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) O75251 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 8938450,10330338 mitochondrion 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NDUFS8 HGNC:7715 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) O00217 Mitochondrion (Probable). Mitochondrion (GO:0005739); Nucleus (GO:0005634) ,9666055,15598749,15250827,,11955626 mitochondrion 91 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NDUFV1 HGNC:7716 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa P49821 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 9571201 mitochondrion 22 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms NDUFV2 HGNC:7717 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa P19404 Mitochondrion inner membrane. Mitochondrion (GO:0005739) ,7488192,15561729,15250827, mitochondrion 19 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms NDUFV3 HGNC:7719 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa P56181 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 9344673,8443212,15561729 secreted 13 0 mitochondrion. mitochondrion membrane multiple Amniota Euteleostomi Craniata NEB HGNC:7720 nebulin P20929 Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 8816284,16188874 cytoplasm 100 0 cytoplasm. secreted multiple Chordata Chordata Cell.Organisms NEBL HGNC:16932 nebulette O76041 Isoform 2: Cytoplasm. Cytoskeleton (GO:0005856) cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Eukaryota NECAB1 HGNC:20983 N-terminal EF-hand calcium binding protein 1 Q8N987 Cytoplasm (By similarity). cytoplasm 96 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa NECAB2 HGNC:23746 N-terminal EF-hand calcium binding protein 2 Q7Z6G3 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11641222 cytoplasm 82 0 cytoplasm cytoplasm Amniota Euteleostomi Holozoa NECAB3 HGNC:15851 N-terminal EF-hand calcium binding protein 3 Q96P71 Golgi apparatus. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794);Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 10833507,10833507,14697346/14697346,14697346 golgi apparatus 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Human Human Holozoa NECAP1 HGNC:24539 NECAP endocytosis associated 1 Q8NC96 Cytoplasmic vesicle, clathrin-coated vesicle membrane (By similarity). Cell membrane (By similarity). Note=Colocalizes with AP-2 at the plasma membrane (By similarity). cytoplasm 51 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota NECAP2 HGNC:25528 NECAP endocytosis associated 2 Q9NVZ3 Cytoplasmic vesicle, clathrin-coated vesicle membrane (By similarity). Cell membrane (By similarity). Note=Colocalizes with AP-2 at the plasma membrane (By similarity). cytoplasm 47 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota NEDD1 HGNC:7723 neural precursor cell expressed, developmentally down-regulated 1 Q8NHV4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NEDD4 HGNC:7727 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase P46934 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9073511,9182527,11342538,9405440,11342538 cytoplasm 61 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Eukaryota NEDD4L HGNC:7728 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Q96PU5 Cytoplasm. Note=May be recruited to exosomes by NDFIP1. Plasma membrane (GO:0005886); Perinuclear region (GO:0048471) 11562473,15217910,,18577513, cytoplasm 100 0 cytoplasm cytoplasm Bilateria Opisthokonta Eukaryota NEDD8 HGNC:7732 neural precursor cell expressed, developmentally down-regulated 8 Q15843 Nucleus. Note=Mainly nuclear. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9353319,10587588 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms NEDD9 HGNC:7733 neural precursor cell expressed, developmentally down-regulated 9 Q14511 Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 8668148,9020138,9584194,8668148,9584194,8668148,11118211,11782456,11438665,10866674,9584194,11827972,10490968,9584194 cytoplasm 28 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Deuterostomia Bilateria Eukaryota NEFH HGNC:7737 neurofilament, heavy polypeptide P12036 Cytoplasm (GO:0005737) 1688443 cytoplasm 27 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa NEFL HGNC:7739 neurofilament, light polypeptide P07196 Cytoplasm (GO:0005737) 9763415 cytoplasm 30 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA NEFM HGNC:7734 neurofilament, medium polypeptide P07197 Cytoplasm (GO:0005737) 8620924 cytoplasm 30 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms NEGR1 HGNC:17302 neuronal growth regulator 1 Q7Z3B1 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). cytoplasm 11 1 cytoplasm cytoplasm Euteleostomi Bilateria Metazoa NEIL1 HGNC:18448 nei endonuclease VIII-like 1 (E. coli) Q96FI4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin. Nucleus (GO:0005634) 12200441 nucleus 21 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms NEIL2 HGNC:18956 nei endonuclease VIII-like 2 (E. coli) Q969S2 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12097317,12097317,12097317 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Tetrapoda Cell.Organisms NEIL3 HGNC:24573 nei endonuclease VIII-like 3 (E. coli) Q8TAT5 Nucleus. Nucleus (GO:0005634) 12433996 nucleus 100 0 nucleus nucleus Theria Cell.Organisms Cell.Organisms NEK1 HGNC:7744 NIMA-related kinase 1 Q96PY6 Nucleus (Probable). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity). Nucleus (GO:0005634) cytoplasm 18 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NEK10 HGNC:18592 NIMA-related kinase 10 Q6ZWH5 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NEK11 HGNC:18593 NIMA-related kinase 11 Q8NG66 Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells. Nucleolus (GO:0005730) 15161910 nucleus 100 0 nucleus nucleus Mammalia Deuterostomia Cell.Organisms NEK2 HGNC:7745 NIMA-related kinase 2 P51955 Isoform 1: Nucleus. Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere (By similarity). Isoform 2: Cytoplasm. Isoform 4: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear. Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Centriole (GO:0005814) 9430639,11785960,11785960,15161910,16648845 cytoplasm 28 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms NEK3 HGNC:7746 NIMA-related kinase 3 P51956 Cytoplasm (By similarity). Cell projection, axon (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10224116,10224116 cytoplasm 20 0 cytoplasm. nucleus multiple Amniota Euteleostomi Cell.Organisms NEK4 HGNC:11399 NIMA-related kinase 4 P51957 Nucleus (Probable). nucleus 14 0 nucleus nucleus Chordata Eukaryota Cell.Organisms NEK5 HGNC:7748 NIMA-related kinase 5 Q6P3R8 cytoplasm 18 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms NEK6 HGNC:7749 NIMA-related kinase 6 Q9HC98 Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Co- localizes with APBB1 at the nuclear speckles. Co-localizes with PIN1 in the nucleus. Co-localizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10964517,10964517,16476580 cytoplasm 20 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms NEK7 HGNC:13386 NIMA-related kinase 7 Q8TDX7 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody. Cytoplasm (GO:0005737) 10964517 cytoplasm 21 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms NEK8 HGNC:13387 NIMA-related kinase 8 Q86SG6 Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Cell projection, cilium (By similarity). Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells. Cytoplasm (GO:0005737) 11864968 nucleus 21 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms NEK9 HGNC:18591 NIMA-related kinase 9 Q8TD19 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12101123,17081983,12101123 cytoplasm 16 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Cell.Organisms NELFA HGNC:12768 negative elongation factor complex member A Q9H3P2 Nucleus. Nucleus (GO:0005634) 11150502 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota NELFB HGNC:24324 negative elongation factor complex member B Q8WX92 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12612062,15530430,15342491,15185750,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota NELFCD HGNC:15934 negative elongation factor complex member C/D Q8IXH7 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12612062,14684750,14684750 nucleus 43 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota NELFE HGNC:13974 negative elongation factor complex member E P18615 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12612062/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria NA NELL1 HGNC:7750 NEL-like 1 (chicken) Q92832 Cytoplasm. Nucleus envelope. Secreted (By similarity). Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region. Extracellular (GO:0005576) 8975702 secreted 44 0 cytoplasm. secreted multiple Euteleostomi Bilateria Cell.Organisms NELL2 HGNC:7751 NEL-like 2 (chicken) Q99435 Secreted (By similarity). secreted 92 0 secreted secreted Euteleostomi Bilateria Cell.Organisms NEMF HGNC:10663 nuclear export mediator factor O60524 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9610721,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NENF HGNC:30384 neudesin neurotrophic factor Q9UMX5 Secreted, extracellular space (By similarity). Extracellular (GO:0005576) secreted 94 0 secreted secreted Euteleostomi Eukaryota Eukaryota NEO1 HGNC:7754 neogenin 1 Q92859 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9121761 plasma membrane 100 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms NES HGNC:7756 nestin P48681 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14625035,15127288,15117961,12836073,12832492,17081983,15117961,17081983 cytoplasm 14 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota NET1 HGNC:14592 neuroepithelial cell transforming 1 Q7Z628 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 49 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota NETO1 HGNC:13823 neuropilin (NRP) and tolloid (TLL)-like 1 Q8TDF5 Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 1: Secreted (Potential). Soluble fraction (GO:0005625) 11943477 secreted 16 1 secreted secreted Euteleostomi Euteleostomi Cell.Organisms NETO2 HGNC:14644 neuropilin (NRP) and tolloid (TLL)-like 2 Q8NC67 Membrane; Single-pass type I membrane protein (Potential). secreted 15 1 secreted secreted Euteleostomi Bilateria Holozoa NEU1 HGNC:7758 sialidase 1 (lysosomal sialidase) Q99519 Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. Lysosome (GO:0005764); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 9480870,11571282,9480870,11571282,9020182 cytoplasm 20 1 endoplasmic reticulum. lysosome. plasma membrane multiple Theria Cell.Organisms NA NEU2 HGNC:7759 sialidase 2 (cytosolic sialidase) Q9Y3R4 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10561456 cytoplasm 61 0 cytoplasm cytoplasm Amniota Amniota Cell.Organisms NEU3 HGNC:7760 sialidase 3 (membrane sialidase) Q9UQ49 Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886) 10861246 cytoplasm 32 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms NEU4 HGNC:21328 sialidase 4 Q8WWR8 Isoform 1: Membrane; Peripheral membrane protein. Isoform 2: Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N- glycosylation site is predicted from the sequence. Lysosome (GO:0005764); Cytoplasm (GO:0005737) 15213228,17081983 cytoplasm 30 0 cytoplasm. lysosome multiple Euteleostomi Euteleostomi Cell.Organisms NEURL1 HGNC:7761 neuralized E3 ubiquitin protein ligase 1 O76050 Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm, perinuclear region. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12213446,12213446,11997106 cytoplasm 30 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota NEURL1B HGNC:35422 neuralized E3 ubiquitin protein ligase 1B A8MQ27 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota NEURL2 HGNC:16156 neuralized E3 ubiquitin protein ligase 2 Q9BR09 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 87 0 cytoplasm cytoplasm Euteleostomi Bilateria Metazoa NEURL3 HGNC:25162 neuralized E3 ubiquitin protein ligase 3 Q96EH8 cytoplasm 26 0 cytoplasm cytoplasm Theria Euteleostomi NA NEURL4 HGNC:34410 neuralized E3 ubiquitin protein ligase 4 Q96JN8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). cytoplasm 100 0 cytoplasm cytoplasm Theria Bilateria Holozoa NEUROD1 HGNC:7762 neuronal differentiation 1 Q13562 Cytoplasm (By similarity). Nucleus. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12297313,12297313 nucleus 48 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa NEUROD2 HGNC:7763 neuronal differentiation 2 Q15784 Nucleus (By similarity). Nucleus (GO:0005634) 9748526 nucleus 98 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa NEUROD4 HGNC:13802 neuronal differentiation 4 Q9HD90 Nucleus (Potential). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa NEUROD6 HGNC:13804 neuronal differentiation 6 Q96NK8 Nucleus (Probable). Nucleus (GO:0005634) 15036409 nucleus 49 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa NEUROG1 HGNC:7764 neurogenin 1 Q92886 Nucleus (Probable). Nucleus (GO:0005634) 11239394 nucleus 56 0 nucleus nucleus Chordata Bilateria Metazoa NEUROG2 HGNC:13805 neurogenin 2 Q9H2A3 Nucleus (Potential). Nucleus (GO:0005634) 9539123 nucleus 58 0 nucleus nucleus Tetrapoda Tetrapoda Metazoa NEUROG3 HGNC:13806 neurogenin 3 Q9Y4Z2 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Theria Bilateria Metazoa NEXN HGNC:29557 nexilin (F actin binding protein) Q0ZGT2 Cytoplasm, cytoskeleton (By similarity). Cell junction, adherens junction (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9832551,17081983 nucleus 24 0 nucleus nucleus Chordata Chordata Eumetazoa NF1 HGNC:7765 neurofibromin 1 P21359 Cytoplasm (GO:0005737) 10553997 cytoplasm 12 3 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota NF2 HGNC:7773 neurofibromin 2 (merlin) P35240 Isoform 1: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Isoform 7: Cytoplasm, perinuclear region. Cytoplasmic granule. Isoform 9: Cytoplasm, perinuclear region. Cytoplasmic granule. Isoform 10: Nucleus. Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Cytoplasmic granule. Cytoplasm, cytoskeleton. Note=In a fibroblastic cell line, isoform 10 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endosome (GO:0005768); Plasma membrane (GO:0005886);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10401006,10861283,10401006,10861283,10861283,,18332868,/17081983,17081983 cytoplasm 19 0 cytoplasm. endosome. nucleus multiple Deuterostomia Bilateria Eukaryota NFAM1 HGNC:29872 NFAT activating protein with ITAM motif 1 Q8NET5 Cell membrane; Single-pass type I membrane protein (By similarity). Note=Partially recruited to lipid rafts upon BCR stimulation (By similarity). Plasma membrane (GO:0005886) 12615919 plasma membrane 31 3 plasma membrane plasma membrane NA NA Amniota NFASC HGNC:29866 neurofascin O94856 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9804856,8947556,14676309,14614299,11839274,9572267,12223548 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms NFAT5 HGNC:7774 nuclear factor of activated T-cells 5, tonicity-responsive O94916 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10377394,10051678,10051678,11485737 nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa NFATC1 HGNC:7775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 O95644 Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10358178/12469121,16988714,12469121,10358178,16923831,16988714 secreted 17 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa NFATC2 HGNC:7776 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 Q13469 Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7887301,8668213,15688026,7887301,8668213 nucleus 17 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eumetazoa NFATC2IP HGNC:25906 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein Q8NCF5 Nucleus (By similarity). Cytoplasm (By similarity). Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus (By similarity). nucleus 21 0 nucleus nucleus Mammalia Euteleostomi Eukaryota NFATC3 HGNC:7777 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 Q12968 Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7739550,11997392,11997392,7739550 secreted 10 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa NFATC4 HGNC:7778 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Q14934 Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11439183,12787506 secreted 8 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eumetazoa NFE2 HGNC:7780 nuclear factor, erythroid 2 Q16621 Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH. Nucleus (GO:0005634) 8355703 nucleus 38 0 cytoplasm. nucleus multiple Eutheria Tetrapoda Metazoa NFE2L1 HGNC:7781 nuclear factor, erythroid 2-like 1 Q14494 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12729924,12729924 nucleus 29 0 cytoplasm. endoplasmic reticulum membrane. nucleus multiple Chordata Chordata Holozoa NFE2L2 HGNC:7782 nuclear factor, erythroid 2-like 2 Q16236 Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14517290,14517554,14517290,12506115 nucleus 38 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Holozoa NFE2L3 HGNC:7783 nuclear factor, erythroid 2-like 3 Q9Y4A8 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus Eutheria Tetrapoda Holozoa NFE4 HGNC:29902 nuclear factor, erythroid 4 Q86UQ8 Nucleus (Probable). secreted 54 0 nucleus nucleus NA NA NA NFIA HGNC:7784 nuclear factor I/A Q12857 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Human Deuterostomia Metazoa NFIB HGNC:7785 nuclear factor I/B O00712 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Euteleostomi Metazoa NFIC HGNC:7786 nuclear factor I/C (CCAAT-binding transcription factor) P08651 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 3398920/15999204 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Metazoa NFIL3 HGNC:7787 nuclear factor, interleukin 3 regulated Q16649 Nucleus (By similarity). Nucleus (GO:0005634) 7565758,17081983 nucleus 81 0 nucleus nucleus Tetrapoda Bilateria Metazoa NFIX HGNC:7788 nuclear factor I/X (CCAAT-binding transcription factor) Q14938 Nucleus. Nucleus (GO:0005634) 11068044,19059367 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa NFKB1 HGNC:7794 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 P19838 Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12433922,9218802,16319921,17318178,15657065,14678988,8139561,12496256,12433922,16319921,17318178,15657065,16778892,8428580,14678988 nucleus 34 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms NFKB2 HGNC:7795 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Q00653 Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1473734,11980335,10823818,8108136,1473734 nucleus 29 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms NFKBIA HGNC:7797 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha P25963 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export (By similarity). Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10655476,9734360,16319058,12433922,10655476,16319058,17318178,9873017 cytoplasm 64 0 cytoplasm. mitochondrion. nucleus multiple Chordata Bilateria Cell.Organisms NFKBIB HGNC:7798 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Q15653 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9452433,12651903,12651903,9873017 cytoplasm 23 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms NFKBID HGNC:15671 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta Q8NI38 Nucleus (By similarity). nucleus 85 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms NFKBIE HGNC:7799 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon O00221 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12361703,11970947,11970947 cytoplasm 78 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms NFKBIL1 HGNC:7800 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 Q9UBC1 Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia NA NFKBIZ HGNC:29805 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta Q9BYH8 Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2. Nucleus (GO:0005634) 11278262 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms NFRKB HGNC:7802 nuclear factor related to kappaB binding protein Q6P4R8 Nucleus. Nucleus (GO:0005634); Chromosome (GO:0005694) none,17081983,16230350 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota NFS1 HGNC:15910 NFS1 cysteine desulfurase Q9Y697 Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm. Nucleus. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9885568,9885568,9885568 mitochondrion 59 0 cytoplasm. mitochondrion. nucleus multiple NA NA Cell.Organisms NFU1 HGNC:16287 NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) Q9UMS0 Mitochondrion. Cytoplasm, cytosol. Cytosol (GO:0005829); Nucleus (GO:0005634);Mitochondrion (GO:0005739);Mitochondrion (GO:0005739) 12886008,12886008/12886008,11342215/15598749 mitochondrion 47 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms NFX1 HGNC:7803 nuclear transcription factor, X-box binding 1 Q12986 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15358174,15358174,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NFXL1 HGNC:18726 nuclear transcription factor, X-box binding-like 1 Q6ZNB6 Membrane; Single-pass membrane protein (Potential). Cytoplasm (GO:0005737) 17081983 nucleus 23 1 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota NFYA HGNC:7804 nuclear transcription factor Y, alpha P23511 Nucleus. Nucleus (GO:0005634) 11777930,16959611 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota NFYB HGNC:7805 nuclear transcription factor Y, beta P25208 Nucleus. Nucleus (GO:0005634) 8027044,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NFYC HGNC:7806 nuclear transcription factor Y, gamma Q13952 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12023901,7969168,12023901 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NGB HGNC:14077 neuroglobin Q9NPG2 Perikaryon (By similarity). Cytoplasm. Mitochondrion. Cytoplasm (GO:0005737) 12850561 secreted 20 0 cytoplasm. mitochondrion multiple Euteleostomi Cell.Organisms Cell.Organisms NGDN HGNC:20271 neuroguidin, EIF4E binding protein Q8NEJ9 Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, filopodium (By similarity). Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Nucleolus (GO:0005730);Nucleus (GO:0005634) 15635413,11790298/17081983 nucleus 11 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota NGEF HGNC:7807 neuronal guanine nucleotide exchange factor Q8N5V2 Cytoplasm (By similarity). Membrane (By similarity). Cell projection, growth cone (By similarity). Note=Associated with membranes. Localizes to axonal growth cones (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11336673,11336673 cytoplasm 12 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota NGF HGNC:7808 nerve growth factor (beta polypeptide) P01138 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634) 8633048,17081983 secreted 100 0 nucleus. secreted multiple Euteleostomi Euteleostomi Bilateria NGFR HGNC:7809 nerve growth factor receptor P08138 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1324502 secreted 17 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Eukaryota NGFRAP1 HGNC:13388 nerve growth factor receptor (TNFRSF16) associated protein 1 Q00994 Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10764727,10764727 cytoplasm 49 0 cytoplasm. nucleus multiple Eutheria Eutheria Eutheria NGLY1 HGNC:17646 N-glycanase 1 Q96IV0 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota NGRN HGNC:18077 neugrin, neurite outgrowth associated Q9NPE2 Nucleus. Secreted (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11118320,11118320 mitochondrion 25 0 cytoplasm. nucleus multiple Eutheria Deuterostomia Eukaryota NHEJ1 HGNC:25737 nonhomologous end-joining factor 1 Q9H9Q4 Nucleus. Nucleus (GO:0005634) 16439204,16439205 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta NHLH1 HGNC:7817 nescient helix loop helix 1 Q02575 Nucleus (By similarity). Nucleus (GO:0005634) 10603358 nucleus 56 0 nucleus nucleus Tetrapoda Bilateria Bilateria NHLH2 HGNC:7818 nescient helix loop helix 2 Q02577 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Amniota Euteleostomi Bilateria NHLRC1 HGNC:21576 NHL repeat containing E3 ubiquitin protein ligase 1 Q6VVB1 Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12958597,12958597 cytoplasm 13 0 endoplasmic reticulum. nucleus multiple Tetrapoda Cell.Organisms Metazoa NHLRC2 HGNC:24731 NHL repeat containing 2 Q8NBF2 cytoplasm 42 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms NHLRC3 HGNC:33751 NHL repeat containing 3 Q5JS37 Secreted (Potential). Integral to membrane (GO:0016021) cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms NHLRC4 HGNC:26700 NHL repeat containing 4 P0CG21 cytoplasm 32 0 cytoplasm cytoplasm NA NA Cell.Organisms NHP2 HGNC:14377 NHP2 ribonucleoprotein Q9NX24 Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). Nucleus (GO:0005634); Nucleolus (GO:0005730) 11074001,15561729,11074001,11790298,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NHP2L1 HGNC:7819 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) P55769 Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus. Nucleolus (GO:0005730) 10593953,11790298,15635413 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms NHS HGNC:7820 Nance-Horan syndrome (congenital cataracts and dental anomalies) Q6T4R5 Isoform 1: Apical cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Isoform 3: Cytoplasm. Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 cytoplasm 9 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria NHSL1 HGNC:21021 NHS-like 1 Q5SYE7 cytoplasm 27 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Euteleostomi NHSL2 HGNC:33737 NHS-like 2 Q5HYW2 cytoplasm 15 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata NICN1 HGNC:18317 nicolin 1 Q9BSH3 Nucleus. Nucleus (GO:0005634) 12392556 nucleus 100 0 nucleus nucleus Chordata Chordata Metazoa NID1 HGNC:7821 nidogen 1 P14543 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 12180907 secreted 27 0 secreted secreted Bilateria Bilateria Cell.Organisms NID2 HGNC:13389 nidogen 2 (osteonidogen) Q14112 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 9733643 secreted 26 0 secreted secreted Bilateria Bilateria Cell.Organisms NIF3L1 HGNC:13390 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) Q9GZT8 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12522100,11124544,12951069 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms NIFK HGNC:17838 nucleolar protein interacting with the FHA domain of MKI67 Q9BYG3 Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11342549,15635413,11342549,11342549,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms NIM1K HGNC:28646 NIM1 serine/threonine protein kinase Q8IY84 cytoplasm 25 1 cytoplasm cytoplasm NA NA Cell.Organisms NIN HGNC:14906 ninein (GSK3B interacting protein) Q8N4C6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Centrosome (GO:0005813); Plasma membrane (GO:0005886) 11956314,17139249,15561729,17139249 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eumetazoa NINJ1 HGNC:7824 ninjurin 1 Q92982 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8780658 plasma membrane 13 2 plasma membrane plasma membrane Deuterostomia Bilateria Bilateria NINJ2 HGNC:7825 ninjurin 2 Q9NZG7 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10627596,17081983 golgi apparatus membrane 22 2 cytoplasm. plasma membrane multiple Amniota Bilateria Bilateria NINL HGNC:29163 ninein-like Q9Y2I6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein- dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm. Centrosome (GO:0005813) cytoplasm 100 0 cytoplasm cytoplasm Human Euteleostomi Eukaryota NIP7 HGNC:24328 NIP7, nucleolar pre-rRNA processing protein Q9Y221 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 14660641,12429849,15635413,14660641 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NIPA1 HGNC:17043 non imprinted in Prader-Willi/Angelman syndrome 1 Q7RTP0 Cell membrane; Multi-pass membrane protein (Potential). Early endosome (By similarity). Note=Recruited to the cell membrane in response to low extracellular magnesium (By similarity). golgi apparatus membrane 80 9 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eukaryota NIPA2 HGNC:17044 non imprinted in Prader-Willi/Angelman syndrome 2 Q8N8Q9 Cell membrane; Multi-pass membrane protein (Potential). Early endosome (By similarity). Note=Recruited to the cell membrane in response to low extracellular magnesium (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 82 9 golgi apparatus membrane golgi apparatus membrane Bilateria Eukaryota Eukaryota NIPAL1 HGNC:27194 NIPA-like domain containing 1 Q6NVV3 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 84 9 golgi apparatus membrane golgi apparatus membrane Mammalia Tetrapoda Eukaryota NIPAL2 HGNC:25854 NIPA-like domain containing 2 Q9H841 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 15317751 golgi apparatus membrane 77 9 golgi apparatus membrane golgi apparatus membrane Theria Opisthokonta Eukaryota NIPAL3 HGNC:25233 NIPA-like domain containing 3 Q6P499 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 77 9 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eukaryota NIPAL4 HGNC:28018 NIPA-like domain containing 4 Q0D2K0 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 15317751 golgi apparatus membrane 68 10 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota NIPBL HGNC:28862 Nipped-B homolog (Drosophila) Q6KC79 Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) none,17081983,15635413,17081983 nucleus 26 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms NIPSNAP1 HGNC:7827 nipsnap homolog 1 (C. elegans) Q9BPW8 Mitochondrion (GO:0005739) 15598749 cytoplasm 8 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms NIPSNAP3A HGNC:23619 nipsnap homolog 3A (C. elegans) Q9UFN0 Cytoplasm, cytosol. Note=May be part of some vesicular structure distinct from lysosomal vesicles. Plasma membrane (GO:0005886); Cytosol (GO:0005829); Mitochondrion (GO:0005739) 15177564,12427096,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms NIPSNAP3B HGNC:23641 nipsnap homolog 3B (C. elegans) Q9BS92 cytoplasm 84 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms NISCH HGNC:18006 nischarin Q9Y2I1 Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10882231,15028623,15028622,15028622,12868002 plasma membrane 20 0 cytoplasm. endosome multiple Bilateria Eukaryota Cell.Organisms NIT1 HGNC:7828 nitrilase 1 Q86X76 Cytoplasm. Mitochondrion (By similarity). cytoplasm 23 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms NIT2 HGNC:29878 nitrilase family, member 2 Q9NQR4 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms NKAIN1 HGNC:25743 Na+/K+ transporting ATPase interacting 1 Q4KMZ8 Cell membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 29 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Eumetazoa NKAIN2 HGNC:16443 Na+/K+ transporting ATPase interacting 2 Q5VXU1 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11979551 endoplasmic reticulum membrane 29 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Euteleostomi Eumetazoa NKAIN3 HGNC:26829 Na+/K+ transporting ATPase interacting 3 Q8N8D7 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 36 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Chordata Eumetazoa NKAIN4 HGNC:16191 Na+/K+ transporting ATPase interacting 4 Q8IVV8 Cell membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 35 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Chordata Eumetazoa NKAP HGNC:29873 NFKB activating protein Q8N5F7 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14550261,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Human Human Eukaryota NKAPL HGNC:21584 NFKB activating protein-like Q5M9Q1 nucleus 57 0 nucleus nucleus Mammalia Mammalia Eukaryota NKD1 HGNC:17045 naked cuticle homolog 1 (Drosophila) Q969G9 Cell membrane (By similarity). Cytoplasm (By similarity). nucleus 72 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa NKD2 HGNC:17046 naked cuticle homolog 2 (Drosophila) Q969F2 Cell membrane. Cytoplasm. Cytoplasmic vesicle. nucleus 65 0 cytoplasm cytoplasm Human Human Holozoa NKG7 HGNC:7830 natural killer cell granule protein 7 Q16617 Cell membrane; Multi-pass membrane protein. Cytoplasmic granule membrane; Multi-pass membrane protein. Note=Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils. Integral to membrane (GO:0016021) 8458737 plasma membrane 28 4 plasma membrane plasma membrane Eutheria Eutheria Amniota NKIRAS1 HGNC:17899 NFKB inhibitor interacting Ras-like 1 Q9NYS0 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Theria Bilateria Eukaryota NKIRAS2 HGNC:17898 NFKB inhibitor interacting Ras-like 2 Q9NYR9 Cytoplasm (By similarity). cytoplasm 65 0 cytoplasm cytoplasm Euteleostomi Deuterostomia NA NKPD1 HGNC:24739 NTPase, KAP family P-loop domain containing 1 Q17RQ9 Membrane; Multi-pass membrane protein (Potential). nucleus 56 3 nucleus nucleus Mammalia Euteleostomi Cell.Organisms NKRF HGNC:19374 NFKB repressing factor O15226 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10562553,17081983,15635413 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota NKTR HGNC:7833 natural killer cell triggering receptor P30414 Membrane; Peripheral membrane protein. Note=Attached to the membrane via its N-terminus. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8421688,17081983,17081983 mitochondrion 47 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms NKX1-1 HGNC:24975 NK1 homeobox 1 Q15270 Nucleus (By similarity). nucleus 42 0 nucleus nucleus NA NA Eukaryota NKX1-2 HGNC:31652 NK1 homeobox 2 Q9UD57 Nucleus (By similarity). nucleus 42 0 nucleus nucleus NA NA Eukaryota NKX2-1 HGNC:11825 NK2 homeobox 1 P43699 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9396717,7713914,11953175 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota NKX2-2 HGNC:7835 NK2 homeobox 2 O95096 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10772886,10772886 nucleus 98 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa NKX2-3 HGNC:7836 NK2 homeobox 3 Q8TAU0 Nucleus (By similarity). Nucleus (GO:0005634) 11457859 nucleus 33 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa NKX2-4 HGNC:7837 NK2 homeobox 4 Q9H2Z4 Nucleus (By similarity). nucleus 54 0 nucleus nucleus Theria Euteleostomi Metazoa NKX2-5 HGNC:2488 NK2 homeobox 5 P52952 Nucleus (Probable). Nucleus (GO:0005634) 10903346 nucleus 33 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa NKX2-6 HGNC:32940 NK2 homeobox 6 A6NCS4 Nucleus (Probable). nucleus 33 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota NKX2-8 HGNC:16364 NK2 homeobox 8 O15522 Nucleus (Probable). Nucleus (GO:0005634) 12167706 nucleus 36 0 nucleus nucleus Theria Euteleostomi Opisthokonta NKX3-1 HGNC:7838 NK3 homeobox 1 Q99801 Nucleus. Nucleus (GO:0005634) 11085535 nucleus 100 0 nucleus nucleus Mammalia Tetrapoda Eukaryota NKX3-2 HGNC:951 NK3 homeobox 2 P78367 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Theria Euteleostomi Eukaryota NKX6-1 HGNC:7839 NK6 homeobox 1 P78426 Nucleus (Probable). Nucleus (GO:0005634) nucleus 96 0 nucleus nucleus Mammalia Bilateria Eukaryota NKX6-2 HGNC:19321 NK6 homeobox 2 Q9C056 Nucleus (Probable). Nucleus (GO:0005634) nucleus 63 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota NKX6-3 HGNC:26328 NK6 homeobox 3 A6NJ46 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Human Tetrapoda Eukaryota NLE1 HGNC:19889 notchless homolog 1 (Drosophila) Q9NVX2 Nucleus, nucleolus. Nucleolus (GO:0005730) 15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NLGN1 HGNC:14291 neuroligin 1 Q8N2Q7 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). Plasma membrane (GO:0005886) 7736595 secreted 22 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms NLGN2 HGNC:14290 neuroligin 2 Q8NFZ4 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). Plasma membrane (GO:0005886) 10996085,8576240 endoplasmic reticulum 23 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms NLGN3 HGNC:14289 neuroligin 3 Q9NZ94 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Note=Detected at both glutamatergic and GABAergic synapses (By similarity). Plasma membrane (GO:0005886) 11329178 endoplasmic reticulum 23 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms NLGN4X HGNC:14287 neuroligin 4, X-linked Q8N0W4 Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Plasma membrane (GO:0005886) 11368788 secreted 22 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms NLGN4Y HGNC:15529 neuroligin 4, Y-linked Q8NFZ3 Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). secreted 22 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms NLK HGNC:29858 nemo-like kinase Q9UBE8 Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15082531,9448268,9448268 nucleus 27 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms NLN HGNC:16058 neurolysin (metallopeptidase M3 family) Q9BYT8 Mitochondrion intermembrane space (By similarity). Cytoplasm (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 9735321,9003076,9257187,9257187,9735321,15598749,9257187 cytoplasm 56 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms NLRC3 HGNC:29889 NLR family, CARD domain containing 3 Q7RTR2 Cytoplasm. Cytoplasm (GO:0005737) 15705585 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms NLRC4 HGNC:16412 NLR family, CARD domain containing 4 Q9NPP4 Cytoplasm. Cytoplasm, cytosol (By similarity). Note=Cytoplasmic filaments. Cytoplasm (GO:0005737) 11390368 cytoplasm 100 0 cytoplasm cytoplasm Human Tetrapoda Holozoa NLRC5 HGNC:29933 NLR family, CARD domain containing 5 Q86WI3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms NLRP1 HGNC:14374 NLR family, pyrin domain containing 1 Q9C000 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Membrane fraction (GO:0005624) 17418785,11076957,17418785,11076957 cytoplasm 28 2 cytoplasm. nucleus multiple Eutheria Tetrapoda Cell.Organisms NLRP10 HGNC:21464 NLR family, pyrin domain containing 10 Q86W26 Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. cytoplasm 23 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa NLRP11 HGNC:22945 NLR family, pyrin domain containing 11 P59045 Cytoplasm (GO:0005737) 12387869 cytoplasm 14 0 cytoplasm cytoplasm Catarrhini Catarrhini Cell.Organisms NLRP12 HGNC:22938 NLR family, pyrin domain containing 12 P59046 Cytoplasm. Cytoplasm (GO:0005737) 12019269 cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NLRP13 HGNC:22937 NLR family, pyrin domain containing 13 Q86W25 cytoplasm 19 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NLRP14 HGNC:22939 NLR family, pyrin domain containing 14 Q86W24 Cytoplasm (GO:0005737) 12563287 cytoplasm 26 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NLRP2 HGNC:22948 NLR family, pyrin domain containing 2 Q9NX02 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12387869,17178784,17178784 cytoplasm 100 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria NA NLRP3 HGNC:16400 NLR family, pyrin domain containing 3 Q96P20 Cytoplasm. Cytoplasm (GO:0005737) 11786556 cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NLRP4 HGNC:22943 NLR family, pyrin domain containing 4 Q96MN2 cytoplasm 21 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NLRP5 HGNC:21269 NLR family, pyrin domain containing 5 P59047 Mitochondrion (By similarity). Nucleus, nucleolus (By similarity). Cytoplasm (By similarity). Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12563287,11925379,11925379 cytoplasm 17 0 cytoplasm. nucleus multiple Amniota Eukaryota Cell.Organisms NLRP6 HGNC:22944 NLR family, pyrin domain containing 6 P59044 Cytoplasm. Cell membrane (By similarity). Nucleus membrane (By similarity). Cytoplasm (GO:0005737) 12633874 cytoplasm 20 2 cytoplasm cytoplasm Eutheria Eutheria Metazoa NLRP7 HGNC:22947 NLR family, pyrin domain containing 7 Q8WX94 Cytoplasm (GO:0005737) 12387869 cytoplasm 54 0 cytoplasm cytoplasm Euarchontoglires Eutheria NA NLRP8 HGNC:22940 NLR family, pyrin domain containing 8 Q86W28 Cytoplasm (By similarity). cytoplasm 18 0 cytoplasm cytoplasm Catarrhini Eutheria Cell.Organisms NLRP9 HGNC:22941 NLR family, pyrin domain containing 9 Q7RTR0 Cytoplasm (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NLRX1 HGNC:29890 NLR family member X1 Q86UT6 Mitochondrion outer membrane. cytoplasm 9 2 cytoplasm cytoplasm Mammalia Euteleostomi Opisthokonta NMB HGNC:7842 neuromedin B P08949 Secreted. Extracellular (GO:0005576) 1717141 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi NMBR HGNC:7843 neuromedin B receptor P28336 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Eumetazoa NMD3 HGNC:24250 NMD3 ribosome export adaptor Q96D46 Cytoplasm. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner. Nucleolus (GO:0005730) 15635413 nucleus 71 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NME1 HGNC:7849 NME/NM23 nucleoside diphosphate kinase 1 P15531 Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576); Mitochondrion (GO:0005739) 2509941,2509941,12135660,15598749 cytoplasm 72 0 cytoplasm. mitochondrion. nucleus. secreted multiple NA NA Cell.Organisms NME2 HGNC:7850 NME/NM23 nucleoside diphosphate kinase 2 P22392 Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874); Intermediate filament (GO:0005882); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 2509941,9925751,9925751,2509941,9925751,11082283,14976202,15598749 cytoplasm 72 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NME3 HGNC:7851 NME/NM23 nucleoside diphosphate kinase 3 Q13232 Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11042679,11042679 cytoplasm 57 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms NME4 HGNC:7852 NME/NM23 nucleoside diphosphate kinase 4 O00746 Mitochondrion intermembrane space. Mitochondrion (GO:0005739) 10799505 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms NME5 HGNC:7853 NME/NM23 family member 5 P56597 Cytoplasm (GO:0005737) 14499630 cytoplasm 26 1 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NME6 HGNC:20567 NME/NM23 nucleoside diphosphate kinase 6 O75414 Mitochondrion (GO:0005739) 10618642 cytoplasm 22 0 mitochondrion mitochondrion Deuterostomia Eukaryota Cell.Organisms NME7 HGNC:20461 NME/NM23 family member 7 Q9Y5B8 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NME8 HGNC:16473 NME/NM23 family member 8 Q8N427 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11737268,11737268,11737268 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms NME9 HGNC:21343 NME/NM23 family member 9 Q86XW9 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity). Cytoskeleton (GO:0005856) 14713334,12569107 cytoplasm 26 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms NMI HGNC:7854 N-myc (and STAT) interactor Q13287 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10950963,10597290,16214168,10574616,10597290,16214168 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata NMNAT1 HGNC:17877 nicotinamide nucleotide adenylyltransferase 1 Q9HAN9 Nucleus. Nucleus (GO:0005634) 11248244,11751893 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NMNAT2 HGNC:16789 nicotinamide nucleotide adenylyltransferase 2 Q9BZQ4 Cytoplasm. Golgi apparatus. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 12359228,16118205,14516279,16118205 mitochondrion 32 0 cytoplasm. golgi apparatus multiple Chordata Chordata Eukaryota NMNAT3 HGNC:20989 nicotinamide nucleotide adenylyltransferase 3 Q96T66 Mitochondrion. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12574164,12574164 mitochondrion 100 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms NMRAL1 HGNC:24987 NmrA-like family domain containing 1 Q9HBL8 Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios. cytoplasm 54 0 cytoplasm. nucleus multiple Tetrapoda Cell.Organisms Cell.Organisms NMRK1 HGNC:26057 nicotinamide riboside kinase 1 Q9NWW6 cytoplasm 39 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms NMRK2 HGNC:17871 nicotinamide riboside kinase 2 Q9NPI5 Cytoplasm (GO:0005737) cytoplasm 49 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms NMS HGNC:32203 neuromedin S Q5H8A3 Secreted (By similarity). secreted 40 0 secreted secreted Eutheria Eutheria Euteleostomi NMT1 HGNC:7857 N-myristoyltransferase 1 P30419 Cytoplasm. Ribosome (GO:0005840); Nucleus (GO:0005634) 9353336,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NMT2 HGNC:7858 N-myristoyltransferase 2 O60551 Cytoplasm. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 9506952,9506952 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota NMU HGNC:7859 neuromedin U P48645 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Tetrapoda Euteleostomi Euteleostomi NMUR1 HGNC:4518 neuromedin U receptor 1 Q9HB89 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa NMUR2 HGNC:16454 neuromedin U receptor 2 Q9GZQ4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 10899166 plasma membrane 100 7 plasma membrane plasma membrane Bilateria Bilateria Eumetazoa NNAT HGNC:7860 neuronatin Q16517 Integral to membrane (GO:0016021) 8813377 secreted 42 1 secreted secreted Eutheria Eutheria Eutheria NNMT HGNC:7861 nicotinamide N-methyltransferase P40261 Cytoplasm. Cytoplasm (GO:0005737) 8575745,9804963,8845860 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Bilateria Metazoa NNT HGNC:7863 nicotinamide nucleotide transhydrogenase Q13423 Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side (Potential). Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 9524818,12223207,10673423,15598749 plasma membrane 24 15 mitochondrion. mitochondrion membrane multiple Bilateria Cell.Organisms Cell.Organisms NOA1 HGNC:28473 nitric oxide associated 1 Q8NC60 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. nucleus 20 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms NOB1 HGNC:29540 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) Q9ULX3 Nucleus. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NOBOX HGNC:22448 NOBOX oogenesis homeobox O60393 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15326356,15326356 nucleus 47 0 cytoplasm. nucleus multiple Amniota Amniota Eukaryota NOC2L HGNC:24517 nucleolar complex associated 2 homolog (S. cerevisiae) Q9Y3T9 Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin- D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11790298,17081983,17081983 nucleus 100 5 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NOC3L HGNC:24034 nucleolar complex associated 3 homolog (S. cerevisiae) Q8WTT2 Nucleus, nucleolus. Nucleus speckle. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NOC4L HGNC:28461 nucleolar complex associated 4 homolog (S. cerevisiae) Q9BVI4 Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus. nucleus 19 3 nucleus. nucleus membrane multiple Eukaryota Eukaryota Eukaryota NOD1 HGNC:16390 nucleotide-binding oligomerization domain containing 1 Q9Y239 Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells. Cytoplasm (GO:0005737) 11058605 cytoplasm 20 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms NOD2 HGNC:5331 nucleotide-binding oligomerization domain containing 2 Q9HC29 Cytoplasm. Cytoplasm (GO:0005737) 11834373 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms NODAL HGNC:7865 nodal growth differentiation factor Q96S42 Secreted (By similarity). Extracellular (GO:0005576) 12052855 secreted 20 0 secreted secreted Theria Euteleostomi Metazoa NOG HGNC:7866 noggin Q13253 Secreted. Extracellular (GO:0005576) 11562478 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Eumetazoa NOL10 HGNC:25862 nucleolar protein 10 Q9BSC4 Nucleus, nucleolus. Nucleolus (GO:0005730) 11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NOL11 HGNC:24557 nucleolar protein 11 Q9H8H0 Nucleus, nucleolus. Nucleolus (GO:0005730) 12429849 nucleus 100 1 nucleus nucleus Deuterostomia Deuterostomia Eumetazoa NOL12 HGNC:28585 nucleolar protein 12 Q9UGY1 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 17081983 nucleus 86 0 nucleus nucleus Euteleostomi Bilateria NA NOL3 HGNC:7869 nucleolar protein 3 (apoptosis repressor with CARD domain) O60936 Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10196175,10196175,10196175,12191471 nucleus 78 0 cytoplasm. mitochondrion. nucleus multiple Mammalia Mammalia Mammalia NOL4 HGNC:7870 nucleolar protein 4 O94818 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 9813152,9813152 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta NOL6 HGNC:19910 nucleolar protein 6 (RNA-associated) Q9H6R4 Nucleus, nucleolus. Chromosome (By similarity). Note=Localizes to condensed chromosomes in mitosis (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,11790298,15561729 nucleus 100 1 nucleus nucleus Eukaryota Eukaryota Eukaryota NOL7 HGNC:21040 nucleolar protein 7, 27kDa Q9UMY1 Nucleus, nucleolus. Nucleolus (GO:0005730) 11790298,15635413 nucleus 100 0 nucleus nucleus NA NA Euteleostomi NOL8 HGNC:23387 nucleolar protein 8 Q76FK4 Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15132771,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms NOL9 HGNC:26265 nucleolar protein 9 Q5SY16 Nucleus (By similarity). Nucleus, nucleolus. Note=Colocalizes with pre-60S rRNP particles. Nucleolus (GO:0005730) 11790298,12429849 nucleus 11 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms NOLC1 HGNC:15608 nucleolar and coiled-body phosphoprotein 1 Q14978 Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10567578,15635413,11790298,9679133,7657714 nucleus 50 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota NOM1 HGNC:13244 nucleolar protein with MIF4G domain 1 Q5C9Z4 Nucleus, nucleolus. Nucleolus (GO:0005730) 15715967 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NOMO1 HGNC:30060 NODAL modulator 1 Q15155 Membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 15257293,15598749 endoplasmic reticulum membrane 99 1 endoplasmic reticulum. mitochondrion multiple Bilateria Eukaryota Cell.Organisms NOMO2 HGNC:22652 NODAL modulator 2 Q5JPE7 Endoplasmic reticulum membrane; Single-pass membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota NOMO3 HGNC:25242 NODAL modulator 3 P69849 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 15257293 endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota NONO HGNC:7871 non-POU domain containing, octamer-binding Q15233 Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 8371983,12403470,17081983,12810069,15635413,11790298,15598749 nucleus 100 0 mitochondrion. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms NOP10 HGNC:14378 NOP10 ribonucleoprotein Q9NPE3 Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). Nucleus (GO:0005634); Nucleolus (GO:0005730) 11074001,11074001,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NOP14 HGNC:16821 NOP14 nucleolar protein P78316 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634); Nucleus (GO:0005634) 15561729,17081983 nucleus 12 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota NOP16 HGNC:26934 NOP16 nucleolar protein Q9Y3C1 Nucleus, nucleolus. Nucleolus (GO:0005730) 11790298 nucleus 100 0 nucleus nucleus Bilateria Bilateria Holozoa NOP2 HGNC:7867 NOP2 nucleolar protein P46087 Nucleus, nucleolus. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8089149,3422591,2576976,8089149,17081983 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NOP56 HGNC:15911 NOP56 ribonucleoprotein O00567 Nucleus, nucleolus. Cytoplasm (By similarity). Nucleolus (GO:0005730); Ribosome (GO:0005840) 9372940,15635413,11790298,15561729 nucleus 46 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms NOP58 HGNC:29926 NOP58 ribonucleoprotein Q9Y2X3 Nucleus, nucleolus. Nucleolus (GO:0005730); Ribosome (GO:0005840) 10606270,12032086,12417735,15635413,15561729 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms NOP9 HGNC:19826 NOP9 nucleolar protein Q86U38 Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 15635413,17081983 nucleus 8 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota NOS1 HGNC:7872 nitric oxide synthase 1 (neuronal) P29475 Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). Plasma membrane (GO:0005886); Cytosol (GO:0005829) 7545544,9880522 nucleus 23 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms NOS1AP HGNC:16859 nitric oxide synthase 1 (neuronal) adaptor protein O75052 Cytoplasm (GO:0005737) 9459447 cytoplasm 15 0 cytoplasm cytoplasm Chordata Bilateria Metazoa NOS2 HGNC:7873 nitric oxide synthase 2, inducible P35228 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10842192,12080081,11114180,12080081 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms NOS3 HGNC:7876 nitric oxide synthase 3 (endothelial cell) P29474 Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. Perinuclear region (GO:0048471); Plasma membrane (GO:0005886); Golgi membrane (GO:0000139); Cytosol (GO:0005829) 11729179,11729179,11729179,11729179 cytoplasm 17 0 cytoplasm. golgi apparatus. golgi apparatus membrane multiple Deuterostomia Cell.Organisms Cell.Organisms NOSIP HGNC:17946 nitric oxide synthase interacting protein Q9Y314 Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. Cytoplasmic vesicle (GO:0016023); Nucleolus (GO:0005730) 11149895,15635413 nucleus 58 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota NOSTRIN HGNC:20203 nitric oxide synthase trafficking Q8IVI9 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 12446846,12446846,12446846 cytoplasm 28 0 cytoplasm. golgi apparatus multiple Mammalia Bilateria NA NOTCH1 HGNC:7881 notch 1 P46531 Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity). Note=Following proteolytical processing NICD is translocated to the nucleus (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytosol (GO:0005829) 9244302,9653148,9111040,10206645,16319921,16319921 plasma membrane 25 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms NOTCH2 HGNC:7882 notch 2 Q04721 Cell membrane; Single-pass type I membrane protein. Notch 2 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 9244302,9244302,9244302,10958687 plasma membrane 27 1 endoplasmic reticulum. golgi apparatus. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms NOTCH2NL HGNC:31862 notch 2 N-terminal like Q7Z3S9 Secreted. Cytoplasm. Extracellular (GO:0005576) 14673143 plasma membrane 31 0 cytoplasm. secreted multiple Human Human Eukaryota NOTCH3 HGNC:7883 notch 3 Q9UM47 Cell membrane; Single-pass type I membrane protein. Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 7835890,10712431,10712431,12482954,11404076 plasma membrane 27 1 endoplasmic reticulum. golgi apparatus. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms NOTCH4 HGNC:7884 notch 4 Q99466 Cell membrane; Single-pass type I membrane protein. Notch 4 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 8681805,11119607,11119607 secreted 25 1 endoplasmic reticulum. nucleus. plasma membrane multiple Bilateria Bilateria NA NOTO HGNC:31839 notochord homeobox A8MTQ0 Nucleus (By similarity). nucleus 35 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota NOTUM HGNC:27106 notum pectinacetylesterase homolog (Drosophila) Q6P988 Secreted (By similarity). secreted 91 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms NOV HGNC:7885 nephroblastoma overexpressed P48745 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634) 10084601,10474687 secreted 100 0 nucleus. secreted multiple Tetrapoda Bilateria Bilateria NOVA1 HGNC:7886 neuro-oncological ventral antigen 1 P51513 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8558240,9154818,16041372,12808107,8558240 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota NOVA2 HGNC:7887 neuro-oncological ventral antigen 2 Q9UNW9 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 73 0 nucleus nucleus Bilateria Eukaryota Eukaryota NOX1 HGNC:7889 NADPH oxidase 1 Q9Y5S8 Cell projection, invadopodium membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Cytoplasm (GO:0005737); Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12955083,10974555,14670934,14617635,12955083,12955083/12955083,12955083 plasma membrane 50 8 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms NOX3 HGNC:7890 NADPH oxidase 3 Q9HBY0 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10974555 plasma membrane 49 8 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms NOX4 HGNC:7891 NADPH oxidase 4 Q9NPH5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (Probable). Cell junction, focal adhesion (Probable). Nucleus (Probable). Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 14670934,14670934 plasma membrane 28 8 endoplasmic reticulum membrane. nucleus. plasma membrane multiple Chordata Opisthokonta Cell.Organisms NOX5 HGNC:14874 NADPH oxidase, EF-hand calcium binding domain 5 Q96PH1 Membrane; Multi-pass membrane protein (Potential). Isoform v2: Endoplasmic reticulum. Isoform v5: Endoplasmic reticulum. plasma membrane 21 7 endoplasmic reticulum endoplasmic reticulum NA NA Eukaryota NOXA1 HGNC:10668 NADPH oxidase activator 1 Q86UR1 Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1. cytoplasm 28 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms NOXO1 HGNC:19404 NADPH oxidase organizer 1 Q8NFA2 Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner. Plasma membrane (GO:0005886) 14617635,15181005 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta NOXRED1 HGNC:20487 NADP-dependent oxidoreductase domain containing 1 Q6NXP6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms NPAP1 HGNC:1190 nuclear pore associated protein 1 Q9NZP6 Nucleus, nucleoplasm. Nucleus inner membrane. Note=Colocalizes with the NPC and nuclear lamins at the nuclear periphery. plasma membrane 10 0 nucleus nucleus Catarrhini Eutheria Eutheria NPAS1 HGNC:7894 neuronal PAS domain protein 1 Q99742 Nucleus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) 9012850,9012850 nucleus 84 0 nucleus nucleus Mammalia Deuterostomia Cell.Organisms NPAS2 HGNC:7895 neuronal PAS domain protein 2 Q99743 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 86 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms NPAS3 HGNC:19311 neuronal PAS domain protein 3 Q8IXF0 Nucleus. Nucleus (GO:0005634) 12746393 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms NPAS4 HGNC:18983 neuronal PAS domain protein 4 Q8IUM7 Nucleus. nucleus 100 0 nucleus nucleus Theria Bilateria Metazoa NPAT HGNC:7896 nuclear protein, ataxia-telangiectasia locus Q14207 Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases. Nucleus (GO:0005634) 10995386,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria NPB HGNC:30099 neuropeptide B Q8NG41 Secreted. secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi NPBWR1 HGNC:4522 neuropeptides B/W receptor 1 P48145 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa NPBWR2 HGNC:4530 neuropeptides B/W receptor 2 P48146 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa NPC1 HGNC:7897 Niemann-Pick disease, type C1 O15118 Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764); Plasma membrane (GO:0005886) 9990080,9990080,9990080,9990080 plasma membrane 26 13 cytoplasm. endoplasmic reticulum. endosome membrane. lysosome. lysosome membrane. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms NPC1L1 HGNC:7898 NPC1-like 1 Q9UHC9 Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. Plasma membrane (GO:0005886) 14976318 plasma membrane 73 13 plasma membrane plasma membrane Eukaryota Eukaryota Eukaryota NPC2 HGNC:14537 Niemann-Pick disease, type C2 P61916 Secreted. Endoplasmic reticulum. Lysosome. Cytoplasm (GO:0005737); Lysosome (GO:0005764) 10479477,11125141 secreted 16 0 cytoplasm. endoplasmic reticulum. lysosome. secreted multiple Deuterostomia Bilateria Eumetazoa NPDC1 HGNC:7899 neural proliferation, differentiation and control, 1 Q9NQX5 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) 11245976 secreted 70 1 nucleus nucleus Theria Bilateria Eumetazoa NPEPL1 HGNC:16244 aminopeptidase-like 1 Q8NDH3 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms NPEPPS HGNC:7900 aminopeptidase puromycin sensitive P55786 Cytoplasm, cytosol. Nucleus (Potential). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Endosome (GO:0005768) 9048733,10037494,7592939,10582526,10582526 secreted 19 1 cytoplasm. endosome. golgi apparatus. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms NPFF HGNC:7901 neuropeptide FF-amide peptide precursor O15130 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9224703,8804117,12149260 secreted 100 0 secreted secreted Euarchontoglires Euteleostomi Euteleostomi NPFFR1 HGNC:17425 neuropeptide FF receptor 1 Q9GZQ6 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa NPFFR2 HGNC:4525 neuropeptide FF receptor 2 Q9Y5X5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Plasma membrane (GO:0005886) 10079187,11024015 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa NPHP1 HGNC:7905 nephronophthisis 1 (juvenile) O15259 Cell junction, adherens junction (By similarity). Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction. Note=Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (By similarity). Localized to respiratory cilia axoneme. Localized to the transition zone of respiratory cilia, photoreceptor-connecting cilia and renal monocilia. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10739664,11493697,11493697 cytoplasm 29 4 cytoplasm. plasma membrane multiple Tetrapoda Bilateria Eukaryota NPHP3 HGNC:7907 nephronophthisis 3 (adolescent) Q7Z494 Cell projection, cilium. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus. nucleus 16 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms NPHP4 HGNC:19104 nephronophthisis 4 O75161 Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, tight junction. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. nucleus 28 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota NPHS1 HGNC:7908 nephrosis 1, congenital, Finnish type (nephrin) O60500 Cell membrane; Single-pass type I membrane protein (Potential). Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 11961028,11961028,12853730 plasma membrane 8 1 endoplasmic reticulum. plasma membrane. secreted multiple Bilateria Bilateria Metazoa NPHS2 HGNC:13394 nephrosis 2, idiopathic, steroid-resistant (podocin) Q9NP85 Isoform 1: Cell membrane; Peripheral membrane protein (Potential). Isoform 2: Endoplasmic reticulum. Plasma membrane (GO:0005886) 10742096 plasma membrane 33 1 endoplasmic reticulum. plasma membrane multiple Amniota Euteleostomi Cell.Organisms NPIPA1 HGNC:7909 nuclear pore complex interacting protein family, member A1 Q9UND3 Nucleus, nuclear pore complex. Nucleus membrane. Note=Colocalizes with nuclear pore complex protein NUP62. Nucleus (GO:0005634) 11586358 nucleus 36 1 nucleus nucleus NA NA Primates NPIPA2 HGNC:41979 nuclear pore complex interacting protein family, member A2 E9PIF3 mitochondrion 63 2 mitochondrion mitochondrion NA NA Amniota NPIPA3 HGNC:41978 nuclear pore complex interacting protein family, member A3 F8WFD2 nucleus 47 2 nucleus nucleus NA NA Amniota NPIPA5 HGNC:41980 nuclear pore complex interacting protein family, member A5 E9PKD4 nucleus 61 2 nucleus nucleus NA NA Amniota NPIPA7 HGNC:41982 nuclear pore complex interacting protein family, member A7 E9PJI5 nucleus 31 1 nucleus nucleus NA NA Primates NPIPA8 HGNC:41983 nuclear pore complex interacting protein family, member A8 P0DM63 nucleus 31 2 nucleus nucleus NA NA Primates NPIPB11 HGNC:37453 nuclear pore complex interacting protein family, member B11 E5RHQ5 mitochondrion 63 1 mitochondrion mitochondrion NA NA Eumetazoa NPIPB15 HGNC:34409 nuclear pore complex interacting protein family, member B15 A6NHN6 Secreted (Potential). nucleus 53 2 nucleus nucleus NA NA Primates NPIPB3 HGNC:28989 nuclear pore complex interacting protein family, member B3 Q92617 Membrane; Single-pass membrane protein (Potential). mitochondrion 63 1 mitochondrion mitochondrion Catarrhini Eukaryota Eumetazoa NPIPB4 HGNC:41985 nuclear pore complex interacting protein family, member B4 C9JG80 mitochondrion 63 1 mitochondrion mitochondrion NA NA Eumetazoa NPIPB5 HGNC:37233 nuclear pore complex interacting protein family, member B5 A8MRT5 Membrane; Single-pass membrane protein (Potential). mitochondrion 63 1 mitochondrion mitochondrion NA NA Eumetazoa NPIPB6 HGNC:37454 nuclear pore complex interacting protein family, member B6 E9PJ23 mitochondrion 63 2 mitochondrion mitochondrion NA NA Amniota NPIPB8 HGNC:37490 nuclear pore complex interacting protein family, member B8 E9PQR5 mitochondrion 63 1 mitochondrion mitochondrion NA NA Amniota NPIPB9 HGNC:41987 nuclear pore complex interacting protein family, member B9 F8W1W9 nucleus 48 1 nucleus nucleus NA NA Primates NPL HGNC:16781 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) Q9BXD5 Cytoplasm (By similarity). cytoplasm 91 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms NPLOC4 HGNC:18261 nuclear protein localization 4 homolog (S. cerevisiae) Q8TAT6 Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity). Note=Associated with the endoplasmic reticulum and nuclear (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10811609,12644454,10811609 cytoplasm 19 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NPM1 HGNC:7910 nucleophosmin (nucleolar phosphoprotein B23, numatrin) P06748 Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 17081983,17081983/11051553,15561729,12058066,,12450141,12058066,11790298,15635413,15184379,18259216,,15184379,19059367 nucleus 40 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa NPM2 HGNC:7930 nucleophosmin/nucleoplasmin 2 Q86SE8 Nucleus (By similarity). Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12714744,12714744 nucleus 58 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eumetazoa NPM3 HGNC:7931 nucleophosmin/nucleoplasmin 3 O75607 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11722795,9177783,9177783,17081983,11790298,15635413 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa NPNT HGNC:27405 nephronectin Q6UXI9 Secreted, extracellular space, extracellular matrix (By similarity). Note=Trapped on the cell surface or in the extracellular matrix (By similarity). Extracellular matrix (GO:0005578) 11470831 secreted 85 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms NPPA HGNC:7939 natriuretic peptide A P01160 Secreted. Extracellular (GO:0005576) 10880574,14523183 secreted 100 0 secreted secreted Amniota Euteleostomi Euteleostomi NPPB HGNC:7940 natriuretic peptide B P16860 Secreted. Extracellular (GO:0005576) 12084525 secreted 100 0 secreted secreted Catarrhini Catarrhini Euteleostomi NPPC HGNC:7941 natriuretic peptide C P23582 Secreted. Extracellular (GO:0005576) 12379507 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata NPR1 HGNC:7943 natriuretic peptide receptor 1 P16066 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11952097,,7857923 cytoplasm 33 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms NPR2 HGNC:7944 natriuretic peptide receptor 2 P20594 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12022755,12709393 cytoplasm 30 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms NPR3 HGNC:7945 natriuretic peptide receptor 3 P17342 Membrane; Single-pass type I membrane protein. Nucleus (GO:0005634);Plasma membrane (GO:0005886) 17081983/7996793 plasma membrane 55 1 nucleus. plasma membrane multiple Chordata Chordata Opisthokonta NPRL2 HGNC:24969 nitrogen permease regulator-like 2 (S. cerevisiae) Q8WTW4 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11085536,11085536 nucleus 23 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NPRL3 HGNC:14124 nitrogen permease regulator-like 3 (S. cerevisiae) Q12980 nucleus 30 0 nucleus nucleus Bilateria Eukaryota Eukaryota NPS HGNC:33940 neuropeptide S P0C0P6 Secreted. Nucleus (GO:0005634) 15312648 secreted 100 0 nucleus. secreted multiple Catarrhini Eutheria Amniota NPSR1 HGNC:23631 neuropeptide S receptor 1 Q6W5P4 Isoform 1: Cell membrane; Multi-pass membrane protein. Isoform 3: Cell membrane; Multi-pass membrane protein. Isoform 4: Cell membrane; Multi-pass membrane protein. Isoform 2: Cytoplasm. Isoform 5: Cytoplasm. Isoform 6: Cytoplasm. Isoform 7: Cytoplasm. Isoform 9: Cytoplasm. Plasma membrane (GO:0005886) 15073379,14757815 plasma membrane 22 7 cytoplasm. plasma membrane multiple Amniota Bilateria Eumetazoa NPTN HGNC:17867 neuroplastin Q9Y639 Cell membrane; Single-pass type I membrane protein (Potential). Note=Enriched at postsynaptic density (By similarity). Plasma membrane (GO:0005886) 8995369 secreted 16 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa NPTX1 HGNC:7952 neuronal pentraxin I Q15818 Cytoplasmic vesicle, secretory vesicle (Potential). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10748068,10748068 secreted 48 0 secreted secreted Theria Euteleostomi Cell.Organisms NPTX2 HGNC:7953 neuronal pentraxin II P47972 Secreted (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10748068,10748068 secreted 94 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms NPTXR HGNC:7954 neuronal pentraxin receptor O95502 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 10748068 secreted 40 0 secreted secreted NA NA Cell.Organisms NPVF HGNC:13782 neuropeptide VF precursor Q9HCQ7 Secreted. secreted 100 0 secreted secreted Theria Amniota Tetrapoda NPW HGNC:30509 neuropeptide W Q8N729 Secreted. secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Euteleostomi NPY HGNC:7955 neuropeptide Y P01303 Secreted. Extracellular (GO:0005576) 12479530 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata NPY1R HGNC:7956 neuropeptide Y receptor Y1 P25929 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11741903 plasma membrane 100 7 plasma membrane plasma membrane Chordata Bilateria Metazoa NPY2R HGNC:7957 neuropeptide Y receptor Y2 P49146 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7559383 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa NPY4R HGNC:9329 neuropeptide Y receptor Y4 P50391 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11975932 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa NPY5R HGNC:7958 neuropeptide Y receptor Y5 Q15761 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8824284 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Metazoa NQO1 HGNC:2874 NAD(P)H dehydrogenase, quinone 1 P15559 Cytoplasm. Mitochondrion (GO:0005739); Microsome (GO:0005792); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10487530,10487530,12171070,11888914,2843525,11888914 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms NQO2 HGNC:7856 NAD(P)H dehydrogenase, quinone 2 P16083 Cytoplasm. Cytoplasm (GO:0005737) 8182056,11809856 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms NR0B1 HGNC:7960 nuclear receptor subfamily 0, group B, member 1 P51843 Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7990953,10848616,10848616 nucleus 11 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa NR0B2 HGNC:7961 nuclear receptor subfamily 0, group B, member 2 Q15466 Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11136233,14963109,11890664 nucleus 13 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa NR1D1 HGNC:7962 nuclear receptor subfamily 1, group D, member 1 P20393 Nucleus (Potential). Nucleus (GO:0005634) 12454280 nucleus 32 0 nucleus nucleus Theria Euteleostomi Metazoa NR1D2 HGNC:7963 nuclear receptor subfamily 1, group D, member 2 Q14995 Nucleus (By similarity). Nucleus (GO:0005634) 7997240 nucleus 34 0 nucleus nucleus Euteleostomi Deuterostomia Metazoa NR1H2 HGNC:7965 nuclear receptor subfamily 1, group H, member 2 P55055 Nucleus (Potential). Nucleus (GO:0005634) 12040022 nucleus 24 0 nucleus nucleus Deuterostomia Bilateria Metazoa NR1H3 HGNC:7966 nuclear receptor subfamily 1, group H, member 3 Q13133 Nucleus (Potential). Nucleus (GO:0005634) 11035776,7744246 nucleus 29 0 nucleus nucleus Deuterostomia Bilateria Metazoa NR1H4 HGNC:7967 nuclear receptor subfamily 1, group H, member 4 Q96RI1 Nucleus (Probable). Nucleus (GO:0005634) 10334992,10334993,17333335 nucleus 28 0 nucleus nucleus Amniota Euteleostomi Metazoa NR1I2 HGNC:7968 nuclear receptor subfamily 1, group I, member 2 O75469 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12606758,15322103,9784494,12606758 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Metazoa NR1I3 HGNC:7969 nuclear receptor subfamily 1, group I, member 3 Q14994 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7 (By similarity). Nucleus (GO:0005634) 8114692 nucleus 34 0 cytoplasm. nucleus multiple Theria Amniota Metazoa NR2C1 HGNC:7971 nuclear receptor subfamily 2, group C, member 1 P13056 Nucleus (By similarity). Nucleus, PML body (By similarity). Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation (By similarity). Nucleus (GO:0005634) 9795341 nucleus 87 0 nucleus nucleus Deuterostomia Bilateria Metazoa NR2C2 HGNC:7972 nuclear receptor subfamily 2, group C, member 2 P49116 Nucleus. Nucleus (GO:0005634) 12486131,15302918 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa NR2C2AP HGNC:30763 nuclear receptor 2C2-associated protein Q86WQ0 Nucleus. Nucleus (GO:0005634) 12486131 nucleus 100 0 nucleus nucleus Theria Eukaryota Eukaryota NR2E1 HGNC:7973 nuclear receptor subfamily 2, group E, member 1 Q9Y466 Nucleus (By similarity). Nucleus (GO:0005634) 8047143,11073974 nucleus 99 0 nucleus nucleus Bilateria Bilateria Metazoa NR2E3 HGNC:7974 nuclear receptor subfamily 2, group E, member 3 Q9Y5X4 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/15277507 nucleus 100 0 nucleus nucleus Bilateria Bilateria NA NR2F1 HGNC:7975 nuclear receptor subfamily 2, group F, member 1 P10589 Nucleus (Probable). Nucleus (GO:0005634) 10656770 nucleus 98 0 nucleus nucleus Bilateria Bilateria Metazoa NR2F2 HGNC:7976 nuclear receptor subfamily 2, group F, member 2 P24468 Nucleus. Nucleus (GO:0005634) 1899293 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa NR2F6 HGNC:7977 nuclear receptor subfamily 2, group F, member 6 P10588 Nucleus. Nucleus (GO:0005634) 12690040 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa NR3C1 HGNC:7978 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) P04150 Cytoplasm. Mitochondrion. Nucleus. Isoform Beta: Nucleus. Note=Localized largely in the nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 9348235/7769088,11238589,8898375,9348235,3597702,12000743,12810720,10187825,9353307,9703718,14739255,11238589,8898375,12730237,12000743,11080152,14739255,16888650,10887960,8288028 nucleus 44 1 cytoplasm. mitochondrion. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Metazoa NR3C2 HGNC:7979 nuclear receptor subfamily 3, group C, member 2 P08235 Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane. Nucleus (GO:0005634) 11960770 nucleus 45 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa NR4A1 HGNC:7980 nuclear receptor subfamily 4, group A, member 1 P22736 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10947977,17139261,10947977,10947977 nucleus 100 1 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Metazoa NR4A2 HGNC:7981 nuclear receptor subfamily 4, group A, member 2 P43354 Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14525795,14525795 nucleus 53 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa NR4A3 HGNC:7982 nuclear receptor subfamily 4, group A, member 3 Q92570 Nucleus (Potential). Nucleus (GO:0005634) 7811288 nucleus 49 0 nucleus nucleus Amniota Euteleostomi Metazoa NR5A1 HGNC:7983 nuclear receptor subfamily 5, group A, member 1 Q13285 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10230405,11479297 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa NR5A2 HGNC:7984 nuclear receptor subfamily 5, group A, member 2 O00482 Nucleus (Probable). Nucleus (GO:0005634) 9858833,11030332,9786908 nucleus 51 0 nucleus nucleus Bilateria Bilateria Opisthokonta NR6A1 HGNC:7985 nuclear receptor subfamily 6, group A, member 1 Q15406 Nucleus (Probable). Acrosome (GO:0001669); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12606326,11969338,12606326,11969338 nucleus 34 0 cytoplasm. lysosome. nucleus multiple Deuterostomia Bilateria Metazoa NRAP HGNC:7988 nebulin-related anchoring protein Q86VF7 Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. Cytoplasm (GO:0005737) 9295142 cytoplasm 30 0 cytoplasm cytoplasm Chordata Chordata Eukaryota NRARP HGNC:33843 NOTCH-regulated ankyrin repeat protein Q7Z6K4 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms NRAS HGNC:7989 neuroblastoma RAS viral (v-ras) oncogene homolog P01111 Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 10412982,10412982 cytoplasm 27 0 golgi apparatus golgi apparatus Euteleostomi Eukaryota Cell.Organisms NRBF2 HGNC:19692 nuclear receptor binding factor 2 Q96F24 Nucleus (By similarity). Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10786636,10786636 nucleus 88 0 cytoplasm. nucleus multiple Chordata Chordata Eumetazoa NRBP1 HGNC:7993 nuclear receptor binding protein 1 Q9UHY1 Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia. Nucleus (GO:0005634); Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10843813,15084397,11956649,11956649,15084397 cytoplasm 52 0 cytoplasm. endosome. nucleus multiple Human Euteleostomi Cell.Organisms NRBP2 HGNC:19339 nuclear receptor binding protein 2 Q9NSY0 Cytoplasm (By similarity). cytoplasm 94 0 cytoplasm cytoplasm Homininae Euteleostomi NA NRCAM HGNC:7994 neuronal cell adhesion molecule Q92823 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 8812479,9321706 plasma membrane 92 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms NRD1 HGNC:7995 nardilysin (N-arginine dibasic convertase) O43847 Plasma membrane (GO:0005886) 11432822 peroxisome 20 0 peroxisome peroxisome Eukaryota Cell.Organisms Cell.Organisms NRDE2 HGNC:20186 NRDE-2, necessary for RNA interference, domain containing Q9H7Z3 nucleus 8 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota NREP HGNC:16834 neuronal regeneration related protein Q16612 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10660586,10660586 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Amniota Amniota NRF1 HGNC:7996 nuclear respiratory factor 1 Q16656 Nucleus. Nucleus (GO:0005634) 7629110,11069771 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa NRG1 HGNC:7997 neuregulin 1 Q02297 Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Neuregulin-1: Secreted. Isoform 8: Nucleus. Isoform 9: Secreted. Isoform 10: Membrane; Single-pass type I membrane protein. Note=May possess an internal uncleaved signal sequence. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7876250,7876250,15219675 plasma membrane 14 1 cytoplasm. nucleus. plasma membrane. secreted multiple Tetrapoda Euteleostomi Bilateria NRG2 HGNC:7998 neuregulin 2 O14511 Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Neuregulin-2: Secreted (By similarity). Integral to membrane (GO:0016021) secreted 29 1 secreted secreted Mammalia Bilateria Eumetazoa NRG3 HGNC:7999 neuregulin 3 P56975 Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Neuregulin-3: Secreted (By similarity). Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form. Plasma membrane (GO:0005886) 9275162 plasma membrane 19 2 plasma membrane plasma membrane Tetrapoda Tetrapoda Chordata NRG4 HGNC:29862 neuregulin 4 Q8WWG1 Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Neuregulin-4: Secreted (By similarity). Integral to membrane (GO:0016021) 10348342 secreted 52 1 secreted secreted Euarchontoglires Amniota Eumetazoa NRGN HGNC:8000 neurogranin (protein kinase C substrate, RC3) Q92686 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 7898318,7898318 nucleus 57 0 cytoplasm. endoplasmic reticulum multiple Theria Theria Amniota NRIP1 HGNC:8001 nuclear receptor interacting protein 1 P48552 Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7641693,17053781,15879431,15060175,11266503,17053781,15879431 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Euteleostomi NRIP2 HGNC:23078 nuclear receptor interacting protein 2 Q9BQI9 Nucleus (By similarity). nucleus 77 0 nucleus nucleus Theria Euteleostomi Euteleostomi NRIP3 HGNC:1167 nuclear receptor interacting protein 3 Q9NQ35 nucleus 29 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota NRK HGNC:25391 Nik related kinase Q7Z2Y5 cytoplasm 29 0 cytoplasm cytoplasm Human Euarchontoglires Cell.Organisms NRL HGNC:8002 neural retina leucine zipper P54845 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11477108,16023139,11477108 nucleus 100 0 cytoplasm. nucleus multiple Theria Tetrapoda Metazoa NRM HGNC:8003 nurim (nuclear envelope membrane protein) Q8IXM6 Nucleus inner membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 10402458 nucleus membrane 100 5 nucleus. nucleus membrane multiple Chordata Cell.Organisms NA NRN1 HGNC:17972 neuritin 1 Q9NPD7 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Cell junction, synapse (By similarity). Extracellular (GO:0005576) secreted 83 1 secreted secreted Amniota Euteleostomi Craniata NRN1L HGNC:29811 neuritin 1-like Q496H8 Cell membrane; Lipid-anchor, GPI-anchor (Potential). secreted 87 1 secreted secreted Catarrhini Euteleostomi Euteleostomi NRP1 HGNC:8004 neuropilin 1 O14786 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10688880,9331348,10688880 secreted 23 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms NRP2 HGNC:8005 neuropilin 2 O60462 Membrane; Single-pass type I membrane protein. Isoform s9: Secreted. Plasma membrane (GO:0005886) 9331348 secreted 22 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms NRROS HGNC:24613 negative regulator of reactive oxygen species Q86YC3 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Amniota Eukaryota Cell.Organisms NRSN1 HGNC:17881 neurensin 1 Q8IZ57 Membrane; Multi-pass membrane protein (Potential). Note=Localizes mainly to neurites. Integral to membrane (GO:0016021) plasma membrane 26 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria NRSN2 HGNC:16229 neurensin 2 Q9GZP1 Membrane; Multi-pass membrane protein (Potential). plasma membrane 34 2 plasma membrane plasma membrane Human Amniota Bilateria NRTN HGNC:8007 neurturin Q99748 Secreted. Extracellular (GO:0005576) 9192899 secreted 100 0 secreted secreted Amniota Euteleostomi Craniata NRXN1 HGNC:8008 neurexin 1 P58400 Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre- synaptic membrane (By similarity). Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 11036064/1621094 secreted 11 2 plasma membrane plasma membrane Bilateria Bilateria Holozoa NRXN2 HGNC:8009 neurexin 2 P58401 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 1621094 plasma membrane 13 1 plasma membrane plasma membrane Bilateria Bilateria Holozoa NRXN3 HGNC:8010 neurexin 3 Q9HDB5 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Nucleus (GO:0005634) ,17081983 plasma membrane 59 1 plasma membrane plasma membrane Bilateria Bilateria Holozoa NSA2 HGNC:30728 NSA2 ribosome biogenesis homolog (S. cerevisiae) O95478 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Ribosome (GO:0005840) ,15635413,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NSD1 HGNC:14234 nuclear receptor binding SET domain protein 1 Q96L73 Nucleus. Chromosome (Probable). Nucleus (GO:0005634) 9628876 nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms NSDHL HGNC:13398 NAD(P) dependent steroid dehydrogenase-like Q15738 Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 14506130,14506130,15598749 endoplasmic reticulum membrane 15 1 endoplasmic reticulum. golgi apparatus. mitochondrion multiple Eukaryota Cell.Organisms NA NSF HGNC:8016 N-ethylmaleimide-sensitive factor P46459 Cytoplasm. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 8013662,8940356,1315316,16724110,15561729 cytoplasm 100 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms NSFL1C HGNC:15912 NSFL1 (p97) cofactor (p47) Q9UNZ2 Nucleus (By similarity). Golgi apparatus, Golgi stack (By similarity). Chromosome (By similarity). Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity). Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 17081983/12810701,9214505,12810701,12810701 cytoplasm 15 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota NSL1 HGNC:24548 NSL1, MIS12 kinetochore complex component Q96IY1 Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. Nucleus (GO:0005634); Kinetochore (GO:0000776) 15502821,15561729 nucleus 100 0 nucleus nucleus Amniota Deuterostomia Deuterostomia NSMAF HGNC:8017 neutral sphingomyelinase (N-SMase) activation associated factor Q92636 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12391233,12391233 endoplasmic reticulum 17 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms NSMCE1 HGNC:29897 non-SMC element 1 homolog (S. cerevisiae) Q8WV22 Nucleus. Chromosome, telomere (Probable). Nucleolus (GO:0005730) 15635413 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota NSMCE2 HGNC:26513 non-SMC element 2, MMS21 homolog (S. cerevisiae) Q96MF7 Nucleus. Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines. nucleus 100 0 nucleus nucleus Amniota Eukaryota Eukaryota NSMCE4A HGNC:25935 non-SMC element 4 homolog A (S. cerevisiae) Q9NXX6 Nucleus. Chromosome, telomere (Probable). nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota NSMF HGNC:29843 NMDA receptor synaptonuclear signaling and neuronal migration factor Q6X4W1 Nucleus. Nucleus envelope (By similarity). Nucleus membrane (By similarity). Nucleus matrix (By similarity). Cytoplasm. Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell membrane; Peripheral membrane protein. Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Membrane (By similarity). Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity). Plasma membrane (GO:0005886) 10898796 nucleus 78 0 cytoplasm. nucleus multiple Amniota Deuterostomia Metazoa NSRP1 HGNC:25305 nuclear speckle splicing regulatory protein 1 Q9H0G5 Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota NSUN2 HGNC:25994 NOP2/Sun RNA methyltransferase family, member 2 Q08J23 Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17215513,17215513,17081983,17081983 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms NSUN3 HGNC:26208 NOP2/Sun domain family, member 3 Q9H649 mitochondrion 22 0 mitochondrion mitochondrion Euteleostomi Eukaryota Cell.Organisms NSUN4 HGNC:31802 NOP2/Sun domain family, member 4 Q96CB9 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms NSUN5 HGNC:16385 NOP2/Sun domain family, member 5 Q96P11 nucleus 28 0 nucleus nucleus Eukaryota Cell.Organisms NA NSUN6 HGNC:23529 NOP2/Sun domain family, member 6 Q8TEA1 nucleus 23 0 nucleus nucleus NA NA Cell.Organisms NSUN7 HGNC:25857 NOP2/Sun domain family, member 7 Q8NE18 nucleus 10 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms NT5C HGNC:17144 5', 3'-nucleotidase, cytosolic Q8TCD5 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10681516,10681516 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Theria Cell.Organisms NT5C1A HGNC:17819 5'-nucleotidase, cytosolic IA Q9BXI3 Cytoplasm. Cytoplasm (GO:0005737) 11690631,11133996 cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms NT5C1B HGNC:17818 5'-nucleotidase, cytosolic IB Q96P26 Cytoplasm (By similarity). Nucleus (GO:0005634);Cytoplasm (GO:0005737) 17081983/ cytoplasm 70 0 nucleus nucleus Theria Euteleostomi Cell.Organisms NT5C2 HGNC:8022 5'-nucleotidase, cytosolic II P49902 Cytoplasm. Cytoplasm (GO:0005737) 7999131 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms NT5C3A HGNC:17820 5'-nucleotidase, cytosolic IIIA Q9H0P0 Cytoplasm (Potential). Isoform 2: Endoplasmic reticulum. Cytoplasm (GO:0005737) 7818506 mitochondrion 13 0 cytoplasm. endoplasmic reticulum multiple Bilateria Eukaryota Eukaryota NT5C3B HGNC:28300 5'-nucleotidase, cytosolic IIIB Q969T7 Cytoplasm (Potential). cytoplasm 31 0 cytoplasm cytoplasm Bilateria Eukaryota NA NT5DC1 HGNC:21556 5'-nucleotidase domain containing 1 Q5TFE4 Cytoplasm (GO:0005737) cytoplasm 9 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NT5DC2 HGNC:25717 5'-nucleotidase domain containing 2 Q9H857 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NT5DC3 HGNC:30826 5'-nucleotidase domain containing 3 Q86UY8 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms NT5DC4 HGNC:27678 5'-nucleotidase domain containing 4 Q86YG4 cytoplasm 57 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms NT5E HGNC:8021 5'-nucleotidase, ecto (CD73) P21589 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 12170585,11149913 secreted 24 1 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms NT5M HGNC:15769 5',3'-nucleotidase, mitochondrial Q9NPB1 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10899995,12124385,12124385 mitochondrion 100 0 cytoplasm. mitochondrion multiple Euteleostomi Euteleostomi Cell.Organisms NTAN1 HGNC:29909 N-terminal asparagine amidase Q96AB6 Cytoplasm (By similarity). cytoplasm 90 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota NTF3 HGNC:8023 neurotrophin 3 P20783 Secreted. secreted 100 0 secreted secreted Tetrapoda Euteleostomi Bilateria NTF4 HGNC:8024 neurotrophin 4 P34130 Secreted. Extracellular (GO:0005576) 8061955 secreted 100 0 secreted secreted Theria Tetrapoda Boreoeutheria NTHL1 HGNC:8028 nth endonuclease III-like 1 (E. coli) P78549 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 12531031,12531031,9705289 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms NTM HGNC:17941 neurotrimin Q9P121 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) secreted 11 0 secreted secreted Tetrapoda Bilateria Cell.Organisms NTMT1 HGNC:23373 N-terminal Xaa-Pro-Lys N-methyltransferase 1 Q9BV86 Nucleus. Note=Predominantly nuclear. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms NTN1 HGNC:8029 netrin 1 O95631 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 9950216,12636918,11356879,12810718 secreted 99 0 secreted secreted Bilateria Bilateria Eukaryota NTN3 HGNC:8030 netrin 3 O00634 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 9143507 secreted 84 0 secreted secreted Bilateria Bilateria Eukaryota NTN4 HGNC:13658 netrin 4 Q9HB63 Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. Extracellular (GO:0005576) 11038171 secreted 19 0 secreted secreted Chordata Chordata Holozoa NTN5 HGNC:25208 netrin 5 Q8WTR8 Secreted (Potential). secreted 32 0 secreted secreted Euarchontoglires Mammalia Holozoa NTNG1 HGNC:23319 netrin G1 Q9Y2I2 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Plasma membrane (GO:0005886) 10964959 secreted 27 0 secreted secreted Euteleostomi Euteleostomi Holozoa NTNG2 HGNC:14288 netrin G2 Q96CW9 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Plasma membrane (GO:0005886) 11804778 secreted 25 0 secreted secreted Euteleostomi Euteleostomi Holozoa NTPCR HGNC:28204 nucleoside-triphosphatase, cancer-related Q9BSD7 cytoplasm 54 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms NTRK1 HGNC:8031 neurotrophic tyrosine kinase, receptor, type 1 P04629 Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein (By similarity). Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 1656363,10103137,10103137 plasma membrane 36 1 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms NTRK2 HGNC:8032 neurotrophic tyrosine kinase, receptor, type 2 Q16620 Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein (By similarity). Note=Internalized to endosomes upon ligand- binding (By similarity). Integral to membrane (GO:0016021) 1710174 plasma membrane 37 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms NTRK3 HGNC:8033 neurotrophic tyrosine kinase, receptor, type 3 Q16288 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1326636 plasma membrane 32 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms NTS HGNC:8038 neurotensin P30990 Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles. Extracellular (GO:0005576) 409699,6754769 nucleus 29 0 secreted secreted Tetrapoda Euteleostomi Euteleostomi NTSR1 HGNC:8039 neurotensin receptor 1 (high affinity) P30989 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10930533 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa NTSR2 HGNC:8040 neurotensin receptor 2 O95665 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11801734 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa NUAK1 HGNC:14311 NUAK family, SNF1-like kinase, 1 O60285 Nucleus. Cytoplasm. Nucleus (GO:0005634) 17081983 cytoplasm 20 0 cytoplasm. nucleus multiple Human Bilateria Cell.Organisms NUAK2 HGNC:29558 NUAK family, SNF1-like kinase, 2 Q9H093 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14575707,14575707 cytoplasm 21 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms NUB1 HGNC:17623 negative regulator of ubiquitin-like proteins 1 Q9Y5A7 Nucleus. Note=Predominantly nuclear. Nucleus (GO:0005634) 14757770,11259415 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota NUBP1 HGNC:8041 nucleotide binding protein 1 P53384 Cytoplasm. Nucleus (GO:0005634) cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms NUBP2 HGNC:8042 nucleotide binding protein 2 Q9Y5Y2 Nucleus (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Enriched at the centrosomes during mitosis (By similarity). Cytoplasm (GO:0005737) 12970194 cytoplasm 41 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms NUBPL HGNC:20278 nucleotide binding protein-like Q8TB37 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms NUCB1 HGNC:8043 nucleobindin 1 Q02818 Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side (By similarity). Cytoplasm (By similarity). Note=A small fraction of the protein may be cytoplasmic (By similarity). Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9647645,1520323,11752444,9589460 nucleus 12 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Bilateria Bilateria Holozoa NUCB2 HGNC:8044 nucleobindin 2 P80303 Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum (By similarity). Nucleus envelope (By similarity). Nesfatin-1: Secreted. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634) 11749975,11749975,7811391,17036007,7811391,7811391,17036007 cytoplasm 13 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Bilateria Bilateria Holozoa NUCKS1 HGNC:29923 nuclear casein kinase and cyclin-dependent kinase substrate 1 Q9H1E3 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11298763,12413487,17081983,12413487,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Euteleostomi NUDC HGNC:8045 nudC nuclear distribution protein Q9Y266 Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10210332,17081983,10210332 cytoplasm 48 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NUDCD1 HGNC:24306 NudC domain containing 1 Q96RS6 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Nucleus. cytoplasm 29 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota NUDCD2 HGNC:30535 NudC domain containing 2 Q8WVJ2 Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis. cytoplasm 18 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota NUDCD3 HGNC:22208 NudC domain containing 3 Q8IVD9 cytoplasm 18 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota NUDT1 HGNC:8048 nudix (nucleoside diphosphate linked moiety X)-type motif 1 P36639 Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Isoform p26: Cytoplasm. Mitochondrion matrix. Cytoplasm (GO:0005737); Mitochondrial matrix (GO:0005759); Nucleus (GO:0005634) 7782328,10536140,7782328,10536140,7782328 peroxisome 28 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms NUDT10 HGNC:17621 nudix (nucleoside diphosphate linked moiety X)-type motif 10 Q8NFP7 Cytoplasm (Probable). Cytoplasm (GO:0005737) 12121577 cytoplasm 99 0 cytoplasm cytoplasm Human Opisthokonta NA NUDT11 HGNC:18011 nudix (nucleoside diphosphate linked moiety X)-type motif 11 Q96G61 Cytoplasm. Cytoplasm (GO:0005737) 12121577 cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eutheria NA NUDT12 HGNC:18826 nudix (nucleoside diphosphate linked moiety X)-type motif 12 Q9BQG2 Peroxisome. Peroxisome (GO:0005777); Cytoplasm (GO:0005737) 12790796,12790796 peroxisome 100 0 cytoplasm. peroxisome multiple Cell.Organisms Cell.Organisms Cell.Organisms NUDT13 HGNC:18827 nudix (nucleoside diphosphate linked moiety X)-type motif 13 Q86X67 peroxisome 32 0 peroxisome peroxisome Cell.Organisms Cell.Organisms Cell.Organisms NUDT14 HGNC:20141 nudix (nucleoside diphosphate linked moiety X)-type motif 14 O95848 Cytoplasm. Cytoplasm (GO:0005737) 12429023 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms NUDT15 HGNC:23063 nudix (nucleoside diphosphate linked moiety X)-type motif 15 Q9NV35 Nucleus (GO:0005634) 12767940 cytoplasm 31 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms NUDT16 HGNC:26442 nudix (nucleoside diphosphate linked moiety X)-type motif 16 Q96DE0 Nucleus. Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus. Cytoplasm. Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). cytoplasm 40 0 cytoplasm. nucleus multiple Theria Chordata Metazoa NUDT16L1 HGNC:28154 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 Q9BRJ7 Cytoplasm (By similarity). Nucleolus (GO:0005730) 15635413 cytoplasm 44 0 nucleus nucleus Amniota Amniota Metazoa NUDT17 HGNC:26618 nudix (nucleoside diphosphate linked moiety X)-type motif 17 P0C025 mitochondrion 34 0 mitochondrion mitochondrion Theria Deuterostomia NA NUDT18 HGNC:26194 nudix (nucleoside diphosphate linked moiety X)-type motif 18 Q6ZVK8 mitochondrion 19 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms NUDT19 HGNC:32036 nudix (nucleoside diphosphate linked moiety X)-type motif 19 A8MXV4 Peroxisome (By similarity). Mitochondrion (By similarity). mitochondrion 27 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms NUDT2 HGNC:8049 nudix (nucleoside diphosphate linked moiety X)-type motif 2 P50583 Cytoplasm (GO:0005737) 9650578 mitochondrion 20 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms NUDT21 HGNC:13870 nudix (nucleoside diphosphate linked moiety X)-type motif 21 O43809 Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8626397,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota NUDT22 HGNC:28189 nudix (nucleoside diphosphate linked moiety X)-type motif 22 Q9BRQ3 cytoplasm 20 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota NUDT3 HGNC:8050 nudix (nucleoside diphosphate linked moiety X)-type motif 3 O95989 Cytoplasm (Probable). cytoplasm 72 0 cytoplasm cytoplasm Opisthokonta Eukaryota NA NUDT4 HGNC:8051 nudix (nucleoside diphosphate linked moiety X)-type motif 4 Q9NZJ9 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms NUDT5 HGNC:8052 nudix (nucleoside diphosphate linked moiety X)-type motif 5 Q9UKK9 cytoplasm 62 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms NUDT6 HGNC:8053 nudix (nucleoside diphosphate linked moiety X)-type motif 6 P53370 Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 11266510,15247275,15247275,9406864,15247275 cytoplasm 27 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms NUDT7 HGNC:8054 nudix (nucleoside diphosphate linked moiety X)-type motif 7 P0C024 Peroxisome (By similarity). peroxisome 60 0 peroxisome peroxisome Deuterostomia Cell.Organisms Cell.Organisms NUDT8 HGNC:8055 nudix (nucleoside diphosphate linked moiety X)-type motif 8 Q8WV74 Mitochondrion (By similarity). mitochondrion 79 1 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms NUDT9 HGNC:8056 nudix (nucleoside diphosphate linked moiety X)-type motif 9 Q9BW91 Isoform 1: Mitochondrion. Cytoplasm (GO:0005737);Mitochondrion (GO:0005739) 11825615/12427752 mitochondrion 100 0 cytoplasm. mitochondrion multiple Bilateria Bilateria Cell.Organisms NUF2 HGNC:14621 NUF2, NDC80 kinetochore complex component Q9BZD4 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Chromosome (GO:0005694); Kinetochore (GO:0000776) 12438418,11685532,11685532,11266451,12438418,15561729 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota NUFIP1 HGNC:8057 nuclear fragile X mental retardation protein interacting protein 1 Q9UHK0 Nucleus. Note=Distributed in the nucleus in a dot-like pattern. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Ribosome (GO:0005840) 10556305,12941608,12941608,12941608 nucleus 100 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota NUFIP2 HGNC:17634 nuclear fragile X mental retardation protein interacting protein 2 Q7Z417 Nucleus. Cytoplasm. Note=Distribution is cell cycle-modulated, being cytoplasmic in the G2/M phase and accumulating in nucleus during the G1 phase. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12837692,17000644,12837692 nucleus 85 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata NUGGC HGNC:33550 nuclear GTPase, germinal center associated Q68CJ6 Nucleus. nucleus 100 0 nucleus nucleus Amniota Opisthokonta Opisthokonta NUMA1 HGNC:8059 nuclear mitotic apparatus protein 1 Q14980 Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Isoform Numa-m: Cytoplasm. Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytosol (GO:0005829); Microtubule (GO:0005874); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 1541630,17081983,11790298,15635413,16263121,15561729,15598749,17081983 cytoplasm 3 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Deuterostomia Deuterostomia NUMB HGNC:8060 numb homolog (Drosophila) P49757 Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Cytosol (GO:0005829);Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8755477,17203073,11121447,11121447,11121447,17203073/17203073/17081983,17081983 cytoplasm 51 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Bilateria Bilateria Holozoa NUMBL HGNC:8061 numb homolog (Drosophila)-like Q9Y6R0 Cytoplasm (By similarity). Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8755477,17081983,17081983 cytoplasm 95 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa NUP107 HGNC:29914 nucleoporin 107kDa P57740 Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis. Nucleus (GO:0005634); Kinetochore (GO:0000776); Microtubule (GO:0005874) 12552102,17363900,15561729 nucleus 62 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota NUP133 HGNC:18016 nucleoporin 133kDa Q8WUM0 Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Kinetochore (GO:0000776); Microtubule (GO:0005874) 12705868,12705868,17363900,15561729 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta NUP153 HGNC:8062 nucleoporin 153kDa P49790 Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 9847314,9275187,15561729 nucleus 14 0 nucleus. nucleus membrane multiple Chordata Chordata Opisthokonta NUP155 HGNC:8063 nucleoporin 155kDa O75694 Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nuclear membrane (GO:0005635) 14645504,14645504,15598749,15561729 nucleus 67 0 cytoplasm. mitochondrion. nucleus. nucleus membrane multiple Eukaryota Eukaryota Eukaryota NUP160 HGNC:18017 nucleoporin 160kDa Q12769 Nucleus, nuclear pore complex. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 11684705,17081983,15561729 nucleus 100 0 nucleus. nucleus membrane multiple Euteleostomi Eukaryota Eukaryota NUP188 HGNC:17859 nucleoporin 188kDa Q5SRE5 Nucleus, nuclear pore complex (Probable). Nuclear membrane (GO:0005635) secreted 86 5 nucleus nucleus Deuterostomia Eukaryota Eukaryota NUP205 HGNC:18658 nucleoporin 205kDa Q92621 Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Note=Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 9348540,15561729 nucleus 39 2 nucleus. nucleus membrane multiple Euteleostomi Eukaryota Eukaryota NUP210 HGNC:30052 nucleoporin 210kDa Q8TEM1 Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Nuclear membrane (GO:0005635) 8672508,17081983,15598749,15561729 plasma membrane 34 1 endoplasmic reticulum membrane. mitochondrion. nucleus. nucleus membrane multiple Bilateria Eukaryota Eukaryota NUP210L HGNC:29915 nucleoporin 210kDa-like Q5VU65 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 34 1 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota NUP214 HGNC:8064 nucleoporin 214kDa P35658 Nucleus, nuclear pore complex. Note=Cytoplasmic filaments. Nucleus (GO:0005634) 8108440 nucleus 100 0 nucleus nucleus Chordata Opisthokonta Opisthokonta NUP35 HGNC:29797 nucleoporin 35kDa Q8NFH5 Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightly associated with the nuclear membrane and lamina. Nuclear membrane (GO:0005635); Nucleus (GO:0005634) 12196509,15561729,17081983 nucleus 48 0 nucleus. nucleus membrane multiple Deuterostomia Eukaryota Eukaryota NUP37 HGNC:29929 nucleoporin 37kDa Q8NFH4 Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 12196509,15146057,15561729 nucleus 100 0 nucleus. nucleus membrane multiple Euteleostomi Opisthokonta Cell.Organisms NUP43 HGNC:21182 nucleoporin 43kDa Q8NFH3 Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 15146057,12196509,15561729 nucleus 100 0 nucleus. nucleus membrane multiple Bilateria Eukaryota Cell.Organisms NUP50 HGNC:8065 nucleoporin 50kDa Q9UKX7 Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10891500,12176322,12176322,17081983 cytoplasm 58 0 cytoplasm. nucleus multiple Chordata Bilateria Opisthokonta NUP54 HGNC:17359 nucleoporin 54kDa Q7Z3B4 Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nuclear membrane (GO:0005635) 8707840,8707840,15561729 nucleus 29 0 cytoplasm. nucleus. nucleus membrane multiple Bilateria Eukaryota Cell.Organisms NUP62 HGNC:8066 nucleoporin 62kDa P37198 Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle. Nuclear membrane (GO:0005635) 8589458 nucleus 22 0 cytoplasm. nucleus. nucleus membrane multiple Deuterostomia Eukaryota Eukaryota NUP62CL HGNC:25960 nucleoporin 62kDa C-terminal like Q9H1M0 cytoplasm 24 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota NUP85 HGNC:8734 nucleoporin 85kDa Q9BW27 Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon l2 stimulation translocates from the cytoplasm to the membrane and colocalizes with R2 at the front of migrating cells. Centrosome (GO:0005813) 8124707,15561729 nucleus 46 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota NUP88 HGNC:8067 nucleoporin 88kDa Q99567 Nucleus, nuclear pore complex. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 9049309,15561729 nucleus 100 0 nucleus. nucleus membrane multiple Eutheria Bilateria Opisthokonta NUP93 HGNC:28958 nucleoporin 93kDa Q8N1F7 Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein (By similarity). Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Nuclear membrane (GO:0005635) ,15598749,15561729 nucleus 10 1 mitochondrion. nucleus multiple Opisthokonta Eukaryota Eukaryota NUP98 HGNC:8068 nucleoporin 98kDa P52948 Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Note=Nup96 is localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket. Dissociates from the dissasembled NPC structure early during prophase of mitosis. Colocalized with NUP153 and TPR to the nuclear basket of NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nuclear membrane (GO:0005635); Mitochondrion (GO:0005739) 17081983,17081983/12589057,7736573,9275187,12589057,17159900,15561729,15598749 nucleus 19 0 cytoplasm. mitochondrion. nucleus. nucleus membrane multiple Bilateria Eukaryota Eukaryota NUPL1 HGNC:20261 nucleoporin like 1 Q9BVL2 Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity). Nucleus (GO:0005634); Mitochondrion (GO:0005739) ,15598749 nucleus 23 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta NUPL2 HGNC:17010 nucleoporin like 2 O15504 Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Excluded from the nucleolus. Nuclear membrane (GO:0005635) 12228227 nucleus 27 0 nucleus. nucleus membrane multiple Chordata Opisthokonta Eumetazoa NUPR1 HGNC:29990 nuclear protein, transcriptional regulator, 1 O60356 Nucleus. Nucleus (GO:0005634) 10092851 nucleus 100 0 nucleus nucleus Mammalia Bilateria Eumetazoa NUPR1L HGNC:44164 nuclear protein, transcriptional regulator, 1-like A6NF83 nucleus 91 0 nucleus nucleus NA NA Eumetazoa NUS1 HGNC:21042 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) Q96E22 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Cell.Organisms NUSAP1 HGNC:18538 nucleolar and spindle associated protein 1 Q9BXS6 Cytoplasm (By similarity). Nucleus, nucleolus (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Chromosome (By similarity). Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 12963707,15635413,12963707,12963707 nucleus 83 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa NUTF2 HGNC:13722 nuclear transport factor 2 P61970 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7744965,10679025,10679025 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota NUTM1 HGNC:29919 NUT midline carcinoma, family member 1 Q86Y26 Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Nucleus (GO:0005634) 12543779 nucleus 84 0 cytoplasm. nucleus multiple Mammalia Mammalia Amniota NUTM2A HGNC:23438 NUT family member 2A Q8IVF1 nucleus 84 0 nucleus nucleus Eutheria Eutheria Amniota NUTM2D HGNC:23447 NUT family member 2D Q5VT03 nucleus 87 0 nucleus nucleus Eutheria Eutheria Amniota NUTM2F HGNC:23450 NUT family member 2F A1L443 secreted 17 0 secreted secreted Eutheria Eutheria Craniata NUTM2G HGNC:23449 NUT family member 2G Q5VZR2 nucleus 18 0 nucleus nucleus Eutheria Eutheria Amniota NVL HGNC:8070 nuclear VCP-like O15381 Nucleus, nucleolus. Nucleoplasm (GO:0005654) 9286697,15469983 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms NWD1 HGNC:27619 NACHT and WD repeat domain containing 1 Q149M9 cytoplasm 7 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms NWD2 HGNC:29229 NACHT and WD repeat domain containing 2 Q9ULI1 cytoplasm 2 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms NXF1 HGNC:8071 nuclear RNA export factor 1 Q9UBU9 Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Nucleus (GO:0005634) 10668806 nucleus 70 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NXF2 HGNC:8072 nuclear RNA export factor 2 Q9GZY0 Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Nuclear membrane (GO:0005635) 11073998,11073998 nucleus 45 0 cytoplasm. nucleus. nucleus membrane multiple Opisthokonta Eukaryota Eukaryota NXF2B HGNC:23984 nuclear RNA export factor 2B Q9GZY0 Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm. nucleus 45 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NXF3 HGNC:8073 nuclear RNA export factor 3 Q9H4D5 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11545741,11545741 nucleus 39 0 cytoplasm. nucleus multiple Eutheria Eutheria Opisthokonta NXF5 HGNC:8075 nuclear RNA export factor 5 Q9H1B4 Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11566096,11566096 nucleus 47 0 cytoplasm. nucleus multiple Human Human Opisthokonta NXN HGNC:18008 nucleoredoxin Q6DKJ4 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9119370,10903915,10903915 cytoplasm 44 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms NXNL1 HGNC:25179 nucleoredoxin-like 1 Q96CM4 Nucleus outer membrane (By similarity). Extracellular (GO:0005576) 15220920 cytoplasm 54 0 secreted secreted Euteleostomi Eukaryota Eukaryota NXNL2 HGNC:30482 nucleoredoxin-like 2 Q5VZ03 cytoplasm 42 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms NXPE1 HGNC:28527 neurexophilin and PC-esterase domain family, member 1 Q8N323 Secreted. secreted 100 0 secreted secreted Mammalia Chordata Bilateria NXPE2 HGNC:26331 neurexophilin and PC-esterase domain family, member 2 Q96DL1 Membrane; Single-pass membrane protein (Potential). secreted 63 0 secreted secreted Human Human Opisthokonta NXPE3 HGNC:28238 neurexophilin and PC-esterase domain family, member 3 Q969Y0 Secreted (Potential). secreted 15 0 secreted secreted Deuterostomia Deuterostomia Bilateria NXPE4 HGNC:23117 neurexophilin and PC-esterase domain family, member 4 Q6UWF7 Secreted (Potential). secreted 62 0 secreted secreted Mammalia Chordata Bilateria NXPH1 HGNC:20693 neurexophilin 1 P58417 Secreted (Potential). Extracellular (GO:0005576) 9570794 secreted 86 0 secreted secreted Euteleostomi Euteleostomi Chordata NXPH2 HGNC:8076 neurexophilin 2 O95156 Secreted (Potential). Extracellular (GO:0005576) 8699246 secreted 31 0 secreted secreted Euteleostomi Euteleostomi Craniata NXPH3 HGNC:8077 neurexophilin 3 O95157 Secreted (Potential). Extracellular (GO:0005576) 8699246,9570794 secreted 75 0 secreted secreted Human Tetrapoda Chordata NXPH4 HGNC:8078 neurexophilin 4 O95158 Secreted (Potential). Extracellular (GO:0005576) 9570794 nucleus 17 0 secreted secreted Human Human Craniata NXT1 HGNC:15913 NTF2-like export factor 1 Q9UKK6 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10228171,10567585,11756420,10228171,10567585,11756420 cytoplasm 20 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NXT2 HGNC:18151 nuclear transport factor 2-like export factor 2 Q9NPJ8 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634) 11073998 cytoplasm 14 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota NYAP1 HGNC:22009 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 Q6ZVC0 cytoplasm 24 0 cytoplasm cytoplasm Theria Euteleostomi Craniata NYAP2 HGNC:29291 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Q9P242 cytoplasm 31 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata NYNRIN HGNC:20165 NYN domain and retroviral integrase containing Q9P2P1 Membrane; Multi-pass membrane protein (Potential). cytoplasm 38 2 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms NYX HGNC:8082 nyctalopin Q9GZU5 Secreted, extracellular space, extracellular matrix (By similarity). Plasma membrane (GO:0005886) 11062471 secreted 17 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria OAF HGNC:28752 OAF homolog (Drosophila) Q86UD1 secreted 85 0 secreted secreted Tetrapoda Bilateria Eumetazoa OARD1 HGNC:21257 O-acyl-ADP-ribose deacylase 1 Q9Y530 Nucleus (GO:0005634) cytoplasm 30 0 cytoplasm cytoplasm Amniota Cell.Organisms Cell.Organisms OAS1 HGNC:8086 2'-5'-oligoadenylate synthetase 1, 40/46kDa P00973 Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted (By similarity). Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 3754863,15561729 cytoplasm 26 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Theria Amniota Holozoa OAS2 HGNC:8087 2'-5'-oligoadenylate synthetase 2, 69/71kDa P29728 Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730) 2211721,9521856,2211721,9521856,2211721,2440675,2440675,9521856,9521856 nucleus 34 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Theria Theria Holozoa OAS3 HGNC:8088 2'-5'-oligoadenylate synthetase 3, 100kDa Q9Y6K5 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Nucleus (GO:0005634) 9880533,2440675,2440675,14718574,15561729 nucleus 29 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Theria Theria Holozoa OASL HGNC:8090 2'-5'-oligoadenylate synthetase-like Q15646 Isoform p56: Nucleus, nucleolus. Cytoplasm. Isoform p30: Cytoplasm. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9826176,9826176,9826176 cytoplasm 59 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota OAT HGNC:8091 ornithine aminotransferase P04181 Mitochondrion matrix. Mitochondrion (GO:0005739) 3456579,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms OAZ1 HGNC:8095 ornithine decarboxylase antizyme 1 P54368 Cytoplasm (GO:0005737) 2724368 nucleus 45 0 cytoplasm cytoplasm Euteleostomi Bilateria Eumetazoa OAZ2 HGNC:8096 ornithine decarboxylase antizyme 2 O95190 Nucleus (By similarity). nucleus 99 0 nucleus nucleus Amniota Euteleostomi Eumetazoa OAZ3 HGNC:8097 ornithine decarboxylase antizyme 3 Q9UMX2 Nucleus. Cytoplasm (By similarity). nucleus 24 0 nucleus nucleus Human Human Eumetazoa OBFC1 HGNC:26200 oligonucleotide/oligosaccharide-binding fold containing 1 Q9H668 Nucleus. Chromosome, telomere. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota OBP2A HGNC:23380 odorant binding protein 2A Q9NY56 Secreted (Probable). Extracellular (GO:0005576) 12044155 secreted 33 0 secreted secreted Homininae Eutheria Euteleostomi OBP2B HGNC:23381 odorant binding protein 2B Q9NPH6 Secreted (Probable). Extracellular (GO:0005576) 12044155 secreted 34 0 secreted secreted Homininae Eutheria NA OBSCN HGNC:15719 obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Q5VST9 Isoform 3: Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z- disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells. Sarcoplasm (GO:0016528) 12631729,11448995,12527750,16962094 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms OBSL1 HGNC:29092 obscurin-like 1 O75147 Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Note=Co-localizes with CUL7 at the Golgi apparatus in neurons. Perinuclear region (GO:0048471); Nuclear membrane (GO:0005635) 17289344,17289344 cytoplasm 14 0 cytoplasm. golgi apparatus. nucleus membrane multiple Bilateria Cell.Organisms Cell.Organisms OC90 HGNC:8100 otoconin 90 Q02509 Secreted (By similarity). Extracellular (GO:0005576) 9027484 secreted 21 0 secreted secreted NA NA Eumetazoa OCA2 HGNC:8101 oculocutaneous albinism II Q04671 Melanosome membrane; Multi-pass membrane protein. Endosome (GO:0005768) 10671067 plasma membrane 16 12 endosome. melanosome membrane multiple Euteleostomi Cell.Organisms Cell.Organisms OCEL1 HGNC:26221 occludin/ELL domain containing 1 Q9H607 nucleus 13 0 nucleus nucleus Theria Euteleostomi Bilateria OCIAD1 HGNC:16074 OCIA domain containing 1 Q9NX40 Endosome (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 5 2 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa OCIAD2 HGNC:28685 OCIA domain containing 2 Q56VL3 Endosome (Probable). cytoplasm 3 2 endosome endosome Euteleostomi Bilateria Bilateria OCLM HGNC:8103 oculomedin Q9Y5M6 Integral to membrane (GO:0016021) mitochondrion membrane 14 1 mitochondrion membrane mitochondrion membrane NA NA Homo OCLN HGNC:8104 occludin Q16625 Membrane; Multi-pass membrane protein. Cell junction, tight junction. Plasma membrane (GO:0005886); Cell junction (GO:0030054) 10497311,10591624,9243183,19017651,16616143 nucleus 19 4 plasma membrane plasma membrane Euteleostomi Euteleostomi NA OCM HGNC:8105 oncomodulin P0CE72 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata OCM2 HGNC:34396 oncomodulin 2 P0CE71 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9405492,9405492 cytoplasm 22 0 cytoplasm. nucleus multiple NA NA Craniata OCRL HGNC:8108 oculocerebrorenal syndrome of Lowe Q01968 Cytoplasmic vesicle, phagosome membrane (By similarity). Early endosome membrane. Membrane, clathrin-coated pit. Cell projection, cilium, photoreceptor outer segment. Cytoplasmic vesicle (By similarity). Endosome (By similarity). Golgi apparatus, trans-Golgi network (By similarity). Note=Also found on macropinosomes. Golgi apparatus (GO:0005794); Cell projection (GO:0042995); Lysosome (GO:0005764); Early endosome (GO:0005769); Clathrin-coated vesicle (GO:0030136); Golgi membrane (GO:0000139); Cytoplasm (GO:0005737) 9593760,15917292,10639484,16902405,16902405,9838104,15917292,16902405,15917292,15917292,10639484,16902405 cytoplasm 23 0 cytoplasm. endosome. golgi apparatus. golgi apparatus membrane. lysosome multiple Bilateria Eukaryota Eukaryota OCSTAMP HGNC:16116 osteoclast stimulatory transmembrane protein Q9BR26 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 24 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Euteleostomi ODAM HGNC:26043 odontogenic, ameloblast asssociated A1E959 Secreted (By similarity). secreted 55 0 secreted secreted Eutheria Eutheria Eutheria ODC1 HGNC:8109 ornithine decarboxylase 1 P11926 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10064588,10064588,10588659 mitochondrion 40 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ODF1 HGNC:8113 outer dense fiber of sperm tails 1 Q14990 Cytoplasm (GO:0005737) 8873064 cytoplasm 29 0 cytoplasm cytoplasm Theria Amniota Olfactores ODF2 HGNC:8114 outer dense fiber of sperm tails 2 Q5BJF6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. Cytoplasm (GO:0005737) 9740324 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota ODF2L HGNC:29225 outer dense fiber of sperm tails 2-like Q9ULJ1 cytoplasm 15 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa ODF3 HGNC:19905 outer dense fiber of sperm tails 3 Q96PU9 Cytoplasm (By similarity). Note=Expressed in the cytoplasmic lobe of spermatids (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Cell projection (GO:0042995) 11870087,11870087,11870087 cytoplasm 92 0 cytoplasm. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota ODF3B HGNC:34388 outer dense fiber of sperm tails 3B A8MYP8 cytoplasm 35 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ODF3L1 HGNC:28735 outer dense fiber of sperm tails 3-like 1 Q8IXM7 cytoplasm 19 0 cytoplasm cytoplasm Mammalia Chordata Eukaryota ODF3L2 HGNC:26841 outer dense fiber of sperm tails 3-like 2 Q3SX64 cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota ODF4 HGNC:19056 outer dense fiber of sperm tails 4 Q2M2E3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12728016 plasma membrane 16 4 plasma membrane plasma membrane Eutheria Eutheria Eutheria OFCC1 HGNC:21017 orofacial cleft 1 candidate 1 Q8IZS5 nucleus 52 0 nucleus nucleus Mammalia Mammalia Holozoa OFD1 HGNC:2567 oral-facial-digital syndrome 1 O75665 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Note=Localizes to centriole distal ends (By similarity). Nucleus (GO:0005634) 11734546 cytoplasm 15 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota OGDH HGNC:8124 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Q02218 Mitochondrion matrix. Mitochondrion (GO:0005739) 8020988,15033988,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms OGDHL HGNC:25590 oxoglutarate dehydrogenase-like Q9ULD0 Mitochondrion matrix (By similarity). mitochondrion 74 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms OGFOD1 HGNC:25585 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Q8N543 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. nucleus 20 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms OGFOD2 HGNC:25823 2-oxoglutarate and iron-dependent oxygenase domain containing 2 Q6N063 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms OGFOD3 HGNC:26174 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Q6PK18 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 14 1 nucleus nucleus Deuterostomia Bilateria Holozoa OGFR HGNC:15768 opioid growth factor receptor Q9NZT2 Cytoplasm (By similarity). Nucleus (By similarity). Note=The OGF/OGFR complex is probably translocated to the nucleus. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/11890982,12650964 secreted 32 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms OGFRL1 HGNC:21378 opioid growth factor receptor-like 1 Q5TC84 nucleus 52 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms OGG1 HGNC:8125 8-oxoguanine DNA glycosylase O15527 Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Isoform 1A: Nucleus. Isoform 2A: Mitochondrion. Nucleus (GO:0005634);Mitochondrion (GO:0005739);Mitochondrion (GO:0005739); Nucleus (GO:0005634); Nuclear matrix (GO:0016363); Cytoplasm (GO:0005737) 10233168/10233168/12244119,12531019,12034821,12034821 nucleus 28 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms OGN HGNC:8126 osteoglycin P20774 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 2326263 secreted 85 0 secreted secreted Euteleostomi Euteleostomi Metazoa OGT HGNC:8127 O-linked N-acetylglucosamine (GlcNAc) transferase O15294 Isoform 2: Mitochondrion. Membrane. Isoform 3: Cytoplasm. Nucleus. Cell membrane. Isoform 4: Cytoplasm. Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10580430,12911634,9083067,17000644,12724313,12504895,12538765,12911634,9083067 cytoplasm 12 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms OIP5 HGNC:20300 Opa interacting protein 5 O43482 Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. Plasma membrane (GO:0005886) nucleus 100 0 nucleus nucleus Theria Amniota Holozoa OIT3 HGNC:29953 oncoprotein induced transcript 3 Q8WWZ8 Nucleus envelope. Note=Can be secreted into blood. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12939600,12939600,12939600 nucleus 100 0 cytoplasm. nucleus. secreted multiple Deuterostomia Deuterostomia Eukaryota OLA1 HGNC:28833 Obg-like ATPase 1 Q9NTK5 Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. Nucleolus (GO:0005730) 15635413 cytoplasm 44 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms OLAH HGNC:25625 oleoyl-ACP hydrolase Q9NV23 secreted 22 0 secreted secreted Euteleostomi Cell.Organisms Cell.Organisms OLFM1 HGNC:17187 olfactomedin 1 Q99784 Secreted (Potential). Cell junction, synapse (By similarity). Endoplasmic reticulum (GO:0005783) 9039501 plasma membrane 27 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Deuterostomia Bilateria OLFM2 HGNC:17189 olfactomedin 2 O95897 Secreted (Probable). Cell junction, synapse (By similarity). secreted 26 0 secreted secreted Deuterostomia Deuterostomia Bilateria OLFM3 HGNC:17990 olfactomedin 3 Q96PB7 Secreted (By similarity). Cell junction, synapse (By similarity). Golgi apparatus (GO:0005794) 12019210 secreted 23 0 golgi apparatus golgi apparatus Deuterostomia Deuterostomia Bilateria OLFM4 HGNC:17190 olfactomedin 4 Q6UX06 Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). Extracellular (GO:0005576) 11867215 secreted 33 0 mitochondrion. secreted multiple Mammalia Mammalia Bilateria OLFML1 HGNC:24473 olfactomedin-like 1 Q6UWY5 Secreted. secreted 100 0 secreted secreted Tetrapoda Euteleostomi Bilateria OLFML2A HGNC:27270 olfactomedin-like 2A Q68BL7 Secreted (By similarity). secreted 81 0 secreted secreted Euteleostomi Euteleostomi Bilateria OLFML2B HGNC:24558 olfactomedin-like 2B Q68BL8 Secreted (By similarity). Extracellular (GO:0005576) secreted 81 0 secreted secreted Chordata Chordata Bilateria OLFML3 HGNC:24956 olfactomedin-like 3 Q9NRN5 Secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 15280020,15280020 secreted 100 0 endoplasmic reticulum. secreted multiple Euteleostomi Euteleostomi Bilateria OLIG1 HGNC:16983 oligodendrocyte transcription factor 1 Q8TAK6 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15604411,15604411 nucleus 42 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eumetazoa OLIG2 HGNC:9398 oligodendrocyte lineage transcription factor 2 Q13516 Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity). Nucleus (GO:0005634) nucleus 58 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa OLIG3 HGNC:18003 oligodendrocyte transcription factor 3 Q7RTU3 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 98 0 nucleus nucleus Mammalia Euteleostomi Metazoa OLR1 HGNC:8133 oxidized low density lipoprotein (lectin-like) receptor 1 P78380 Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists. Plasma membrane (GO:0005886) 9052782 plasma membrane 17 1 plasma membrane. secreted multiple Eutheria Mammalia Eukaryota OMA1 HGNC:29661 OMA1 zinc metallopeptidase Q96E52 Mitochondrion inner membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783) 12886954 mitochondrion 47 2 endoplasmic reticulum. mitochondrion membrane multiple Deuterostomia Cell.Organisms Cell.Organisms OMD HGNC:8134 osteomodulin Q99983 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 14673660 secreted 32 0 secreted secreted Eutheria Eukaryota Cell.Organisms OMG HGNC:8135 oligodendrocyte myelin glycoprotein P23515 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 8244377 secreted 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms OMP HGNC:8136 olfactory marker protein P47874 Cytoplasm. Cytoplasm (GO:0005737) 12054873,8790421 cytoplasm 100 0 cytoplasm cytoplasm NA NA NA ONECUT1 HGNC:8138 one cut homeobox 1 Q9UBC0 Nucleus. Nucleus (GO:0005634) 8790352 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eumetazoa ONECUT2 HGNC:8139 one cut homeobox 2 O95948 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Mammalia Bilateria Eumetazoa ONECUT3 HGNC:13399 one cut homeobox 3 O60422 Nucleus (By similarity). nucleus 87 0 nucleus nucleus Human Human Eumetazoa OOEP HGNC:21382 oocyte expressed protein A6NGQ2 Cytoplasm (By similarity). Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). cytoplasm 43 0 cytoplasm cytoplasm Eutheria Eutheria Eutheria OOSP2 HGNC:26699 oocyte secreted protein 2 Q86WS3 Secreted (Potential). secreted 72 0 secreted secreted Euarchontoglires Euarchontoglires Eutheria OPA1 HGNC:8140 optic atrophy 1 (autosomal dominant) O60313 Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Mitochondrion (GO:0005739) 12123827,15598749 cytoplasm 11 0 mitochondrion. mitochondrion membrane multiple Bilateria Bilateria Eukaryota OPA3 HGNC:8142 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) Q9H6K4 Mitochondrion (Probable). Mitochondrion (GO:0005739) 11668429 cytoplasm 41 1 mitochondrion mitochondrion Theria Eukaryota Eukaryota OPALIN HGNC:20707 oligodendrocytic myelin paranodal and inner loop protein Q96PE5 Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS (By similarity). Integral to membrane (GO:0016021) 11814680 plasma membrane 100 1 plasma membrane plasma membrane Theria Theria Mammalia OPCML HGNC:8143 opioid binding protein/cell adhesion molecule-like Q14982 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886) 1333602 secreted 15 0 secreted secreted Amniota Bilateria Cell.Organisms OPHN1 HGNC:8148 oligophrenin 1 O60890 Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Note=Present in both presynaptic and postsynaptic sites (By similarity). Cytoplasm (GO:0005737) 11998687 cytoplasm 12 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota OPLAH HGNC:8149 5-oxoprolinase (ATP-hydrolysing) O14841 Cytoplasm (GO:0005737) 14993790 cytoplasm 39 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA OPN1LW HGNC:9936 opsin 1 (cone pigments), long-wave-sensitive P04000 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9860863 plasma membrane 4 7 plasma membrane plasma membrane Euteleostomi Euteleostomi NA OPN1MW HGNC:4206 opsin 1 (cone pigments), medium-wave-sensitive P04001 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9494086 plasma membrane 7 7 plasma membrane plasma membrane Euteleostomi Euteleostomi NA OPN1MW2 HGNC:26952 opsin 1 (cone pigments), medium-wave-sensitive 2 P04001 Membrane; Multi-pass membrane protein. plasma membrane 7 7 plasma membrane plasma membrane Euteleostomi Euteleostomi NA OPN1SW HGNC:1012 opsin 1 (cone pigments), short-wave-sensitive P03999 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9089077 plasma membrane 5 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Metazoa OPN3 HGNC:14007 opsin 3 Q9H1Y3 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11401433,10234000 plasma membrane 8 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa OPN4 HGNC:14449 opsin 4 Q9UHM6 Cell membrane; Multi-pass membrane protein (By similarity). Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells (By similarity). Plasma membrane (GO:0005886) 12163844 plasma membrane 72 7 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa OPN5 HGNC:19992 opsin 5 Q6U736 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14623103 plasma membrane 5 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa OPRD1 HGNC:8153 opioid receptor, delta 1 P41143 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Dense-core vesicle (None); Cytoplasm (GO:0005737); Vesicular fraction (GO:0042598) 11076532,16122428,16122428,16122428 plasma membrane 100 7 cytoplasm. plasma membrane multiple Theria Euteleostomi Eumetazoa OPRK1 HGNC:8154 opioid receptor, kappa 1 P41145 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Metazoa OPRL1 HGNC:8155 opiate receptor-like 1 P41146 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 8137918 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa OPRM1 HGNC:8156 opioid receptor, mu 1 P35372 Cell membrane; Multi-pass membrane protein. Isoform 12: Cytoplasm. Cell surface (GO:0009986); Endosome (GO:0005768); Plasma membrane (GO:0005886) 12810704,12810704,11076532,12810704 plasma membrane 98 7 cytoplasm. endosome. plasma membrane multiple Euteleostomi Euteleostomi Metazoa OPTC HGNC:8158 opticin Q9UBM4 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10636917 secreted 41 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms OPTN HGNC:17142 optineurin Q96CV9 Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Cytoplasm (GO:0005737);Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983/11137014,9488477,11137014,10756201,15561729 cytoplasm 14 0 cytoplasm. golgi apparatus. nucleus multiple Euteleostomi Deuterostomia Eumetazoa OR10A2 HGNC:8161 olfactory receptor, family 10, subfamily A, member 2 Q9H208 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Human Human Eumetazoa OR10A3 HGNC:8162 olfactory receptor, family 10, subfamily A, member 3 P58181 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Mammalia Eumetazoa OR10A4 HGNC:15130 olfactory receptor, family 10, subfamily A, member 4 Q9H209 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10A5 HGNC:15131 olfactory receptor, family 10, subfamily A, member 5 Q9H207 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10A6 HGNC:15132 olfactory receptor, family 10, subfamily A, member 6 Q8NH74 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Mammalia Eumetazoa OR10A7 HGNC:15329 olfactory receptor, family 10, subfamily A, member 7 Q8NGE5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10AD1 HGNC:14819 olfactory receptor, family 10, subfamily AD, member 1 Q8NGE0 Cell membrane; Multi-pass membrane protein. plasma membrane 31 7 plasma membrane plasma membrane Human Eutheria Eumetazoa OR10AG1 HGNC:19607 olfactory receptor, family 10, subfamily AG, member 1 Q8NH19 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 36 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa OR10C1 HGNC:8165 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) Q96KK4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria NA OR10G2 HGNC:8170 olfactory receptor, family 10, subfamily G, member 2 Q8NGC3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Bilateria OR10G3 HGNC:8171 olfactory receptor, family 10, subfamily G, member 3 Q8NGC4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14983052 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10G4 HGNC:14809 olfactory receptor, family 10, subfamily G, member 4 Q8NGN3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR10G7 HGNC:14842 olfactory receptor, family 10, subfamily G, member 7 Q8NGN6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10G8 HGNC:14845 olfactory receptor, family 10, subfamily G, member 8 Q8NGN5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR10G9 HGNC:15129 olfactory receptor, family 10, subfamily G, member 9 Q8NGN4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR10H1 HGNC:8172 olfactory receptor, family 10, subfamily H, member 1 Q9Y4A9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10H2 HGNC:8173 olfactory receptor, family 10, subfamily H, member 2 O60403 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 34 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10H3 HGNC:8174 olfactory receptor, family 10, subfamily H, member 3 O60404 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane Eutheria Eutheria Bilateria OR10H4 HGNC:15388 olfactory receptor, family 10, subfamily H, member 4 Q8NGA5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 31 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR10H5 HGNC:15389 olfactory receptor, family 10, subfamily H, member 5 Q8NGA6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Bilateria OR10J1 HGNC:8175 olfactory receptor, family 10, subfamily J, member 1 P30954 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10J3 HGNC:14992 olfactory receptor, family 10, subfamily J, member 3 Q5JRS4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 31 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10J4 HGNC:15408 olfactory receptor, family 10, subfamily J, member 4 (gene/pseudogene) P0C629 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR10J5 HGNC:14993 olfactory receptor, family 10, subfamily J, member 5 Q8NHC4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 34 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR10K1 HGNC:14693 olfactory receptor, family 10, subfamily K, member 1 Q8NGX5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 40 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10K2 HGNC:14826 olfactory receptor, family 10, subfamily K, member 2 Q6IF99 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 38 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10P1 HGNC:15378 olfactory receptor, family 10, subfamily P, member 1 Q8NGE3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10Q1 HGNC:15134 olfactory receptor, family 10, subfamily Q, member 1 Q8NGQ4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10R2 HGNC:14820 olfactory receptor, family 10, subfamily R, member 2 Q8NGX6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Theria Theria Eumetazoa OR10S1 HGNC:14807 olfactory receptor, family 10, subfamily S, member 1 Q8NGN2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR10T2 HGNC:14816 olfactory receptor, family 10, subfamily T, member 2 Q8NGX3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 36 7 plasma membrane plasma membrane Homininae Theria Bilateria OR10V1 HGNC:15136 olfactory receptor, family 10, subfamily V, member 1 Q8NGI7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 34 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR10W1 HGNC:15139 olfactory receptor, family 10, subfamily W, member 1 Q8NGF6 Cell membrane; Multi-pass membrane protein. plasma membrane 32 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10X1 HGNC:14995 olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene) Q8NGY0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 37 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR10Z1 HGNC:14996 olfactory receptor, family 10, subfamily Z, member 1 Q8NGY1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 35 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR11A1 HGNC:8176 olfactory receptor, family 11, subfamily A, member 1 Q9GZK7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14983052 plasma membrane 31 7 plasma membrane plasma membrane Theria Tetrapoda NA OR11G2 HGNC:15346 olfactory receptor, family 11, subfamily G, member 2 Q8NGC1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR11H1 HGNC:15404 olfactory receptor, family 11, subfamily H, member 1 Q8NG94 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR11H12 HGNC:30738 olfactory receptor, family 11, subfamily H, member 12 B2RN74 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 33 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR11H2 HGNC:14716 olfactory receptor, family 11, subfamily H, member 2 Q8NH07 Cell membrane; Multi-pass membrane protein (Potential). plasma membrane 33 7 plasma membrane plasma membrane NA NA NA OR11H4 HGNC:15347 olfactory receptor, family 11, subfamily H, member 4 Q8NGC9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 34 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR11H6 HGNC:15349 olfactory receptor, family 11, subfamily H, member 6 Q8NGC7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR11H7 HGNC:15350 olfactory receptor, family 11, subfamily H, member 7 (gene/pseudogene) Q8NGC8 Cell membrane; Multi-pass membrane protein. plasma membrane 34 7 plasma membrane plasma membrane NA NA Eumetazoa OR11L1 HGNC:14998 olfactory receptor, family 11, subfamily L, member 1 Q8NGX0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR12D2 HGNC:8178 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) P58182 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 33 7 plasma membrane plasma membrane Tetrapoda Tetrapoda NA OR12D3 HGNC:13963 olfactory receptor, family 12, subfamily D, member 3 Q9UGF7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Tetrapoda NA OR13A1 HGNC:14772 olfactory receptor, family 13, subfamily A, member 1 Q8NGR1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR13C2 HGNC:14701 olfactory receptor, family 13, subfamily C, member 2 Q8NGS9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR13C3 HGNC:14704 olfactory receptor, family 13, subfamily C, member 3 Q8NGS6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Bilateria OR13C4 HGNC:14722 olfactory receptor, family 13, subfamily C, member 4 Q8NGS5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR13C5 HGNC:15100 olfactory receptor, family 13, subfamily C, member 5 Q8NGS8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR13C8 HGNC:15103 olfactory receptor, family 13, subfamily C, member 8 Q8NGS7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR13C9 HGNC:15104 olfactory receptor, family 13, subfamily C, member 9 Q8NGT0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Human Eumetazoa OR13D1 HGNC:14695 olfactory receptor, family 13, subfamily D, member 1 Q8NGV5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR13F1 HGNC:14723 olfactory receptor, family 13, subfamily F, member 1 Q8NGS4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 48 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR13G1 HGNC:14999 olfactory receptor, family 13, subfamily G, member 1 Q8NGZ3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR13H1 HGNC:14755 olfactory receptor, family 13, subfamily H, member 1 Q8NG92 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1840504 plasma membrane 34 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR13J1 HGNC:15108 olfactory receptor, family 13, subfamily J, member 1 Q8NGT2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 40 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR14A16 HGNC:15022 olfactory receptor, family 14, subfamily A, member 16 Q8NHC5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane Human Mammalia Eumetazoa OR14C36 HGNC:15026 olfactory receptor, family 14, subfamily C, member 36 Q8NHC7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane Human Theria Eumetazoa OR14I1 HGNC:19575 olfactory receptor, family 14, subfamily I, member 1 A6ND48 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane Catarrhini Theria Eumetazoa OR14J1 HGNC:13971 olfactory receptor, family 14, subfamily J, member 1 Q9UGF5 Cell membrane; Multi-pass membrane protein. plasma membrane 30 7 plasma membrane plasma membrane Amniota Amniota NA OR14K1 HGNC:15025 olfactory receptor, family 14, subfamily K, member 1 Q8NGZ2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 27 7 plasma membrane plasma membrane Catarrhini Catarrhini Eumetazoa OR1A1 HGNC:8179 olfactory receptor, family 1, subfamily A, member 1 Q9P1Q5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR1A2 HGNC:8180 olfactory receptor, family 1, subfamily A, member 2 Q9Y585 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Human Eumetazoa OR1B1 HGNC:8181 olfactory receptor, family 1, subfamily B, member 1 Q8NGR6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Euarchontoglires Theria Eumetazoa OR1C1 HGNC:8182 olfactory receptor, family 1, subfamily C, member 1 Q15619 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR1D2 HGNC:8183 olfactory receptor, family 1, subfamily D, member 2 P34982 Cell membrane; Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal. Plasma membrane (GO:0005886) 8665947 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR1D4 HGNC:8185 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) P47884 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR1D5 HGNC:8186 olfactory receptor, family 1, subfamily D, member 5 P58170 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR1E1 HGNC:8189 olfactory receptor, family 1, subfamily E, member 1 P30953 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Euteleostomi Eumetazoa OR1E2 HGNC:8190 olfactory receptor, family 1, subfamily E, member 2 P47887 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 804088 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Euteleostomi Eumetazoa OR1E3 HGNC:8191 olfactory receptor, family 1, subfamily E, member 3 (gene/pseudogene) Q8WZA6 Cell membrane; Multi-pass membrane protein. plasma membrane 100 8 plasma membrane plasma membrane NA NA NA OR1F1 HGNC:8194 olfactory receptor, family 1, subfamily F, member 1 O43749 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR1F12 HGNC:13964 olfactory receptor, family 1, subfamily F, member 12 Q8NHA8 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR1G1 HGNC:8204 olfactory receptor, family 1, subfamily G, member 1 P47890 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12379593 plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR1I1 HGNC:8207 olfactory receptor, family 1, subfamily I, member 1 O60431 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Bilateria OR1J1 HGNC:8208 olfactory receptor, family 1, subfamily J, member 1 Q8NGS3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR1J2 HGNC:8209 olfactory receptor, family 1, subfamily J, member 2 Q8NGS2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Bilateria OR1J4 HGNC:8211 olfactory receptor, family 1, subfamily J, member 4 Q8NGS1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Bilateria OR1K1 HGNC:8212 olfactory receptor, family 1, subfamily K, member 1 Q8NGR3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR1L1 HGNC:8213 olfactory receptor, family 1, subfamily L, member 1 Q8NH94 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR1L3 HGNC:8215 olfactory receptor, family 1, subfamily L, member 3 Q8NH93 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Human Eumetazoa OR1L4 HGNC:8216 olfactory receptor, family 1, subfamily L, member 4 Q8NGR5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa OR1L6 HGNC:8218 olfactory receptor, family 1, subfamily L, member 6 Q8NGR2 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR1L8 HGNC:15110 olfactory receptor, family 1, subfamily L, member 8 Q8NGR8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR1M1 HGNC:8220 olfactory receptor, family 1, subfamily M, member 1 Q8NGA1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR1N1 HGNC:8221 olfactory receptor, family 1, subfamily N, member 1 Q8NGS0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR1N2 HGNC:15111 olfactory receptor, family 1, subfamily N, member 2 Q8NGR9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR1P1 HGNC:8222 olfactory receptor, family 1, subfamily P, member 1 (gene/pseudogene) Q8NH06 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR1Q1 HGNC:8223 olfactory receptor, family 1, subfamily Q, member 1 Q15612 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 41 7 plasma membrane plasma membrane Euarchontoglires Theria Eumetazoa OR1S1 HGNC:8227 olfactory receptor, family 1, subfamily S, member 1 Q8NH92 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR1S2 HGNC:15141 olfactory receptor, family 1, subfamily S, member 2 Q8NGQ3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Human Eumetazoa OR2A1 HGNC:8229 olfactory receptor, family 2, subfamily A, member 1 Q8NGT9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2A12 HGNC:15082 olfactory receptor, family 2, subfamily A, member 12 Q8NGT7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2A14 HGNC:15084 olfactory receptor, family 2, subfamily A, member 14 Q96R47 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2A2 HGNC:8230 olfactory receptor, family 2, subfamily A, member 2 Q6IF42 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2A25 HGNC:19562 olfactory receptor, family 2, subfamily A, member 25 A4D2G3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2A4 HGNC:14729 olfactory receptor, family 2, subfamily A, member 4 O95047 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 77 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2A42 HGNC:31230 olfactory receptor, family 2, subfamily A, member 42 Q8NGT9 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2A5 HGNC:8232 olfactory receptor, family 2, subfamily A, member 5 Q96R48 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2A7 HGNC:8234 olfactory receptor, family 2, subfamily A, member 7 Q96R45 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 77 7 plasma membrane plasma membrane NA NA Eumetazoa OR2AE1 HGNC:15087 olfactory receptor, family 2, subfamily AE, member 1 Q8NHA4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2AG1 HGNC:15142 olfactory receptor, family 2, subfamily AG, member 1 Q9H205 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 35 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2AG2 HGNC:15143 olfactory receptor, family 2, subfamily AG, member 2 A6NM03 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 37 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2AK2 HGNC:19569 olfactory receptor, family 2, subfamily AK, member 2 Q8NG84 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2AP1 HGNC:15335 olfactory receptor, family 2, subfamily AP, member 1 Q8NGE2 Cell membrane; Multi-pass membrane protein. plasma membrane 32 7 plasma membrane plasma membrane Euarchontoglires Euarchontoglires Eumetazoa OR2AT4 HGNC:19620 olfactory receptor, family 2, subfamily AT, member 4 A6NND4 Cell membrane; Multi-pass membrane protein. plasma membrane 26 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2B11 HGNC:31249 olfactory receptor, family 2, subfamily B, member 11 Q5JQS5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2B2 HGNC:13966 olfactory receptor, family 2, subfamily B, member 2 Q9GZK3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR2B3 HGNC:8238 olfactory receptor, family 2, subfamily B, member 3 O76000 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia NA OR2B6 HGNC:8241 olfactory receptor, family 2, subfamily B, member 6 P58173 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR2C1 HGNC:8242 olfactory receptor, family 2, subfamily C, member 1 O95371 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR2C3 HGNC:15005 olfactory receptor, family 2, subfamily C, member 3 Q8N628 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR2D2 HGNC:8244 olfactory receptor, family 2, subfamily D, member 2 Q9H210 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR2D3 HGNC:15146 olfactory receptor, family 2, subfamily D, member 3 Q8NGH3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2F1 HGNC:8246 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) Q13607 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2F2 HGNC:8247 olfactory receptor, family 2, subfamily F, member 2 O95006 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2G2 HGNC:15007 olfactory receptor, family 2, subfamily G, member 2 Q8NGZ5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 56 7 plasma membrane plasma membrane Homininae Eutheria Bilateria OR2G3 HGNC:15008 olfactory receptor, family 2, subfamily G, member 3 Q8NGZ4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR2G6 HGNC:27019 olfactory receptor, family 2, subfamily G, member 6 Q5TZ20 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR2H1 HGNC:8252 olfactory receptor, family 2, subfamily H, member 1 Q9GZK4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Eutheria NA OR2H2 HGNC:8253 olfactory receptor, family 2, subfamily H, member 2 O95918 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria NA OR2J1 HGNC:8259 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene) Q9GZK6 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR2J2 HGNC:8260 olfactory receptor, family 2, subfamily J, member 2 O76002 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae NA OR2J3 HGNC:8261 olfactory receptor, family 2, subfamily J, member 3 O76001 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria NA OR2K2 HGNC:8264 olfactory receptor, family 2, subfamily K, member 2 Q8NGT1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2L13 HGNC:19578 olfactory receptor, family 2, subfamily L, member 13 Q8N349 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 40 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2L2 HGNC:8266 olfactory receptor, family 2, subfamily L, member 2 Q8NH16 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 88 7 plasma membrane plasma membrane Human Catarrhini Eumetazoa OR2L3 HGNC:15009 olfactory receptor, family 2, subfamily L, member 3 Q8NG85 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2L5 HGNC:15011 olfactory receptor, family 2, subfamily L, member 5 Q8NG80 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2L8 HGNC:15014 olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene) Q8NGY9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 84 7 plasma membrane plasma membrane Human Human Bilateria OR2M2 HGNC:8268 olfactory receptor, family 2, subfamily M, member 2 Q96R28 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2M3 HGNC:8269 olfactory receptor, family 2, subfamily M, member 3 Q8NG83 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 36 7 plasma membrane plasma membrane NA NA Eumetazoa OR2M4 HGNC:8270 olfactory receptor, family 2, subfamily M, member 4 Q96R27 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 31 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR2M5 HGNC:19576 olfactory receptor, family 2, subfamily M, member 5 A3KFT3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 36 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa OR2M7 HGNC:19594 olfactory receptor, family 2, subfamily M, member 7 Q8NG81 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 36 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa OR2S2 HGNC:8276 olfactory receptor, family 2, subfamily S, member 2 Q9NQN1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T1 HGNC:8277 olfactory receptor, family 2, subfamily T, member 1 O43869 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T10 HGNC:19573 olfactory receptor, family 2, subfamily T, member 10 Q8NGZ9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 39 7 plasma membrane plasma membrane Human Catarrhini Eumetazoa OR2T11 HGNC:19574 olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene) Q8NH01 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 56 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR2T12 HGNC:19592 olfactory receptor, family 2, subfamily T, member 12 Q8NG77 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2T2 HGNC:14725 olfactory receptor, family 2, subfamily T, member 2 Q6IF00 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T27 HGNC:31252 olfactory receptor, family 2, subfamily T, member 27 Q8NH04 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR2T29 HGNC:31253 olfactory receptor, family 2, subfamily T, member 29 Q8NH02 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 43 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T3 HGNC:14727 olfactory receptor, family 2, subfamily T, member 3 Q8NH03 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 46 7 plasma membrane plasma membrane Human Eutheria Eumetazoa OR2T33 HGNC:31255 olfactory receptor, family 2, subfamily T, member 33 Q8NG76 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR2T34 HGNC:31256 olfactory receptor, family 2, subfamily T, member 34 Q8NGX1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 45 7 plasma membrane plasma membrane Human Eutheria Metazoa OR2T35 HGNC:31257 olfactory receptor, family 2, subfamily T, member 35 Q8NGX2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T4 HGNC:15016 olfactory receptor, family 2, subfamily T, member 4 Q8NH00 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T5 HGNC:15017 olfactory receptor, family 2, subfamily T, member 5 Q6IEZ7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 43 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2T6 HGNC:15018 olfactory receptor, family 2, subfamily T, member 6 Q8NHC8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 56 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR2T7 HGNC:15019 olfactory receptor, family 2, subfamily T, member 7 P0C7T2 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR2T8 HGNC:15020 olfactory receptor, family 2, subfamily T, member 8 A6NH00 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR2V1 HGNC:8280 olfactory receptor, family 2, subfamily V, member 1 Q8NHB1 Cell membrane; Multi-pass membrane protein. plasma membrane 44 7 plasma membrane plasma membrane NA NA Eumetazoa OR2V2 HGNC:15341 olfactory receptor, family 2, subfamily V, member 2 Q96R30 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2W1 HGNC:8281 olfactory receptor, family 2, subfamily W, member 1 Q9Y3N9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria NA OR2W3 HGNC:15021 olfactory receptor, family 2, subfamily W, member 3 Q7Z3T1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR2Y1 HGNC:14837 olfactory receptor, family 2, subfamily Y, member 1 Q8NGV0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR2Z1 HGNC:15391 olfactory receptor, family 2, subfamily Z, member 1 Q8NG97 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 41 7 plasma membrane plasma membrane Eutheria Eutheria NA OR3A1 HGNC:8282 olfactory receptor, family 3, subfamily A, member 1 P47881 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR3A2 HGNC:8283 olfactory receptor, family 3, subfamily A, member 2 P47893 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR3A3 HGNC:8284 olfactory receptor, family 3, subfamily A, member 3 P47888 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Catarrhini Catarrhini Eumetazoa OR4A15 HGNC:15152 olfactory receptor, family 4, subfamily A, member 15 Q8NGL6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4A16 HGNC:15153 olfactory receptor, family 4, subfamily A, member 16 Q8NH70 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 52 7 plasma membrane plasma membrane Homininae Euarchontoglires Eumetazoa OR4A47 HGNC:31266 olfactory receptor, family 4, subfamily A, member 47 Q6IF82 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR4A5 HGNC:15162 olfactory receptor, family 4, subfamily A, member 5 Q8NH83 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR4B1 HGNC:8290 olfactory receptor, family 4, subfamily B, member 1 Q8NGF8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4C11 HGNC:15167 olfactory receptor, family 4, subfamily C, member 11 Q6IEV9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4C12 HGNC:15168 olfactory receptor, family 4, subfamily C, member 12 Q96R67 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR4C13 HGNC:15169 olfactory receptor, family 4, subfamily C, member 13 Q8NGP0 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR4C15 HGNC:15171 olfactory receptor, family 4, subfamily C, member 15 Q8NGM1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4C16 HGNC:15172 olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene) Q8NGL9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 59 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4C3 HGNC:14697 olfactory receptor, family 4, subfamily C, member 3 Q8NH37 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR4C45 HGNC:31270 olfactory receptor, family 4, subfamily C, member 45 A6NMZ5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 49 7 plasma membrane plasma membrane Eutheria Mammalia NA OR4C46 HGNC:31271 olfactory receptor, family 4, subfamily C, member 46 A6NHA9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4C5 HGNC:14702 olfactory receptor, family 4, subfamily C, member 5 Q8NGB2 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Homininae Euarchontoglires Bilateria OR4C6 HGNC:14743 olfactory receptor, family 4, subfamily C, member 6 Q8NH72 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4D1 HGNC:8293 olfactory receptor, family 4, subfamily D, member 1 Q15615 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4D10 HGNC:15173 olfactory receptor, family 4, subfamily D, member 10 Q8NGI6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 74 7 plasma membrane plasma membrane NA NA Eumetazoa OR4D11 HGNC:15174 olfactory receptor, family 4, subfamily D, member 11 Q8NGI4 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4D2 HGNC:8294 olfactory receptor, family 4, subfamily D, member 2 P58180 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 48 7 plasma membrane plasma membrane NA NA Eumetazoa OR4D5 HGNC:14852 olfactory receptor, family 4, subfamily D, member 5 Q8NGN0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4D6 HGNC:15175 olfactory receptor, family 4, subfamily D, member 6 Q8NGJ1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4D9 HGNC:15178 olfactory receptor, family 4, subfamily D, member 9 Q8NGE8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Catarrhini Eutheria Eumetazoa OR4E1 HGNC:8296 olfactory receptor, family 4, subfamily E, member 1 (gene/pseudogene) P0C645 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR4E2 HGNC:8297 olfactory receptor, family 4, subfamily E, member 2 Q8NGC2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR4F15 HGNC:15078 olfactory receptor, family 4, subfamily F, member 15 Q8NGB8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 45 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR4F16 HGNC:15079 olfactory receptor, family 4, subfamily F, member 16 Q6IEY1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 41 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR4F17 HGNC:15381 olfactory receptor, family 4, subfamily F, member 17 Q8NGA8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 50 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR4F21 HGNC:19583 olfactory receptor, family 4, subfamily F, member 21 O95013 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 42 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR4F29 HGNC:31275 olfactory receptor, family 4, subfamily F, member 29 Q6IEY1 Cell membrane; Multi-pass membrane protein. plasma membrane 41 7 plasma membrane plasma membrane NA NA Eumetazoa OR4F3 HGNC:8300 olfactory receptor, family 4, subfamily F, member 3 Q6IEY1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 41 7 plasma membrane plasma membrane NA NA Eumetazoa OR4F4 HGNC:8301 olfactory receptor, family 4, subfamily F, member 4 Q96R69 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 50 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR4F5 HGNC:14825 olfactory receptor, family 4, subfamily F, member 5 Q8NH21 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 50 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR4F6 HGNC:15372 olfactory receptor, family 4, subfamily F, member 6 Q8NGB9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14983052 plasma membrane 44 7 plasma membrane plasma membrane Euarchontoglires Euarchontoglires Eumetazoa OR4K1 HGNC:14726 olfactory receptor, family 4, subfamily K, member 1 Q8NGD4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4K13 HGNC:15351 olfactory receptor, family 4, subfamily K, member 13 Q8NH42 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 55 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4K14 HGNC:15352 olfactory receptor, family 4, subfamily K, member 14 Q8NGD5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa OR4K15 HGNC:15353 olfactory receptor, family 4, subfamily K, member 15 Q8NH41 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4K17 HGNC:15355 olfactory receptor, family 4, subfamily K, member 17 Q8NGC6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Catarrhini Catarrhini Eumetazoa OR4K2 HGNC:14728 olfactory receptor, family 4, subfamily K, member 2 Q8NGD2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 57 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4K3 HGNC:14731 olfactory receptor, family 4, subfamily K, member 3 (gene/pseudogene) Q96R72 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR4K5 HGNC:14745 olfactory receptor, family 4, subfamily K, member 5 Q8NGD3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 51 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR4L1 HGNC:15356 olfactory receptor, family 4, subfamily L, member 1 Q8NH43 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14983052 plasma membrane 50 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4M1 HGNC:14735 olfactory receptor, family 4, subfamily M, member 1 Q8NGD0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Eumetazoa OR4M2 HGNC:15373 olfactory receptor, family 4, subfamily M, member 2 Q8NGB6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 92 7 plasma membrane plasma membrane Human Human Eumetazoa OR4N2 HGNC:14742 olfactory receptor, family 4, subfamily N, member 2 Q8NGD1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 44 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa OR4N4 HGNC:15375 olfactory receptor, family 4, subfamily N, member 4 Q8N0Y3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 45 7 plasma membrane plasma membrane Human Catarrhini Bilateria OR4N5 HGNC:15358 olfactory receptor, family 4, subfamily N, member 5 Q8IXE1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 45 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR4P4 HGNC:15180 olfactory receptor, family 4, subfamily P, member 4 Q8NGL7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 50 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4Q2 HGNC:15359 olfactory receptor, family 4, subfamily Q, member 2 (gene/pseudogene) P0C623 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4Q3 HGNC:15426 olfactory receptor, family 4, subfamily Q, member 3 Q8NH05 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR4S1 HGNC:14705 olfactory receptor, family 4, subfamily S, member 1 Q8NGB4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR4S2 HGNC:15183 olfactory receptor, family 4, subfamily S, member 2 Q8NH73 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR4X1 HGNC:14854 olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene) Q8NH49 Cell membrane; Multi-pass membrane protein. plasma membrane 48 7 plasma membrane plasma membrane Human Eutheria Eumetazoa OR4X2 HGNC:15184 olfactory receptor, family 4, subfamily X, member 2 Q8NGF9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR51A2 HGNC:14764 olfactory receptor, family 51, subfamily A, member 2 Q8NGJ7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 13 7 plasma membrane plasma membrane Human Human Eumetazoa OR51A4 HGNC:14795 olfactory receptor, family 51, subfamily A, member 4 Q8NGJ6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Catarrhini Eutheria Eumetazoa OR51A7 HGNC:15188 olfactory receptor, family 51, subfamily A, member 7 Q8NH64 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 14 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51B2 HGNC:14703 olfactory receptor, family 51, subfamily B, member 2 Q9Y5P1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 17 7 plasma membrane plasma membrane Euarchontoglires Theria Bilateria OR51B4 HGNC:14708 olfactory receptor, family 51, subfamily B, member 4 Q9Y5P0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 15 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR51B5 HGNC:19599 olfactory receptor, family 51, subfamily B, member 5 Q9H339 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane NA NA Eumetazoa OR51B6 HGNC:19600 olfactory receptor, family 51, subfamily B, member 6 Q9H340 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 14 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51D1 HGNC:15193 olfactory receptor, family 51, subfamily D, member 1 Q8NGF3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 16 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51E1 HGNC:15194 olfactory receptor, family 51, subfamily E, member 1 Q8TCB6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15313197 plasma membrane 18 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR51E2 HGNC:15195 olfactory receptor, family 51, subfamily E, member 2 Q9H255 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 20 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa OR51F1 HGNC:15196 olfactory receptor, family 51, subfamily F, member 1 A6NGY5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Theria Theria Bilateria OR51F2 HGNC:15197 olfactory receptor, family 51, subfamily F, member 2 Q8NH61 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 17 7 plasma membrane plasma membrane Theria Theria Bilateria OR51G1 HGNC:14738 olfactory receptor, family 51, subfamily G, member 1 Q8NGK1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Eutheria Eutheria Bilateria OR51G2 HGNC:15198 olfactory receptor, family 51, subfamily G, member 2 Q8NGK0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR51I1 HGNC:15200 olfactory receptor, family 51, subfamily I, member 1 Q9H343 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 15 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51I2 HGNC:15201 olfactory receptor, family 51, subfamily I, member 2 Q9H344 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 18 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51J1 HGNC:14856 olfactory receptor, family 51, subfamily J, member 1 (gene/pseudogene) Q9H342 Cell membrane; Multi-pass membrane protein. plasma membrane 10 7 plasma membrane plasma membrane Human Mammalia Bilateria OR51L1 HGNC:14759 olfactory receptor, family 51, subfamily L, member 1 Q8NGJ5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 22 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR51M1 HGNC:14847 olfactory receptor, family 51, subfamily M, member 1 Q9H341 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 7 plasma membrane plasma membrane Catarrhini Eutheria Eumetazoa OR51Q1 HGNC:14851 olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene) Q8NH59 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 11 7 plasma membrane plasma membrane Theria Theria Bilateria OR51S1 HGNC:15204 olfactory receptor, family 51, subfamily S, member 1 Q8NGJ8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 15 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51T1 HGNC:15205 olfactory receptor, family 51, subfamily T, member 1 Q8NGJ9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR51V1 HGNC:19597 olfactory receptor, family 51, subfamily V, member 1 Q9H2C8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 14 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR52A1 HGNC:8318 olfactory receptor, family 52, subfamily A, member 1 Q9UKL2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 14 7 plasma membrane plasma membrane Catarrhini Eutheria Eumetazoa OR52A5 HGNC:19580 olfactory receptor, family 52, subfamily A, member 5 Q9H2C5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 15 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR52B2 HGNC:15207 olfactory receptor, family 52, subfamily B, member 2 Q96RD2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14983052 plasma membrane 18 7 plasma membrane plasma membrane NA NA Eumetazoa OR52B4 HGNC:15209 olfactory receptor, family 52, subfamily B, member 4 Q8NGK2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane NA NA Eumetazoa OR52B6 HGNC:15211 olfactory receptor, family 52, subfamily B, member 6 Q8NGF0 Cell membrane; Multi-pass membrane protein. plasma membrane 20 7 plasma membrane plasma membrane Human Theria Eumetazoa OR52D1 HGNC:15212 olfactory receptor, family 52, subfamily D, member 1 Q9H346 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR52E1 HGNC:14766 olfactory receptor, family 52, subfamily E, member 1 (gene/pseudogene) Q8NGJ3 Cell membrane; Multi-pass membrane protein. plasma membrane 20 7 plasma membrane plasma membrane NA NA NA OR52E2 HGNC:14769 olfactory receptor, family 52, subfamily E, member 2 Q8NGJ4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14983052 plasma membrane 18 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR52E4 HGNC:15213 olfactory receptor, family 52, subfamily E, member 4 Q8NGH9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 19 7 plasma membrane plasma membrane Human Mammalia Eumetazoa OR52E5 HGNC:15214 olfactory receptor, family 52, subfamily E, member 5 Q8NH55 Cell membrane; Multi-pass membrane protein. plasma membrane 17 7 plasma membrane plasma membrane NA NA NA OR52E6 HGNC:15215 olfactory receptor, family 52, subfamily E, member 6 Q96RD3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa OR52E8 HGNC:15217 olfactory receptor, family 52, subfamily E, member 8 Q6IFG1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 21 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR52H1 HGNC:15218 olfactory receptor, family 52, subfamily H, member 1 Q8NGJ2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 18 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR52I1 HGNC:15220 olfactory receptor, family 52, subfamily I, member 1 Q8NGK6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 17 7 plasma membrane plasma membrane NA NA Eumetazoa OR52I2 HGNC:15221 olfactory receptor, family 52, subfamily I, member 2 Q8NH67 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 7 plasma membrane plasma membrane NA NA Eumetazoa OR52J3 HGNC:14799 olfactory receptor, family 52, subfamily J, member 3 Q8NH60 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR52K1 HGNC:15222 olfactory receptor, family 52, subfamily K, member 1 Q8NGK4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 18 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR52K2 HGNC:15223 olfactory receptor, family 52, subfamily K, member 2 Q8NGK3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane Theria Theria Bilateria OR52L1 HGNC:14785 olfactory receptor, family 52, subfamily L, member 1 Q8NGH7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 21 7 plasma membrane plasma membrane Theria Theria Bilateria OR52M1 HGNC:15225 olfactory receptor, family 52, subfamily M, member 1 Q8NGK5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Theria Tetrapoda Eumetazoa OR52N1 HGNC:14853 olfactory receptor, family 52, subfamily N, member 1 Q8NH53 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Eutheria Eutheria Bilateria OR52N2 HGNC:15228 olfactory receptor, family 52, subfamily N, member 2 Q8NGI0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 16 7 plasma membrane plasma membrane Mammalia Tetrapoda Eumetazoa OR52N4 HGNC:15230 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) Q8NGI2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 15 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR52N5 HGNC:15231 olfactory receptor, family 52, subfamily N, member 5 Q8NH56 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 15 7 plasma membrane plasma membrane Theria Theria Bilateria OR52R1 HGNC:15235 olfactory receptor, family 52, subfamily R, member 1 Q8NGF1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 19 7 plasma membrane plasma membrane Theria Amniota Bilateria OR52W1 HGNC:15239 olfactory receptor, family 52, subfamily W, member 1 Q6IF63 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 16 7 plasma membrane plasma membrane Theria Theria Bilateria OR52Z1 HGNC:19596 olfactory receptor, family 52, subfamily Z, member 1 (gene/pseudogene) P0C646 Cell membrane; Multi-pass membrane protein. plasma membrane 20 7 plasma membrane plasma membrane Human Theria NA OR56A1 HGNC:14781 olfactory receptor, family 56, subfamily A, member 1 Q8NGH5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 17 7 plasma membrane plasma membrane Mammalia Mammalia Bilateria OR56A3 HGNC:14786 olfactory receptor, family 56, subfamily A, member 3 Q8NH54 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 7 plasma membrane plasma membrane Human Theria Eumetazoa OR56A4 HGNC:14791 olfactory receptor, family 56, subfamily A, member 4 Q8NGH8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane Mammalia Mammalia Bilateria OR56A5 HGNC:14792 olfactory receptor, family 56, subfamily A, member 5 P0C7T3 Cell membrane; Multi-pass membrane protein. plasma membrane 17 7 plasma membrane plasma membrane NA NA NA OR56B1 HGNC:15245 olfactory receptor, family 56, subfamily B, member 1 Q8NGI3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 7 plasma membrane plasma membrane Mammalia Mammalia Bilateria OR56B4 HGNC:15248 olfactory receptor, family 56, subfamily B, member 4 Q8NH76 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Theria Theria Bilateria OR5A1 HGNC:8319 olfactory receptor, family 5, subfamily A, member 1 Q8NGJ0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14983052 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR5A2 HGNC:15249 olfactory receptor, family 5, subfamily A, member 2 Q8NGI9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR5AC1 HGNC:15047 olfactory receptor, family 5, subfamily AC, member 1 (gene/pseudogene) P0C628 Cell membrane; Multi-pass membrane protein. plasma membrane 40 7 plasma membrane plasma membrane NA NA NA OR5AC2 HGNC:15431 olfactory receptor, family 5, subfamily AC, member 2 Q9NZP5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 39 7 plasma membrane plasma membrane Human Theria Eumetazoa OR5AK2 HGNC:15251 olfactory receptor, family 5, subfamily AK, member 2 Q8NH90 Cell membrane; Multi-pass membrane protein. plasma membrane 40 7 plasma membrane plasma membrane Theria Amniota Eumetazoa OR5AL1 HGNC:14844 olfactory receptor, family 5, subfamily AL, member 1 (gene/pseudogene) P0C617 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR5AN1 HGNC:15255 olfactory receptor, family 5, subfamily AN, member 1 Q8NGI8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR5AP2 HGNC:15258 olfactory receptor, family 5, subfamily AP, member 2 Q8NGF4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5AR1 HGNC:15260 olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene) Q8NGP9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Amniota Amniota Eumetazoa OR5AS1 HGNC:15261 olfactory receptor, family 5, subfamily AS, member 1 Q8N127 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Bilateria OR5AU1 HGNC:15362 olfactory receptor, family 5, subfamily AU, member 1 Q8NGC0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 8 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR5B12 HGNC:15432 olfactory receptor, family 5, subfamily B, member 12 Q96R08 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14983052 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5B17 HGNC:15267 olfactory receptor, family 5, subfamily B, member 17 Q8NGF7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5B2 HGNC:8323 olfactory receptor, family 5, subfamily B, member 2 Q96R09 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR5B21 HGNC:19616 olfactory receptor, family 5, subfamily B, member 21 A6NL26 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Theria Eumetazoa OR5B3 HGNC:8324 olfactory receptor, family 5, subfamily B, member 3 Q8NH48 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5C1 HGNC:8331 olfactory receptor, family 5, subfamily C, member 1 Q8NGR4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5D13 HGNC:15280 olfactory receptor, family 5, subfamily D, member 13 Q8NGL4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 40 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5D14 HGNC:15281 olfactory receptor, family 5, subfamily D, member 14 Q8NGL3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 46 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5D16 HGNC:15283 olfactory receptor, family 5, subfamily D, member 16 Q8NGK9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 47 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5D18 HGNC:15285 olfactory receptor, family 5, subfamily D, member 18 Q8NGL1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Bilateria OR5F1 HGNC:8343 olfactory receptor, family 5, subfamily F, member 1 O95221 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5G3 HGNC:15287 olfactory receptor, family 5, subfamily G, member 3 (gene/pseudogene) P0C626 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR5H1 HGNC:8346 olfactory receptor, family 5, subfamily H, member 1 A6NKK0 Cell membrane; Multi-pass membrane protein. plasma membrane 39 7 plasma membrane plasma membrane NA NA Eumetazoa OR5H14 HGNC:31286 olfactory receptor, family 5, subfamily H, member 14 A6NHG9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 40 7 plasma membrane plasma membrane NA NA Eumetazoa OR5H15 HGNC:31287 olfactory receptor, family 5, subfamily H, member 15 A6NDH6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 37 7 plasma membrane plasma membrane NA NA Eumetazoa OR5H2 HGNC:14752 olfactory receptor, family 5, subfamily H, member 2 Q8NGV7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5H6 HGNC:14767 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) Q8NGV6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 37 7 plasma membrane plasma membrane NA NA Eumetazoa OR5I1 HGNC:8347 olfactory receptor, family 5, subfamily I, member 1 Q13606 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Bilateria OR5J2 HGNC:19612 olfactory receptor, family 5, subfamily J, member 2 Q8NH18 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 73 7 plasma membrane plasma membrane Amniota Amniota Eumetazoa OR5K1 HGNC:8349 olfactory receptor, family 5, subfamily K, member 1 Q8NHB7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR5K2 HGNC:14774 olfactory receptor, family 5, subfamily K, member 2 Q8NHB8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 93 7 plasma membrane plasma membrane NA NA Eumetazoa OR5K3 HGNC:31290 olfactory receptor, family 5, subfamily K, member 3 A6NET4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Theria Eumetazoa OR5K4 HGNC:31291 olfactory receptor, family 5, subfamily K, member 4 A6NMS3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa OR5L1 HGNC:8350 olfactory receptor, family 5, subfamily L, member 1 Q8NGL2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5L2 HGNC:8351 olfactory receptor, family 5, subfamily L, member 2 Q8NGL0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5M1 HGNC:8352 olfactory receptor, family 5, subfamily M, member 1 Q8NGP8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR5M10 HGNC:15290 olfactory receptor, family 5, subfamily M, member 10 Q6IEU7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR5M11 HGNC:15291 olfactory receptor, family 5, subfamily M, member 11 Q96RB7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR5M3 HGNC:14806 olfactory receptor, family 5, subfamily M, member 3 Q8NGP4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5M8 HGNC:14846 olfactory receptor, family 5, subfamily M, member 8 Q8NGP6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR5M9 HGNC:15294 olfactory receptor, family 5, subfamily M, member 9 Q8NGP3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Bilateria OR5P2 HGNC:14783 olfactory receptor, family 5, subfamily P, member 2 Q8WZ92 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11705801 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Bilateria OR5P3 HGNC:14784 olfactory receptor, family 5, subfamily P, member 3 Q8WZ94 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11705801 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR5R1 HGNC:14841 olfactory receptor, family 5, subfamily R, member 1 Q8NH85 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR5T1 HGNC:14821 olfactory receptor, family 5, subfamily T, member 1 Q8NG75 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia NA OR5T2 HGNC:15296 olfactory receptor, family 5, subfamily T, member 2 Q8NGG2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria NA OR5T3 HGNC:15297 olfactory receptor, family 5, subfamily T, member 3 Q8NGG3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia NA OR5V1 HGNC:13972 olfactory receptor, family 5, subfamily V, member 1 Q9UGF6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Tetrapoda NA OR5W2 HGNC:15299 olfactory receptor, family 5, subfamily W, member 2 Q8NH69 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6A2 HGNC:15301 olfactory receptor, family 6, subfamily A, member 2 O95222 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6B1 HGNC:8354 olfactory receptor, family 6, subfamily B, member 1 O95007 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR6B2 HGNC:15041 olfactory receptor, family 6, subfamily B, member 2 Q6IFH4 Cell membrane; Multi-pass membrane protein. plasma membrane 46 7 plasma membrane plasma membrane Theria Theria Bilateria OR6B3 HGNC:15042 olfactory receptor, family 6, subfamily B, member 3 Q8NGW1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6C1 HGNC:8355 olfactory receptor, family 6, subfamily C, member 1 Q96RD1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 33 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6C2 HGNC:15436 olfactory receptor, family 6, subfamily C, member 2 Q9NZP2 Cell membrane; Multi-pass membrane protein. plasma membrane 30 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6C3 HGNC:15437 olfactory receptor, family 6, subfamily C, member 3 Q9NZP0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Human Eutheria Eumetazoa OR6C4 HGNC:19632 olfactory receptor, family 6, subfamily C, member 4 Q8NGE1 Cell membrane; Multi-pass membrane protein. plasma membrane 34 7 plasma membrane plasma membrane Mammalia Tetrapoda Eumetazoa OR6C6 HGNC:31293 olfactory receptor, family 6, subfamily C, member 6 A6NF89 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6C65 HGNC:31295 olfactory receptor, family 6, subfamily C, member 65 A6NJZ3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 31 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR6C68 HGNC:31297 olfactory receptor, family 6, subfamily C, member 68 A6NDL8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 29 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR6C70 HGNC:31299 olfactory receptor, family 6, subfamily C, member 70 A6NIJ9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Human Euarchontoglires Eumetazoa OR6C74 HGNC:31303 olfactory receptor, family 6, subfamily C, member 74 A6NCV1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6C75 HGNC:31304 olfactory receptor, family 6, subfamily C, member 75 A6NL08 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR6C76 HGNC:31305 olfactory receptor, family 6, subfamily C, member 76 A6NM76 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR6F1 HGNC:15027 olfactory receptor, family 6, subfamily F, member 1 Q8NGZ6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 40 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6J1 HGNC:14707 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) Q8NGC5 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR6K2 HGNC:15029 olfactory receptor, family 6, subfamily K, member 2 Q8NGY2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 40 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6K3 HGNC:15030 olfactory receptor, family 6, subfamily K, member 3 Q8NGY3 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6K6 HGNC:15033 olfactory receptor, family 6, subfamily K, member 6 Q8NGW6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Bilateria OR6M1 HGNC:14711 olfactory receptor, family 6, subfamily M, member 1 Q8NGM8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 33 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6N1 HGNC:15034 olfactory receptor, family 6, subfamily N, member 1 Q8NGY5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6N2 HGNC:15035 olfactory receptor, family 6, subfamily N, member 2 Q8NGY6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Euarchontoglires Eumetazoa OR6P1 HGNC:15036 olfactory receptor, family 6, subfamily P, member 1 Q8NGX9 Cell membrane; Multi-pass membrane protein. plasma membrane 47 7 plasma membrane plasma membrane Theria Theria Bilateria OR6Q1 HGNC:15302 olfactory receptor, family 6, subfamily Q, member 1 Q8NGQ2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR6S1 HGNC:15363 olfactory receptor, family 6, subfamily S, member 1 Q8NH40 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR6T1 HGNC:14848 olfactory receptor, family 6, subfamily T, member 1 Q8NGN1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane Human Theria Eumetazoa OR6V1 HGNC:15090 olfactory receptor, family 6, subfamily V, member 1 Q8N148 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 29 7 plasma membrane plasma membrane NA NA NA OR6X1 HGNC:14737 olfactory receptor, family 6, subfamily X, member 1 Q8NH79 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 7 plasma membrane plasma membrane NA NA Eumetazoa OR6Y1 HGNC:14823 olfactory receptor, family 6, subfamily Y, member 1 Q8NGX8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR7A10 HGNC:8356 olfactory receptor, family 7, subfamily A, member 10 O76100 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR7A17 HGNC:8363 olfactory receptor, family 7, subfamily A, member 17 O14581 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR7A5 HGNC:8368 olfactory receptor, family 7, subfamily A, member 5 Q15622 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 9119360 plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa OR7C1 HGNC:8373 olfactory receptor, family 7, subfamily C, member 1 O76099 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR7C2 HGNC:8374 olfactory receptor, family 7, subfamily C, member 2 O60412 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14983052 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR7D2 HGNC:8378 olfactory receptor, family 7, subfamily D, member 2 Q96RA2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 14983052 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR7D4 HGNC:8380 olfactory receptor, family 7, subfamily D, member 4 Q8NG98 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR7E24 HGNC:8396 olfactory receptor, family 7, subfamily E, member 24 Q6IFN5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR7G1 HGNC:8465 olfactory receptor, family 7, subfamily G, member 1 Q8NGA0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 58 7 plasma membrane plasma membrane Human Eutheria Bilateria OR7G2 HGNC:8466 olfactory receptor, family 7, subfamily G, member 2 Q8NG99 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Human Euarchontoglires Bilateria OR7G3 HGNC:8467 olfactory receptor, family 7, subfamily G, member 3 Q8NG95 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Human Euarchontoglires Eumetazoa OR8A1 HGNC:8469 olfactory receptor, family 8, subfamily A, member 1 Q8NGG7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR8B12 HGNC:15307 olfactory receptor, family 8, subfamily B, member 12 Q8NGG6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Bilateria OR8B2 HGNC:8471 olfactory receptor, family 8, subfamily B, member 2 Q96RD0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR8B3 HGNC:8472 olfactory receptor, family 8, subfamily B, member 3 Q8NGG8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR8B4 HGNC:8473 olfactory receptor, family 8, subfamily B, member 4 Q96RC9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR8B8 HGNC:8477 olfactory receptor, family 8, subfamily B, member 8 Q15620 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11705801 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR8D1 HGNC:8481 olfactory receptor, family 8, subfamily D, member 1 Q8WZ84 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Theria Bilateria OR8D2 HGNC:8482 olfactory receptor, family 8, subfamily D, member 2 Q9GZM6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14983052 plasma membrane 50 7 plasma membrane plasma membrane Homininae Theria Eumetazoa OR8D4 HGNC:14840 olfactory receptor, family 8, subfamily D, member 4 Q8NGM9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa OR8G1 HGNC:8484 olfactory receptor, family 8, subfamily G, member 1 Q15617 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR8G2 HGNC:8485 olfactory receptor, family 8, subfamily G, member 2 Q15614 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR8G5 HGNC:19622 olfactory receptor, family 8, subfamily G, member 5 Q8NG78 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR8H1 HGNC:14824 olfactory receptor, family 8, subfamily H, member 1 Q8NGG4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria NA OR8H2 HGNC:15308 olfactory receptor, family 8, subfamily H, member 2 Q8N162 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae Eumetazoa OR8H3 HGNC:15309 olfactory receptor, family 8, subfamily H, member 3 Q8N146 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR8I2 HGNC:15310 olfactory receptor, family 8, subfamily I, member 2 Q8N0Y5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR8J1 HGNC:14855 olfactory receptor, family 8, subfamily J, member 1 Q8NGP2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae NA OR8J2 HGNC:15311 olfactory receptor, family 8, subfamily J, member 2 (gene/pseudogene) Q8NGG1 Membrane; Multi-pass membrane protein (Potential). plasma membrane 73 7 plasma membrane plasma membrane NA NA NA OR8J3 HGNC:15312 olfactory receptor, family 8, subfamily J, member 3 Q8NGG0 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Bilateria OR8K1 HGNC:14831 olfactory receptor, family 8, subfamily K, member 1 Q8NGG5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria NA OR8K3 HGNC:15313 olfactory receptor, family 8, subfamily K, member 3 Q8NH51 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia NA OR8K5 HGNC:15315 olfactory receptor, family 8, subfamily K, member 5 Q8NH50 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 47 7 plasma membrane plasma membrane Homininae Eutheria Eumetazoa OR8S1 HGNC:19628 olfactory receptor, family 8, subfamily S, member 1 Q8NH09 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Bilateria OR8U1 HGNC:19611 olfactory receptor, family 8, subfamily U, member 1 Q8NH10 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR8U8 HGNC:27538 olfactory receptor, family 8, subfamily U, member 8 P0C7N1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA NA OR8U9 HGNC:29166 olfactory receptor, family 8, subfamily U, member 9 P0C7N5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR9A2 HGNC:15093 olfactory receptor, family 9, subfamily A, member 2 Q8NGT5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane Human Human NA OR9A4 HGNC:15095 olfactory receptor, family 9, subfamily A, member 4 Q8NGU2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 30 7 plasma membrane plasma membrane NA NA NA OR9G1 HGNC:15319 olfactory receptor, family 9, subfamily G, member 1 Q8NH87 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 94 7 plasma membrane plasma membrane Theria Theria NA OR9G4 HGNC:15322 olfactory receptor, family 9, subfamily G, member 4 Q8NGQ1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria NA OR9G9 HGNC:31940 olfactory receptor, family 9, subfamily G, member 9 P0C7N8 Cell membrane; Multi-pass membrane protein. Nucleus (GO:0005634) plasma membrane 100 7 plasma membrane plasma membrane NA NA Eumetazoa OR9I1 HGNC:14718 olfactory receptor, family 9, subfamily I, member 1 Q8NGQ6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Eumetazoa OR9K2 HGNC:15339 olfactory receptor, family 9, subfamily K, member 2 Q8NGE7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa OR9Q1 HGNC:14724 olfactory receptor, family 9, subfamily Q, member 1 Q8NGQ5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 66 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa OR9Q2 HGNC:15328 olfactory receptor, family 9, subfamily Q, member 2 Q8NGE9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Eutheria Eumetazoa ORAI1 HGNC:25896 ORAI calcium release-activated calcium modulator 1 Q96D31 Cell membrane; Multi-pass membrane protein. Note=Isoform beta is more mobile in the plasma membrane. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Cytoplasm (GO:0005737) 16645049,16921385,16921383,16921383 plasma membrane 100 4 cytoplasm. plasma membrane multiple Chordata Bilateria NA ORAI2 HGNC:21667 ORAI calcium release-activated calcium modulator 2 Q96SN7 Membrane; Multi-pass membrane protein (By similarity). plasma membrane 66 4 plasma membrane plasma membrane Bilateria Bilateria Holozoa ORAI3 HGNC:28185 ORAI calcium release-activated calcium modulator 3 Q9BRQ5 Membrane; Multi-pass membrane protein (By similarity). plasma membrane 59 4 plasma membrane plasma membrane Mammalia Mammalia Holozoa ORAOV1 HGNC:17589 oral cancer overexpressed 1 Q8WV07 cytoplasm 49 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota ORC1 HGNC:8487 origin recognition complex, subunit 1 Q13415 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11931757,11779870,10681582,11716535 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms ORC2 HGNC:8488 origin recognition complex, subunit 2 Q13416 Nucleus. Nucleus (GO:0005634) 10954718 nucleus 100 1 nucleus nucleus Eukaryota Eukaryota Eukaryota ORC3 HGNC:8489 origin recognition complex, subunit 3 Q9UBD5 Nucleus. Nucleus (GO:0005634) 11395502 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota ORC4 HGNC:8490 origin recognition complex, subunit 4 O43929 Nucleus. Nucleus (GO:0005634) 10954718 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms ORC5 HGNC:8491 origin recognition complex, subunit 5 O43913 Nucleus. Nucleus (GO:0005634) 11323433,10954718 nucleus 100 1 nucleus nucleus Opisthokonta Eukaryota Eukaryota ORC6 HGNC:17151 origin recognition complex, subunit 6 Q9Y5N6 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11323433,11323433 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota ORM1 HGNC:8498 orosomucoid 1 P02763 Secreted. Extracellular (GO:0005576) 2822385,16188874 secreted 100 0 secreted secreted NA NA Amniota ORM2 HGNC:8499 orosomucoid 2 P19652 Secreted. Extracellular (GO:0005576) 3631077,16188874 secreted 100 0 secreted secreted NA NA Amniota ORMDL1 HGNC:16036 ORM1-like 1 (S. cerevisiae) Q9P0S3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12093374 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Chordata Eukaryota Eukaryota ORMDL2 HGNC:16037 ORM1-like 2 (S. cerevisiae) Q53FV1 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12093374 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Euteleostomi Eukaryota ORMDL3 HGNC:16038 ORM1-like 3 (S. cerevisiae) Q8N138 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12093374 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Eukaryota Eukaryota OS9 HGNC:16994 osteosarcoma amplified 9, endoplasmic reticulum lectin Q13438 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17932042,/15721254,15721254 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Theria Eukaryota Eukaryota OSBP HGNC:8503 oxysterol binding protein P22059 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 10588946,17081983,10588946,17081983 cytoplasm 19 0 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Eukaryota OSBP2 HGNC:8504 oxysterol binding protein 2 Q969R2 Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11278871,11802775 nucleus 17 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota OSBPL10 HGNC:16395 oxysterol binding protein-like 10 Q9BXB5 Cytoplasm (GO:0005737) endoplasmic reticulum membrane 20 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Deuterostomia Eukaryota OSBPL11 HGNC:16397 oxysterol binding protein-like 11 Q9BXB4 Cytoplasm (GO:0005737); Nucleus (GO:0005634) none,17081983,17081983 endoplasmic reticulum membrane 21 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota OSBPL1A HGNC:16398 oxysterol binding protein-like 1A Q9BXW6 Late endosome. Note=Co-localizes with RAB7A, RAB9A and LAMP1 in late endosomes. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11279184,11279184/17081983,17081983 cytoplasm 22 0 cytoplasm. endosome. nucleus multiple Bilateria Eukaryota Cell.Organisms OSBPL2 HGNC:15761 oxysterol binding protein-like 2 Q9H1P3 Golgi apparatus (GO:0005794) 11279184 cytoplasm 24 0 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota OSBPL3 HGNC:16370 oxysterol binding protein-like 3 Q9H4L5 Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Endoplasmic reticulum membrane (GO:0005789) 11568019,14593528,14593528,14593528,14593528 cytoplasm 23 0 cytoplasm. endoplasmic reticulum membrane. golgi apparatus. nucleus multiple Euteleostomi Eukaryota Eukaryota OSBPL5 HGNC:16392 oxysterol binding protein-like 5 Q9H0X9 Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10588946,11735225,17081983 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum membrane. nucleus multiple Opisthokonta Eukaryota Eukaryota OSBPL6 HGNC:16388 oxysterol binding protein-like 6 Q9BZF3 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 14593528,14593528,14593528 cytoplasm 19 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota OSBPL7 HGNC:16387 oxysterol binding protein-like 7 Q9BZF2 Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14593528,14593528,14593528 cytoplasm 20 0 cytoplasm. endoplasmic reticulum multiple Euteleostomi Eukaryota Eukaryota OSBPL8 HGNC:16396 oxysterol binding protein-like 8 Q9BZF1 Mitochondrion (GO:0005739) 15598749 endoplasmic reticulum membrane 48 1 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota OSBPL9 HGNC:16386 oxysterol binding protein-like 9 Q96SU4 Cytoplasm (GO:0005737);Nucleus (GO:0005634) /17081983 endoplasmic reticulum membrane 20 1 nucleus nucleus Human Bilateria Eukaryota OSCAR HGNC:29960 osteoclast associated, immunoglobulin-like receptor Q8IYS5 Isoform 1: Secreted (Potential). Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11805147 secreted 19 0 secreted secreted Amniota Amniota NA OSCP1 HGNC:29971 organic solute carrier partner 1 Q8WVF1 Basal cell membrane. Note=Syncytiotrophoblast in placenta. nucleus 51 0 nucleus nucleus Bilateria Eukaryota Eukaryota OSER1 HGNC:16105 oxidative stress responsive serine-rich 1 Q9NX31 nucleus 62 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria OSGEP HGNC:18028 O-sialoglycoprotein endopeptidase Q9NPF4 mitochondrion 18 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms OSGEPL1 HGNC:23075 O-sialoglycoprotein endopeptidase-like 1 Q9H4B0 mitochondrion 19 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms OSGIN1 HGNC:30093 oxidative stress induced growth inhibitor 1 Q9UJX0 Extracellular (GO:0005576) 11459809 cytoplasm 65 0 secreted secreted Amniota Deuterostomia Opisthokonta OSGIN2 HGNC:1355 oxidative stress induced growth inhibitor family member 2 Q9Y236 Cytoplasm (GO:0005737) 9933573 cytoplasm 54 0 cytoplasm cytoplasm Amniota Deuterostomia Opisthokonta OSM HGNC:8506 oncostatin M P13725 Secreted. Extracellular (GO:0005576) 8999038 secreted 100 0 secreted secreted Eutheria Eutheria Boreoeutheria OSMR HGNC:8507 oncostatin M receptor Q99650 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11786531 plasma membrane 13 1 plasma membrane plasma membrane Amniota Amniota Holozoa OSR1 HGNC:8111 odd-skipped related transciption factor 1 Q8TAX0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 29 0 nucleus nucleus Theria Euteleostomi Eukaryota OSR2 HGNC:15830 odd-skipped related transciption factor 2 Q8N2R0 Nucleus (Potential). Nucleus (GO:0005634) 15670784 nucleus 28 0 nucleus nucleus Eutheria Opisthokonta Eukaryota OST4 HGNC:32483 oligosaccharyltransferase 4 homolog (S. cerevisiae) P0C6T2 Endoplasmic reticulum membrane; Single-pass type III membrane protein. Note=The single transmembrane helix has a kink in the middle of the transmembrane span. mitochondrion membrane 14 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Opisthokonta OSTC HGNC:24448 oligosaccharyltransferase complex subunit (non-catalytic) Q9NRP0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 28 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota OSTF1 HGNC:8510 osteoclast stimulating factor 1 Q92882 Cytoplasm (Probable). Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737) 15135048,17081983,15135048,17081983 nucleus 30 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms OSTM1 HGNC:21652 osteopetrosis associated transmembrane protein 1 Q86WC4 Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Lysosome (GO:0005764); Endosome (GO:0005768) 12826607,12826607,17081983,16525474,16525474 secreted 44 1 cytoplasm. endosome. lysosome. lysosome membrane. plasma membrane multiple Bilateria Bilateria Eumetazoa OSTN HGNC:29961 osteocrin P61366 Secreted. Extracellular (GO:0005576) 14523025,15044443 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Euteleostomi OTC HGNC:8512 ornithine carbamoyltransferase P00480 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 6372096,6169723,6942417,7085676,3943133,6942417,6169723,3943133 mitochondrion 100 0 cytoplasm. mitochondrion multiple Euteleostomi Cell.Organisms Cell.Organisms OTOA HGNC:16378 otoancorin Q7RTW8 Apical cell membrane; Lipid-anchor, GPI- anchor; Extracellular side (Probable). Secreted, extracellular space, extracellular matrix (Probable). Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes (By similarity). Plasma membrane (GO:0005886) 11972037 secreted 57 1 plasma membrane. secreted multiple Tetrapoda Chordata Eumetazoa OTOF HGNC:8515 otoferlin Q9HC10 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type II membrane protein (By similarity). Basolateral cell membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Cell membrane; Single-pass type II membrane protein (By similarity). Note=Detected at basolateral cell membrane with synaptic vesicles surrounding the ribbon and at the presynaptic plasma membrane in the inner hair cells (IHCs). Colocalizes with GPR25 and RAB8B in inner hair cells (By similarity). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) ,10192385 endoplasmic reticulum membrane 20 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota OTOG HGNC:8516 otogelin Q6ZRI0 Apical cell membrane; Peripheral membrane protein; Extracellular side (By similarity). Secreted, extracellular space (By similarity). Note=Found in fiber-like structures during the maturation process of the tectorial membrane (By similarity). Extracellular (GO:0005576) 9405633,14527306 secreted 18 0 secreted secreted Euteleostomi Euteleostomi Holozoa OTOGL HGNC:26901 otogelin-like Q3ZCN5 Secreted (Potential). secreted 16 0 secreted secreted Euteleostomi Euteleostomi Holozoa OTOL1 HGNC:34071 otolin 1 A6NHN0 Secreted (By similarity). secreted 40 0 secreted secreted Amniota Euteleostomi Cell.Organisms OTOP1 HGNC:19656 otopetrin 1 Q7RTM1 Membrane; Multi-pass membrane protein. Secreted, extracellular space. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium (By similarity). Plasma membrane (GO:0005886) 12651873 golgi apparatus membrane 39 12 plasma membrane. secreted multiple Euteleostomi Euteleostomi Bilateria OTOP2 HGNC:19657 otopetrin 2 Q7RTS6 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 50 12 golgi apparatus membrane golgi apparatus membrane Theria Bilateria Eumetazoa OTOP3 HGNC:19658 otopetrin 3 Q7RTS5 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) golgi apparatus membrane 41 12 golgi apparatus membrane golgi apparatus membrane Amniota Amniota Bilateria OTOR HGNC:8517 otoraplin Q9NRC9 Secreted (Potential). Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 11161796,11161796 endoplasmic reticulum membrane 35 0 golgi apparatus. secreted multiple Tetrapoda Euteleostomi Bilateria OTOS HGNC:22644 otospiralin Q8NHW6 Secreted (Probable). Extracellular (GO:0005576) 12687421 secreted 62 0 secreted secreted Euteleostomi Euteleostomi Euteleostomi OTP HGNC:8518 orthopedia homeobox Q5XKR4 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10458915,10458915 nucleus 100 0 cytoplasm. nucleus multiple Theria Deuterostomia Opisthokonta OTUB1 HGNC:23077 OTU deubiquitinase, ubiquitin aldehyde binding 1 Q96FW1 Cytoplasm (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota OTUB2 HGNC:20351 OTU deubiquitinase, ubiquitin aldehyde binding 2 Q96DC9 cytoplasm 36 0 cytoplasm cytoplasm Mammalia Tetrapoda Eukaryota OTUD1 HGNC:27346 OTU deubiquitinase 1 Q5VV17 cytoplasm 11 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota OTUD3 HGNC:29038 OTU deubiquitinase 3 Q5T2D3 cytoplasm 8 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota OTUD4 HGNC:24949 OTU deubiquitinase 4 Q01804 Cytoplasm (GO:0005737) 17081983 cytoplasm 18 0 cytoplasm cytoplasm Tetrapoda Deuterostomia Eukaryota OTUD5 HGNC:25402 OTU deubiquitinase 5 Q96G74 cytoplasm 8 0 cytoplasm cytoplasm Eutheria Eukaryota NA OTUD6A HGNC:32312 OTU deubiquitinase 6A Q7L8S5 cytoplasm 19 0 cytoplasm cytoplasm Eutheria Eutheria Eukaryota OTUD6B HGNC:24281 OTU domain containing 6B Q8N6M0 cytoplasm 17 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota OTUD7A HGNC:20718 OTU deubiquitinase 7A Q8TE49 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) cytoplasm 10 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa OTUD7B HGNC:16683 OTU deubiquitinase 7B Q6GQQ9 Cytoplasm. Nucleus. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. Cytoplasm (GO:0005737) 12682062 nucleus 68 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa OTULIN HGNC:25118 OTU deubiquitinase with linear linkage specificity Q96BN8 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Bilateria OTX1 HGNC:8521 orthodenticle homeobox 1 P32242 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10624946,10624946 nucleus 57 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota OTX2 HGNC:8522 orthodenticle homeobox 2 P32243 Nucleus (Probable). Nucleus (GO:0005634) 10354480 nucleus 73 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota OVCA2 HGNC:24203 ovarian tumor suppressor candidate 2 Q8WZ82 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota OVCH1 HGNC:23080 ovochymase 1 Q7RTY7 Secreted (By similarity). Extracellular (GO:0005576) secreted 29 0 secreted secreted Catarrhini Eutheria Cell.Organisms OVCH2 HGNC:29970 ovochymase 2 (gene/pseudogene) Q7RTZ1 Secreted (By similarity). secreted 29 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms OVGP1 HGNC:8524 oviductal glycoprotein 1, 120kDa Q12889 Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules. Extracellular (GO:0005576) 7819450 secreted 36 0 secreted secreted Mammalia Mammalia Cell.Organisms OVOL1 HGNC:8525 ovo-like zinc finger 1 O14753 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 94 0 nucleus nucleus Bilateria Bilateria Eukaryota OVOL2 HGNC:15804 ovo-like zinc finger 2 Q9BRP0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota OVOL3 HGNC:14186 ovo-like zinc finger 3 O00110 Nucleus (Potential). nucleus 37 0 nucleus nucleus NA NA Eukaryota OXA1L HGNC:8526 oxidase (cytochrome c) assembly 1-like Q15070 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7991568,12191770,12191770 mitochondrion membrane 100 4 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Eukaryota Eukaryota Cell.Organisms OXCT1 HGNC:8527 3-oxoacid CoA transferase 1 P55809 Mitochondrion matrix. Mitochondrion (GO:0005739) 10964512,15598749 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms OXCT2 HGNC:18606 3-oxoacid CoA transferase 2 Q9BYC2 Mitochondrion. Mitochondrion (GO:0005739) 11756565 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms OXER1 HGNC:24884 oxoeicosanoid (OXE) receptor 1 Q8TDS5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 12065583,12606753 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Metazoa OXGR1 HGNC:4531 oxoglutarate (alpha-ketoglutarate) receptor 1 Q96P68 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa OXLD1 HGNC:27901 oxidoreductase-like domain containing 1 Q5BKU9 mitochondrion 46 0 mitochondrion mitochondrion Eutheria Eutheria Opisthokonta OXNAD1 HGNC:25128 oxidoreductase NAD-binding domain containing 1 Q96HP4 mitochondrion 2 0 mitochondrion mitochondrion Deuterostomia Opisthokonta Cell.Organisms OXR1 HGNC:15822 oxidation resistance 1 Q8N573 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15060142,15060142,15060142,17081983 mitochondrion 100 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms OXSM HGNC:26063 3-oxoacyl-ACP synthase, mitochondrial Q9NWU1 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms OXSR1 HGNC:8508 oxidative stress responsive 1 O95747 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Integral to membrane (GO:0016021) 14707132,17081983,14707132,14707132 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms OXT HGNC:8528 oxytocin/neurophysin I prepropeptide P01178 Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12183418,12183418, secreted 100 0 cytoplasm. secreted multiple Theria Deuterostomia Bilateria OXTR HGNC:8529 oxytocin receptor P30559 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9283088 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa P2RX1 HGNC:8533 purinergic receptor P2X, ligand-gated ion channel, 1 P51575 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10816552,16885977 plasma membrane 32 2 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota P2RX2 HGNC:15459 purinergic receptor P2X, ligand-gated ion channel, 2 Q9UBL9 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15313628 plasma membrane 26 2 plasma membrane plasma membrane Theria Euteleostomi Eukaryota P2RX3 HGNC:8534 purinergic receptor P2X, ligand-gated ion channel, 3 P56373 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9221902 plasma membrane 32 2 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota P2RX4 HGNC:8535 purinergic receptor P2X, ligand-gated ion channel, 4 Q99571 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9016352 plasma membrane 36 2 plasma membrane plasma membrane Euteleostomi Deuterostomia Eukaryota P2RX5 HGNC:8536 purinergic receptor P2X, ligand-gated ion channel, 5 Q93086 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9414125 plasma membrane 26 2 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota P2RX6 HGNC:8538 purinergic receptor P2X, ligand-gated ion channel, 6 O15547 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12088286 plasma membrane 24 2 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota P2RX7 HGNC:8537 purinergic receptor P2X, ligand-gated ion channel, 7 Q99572 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11943260 plasma membrane 100 2 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota P2RY1 HGNC:8539 purinergic receptor P2Y, G-protein coupled, 1 P47900 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12393588 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa P2RY10 HGNC:19906 purinergic receptor P2Y, G-protein coupled, 10 O00398 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa P2RY11 HGNC:8540 purinergic receptor P2Y, G-protein coupled, 11 Q96G91 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10947861 plasma membrane 100 7 plasma membrane plasma membrane NA NA Metazoa P2RY12 HGNC:18124 purinergic receptor P2Y, G-protein coupled, 12 Q9H244 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11196645 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Metazoa P2RY13 HGNC:4537 purinergic receptor P2Y, G-protein coupled, 13 Q9BPV8 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11546776 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria P2RY14 HGNC:16442 purinergic receptor P2Y, G-protein coupled, 14 Q15391 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa P2RY2 HGNC:8541 purinergic receptor P2Y, G-protein coupled, 2 P41231 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8248130,9211988 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Tetrapoda Eumetazoa P2RY4 HGNC:8542 pyrimidinergic receptor P2Y, G-protein coupled, 4 P51582 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12603858 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa P2RY6 HGNC:8543 pyrimidinergic receptor P2Y, G-protein coupled, 6 Q15077 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11114308,8670200 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa P2RY8 HGNC:15524 purinergic receptor P2Y, G-protein coupled, 8 Q86VZ1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa P4HA1 HGNC:8546 prolyl 4-hydroxylase, alpha polypeptide I P13674 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 2543975 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms P4HA2 HGNC:8547 prolyl 4-hydroxylase, alpha polypeptide II O15460 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms P4HA3 HGNC:30135 prolyl 4-hydroxylase, alpha polypeptide III Q7Z4N8 Endoplasmic reticulum lumen (Probable). endoplasmic reticulum 25 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Cell.Organisms P4HB HGNC:8548 prolyl 4-hydroxylase, beta polypeptide P07237 Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein (Potential). Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Extracellular (GO:0005576); Nucleolus (GO:0005730); Zymogen granule (GO:0042588); Mitochondrion (GO:0005739) 3611107,1667665,3611107,1559965,11790298,16278343,15598749 endoplasmic reticulum 79 0 endoplasmic reticulum. melanosome. mitochondrion. nucleus. secreted multiple Bilateria Eukaryota Cell.Organisms P4HTM HGNC:28858 prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Q9NXG6 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 12163023 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Mammalia Deuterostomia Cell.Organisms PA2G4 HGNC:8550 proliferation-associated 2G4, 38kDa Q9UQ80 Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytosol (GO:0005829); Cytoplasm (GO:0005737) 7556453,15064750,17081983,15635413,11790298,15064750,15064750,17081983 nucleus 27 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PAAF1 HGNC:25687 proteasomal ATPase-associated factor 1 Q9BRP4 nucleus 9 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms PABPC1 HGNC:8554 poly(A) binding protein, cytoplasmic 1 P11940 Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9582337,15663938,9582337 cytoplasm 94 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PABPC1L HGNC:15797 poly(A) binding protein, cytoplasmic 1-like Q4VXU2 cytoplasm 68 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PABPC1L2A HGNC:27989 poly(A) binding protein, cytoplasmic 1-like 2A Q5JQF8 cytoplasm 75 0 cytoplasm cytoplasm Euarchontoglires Euarchontoglires NA PABPC1L2B HGNC:31852 poly(A) binding protein, cytoplasmic 1-like 2B Q5JQF8 cytoplasm 75 0 cytoplasm cytoplasm Euarchontoglires Euarchontoglires NA PABPC3 HGNC:8556 poly(A) binding protein, cytoplasmic 3 Q9H361 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10358005,10358005 cytoplasm 84 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PABPC4 HGNC:8557 poly(A) binding protein, cytoplasmic 4 (inducible form) Q13310 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737) 8524242 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PABPC4L HGNC:31955 poly(A) binding protein, cytoplasmic 4-like P0CB38 cytoplasm 70 0 cytoplasm cytoplasm NA NA Cell.Organisms PABPC5 HGNC:13629 poly(A) binding protein, cytoplasmic 5 Q96DU9 Cytoplasm (By similarity). Isoform 2: Mitochondrion matrix. Note=Co- fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase. Cytoplasm (GO:0005737) 11374897 cytoplasm 57 0 cytoplasm. mitochondrion multiple Euarchontoglires Eutheria Cell.Organisms PABPN1 HGNC:8565 poly(A) binding protein, nuclear 1 Q86U42 Nucleus (By similarity). Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). Nucleus (GO:0005634); Nucleoplasm (GO:0005654) 11001936,10358005,10205180 cytoplasm 48 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PABPN1L HGNC:37237 poly(A) binding protein, nuclear 1-like (cytoplasmic) A6NDY0 Cytoplasm (By similarity). cytoplasm 42 0 cytoplasm cytoplasm Mammalia Tetrapoda Cell.Organisms PACRG HGNC:19152 PARK2 co-regulated Q96M98 cytoplasm 46 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PACRGL HGNC:28442 PARK2 co-regulated-like Q8N7B6 nucleus 55 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota PACS1 HGNC:30032 phosphofurin acidic cluster sorting protein 1 Q6VY07 Golgi apparatus, trans-Golgi network (By similarity). Note=Localizes in the perinuclear region, probably the TGN (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 9695949,11331585,11331585,9695949 golgi apparatus 98 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Eukaryota PACS2 HGNC:23794 phosphofurin acidic cluster sorting protein 2 Q86VP3 Endoplasmic reticulum lumen. Mitochondrion. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 15692567,15692567 golgi apparatus 51 0 endoplasmic reticulum. mitochondrion multiple Bilateria Bilateria NA PACSIN1 HGNC:8570 protein kinase C and casein kinase substrate in neurons 1 Q9BY11 Cytoplasm (By similarity). Cell projection (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell projection, ruffle membrane (By similarity). Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. Cytoplasm (GO:0005737) 11179684,11082044 peroxisome membrane 30 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PACSIN2 HGNC:8571 protein kinase C and casein kinase substrate in neurons 2 Q9UNF0 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection (By similarity). Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983/11179684 nucleus 32 0 cytoplasm. endosome multiple Bilateria Bilateria Eukaryota PACSIN3 HGNC:8572 protein kinase C and casein kinase substrate in neurons 3 Q9UKS6 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the inner aspect of the plasma membrane in myotubes (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11179684,17081983 cytoplasm 36 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota PADI1 HGNC:18367 peptidyl arginine deiminase, type I Q9ULC6 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PADI2 HGNC:18341 peptidyl arginine deiminase, type II Q9Y2J8 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PADI3 HGNC:18337 peptidyl arginine deiminase, type III Q9ULW8 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PADI4 HGNC:18368 peptidyl arginine deiminase, type IV Q9UM07 Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12393868,12393868 cytoplasm 48 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms PAEP HGNC:8573 progestagen-associated endometrial protein P09466 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 2113930,3135704,7047733,3768286,2975952,8025274,11278680 secreted 100 0 cytoplasm. secreted multiple Catarrhini Eutheria Euteleostomi PAF1 HGNC:25459 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) Q8N7H5 Nucleus. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin. Nucleus (GO:0005634) 16491129 nucleus 100 0 nucleus nucleus Theria Eukaryota Eukaryota PAFAH1B1 HGNC:8574 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) P43034 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle (By similarity). Nucleus membrane (Potential). Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Cytoplasm (GO:0005737) 7573359 cytoplasm 46 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PAFAH1B2 HGNC:8575 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) P68402 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9144386,17081983,14718574,9144386 cytoplasm 100 0 cytoplasm. secreted multiple Deuterostomia Bilateria Cell.Organisms PAFAH1B3 HGNC:8576 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) Q15102 Cytoplasm. Cytoplasm (GO:0005737) 7669037 cytoplasm 100 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms PAFAH2 HGNC:8579 platelet-activating factor acetylhydrolase 2, 40kDa Q99487 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12406338,8955149,12406338 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms PAG1 HGNC:30043 phosphoprotein associated with glycosphingolipid microdomains 1 Q9NWQ8 Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10790433,10790433,10790433 plasma membrane 100 1 cytoplasm. plasma membrane. secreted multiple Euteleostomi Euteleostomi Euteleostomi PAGE1 HGNC:4107 P antigen family, member 1 (prostate associated) O75459 Cytoplasm (GO:0005737) nucleus 16 0 nucleus nucleus Homininae Homininae NA PAGE2 HGNC:31804 P antigen family, member 2 (prostate associated) Q7Z2X7 nucleus 46 0 nucleus nucleus NA NA Euarchontoglires PAGE2B HGNC:31805 P antigen family, member 2B Q5JRK9 nucleus 47 0 nucleus nucleus NA NA Boreoeutheria PAGE3 HGNC:4110 P antigen family, member 3 (prostate associated) Q5JUK9 nucleus 54 0 nucleus nucleus Homininae Homininae Eutheria PAGE4 HGNC:4108 P antigen family, member 4 (prostate associated) O60829 Cytoplasm (GO:0005737) 12489849 nucleus 36 0 cytoplasm cytoplasm Catarrhini Eutheria NA PAGE5 HGNC:29992 P antigen family, member 5 (prostate associated) Q96GU1 nucleus 34 0 nucleus nucleus Catarrhini Catarrhini Eutheria PAGR1 HGNC:28707 PAXIP1 associated glutamate-rich protein 1 Q9BTK6 Nucleus (GO:0005634) 17500065,17081983 nucleus 79 0 nucleus nucleus Mammalia Deuterostomia Bilateria PAH HGNC:8582 phenylalanine hydroxylase P00439 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PAICS HGNC:8587 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase P22234 Nucleus (GO:0005634) 9108165 cytoplasm 21 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms PAIP1 HGNC:16945 poly(A) binding protein interacting protein 1 Q9H074 Cytoplasm (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9548260,15561729 cytoplasm 9 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota PAIP2 HGNC:17970 poly(A) binding protein interacting protein 2 Q9BPZ3 Cytoplasm. Cytoplasm (GO:0005737) 11172725 cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Craniata PAIP2B HGNC:29200 poly(A) binding protein interacting protein 2B Q9ULR5 cytoplasm 49 0 cytoplasm cytoplasm Theria Bilateria Eumetazoa PAK1 HGNC:8590 p21 protein (Cdc42/Rac)-activated kinase 1 Q13153 Cytoplasm. Cell junction, focal adhesion. Cell membrane. Note=Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cell projection (GO:0042995) 17081983/12006652,12089369,12198493 cytoplasm 37 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms PAK1IP1 HGNC:20882 PAK1 interacting protein 1 Q9NWT1 Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11371639,15635413 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PAK2 HGNC:8591 p21 protein (Cdc42/Rac)-activated kinase 2 Q13177 Serine/threonine-protein kinase PAK 2: Cytoplasm. PAK-2p34: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane. Endoplasmic reticulum (GO:0005783); Cytosol (GO:0005829); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12560339,12560339,12560339,17081983,17081983 cytoplasm 38 0 cytoplasm. endoplasmic reticulum. nucleus multiple Opisthokonta Eukaryota Cell.Organisms PAK3 HGNC:8592 p21 protein (Cdc42/Rac)-activated kinase 3 O75914 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11259591 cytoplasm 38 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms PAK4 HGNC:16059 p21 protein (Cdc42/Rac)-activated kinase 4 O96013 Cytoplasm. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. Golgi membrane (GO:0000139); Cytosol (GO:0005829);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9822598,12356872,12356872/17081983,17081983 cytoplasm 100 1 cytoplasm. golgi apparatus membrane. nucleus multiple Bilateria Bilateria Cell.Organisms PAK6 HGNC:16061 p21 protein (Cdc42/Rac)-activated kinase 6 Q9NQU5 Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11278661,11773441,11773441,11278661 cytoplasm 45 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms PAK7 HGNC:15916 p21 protein (Cdc42/Rac)-activated kinase 7 Q9P286 Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival. Mitochondrion (GO:0005739) 12897128 cytoplasm 50 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms PALB2 HGNC:26144 partner and localizer of BRCA2 Q86YC2 Nucleus. Note=Colocalizes with BRCA2 in nuclear foci. Nucleus (GO:0005634) 16793542 nucleus 100 0 nucleus nucleus Amniota Amniota Deuterostomia PALD1 HGNC:23530 phosphatase domain containing, paladin 1 Q9ULE6 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PALLD HGNC:17068 palladin, cytoskeletal associated protein Q8WX93 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to stress fibers and Z lines. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Actin filament (GO:0005884) 11598191,11598191,15147863 plasma membrane 16 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa PALM HGNC:8594 paralemmin O75781 Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Basolateral cell membrane; Lipid-anchor (By similarity). Apicolateral cell membrane; Lipid-anchor (By similarity). Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 9813098/17081983 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata PALM2 HGNC:15845 paralemmin 2 Q8IXS6 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Plasma membrane (GO:0005886) 11478809 nucleus 8 0 nucleus nucleus NA NA Craniata PALM3 HGNC:33274 paralemmin 3 A6NDB9 Cytoplasm (By similarity). Cell membrane; Lipid-anchor (By similarity). nucleus 27 0 nucleus nucleus Theria Theria Mammalia PALMD HGNC:15846 palmdelphin Q9NP74 Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11707320,17081983,17081983 cytoplasm 46 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata PAM HGNC:8596 peptidylglycine alpha-amidating monooxygenase P19021 Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Note=Secreted from secretory granules. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Extracellular (GO:0005576); Axon (GO:0030424); Dendrite (GO:0030425) 9562574,17081983,7680192,7680192,1491686,14559897,17081983,1491686,14559897,14559897 cytoplasm 23 1 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus. secreted multiple Bilateria Cell.Organisms Cell.Organisms PAM16 HGNC:29679 presequence translocase-associated motor 16 homolog (S. cerevisiae) Q9Y3D7 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. mitochondrion 59 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota PAMR1 HGNC:24554 peptidase domain containing associated with muscle regeneration 1 Q6UXH9 Secreted (Potential). secreted 88 0 secreted secreted Chordata Chordata Cell.Organisms PAN2 HGNC:20074 PAN2 poly(A) specific ribonuclease subunit Q504Q3 Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Cytoplasm (GO:0005737) 14583602 cytoplasm 21 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota PAN3 HGNC:29991 PAN3 poly(A) specific ribonuclease subunit Q58A45 Cytoplasm. Cytoplasm (GO:0005737) 14583602 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota PANK1 HGNC:8598 pantothenate kinase 1 Q8TE04 Cytoplasm. Cytoplasm (GO:0005737) 14523052 cytoplasm 100 1 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms PANK2 HGNC:15894 pantothenate kinase 2 Q9BZ23 Isoform 1: Mitochondrion. Isoform 2: Cytoplasm (Potential). Isoform 3: Cytoplasm (Potential). Isoform 4: Cytoplasm (Potential). Cytoplasm (GO:0005737) 7084227 cytoplasm 78 2 cytoplasm. mitochondrion multiple Deuterostomia Eukaryota Cell.Organisms PANK3 HGNC:19365 pantothenate kinase 3 Q9H999 Cytoplasm (Probable). cytoplasm 76 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms PANK4 HGNC:19366 pantothenate kinase 4 Q9NVE7 Cytoplasm (Probable). cytoplasm 91 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms PANX1 HGNC:8599 pannexin 1 Q96RD7 Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 50 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Chordata PANX2 HGNC:8600 pannexin 2 Q96RD6 Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction. plasma membrane 73 4 plasma membrane plasma membrane Amniota Euteleostomi Bilateria PANX3 HGNC:20573 pannexin 3 Q96QZ0 Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction. Plasma membrane (GO:0005886) endoplasmic reticulum membrane 43 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Chordata PAOX HGNC:20837 polyamine oxidase (exo-N4-amino) Q6QHF9 Peroxisome (By similarity). Cytoplasm (By similarity). Peroxisome (GO:0005777) 12660232 nucleus 12 0 peroxisome peroxisome Bilateria Eukaryota Cell.Organisms PAPD4 HGNC:26776 PAP associated domain containing 4 Q6PIY7 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 58 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota PAPD5 HGNC:30758 PAP associated domain containing 5 Q8NDF8 Nucleus. Cytoplasm. Note=Predominantly expressed in the cytoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10066793,15635413 cytoplasm 22 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PAPD7 HGNC:16705 PAP associated domain containing 7 Q5XG87 Nucleus (Probable). Nucleus (GO:0005634) nucleus 26 2 nucleus nucleus Chordata Eukaryota Eukaryota PAPLN HGNC:19262 papilin, proteoglycan-like sulfated glycoprotein O95428 Secreted (Potential). Extracellular (GO:0005576) secreted 36 0 secreted secreted Tetrapoda Bilateria Eukaryota PAPOLA HGNC:14981 poly(A) polymerase alpha P51003 Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic. nucleus 98 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PAPOLB HGNC:15970 poly(A) polymerase beta (testis specific) Q9NRJ5 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11150526,11150526 nucleus 85 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PAPOLG HGNC:14982 poly(A) polymerase gamma Q9BWT3 Nucleus. Nucleus (GO:0005634) 11431479 nucleus 100 1 nucleus nucleus Eukaryota Eukaryota Cell.Organisms PAPPA HGNC:8602 pregnancy-associated plasma protein A, pappalysin 1 Q13219 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10077652,12744930,12414897,6084247,12414897 secreted 100 0 cytoplasm. secreted multiple Euteleostomi Deuterostomia Cell.Organisms PAPPA2 HGNC:14615 pappalysin 2 Q9BXP8 Secreted (By similarity). Nucleus (GO:0005634); Extracellular (GO:0005576) 11597188,11264294 secreted 35 0 nucleus. secreted multiple Euteleostomi Deuterostomia Cell.Organisms PAPSS1 HGNC:8603 3'-phosphoadenosine 5'-phosphosulfate synthase 1 O43252 Nucleus (GO:0005634) 10657990 mitochondrion 50 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PAPSS2 HGNC:8604 3'-phosphoadenosine 5'-phosphosulfate synthase 2 O95340 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10657990,10657990 mitochondrion 54 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PAQR3 HGNC:30130 progestin and adipoQ receptor family member III Q6TCH7 Golgi apparatus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 100 7 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Eukaryota PAQR4 HGNC:26386 progestin and adipoQ receptor family member IV Q8N4S7 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 16044242 golgi apparatus membrane 15 7 plasma membrane plasma membrane Mammalia Bilateria Eukaryota PAQR5 HGNC:29645 progestin and adipoQ receptor family member V Q9NXK6 Membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 15 8 golgi apparatus membrane golgi apparatus membrane Deuterostomia Deuterostomia Eukaryota PAQR6 HGNC:30132 progestin and adipoQ receptor family member VI Q6TCH4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 18 8 plasma membrane plasma membrane Human Euteleostomi Eukaryota PAQR7 HGNC:23146 progestin and adipoQ receptor family member VII Q86WK9 Cell membrane; Multi-pass membrane protein (By similarity). Peroxisome (GO:0005777); Plasma membrane (GO:0005886) 12601167, plasma membrane 44 8 peroxisome peroxisome Theria Amniota Eukaryota PAQR8 HGNC:15708 progestin and adipoQ receptor family member VIII Q8TEZ7 Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D. Lysosome (GO:0005764) 11676489 plasma membrane 100 8 lysosome. plasma membrane multiple Deuterostomia Bilateria Eukaryota PAQR9 HGNC:30131 progestin and adipoQ receptor family member IX Q6ZVX9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 14 8 plasma membrane plasma membrane Mammalia Euteleostomi Eukaryota PARD3 HGNC:16051 par-3 family cell polarity regulator Q8TEW0 Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Cytoplasm (GO:0005737); Actin cytoskeleton (GO:0015629); Plasma membrane (GO:0005886) 12234671,17081983,17235357,17203073 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa PARD3B HGNC:14446 par-3 family cell polarity regulator beta Q8TEW8 Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell- cell contact region. Colocalizes with TJP1 to epithelial tight junctions. Plasma membrane (GO:0005886) 12459187 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa PARD6A HGNC:15943 par-6 family cell polarity regulator alpha Q9NPB6 Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Note=Colocalizes with GTP- bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Apical membrane (GO:0016327); Cell junction (GO:0030054) 10954424,12629547,17254974,10954424,17057644 cytoplasm 26 0 cytoplasm. golgi apparatus. nucleus multiple Amniota Bilateria Holozoa PARD6B HGNC:16245 par-6 family cell polarity regulator beta Q9BYG5 Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity). Plasma membrane (GO:0005886) 11260256 cytoplasm 21 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa PARD6G HGNC:16076 par-6 family cell polarity regulator gamma Q9BYG4 Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity). Cytoplasm (GO:0005737) 11260256 cytoplasm 20 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa PARG HGNC:8605 poly (ADP-ribose) glycohydrolase Q86W56 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Mitochondrion. Isoform 5: Mitochondrion matrix. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813) 12878198,8428996,12878198,12878198 nucleus 74 0 cytoplasm. mitochondrion. nucleus multiple NA NA NA PARK2 HGNC:8607 parkin RBR E3 ubiquitin protein ligase O60260 Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Mitochondrion. Note=Mainly localizes in the cytosol. Co-localizes with SYT11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. Relocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 11241385,10791092,15987638,11679592,10791092,11241385 cytoplasm 11 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota PARK7 HGNC:16369 parkinson protein 7 Q99497 Cytoplasm. Nucleus. Mitochondrion. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage. Detected in tau inclusions in brains from neurodegenerative disease patients. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Extracellular (GO:0005576) 9070310,12446870,12526767,15983381,12526767,12446870,9070310,15983381,12526767,15598749,14718574 mitochondrion 29 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Cell.Organisms Cell.Organisms PARL HGNC:18253 presenilin associated, rhomboid-like Q9H300 Mitochondrion inner membrane; Multi-pass membrane protein. P-beta: Nucleus. Note=Translocated into the nucleus by an unknown mechanism. Mitochondrion (GO:0005739) 12774122 mitochondrion membrane 15 8 mitochondrion. mitochondrion membrane. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms PARM1 HGNC:24536 prostate androgen-regulated mucin-like protein 1 Q6UWI2 Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. nucleus 25 1 endosome membrane. golgi apparatus membrane. plasma membrane multiple Theria Theria Euteleostomi PARN HGNC:8609 poly(A)-specific ribonuclease O95453 Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 11230136,9736620,9736620,17081983,15635413,11790298 nucleus 18 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota PARP1 HGNC:270 poly (ADP-ribose) polymerase 1 P09874 Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 1505517,2891139,10944198,15044383,10744766,12897160,17283121,11448953,19059367,15635413,11448953 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms PARP10 HGNC:25895 poly (ADP-ribose) polymerase family, member 10 Q53GL7 Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase. cytoplasm 63 0 cytoplasm. nucleus multiple Chordata Chordata NA PARP11 HGNC:1186 poly (ADP-ribose) polymerase family, member 11 Q9NR21 nucleus 15 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota PARP12 HGNC:21919 poly (ADP-ribose) polymerase family, member 12 Q9H0J9 Nucleus (Probable). secreted 46 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PARP14 HGNC:29232 poly (ADP-ribose) polymerase family, member 14 Q460N5 Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm (By similarity). nucleus 13 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms PARP15 HGNC:26876 poly (ADP-ribose) polymerase family, member 15 Q460N3 Nucleus (Probable). nucleus 18 0 nucleus nucleus Catarrhini Chordata Cell.Organisms PARP16 HGNC:26040 poly (ADP-ribose) polymerase family, member 16 Q8N5Y8 Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. endoplasmic reticulum membrane 27 1 endoplasmic reticulum membrane. nucleus membrane multiple Deuterostomia Eukaryota Eukaryota PARP2 HGNC:272 poly (ADP-ribose) polymerase 2 Q9UGN5 Nucleus. Nucleus (GO:0005634) 10364231,12217960 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms PARP3 HGNC:273 poly (ADP-ribose) polymerase family, member 3 Q9Y6F1 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected. Centrosome (GO:0005813) 12640039 nucleus 22 0 cytoplasm. nucleus multiple Theria Deuterostomia Cell.Organisms PARP4 HGNC:271 poly (ADP-ribose) polymerase family, member 4 Q9UKK3 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Also found in the nucleus, associated with mitotic spindles. Nucleus (GO:0005634) 10477748,10644454 nucleus 14 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms PARP6 HGNC:26921 poly (ADP-ribose) polymerase family, member 6 Q2NL67 Nucleus (GO:0005634) 15273990 nucleus 47 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota PARP8 HGNC:26124 poly (ADP-ribose) polymerase family, member 8 Q8N3A8 nucleus 61 1 nucleus nucleus Euteleostomi Deuterostomia Eukaryota PARP9 HGNC:24118 poly (ADP-ribose) polymerase family, member 9 Q8IXQ6 Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner. Nucleus (GO:0005634) 11110709 nucleus 16 0 cytoplasm. nucleus multiple Chordata Cell.Organisms Cell.Organisms PARPBP HGNC:26074 PARP1 binding protein Q9NWS1 Cytoplasm (By similarity). Nucleus. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA. nucleus 57 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms PARS2 HGNC:30563 prolyl-tRNA synthetase 2, mitochondrial (putative) Q7L3T8 Mitochondrion matrix (Potential). mitochondrion 27 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms PARVA HGNC:14652 parvin, alpha Q9NVD7 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Constituent of focal adhesions. Associates with the actin cytoskeleton. Plasma membrane (GO:0005886); Nucleus (GO:0005634);Nucleus (GO:0005634) 11331308,11171322/17081983 cytoplasm 37 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Opisthokonta PARVB HGNC:14653 parvin, beta Q9HBI1 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia. cytoplasm 36 1 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta PARVG HGNC:14654 parvin, gamma Q9HBI0 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Constituent of focal adhesions (By similarity). Plasma membrane (GO:0005886) 11722847 cytoplasm 20 0 cytoplasm cytoplasm Theria Euteleostomi Opisthokonta PASD1 HGNC:20686 PAS domain containing 1 Q8IV76 Nucleus (Probable). nucleus 26 0 nucleus nucleus Catarrhini Eutheria Bilateria PASK HGNC:17270 PAS domain containing serine/threonine kinase Q96RG2 Cytoplasm. Nucleus. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. Cytoplasm (GO:0005737) 11459942 cytoplasm 22 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms PATE1 HGNC:24664 prostate and testis expressed 1 Q8WXA2 Secreted (Potential). Plasma membrane (GO:0005886) 11880645 secreted 95 0 secreted secreted Catarrhini Catarrhini Eutheria PATE2 HGNC:32249 prostate and testis expressed 2 Q6UY27 Secreted (Potential). secreted 98 0 secreted secreted Homininae Euarchontoglires Eutheria PATE3 HGNC:35426 prostate and testis expressed 3 B3GLJ2 Secreted (Potential). secreted 99 0 secreted secreted NA NA Eutheria PATE4 HGNC:35427 prostate and testis expressed 4 P0C8F1 Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome. secreted 27 0 secreted secreted NA NA Euarchontoglires PATL1 HGNC:26721 protein associated with topoisomerase II homolog 1 (yeast) Q86TB9 Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 10 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota PATL2 HGNC:33630 protein associated with topoisomerase II homolog 2 (yeast) C9JE40 Cytoplasm. Nucleus (By similarity). cytoplasm 11 0 cytoplasm cytoplasm NA NA Opisthokonta PATZ1 HGNC:13071 POZ (BTB) and AT hook containing zinc finger 1 Q9HBE1 Nucleus. Nucleus (GO:0005634) 11719514,11751862 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota PAWR HGNC:8614 PRKC, apoptosis, WT1, regulator Q96IZ0 Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 8943350,8943350,,19632185,,,19632185, cytoplasm 20 0 cytoplasm. endoplasmic reticulum. nucleus multiple Chordata Chordata Bilateria PAX1 HGNC:8615 paired box 1 P15863 Nucleus. Nucleus (GO:0005634) 12504088 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Metazoa PAX2 HGNC:8616 paired box 2 Q02962 Nucleus. Nucleus (GO:0005634) 10908331 nucleus 100 0 nucleus nucleus Human Bilateria Metazoa PAX3 HGNC:8617 paired box 3 P23760 Nucleus. Nucleus (GO:0005634) 7862145,15143176 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota PAX4 HGNC:8618 paired box 4 O43316 Nucleus. Nucleus (GO:0005634) 10967107 nucleus 100 0 nucleus nucleus Mammalia Mammalia Opisthokonta PAX5 HGNC:8619 paired box 5 Q02548 Nucleus. Nucleus (GO:0005634) 12054881 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa PAX6 HGNC:8620 paired box 6 P26367 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12324464,16023139,12324464 nucleus 100 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota PAX7 HGNC:8621 paired box 7 P23759 Nucleus. Nucleus (GO:0005634) 11601392 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota PAX8 HGNC:8622 paired box 8 Q06710 Nucleus. Nucleus (GO:0005634) 9388203,12441357 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa PAX9 HGNC:8623 paired box 9 P55771 Nucleus. Nucleus (GO:0005634) 11374781 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa PAXBP1 HGNC:13579 PAX3 and PAX7 binding protein 1 Q9Y5B6 Nucleus (By similarity). Nucleus (GO:0005634) 17081983 nucleus 94 0 nucleus nucleus Bilateria Eukaryota NA PAXIP1 HGNC:8624 PAX interacting (with transcription-activation domain) protein 1 Q6ZW49 Nucleus matrix (By similarity). Note=Localizes to DNA damage foci upon ionizing radiation. Nucleus (GO:0005634) 10908331,15456759 nucleus 88 0 nucleus nucleus Bilateria Eukaryota Eukaryota PBDC1 HGNC:28790 polysaccharide biosynthesis domain containing 1 Q9BVG4 cytoplasm 31 0 cytoplasm cytoplasm Opisthokonta Opisthokonta NA PBK HGNC:18282 PDZ binding kinase Q96KB5 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15541388,15541388 nucleus 12 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms PBLD HGNC:23301 phenazine biosynthesis-like protein domain containing P30039 cytoplasm 34 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms PBOV1 HGNC:21079 prostate and breast cancer overexpressed 1 Q9GZY1 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11156405,11156405 secreted 8 1 cytoplasm. nucleus multiple NA NA Boreoeutheria PBRM1 HGNC:30064 polybromo 1 Q86U86 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11078522,11078522 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Eukaryota PBX1 HGNC:8632 pre-B-cell leukemia homeobox 1 P40424 Nucleus (By similarity). Nucleus (GO:0005634) 11912494 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota PBX2 HGNC:8633 pre-B-cell leukemia homeobox 2 P40425 Nucleus (Probable). Nucleus (GO:0005634) 10082572 nucleus 79 0 nucleus nucleus Bilateria Bilateria NA PBX3 HGNC:8634 pre-B-cell leukemia homeobox 3 P40426 Nucleus (Probable). Nucleus (GO:0005634) nucleus 80 0 nucleus nucleus Bilateria Bilateria Eukaryota PBX4 HGNC:13403 pre-B-cell leukemia homeobox 4 Q9BYU1 Nucleus (Potential). Nucleus (GO:0005634) 11335119 nucleus 71 0 nucleus nucleus Theria Theria Eukaryota PBXIP1 HGNC:21199 pre-B-cell leukemia homeobox interacting protein 1 Q96AQ6 Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10825160,12360403,10825160,12360403 cytoplasm 14 1 cytoplasm. nucleus multiple Mammalia Mammalia Euteleostomi PC HGNC:8636 pyruvate carboxylase P11498 Mitochondrion matrix. Mitochondrion (GO:0005739) 12437512,10229653,7918683,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PCBD1 HGNC:8646 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha P61457 Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10098606,10098606 cytoplasm 40 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PCBD2 HGNC:24474 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 Q9H0N5 cytoplasm 29 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PCBP1 HGNC:8647 poly(rC) binding protein 1 Q15365 Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12970749,17081983,12970749,17081983,15635413,11790298,15598749 cytoplasm 68 0 cytoplasm. mitochondrion. nucleus multiple Eutheria Eutheria Eukaryota PCBP2 HGNC:8648 poly(rC) binding protein 2 Q15366 Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10772858,12970749,10772858,12970749,17183366 cytoplasm 75 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Eukaryota PCBP3 HGNC:8651 poly(rC) binding protein 3 P57721 Cytoplasm. Cytoplasm (GO:0005737) 14612387 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Eukaryota PCBP4 HGNC:8652 poly(rC) binding protein 4 P57723 Cytoplasm. Cytoplasm (GO:0005737) 14612387 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota PCCA HGNC:8653 propionyl CoA carboxylase, alpha polypeptide P05165 Mitochondrion matrix. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 11136555,14718574 mitochondrion 100 0 mitochondrion. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms PCCB HGNC:8654 propionyl CoA carboxylase, beta polypeptide P05166 Mitochondrion matrix. Mitochondrion (GO:0005739) 6245185 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms PCDH1 HGNC:8655 protocadherin 1 Q08174 Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. Plasma membrane (GO:0005886) 10835267,8508762 plasma membrane 41 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms PCDH10 HGNC:13404 protocadherin 10 Q9P2E7 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 10817752 plasma membrane 32 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PCDH11X HGNC:8656 protocadherin 11 X-linked Q9BZA7 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 14727141,10644456 plasma membrane 25 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms PCDH11Y HGNC:15813 protocadherin 11 Y-linked Q9BZA8 Cell membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 28 3 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms PCDH12 HGNC:8657 protocadherin 12 Q9NPG4 Cell membrane; Single-pass type I membrane protein. Cell junction. Plasma membrane (GO:0005886) 9651350 plasma membrane 20 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PCDH15 HGNC:14674 protocadherin-related 15 Q96QU1 Cell membrane; Single-pass type I membrane protein (By similarity). Isoform 3: Secreted. Plasma membrane (GO:0005886) 11487575 cytoplasm 33 1 plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms PCDH17 HGNC:14267 protocadherin 17 O14917 Cell membrane; Single-pass type I membrane protein (By similarity). Synapse (GO:0045202) 11082270 plasma membrane 26 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PCDH18 HGNC:14268 protocadherin 18 Q9HCL0 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 22 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PCDH19 HGNC:14270 protocadherin 19 Q8TAB3 Cell membrane; Single-pass type I membrane protein (By similarity). plasma membrane 22 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PCDH20 HGNC:14257 protocadherin 20 Q8N6Y1 Cell membrane; Single-pass type I membrane protein (By similarity). Synapse (GO:0045202) 11082270 plasma membrane 19 0 n/a n/a Euteleostomi Deuterostomia Cell.Organisms PCDH7 HGNC:8659 protocadherin 7 O60245 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886);Nucleus (GO:0005634) 9615233/17081983 plasma membrane 100 1 nucleus. plasma membrane multiple Euteleostomi Deuterostomia Cell.Organisms PCDH8 HGNC:8660 protocadherin 8 O95206 Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies (By similarity). Localized to excitatory, but not with inhibitory, synapses (By similarity). Plasma membrane (GO:0005886) 9787079 plasma membrane 22 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PCDH9 HGNC:8661 protocadherin 9 Q9HC56 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 28 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms PCED1A HGNC:16212 PC-esterase domain containing 1A Q9H1Q7 nucleus 33 0 nucleus nucleus Eutheria Deuterostomia Eumetazoa PCED1B HGNC:28255 PC-esterase domain containing 1B Q96HM7 nucleus 24 0 nucleus nucleus Eutheria Bilateria Eumetazoa PCF11 HGNC:30097 PCF11 cleavage and polyadenylation factor subunit O94913 Nucleus. Nucleus (GO:0005634) none,17081983 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota PCGF1 HGNC:17615 polycomb group ring finger 1 Q9BSM1 Nucleus. nucleus 100 0 nucleus nucleus Theria Deuterostomia Eukaryota PCGF2 HGNC:12929 polycomb group ring finger 2 P35227 Nucleus. Nucleus (GO:0005634) 2246278,16182291 nucleus 100 1 nucleus nucleus Theria Tetrapoda Eukaryota PCGF3 HGNC:10066 polycomb group ring finger 3 Q3KNV8 Nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Eukaryota PCGF5 HGNC:28264 polycomb group ring finger 5 Q86SE9 Nucleus. nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota PCGF6 HGNC:21156 polycomb group ring finger 6 Q9BYE7 Nucleus. Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737) 12167161,12167161 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PCID2 HGNC:25653 PCI domain containing 2 Q5JVF3 nucleus 12 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PCIF1 HGNC:16200 PDX1 C-terminal inhibiting factor 1 Q9H4Z3 Nucleus. Nucleus (GO:0005634) 12565871,17126328 nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota PCK1 HGNC:8724 phosphoenolpyruvate carboxykinase 1 (soluble) P35558 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 8490617,8432541,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Bilateria Cell.Organisms Cell.Organisms PCK2 HGNC:8725 phosphoenolpyruvate carboxykinase 2 (mitochondrial) Q16822 Mitochondrion. Mitochondrion (GO:0005739); Cytosol (GO:0005829) 8645161,15315819,8645161 mitochondrion 100 0 cytoplasm. mitochondrion multiple Bilateria Cell.Organisms Cell.Organisms PCLO HGNC:13406 piccolo presynaptic cytomatrix protein Q9Y6V0 Cell junction, synapse (By similarity). Note=Concentrated at the presynaptic side of synaptic junctions (By similarity). secreted 80 0 secreted secreted Euteleostomi Euteleostomi Eukaryota PCM1 HGNC:8727 pericentriolar material 1 Q15154 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Note=Localizes to cytoplasmic granules which are enriched around the centrosome. This centrosomal enrichment requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8120099,15561729,10980597,12403812,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Holozoa PCMT1 HGNC:8728 protein-L-isoaspartate (D-aspartate) O-methyltransferase P22061 Cytoplasm. Cytoplasm (GO:0005737) 3355545 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PCMTD1 HGNC:30483 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 Q96MG8 Cytoplasm (By similarity). cytoplasm 13 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms PCMTD2 HGNC:15882 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Q9NV79 Cytoplasm (By similarity). cytoplasm 11 0 cytoplasm cytoplasm Human Bilateria Cell.Organisms PCNA HGNC:8729 proliferating cell nuclear antigen P12004 Nucleus. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 8673466,11929879,15077116,10930425,15077116,15635413 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PCNP HGNC:30023 PEST proteolytic signal containing nuclear protein Q8WW12 Nucleus. Nucleus (GO:0005634) 12176013 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Holozoa PCNT HGNC:16068 pericentrin O95613 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome. Centrosome (GO:0005813) 12221128,11171385,15561729 cytoplasm 100 0 cytoplasm cytoplasm Amniota Deuterostomia Eumetazoa PCNX HGNC:19740 pecanex homolog (Drosophila) Q96RV3 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 11 16 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Eukaryota PCNXL2 HGNC:8736 pecanex-like 2 (Drosophila) A6NKB5 Membrane; Multi-pass membrane protein (Potential). plasma membrane 59 17 plasma membrane plasma membrane Bilateria Bilateria Eukaryota PCNXL3 HGNC:18760 pecanex-like 3 (Drosophila) Q9H6A9 Membrane; Multi-pass membrane protein (Potential). nucleus 15 14 nucleus nucleus Bilateria Bilateria Eukaryota PCNXL4 HGNC:20349 pecanex-like 4 (Drosophila) Q63HM2 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 37 17 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Eukaryota PCOLCE HGNC:8738 procollagen C-endopeptidase enhancer Q15113 Secreted. Extracellular (GO:0005576) 12486138,12670942,16188874 secreted 100 0 secreted secreted Theria Chordata Cell.Organisms PCOLCE2 HGNC:8739 procollagen C-endopeptidase enhancer 2 Q9UKZ9 Secreted (Probable). Extracellular (GO:0005576) 12063410 secreted 34 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms PCP2 HGNC:30209 Purkinje cell protein 2 Q8IVA1 Cytoplasm (GO:0005737) 10196137 cytoplasm 59 0 cytoplasm cytoplasm Theria Theria Bilateria PCP4 HGNC:8742 Purkinje cell protein 4 P48539 nucleus 36 0 nucleus nucleus Theria Euteleostomi Euteleostomi PCP4L1 HGNC:20448 Purkinje cell protein 4 like 1 A6NKN8 nucleus 46 0 nucleus nucleus NA NA Eutheria PCSK1 HGNC:8743 proprotein convertase subtilisin/kexin type 1 P29120 Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules. Extracellular (GO:0005576) 8916141 golgi apparatus membrane 41 0 secreted secreted Euteleostomi Opisthokonta Cell.Organisms PCSK1N HGNC:17301 proprotein convertase subtilisin/kexin type 1 inhibitor Q9UHG2 Secreted (By similarity). Golgi apparatus, trans-Golgi network (By similarity). Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease). Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasmic vesicle (GO:0016023) 10632593,10632593,10632593 secreted 27 0 nucleus. secreted multiple Eutheria Eutheria Eutheria PCSK2 HGNC:8744 proprotein convertase subtilisin/kexin type 2 P16519 Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules. golgi apparatus membrane 36 0 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms PCSK4 HGNC:8746 proprotein convertase subtilisin/kexin type 4 Q6UW60 Membrane; Single-pass membrane protein (Potential). Cytoplasm (GO:0005737) golgi apparatus membrane 41 1 golgi apparatus membrane golgi apparatus membrane Bilateria Opisthokonta Cell.Organisms PCSK5 HGNC:8747 proprotein convertase subtilisin/kexin type 5 Q92824 Isoform PC6A: Secreted. Isoform PC6B: Endomembrane system; Single- pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes (By similarity). Secretory granule (GO:0030141) 8947550 golgi apparatus membrane 40 1 endomembrane system. secreted multiple Bilateria Opisthokonta Cell.Organisms PCSK6 HGNC:8569 proprotein convertase subtilisin/kexin type 6 P29122 Isoform PACE4A-I: Secreted. Isoform PACE4A-II: Secreted. Isoform PACE4C: Endoplasmic reticulum. Isoform PACE4CS: Endoplasmic reticulum. Isoform PACE4E-I: Endomembrane system; Peripheral membrane protein. Isoform PACE4E-II: Endomembrane system; Peripheral membrane protein. Isoform PACE4B: Secreted. Extracellular matrix (GO:0005578);Endoplasmic reticulum (GO:0005783) 12535616/8906861 golgi apparatus membrane 44 0 endoplasmic reticulum. secreted multiple Bilateria Opisthokonta Cell.Organisms PCSK7 HGNC:8748 proprotein convertase subtilisin/kexin type 7 Q16549 Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Seems to be localized intracellularly to the trans Golgi network (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 12084516,11104692,10964928 golgi apparatus membrane 85 2 cytoplasm. golgi apparatus multiple Deuterostomia Opisthokonta Cell.Organisms PCSK9 HGNC:20001 proprotein convertase subtilisin/kexin type 9 Q8NBP7 Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and co-localizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Extracellular (GO:0005576) 17081983,17081983/12552133 secreted 16 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. lysosome. nucleus. secreted multiple Mammalia Cell.Organisms Cell.Organisms PCTP HGNC:8752 phosphatidylcholine transfer protein Q9UKL6 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10542325 cytoplasm 76 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms PCYOX1 HGNC:20588 prenylcysteine oxidase 1 Q9UHG3 Lysosome. Lysosome (GO:0005764) 10585463 secreted 31 0 lysosome lysosome Deuterostomia Cell.Organisms Eukaryota PCYOX1L HGNC:28477 prenylcysteine oxidase 1 like Q8NBM8 Secreted. secreted 100 0 secreted secreted Amniota Euteleostomi Eukaryota PCYT1A HGNC:8754 phosphate cytidylyltransferase 1, choline, alpha P49585 Cytoplasm, cytosol (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form (By similarity). Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 10480912,12052891,17081983,10480912,12052891,2833521,12052891,17081983 endoplasmic reticulum 73 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Cell.Organisms PCYT1B HGNC:8755 phosphate cytidylyltransferase 1, choline, beta Q9Y5K3 Endoplasmic reticulum. Cytoplasm (GO:0005737) 9593753 endoplasmic reticulum 100 0 cytoplasm. endoplasmic reticulum multiple Opisthokonta Eukaryota Cell.Organisms PCYT2 HGNC:8756 phosphate cytidylyltransferase 2, ethanolamine Q99447 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 9370320,9370320 endoplasmic reticulum 19 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Cell.Organisms Cell.Organisms PDAP1 HGNC:14634 PDGFA associated protein 1 Q13442 Extracellular (GO:0005576) 8780057 cytoplasm 53 0 secreted secreted Deuterostomia Eukaryota Eukaryota PDC HGNC:8759 phosducin P20941 Cytoplasm, cytosol. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Nucleus. Isoform 2: Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 9020189,12500174,8288259 cytoplasm 11 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota PDCD1 HGNC:8760 programmed cell death 1 Q15116 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 65 1 plasma membrane plasma membrane Eutheria Amniota Amniota PDCD10 HGNC:8761 programmed cell death 10 Q9BUL8 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells. mitochondrion 24 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa PDCD11 HGNC:13408 programmed cell death 11 Q14690 Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10229231,14624448 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PDCD1LG2 HGNC:18731 programmed cell death 1 ligand 2 Q9BQ51 Isoform 3: Secreted (Probable). Isoform 2: Endomembrane system; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12893276,15253154,12538684 plasma membrane 15 1 endomembrane system. plasma membrane. secreted multiple Mammalia Tetrapoda Bilateria PDCD2 HGNC:8762 programmed cell death 2 Q16342 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11854457,11854457 cytoplasm 15 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PDCD2L HGNC:28194 programmed cell death 2-like Q9BRP1 Cytoplasm (GO:0005737) cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PDCD4 HGNC:8763 programmed cell death 4 (neoplastic transformation inhibitor) Q53EL6 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 72 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota PDCD5 HGNC:8764 programmed cell death 5 O14737 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11741587,17081983,11741587,17081983 nucleus 80 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PDCD6 HGNC:8765 programmed cell death 6 O75340 Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Nucleoplasm (GO:0005654); Perinuclear region (GO:0048471) 11278427,14999017,11278427,15635413,14999017,14999017 cytoplasm 12 0 cytoplasm. nucleus multiple NA NA Cell.Organisms PDCD6IP HGNC:8766 programmed cell death 6 interacting protein Q8WUM4 Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Cytoskeleton (GO:0005856) 12034747,14999017,15557335,14999017,15557335 cytoplasm 28 0 cytoplasm. melanosome multiple Eukaryota Eukaryota Eukaryota PDCD7 HGNC:8767 programmed cell death 7 Q8N8D1 Nucleus (Potential). Nucleus (GO:0005634) secreted 26 0 secreted secreted Theria Deuterostomia Eumetazoa PDCL HGNC:8770 phosducin-like Q13371 Cytoplasm (GO:0005737) 10884381,17081983 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Opisthokonta Eukaryota PDCL2 HGNC:29524 phosducin-like 2 Q8N4E4 cytoplasm 50 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota PDCL3 HGNC:28860 phosducin-like 3 Q9H2J4 Cytoplasm. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 15371430,15371430 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDDC1 HGNC:26616 Parkinson disease 7 domain containing 1 Q8NB37 Secreted (Potential). cytoplasm 54 0 cytoplasm cytoplasm Amniota Chordata Cell.Organisms PDE10A HGNC:8772 phosphodiesterase 10A Q9Y233 Cytoplasm. Note=Located mostly to soluble cellular fractions. Cytoplasm (GO:0005737) 10441464 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms PDE11A HGNC:8773 phosphodiesterase 11A Q9HCR9 Cytoplasm, cytosol. Cytoplasm (GO:0005737) 10725373 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms PDE12 HGNC:25386 phosphodiesterase 12 Q6L8Q7 mitochondrion 57 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota PDE1A HGNC:8774 phosphodiesterase 1A, calmodulin-dependent P54750 Cytoplasm (GO:0005737) 11369604 cytoplasm 53 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDE1B HGNC:8775 phosphodiesterase 1B, calmodulin-dependent Q01064 Cytoplasm. Cytoplasm (GO:0005737) 8855339 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDE1C HGNC:8776 phosphodiesterase 1C, calmodulin-dependent 70kDa Q14123 Cytoplasm (GO:0005737) 11369604 cytoplasm 55 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDE2A HGNC:8777 phosphodiesterase 2A, cGMP-stimulated O00408 Cell membrane; Lipid-anchor. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10375378,10375378 cytoplasm 18 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms PDE3A HGNC:8778 phosphodiesterase 3A, cGMP-inhibited Q14432 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12154085,17081983,17081983 cytoplasm 18 6 cytoplasm. nucleus. plasma membrane multiple Euteleostomi Bilateria Eukaryota PDE3B HGNC:8779 phosphodiesterase 3B, cGMP-inhibited Q13370 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 10952971 cytoplasm 20 6 endoplasmic reticulum endoplasmic reticulum Euteleostomi Bilateria NA PDE4A HGNC:8780 phosphodiesterase 4A, cAMP-specific P27815 Isoform 1: Cytoplasm, perinuclear region. Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane. Isoform 4: Membrane; Peripheral membrane protein. Isoform 6: Cytoplasm, perinuclear region. Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic. Cytosol (GO:0005829); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12810716,8940140,9677330,8940140,7888306 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDE4B HGNC:8781 phosphodiesterase 4B, cAMP-specific Q07343 Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 9371714/12441002,14585965 cytoplasm 19 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDE4C HGNC:8782 phosphodiesterase 4C, cAMP-specific Q08493 Cell projection, cilium (By similarity). cytoplasm 18 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PDE4D HGNC:8783 phosphodiesterase 4D, cAMP-specific Q08499 Cytoplasm (By similarity). Membrane (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9371713,17081983,17081983 cytoplasm 25 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PDE4DIP HGNC:15580 phosphodiesterase 4D interacting protein Q5VU43 Golgi apparatus (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm. Nucleus. Golgi apparatus (GO:0005794); Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11134006,11134006,11374908,11374908 cytoplasm 17 0 cytoplasm. golgi apparatus. nucleus multiple Amniota Euteleostomi Opisthokonta PDE5A HGNC:8784 phosphodiesterase 5A, cGMP-specific O76074 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11358813,11358813 cytoplasm 96 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms PDE6A HGNC:8785 phosphodiesterase 6A, cGMP-specific, rod, alpha P16499 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) 1326553 cytoplasm 19 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PDE6B HGNC:8786 phosphodiesterase 6B, cGMP-specific, rod, beta P35913 Membrane; Lipid-anchor. Plasma membrane (GO:0005886) 1326553 cytoplasm 20 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PDE6C HGNC:8787 phosphodiesterase 6C, cGMP-specific, cone, alpha prime P51160 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PDE6D HGNC:8788 phosphodiesterase 6D, cGMP-specific, rod, delta O43924 Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023) 9712853,9712853 cytoplasm 9 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PDE6G HGNC:8789 phosphodiesterase 6G, cGMP-specific, rod, gamma P18545 Cytoplasm (GO:0005737) cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata PDE6H HGNC:8790 phosphodiesterase 6H, cGMP-specific, cone, gamma Q13956 nucleus 26 0 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi PDE7A HGNC:8791 phosphodiesterase 7A Q13946 Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions. Cytoplasm (GO:0005737) 12388353 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota PDE7B HGNC:8792 phosphodiesterase 7B Q9NP56 Cytoplasm (GO:0005737) cytoplasm 52 0 cytoplasm cytoplasm Tetrapoda Opisthokonta Eukaryota PDE8A HGNC:8793 phosphodiesterase 8A O60658 Membrane fraction (GO:0005624); Cytoplasm (GO:0005737) 12681444,12681444,17081983 cytoplasm 16 0 cytoplasm cytoplasm Chordata Opisthokonta Cell.Organisms PDE8B HGNC:8794 phosphodiesterase 8B O95263 Cytoplasm (GO:0005737); Membrane fraction (GO:0005624) 12681444,12681444 cytoplasm 15 0 cytoplasm cytoplasm Chordata Opisthokonta Cell.Organisms PDE9A HGNC:8795 phosphodiesterase 9A O76083 Isoform PDE9A1: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Isoform PDE9A2: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum. Isoform PDE9A17: Cytoplasm. Endoplasmic reticulum. cytoplasm 18 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota PDF HGNC:30012 peptide deformylase (mitochondrial) Q9HBH1 Mitochondrion (Potential). Mitochondrion (GO:0005739) 12924944 mitochondrion 27 0 mitochondrion mitochondrion NA NA Cell.Organisms PDGFA HGNC:8799 platelet-derived growth factor alpha polypeptide P04085 Secreted. Note=Released by platelets upon wounding. Extracellular (GO:0005576) 3754619 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa PDGFB HGNC:8800 platelet-derived growth factor beta polypeptide P01127 Secreted. Note=Released by platelets upon wounding. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1906887,10409733,10409733 secreted 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Eumetazoa PDGFC HGNC:8801 platelet derived growth factor C Q9NRA1 Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytosol (GO:0005829); Extracellular (GO:0005576) 16443219,16443219,16443219, secreted 35 0 cytoplasm. nucleus. secreted multiple Tetrapoda Euteleostomi Eumetazoa PDGFD HGNC:30620 platelet derived growth factor D Q9GZP0 Secreted. Note=Released by platelets upon wounding. Extracellular (GO:0005576) 11331882 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Eumetazoa PDGFRA HGNC:8803 platelet-derived growth factor receptor, alpha polypeptide P16234 Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly internalized and degraded. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8586421,8486649 plasma membrane 100 1 plasma membrane. secreted multiple Euteleostomi Bilateria Cell.Organisms PDGFRB HGNC:8804 platelet-derived growth factor receptor, beta polypeptide P09619 Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. Plasma membrane (GO:0005886) 9920285 plasma membrane 35 1 lysosome. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms PDGFRL HGNC:8805 platelet-derived growth factor receptor-like Q15198 Secreted (Probable). Plasma membrane (GO:0005886) 7898930 plasma membrane 10 0 secreted secreted Euteleostomi Euteleostomi Bilateria PDHA1 HGNC:8806 pyruvate dehydrogenase (lipoamide) alpha 1 P08559 Mitochondrion matrix. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 9003499,7573035,15598749,17081983 mitochondrion 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PDHA2 HGNC:8807 pyruvate dehydrogenase (lipoamide) alpha 2 P29803 Mitochondrion matrix. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11577086,17081983,17081983 mitochondrion 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PDHB HGNC:8808 pyruvate dehydrogenase (lipoamide) beta P11177 Mitochondrion matrix. Mitochondrion (GO:0005739) 11577086,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PDHX HGNC:21350 pyruvate dehydrogenase complex, component X O00330 Mitochondrion matrix. Mitochondrion (GO:0005739) 9399911 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms PDIA2 HGNC:14180 protein disulfide isomerase family A, member 2 Q13087 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) 8561901 endoplasmic reticulum 30 0 endoplasmic reticulum endoplasmic reticulum Theria Euteleostomi Cell.Organisms PDIA3 HGNC:4606 protein disulfide isomerase family A, member 3 P30101 Endoplasmic reticulum lumen (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) ,10436013,15561729,18029348,,12060494,12060494,15598749 endoplasmic reticulum 24 0 cytoplasm. endoplasmic reticulum. melanosome. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms PDIA4 HGNC:30167 protein disulfide isomerase family A, member 4 P13667 Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 12475965,1318337,15598749 endoplasmic reticulum 22 0 endoplasmic reticulum. melanosome. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms PDIA5 HGNC:24811 protein disulfide isomerase family A, member 5 Q14554 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783) 7556671 endoplasmic reticulum 18 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Bilateria Cell.Organisms PDIA6 HGNC:30168 protein disulfide isomerase family A, member 6 Q15084 Endoplasmic reticulum lumen (By similarity). Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Endoplasmic reticulum lumen (GO:0005788); Extracellular (GO:0005576); Mitochondrion (GO:0005739) 7590364,17215244,16188874,15598749 endoplasmic reticulum 22 0 endoplasmic reticulum. melanosome. mitochondrion. secreted multiple Eukaryota Cell.Organisms Cell.Organisms PDIK1L HGNC:18981 PDLIM1 interacting kinase 1 like Q8N165 Nucleus. Nucleus (GO:0005634) 14631099 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms PDILT HGNC:27338 protein disulfide isomerase-like, testis expressed Q8N807 Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783) 15475357 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Tetrapoda Euteleostomi Eukaryota PDK1 HGNC:8809 pyruvate dehydrogenase kinase, isozyme 1 Q15118 Mitochondrion matrix. Mitochondrion (GO:0005739); Extracellular (GO:0005576) 7499431,14718574 mitochondrion 100 0 mitochondrion. secreted multiple Euteleostomi Bilateria Cell.Organisms PDK2 HGNC:8810 pyruvate dehydrogenase kinase, isozyme 2 Q15119 Mitochondrion matrix. Mitochondrion (GO:0005739) 12573248,11701428 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms PDK3 HGNC:8811 pyruvate dehydrogenase kinase, isozyme 3 Q15120 Mitochondrion matrix. Mitochondrion (GO:0005739) 7499431 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Opisthokonta Cell.Organisms PDK4 HGNC:8812 pyruvate dehydrogenase kinase, isozyme 4 Q16654 Mitochondrion matrix. Mitochondrion (GO:0005739) 12573248,11701428 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms PDLIM1 HGNC:2067 PDZ and LIM domain 1 O00151 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associates with the actin stress fibers (By similarity). Cytoplasm (GO:0005737) 11973348 cytoplasm 87 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta PDLIM2 HGNC:13992 PDZ and LIM domain 2 (mystique) Q96JY6 Cytoplasm. Nucleus. Isoform 1: Cytoplasm, cytoskeleton. Isoform 2: Cytoplasm, cytoskeleton. Isoform 3: Nucleus. Cytoskeleton (GO:0005856); Nucleus (GO:0005634);Cytoskeleton (GO:0005856) 15659642,15659642/15659642 cytoplasm 97 0 cytoplasm. nucleus multiple Human Euteleostomi Holozoa PDLIM3 HGNC:20767 PDZ and LIM domain 3 Q53GG5 Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms PDLIM4 HGNC:16501 PDZ and LIM domain 4 P50479 Cytoplasm (GO:0005737) cytoplasm 34 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota PDLIM5 HGNC:17468 PDZ and LIM domain 5 Q96HC4 Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm (By similarity). Note=Detected both at presynaptic and postsynaptic sites (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8940095,17081983,8940095,17081983 cytoplasm 38 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota PDLIM7 HGNC:22958 PDZ and LIM domain 7 (enigma) Q9NR12 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Co-localizes with TBX4 and TBX5 to actin filaments (By similarity). Cytoskeleton (GO:0005856); Nucleolus (GO:0005730) 9528800,15635413 cytoplasm 93 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PDP1 HGNC:9279 pyruvate dehyrogenase phosphatase catalytic subunit 1 Q9P0J1 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 9651365 mitochondrion 98 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota PDP2 HGNC:30263 pyruvate dehyrogenase phosphatase catalytic subunit 2 Q9P2J9 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) mitochondrion 80 0 mitochondrion mitochondrion Euteleostomi Opisthokonta Eukaryota PDPK1 HGNC:8816 3-phosphoinositide dependent protein kinase 1 O15530 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non- neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation. Nucleus (GO:0005634);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 17081983/9895304,11481331,11481331,9895304 nucleus 21 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PDPN HGNC:29602 podoplanin Q86YL7 Membrane; Single-pass type I membrane protein (By similarity). Cell projection, filopodium membrane; Single-pass type I membrane protein (By similarity). Cell projection, lamellipodium membrane; Single-pass type I membrane protein (By similarity). Cell projection, microvillus membrane; Single-pass type I membrane protein (By similarity). Cell projection, ruffle membrane; Single-pass type I membrane protein (By similarity). Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles (By similarity). Plasma membrane (GO:0005886) 9651190,10393083 plasma membrane 61 1 plasma membrane plasma membrane Amniota Amniota Amniota PDPR HGNC:30264 pyruvate dehydrogenase phosphatase regulatory subunit Q8NCN5 Mitochondrion matrix (By similarity). mitochondrion 16 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms PDRG1 HGNC:16119 p53 and DNA-damage regulated 1 Q9NUG6 Cytoplasm (Potential). Cytoplasm (GO:0005737) 14562055 cytoplasm 38 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PDS5A HGNC:29088 PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) Q29RF7 Nucleus. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 15019998,15598749 nucleus 100 0 mitochondrion. nucleus multiple Opisthokonta Eukaryota Eukaryota PDS5B HGNC:20418 PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) Q9NTI5 Nucleus (By similarity). Nucleus (GO:0005634) 12072405 nucleus 96 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota PDSS1 HGNC:17759 prenyl (decaprenyl) diphosphate synthase, subunit 1 Q5T2R2 Mitochondrion (Potential). Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783) 8119922,8226825 mitochondrion 26 0 endoplasmic reticulum. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms PDSS2 HGNC:23041 prenyl (decaprenyl) diphosphate synthase, subunit 2 Q86YH6 Mitochondrion (Potential). Mitochondrion (GO:0005739) 16582907 mitochondrion 15 0 mitochondrion mitochondrion Deuterostomia Bilateria NA PDX1 HGNC:6107 pancreatic and duodenal homeobox 1 P52945 Nucleus. Cytoplasm, cytosol (By similarity). Nucleus (GO:0005634) 8954967 nucleus 67 0 nucleus nucleus Chordata Chordata Metazoa PDXDC1 HGNC:28995 pyridoxal-dependent decarboxylase domain containing 1 Q6P996 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 64 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms PDXK HGNC:8819 pyridoxal (pyridoxine, vitamin B6) kinase O00764 Cytoplasm. Cytoplasm (GO:0005737) 8510562 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PDXP HGNC:30259 pyridoxal (pyridoxine, vitamin B6) phosphatase Q96GD0 Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. mitochondrion 22 0 cytoplasm cytoplasm NA NA Cell.Organisms PDYN HGNC:8820 prodynorphin P01213 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10871647,10871647 secreted 100 0 cytoplasm. secreted multiple Theria Euteleostomi Craniata PDZD11 HGNC:28034 PDZ domain containing 11 Q5EBL8 Isoform 2: Secreted (Potential). Isoform 1: Cytoplasm. cytoplasm 27 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Holozoa PDZD2 HGNC:18486 PDZ domain containing 2 O15018 Nucleus (By similarity). Cytoplasm. Endoplasmic reticulum. Processed PDZ domain-containing protein 2: Secreted (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12671685,12671685,12671685,11289102 cytoplasm 18 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Euteleostomi Euteleostomi Holozoa PDZD3 HGNC:19891 PDZ domain containing 3 Q86UT5 Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells. Plasma membrane (GO:0005886) 11950846 cytoplasm 29 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PDZD4 HGNC:21167 PDZ domain containing 4 Q76G19 Cytoplasm, cell cortex. Note=Mainly localized under the plasma membrane. cytoplasm 27 0 cytoplasm cytoplasm Euteleostomi Bilateria NA PDZD7 HGNC:26257 PDZ domain containing 7 Q9H5P4 Cell projection, cilium. Nucleus. cytoplasm 16 0 nucleus nucleus Mammalia Euteleostomi Holozoa PDZD8 HGNC:26974 PDZ domain containing 8 Q8NEN9 Nucleus (GO:0005634) 17081983 cytoplasm 24 0 nucleus nucleus Amniota Bilateria Opisthokonta PDZD9 HGNC:28740 PDZ domain containing 9 Q8IXQ8 cytoplasm 70 0 cytoplasm cytoplasm Mammalia Mammalia Metazoa PDZK1 HGNC:8821 PDZ domain containing 1 Q5T2W1 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity). Plasma membrane (GO:0005886) 9461128,11051556,14531806 nucleus 26 0 nucleus nucleus Chordata Bilateria NA PDZK1IP1 HGNC:16887 PDZK1 interacting protein 1 Q13113 Membrane; Single-pass membrane protein. Plasma membrane (GO:0005886) 9461128 secreted 35 1 plasma membrane plasma membrane Theria Euteleostomi Amniota PDZRN3 HGNC:17704 PDZ domain containing ring finger 3 Q9UPQ7 nucleus 29 0 nucleus nucleus Euteleostomi Bilateria Eukaryota PDZRN4 HGNC:30552 PDZ domain containing ring finger 4 Q6ZMN7 cytoplasm 42 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota PEA15 HGNC:8822 phosphoprotein enriched in astrocytes 15 Q15121 Cytoplasm. Note=Associated with microtubules. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11702783,10493725,10926929,11702783 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Deuterostomia Bilateria PEAK1 HGNC:29431 pseudopodium-enriched atypical kinase 1 Q9H792 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Colocalizes with F-actin in serum-rich medium. Actin colocalization is reduced during serum starvation. nucleus 23 0 cytoplasm cytoplasm NA NA Metazoa PEAR1 HGNC:33631 platelet endothelial aggregation receptor 1 Q5VY43 Cell membrane; Single-pass membrane protein (Potential). Note=Detected on the cell surface in resting platelets. plasma membrane 37 1 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota PEBP1 HGNC:8630 phosphatidylethanolamine binding protein 1 P30086 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8738137,17081983,11034991 cytoplasm 97 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PEBP4 HGNC:28319 phosphatidylethanolamine-binding protein 4 Q96S96 Lysosome. Cytoplasm (GO:0005737); Lysosome (GO:0005764); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 15302887,15302887,15302887,15302887 cytoplasm 21 0 cytoplasm. lysosome. nucleus multiple Theria Eukaryota Eukaryota PECAM1 HGNC:8823 platelet/endothelial cell adhesion molecule 1 P16284 Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Plasma membrane (GO:0005886) 12610627 plasma membrane 5 1 plasma membrane plasma membrane NA NA Eumetazoa PECR HGNC:18281 peroxisomal trans-2-enoyl-CoA reductase Q9BY49 Peroxisome. Peroxisome (GO:0005777) 11669066 peroxisome 100 0 peroxisome peroxisome Deuterostomia Cell.Organisms Cell.Organisms PEF1 HGNC:30009 penta-EF-hand domain containing 1 Q9UBV8 Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated in the presence of Ca(2+). Cytoplasm (GO:0005737) 11278427 nucleus 35 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PEG10 HGNC:14005 paternally expressed 10 Q86TG7 Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (H) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12810624,14576465,12810624,14576465 nucleus 18 0 cytoplasm. nucleus multiple NA NA Opisthokonta PEG3 HGNC:8826 paternally expressed 3 Q9GZU2 Nucleus (By similarity). Cytoplasm (By similarity). Nucleus (GO:0005634) 11260267 nucleus 11 0 nucleus nucleus NA NA Eukaryota PELI1 HGNC:8827 pellino E3 ubiquitin protein ligase 1 Q96FA3 nucleus 30 0 nucleus nucleus Bilateria Bilateria Opisthokonta PELI2 HGNC:8828 pellino E3 ubiquitin protein ligase family member 2 Q9HAT8 nucleus 32 0 nucleus nucleus Bilateria Bilateria Opisthokonta PELI3 HGNC:30010 pellino E3 ubiquitin protein ligase family member 3 Q8N2H9 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta PELO HGNC:8829 pelota homolog (Drosophila) Q9BRX2 Nucleus (Potential). Cytoplasm (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) ,15635413,17081983 cytoplasm 36 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PELP1 HGNC:30134 proline, glutamate and leucine rich protein 1 Q8IZL8 Nucleus, nucleoplasm (By similarity). Nucleus. Cytoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11481323,15561729,11790298 secreted 24 0 cytoplasm. nucleus multiple NA NA Eumetazoa PEMT HGNC:8830 phosphatidylethanolamine N-methyltransferase Q9UBM1 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Mitochondrion membrane; Multi-pass membrane protein (Potential). Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria (By similarity). Mitochondrial membrane (GO:0005740); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 12431977,12431977,12431977,6830234,12431977,12431977 endoplasmic reticulum membrane 35 5 endoplasmic reticulum. golgi apparatus. mitochondrion membrane. nucleus. plasma membrane multiple Euteleostomi Eukaryota Eukaryota PENK HGNC:8831 proenkephalin P01210 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1729392,7559749,7559749 secreted 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Craniata PEPD HGNC:8840 peptidase D P12955 Cytoplasm (GO:0005737) 9020526 mitochondrion 17 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PER1 HGNC:8845 period circadian clock 1 O15534 Nucleus (By similarity). Cytoplasm (By similarity). Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10848614,17081983,10848614,17081983 nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa PER2 HGNC:8846 period circadian clock 2 O15055 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 (By similarity). PML regulates its nuclear localization (By similarity). Nucleus (GO:0005634); Cytosol (GO:0005829) 9427249,7592751,17218255,17218255 nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa PER3 HGNC:8847 period circadian clock 3 P56645 Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10837028,10837028 nucleus 20 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa PERM1 HGNC:28208 PPARGC1 and ESRR induced regulator, muscle 1 Q5SV97 cytoplasm 13 1 cytoplasm cytoplasm Amniota Amniota Eukaryota PERP HGNC:17637 PERP, TP53 apoptosis effector Q96FX8 Cell junction, desmosome. Cell membrane; Multi-pass membrane protein (By similarity). Note=Associated with desmosomes (By similarity). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 14726658,10733530,10733530 golgi apparatus membrane 54 4 golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Bilateria PES1 HGNC:8848 pescadillo ribosomal biogenesis factor 1 O00541 Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Ribosome (GO:0005840) 11071894,15635413,11790298,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PET100 HGNC:40038 PET100 homolog (S. cerevisiae) P0DJ07 Membrane; Single-pass membrane protein (Potential). Mitochondrion (By similarity). Note=Localizes to a membrane-bound organelle. nucleus 27 1 nucleus nucleus NA NA Bilateria PET112 HGNC:8849 PET112 homolog (yeast) O75879 Mitochondrion. Mitochondrion (GO:0005739) 9878253 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PET117 HGNC:40045 PET117 homolog (S. cerevisiae) Q6UWS5 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion NA NA Holozoa PEX1 HGNC:8850 peroxisomal biogenesis factor 1 O43933 Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes. Cytoplasm (GO:0005737) 9588209 nucleus 22 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PEX10 HGNC:8851 peroxisomal biogenesis factor 10 O60683 Peroxisome membrane; Peripheral membrane protein (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Peroxisome (GO:0005777) 17081983,17081983/10837480,9683594,9700193 cytoplasm 36 2 cytoplasm. nucleus. peroxisome multiple Euteleostomi Eukaryota Eukaryota PEX11A HGNC:8852 peroxisomal biogenesis factor 11 alpha O75192 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 9792670 peroxisome membrane 100 1 peroxisome. peroxisome membrane multiple Euteleostomi Eukaryota Holozoa PEX11B HGNC:8853 peroxisomal biogenesis factor 11 beta O96011 Peroxisome membrane; Single-pass membrane protein. Peroxisome (GO:0005777) 9792670 peroxisome membrane 100 1 peroxisome. peroxisome membrane multiple Theria Bilateria NA PEX11G HGNC:20208 peroxisomal biogenesis factor 11 gamma Q96HA9 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 12559946,12417726 peroxisome membrane 100 3 peroxisome. peroxisome membrane multiple Bilateria Bilateria Holozoa PEX12 HGNC:8854 peroxisomal biogenesis factor 12 O00623 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 9792670 peroxisome membrane 100 2 peroxisome. peroxisome membrane multiple Eukaryota Eukaryota Eukaryota PEX13 HGNC:8855 peroxisomal biogenesis factor 13 Q92968 Peroxisome membrane; Single-pass membrane protein. Peroxisome (GO:0005777) 8858165 peroxisome membrane 100 3 peroxisome. peroxisome membrane multiple Opisthokonta Eukaryota Opisthokonta PEX14 HGNC:8856 peroxisomal biogenesis factor 14 O75381 Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side. Peroxisome (GO:0005777); Nucleus (GO:0005634) 10022913,16280322,17081983 nucleus 48 1 nucleus. peroxisome multiple Opisthokonta Opisthokonta Eukaryota PEX16 HGNC:8857 peroxisomal biogenesis factor 16 Q9Y5Y5 Peroxisome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Peroxisomal membrane (GO:0005778) 9837814,12223482,9922452 mitochondrion 8 4 peroxisomal membrane. peroxisome membrane multiple Opisthokonta Eukaryota Opisthokonta PEX19 HGNC:9713 peroxisomal biogenesis factor 19 P40855 Cytoplasm. Peroxisome membrane; Lipid- anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes. Peroxisome (GO:0005777); Cytoplasm (GO:0005737) 10051604,16280322,10051604,16280322 nucleus 69 0 cytoplasm. peroxisome multiple Eukaryota Eukaryota Eukaryota PEX2 HGNC:9717 peroxisomal biogenesis factor 2 P28328 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 10891359 peroxisome membrane 100 2 peroxisome. peroxisome membrane multiple Eukaryota Eukaryota Eukaryota PEX26 HGNC:22965 peroxisomal biogenesis factor 26 Q7Z412 Peroxisome membrane; Single-pass type II membrane protein. Peroxisome (GO:0005777) 12717447 peroxisome membrane 100 1 peroxisome. peroxisome membrane multiple Amniota Euteleostomi Eumetazoa PEX3 HGNC:8858 peroxisomal biogenesis factor 3 P56589 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777); Mitochondrion (GO:0005739) 9657383,15598749 peroxisome membrane 100 2 mitochondrion. peroxisome. peroxisome membrane multiple Opisthokonta Eukaryota Eukaryota PEX5 HGNC:9719 peroxisomal biogenesis factor 5 P50542 Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13). Cytoplasm (GO:0005737); Peroxisome (GO:0005777) 8991089,8991089 nucleus 10 0 cytoplasm. peroxisome multiple Eukaryota Eukaryota Cell.Organisms PEX5L HGNC:30024 peroxisomal biogenesis factor 5-like Q8IYB4 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Some fraction is membrane associated via its interaction with RAB8B (By similarity). Cytoplasm (GO:0005737) 11463335 cytoplasm 18 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms PEX6 HGNC:8859 peroxisomal biogenesis factor 6 Q13608 Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes. Cytoplasm (GO:0005737) 9588209 cytoplasm 23 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PEX7 HGNC:8860 peroxisomal biogenesis factor 7 O00628 Peroxisome. Cytoplasm. Peroxisome (GO:0005777); Cytoplasm (GO:0005737) 9472033,9472033 nucleus 12 0 cytoplasm. peroxisome multiple Eukaryota Eukaryota Cell.Organisms PF4 HGNC:8861 platelet factor 4 P02776 Secreted. Extracellular (GO:0005576) 8511754,7524669,14718574 secreted 100 0 secreted secreted Euarchontoglires Eutheria Craniata PF4V1 HGNC:8862 platelet factor 4 variant 1 P10720 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Catarrhini Catarrhini Craniata PFAS HGNC:8863 phosphoribosylformylglycinamidine synthase O15067 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 17081983 cytoplasm 23 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PFDN1 HGNC:8866 prefoldin subunit 1 O60925 Cytoplasm (GO:0005737) 11884745 cytoplasm 16 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota PFDN2 HGNC:8867 prefoldin subunit 2 Q9UHV9 Nucleus. Cytoplasm. Mitochondrion. cytoplasm 24 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota PFDN4 HGNC:8868 prefoldin subunit 4 Q9NQP4 Nucleus. Cytoplasm. Mitochondrion. Cytoplasm (GO:0005737) 11884745 cytoplasm 16 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota PFDN5 HGNC:8869 prefoldin subunit 5 Q99471 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9792694,11844794,11567024,9792694 cytoplasm 33 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PFDN6 HGNC:4926 prefoldin subunit 6 O15212 nucleus 98 0 nucleus nucleus Theria Eukaryota NA PFKFB1 HGNC:8872 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 P16118 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2540168,2540168 cytoplasm 13 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PFKFB2 HGNC:8873 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 O60825 Mitochondrion (GO:0005739) 7904197,11129574 cytoplasm 14 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PFKFB3 HGNC:8874 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Q16875 cytoplasm 15 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PFKFB4 HGNC:8875 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Q16877 cytoplasm 14 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PFKL HGNC:8876 phosphofructokinase, liver P17858 Cytoplasm (GO:0005737) 8931492 cytoplasm 32 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PFKM HGNC:8877 phosphofructokinase, muscle P08237 cytoplasm 31 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PFKP HGNC:8878 phosphofructokinase, platelet Q01813 Cytoplasm (GO:0005737) 17081983 cytoplasm 31 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PFN1 HGNC:8881 profilin 1 P07737 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12224553,16188874 cytoplasm 100 0 cytoplasm. secreted multiple Theria Theria Bilateria PFN2 HGNC:8882 profilin 2 P35080 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 3356709 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota PFN3 HGNC:18627 profilin 3 P60673 Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Actin cytoskeleton (GO:0015629) 11867228 cytoplasm 30 0 cytoplasm cytoplasm Theria Amniota Craniata PFN4 HGNC:31103 profilin family, member 4 Q8NHR9 Cytoplasm, cytoskeleton (By similarity). cytoplasm 19 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota PGA3 HGNC:8885 pepsinogen 3, group I (pepsinogen A) P0DJD8 Secreted. secreted 100 0 secreted secreted NA NA Cell.Organisms PGA4 HGNC:8886 pepsinogen 4, group I (pepsinogen A) P0DJD7 Secreted. secreted 100 0 secreted secreted NA NA Cell.Organisms PGA5 HGNC:8887 pepsinogen 5, group I (pepsinogen A) P0DJD9 Secreted. Extracellular (GO:0005576) 2797342 secreted 100 0 secreted secreted NA NA Cell.Organisms PGAM1 HGNC:8888 phosphoglycerate mutase 1 (brain) P18669 Cytoplasm (GO:0005737) 2822696 cytoplasm 43 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGAM2 HGNC:8889 phosphoglycerate mutase 2 (muscle) P15259 Cytoplasm (GO:0005737) 2822696 cytoplasm 43 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGAM4 HGNC:21731 phosphoglycerate mutase family member 4 Q8N0Y7 cytoplasm 40 0 cytoplasm cytoplasm NA NA NA PGAM5 HGNC:28763 phosphoglycerate mutase family member 5 Q96HS1 Mitochondrion outer membrane; Single-pass membrane protein. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus. Cytosol (GO:0005829) 15561729 mitochondrion membrane 100 0 cytoplasm. mitochondrion membrane multiple NA NA Cell.Organisms PGAP1 HGNC:25712 post-GPI attachment to proteins 1 Q75T13 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 14734546 endoplasmic reticulum membrane 87 9 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Eukaryota PGAP2 HGNC:17893 post-GPI attachment to proteins 2 Q9UHJ9 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) 10585768 endoplasmic reticulum membrane 32 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota PGAP3 HGNC:23719 post-GPI attachment to proteins 3 Q96FM1 Golgi apparatus membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Note=Mainly localizes to Golgi apparatus (Probable). Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 12460457,12460457 endoplasmic reticulum membrane 17 7 endoplasmic reticulum membrane. golgi apparatus membrane. plasma membrane multiple Opisthokonta Eukaryota Eukaryota PGBD1 HGNC:19398 piggyBac transposable element derived 1 Q96JS3 nucleus 24 2 nucleus nucleus Catarrhini Eukaryota Eukaryota PGBD2 HGNC:19399 piggyBac transposable element derived 2 Q6P3X8 nucleus 93 2 nucleus nucleus Theria Eukaryota Eukaryota PGBD3 HGNC:19400 piggyBac transposable element derived 3 Q8N328 nucleus 93 2 nucleus nucleus NA NA Eukaryota PGBD4 HGNC:19401 piggyBac transposable element derived 4 Q96DM1 nucleus 82 2 nucleus nucleus Human Eukaryota Eukaryota PGBD5 HGNC:19405 piggyBac transposable element derived 5 Q8N414 Membrane; Single-pass membrane protein (Potential). nucleus 16 2 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PGC HGNC:8890 progastricsin (pepsinogen C) P20142 Secreted. Extracellular (GO:0005576) 1280267 secreted 100 0 secreted secreted Tetrapoda Opisthokonta Cell.Organisms PGD HGNC:8891 phosphogluconate dehydrogenase P52209 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12498092 cytoplasm 92 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGF HGNC:8893 placental growth factor P49763 Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 1924389,1924389,1924389,1924389,12824270 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Mammalia Euteleostomi Eumetazoa PGGT1B HGNC:8895 protein geranylgeranyltransferase type I, beta subunit P53609 secreted 26 0 secreted secreted Opisthokonta Eukaryota Eukaryota PGK1 HGNC:8896 phosphoglycerate kinase 1 P00558 Cytoplasm. Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12488440,1533225,1837552,1533225,1837552,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms NA PGK2 HGNC:8898 phosphoglycerate kinase 2 P07205 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 6873461 cytoplasm 84 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGLS HGNC:8903 6-phosphogluconolactonase O95336 Cytoplasm (By similarity). cytoplasm 86 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGLYRP1 HGNC:8904 peptidoglycan recognition protein 1 O75594 Secreted. Cytoplasmic granule (By similarity). secreted 29 0 secreted secreted Theria Cell.Organisms Cell.Organisms PGLYRP2 HGNC:30013 peptidoglycan recognition protein 2 Q96PD5 Secreted. Membrane. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 15340057,14506276,16188874,11461926,15340057,14506276 secreted 27 0 secreted secreted Tetrapoda Bilateria Cell.Organisms PGLYRP3 HGNC:30014 peptidoglycan recognition protein 3 Q96LB9 Secreted. Integral to membrane (GO:0016021) 11461926 secreted 100 0 secreted secreted Theria Bilateria Cell.Organisms PGLYRP4 HGNC:30015 peptidoglycan recognition protein 4 Q96LB8 Secreted. secreted 100 0 secreted secreted Euarchontoglires Bilateria Cell.Organisms PGM1 HGNC:8905 phosphoglucomutase 1 P36871 Isoform 1: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8631316,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PGM2 HGNC:8906 phosphoglucomutase 2 Q96G03 Cytoplasm (By similarity). cytoplasm 49 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGM2L1 HGNC:20898 phosphoglucomutase 2-like 1 Q6PCE3 Cytoplasm (GO:0005737) 17081983 cytoplasm 54 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PGM3 HGNC:8907 phosphoglucomutase 3 O95394 Cytoplasm (GO:0005737) 508567 mitochondrion 31 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PGM5 HGNC:8908 phosphoglucomutase 5 Q15124 Cell junction, adherens junction. Cytoplasm, cytoskeleton. Note=Adherens-type cellular junctions. Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments. Plasma membrane (GO:0005886) 10867799 cytoplasm 58 0 cytoplasm cytoplasm Eukaryota Cell.Organisms NA PGP HGNC:8909 phosphoglycolate phosphatase A6NDG6 mitochondrion 27 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PGPEP1 HGNC:13568 pyroglutamyl-peptidase I Q9NXJ5 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12030812,12651114,2575716 cytoplasm 93 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms PGPEP1L HGNC:27080 pyroglutamyl-peptidase I-like A6NFU8 cytoplasm 38 0 cytoplasm cytoplasm Tetrapoda Bilateria NA PGR HGNC:8910 progesterone receptor P06401 Nucleus. Cytoplasm. Isoform A: Nucleus. Cytoplasm. Isoform 4: Mitochondrion outer membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11545730,2736623,17347654,11545730,2736623,8671234,17347654,15598749 nucleus 96 1 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Metazoa PGRMC1 HGNC:16090 progesterone receptor membrane component 1 O00264 Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Single- pass membrane protein (By similarity). Plasma membrane (GO:0005886) 17215244 secreted 30 1 plasma membrane plasma membrane Eukaryota Eukaryota Eukaryota PGRMC2 HGNC:16089 progesterone receptor membrane component 2 O15173 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 secreted 24 1 nucleus. plasma membrane multiple Eukaryota Eukaryota Eukaryota PGS1 HGNC:30029 phosphatidylglycerophosphate synthase 1 Q32NB8 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 11171073 mitochondrion 92 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms PHACTR1 HGNC:20990 phosphatase and actin regulator 1 Q9C0D0 Cytoplasm (By similarity). Cell junction, synapse (By similarity). Nucleus (By similarity). Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). Cytoplasm (GO:0005737) 15107502 nucleus 37 0 cytoplasm cytoplasm Human Euteleostomi Opisthokonta PHACTR2 HGNC:20956 phosphatase and actin regulator 2 O75167 Cytoplasm (GO:0005737) 15107502 nucleus 49 0 cytoplasm cytoplasm Euteleostomi Bilateria Opisthokonta PHACTR3 HGNC:15833 phosphatase and actin regulator 3 Q96KR7 Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12925532/12925532,12925532 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta PHACTR4 HGNC:25793 phosphatase and actin regulator 4 Q8IZ21 Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Perinuclear region (GO:0048471); Synapse (GO:0045202); Cytoplasm (GO:0005737) 15107502,15107502,17081983 nucleus 36 0 cytoplasm cytoplasm Chordata Chordata Opisthokonta PHAX HGNC:10241 phosphorylated adaptor for RNA export Q9H814 Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm. Note=Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10786834,15574332,10786834 nucleus 98 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota PHB HGNC:8912 prohibitin P35232 Mitochondrion inner membrane (By similarity). Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Nucleolus (GO:0005730); Extracellular (GO:0005576); Cytoplasm (GO:0005737) ,8591812,15598749,15250827,,8591812,12466959,16319068,11790298,15378209,7843414,11517187,16319068 mitochondrion membrane 44 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Cell.Organisms PHB2 HGNC:30306 prohibitin 2 Q99623 Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity). Note=Also cytoplasmic and nuclear (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 15173318,15598749,15140878,15140878,15140878,15561729 mitochondrion membrane 60 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms NA PHC1 HGNC:3182 polyhomeotic homolog 1 (Drosophila) P78364 Nucleus. Nucleus (GO:0005634) 9121482,9009205 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa PHC2 HGNC:3183 polyhomeotic homolog 2 (Drosophila) Q8IXK0 Nucleus. Nucleus (GO:0005634) 9121482 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa PHC3 HGNC:15682 polyhomeotic homolog 3 (Drosophila) Q8NDX5 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12167701,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Amniota Amniota Opisthokonta PHEX HGNC:8918 phosphate regulating endopeptidase homolog, X-linked P78562 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 10620182 plasma membrane 24 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms PHF1 HGNC:8919 PHD finger protein 1 O43189 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co- localizes with NEK6 in the centrosome. Nucleus (GO:0005634) nucleus 29 0 cytoplasm. nucleus multiple Theria Tetrapoda NA PHF10 HGNC:18250 PHD finger protein 10 Q8WUB8 Nucleus (By similarity). nucleus 40 0 nucleus nucleus Bilateria Bilateria Eukaryota PHF11 HGNC:17024 PHD finger protein 11 Q9UIL8 Nucleus. Nucleus (GO:0005634) 10508479 nucleus 100 0 nucleus nucleus Eutheria Euteleostomi Eukaryota PHF12 HGNC:20816 PHD finger protein 12 Q96QT6 Nucleus. Nucleus (GO:0005634) 11390640 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Eukaryota PHF13 HGNC:22983 PHD finger protein 13 Q86YI8 Nucleus. Nucleus, nucleoplasm. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta PHF14 HGNC:22203 PHD finger protein 14 O94880 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 38 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota PHF19 HGNC:24566 PHD finger protein 19 Q5T6S3 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 15563832,15563832/15563832 nucleus 100 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eukaryota PHF2 HGNC:8920 PHD finger protein 2 O75151 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10051327,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta Eukaryota PHF20 HGNC:16098 PHD finger protein 20 Q9BVI0 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PHF20L1 HGNC:24280 PHD finger protein 20-like 1 A8MW92 nucleus 40 0 nucleus nucleus Chordata Chordata Eukaryota PHF21A HGNC:24156 PHD finger protein 21A Q96BD5 Nucleus (By similarity). Nucleus (GO:0005634) 12032298,15325272 nucleus 93 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PHF21B HGNC:25161 PHD finger protein 21B Q96EK2 nucleus 36 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota PHF23 HGNC:28428 PHD finger protein 23 Q9BUL5 nucleus 46 0 nucleus nucleus Theria Theria Opisthokonta PHF3 HGNC:8921 PHD finger protein 3 Q92576 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11856869,11464277,17081983,17081983 nucleus 33 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta Eukaryota PHF5A HGNC:18000 PHD finger protein 5A Q7RTV0 Nucleus (By similarity). Nucleus speckle (By similarity). Nucleus (GO:0005634) 12054543 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PHF6 HGNC:18145 PHD finger protein 6 Q8IWS0 Nucleus. Nucleus, nucleolus. Note=Nuclear, it particularly localizes to the nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleolus (GO:0005730); Nucleus (GO:0005634) 17081983,17081983/15635413,12415272,12415272 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PHF7 HGNC:18458 PHD finger protein 7 Q9BWX1 Nucleus. Nucleus (GO:0005634) 11829468 nucleus 100 0 nucleus nucleus Amniota Bilateria Eukaryota PHF8 HGNC:20672 PHD finger protein 8 Q9UPP1 Nucleus. Nucleus, nucleolus. Note=Recruited to H3K4me3 sites on chromatin during interphase. Dissociates from chromatin when cells enter mitosis. Nucleus (GO:0005634) none,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Opisthokonta NA PHGDH HGNC:8923 phosphoglycerate dehydrogenase O43175 Extracellular (GO:0005576); Cytosol (GO:0005829) 11055895,15561729 mitochondrion 28 0 cytoplasm. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms PHGR1 HGNC:37226 proline/histidine/glycine-rich 1 C9JFL3 endoplasmic reticulum membrane 38 0 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA NA PHIP HGNC:15673 pleckstrin homology domain interacting protein Q8WWQ0 Nucleus (By similarity). nucleus 94 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms PHKA1 HGNC:8925 phosphorylase kinase, alpha 1 (muscle) P46020 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10487978,10487978 nucleus 53 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria NA PHKA2 HGNC:8926 phosphorylase kinase, alpha 2 (liver) P46019 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). nucleus 57 0 nucleus nucleus Bilateria Bilateria Cell.Organisms PHKB HGNC:8927 phosphorylase kinase, beta Q93100 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). nucleus 45 0 nucleus nucleus Bilateria Bilateria Cell.Organisms PHKG1 HGNC:8930 phosphorylase kinase, gamma 1 (muscle) Q16816 Cytoplasm (GO:0005737) cytoplasm 26 2 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms PHKG2 HGNC:8931 phosphorylase kinase, gamma 2 (testis) P15735 Cytoplasm (GO:0005737) 7935363 cytoplasm 24 1 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms PHLDA1 HGNC:8933 pleckstrin homology-like domain, family A, member 1 Q8WV24 Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles. Cytoplasm (GO:0005737); Peroxisome (GO:0005777); Nucleolus (GO:0005730) 12738777,12384558,11369516,17024176,12738777,11369516 nucleus 36 0 cytoplasm. nucleus. peroxisome multiple Theria Euteleostomi Craniata PHLDA2 HGNC:12385 pleckstrin homology-like domain, family A, member 2 Q53GA4 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737) 12032310,12374806 nucleus 44 0 cytoplasm cytoplasm Human Human Deuterostomia PHLDA3 HGNC:8934 pleckstrin homology-like domain, family A, member 3 Q9Y5J5 Cytoplasm. Membrane; Peripheral membrane protein. mitochondrion 16 0 cytoplasm cytoplasm Mammalia Deuterostomia Deuterostomia PHLDB1 HGNC:23697 pleckstrin homology-like domain, family B, member 1 Q86UU1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PHLDB2 HGNC:29573 pleckstrin homology-like domain, family B, member 2 Q86SQ0 Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737) 12376540,12376540,12376540 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota PHLDB3 HGNC:30499 pleckstrin homology-like domain, family B, member 3 Q6NSJ2 nucleus 16 0 nucleus nucleus Mammalia Tetrapoda Eukaryota PHLPP1 HGNC:20610 PH domain and leucine rich repeat protein phosphatase 1 O60346 Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10570941,10570941,17081983,10570941 secreted 15 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Eukaryota Cell.Organisms PHLPP2 HGNC:29149 PH domain and leucine rich repeat protein phosphatase 2 Q6ZVD8 Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus. plasma membrane 16 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Cell.Organisms PHOSPHO1 HGNC:16815 phosphatase, orphan 1 Q8TCT1 cytoplasm 38 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PHOSPHO2 HGNC:28316 phosphatase, orphan 2 Q8TCD6 cytoplasm 56 0 cytoplasm cytoplasm Human Eukaryota Eukaryota PHOX2A HGNC:691 paired-like homeobox 2a O14813 Nucleus (By similarity). Nucleus (GO:0005634) 10644760 nucleus 34 0 nucleus nucleus Theria Euteleostomi Eukaryota PHOX2B HGNC:9143 paired-like homeobox 2b Q99453 Nucleus (By similarity). Nucleus (GO:0005634) 9374403 nucleus 33 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta PHPT1 HGNC:30033 phosphohistidine phosphatase 1 Q9NRX4 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12383260 cytoplasm 89 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PHRF1 HGNC:24351 PHD and ring finger domains 1 Q9P1Y6 nucleus 48 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota PHTF1 HGNC:8939 putative homeodomain transcription factor 1 Q9UMS5 Nucleus (Potential). Nucleus (GO:0005634) 1729229 plasma membrane 31 9 nucleus nucleus Deuterostomia Bilateria Holozoa PHTF2 HGNC:13411 putative homeodomain transcription factor 2 Q8N3S3 Nucleus (Potential). Integral to membrane (GO:0016021) plasma membrane 34 9 plasma membrane plasma membrane Deuterostomia Bilateria Holozoa PHYH HGNC:8940 phytanoyl-CoA 2-hydroxylase O14832 Peroxisome. Peroxisome (GO:0005777) 8954107 peroxisome 100 0 peroxisome peroxisome Deuterostomia Bilateria Cell.Organisms PHYHD1 HGNC:23396 phytanoyl-CoA dioxygenase domain containing 1 Q5SRE7 peroxisome 10 0 peroxisome peroxisome Bilateria Cell.Organisms Cell.Organisms PHYHIP HGNC:16865 phytanoyl-CoA 2-hydroxylase interacting protein Q92561 Cytoplasm (GO:0005737) 15694837 cytoplasm 22 0 cytoplasm cytoplasm Mammalia Bilateria Bilateria PHYHIPL HGNC:29378 phytanoyl-CoA 2-hydroxylase interacting protein-like Q96FC7 cytoplasm 29 0 cytoplasm cytoplasm Euteleostomi Bilateria Bilateria PHYKPL HGNC:28249 5-phosphohydroxy-L-lysine phospho-lyase Q8IUZ5 Mitochondrion (Potential). mitochondrion 27 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms PI15 HGNC:8946 peptidase inhibitor 15 O43692 Secreted. Extracellular (GO:0005576) 10362728 secreted 100 0 secreted secreted Theria Bilateria Cell.Organisms PI16 HGNC:21245 peptidase inhibitor 16 Q6UXB8 Membrane; Single-pass type I membrane protein (Potential). Extracellular space (GO:0005615) 15344909 secreted 24 1 secreted secreted Amniota Eukaryota Cell.Organisms PI3 HGNC:8947 peptidase inhibitor 3, skin-derived P19957 Secreted. Extracellular (GO:0005576) 7685029 secreted 100 0 secreted secreted Catarrhini Eutheria Bilateria PI4K2A HGNC:30031 phosphatidylinositol 4-kinase type 2 alpha Q9BTU6 Cytoplasm. Membrane (By similarity). Membrane raft. Cell projection, dendrite (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, synaptosome (By similarity). Mitochondrion (By similarity). Endosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Localized in neuronal cell body. Transported from neuronal cell body to neuron projections in a BLOC-1- and AP- 3-complexes-dependent manner. Enriched in neurite tips and neuron projections in a BLOC-1- and AP-3-complexes-dependent manner (By similarity). Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12650639,12324459,17081983,17081983 cytoplasm 30 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Deuterostomia Cell.Organisms Eukaryota PI4K2B HGNC:18215 phosphatidylinositol 4-kinase type 2 beta Q8TCG2 Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Endosome (GO:0005768) 12324459,11923287,12324459,11923287,12324459,11923287,12324459,12324459,11923287 cytoplasm 31 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus multiple Opisthokonta Eukaryota Eukaryota PI4KA HGNC:8983 phosphatidylinositol 4-kinase, catalytic, alpha P42356 Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Membrane fraction (GO:0005624) 8662589,1318025,17215244 nucleus 19 3 cytoplasm. golgi apparatus multiple NA NA Eukaryota PI4KB HGNC:8984 phosphatidylinositol 4-kinase, catalytic, beta Q9UBF8 Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 9584208,9405935,12324459,11277933,11277933,12324459,9148941,12324459,12324459/17081983 nucleus 34 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Eukaryota PIANP HGNC:25338 PILR alpha associated neural protein Q8IYJ0 Membrane; Single-pass type I membrane protein (Potential). nucleus 26 1 nucleus nucleus Amniota Amniota Tetrapoda PIAS1 HGNC:2752 protein inhibitor of activated STAT, 1 O75925 Nucleus speckle. Nucleus, PML body (By similarity). Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12393906,11451946,10628744,17540171,17081983,10628744,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Eukaryota PIAS2 HGNC:17311 protein inhibitor of activated STAT, 2 O75928 Nucleus speckle. Nucleus, PML body. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs). Nucleus (GO:0005634);Nucleus (GO:0005634);Nucleus (GO:0005634) 12716907/11477070,11877418,12716907/12193603 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota PIAS3 HGNC:16861 protein inhibitor of activated STAT, 3 Q9Y6X2 Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9388184,9388184 nucleus 54 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta NA PIAS4 HGNC:17002 protein inhibitor of activated STAT, 4 Q8N2W9 Nucleus, PML body. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies. Nucleus (GO:0005634) 11248056,12740389,12727872,11731474 nucleus 100 0 nucleus nucleus Euteleostomi Opisthokonta Eukaryota PIBF1 HGNC:23352 progesterone immunomodulatory binding factor 1 Q8WXW3 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 14634107,14634107,14634107 cytoplasm 9 0 cytoplasm. nucleus. secreted multiple Deuterostomia Eukaryota Eukaryota PICALM HGNC:15514 phosphatidylinositol binding clathrin assembly protein Q13492 Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to the nucleus in some cells. Plasma membrane (GO:0005886); Clathrin-coated vesicle (GO:0030136); Golgi apparatus (GO:0005794) 10436022,10436022,10436022 cytoplasm 15 0 golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota PICK1 HGNC:9394 protein interacting with PRKCA 1 Q9NRD5 Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Synapse (GO:0045202); Perinuclear region (GO:0048471); Basolateral membrane (GO:0016323) 7844141,7844141,7844141,10340301,15811349,7844141,10027300,16055064,15811349,15811349 secreted 21 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Bilateria Bilateria Holozoa PID1 HGNC:26084 phosphotyrosine interaction domain containing 1 Q7Z2X4 Cytoplasm. Cytoplasm (GO:0005737) 16815647 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria PIDD HGNC:16491 p53-induced death domain protein Q9HB75 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 15073321,10825539,16652156 secreted 21 0 cytoplasm. nucleus multiple Theria Chordata Cell.Organisms PIEZO1 HGNC:28993 piezo-type mechanosensitive ion channel component 1 Q92508 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,15561729,17081983,17081983 endoplasmic reticulum membrane 73 41 endoplasmic reticulum membrane. nucleus. plasma membrane multiple Bilateria Eukaryota Eukaryota PIEZO2 HGNC:26270 piezo-type mechanosensitive ion channel component 2 Q9H5I5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 68 41 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota PIF1 HGNC:26220 PIF1 5'-to-3' DNA helicase Q9H611 Nucleus. Isoform 4: Mitochondrion. nucleus 24 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PIFO HGNC:27009 primary cilia formation Q8TCI5 Cytoplasmic vesicle (By similarity). Golgi apparatus, trans-Golgi network (By similarity). Cytoplasm (By similarity). Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia (By similarity). At S phase, accumulates in vesicles and declines during mitosis (By similarity). secreted 18 0 secreted secreted Amniota Deuterostomia Metazoa PIGA HGNC:8957 phosphatidylinositol glycan anchor biosynthesis, class A P37287 Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane (GO:0005789) 8900170 endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms Cell.Organisms PIGB HGNC:8959 phosphatidylinositol glycan anchor biosynthesis, class B Q92521 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 8861954 endoplasmic reticulum membrane 100 11 endoplasmic reticulum. endoplasmic reticulum membrane multiple Mammalia Eukaryota Cell.Organisms PIGC HGNC:8960 phosphatidylinositol glycan anchor biosynthesis, class C Q92535 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane (GO:0005789) 8806613 endoplasmic reticulum membrane 16 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota PIGF HGNC:8962 phosphatidylinositol glycan anchor biosynthesis, class F Q07326 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789) 10781593 endoplasmic reticulum membrane 85 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota PIGG HGNC:25985 phosphatidylinositol glycan anchor biosynthesis, class G Q5H8A4 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15632136 endoplasmic reticulum membrane 100 15 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Cell.Organisms NA PIGH HGNC:8964 phosphatidylinositol glycan anchor biosynthesis, class H Q14442 Cytoplasm. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 8900170,8407896 cytoplasm 100 2 cytoplasm. endoplasmic reticulum multiple Opisthokonta Eukaryota Eukaryota PIGK HGNC:8965 phosphatidylinositol glycan anchor biosynthesis, class K Q92643 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783) 12616539 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Cell.Organisms PIGL HGNC:8966 phosphatidylinositol glycan anchor biosynthesis, class L Q9Y2B2 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 9188481,14742432,9188481 endoplasmic reticulum membrane 24 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Cell.Organisms Cell.Organisms PIGM HGNC:18858 phosphatidylinositol glycan anchor biosynthesis, class M Q9H3S5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11226175 endoplasmic reticulum membrane 100 10 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Eukaryota PIGN HGNC:8967 phosphatidylinositol glycan anchor biosynthesis, class N O95427 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789); Microsome (GO:0005792) 10574991,10574991 endoplasmic reticulum membrane 84 16 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Eukaryota Cell.Organisms PIGO HGNC:23215 phosphatidylinositol glycan anchor biosynthesis, class O Q8TEQ8 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 10781593 endoplasmic reticulum membrane 82 15 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Cell.Organisms PIGP HGNC:3046 phosphatidylinositol glycan anchor biosynthesis, class P P57054 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 10814524 endoplasmic reticulum membrane 20 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota PIGQ HGNC:14135 phosphatidylinositol glycan anchor biosynthesis, class Q Q9BRB3 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 10373468 plasma membrane 71 9 endoplasmic reticulum endoplasmic reticulum Opisthokonta Eukaryota Eukaryota PIGR HGNC:8968 polymeric immunoglobulin receptor P01833 Cell membrane; Single-pass type I membrane protein. Secretory component: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 3197448,11030626,7107583 plasma membrane 29 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Bilateria PIGS HGNC:14937 phosphatidylinositol glycan anchor biosynthesis, class S Q96S52 Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome (GO:0005792); Mitochondrion (GO:0005739) 11483512,15598749 endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane. mitochondrion multiple Opisthokonta Eukaryota Eukaryota PIGT HGNC:14938 phosphatidylinositol glycan anchor biosynthesis, class T Q969N2 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783) 11483512 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Eukaryota Eukaryota PIGU HGNC:15791 phosphatidylinositol glycan anchor biosynthesis, class U Q9H490 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 15034568,15034568 endoplasmic reticulum membrane 58 11 endoplasmic reticulum. plasma membrane multiple Opisthokonta Eukaryota Eukaryota PIGV HGNC:26031 phosphatidylinositol glycan anchor biosynthesis, class V Q9NUD9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15623507 endoplasmic reticulum membrane 100 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Eukaryota PIGW HGNC:23213 phosphatidylinositol glycan anchor biosynthesis, class W Q7Z7B1 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 14517336 endoplasmic reticulum membrane 70 13 endoplasmic reticulum endoplasmic reticulum Opisthokonta Eukaryota NA PIGX HGNC:26046 phosphatidylinositol glycan anchor biosynthesis, class X Q8TBF5 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 15635094 endoplasmic reticulum membrane 76 1 endoplasmic reticulum endoplasmic reticulum Amniota Eukaryota Eukaryota PIGY HGNC:28213 phosphatidylinositol glycan anchor biosynthesis, class Y Q3MUY2 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Cell.Organisms Deuterostomia PIGZ HGNC:30596 phosphatidylinositol glycan anchor biosynthesis, class Z Q86VD9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15208306 endoplasmic reticulum membrane 100 13 endoplasmic reticulum. endoplasmic reticulum membrane multiple Amniota Eukaryota Eukaryota PIH1D1 HGNC:26075 PIH1 domain containing 1 Q9NWS0 cytoplasm 7 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota PIH1D2 HGNC:25210 PIH1 domain containing 2 Q8WWB5 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Eukaryota NA PIH1D3 HGNC:28570 PIH1 domain containing 3 Q9NQM4 nucleus 51 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota PIK3AP1 HGNC:30034 phosphoinositide-3-kinase adaptor protein 1 Q6ZUJ8 Cytoplasm (By similarity). Cell membrane (By similarity); Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737) 11163197 cytoplasm 43 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eumetazoa PIK3C2A HGNC:8971 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha O00443 Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes containing PtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with RNA-containing structures. According to PubMed:14563213, it is mainly cytoplasmic. Cytosol (GO:0005829) 16215232 cytoplasm 20 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota PIK3C2B HGNC:8972 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta O00750 Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis. Plasma membrane (GO:0005886) 9830063 plasma membrane 22 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Eukaryota PIK3C2G HGNC:8973 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma O75747 Membrane; Peripheral membrane protein (By similarity). Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9516481,9516481,9516481 secreted 18 0 golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota PIK3C3 HGNC:8974 phosphatidylinositol 3-kinase, catalytic subunit type 3 Q8NEB9 Midbody. Late endosome. nucleus 14 0 endosome endosome Eukaryota Eukaryota Eukaryota PIK3CA HGNC:8975 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha P42336 Plasma membrane (GO:0005886) 10213474 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PIK3CB HGNC:8976 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta P42338 Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export. cytoplasm 48 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota PIK3CD HGNC:8977 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta O00329 Cytoplasm. Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737) 12147247,12147247 cytoplasm 100 1 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PIK3CG HGNC:8978 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma P48736 Cytoplasm. Cell membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11416136,10488142,11259422 cytoplasm 21 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PIK3IP1 HGNC:24942 phosphoinositide-3-kinase interacting protein 1 Q96FE7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 36 1 secreted secreted Euteleostomi Euteleostomi Eukaryota PIK3R1 HGNC:8979 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) P27986 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10459020,9610355,16717100,17081983 cytoplasm 25 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota PIK3R2 HGNC:8980 phosphoinositide-3-kinase, regulatory subunit 2 (beta) O00459 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10459020,10459020 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa PIK3R3 HGNC:8981 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) Q92569 cytoplasm 23 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PIK3R4 HGNC:8982 phosphoinositide-3-kinase, regulatory subunit 4 Q99570 Late endosome. cytoplasm 18 0 endosome endosome Opisthokonta Eukaryota Cell.Organisms PIK3R5 HGNC:30035 phosphoinositide-3-kinase, regulatory subunit 5 Q8WYR1 Nucleus (By similarity). Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12507995,12507995 nucleus 62 0 nucleus nucleus Theria Chordata Holozoa PIK3R6 HGNC:27101 phosphoinositide-3-kinase, regulatory subunit 6 Q5UE93 Cytoplasm (By similarity). nucleus 67 0 nucleus nucleus Euteleostomi Euteleostomi NA PIKFYVE HGNC:23785 phosphoinositide kinase, FYVE finger containing Q9Y2I7 Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 14530284,15542851,15277528,9858586,14530284,15277528,9858586,15542851,17081983 cytoplasm 14 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PILRA HGNC:20396 paired immunoglobin-like type 2 receptor alpha Q9UKJ1 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 3: Secreted (Potential). Isoform 4: Secreted (Potential). Plasma membrane (GO:0005886) 10903717 plasma membrane 90 1 plasma membrane plasma membrane Eutheria Eutheria Eutheria PILRB HGNC:18297 paired immunoglobin-like type 2 receptor beta Q9UKJ0 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 10660620,12021780 plasma membrane 82 1 plasma membrane plasma membrane Eutheria Eutheria Eutheria PIM1 HGNC:8986 pim-1 oncogene P11309 Isoform 2: Cytoplasm. Nucleus. Isoform 1: Cell membrane. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10931201,16186805,2837645 cytoplasm 62 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms PIM2 HGNC:8987 pim-2 oncogene Q9P1W9 Cytoplasm (GO:0005737) cytoplasm 55 0 cytoplasm cytoplasm Theria Theria NA PIM3 HGNC:19310 pim-3 oncogene Q86V86 Cytoplasm. Cytoplasm (GO:0005737) 15540201 cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms PIN1 HGNC:8988 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Q13526 Nucleus. Nucleus speckle. Cytoplasm. Note=Co-localizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9299231,11988841,9200606,16476580,10888662 nucleus 48 0 cytoplasm. nucleus multiple Theria Cell.Organisms Cell.Organisms PIN4 HGNC:8992 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) Q9Y237 Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N- terminal domain that functions as non-cleavable mitochondrial targeting peptide. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12144781,12144781,10364457 nucleus 31 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms PINK1 HGNC:14581 PTEN induced putative kinase 1 Q9BXM7 Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol. Mitochondrion (GO:0005739) 15087508 cytoplasm 14 0 cytoplasm. mitochondrion. mitochondrion membrane multiple Amniota Bilateria Cell.Organisms PINLYP HGNC:44206 phospholipase A2 inhibitor and LY6/PLAUR domain containing A6NC86 Secreted (Potential). secreted 14 0 secreted secreted NA NA Tetrapoda PINX1 HGNC:30046 PIN2/TERF1 interacting, telomerase inhibitor 1 Q96BK5 Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE. nucleus 100 0 nucleus nucleus NA NA Eukaryota PIP HGNC:8993 prolactin-induced protein P12273 Secreted. Extracellular (GO:0005576) 3667631,16188874 secreted 100 0 secreted secreted Eutheria Mammalia Tetrapoda PIP4K2A HGNC:8997 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha P48426 Cell membrane (By similarity). Nucleus. Cytoplasm. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. cytoplasm 15 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota PIP4K2B HGNC:8998 phosphatidylinositol-5-phosphate 4-kinase, type II, beta P78356 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytosol (GO:0005829); Endoplasmic reticulum (GO:0005783) 9753329,14691457,9843587,14691457,14691457,14691457 cytoplasm 17 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Bilateria Eukaryota PIP4K2C HGNC:23786 phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Q8TBX8 Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity). cytoplasm 19 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota PIP5K1A HGNC:8994 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha Q99755 Cell membrane. Cytoplasm (By similarity). Nucleus speckle. Cell projection, ruffle. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Cytosol (GO:0005829); Microtubule (GO:0005874); Actin filament (GO:0005884) 11431481,11042212,10589680,11032811,17623810,11431481,12682053,10747863,11431481,11042212,11431481,11032811,11032811,12682053 cytoplasm 94 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota PIP5K1B HGNC:8995 phosphatidylinositol-4-phosphate 5-kinase, type I, beta O14986 Endomembrane system (By similarity). Note=Associated with membranes (By similarity). cytoplasm 59 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PIP5K1C HGNC:8996 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma O60331 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system. Cytoplasm. Cell junction, focal adhesion. Cell junction, adherens junction. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Cell projection, uropodium. Isoform 2: Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12847086,11604140,11604140,17290217 cytoplasm 64 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PIP5KL1 HGNC:28711 phosphatidylinositol-4-phosphate 5-kinase-like 1 Q5T9C9 Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures (By similarity). Cytoplasmic vesicle (GO:0016023) 14701839 cytoplasm 11 0 cytoplasm cytoplasm Chordata Chordata Eukaryota PIPOX HGNC:17804 pipecolic acid oxidase Q9P0Z9 Peroxisome. Peroxisome (GO:0005777) 10772957,10642506 peroxisome 100 0 peroxisome peroxisome Deuterostomia Cell.Organisms Cell.Organisms PIR HGNC:30048 pirin (iron-binding nuclear protein) O00625 Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. Nuclear matrix (GO:0016363) 9079676,14573596 mitochondrion 10 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms PIRT HGNC:37239 phosphoinositide-interacting regulator of transient receptor potential channels P0C851 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 1 2 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Olfactores PISD HGNC:8999 phosphatidylserine decarboxylase Q9UG56 Mitochondrion (By similarity). Mitochondrion (GO:0005739) 8870646 mitochondrion 83 1 mitochondrion mitochondrion NA NA Cell.Organisms PITHD1 HGNC:25022 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 Q9GZP4 cytoplasm 26 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PITPNA HGNC:9001 phosphatidylinositol transfer protein, alpha Q00169 Cytoplasm. Cytoplasm (GO:0005737) 7761838 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PITPNB HGNC:9002 phosphatidylinositol transfer protein, beta P48739 Cytoplasm (By similarity). Golgi apparatus (By similarity). Cytoplasm (GO:0005737) 1883207 cytoplasm 72 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PITPNC1 HGNC:21045 phosphatidylinositol transfer protein, cytoplasmic 1 Q9UKF7 Cytoplasm. Cytoplasm (GO:0005737) 10531358 cytoplasm 100 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota PITPNM1 HGNC:9003 phosphatidylinositol transfer protein, membrane-associated 1 O00562 Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Cleavage furrow. Midbody. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 12077336,12225667,12077336,12225667 cytoplasm 36 0 cytoplasm. golgi apparatus. lipid droplet multiple Bilateria Eukaryota Cell.Organisms PITPNM2 HGNC:21044 phosphatidylinositol transfer protein, membrane-associated 2 Q9BZ72 Endomembrane system; Peripheral membrane protein. cytoplasm 32 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PITPNM3 HGNC:21043 PITPNM family member 3 Q9BZ71 Endomembrane system; Peripheral membrane protein (Probable). Nucleus (GO:0005634) 10022914 cytoplasm 28 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms PITRM1 HGNC:17663 pitrilysin metallopeptidase 1 Q5JRX3 Mitochondrion matrix. Extracellular (GO:0005576) 10360838 mitochondrion 100 0 mitochondrion. secreted multiple Eukaryota Cell.Organisms Cell.Organisms PITX1 HGNC:9004 paired-like homeodomain 1 P78337 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12620797,11048804 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PITX2 HGNC:9005 paired-like homeodomain 2 Q99697 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/12130547 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota PITX3 HGNC:9006 paired-like homeodomain 3 O75364 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 98 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota PIWIL1 HGNC:9007 piwi-like RNA-mediated gene silencing 1 Q96J94 Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Also present in chromatoid body (By similarity). cytoplasm 94 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PIWIL2 HGNC:17644 piwi-like RNA-mediated gene silencing 2 Q8TC59 Cytoplasm (By similarity). Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity). Cytoplasm (GO:0005737) 14736746 cytoplasm 85 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PIWIL3 HGNC:18443 piwi-like RNA-mediated gene silencing 3 Q7Z3Z3 Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PIWIL4 HGNC:18444 piwi-like RNA-mediated gene silencing 4 Q7Z3Z4 Nucleus (By similarity). Cytoplasm (By similarity). Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). Cytoplasm (GO:0005737) cytoplasm 37 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PJA1 HGNC:16648 praja ring finger 1, E3 ubiquitin protein ligase Q8NG27 Cytoplasm (GO:0005737) 9393880 plasma membrane 38 0 cytoplasm cytoplasm Euarchontoglires Eutheria Eukaryota PJA2 HGNC:17481 praja ring finger 2, E3 ubiquitin protein ligase O43164 Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9393880,7623148,9393880,7623148 plasma membrane 32 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Tetrapoda Eukaryota Eukaryota PKD1 HGNC:9008 polycystic kidney disease 1 (autosomal dominant) P98161 Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity). Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8981910,8981910 secreted 24 11 cytoplasm. plasma membrane multiple Chordata Chordata Cell.Organisms PKD1L1 HGNC:18053 polycystic kidney disease 1 like 1 Q8TDX9 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11863367 plasma membrane 10 12 plasma membrane plasma membrane Mammalia Deuterostomia Holozoa PKD1L2 HGNC:21715 polycystic kidney disease 1-like 2 Q7Z442 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12782129 plasma membrane 33 11 plasma membrane plasma membrane Deuterostomia Deuterostomia Holozoa PKD1L3 HGNC:21716 polycystic kidney disease 1-like 3 Q7Z443 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 30 13 plasma membrane plasma membrane Deuterostomia Deuterostomia NA PKD2 HGNC:9009 polycystic kidney disease 2 (autosomal dominant) Q13563 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum. Cell projection, cilium (By similarity). Perinuclear region (GO:0048471); Plasma membrane (GO:0005886); Endoplasmic reticulum membrane (GO:0005789); Nucleus (GO:0005634) 12527301,9529618,11252306,12527301,17081983 plasma membrane 8 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus. plasma membrane multiple Bilateria Eukaryota Eukaryota PKD2L1 HGNC:9011 polycystic kidney disease 2-like 1 Q9P0L9 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11805156,12809519 plasma membrane 18 8 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota PKD2L2 HGNC:9012 polycystic kidney disease 2-like 2 Q9NZM6 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 33 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Amniota Holozoa PKDCC HGNC:25123 protein kinase domain containing, cytoplasmic Q504Y2 Golgi apparatus (By similarity). golgi apparatus 91 0 golgi apparatus golgi apparatus Euteleostomi Deuterostomia Eukaryota PKDREJ HGNC:9015 polycystin (PKD) family receptor for egg jelly Q9NTG1 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 8 13 plasma membrane plasma membrane Amniota Deuterostomia Holozoa PKHD1 HGNC:9016 polycystic kidney and hepatic disease 1 (autosomal recessive) P08F94 Membrane; Single-pass type I membrane protein (Probable). Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cell projection (GO:0042995) 12191969,14983006,15458427,11919560,14983006,15458427,14983006,15458427 plasma membrane 6 1 cytoplasm. plasma membrane multiple Deuterostomia Cell.Organisms Cell.Organisms PKHD1L1 HGNC:20313 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 Q86WI1 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 11 1 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms PKIA HGNC:9017 protein kinase (cAMP-dependent, catalytic) inhibitor alpha P61925 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7836431,7836431 cytoplasm 28 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Euteleostomi PKIB HGNC:9018 protein kinase (cAMP-dependent, catalytic) inhibitor beta Q9C010 Nucleus (GO:0005634) 10880337 nucleus 26 0 nucleus nucleus Eutheria Bilateria Bilateria PKIG HGNC:9019 protein kinase (cAMP-dependent, catalytic) inhibitor gamma Q9Y2B9 cytoplasm 38 0 cytoplasm cytoplasm Amniota Euteleostomi Euteleostomi PKLR HGNC:9020 pyruvate kinase, liver and RBC P30613 Cytoplasm (GO:0005737) 17081983 cytoplasm 38 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA PKM HGNC:9021 pyruvate kinase, muscle P14618 Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Extracellular (GO:0005576); Cytosol (GO:0005829) 2813362,12650930,16188874,16263121 cytoplasm 41 0 cytoplasm. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms PKMYT1 HGNC:29650 protein kinase, membrane associated tyrosine/threonine 1 Q99640 Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783);Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9001210,9001210/9001210,12912980,9001210,12912980 nucleus 18 1 endoplasmic reticulum. golgi apparatus multiple Opisthokonta Eukaryota Cell.Organisms PKN1 HGNC:9405 protein kinase N1 Q16512 Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8816775,8816775,17081983 cytoplasm 33 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Cell.Organisms PKN2 HGNC:9406 protein kinase N2 Q16513 Cytoplasm. Nucleus. Membrane (By similarity). Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634) 8910519,17081983,14718574,17081983 cytoplasm 34 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Cell.Organisms PKN3 HGNC:17999 protein kinase N3 Q6P5Z2 Nucleus. Cytoplasm, perinuclear region. Note=Nuclear and perinuclear Golgi region. Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 10441506,10441506 cytoplasm 29 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms PKNOX1 HGNC:9022 PBX/knotted 1 homeobox 1 P55347 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9366523,9482740,10215622,10215622 nucleus 54 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota PKNOX2 HGNC:16714 PBX/knotted 1 homeobox 2 Q96KN3 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11972344,15339927,11972344,15339927 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota PKP1 HGNC:9023 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) Q13835 Isoform 1: Nucleus. Cell junction, desmosome. Nucleus. Nucleus (GO:0005634); Desmosome (GO:0030057) 11790773,15988759,7527055 nucleus 20 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PKP2 HGNC:9024 plakophilin 2 Q99959 Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes. Integral to membrane (GO:0016021); Plasma membrane (GO:0005886); Desmosome (GO:0030057); Nucleus (GO:0005634);Nucleus (GO:0005634) 8922383,8922383,8922383,8922383,11416169,15561729/11416169 secreted 14 0 nucleus nucleus Amniota Euteleostomi Opisthokonta PKP3 HGNC:9025 plakophilin 3 Q9Y446 Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10374265,10381383,19059367 nucleus 18 1 nucleus. plasma membrane multiple Euarchontoglires Euteleostomi Eukaryota PKP4 HGNC:9026 plakophilin 4 Q99569 Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Desmosome (GO:0030057); Nucleus (GO:0005634) 17081983,17081983/8937994,12047349,8937994,8937994,11711544,12370826,17081983 secreted 27 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota PLA1A HGNC:17661 phospholipase A1 member A Q53H76 Secreted (Potential). Extracellular (GO:0005576) 8999922 secreted 19 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms PLA2G10 HGNC:9029 phospholipase A2, group X O15496 Secreted. Extracellular (GO:0005576) 9188469 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Eumetazoa PLA2G12A HGNC:18554 phospholipase A2, group XIIA Q9BZM1 Secreted. Cytoplasm. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11031251,11278438,11278438 secreted 31 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Bilateria Eukaryota PLA2G12B HGNC:18555 phospholipase A2, group XIIB Q9BX93 Secreted. Extracellular (GO:0005576) 14516201 secreted 100 0 secreted secreted Euteleostomi Bilateria Opisthokonta PLA2G15 HGNC:17163 phospholipase A2, group XV Q8NCC3 Lysosome (By similarity). Secreted. Extracellular (GO:0005576); Lysosome (GO:0005764) 10092508,11790796 secreted 40 2 lysosome. secreted multiple Bilateria Eukaryota Cell.Organisms PLA2G16 HGNC:17825 phospholipase A2, group XVI P53816 Cytoplasm. Cytoplasm, perinuclear region (By similarity). Membrane; Single-pass membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17374643,17374643 mitochondrion membrane 11 1 cytoplasm. nucleus multiple Eutheria Mammalia Cell.Organisms PLA2G1B HGNC:9030 phospholipase A2, group IB (pancreas) P04054 Secreted. Note=secreted from pancreatic acinar cells in its inactive form. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12501175,11025364,10964913 secreted 100 0 cytoplasm. secreted multiple Bilateria Bilateria Eumetazoa PLA2G2A HGNC:9031 phospholipase A2, group IIA (platelets, synovial fluid) P14555 Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) 9811056 secreted 41 0 cytoplasm cytoplasm Amniota Amniota Eumetazoa PLA2G2C HGNC:9032 phospholipase A2, group IIC Q5R387 Secreted (Potential). secreted 25 0 secreted secreted Theria Theria Eumetazoa PLA2G2D HGNC:9033 phospholipase A2, group IID Q9UNK4 Secreted (Potential). Extracellular (GO:0005576) 10455175 secreted 38 0 secreted secreted Theria Deuterostomia Eumetazoa PLA2G2E HGNC:13414 phospholipase A2, group IIE Q9NZK7 Secreted. Extracellular (GO:0005576) 10681567 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Eumetazoa PLA2G2F HGNC:30040 phospholipase A2, group IIF Q9BZM2 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11112443,11877435 secreted 100 0 secreted secreted Mammalia Mammalia Eumetazoa PLA2G3 HGNC:17934 phospholipase A2, group III Q9NZ20 Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Extracellular (GO:0005576) 10713052,12522102 secreted 34 0 cytoplasm. secreted multiple Euteleostomi Bilateria Eumetazoa PLA2G4A HGNC:9035 phospholipase A2, group IVA (cytosolic, calcium-dependent) P47712 Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11416127,11416127 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota PLA2G4B HGNC:9036 phospholipase A2, group IVB (cytosolic) P0C869 Cytoplasm, cytosol. Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion. cytoplasm 30 0 cytoplasm cytoplasm NA NA Eukaryota PLA2G4C HGNC:9037 phospholipase A2, group IVC (cytosolic, calcium-independent) Q9UP65 Membrane; Lipid-anchor. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12502717,12502717 cytoplasm 12 1 endoplasmic reticulum. golgi apparatus multiple Mammalia Euteleostomi Opisthokonta PLA2G4D HGNC:30038 phospholipase A2, group IVD (cytosolic) Q86XP0 Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Translocates to membrane vesicles in a calcium- dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota PLA2G4E HGNC:24791 phospholipase A2, group IVE Q3MJ16 Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Translocates to lysosomal membranes in a calcium-dependent fashion (By similarity). Cytosol (GO:0005829); Lysosome (GO:0005764) 15866882,15866882 cytoplasm 19 0 cytoplasm. lysosome multiple Tetrapoda Euteleostomi Eukaryota PLA2G4F HGNC:27396 phospholipase A2, group IVF Q68DD2 Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Translocates to lysosomal membranes in a calcium-dependent fashion (By similarity). Cytoplasm (GO:0005737) 15866882 cytoplasm 19 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota PLA2G5 HGNC:9038 phospholipase A2, group V P39877 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 12963740,8300559,12963740,12963740,10531350,10531350 secreted 35 0 cytoplasm. golgi apparatus. nucleus. secreted multiple Eutheria Amniota Eumetazoa PLA2G6 HGNC:9039 phospholipase A2, group VI (cytosolic, calcium-independent) O60733 Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Isoform SH-iPLA2: Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 9079687,10336645,14634037 nucleus 15 2 cytoplasm. endoplasmic reticulum multiple Bilateria Bilateria Cell.Organisms PLA2G7 HGNC:9040 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Q13093 Secreted, extracellular space. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 8675689,10362256,8913710,9412624 secreted 100 0 cytoplasm. nucleus. secreted multiple Opisthokonta Eukaryota Cell.Organisms PLA2R1 HGNC:9042 phospholipase A2 receptor 1, 180kDa Q13018 Cell membrane; Single-pass type I membrane protein (By similarity). Soluble secretory phospholipase A2 receptor: Secreted (By similarity). Isoform 2: Secreted (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7721806,7721806 endoplasmic reticulum membrane 47 1 plasma membrane. secreted multiple Deuterostomia Bilateria Cell.Organisms PLAA HGNC:9043 phospholipase A2-activating protein Q9Y263 Cytoplasm (GO:0005737) cytoplasm 10 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PLAC1 HGNC:9044 placenta-specific 1 Q9HBJ0 Secreted (Probable). secreted 90 0 secreted secreted Eutheria Eutheria Eutheria PLAC4 HGNC:14616 placenta-specific 4 Q8WY50 secreted 64 0 secreted secreted NA NA NA PLAC8 HGNC:19254 placenta-specific 8 Q9NZF1 Extracellular (GO:0005576) 12384430 cytoplasm 34 0 secreted secreted Chordata Eukaryota Eukaryota PLAC8L1 HGNC:31746 PLAC8-like 1 A1L4L8 cytoplasm 28 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa PLAC9 HGNC:19255 placenta-specific 9 Q5JTB6 Secreted (Potential). secreted 59 0 secreted secreted Euarchontoglires Amniota Eutheria PLAG1 HGNC:9045 pleiomorphic adenoma gene 1 Q6DJT9 Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited. Nucleus (GO:0005634) 10646861 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota PLAGL1 HGNC:9046 pleiomorphic adenoma gene-like 1 Q9UM63 Nucleus. Nucleus (GO:0005634) 9671765,11313869,10597250,12473647 nucleus 100 0 nucleus nucleus Amniota Amniota Eukaryota PLAGL2 HGNC:9047 pleiomorphic adenoma gene-like 2 Q9UPG8 Nucleus (Probable). Nucleus (GO:0005634) 11498794 nucleus 40 0 nucleus nucleus Theria Euteleostomi Eukaryota PLAT HGNC:9051 plasminogen activator, tissue P00750 Secreted, extracellular space. Extracellular (GO:0005576) 8533091 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms PLAU HGNC:9052 plasminogen activator, urokinase P00749 Secreted. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10362070,10362070,9824347,9516128 secreted 100 0 cytoplasm. secreted multiple Amniota Euteleostomi Cell.Organisms PLAUR HGNC:9053 plasminogen activator, urokinase receptor Q03405 Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 2: Secreted (Probable). Plasma membrane (GO:0005886) 1316922,18718938 secreted 17 0 secreted secreted Eutheria Eutheria Euteleostomi PLB1 HGNC:30041 phospholipase B1 Q6P1J6 Apical cell membrane; Single-pass type I membrane protein (By similarity). Note=Present in the intestinal brush border membranes (By similarity). Extracellular (GO:0005576) 1215957 plasma membrane 63 1 secreted secreted Bilateria Bilateria Opisthokonta PLBD1 HGNC:26215 phospholipase B domain containing 1 Q6P4A8 Cytoplasmic granule. Secreted. secreted 58 0 secreted secreted Bilateria Eukaryota Cell.Organisms PLBD2 HGNC:27283 phospholipase B domain containing 2 Q8NHP8 Lysosome lumen. Lysosome (GO:0005764) 17105447 secreted 25 0 lysosome lysosome Bilateria Eukaryota Cell.Organisms PLCB1 HGNC:15917 phospholipase C, beta 1 (phosphoinositide-specific) Q9NQ66 Nucleus membrane (By similarity). Cytoplasm (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11118617,10760467,11118617,11118617,10760467 nucleus 47 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Eukaryota PLCB2 HGNC:9055 phospholipase C, beta 2 Q00722 Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634) 11118617,11118617,11118617 nucleus 35 0 cytoplasm. nucleus. secreted multiple Bilateria Opisthokonta Eukaryota PLCB3 HGNC:9056 phospholipase C, beta 3 (phosphatidylinositol-specific) Q01970 Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634) 11118617,11118617,11118617,17081983 nucleus 90 0 cytoplasm. nucleus. secreted multiple Bilateria Opisthokonta Eukaryota PLCB4 HGNC:9059 phospholipase C, beta 4 Q15147 Nucleus (GO:0005634) 17081983 nucleus 25 0 nucleus nucleus Bilateria Opisthokonta Eukaryota PLCD1 HGNC:9060 phospholipase C, delta 1 P51178 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11336645,11336645 cytoplasm 25 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PLCD3 HGNC:9061 phospholipase C, delta 3 Q8N3E9 Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11706040,10336610,9799116,9799116 cytoplasm 22 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PLCD4 HGNC:9062 phospholipase C, delta 4 Q9BRC7 Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Cytoplasm. Endoplasmic reticulum (By similarity). Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Endoplasmic reticulum (GO:0005783) 11706040,15037625,15037625,15037625,15037625,15037625 cytoplasm 25 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Eukaryota PLCE1 HGNC:17175 phospholipase C, epsilon 1 Q9P212 Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11022048,11022048 nucleus 22 0 cytoplasm cytoplasm Amniota Bilateria Eukaryota PLCG1 HGNC:9065 phospholipase C, gamma 1 P19174 Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8905292,11823862,17081983 cytoplasm 20 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota PLCG2 HGNC:9066 phospholipase C, gamma 2 (phosphatidylinositol-specific) P16885 Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 8093016,16923831 cytoplasm 36 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PLCH1 HGNC:29185 phospholipase C, eta 1 Q4KWH8 Cytoplasm. Membrane. cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PLCH2 HGNC:29037 phospholipase C, eta 2 O75038 Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane (By similarity). Plasma membrane (GO:0005886) 15899900 cytoplasm 30 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PLCL1 HGNC:9063 phospholipase C-like 1 Q15111 Cytoplasm (By similarity). cytoplasm 93 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota PLCL2 HGNC:9064 phospholipase C-like 2 Q9UPR0 Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells (By similarity). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10581172,10581172,10581172 cytoplasm 100 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Opisthokonta Eukaryota PLCXD1 HGNC:23148 phosphatidylinositol-specific phospholipase C, X domain containing 1 Q9NUJ7 nucleus 22 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms PLCXD2 HGNC:26462 phosphatidylinositol-specific phospholipase C, X domain containing 2 Q0VAA5 nucleus 15 0 nucleus nucleus NA NA Cell.Organisms PLCXD3 HGNC:31822 phosphatidylinositol-specific phospholipase C, X domain containing 3 Q63HM9 nucleus 21 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms PLCZ1 HGNC:19218 phospholipase C, zeta 1 Q86YW0 Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). Cytoplasm (GO:0005737) cytoplasm 27 0 cytoplasm cytoplasm Theria Amniota Eukaryota PLD1 HGNC:9067 phospholipase D1, phosphatidylcholine-specific Q13393 Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side (By similarity). Late endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Perinuclear region (GO:0048471);Nucleus (GO:0005634) 8530346,9395408,9395408,9395408,8530346,8530346,16923831/17081983 cytoplasm 28 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus. secreted multiple Opisthokonta Eukaryota Cell.Organisms PLD2 HGNC:9068 phospholipase D2 O14939 Membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12519790,9395408,9395408,11687572,12429836,11018470 cytoplasm 25 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Cell.Organisms PLD3 HGNC:17158 phospholipase D family, member 3 Q8IV08 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus (GO:0005794);Endoplasmic reticulum (GO:0005783) 9140189/15794758 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Bilateria Eukaryota Cell.Organisms PLD4 HGNC:23792 phospholipase D family, member 4 Q96BZ4 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 36 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Bilateria Cell.Organisms PLD5 HGNC:26879 phospholipase D family, member 5 Q8N7P1 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 25 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Cell.Organisms PLD6 HGNC:30447 phospholipase D family, member 6 Q8N2A8 Mitochondrion outer membrane; Single-pass membrane protein. mitochondrion membrane 100 0 mitochondrion membrane mitochondrion membrane Euteleostomi Cell.Organisms Cell.Organisms PLEC HGNC:9069 plectin Q15149 Cytoplasm, cytoskeleton. Cell junction, hemidesmosome. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Nucleolus (GO:0005730); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8633055,3027087,14668477,17081983,10446808,17081983,8633055,11441066,3027087,8626512,15561729,15635413,14668477,15598749/17081983,17081983 cytoplasm 92 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria NA PLEK HGNC:9070 pleckstrin P08567 Plasma membrane (GO:0005886) 10860665,9060471 cytoplasm 24 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota PLEK2 HGNC:19238 pleckstrin 2 Q9NYT0 Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886) 10419454 secreted 18 0 cytoplasm cytoplasm Chordata Chordata Eukaryota PLEKHA1 HGNC:14335 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Q9HB21 Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11802782,12101241,14516276,11802782,12101241,11802782,12101241,14516276 cytoplasm 15 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota PLEKHA2 HGNC:14336 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 Q9HB19 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2 (By similarity). cytoplasm 12 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota PLEKHA3 HGNC:14338 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 Q9HB20 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Golgi apparatus (GO:0005794) 15107860 cytoplasm 25 0 golgi apparatus golgi apparatus Euteleostomi Eukaryota Eukaryota PLEKHA4 HGNC:14339 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Q9H4M7 Cytoplasm (Probable). Membrane; Peripheral membrane protein (Probable). Plasma membrane (GO:0005886) cytoplasm 15 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota PLEKHA5 HGNC:30036 pleckstrin homology domain containing, family A member 5 Q9HAU0 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PLEKHA6 HGNC:17053 pleckstrin homology domain containing, family A member 6 Q9Y2H5 cytoplasm 21 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota PLEKHA7 HGNC:27049 pleckstrin homology domain containing, family A member 7 Q6IQ23 Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1. nucleus 30 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota PLEKHA8 HGNC:30037 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Q96JA3 Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes. Golgi apparatus (GO:0005794) 15107860 cytoplasm 24 0 cytoplasm. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota PLEKHB1 HGNC:19079 pleckstrin homology domain containing, family B (evectins) member 1 Q9UF11 Membrane. Cytoplasm (By similarity). Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. Plasma membrane (GO:0005886) 10585447 secreted 14 1 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa PLEKHB2 HGNC:19236 pleckstrin homology domain containing, family B (evectins) member 2 Q96CS7 Recycling endosome membrane; Peripheral membrane protein. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR. Golgi membrane (GO:0000139) 10200314 cytoplasm 28 1 golgi apparatus membrane golgi apparatus membrane Deuterostomia Deuterostomia Holozoa PLEKHD1 HGNC:20148 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 A6NEE1 nucleus 22 0 nucleus nucleus Amniota Bilateria Holozoa PLEKHF1 HGNC:20764 pleckstrin homology domain containing, family F (with FYVE domain) member 1 Q96S99 Nucleus. Cytoplasm, perinuclear region. Lysosome. Note=Translocates to lysosome during apoptosis. nucleus 17 0 cytoplasm. lysosome. nucleus multiple Tetrapoda Tetrapoda Eukaryota PLEKHF2 HGNC:20757 pleckstrin homology domain containing, family F (with FYVE domain) member 2 Q9H8W4 Cytoplasm (GO:0005737) 17081983 nucleus 38 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PLEKHG1 HGNC:20884 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 Q9ULL1 cytoplasm 12 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PLEKHG2 HGNC:29515 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Q9H7P9 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 15 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota PLEKHG3 HGNC:20364 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 A1L390 cytoplasm 13 0 cytoplasm cytoplasm Mammalia Euteleostomi Eukaryota PLEKHG4 HGNC:24501 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Q58EX7 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota PLEKHG4B HGNC:29399 pleckstrin homology domain containing, family G (with RhoGef domain) member 4B Q96PX9 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota PLEKHG5 HGNC:29105 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 O94827 Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions (By similarity). cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PLEKHG6 HGNC:25562 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 Q3KR16 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR. cytoplasm 9 0 cytoplasm cytoplasm Theria Theria Eukaryota PLEKHG7 HGNC:33829 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 Q6ZR37 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota PLEKHH1 HGNC:17733 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 Q9ULM0 cytoplasm 17 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PLEKHH2 HGNC:30506 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 Q8IVE3 Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K. Cytoskeleton (GO:0005856) cytoplasm 19 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PLEKHH3 HGNC:26105 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Q7Z736 Cytoskeleton (GO:0005856); Nucleus (GO:0005634) ,17081983 cytoplasm 13 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota PLEKHJ1 HGNC:18211 pleckstrin homology domain containing, family J member 1 Q9NW61 cytoplasm 17 0 cytoplasm cytoplasm Chordata Bilateria Holozoa PLEKHM1 HGNC:29017 pleckstrin homology domain containing, family M (with RUN domain) member 1 Q9Y4G2 Cytoplasm (Potential). Cytoplasm (GO:0005737) 12820725 cytoplasm 14 0 cytoplasm cytoplasm NA NA Eukaryota PLEKHM2 HGNC:29131 pleckstrin homology domain containing, family M (with RUN domain) member 2 Q8IWE5 Cytoplasm. Cytosol (GO:0005829) 15905402 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa PLEKHM3 HGNC:34006 pleckstrin homology domain containing, family M, member 3 Q6ZWE6 cytoplasm 16 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota PLEKHN1 HGNC:25284 pleckstrin homology domain containing, family N member 1 Q494U1 nucleus 54 0 nucleus nucleus Mammalia Tetrapoda Bilateria PLEKHO1 HGNC:24310 pleckstrin homology domain containing, family O member 1 Q53GL0 Cell membrane. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10799509,10799509 cytoplasm 69 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Chordata PLEKHO2 HGNC:30026 pleckstrin homology domain containing, family O member 2 Q8TD55 cytoplasm 22 0 cytoplasm cytoplasm NA NA Chordata PLEKHS1 HGNC:26285 pleckstrin homology domain containing, family S member 1 Q5SXH7 cytoplasm 29 0 cytoplasm cytoplasm Amniota Amniota Bilateria PLET1 HGNC:30053 placenta expressed transcript 1 Q6UQ28 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 21 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Amniota Mammalia PLG HGNC:9071 plasminogen P00747 Secreted. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface. Extracellular (GO:0005576) 2318848,5475635,16188874 secreted 100 0 secreted secreted Amniota Bilateria Cell.Organisms PLGLB1 HGNC:9072 plasminogen-like B1 Q02325 Secreted. secreted 100 0 secreted secreted Human Human Euteleostomi PLGLB2 HGNC:9073 plasminogen-like B2 Q02325 Secreted. secreted 100 0 secreted secreted Human Human Euteleostomi PLGRKT HGNC:23633 plasminogen receptor, C-terminal lysine transmembrane protein Q9HBL7 Cell membrane; Multi-pass membrane protein. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR (By similarity). Integral to membrane (GO:0016021) plasma membrane 100 2 plasma membrane plasma membrane Deuterostomia Bilateria Metazoa PLIN1 HGNC:9076 perilipin 1 O60240 Lipid droplet (By similarity). Note=Lipid droplet surface-associated (By similarity). Cytoplasm (GO:0005737) 15136565 nucleus 48 0 cytoplasm cytoplasm Tetrapoda Bilateria Bilateria PLIN2 HGNC:248 perilipin 2 Q99541 Membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9003395,1518805,9003395,15136565 nucleus 40 0 cytoplasm. endoplasmic reticulum. secreted multiple Deuterostomia Deuterostomia Opisthokonta PLIN3 HGNC:16893 perilipin 3 O60664 Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Lipid droplet (Potential). Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails. Extracellular (GO:0005576); Endosome (GO:0005768); Cytoplasm (GO:0005737) 10393528,9590177,9590177 nucleus 37 0 cytoplasm. endosome. secreted multiple Euteleostomi Euteleostomi Holozoa PLIN4 HGNC:29393 perilipin 4 Q96Q06 Cell membrane (By similarity). Cytoplasm (By similarity). Lipid droplet (By similarity). Note=Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent (By similarity). Cytoplasm (GO:0005737) 12840023 cytoplasm 85 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms PLIN5 HGNC:33196 perilipin 5 Q00G26 Lipid droplet. Note=Lipid droplet surface- associated. nucleus 45 0 lipid droplet lipid droplet Amniota Amniota Holozoa PLK1 HGNC:9077 polo-like kinase 1 P53350 Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813); Microtubule (GO:0005874); Cytoskeleton (GO:0005856) 7790358,12939256,12364337,14532005,12939256,15561729 cytoplasm 42 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PLK2 HGNC:19699 polo-like kinase 2 Q9NYY3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite (By similarity). Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12651910,12651910 cytoplasm 24 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PLK3 HGNC:2154 polo-like kinase 3 Q9H4B4 Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line- specific expression or post-translational modifications. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Plasma membrane (GO:0005886) 11039900,11971976,11039900 cytoplasm 26 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms PLK4 HGNC:11397 polo-like kinase 4 O00444 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus (By similarity). Cleavage furrow. Note=Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows. Nucleolus (GO:0005730); Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11301255,11301255,11301255,8756623 cytoplasm 28 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms PLK5 HGNC:27001 polo-like kinase 5 Q496M5 Nucleus, nucleolus (By similarity). Cytoplasm. nucleus 22 0 cytoplasm cytoplasm Homininae Homininae NA PLLP HGNC:18553 plasmolipin Q9Y342 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11707781,7929173 endoplasmic reticulum membrane 54 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria PLN HGNC:9080 phospholamban P26678 Mitochondrion membrane; Single-pass membrane protein. Sarcoplasmic reticulum (By similarity). Sarcoplasmic reticulum (GO:0016529) 8862513 secreted 55 1 endoplasmic reticulum. mitochondrion membrane multiple Amniota Amniota Euteleostomi PLOD1 HGNC:9081 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 Q02809 Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Endoplasmic reticulum (GO:0005783) 6229534,798297 endoplasmic reticulum 12 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms PLOD2 HGNC:9082 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 O00469 Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Endoplasmic reticulum (GO:0005783) 10748089 endoplasmic reticulum 16 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms PLOD3 HGNC:9083 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 O60568 Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10934207,10934207 endoplasmic reticulum 12 0 endoplasmic reticulum. golgi apparatus multiple Bilateria Bilateria Cell.Organisms PLP1 HGNC:9086 proteolipid protein 1 P60201 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 3768366,9728768 golgi apparatus membrane 16 4 endoplasmic reticulum. plasma membrane multiple Tetrapoda Tetrapoda Bilateria PLP2 HGNC:9087 proteolipid protein 2 (colonic epithelium-enriched) Q04941 Membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12529377,9124532 plasma membrane 28 4 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi NA PLRG1 HGNC:9089 pleiotropic regulator 1 O43660 Nucleus. Nucleus speckle. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11544257,11101529,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms PLS1 HGNC:9090 plastin 1 Q14651 Cytoplasm. Cytoplasm (GO:0005737) 8428952,2111166 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms PLS3 HGNC:9091 plastin 3 P13797 Cytoplasm. Cytoplasm (GO:0005737) 4053036,2378651 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota NA PLSCR1 HGNC:9092 phospholipid scramblase 1 O15162 Membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Plasma membrane (GO:0005886) 8663431,9712717,11390389,9218461,12605885 mitochondrion membrane 44 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms PLSCR2 HGNC:16494 phospholipid scramblase 2 Q9NRY7 Membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10930526,12509439 mitochondrion membrane 44 1 nucleus. plasma membrane multiple Human Human Cell.Organisms PLSCR3 HGNC:16495 phospholipid scramblase 3 Q9NRY6 Mitochondrion membrane; Single-pass type II membrane protein. Mitochondrion (GO:0005739) 14573790,12649167 mitochondrion membrane 100 0 mitochondrion. mitochondrion membrane multiple Human Theria NA PLSCR4 HGNC:16497 phospholipid scramblase 4 Q9NRQ2 Membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886) 10930526 mitochondrion membrane 28 1 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms PLSCR5 HGNC:19952 phospholipid scramblase family, member 5 A0PG75 mitochondrion membrane 36 0 mitochondrion membrane mitochondrion membrane NA NA Cell.Organisms PLTP HGNC:9093 phospholipid transfer protein P55058 Secreted. Extracellular (GO:0005576) 7654777,9624168 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eukaryota PLVAP HGNC:13635 plasmalemma vesicle associated protein Q9BX97 Cell membrane; Single-pass type II membrane protein (By similarity). Membrane, caveola; Single-pass type II membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region (By similarity). Plasma membrane (GO:0005886) 10366592,12475376 cytoplasm 14 1 plasma membrane plasma membrane Eutheria Mammalia Euteleostomi PLXDC1 HGNC:20945 plexin domain containing 1 Q8IUK5 Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Isoform 2: Secreted (Potential). Isoform 3: Secreted (Potential). Isoform 4: Cytoplasm (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11559528,16574105,16574105 plasma membrane 51 1 cytoplasm. plasma membrane multiple Euarchontoglires Euteleostomi Cell.Organisms PLXDC2 HGNC:21013 plexin domain containing 2 Q6UX71 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 49 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms PLXNA1 HGNC:9099 plexin A1 Q9UIW2 Cell membrane (Probable); Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 10520995 plasma membrane 95 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms PLXNA2 HGNC:9100 plexin A2 O75051 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 8570614 plasma membrane 96 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms PLXNA3 HGNC:9101 plexin A3 P51805 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 8570614 plasma membrane 93 1 plasma membrane plasma membrane Bilateria Bilateria NA PLXNA4 HGNC:9102 plexin A4 Q9HCM2 Cell membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 60 1 plasma membrane plasma membrane NA NA Cell.Organisms PLXNB1 HGNC:9103 plexin B1 O43157 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10520995,10520995 plasma membrane 84 1 plasma membrane. secreted multiple Bilateria Bilateria Cell.Organisms PLXNB2 HGNC:9104 plexin B2 O15031 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10520995 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Holozoa PLXNB3 HGNC:9105 plexin B3 Q9ULL4 Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane. Plasma membrane (GO:0005886) 10520995 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria NA PLXNC1 HGNC:9106 plexin C1 O60486 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9586637 plasma membrane 20 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms PLXND1 HGNC:9107 plexin D1 Q9Y4D7 Cell membrane; Single-pass membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 89 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms PM20D1 HGNC:26518 peptidase M20 domain containing 1 Q6GTS8 Secreted (Potential). vacuole membrane 18 1 vacuole membrane vacuole membrane Deuterostomia Cell.Organisms Cell.Organisms PM20D2 HGNC:21408 peptidase M20 domain containing 2 Q8IYS1 cytoplasm 40 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms PMAIP1 HGNC:9108 phorbol-12-myristate-13-acetate-induced protein 1 Q13794 Mitochondrion. Mitochondrion (GO:0005739) 14500711,15102863,10807576 mitochondrion 100 0 mitochondrion mitochondrion Euarchontoglires Amniota Amniota PMCH HGNC:9109 pro-melanin-concentrating hormone P20382 Secreted. Extracellular (GO:0005576) 11483240,11122347 secreted 100 0 secreted secreted Amniota Amniota Euteleostomi PMEL HGNC:10880 premelanosome protein P40967 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. M-alpha: Secreted. Endosome (GO:0005768); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11266471,11694580,11266471,11694580,9743519 plasma membrane 22 1 cytoplasm. endoplasmic reticulum membrane. endosome. golgi apparatus. melanosome. secreted multiple Euteleostomi Euteleostomi Deuterostomia PMEPA1 HGNC:14107 prostate transmembrane protein, androgen induced 1 Q969W9 Cell membrane; Single-pass membrane protein (Potential). Cytoplasm (GO:0005737) 12670906 nucleus 13 1 cytoplasm cytoplasm Tetrapoda Tetrapoda Bilateria PMF1 HGNC:9112 polyamine-modulated factor 1 Q6P1K2 Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. nucleus 100 0 nucleus nucleus Theria Deuterostomia Opisthokonta PMFBP1 HGNC:17728 polyamine modulated factor 1 binding protein 1 Q8TBY8 Kinetochore (GO:0000776); Nucleus (GO:0005634) 15824131, cytoplasm 22 0 cytoplasm cytoplasm Eutheria Amniota Bilateria PML HGNC:9113 promyelocytic leukemia P29590 Nucleus. Nucleus, nucleoplasm. Cytoplasm. Nucleus, PML body. Nucleus, nucleolus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2, isoform PML-3, isoform PML- 4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML- NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein. Nucleus (GO:0005634); Nuclear matrix (GO:0016363);Cytoplasm (GO:0005737);Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Centrosome (GO:0005813);Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nuclear matrix (GO:0016363) 1311253,7780148/12093737/11704850/1311253,1311253,15749021/12093737/10669754,17000644,15705566,9671498,15017387,11399766,15652821,17081983,10669754,17081983,11158586,7780148 cytoplasm 17 0 cytoplasm. nucleus multiple Amniota Amniota Metazoa PMM1 HGNC:9114 phosphomannomutase 1 Q92871 Cytoplasm. Cytoplasm (GO:0005737) 9376685 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PMM2 HGNC:9115 phosphomannomutase 2 O15305 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11701646,11404002 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PMP2 HGNC:9117 peripheral myelin protein 2 P02689 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 7525873,2458918,2453513,6206203,6206203 cytoplasm 79 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eumetazoa PMP22 HGNC:9118 peripheral myelin protein 22 Q01453 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8786387,1556154 plasma membrane 100 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa PMPCA HGNC:18667 peptidase (mitochondrial processing) alpha Q10713 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 9299349,7836378,10942759,15598749 mitochondrion 82 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms PMPCB HGNC:9119 peptidase (mitochondrial processing) beta O75439 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 9700204,15598749 mitochondrion 87 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PMS1 HGNC:9121 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) P54277 Nucleus (Potential). Nucleus (GO:0005634) 10459502 nucleus 27 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms PMS2 HGNC:9122 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) P54278 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10954713,10954713 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PMVK HGNC:9141 phosphomevalonate kinase Q15126 Peroxisome. Peroxisome (GO:0005777) 10191291 peroxisome 100 0 peroxisome peroxisome Theria Bilateria Cell.Organisms PNCK HGNC:13415 pregnancy up-regulated nonubiquitous CaM kinase Q6P2M8 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 47 0 nucleus nucleus Mammalia Cell.Organisms NA PNISR HGNC:21222 PNN-interacting serine/arginine-rich protein Q8TF01 Nucleus speckle. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria PNKD HGNC:9153 paroxysmal nonkinesigenic dyskinesia Q8N490 Isoform 1: Membrane; Peripheral membrane protein. Isoform 2: Cytoplasm. Nucleus. Isoform 3: Mitochondrion. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 15496428,15496428,15496428,15496428 cytoplasm 28 1 cytoplasm. mitochondrion. nucleus. plasma membrane multiple Euteleostomi Cell.Organisms Cell.Organisms PNKP HGNC:9154 polynucleotide kinase 3'-phosphatase Q96T60 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10446193,15635413 nucleus 100 0 nucleus nucleus Theria Eukaryota Cell.Organisms PNLDC1 HGNC:21185 poly(A)-specific ribonuclease (PARN)-like domain containing 1 Q8NA58 Membrane; Single-pass type IV membrane protein (Potential). nucleus 23 1 nucleus nucleus Amniota Eukaryota Eukaryota PNLIP HGNC:9155 pancreatic lipase P16233 Secreted. Extracellular (GO:0005576); Zymogen granule (GO:0042588) 9631512,16278343 secreted 100 0 secreted secreted Deuterostomia Bilateria Cell.Organisms PNLIPRP1 HGNC:9156 pancreatic lipase-related protein 1 P54315 Secreted. Extracellular (GO:0005576) 1379598 secreted 100 0 secreted secreted Deuterostomia Bilateria NA PNLIPRP2 HGNC:9157 pancreatic lipase-related protein 2 P54317 Secreted. Extracellular (GO:0005576) 1379598 secreted 100 0 secreted secreted Deuterostomia Bilateria NA PNLIPRP3 HGNC:23492 pancreatic lipase-related protein 3 Q17RR3 Secreted (Potential). secreted 38 0 secreted secreted Catarrhini Bilateria Cell.Organisms PNMA1 HGNC:9158 paraneoplastic Ma antigen 1 Q8ND90 Nucleus, nucleolus. Note=In tumor cells, it is cytoplasmic. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10050892,10050892 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Tetrapoda Bilateria PNMA2 HGNC:9159 paraneoplastic Ma antigen 2 Q9UL42 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10362822,10362822,10362822 nucleus 100 0 cytoplasm. nucleus multiple NA NA Deuterostomia PNMA3 HGNC:18742 paraneoplastic Ma antigen 3 Q9UL41 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 11558790 nucleus 38 0 nucleus nucleus Euarchontoglires Deuterostomia Deuterostomia PNMA5 HGNC:18743 paraneoplastic Ma antigen family member 5 Q96PV4 nucleus 35 0 nucleus nucleus Euarchontoglires Euarchontoglires NA PNMA6A HGNC:28248 paraneoplastic Ma antigen family member 6A P0CW24 nucleus 32 0 nucleus nucleus NA NA Euteleostomi PNMA6C HGNC:41914 paraneoplastic Ma antigen family member 6C P0CW26 nucleus 31 0 nucleus nucleus NA NA NA PNMAL1 HGNC:25578 paraneoplastic Ma antigen family-like 1 Q86V59 nucleus 42 1 nucleus nucleus Eutheria Eutheria Euteleostomi PNMAL2 HGNC:29206 paraneoplastic Ma antigen family-like 2 Q9ULN7 nucleus 30 0 nucleus nucleus Euarchontoglires Euarchontoglires Eutheria PNMT HGNC:9160 phenylethanolamine N-methyltransferase P11086 cytoplasm 25 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms PNN HGNC:9162 pinin, desmosome associated protein Q9H307 Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein. Nucleus (GO:0005634);Plasma membrane (GO:0005886); Nucleus (GO:0005634); Nucleolus (GO:0005730) 17081983/10486276,8922384,10486276,9447706,15561729,12893261 nucleus 23 0 nucleus nucleus Bilateria Opisthokonta Eukaryota PNO1 HGNC:32790 partner of NOB1 homolog (S. cerevisiae) Q9NRX1 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PNOC HGNC:9163 prepronociceptin Q13519 Secreted. Extracellular (GO:0005576) 9521323 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Euteleostomi PNP HGNC:7892 purine nucleoside phosphorylase P00491 Cytoplasm, cytoskeleton (By similarity). Cytoplasm. Cytoplasm (GO:0005737) 100152 cytoplasm 81 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms PNPLA1 HGNC:21246 patatin-like phospholipase domain containing 1 Q8N8W4 Cytoplasm. Note=Clearly distributed in the cytoplasm of keratinocytes. cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Eukaryota PNPLA2 HGNC:30802 patatin-like phospholipase domain containing 2 Q96AD5 Lipid droplet. Cell membrane; Single-pass type II membrane protein. Cytoplasm (GO:0005737) 15337759 cytoplasm 32 0 cytoplasm. lipid droplet. plasma membrane multiple Bilateria Bilateria Eukaryota PNPLA3 HGNC:18590 patatin-like phospholipase domain containing 3 Q9NST1 Membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 15364929,11431482,15364929 cytoplasm 25 1 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota PNPLA4 HGNC:24887 patatin-like phospholipase domain containing 4 P41247 cytoplasm 16 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota PNPLA5 HGNC:24888 patatin-like phospholipase domain containing 5 Q7Z6Z6 cytoplasm 24 1 cytoplasm cytoplasm Eutheria Mammalia Eukaryota PNPLA6 HGNC:16268 patatin-like phospholipase domain containing 6 Q8IY17 Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino- terminal transmembrane segment. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Microsome (GO:0005792) 12514188,6836585,15044461 endoplasmic reticulum membrane 34 4 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Opisthokonta Cell.Organisms Cell.Organisms PNPLA7 HGNC:24768 patatin-like phospholipase domain containing 7 Q6ZV29 Membrane; Single-pass membrane protein (Potential). Nucleus membrane; Single-pass membrane protein (By similarity). Mitochondrion membrane; Single-pass membrane protein (By similarity). Lysosome membrane; Single-pass membrane protein (By similarity). Microsome membrane; Single-pass membrane protein (By similarity). Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions (By similarity). endoplasmic reticulum membrane 34 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Cell.Organisms Cell.Organisms PNPLA8 HGNC:28900 patatin-like phospholipase domain containing 8 Q9NP80 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Golgi apparatus membrane; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Plasma membrane (GO:0005886); Peroxisome (GO:0005777) 10833412,10744668,10744668 mitochondrion 30 1 peroxisome. plasma membrane multiple Bilateria Eukaryota Cell.Organisms PNPO HGNC:30260 pyridoxamine 5'-phosphate oxidase Q9NVS9 Cytoplasm (GO:0005737) 9601034 mitochondrion 42 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms PNPT1 HGNC:23166 polyribonucleotide nucleotidyltransferase 1 Q8TCS8 Cytoplasm. Mitochondrion. Mitochondrion intermembrane space; Peripheral membrane protein. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12473748,12798676,15598749,15561729 mitochondrion 28 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Cell.Organisms Cell.Organisms PNRC1 HGNC:17278 proline-rich nuclear receptor coactivator 1 Q12796 Nucleus (Potential). Nucleus (GO:0005634) 15122321 nucleus 74 0 nucleus nucleus Amniota Euteleostomi Amniota PNRC2 HGNC:23158 proline-rich nuclear receptor coactivator 2 Q9NPJ4 Nucleus. Cytoplasm, P-body. nucleus 45 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata POC1A HGNC:24488 POC1 centriolar protein A Q8NBT0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Component of both mother and daughter centrioles. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms POC1B HGNC:30836 POC1 centriolar protein B Q8TC44 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Component of both mother and daughter centrioles. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms POC5 HGNC:26658 POC5 centriolar protein Q8NA72 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota PODN HGNC:23174 podocan Q7Z5L7 Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Cytoplasm (Probable). Isoform 3: Cytoplasm (Probable). Isoform 4: Cytoplasm (Probable). secreted 92 0 cytoplasm. secreted multiple Eutheria Chordata Cell.Organisms PODNL1 HGNC:26275 podocan-like 1 Q6PEZ8 Secreted, extracellular space, extracellular matrix (By similarity). secreted 39 0 secreted secreted Mammalia Eukaryota Cell.Organisms PODXL HGNC:9171 podocalyxin-like O00592 Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus (By similarity). Membrane raft (By similarity). Membrane; Single-pass type I membrane protein (Potential). Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity). Integral to membrane (GO:0016021) 9625756 secreted 11 1 secreted secreted Eutheria Euteleostomi Opisthokonta PODXL2 HGNC:17936 podocalyxin-like 2 Q9NZ53 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) ,17081983 plasma membrane 58 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata POF1B HGNC:13711 premature ovarian failure, 1B Q8WVV4 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata POFUT1 HGNC:14988 protein O-fucosyltransferase 1 Q9H488 Endoplasmic reticulum (By similarity). Golgi membrane (GO:0000139) 11524432 endoplasmic reticulum 89 0 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Holozoa POFUT2 HGNC:14683 protein O-fucosyltransferase 2 Q9Y2G5 Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 15233996,15233996 endoplasmic reticulum 77 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Bilateria Eukaryota Eukaryota POGK HGNC:18800 pogo transposable element with KRAB domain Q9P215 Nucleus (Probable). nucleus 32 0 nucleus nucleus Theria Eukaryota Eukaryota POGLUT1 HGNC:22954 protein O-glucosyltransferase 1 Q8NBL1 Endoplasmic reticulum lumen. Extracellular (GO:0005576) 12975309 endoplasmic reticulum 100 0 endoplasmic reticulum. secreted multiple Deuterostomia Eukaryota Cell.Organisms POGZ HGNC:18801 pogo transposable element with ZNF domain Q7Z3K3 Nucleus. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 nucleus 10 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota POLA1 HGNC:9173 polymerase (DNA directed), alpha 1, catalytic subunit P09884 Nucleus. Nucleus (GO:0005634) 3820307,7085672,8760400,16438930 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLA2 HGNC:30073 polymerase (DNA directed), alpha 2, accessory subunit Q14181 Nucleus. Nucleus (GO:0005634) 8223465 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota POLB HGNC:9174 polymerase (DNA directed), beta P06746 Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage. Nucleus (GO:0005634) 9294209 nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms POLD1 HGNC:9175 polymerase (DNA directed), delta 1, catalytic subunit P28340 Nucleus. Nucleus (GO:0005634) 1722322 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLD2 HGNC:9176 polymerase (DNA directed), delta 2, accessory subunit P49005 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Eukaryota POLD3 HGNC:20932 polymerase (DNA-directed), delta 3, accessory subunit Q15054 Nucleus. Nucleus (GO:0005634) 9099749 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota POLD4 HGNC:14106 polymerase (DNA-directed), delta 4, accessory subunit Q9HCU8 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Eukaryota Eukaryota POLDIP2 HGNC:23781 polymerase (DNA-directed), delta interacting protein 2 Q9Y2S7 Nucleus (Probable). Nucleus (GO:0005634) 15561729 nucleus 19 0 nucleus nucleus Bilateria Cell.Organisms NA POLDIP3 HGNC:23782 polymerase (DNA-directed), delta interacting protein 3 Q9BY77 Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Nucleolus (GO:0005730) 15635413 nucleus 23 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Eukaryota POLE HGNC:9177 polymerase (DNA directed), epsilon, catalytic subunit Q07864 Nucleus. Nucleus (GO:0005634) 10673506 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLE2 HGNC:9178 polymerase (DNA directed), epsilon 2, accessory subunit P56282 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota POLE3 HGNC:13546 polymerase (DNA directed), epsilon 3, accessory subunit Q9NRF9 Nucleus (Potential). Nucleus (GO:0005634) 10880450 nucleus 23 1 nucleus nucleus Eukaryota Eukaryota Eukaryota POLE4 HGNC:18755 polymerase (DNA-directed), epsilon 4, accessory subunit Q9NR33 Nucleus (Potential). Nucleus (GO:0005634) nucleus 24 0 nucleus nucleus Chordata Eukaryota Eukaryota POLG HGNC:9179 polymerase (DNA directed), gamma P54098 Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion (GO:0005739) 10827171,15598749 mitochondrion 100 0 mitochondrion mitochondrion Human Opisthokonta Opisthokonta POLG2 HGNC:9180 polymerase (DNA directed), gamma 2, accessory subunit Q9UHN1 Mitochondrion. Mitochondrion (GO:0005739) 10666468 mitochondrion 100 0 mitochondrion mitochondrion NA NA NA POLH HGNC:9181 polymerase (DNA directed), eta Q9Y253 Nucleus. Note=Accumulates at replication forks after DNA damage. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/12426396,12606586 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms POLI HGNC:9182 polymerase (DNA directed) iota Q9UNA4 Nucleus. Note=Accumulates at replication forks after DNA damage. Nucleus (GO:0005634) 15342632,12606586,12426396 nucleus 100 0 nucleus nucleus Mammalia Eukaryota Cell.Organisms POLK HGNC:9183 polymerase (DNA directed) kappa Q9UBT6 Nucleus. Note=Detected throughout the nucleus and at replication foci. Nucleus (GO:0005634) 12414988 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms POLL HGNC:9184 polymerase (DNA directed), lambda Q9UGP5 Nucleus. Nucleus (GO:0005634) 14561766,10887191 nucleus 100 1 nucleus nucleus Amniota Eukaryota Cell.Organisms POLM HGNC:9185 polymerase (DNA directed), mu Q9NP87 Nucleus (By similarity). Nucleus (GO:0005634) 14581466 nucleus 31 0 nucleus nucleus Mammalia Opisthokonta Cell.Organisms POLN HGNC:18870 polymerase (DNA directed) nu Q7Z5Q5 Nucleus. Nucleus (GO:0005634) 12794064 nucleus 100 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms POLQ HGNC:9186 polymerase (DNA directed), theta O75417 Nucleus (GO:0005634) 12051913,14576298 nucleus 21 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms POLR1A HGNC:17264 polymerase (RNA) I polypeptide A, 194kDa O95602 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730) 10567578,11790298 nucleus 29 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLR1B HGNC:20454 polymerase (RNA) I polypeptide B, 128kDa Q9H9Y6 Nucleus, nucleolus. Nucleus (GO:0005634) none,19059367 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLR1C HGNC:20194 polymerase (RNA) I polypeptide C, 30kDa O15160 Nucleus (By similarity). Nucleolus (GO:0005730) 11971179,15635413,11790298 nucleus 33 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLR1D HGNC:20422 polymerase (RNA) I polypeptide D, 16kDa Q9Y2S0 Nucleus (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,12446911 nucleus 32 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLR1E HGNC:17631 polymerase (RNA) I polypeptide E, 53kDa Q9GZS1 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 9254723,8641287,14627545,14613906,14585813,9254723 nucleus 100 3 nucleus nucleus Euteleostomi Eukaryota Eukaryota POLR2A HGNC:9187 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa P24928 Nucleus. Nucleus (GO:0005634) 10773068 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR2B HGNC:9188 polymerase (RNA) II (DNA directed) polypeptide B, 140kDa P30876 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR2C HGNC:9189 polymerase (RNA) II (DNA directed) polypeptide C, 33kDa P19387 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms POLR2D HGNC:9191 polymerase (RNA) II (DNA directed) polypeptide D O15514 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 9528765,9528765,9528765 nucleus 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Opisthokonta Eukaryota Eukaryota POLR2E HGNC:9192 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa P19388 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298,15635413 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR2F HGNC:9193 polymerase (RNA) II (DNA directed) polypeptide F P61218 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10623476,10623476 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR2G HGNC:9194 polymerase (RNA) II (DNA directed) polypeptide G P62487 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLR2H HGNC:9195 polymerase (RNA) II (DNA directed) polypeptide H P52434 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,11790298,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota POLR2I HGNC:9196 polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa P36954 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms POLR2J HGNC:9197 polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa P52435 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms POLR2J2 HGNC:23208 polymerase (RNA) II (DNA directed) polypeptide J2 Q9GZM3 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 96 0 nucleus nucleus NA NA NA POLR2J3 HGNC:33853 polymerase (RNA) II (DNA directed) polypeptide J3 Q9H1A7 Nucleus (By similarity). nucleus 95 0 nucleus nucleus NA NA Cell.Organisms POLR2K HGNC:9198 polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa P53803 Nucleus (By similarity). Nucleus (GO:0005634) 12213660 nucleus 40 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota POLR2L HGNC:9199 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa P62875 Nucleus. Nucleus (GO:0005634) 8786124 nucleus 100 0 nucleus nucleus Euarchontoglires Cell.Organisms Cell.Organisms POLR2M HGNC:14862 polymerase (RNA) II (DNA directed) polypeptide M P0CAP2 Isoform 1: Nucleus (Probable). nucleus 76 0 nucleus nucleus NA NA Bilateria POLR3A HGNC:30074 polymerase (RNA) III (DNA directed) polypeptide A, 155kDa O14802 Nucleus. nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR3B HGNC:30348 polymerase (RNA) III (DNA directed) polypeptide B Q9NW08 Nucleus (By similarity). Nucleus (GO:0005634) 12391170 nucleus 55 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR3C HGNC:30076 polymerase (RNA) III (DNA directed) polypeptide C (62kD) Q9BUI4 Nucleus (By similarity). Nucleus (GO:0005634) 9171375 nucleus 7 0 nucleus nucleus Bilateria Eukaryota NA POLR3D HGNC:1080 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa P05423 Nucleus. Nucleus (GO:0005634) 7799973 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota POLR3E HGNC:30347 polymerase (RNA) III (DNA directed) polypeptide E (80kD) Q9NVU0 Nucleus. Nucleus (GO:0005634) 12391170 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota POLR3F HGNC:15763 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa Q9H1D9 Nucleus (By similarity). Nucleus (GO:0005634) 10623476 nucleus 14 0 nucleus nucleus Eukaryota Eukaryota Eukaryota POLR3G HGNC:30075 polymerase (RNA) III (DNA directed) polypeptide G (32kD) O15318 Nucleus (By similarity). nucleus 91 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa POLR3GL HGNC:28466 polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like Q9BT43 nucleus 92 0 nucleus nucleus Theria Deuterostomia Eumetazoa POLR3H HGNC:30349 polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) Q9Y535 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms POLR3K HGNC:14121 polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa Q9Y2Y1 Nucleus (By similarity). Nucleus (GO:0005634) 10079944 nucleus 49 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms POLRMT HGNC:9200 polymerase (RNA) mitochondrial (DNA directed) O00411 Mitochondrion. Mitochondrion (GO:0005739) 12068295,9097968 mitochondrion 100 0 mitochondrion mitochondrion Theria Eukaryota Cell.Organisms POM121 HGNC:19702 POM121 transmembrane nucleoporin Q96HA1 Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase (By similarity). Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 15304359,17081983,11448991,17081983 nucleus 24 1 cytoplasm. endoplasmic reticulum. nucleus. nucleus membrane multiple Euteleostomi Euteleostomi NA POM121C HGNC:34005 POM121 transmembrane nucleoporin C A8CG34 Nucleus, nuclear pore complex. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase (By similarity). nucleus 24 1 nucleus. nucleus membrane multiple Euteleostomi Euteleostomi Chordata POM121L12 HGNC:25369 POM121 transmembrane nucleoporin-like 12 Q8N7R1 nucleus 71 0 nucleus nucleus NA NA Euteleostomi POM121L2 HGNC:13973 POM121 transmembrane nucleoporin-like 2 Q96KW2 nucleus 12 0 nucleus nucleus Euarchontoglires Eutheria Chordata POMC HGNC:9201 proopiomelanocortin P01189 Secreted. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 1656407,1656407,12887283 secreted 100 0 endoplasmic reticulum. nucleus. secreted multiple Euteleostomi Euteleostomi Craniata POMGNT1 HGNC:19139 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Q8WZA1 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 11709191 golgi apparatus membrane 25 1 endoplasmic reticulum endoplasmic reticulum Deuterostomia Deuterostomia Eukaryota POMGNT2 HGNC:25902 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) Q8NAT1 Secreted (Potential). endoplasmic reticulum membrane 100 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Eukaryota POMK HGNC:26267 protein-O-mannose kinase Q9H5K3 Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable). plasma membrane 23 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eukaryota POMP HGNC:20330 proteasome maturation protein Q9Y244 Cytoplasm, cytosol. Nucleus. Microsome membrane. cytoplasm 17 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota POMT1 HGNC:9202 protein-O-mannosyltransferase 1 Q9Y6A1 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12757935 endoplasmic reticulum membrane 100 13 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Opisthokonta Cell.Organisms POMT2 HGNC:19743 protein-O-mannosyltransferase 2 Q9UKY4 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12460945 endoplasmic reticulum membrane 100 11 endoplasmic reticulum. endoplasmic reticulum membrane multiple Opisthokonta Opisthokonta Cell.Organisms POMZP3 HGNC:9203 POM121 and ZP3 fusion Q6PJE2 nucleus 25 0 nucleus nucleus Human Human Opisthokonta PON1 HGNC:9204 paraoxonase 1 P27169 Secreted, extracellular space. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11726658,16188874 secreted 100 0 secreted secreted Euteleostomi Opisthokonta Cell.Organisms PON2 HGNC:9205 paraoxonase 2 Q15165 Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886) 11579088 secreted 58 0 secreted secreted Euteleostomi Opisthokonta Cell.Organisms PON3 HGNC:9206 paraoxonase 3 Q15166 Secreted, extracellular space (By similarity). Extracellular (GO:0005576) 11304470 secreted 51 0 secreted secreted Theria Cell.Organisms Cell.Organisms POP1 HGNC:30129 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) Q99575 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Ribosome (GO:0005840); Cytoplasm (GO:0005737) 8918471,17081983,11694598,9725903,15635413,11790298,15561729,17081983 nucleus 100 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota POP4 HGNC:30081 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) O95707 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 10352175,15635413,10352175 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota POP5 HGNC:17689 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) Q969H6 Nucleus, nucleolus. Cytoplasm (GO:0005737);Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/11413139,11413139,11413139 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota POP7 HGNC:19949 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) O75817 Nucleus, nucleolus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) 9630247,15635413 nucleus 41 0 nucleus nucleus Mammalia Eukaryota Eukaryota POPDC2 HGNC:17648 popeye domain containing 2 Q9HBU9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 10882522 secreted 12 3 n/a n/a Euteleostomi Euteleostomi Bilateria POPDC3 HGNC:17649 popeye domain containing 3 Q9HBV1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 10882522 secreted 20 3 n/a n/a Chordata Chordata Bilateria POR HGNC:9208 P450 (cytochrome) oxidoreductase P16435 Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Anchored to the ER membrane by its N- terminal hydrophobic region. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11181502,12725870,11971899,15561729 endoplasmic reticulum membrane 26 2 endoplasmic reticulum. mitochondrion. plasma membrane multiple Eukaryota Cell.Organisms NA PORCN HGNC:17652 porcupine homolog (Drosophila) Q9H237 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789); Integral to membrane (GO:0016021) 12034504,12034504 endoplasmic reticulum membrane 96 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria NA POSTN HGNC:16953 periostin, osteoblast specific factor Q15063 Golgi apparatus (By similarity). Secreted, extracellular space, extracellular matrix. Note=Co-localizes with BMP1 in the Golgi (By similarity). secreted 35 0 secreted secreted Euteleostomi Cell.Organisms Cell.Organisms POT1 HGNC:17284 protection of telomeres 1 Q9NUX5 Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA. Nucleus (GO:0005634) 12391173,17237767 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota POTEA HGNC:33893 POTE ankyrin domain family, member A Q6S8J7 cytoplasm 17 0 cytoplasm cytoplasm Homininae Homininae NA POTEB HGNC:33734 POTE ankyrin domain family, member B Q6S5H4 Plasma membrane (GO:0005886) 15276201 cytoplasm 17 1 plasma membrane plasma membrane NA NA Cell.Organisms POTEB2 HGNC:48327 POTE ankyrin domain family, member B2 H3BUK9 mitochondrion 17 2 mitochondrion mitochondrion NA NA Cell.Organisms POTEC HGNC:33894 POTE ankyrin domain family, member C B2RU33 mitochondrion 16 1 mitochondrion mitochondrion Catarrhini Catarrhini Cell.Organisms POTED HGNC:23822 POTE ankyrin domain family, member D Q86YR6 Cell membrane; Peripheral membrane protein. mitochondrion 18 1 mitochondrion mitochondrion Catarrhini Catarrhini Cell.Organisms POTEE HGNC:33895 POTE ankyrin domain family, member E Q6S8J3 Plasma membrane (GO:0005886) 15276201 cytoplasm 90 1 plasma membrane plasma membrane NA NA Cell.Organisms POTEF HGNC:33905 POTE ankyrin domain family, member F A5A3E0 Cytoplasm, cell cortex. Note=Colocalizes with actin filaments. cytoplasm 89 2 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms POTEG HGNC:33896 POTE ankyrin domain family, member G Q6S5H5 Plasma membrane (GO:0005886) 15276201 cytoplasm 15 1 plasma membrane plasma membrane NA NA Cell.Organisms POTEH HGNC:133 POTE ankyrin domain family, member H Q6S545 mitochondrion 15 1 mitochondrion mitochondrion Catarrhini Catarrhini Cell.Organisms POTEI HGNC:37093 POTE ankyrin domain family, member I P0CG38 cytoplasm 89 2 cytoplasm cytoplasm Catarrhini Catarrhini Cell.Organisms POTEJ HGNC:37094 POTE ankyrin domain family, member J P0CG39 cytoplasm 88 2 cytoplasm cytoplasm NA NA Cell.Organisms POTEM HGNC:37096 POTE ankyrin domain family, member M A6NI47 cytoplasm 16 1 cytoplasm cytoplasm Human Human Cell.Organisms POU1F1 HGNC:9210 POU class 1 homeobox 1 P28069 Nucleus. Nucleus (GO:0005634) 10549299 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota POU2AF1 HGNC:9211 POU class 2 associating factor 1 Q16633 Nucleus. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14552839,14552839,16713566,11483518,16713566 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Euteleostomi POU2F1 HGNC:9212 POU class 2 homeobox 1 P14859 Nucleus. Nucleus (GO:0005634) 12598320,12144930 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta POU2F2 HGNC:9213 POU class 2 homeobox 2 P09086 Cytoplasm (By similarity). Nucleus. Nucleus (GO:0005634) 12144930 nucleus 96 0 nucleus nucleus Eutheria Euteleostomi Metazoa POU2F3 HGNC:19864 POU class 2 homeobox 3 Q9UKI9 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Deuterostomia Opisthokonta POU3F1 HGNC:9214 POU class 3 homeobox 1 Q03052 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8663425,12557005,8663425,12557005 nucleus 100 0 cytoplasm. nucleus multiple Theria Theria Metazoa POU3F2 HGNC:9215 POU class 3 homeobox 2 P20265 Nucleus. Nucleus (GO:0005634) 12782656 nucleus 100 0 nucleus nucleus Theria Euteleostomi Opisthokonta POU3F3 HGNC:9216 POU class 3 homeobox 3 P20264 Nucleus. Nucleus (GO:0005634) 9632656 nucleus 100 0 nucleus nucleus Theria Euteleostomi Opisthokonta POU3F4 HGNC:9217 POU class 3 homeobox 4 P49335 Nucleus. Nucleus (GO:0005634) 9667433 nucleus 100 0 nucleus nucleus Mammalia Bilateria Opisthokonta POU4F1 HGNC:9218 POU class 4 homeobox 1 Q01851 Nucleus. Nucleus (GO:0005634) 12810599 nucleus 100 0 nucleus nucleus Bilateria Bilateria Holozoa POU4F2 HGNC:9219 POU class 4 homeobox 2 Q12837 Nucleus speckle. Nucleus (GO:0005634) 12724837 nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Opisthokonta POU4F3 HGNC:9220 POU class 4 homeobox 3 Q15319 Nucleus. Nucleus (GO:0005634) 9506947 nucleus 100 0 nucleus nucleus Bilateria Bilateria Holozoa POU5F1 HGNC:9221 POU class 5 homeobox 1 Q01860 Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15105401,15105401 nucleus 95 0 cytoplasm. nucleus multiple Mammalia Mammalia NA POU5F1B HGNC:9223 POU class 5 homeobox 1B Q06416 Nucleus. nucleus 100 0 nucleus nucleus Mammalia Mammalia Metazoa POU5F2 HGNC:26367 POU domain class 5, transcription factor 2 Q8N7G0 Nucleus (By similarity). nucleus 61 0 nucleus nucleus NA NA NA POU6F1 HGNC:9224 POU class 6 homeobox 1 Q14863 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota POU6F2 HGNC:21694 POU class 6 homeobox 2 P78424 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Euteleostomi Bilateria Eukaryota PP2D1 HGNC:28406 protein phosphatase 2C-like domain containing 1 A8MPX8 mitochondrion 23 0 mitochondrion mitochondrion Tetrapoda Tetrapoda Eukaryota PPA1 HGNC:9226 pyrophosphatase (inorganic) 1 Q15181 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10733883,6118133,6120771,6118133 cytoplasm 94 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms PPA2 HGNC:28883 pyrophosphatase (inorganic) 2 Q9H2U2 Mitochondrion (Potential). Cytoplasm (GO:0005737);Mitochondrion (GO:0005739) 17081983/none,15598749 cytoplasm 50 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PPAN HGNC:9227 peter pan homolog (Drosophila) Q9NQ55 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) 11790298,15561729,17081983 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PPAP2A HGNC:9228 phosphatidic acid phosphatase type 2A O14494 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9705349 plasma membrane 100 6 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms PPAP2B HGNC:9229 phosphatidic acid phosphatase type 2B O14495 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10564277,9705349,10739957 endoplasmic reticulum membrane 93 6 golgi apparatus membrane. plasma membrane multiple Bilateria Bilateria Cell.Organisms PPAP2C HGNC:9230 phosphatidic acid phosphatase type 2C O43688 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Integral to membrane (GO:0016021) 9705349,9705349 plasma membrane 49 6 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota PPAPDC1A HGNC:23531 phosphatidic acid phosphatase type 2 domain containing 1A Q5VZY2 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 21 6 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota PPAPDC1B HGNC:25026 phosphatidic acid phosphatase type 2 domain containing 1B Q8NEB5 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 25 6 vacuole membrane vacuole membrane Eukaryota Eukaryota Cell.Organisms PPAPDC2 HGNC:23682 phosphatidic acid phosphatase type 2 domain containing 2 Q8IY26 Membrane; Multi-pass membrane protein (Potential). plasma membrane 29 5 plasma membrane plasma membrane Theria Eukaryota Cell.Organisms PPAPDC3 HGNC:28174 phosphatidic acid phosphatase type 2 domain containing 3 Q8NBV4 Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 16 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Holozoa PPARA HGNC:9232 peroxisome proliferator-activated receptor alpha Q07869 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11923467,11923467,9748221 nucleus 100 0 cytoplasm. nucleus multiple Amniota Bilateria Metazoa PPARD HGNC:9235 peroxisome proliferator-activated receptor delta Q03181 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 1333051/11551955 nucleus 100 0 nucleus nucleus Chordata Chordata Metazoa PPARG HGNC:9236 peroxisome proliferator-activated receptor gamma P37231 Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12324573,9168928,12324573 nucleus 70 0 cytoplasm. nucleus multiple Theria Bilateria Metazoa PPARGC1A HGNC:9237 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Q9UBK2 Nucleus. Nucleus, PML body (By similarity). Nucleus (GO:0005634); Nucleoplasm (GO:0005654) 10713165,,10983978, nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa PPARGC1B HGNC:30022 peroxisome proliferator-activated receptor gamma, coactivator 1 beta Q86YN6 Nucleus. Nucleus (GO:0005634) 11854298 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eumetazoa PPAT HGNC:9238 phosphoribosyl pyrophosphate amidotransferase Q06203 Nucleus (GO:0005634) 9108165 mitochondrion 30 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PPBP HGNC:9240 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) P02775 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 1387511,2966071,8950790,1837963,1826003,426909,11167759,6183294,12297130,2713489,1826003,426909 secreted 100 0 cytoplasm. secreted multiple Eutheria Eutheria Craniata PPCDC HGNC:28107 phosphopantothenoylcysteine decarboxylase Q96CD2 cytoplasm 36 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PPCS HGNC:25686 phosphopantothenoylcysteine synthetase Q9HAB8 cytoplasm 56 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PPDPF HGNC:16142 pancreatic progenitor cell differentiation and proliferation factor Q9H3Y8 secreted 54 0 secreted secreted Euteleostomi Euteleostomi Craniata PPEF1 HGNC:9243 protein phosphatase, EF-hand calcium binding domain 1 O14829 nucleus 18 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms PPEF2 HGNC:9244 protein phosphatase, EF-hand calcium binding domain 2 O14830 Cytoplasm (Probable). Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Localized to photoreceptors, PPEF-2(L) is at least 2 fold more abundant in rod inner segments than in the outer segments. cytoplasm 24 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PPFIA1 HGNC:9245 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Q13136 Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886);Cytoplasm (GO:0005737); Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7796809,7796809/7796809,7796809,9624153/7796809,7796809,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota PPFIA2 HGNC:9246 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 O75334 Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9624153,9624153 cytoplasm 64 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PPFIA3 HGNC:9247 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 O75145 Cytoplasm (By similarity). Cell surface (By similarity). Note=Colocalizes with PTPRF at the cell surface (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9624153,9624153 cytoplasm 56 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa PPFIA4 HGNC:9248 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 O75335 Cytoplasm (By similarity). Cell surface (By similarity). Note=Colocalizes with PTPRF at the cell surface (By similarity). cytoplasm 62 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PPFIBP1 HGNC:9249 PTPRF interacting protein, binding protein 1 (liprin beta 1) Q86W92 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11836260,9624153,11836260,17081983,17081983 cytoplasm 19 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa PPFIBP2 HGNC:9250 PTPRF interacting protein, binding protein 2 (liprin beta 2) Q8ND30 Plasma membrane (GO:0005886) 9624153 cytoplasm 20 0 cytoplasm cytoplasm Bilateria Bilateria Opisthokonta PPHLN1 HGNC:19369 periphilin 1 Q8NEY8 Nucleus. Cytoplasm. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 17081983,17081983/12853457,12853457,12853457 nucleus 75 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria PPIA HGNC:9253 peptidylprolyl isomerase A (cyclophilin A) P62937 Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 7829860,11790298,15598749 mitochondrion 72 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Cell.Organisms Cell.Organisms PPIAL4A HGNC:24369 peptidylprolyl isomerase A (cyclophilin A)-like 4A Q9Y536 Cytoplasm (By similarity). cytoplasm 60 0 cytoplasm cytoplasm NA NA Cell.Organisms PPIAL4B HGNC:33994 peptidylprolyl isomerase A (cyclophilin A)-like 4B Q9Y536 Cytoplasm (By similarity). cytoplasm 60 0 cytoplasm cytoplasm NA NA Cell.Organisms PPIAL4C HGNC:33995 peptidylprolyl isomerase A (cyclophilin A)-like 4C Q9Y536 Cytoplasm (By similarity). cytoplasm 60 0 cytoplasm cytoplasm Human Human Cell.Organisms PPIAL4D HGNC:33998 peptidylprolyl isomerase A (cyclophilin A)-like 4D F5H284 Cytoplasm (By similarity). cytoplasm 59 0 cytoplasm cytoplasm NA NA NA PPIAL4G HGNC:33996 peptidylprolyl isomerase A (cyclophilin A)-like 4G A2BFH1 Cytoplasm (By similarity). cytoplasm 60 0 cytoplasm cytoplasm NA NA Cell.Organisms PPIB HGNC:9255 peptidylprolyl isomerase B (cyclophilin B) P23284 Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 7829860,10935542,7829860,10935542,7909608,10935542,7909608,15635413,15598749,15561729 cytoplasm 62 0 cytoplasm. endoplasmic reticulum. golgi apparatus. melanosome. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Cell.Organisms PPIC HGNC:9256 peptidylprolyl isomerase C (cyclophilin C) P45877 Cytoplasm. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 7909608,7909608 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. secreted multiple Euteleostomi Eukaryota Cell.Organisms PPID HGNC:9257 peptidylprolyl isomerase D Q08752 Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11525244,11525244,11525244 mitochondrion 59 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPIE HGNC:9258 peptidylprolyl isomerase E (cyclophilin E) Q9UNP9 Nucleus. Nucleus (GO:0005634) 8977107,11313484 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms PPIF HGNC:9259 peptidylprolyl isomerase F P30405 Mitochondrion matrix. Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 10647893,15598749,11790298,15635413 mitochondrion 100 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PPIG HGNC:14650 peptidylprolyl isomerase G (cyclophilin G) Q13427 Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/9153302,15016823,17081983,15016823,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms PPIH HGNC:14651 peptidylprolyl isomerase H (cyclophilin H) O43447 Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9570313,9570313,15635413 cytoplasm 52 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPIL1 HGNC:9260 peptidylprolyl isomerase (cyclophilin)-like 1 Q9Y3C6 Cytoplasm (GO:0005737) 10072585 nucleus 42 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PPIL2 HGNC:9261 peptidylprolyl isomerase (cyclophilin)-like 2 Q13356 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8660300,15946952,15946952,8524402,15946952 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms PPIL3 HGNC:9262 peptidylprolyl isomerase (cyclophilin)-like 3 Q9H2H8 Cytoplasm (GO:0005737) 11435694 nucleus 42 0 cytoplasm cytoplasm NA NA Cell.Organisms PPIL4 HGNC:15702 peptidylprolyl isomerase (cyclophilin)-like 4 Q8WUA2 Nucleus (Probable). Nucleus (GO:0005634) 11978968 nucleus 36 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms PPIL6 HGNC:21557 peptidylprolyl isomerase (cyclophilin)-like 6 Q8IXY8 nucleus 36 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms PPIP5K1 HGNC:29023 diphosphoinositol pentakisphosphate kinase 1 Q6PFW1 Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. cytoplasm 66 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PPIP5K2 HGNC:29035 diphosphoinositol pentakisphosphate kinase 2 O43314 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota NA PPL HGNC:9273 periplakin O60437 Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane (By similarity). Nucleus (By similarity). Mitochondrion (By similarity). Note=Associated with desmosomes and intermediate filaments. Cell surface (GO:0009986); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12810704,11062259,12810704,11062259,10379702 cytoplasm 4 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa PPM1A HGNC:9275 protein phosphatase, Mg2+/Mn2+ dependent, 1A P35813 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11479720,9003755,11479720,9003755,16751101 nucleus 23 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPM1B HGNC:9276 protein phosphatase, Mg2+/Mn2+ dependent, 1B O75688 Cytoplasm (GO:0005737) 11563908 nucleus 20 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PPM1D HGNC:9277 protein phosphatase, Mg2+/Mn2+ dependent, 1D O15297 Nucleus (GO:0005634) 9177166 mitochondrion 21 0 nucleus nucleus Bilateria Eukaryota Eukaryota PPM1E HGNC:19322 protein phosphatase, Mg2+/Mn2+ dependent, 1E Q8WY54 Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus. endoplasmic reticulum 27 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms PPM1F HGNC:19388 protein phosphatase, Mg2+/Mn2+ dependent, 1F P49593 Cytoplasm (GO:0005737) 11559703 mitochondrion 23 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms PPM1G HGNC:9278 protein phosphatase, Mg2+/Mn2+ dependent, 1G O15355 Cytoplasm (Potential). Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654) 17215244,9887102 nucleus 92 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPM1H HGNC:18583 protein phosphatase, Mg2+/Mn2+ dependent, 1H Q9ULR3 nucleus 39 0 nucleus nucleus Bilateria Bilateria Eukaryota PPM1J HGNC:20785 protein phosphatase, Mg2+/Mn2+ dependent, 1J Q5JR12 nucleus 36 0 nucleus nucleus Bilateria Bilateria Eukaryota PPM1K HGNC:25415 protein phosphatase, Mg2+/Mn2+ dependent, 1K Q8N3J5 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Deuterostomia Cell.Organisms PPM1L HGNC:16381 protein phosphatase, Mg2+/Mn2+ dependent, 1L Q5SGD2 Membrane; Single-pass type I membrane protein (Potential). nucleus 23 1 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms PPM1M HGNC:26506 protein phosphatase, Mg2+/Mn2+ dependent, 1M Q96MI6 Nucleus (By similarity). Nucleus (GO:0005634) 14654243 nucleus 89 0 nucleus nucleus Theria Amniota Eukaryota PPM1N HGNC:26845 protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) Q8N819 nucleus 23 0 nucleus nucleus NA NA Cell.Organisms PPME1 HGNC:30178 protein phosphatase methylesterase 1 Q9Y570 mitochondrion 78 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms PPOX HGNC:9280 protoporphyrinogen oxidase P50336 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side (By similarity). Mitochondrion (GO:0005739) 12357337 secreted 35 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms PPP1CA HGNC:9281 protein phosphatase 1, catalytic subunit, alpha isozyme P62136 Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Cytoskeleton (GO:0005856); Nucleolus (GO:0005730); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 9282913,15635413,15561729,15598749 cytoplasm 92 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP1CB HGNC:9282 protein phosphatase 1, catalytic subunit, beta isozyme P62140 Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Nucleolus (GO:0005730); Microtubule (GO:0005874) 11790298,15561729 cytoplasm 86 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP1CC HGNC:9283 protein phosphatase 1, catalytic subunit, gamma isozyme P36873 Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microtubule (GO:0005874) 9606212,9606212,9606212,11790298,15635413,15561729 cytoplasm 92 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP1R10 HGNC:9284 protein phosphatase 1, regulatory subunit 10 Q96QC0 Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). Nucleus (GO:0005634) 12574161,17000644 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia NA PPP1R11 HGNC:9285 protein phosphatase 1, regulatory (inhibitor) subunit 11 O60927 Cytoplasm (GO:0005737) 17081983 nucleus 91 0 cytoplasm cytoplasm Bilateria Eukaryota NA PPP1R12A HGNC:7618 protein phosphatase 1, regulatory subunit 12A O14974 Cytoplasm. Note=Along actomyosin filaments and stress fibers. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9200713,9200713 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms PPP1R12B HGNC:7619 protein phosphatase 1, regulatory subunit 12B O60237 Cytoplasm. Note=Along actomyosin filaments and stress fibers. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms PPP1R12C HGNC:14947 protein phosphatase 1, regulatory subunit 12C Q9BZL4 Cytoplasm. Note=Along actomyosin filaments and stress fibers. Cytoplasm (GO:0005737) 11399775 cytoplasm 100 0 cytoplasm cytoplasm Eutheria Bilateria Cell.Organisms PPP1R13B HGNC:14950 protein phosphatase 1, regulatory subunit 13B Q96KQ4 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear. Cytoplasm (GO:0005737) nucleus 26 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms PPP1R13L HGNC:18838 protein phosphatase 1, regulatory subunit 13 like Q8WUF5 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear. Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983/12524540,10336463,12134007 cytoplasm 24 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms PPP1R14A HGNC:14871 protein phosphatase 1, regulatory (inhibitor) subunit 14A Q96A00 Cytoplasm (By similarity). cytoplasm 89 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa PPP1R14B HGNC:9057 protein phosphatase 1, regulatory (inhibitor) subunit 14B Q96C90 Cytoplasm (Probable). Cytoplasm (GO:0005737) 15083373 cytoplasm 33 0 cytoplasm cytoplasm Eutheria Bilateria Metazoa PPP1R14C HGNC:14952 protein phosphatase 1, regulatory (inhibitor) subunit 14C Q8TAE6 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 11812771,11812771 cytoplasm 39 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa PPP1R14D HGNC:14953 protein phosphatase 1, regulatory (inhibitor) subunit 14D Q9NXH3 Cytoplasm (Probable). cytoplasm 22 0 cytoplasm cytoplasm Theria Euteleostomi Metazoa PPP1R15A HGNC:14375 protein phosphatase 1, regulatory subunit 15A O75807 Endoplasmic reticulum. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 9153226,12556489 endoplasmic reticulum 100 0 endoplasmic reticulum. nucleus multiple Eutheria Eutheria Bilateria PPP1R15B HGNC:14951 protein phosphatase 1, regulatory subunit 15B Q5SWA1 endoplasmic reticulum 27 0 endoplasmic reticulum endoplasmic reticulum Human Euarchontoglires Bilateria PPP1R16A HGNC:14941 protein phosphatase 1, regulatory subunit 16A Q96I34 Cell membrane; Lipid-anchor (By similarity). cytoplasm 21 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms PPP1R16B HGNC:15850 protein phosphatase 1, regulatory subunit 16B Q96T49 Cell membrane. Cell membrane; Lipid-anchor (Potential). Nucleus. Note=Co-localizes with RPSA/LAMR1 in the cell membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12055102,12055102 cytoplasm 20 0 nucleus nucleus Bilateria Bilateria Cell.Organisms PPP1R17 HGNC:16973 protein phosphatase 1, regulatory subunit 17 O96001 Extracellular (GO:0005576) nucleus 64 0 nucleus nucleus Tetrapoda Tetrapoda Tetrapoda PPP1R18 HGNC:29413 protein phosphatase 1, regulatory subunit 18 Q6NYC8 Cytoplasm, cytoskeleton. Cell junction (GO:0030054); Actin cytoskeleton (GO:0015629) 17374523,17374523 cytoplasm 100 0 cytoplasm cytoplasm Theria Theria NA PPP1R1A HGNC:9286 protein phosphatase 1, regulatory (inhibitor) subunit 1A Q13522 cytoplasm 21 0 cytoplasm cytoplasm Euarchontoglires Euteleostomi Euteleostomi PPP1R1B HGNC:9287 protein phosphatase 1, regulatory (inhibitor) subunit 1B Q9UD71 Cytoplasm. Dendrite (GO:0030425); Axon (GO:0030424); Synapse (GO:0045202); Perinuclear region (GO:0048471) 2191086,2191086,2191086,2191086 cytoplasm 100 0 cytoplasm cytoplasm Theria Euteleostomi Euteleostomi PPP1R1C HGNC:14940 protein phosphatase 1, regulatory (inhibitor) subunit 1C Q8WVI7 Cytoplasm (By similarity). cytoplasm 28 0 cytoplasm cytoplasm Amniota Euteleostomi Euteleostomi PPP1R2 HGNC:9288 protein phosphatase 1, regulatory (inhibitor) subunit 2 P41236 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813) 9405437,9405437,12697755 nucleus 91 0 cytoplasm. nucleus multiple Bilateria Eukaryota Holozoa PPP1R21 HGNC:30595 protein phosphatase 1, regulatory subunit 21 Q6ZMI0 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota PPP1R26 HGNC:29089 protein phosphatase 1, regulatory subunit 26 Q5T8A7 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi PPP1R27 HGNC:16813 protein phosphatase 1, regulatory subunit 27 Q86WC6 cytoplasm 33 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms PPP1R32 HGNC:28869 protein phosphatase 1, regulatory subunit 32 Q7Z5V6 cytoplasm 23 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa PPP1R35 HGNC:28320 protein phosphatase 1, regulatory subunit 35 Q8TAP8 nucleus 59 0 nucleus nucleus Theria Euteleostomi Chordata PPP1R36 HGNC:20097 protein phosphatase 1, regulatory subunit 36 Q96LQ0 nucleus 50 0 nucleus nucleus Amniota Deuterostomia Eumetazoa PPP1R37 HGNC:27607 protein phosphatase 1, regulatory subunit 37 O75864 secreted 26 0 secreted secreted Bilateria Bilateria Cell.Organisms PPP1R3A HGNC:9291 protein phosphatase 1, regulatory subunit 3A Q16821 Membrane; Single-pass membrane protein (By similarity). Sarcoplasmic reticulum (GO:0016529) 12118251 nucleus 56 1 endoplasmic reticulum endoplasmic reticulum Amniota Euteleostomi Cell.Organisms PPP1R3B HGNC:14942 protein phosphatase 1, regulatory subunit 3B Q86XI6 cytoplasm 21 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms PPP1R3C HGNC:9293 protein phosphatase 1, regulatory subunit 3C Q9UQK1 Cytoplasm (GO:0005737) cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms PPP1R3D HGNC:9294 protein phosphatase 1, regulatory subunit 3D O95685 Cytoplasm (GO:0005737) nucleus 29 0 nucleus nucleus Amniota Bilateria Cell.Organisms PPP1R3E HGNC:14943 protein phosphatase 1, regulatory subunit 3E Q9H7J1 cytoplasm 25 0 cytoplasm cytoplasm NA NA Holozoa PPP1R3F HGNC:14944 protein phosphatase 1, regulatory subunit 3F Q6ZSY5 Membrane; Single-pass membrane protein (By similarity). nucleus 24 1 nucleus nucleus Eutheria Mammalia NA PPP1R3G HGNC:14945 protein phosphatase 1, regulatory subunit 3G B7ZBB8 nucleus 34 0 nucleus nucleus NA NA Eumetazoa PPP1R42 HGNC:33732 protein phosphatase 1, regulatory subunit 42 Q7Z4L9 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Colocalizes with alpha tubulin to the manchette of developing spermatids. Detected to nuclear rim in pachytene spermatocytes. Detected at nuclear surface, opposite the acrosome in elongating spermatids. Detected at the microtubule- organizing center (MTOC). Localized to the centrosomal region of late-stage spermatids (By similarity). cytoplasm 79 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms PPP1R7 HGNC:9295 protein phosphatase 1, regulatory subunit 7 Q15435 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7498485,7498485 nucleus 94 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms PPP1R8 HGNC:9296 protein phosphatase 1, regulatory subunit 8 Q12972 Nucleus. Nucleus speckle. Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11034904,11034904 nucleus 21 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms PPP1R9A HGNC:14946 protein phosphatase 1, regulatory subunit 9A Q9ULJ8 Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoskeleton (GO:0005856) 9362513,12052877 secreted 28 0 secreted secreted Bilateria Bilateria Holozoa PPP1R9B HGNC:9298 protein phosphatase 1, regulatory subunit 9B Q96SB3 Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse. Cell junction, adherens junction (By similarity). Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9275233,12417592,11278317 secreted 21 0 cytoplasm. nucleus multiple Mammalia Euteleostomi NA PPP2CA HGNC:9299 protein phosphatase 2, catalytic subunit, alpha isozyme P67775 Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). Cytoplasm (GO:0005737); Chromosome (GO:0005694); Mitochondrion (GO:0005739) ,16541025,15598749 cytoplasm 76 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP2CB HGNC:9300 protein phosphatase 2, catalytic subunit, beta isozyme P62714 Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10781942,10781942 cytoplasm 76 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP2R1A HGNC:9302 protein phosphatase 2, regulatory subunit A, alpha P30153 Cytoplasm (By similarity). Chromosome, centromere. Note=Centromeric localization requires the presence of BUB1. Cytoplasm (GO:0005737); Chromosome (GO:0005694); Membrane fraction (GO:0005624); Microtubule (GO:0005874) 17374643,17540176,16541025,17540176,15561729 cytoplasm 49 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP2R1B HGNC:9303 protein phosphatase 2, regulatory subunit A, beta P30154 Membrane fraction (GO:0005624); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Microtubule (GO:0005874) 17540176,11531413,17540176,11531413,15561729 cytoplasm 48 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA PPP2R2A HGNC:9304 protein phosphatase 2, regulatory subunit B, alpha P63151 Cytoplasm (GO:0005737); Chromosome (GO:0005694) 9514514,16541025 cytoplasm 87 0 cytoplasm. nucleus multiple NA NA Eukaryota PPP2R2B HGNC:9305 protein phosphatase 2, regulatory subunit B, beta Q00005 Isoform 1: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Membrane (By similarity). Isoform 2: Cytoplasm (By similarity). Mitochondrion (By similarity). Mitochondrion outer membrane (By similarity). Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9514514,9514514 cytoplasm 82 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PPP2R2C HGNC:9306 protein phosphatase 2, regulatory subunit B, gamma Q9Y2T4 Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 9514514,10945473,9514514 cytoplasm 80 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PPP2R2D HGNC:23732 protein phosphatase 2, regulatory subunit B, delta Q66LE6 Cytoplasm (By similarity). cytoplasm 96 0 cytoplasm cytoplasm Eukaryota Eukaryota NA PPP2R3A HGNC:9307 protein phosphatase 2, regulatory subunit B'', alpha Q06190 Nucleus (GO:0005634) 12524438 nucleus 58 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PPP2R3B HGNC:13417 protein phosphatase 2, regulatory subunit B'', beta Q9Y5P8 Nucleus. Nucleus (GO:0005634) 10629059 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PPP2R3C HGNC:17485 protein phosphatase 2, regulatory subunit B'', gamma Q969Q6 Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. cytoplasm 24 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota PPP2R4 HGNC:9308 protein phosphatase 2A activator, regulatory subunit 4 Q15257 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 3017441,7721943,7721943 cytoplasm 24 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PPP2R5A HGNC:9309 protein phosphatase 2, regulatory subunit B', alpha Q15172 Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. Cytoplasm (GO:0005737); Chromosome (GO:0005694) ,8703017,,16541024,16541025 cytoplasm 73 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota PPP2R5B HGNC:9310 protein phosphatase 2, regulatory subunit B', beta Q15173 Cytoplasm. Cytoplasm (GO:0005737); Chromosome (GO:0005694) ,8703017,,16541024 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota PPP2R5C HGNC:9311 protein phosphatase 2, regulatory subunit B', gamma Q13362 Nucleus. Chromosome, centromere. Chromosome (GO:0005694);Nucleus (GO:0005634) 16541024/,8703017, nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota PPP2R5D HGNC:9312 protein phosphatase 2, regulatory subunit B', delta Q14738 Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis. Chromosome (GO:0005694); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874);Cytoplasm (GO:0005737) 16541024,8703017,8703017,15561729/17081983 nucleus 76 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota PPP2R5E HGNC:9313 protein phosphatase 2, regulatory subunit B', epsilon isoform Q16537 Cytoplasm. Cytoplasm (GO:0005737); Chromosome (GO:0005694) ,8703017,,16541024 cytoplasm 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota PPP3CA HGNC:9314 protein phosphatase 3, catalytic subunit, alpha isozyme Q08209 Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10089876,7593193,15757646 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP3CB HGNC:9315 protein phosphatase 3, catalytic subunit, beta isozyme P16298 Cytoplasm (GO:0005737) 7593193 nucleus 81 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PPP3CC HGNC:9316 protein phosphatase 3, catalytic subunit, gamma isozyme P48454 nucleus 78 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms PPP3R1 HGNC:9317 protein phosphatase 3, regulatory subunit B, alpha P63098 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 10959817,11982754,11982754 cytoplasm 20 0 cytoplasm. nucleus multiple NA NA Cell.Organisms PPP3R2 HGNC:9318 protein phosphatase 3, regulatory subunit B, beta Q96LZ3 cytoplasm 25 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PPP4C HGNC:9319 protein phosphatase 4, catalytic subunit P60510 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus (GO:0005634); Centrosome (GO:0005813); Cytoplasm (GO:0005737) 9359419,8384557,18715871,8384557,8384557,18715871 mitochondrion 78 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP4R1 HGNC:9320 protein phosphatase 4, regulatory subunit 1 Q8TF05 Centrosome (GO:0005813) 8384557 cytoplasm 12 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PPP4R2 HGNC:18296 protein phosphatase 4, regulatory subunit 2 Q9NY27 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2. Centrosome (GO:0005813); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10769191,10769191,10769191 golgi apparatus membrane 11 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota PPP4R4 HGNC:23788 protein phosphatase 4, regulatory subunit 4 Q6NUP7 Cytoplasm. Cytoplasm (GO:0005737) 18715871 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota PPP5C HGNC:9322 protein phosphatase 5, catalytic subunit P53041 Nucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 7925273,10400612,12176367 cytoplasm 30 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PPP5D1 HGNC:44209 PPP5 tetratricopeptide repeat domain containing 1 E7EU14 cytoplasm 25 0 cytoplasm cytoplasm NA NA Eukaryota PPP6C HGNC:9323 protein phosphatase 6, catalytic subunit O00743 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9013334,,18186651, cytoplasm 100 0 cytoplasm. nucleus multiple Human Eukaryota Cell.Organisms PPP6R1 HGNC:29195 protein phosphatase 6, regulatory subunit 1 Q9UPN7 Cytoplasm. Cytoplasm (GO:0005737) ,17081983,18186651, cytoplasm 100 2 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota PPP6R2 HGNC:19253 protein phosphatase 6, regulatory subunit 2 O75170 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota PPP6R3 HGNC:1173 protein phosphatase 6, regulatory subunit 3 Q5H9R7 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) ,11401438,17081983,18186651,,17081983 cytoplasm 39 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota PPRC1 HGNC:30025 peroxisome proliferator-activated receptor gamma, coactivator-related 1 Q5VV67 Nucleus. Note=Colocalizes with NRF1 (By similarity). Nucleus (GO:0005634) 11340167 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa PPT1 HGNC:9325 palmitoyl-protein thioesterase 1 P50897 Lysosome. Lysosome (GO:0005764) 11440996 secreted 81 0 lysosome lysosome Opisthokonta Eukaryota Eukaryota PPT2 HGNC:9326 palmitoyl-protein thioesterase 2 Q9UMR5 Lysosome. Lysosome (GO:0005764) 9341199,11717424 secreted 81 0 lysosome lysosome Deuterostomia Eukaryota NA PPTC7 HGNC:30695 PTC7 protein phosphatase homolog (S. cerevisiae) Q8NI37 mitochondrion 24 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota PPWD1 HGNC:28954 peptidylprolyl isomerase domain and WD repeat containing 1 Q96BP3 Nucleus. Note=Associated with spliceosomal complexes. nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms PPY HGNC:9327 pancreatic polypeptide P01298 Secreted. Extracellular (GO:0005576) 2997153 secreted 100 0 secreted secreted Theria Theria Craniata PQBP1 HGNC:9330 polyglutamine binding protein 1 O60828 Nucleus. Note=Co-localized with POU3F2. Co- localized with ATXN1 in nuclear inclusion bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10198427,10593949,10332029,15635413 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota NA PQLC1 HGNC:26188 PQ loop repeat containing 1 Q8N2U9 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 18 7 vacuole membrane vacuole membrane Eukaryota Eukaryota Eukaryota PQLC2 HGNC:26001 PQ loop repeat containing 2 Q6ZP29 Lysosome membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) vacuole membrane 20 7 lysosome membrane lysosome membrane Opisthokonta Eukaryota Eukaryota PQLC3 HGNC:28503 PQ loop repeat containing 3 Q8N755 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 40 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Opisthokonta PRAC1 HGNC:30591 prostate cancer susceptibility candidate 1 Q96KF2 Nucleus. Nucleus (GO:0005634) 11340635 nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Boreoeutheria PRADC1 HGNC:16047 protease-associated domain containing 1 Q9BSG0 Secreted. Extracellular (GO:0005576); Golgi apparatus (GO:0005794) 12975309,15498570,15498570 secreted 100 0 golgi apparatus. secreted multiple Theria Bilateria Cell.Organisms PRAF2 HGNC:28911 PRA1 domain family, member 2 O60831 Endosome membrane; Multi-pass membrane protein (Probable). endoplasmic reticulum membrane 43 4 endosome membrane endosome membrane NA NA Bilateria PRAM1 HGNC:30091 PML-RARA regulated adaptor molecule 1 Q96QH2 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8806687,17081983,17081983 cytoplasm 18 0 cytoplasm. nucleus multiple Eutheria Amniota Cell.Organisms PRAME HGNC:9336 preferentially expressed antigen in melanoma P78395 Nucleus (Probable). Cell membrane. nucleus 80 0 nucleus nucleus Eutheria Eutheria Bilateria PRAMEF1 HGNC:28840 PRAME family member 1 O95521 nucleus 79 0 nucleus nucleus Catarrhini Catarrhini Bilateria PRAMEF10 HGNC:27997 PRAME family member 10 O60809 nucleus 80 0 nucleus nucleus Catarrhini Catarrhini Bilateria PRAMEF11 HGNC:14086 PRAME family member 11 O60813 nucleus 77 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF12 HGNC:22125 PRAME family member 12 O95522 nucleus 75 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF13 HGNC:13262 PRAME family member 13 Q5VWM6 nucleus 78 0 nucleus nucleus Catarrhini Catarrhini Bilateria PRAMEF15 HGNC:26764 PRAME family member 15 Q5VWM5 nucleus 80 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF16 HGNC:25767 PRAME family member 16 Q5VWM1 nucleus 80 0 nucleus nucleus Catarrhini Catarrhini Bilateria PRAMEF17 HGNC:29485 PRAME family member 17 Q5VTA0 nucleus 80 0 nucleus nucleus Catarrhini Catarrhini Bilateria PRAMEF18 HGNC:30693 PRAME family member 18 Q5VWM3 nucleus 72 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF19 HGNC:24908 PRAME family member 19 Q5SWL8 nucleus 70 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF2 HGNC:28841 PRAME family member 2 O60811 nucleus 84 0 nucleus nucleus Catarrhini Catarrhini Bilateria PRAMEF20 HGNC:25224 PRAME family member 20 Q5VT98 nucleus 81 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF21 HGNC:22405 PRAME family member 21 Q5VT98 nucleus 81 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF22 HGNC:34393 PRAME family member 22 A3QJZ6 nucleus 71 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF23 HGNC:34394 PRAME family member 23 A6NMV5 nucleus 80 0 nucleus nucleus NA NA NA PRAMEF26 HGNC:49178 PRAME family member 26 H0Y7S4 nucleus 71 0 nucleus nucleus NA NA Euteleostomi PRAMEF3 HGNC:14087 PRAME family member 3 Q5TYW8 nucleus 65 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF4 HGNC:31971 PRAME family member 4 O60810 nucleus 79 0 nucleus nucleus NA NA Bilateria PRAMEF5 HGNC:27995 PRAME family member 5 Q5TYX0 nucleus 80 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF6 HGNC:30583 PRAME family member 6 Q5VXH4 nucleus 79 0 nucleus nucleus NA NA Bilateria PRAMEF7 HGNC:28415 PRAME family member 7 Q5VXH5 nucleus 78 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF8 HGNC:24074 PRAME family member 8 Q5VWM4 nucleus 79 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAMEF9 HGNC:27996 PRAME family member 9 Q5VWM5 nucleus 80 0 nucleus nucleus Catarrhini Eutheria Bilateria PRAP1 HGNC:23304 proline-rich acidic protein 1 Q96NZ9 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Euarchontoglires Eutheria Boreoeutheria PRB1 HGNC:9337 proline-rich protein BstNI subfamily 1 P04280 Secreted. Extracellular (GO:0005576) 9487127,1618808 secreted 100 0 secreted secreted NA NA NA PRB2 HGNC:9338 proline-rich protein BstNI subfamily 2 P02812 Secreted (By similarity). secreted 64 0 secreted secreted Human Human NA PRB3 HGNC:9339 proline-rich protein BstNI subfamily 3 Q04118 Secreted. Extracellular (GO:0005576) 1894623 secreted 100 0 secreted secreted Human Human NA PRB4 HGNC:9340 proline-rich protein BstNI subfamily 4 P10163 Secreted. Extracellular (GO:0005576) 9487127 secreted 100 0 secreted secreted NA NA NA PRC1 HGNC:9341 protein regulator of cytokinesis 1 O43663 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Microtubule (GO:0005874);Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Microtubule cytoskeleton (GO:0015630); Extracellular space (GO:0005615); Microtubule (GO:0005874) 15561729/9885575,14744859,9885575,15297875,15625105,14744859,14744859,15561729 cytoplasm 10 0 cytoplasm. nucleus. secreted multiple Opisthokonta Eukaryota Eukaryota PRCC HGNC:9343 papillary renal cell carcinoma (translocation-associated) Q92733 Nucleus. Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10644981,17081983,14718574,17081983 nucleus 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Deuterostomia Holozoa PRCD HGNC:32528 progressive rod-cone degeneration Q00LT1 Membrane; Single-pass membrane protein (Potential). Cytoplasm. Perinuclear region (GO:0048471) 16938425 secreted 73 0 cytoplasm cytoplasm Homininae Eutheria Boreoeutheria PRCP HGNC:9344 prolylcarboxypeptidase (angiotensinase C) P42785 Lysosome. Lysosome (GO:0005764); Extracellular matrix (GO:0005578) 14996700,8344943,12123826,14996700 cytoplasm 10 0 lysosome. secreted multiple Bilateria Eukaryota Eukaryota PRDM1 HGNC:9346 PR domain containing 1, with ZNF domain O75626 Nucleus (By similarity). Cytoplasm. Nucleus (GO:0005634) 8168136 nucleus 27 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota PRDM10 HGNC:13995 PR domain containing 10 Q9NQV6 Nucleus (By similarity). Nucleus (GO:0005634) 12175877 nucleus 93 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota PRDM11 HGNC:13996 PR domain containing 11 Q9NQV5 Nucleus (GO:0005634) nucleus 20 0 nucleus nucleus Amniota Amniota Metazoa PRDM12 HGNC:13997 PR domain containing 12 Q9H4Q4 Nucleus (Potential). nucleus 22 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota PRDM13 HGNC:13998 PR domain containing 13 Q9H4Q3 Nucleus (Potential). nucleus 18 0 nucleus nucleus Theria Bilateria Eukaryota PRDM14 HGNC:14001 PR domain containing 14 Q9GZV8 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota PRDM15 HGNC:13999 PR domain containing 15 P57071 Nucleus (Potential). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PRDM16 HGNC:14000 PR domain containing 16 Q9HAZ2 Nucleus. Nucleus (GO:0005634) 11050005 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota PRDM2 HGNC:9347 PR domain containing 2, with ZNF domain Q13029 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/9006946,7538672,10706618 nucleus 100 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Cell.Organisms PRDM4 HGNC:9348 PR domain containing 4 Q9UKN5 Nucleus (Potential). nucleus 25 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PRDM5 HGNC:9349 PR domain containing 5 Q9NQX1 Nucleus. Nucleus (GO:0005634) 15077163,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PRDM6 HGNC:9350 PR domain containing 6 Q9NQX0 Nucleus (By similarity). nucleus 90 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota PRDM7 HGNC:9351 PR domain containing 7 Q9NQW5 Nucleus (Potential). Chromosome (Potential). nucleus 30 0 nucleus nucleus NA NA Metazoa PRDM8 HGNC:13993 PR domain containing 8 Q9NQV8 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa PRDM9 HGNC:13994 PR domain containing 9 Q9NQV7 Nucleus (By similarity). Chromosome (By similarity). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Mammalia Bilateria Eukaryota PRDX1 HGNC:9352 peroxiredoxin 1 Q06830 Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9334312,9334312,15635413,15598749 cytoplasm 72 0 cytoplasm. melanosome. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PRDX2 HGNC:9353 peroxiredoxin 2 P32119 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10841776,10841776 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PRDX3 HGNC:9354 peroxiredoxin 3 P30048 Mitochondrion. Mitochondrion (GO:0005739) 11285261,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms PRDX4 HGNC:17169 peroxiredoxin 4 Q13162 Cytoplasm. Secreted. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 9388242,11358524,11358524,11358524,15598749 cytoplasm 63 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms PRDX5 HGNC:9355 peroxiredoxin 5 P30044 Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome. Mitochondrion (GO:0005739); Peroxisome (GO:0005777); Cytoplasm (GO:0005737); Lysosome (GO:0005764) 15304327,10514471,10521424,15304327,10514471,10521424,15304327,10514471,10514471 cytoplasm 28 0 cytoplasm. lysosome. mitochondrion. peroxisome multiple Opisthokonta Cell.Organisms Cell.Organisms PRDX6 HGNC:16753 peroxiredoxin 6 P30041 Cytoplasm. Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Also found in lung secretory organelles (By similarity). Cytoplasm (GO:0005737); Lysosome (GO:0005764) 12650976,9497358,8999971 nucleus 40 0 cytoplasm. lysosome multiple Cell.Organisms Cell.Organisms Cell.Organisms PREB HGNC:9356 prolactin regulatory element binding Q9HCU5 Nucleus (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) nucleus 23 2 nucleus nucleus Mammalia Eukaryota Cell.Organisms PRELID1 HGNC:30255 PRELI domain containing 1 Q9Y255 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Opisthokonta Eukaryota PRELID2 HGNC:28306 PRELI domain containing 2 Q8N945 mitochondrion 5 0 mitochondrion mitochondrion Mammalia Deuterostomia Eukaryota PRELP HGNC:9357 proline/arginine-rich end leucine-rich repeat protein P51888 Secreted, extracellular space, extracellular matrix. Extracellular matrix (GO:0005578) 11847210,7592739 secreted 100 0 secreted secreted Amniota Euteleostomi Cell.Organisms PREP HGNC:9358 prolyl endopeptidase P48147 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 7959018,11792464,11792464,11792464 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms PREPL HGNC:30228 prolyl endopeptidase-like Q4J6C6 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms PREX1 HGNC:32594 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Q8TCU6 Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11955434,11955434 cytoplasm 21 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms PREX2 HGNC:22950 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 Q70Z35 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 15304343,15304343 nucleus 21 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms PRF1 HGNC:9360 perforin 1 (pore forming protein) P14222 Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 1505959,11586066,15576364 secreted 13 0 cytoplasm. endosome. plasma membrane. secreted multiple Euteleostomi Euteleostomi Eukaryota PRG2 HGNC:9362 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) P13727 Bone marrow proteoglycan: Secreted. Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). Extracellular (GO:0005576) 3422083 secreted 17 0 secreted secreted Euarchontoglires Mammalia Cell.Organisms PRG3 HGNC:9363 proteoglycan 3 Q9Y2Y8 Cytoplasmic granule. Note=Localized to the eosinophil secondary granule. Extracellular (GO:0005576) 10318872 secreted 18 0 secreted secreted Theria Amniota Cell.Organisms PRG4 HGNC:9364 proteoglycan 4 Q92954 Secreted. Extracellular (GO:0005576);Nucleus (GO:0005634) 10545950,16188874/17081983 secreted 100 0 nucleus. secreted multiple Euteleostomi Euteleostomi Holozoa PRH1 HGNC:9366 proline-rich protein HaeIII subfamily 1 P02810 Secreted. Extracellular (GO:0005576) 803013 secreted 100 0 secreted secreted NA NA Homo PRH2 HGNC:9367 proline-rich protein HaeIII subfamily 2 P02810 Secreted. Extracellular (GO:0005576) 2993301 secreted 100 0 secreted secreted Human Human NA PRICKLE1 HGNC:17019 prickle homolog 1 (Drosophila) Q96MT3 Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14645515,14645515 nucleus 14 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota PRICKLE2 HGNC:20340 prickle homolog 2 (Drosophila) Q7Z3G6 Nucleus membrane (Potential). nucleus 15 0 nucleus nucleus Chordata Bilateria Eukaryota PRICKLE3 HGNC:6645 prickle homolog 3 (Drosophila) O43900 Nucleus (GO:0005634) none,17081983 cytoplasm 15 0 cytoplasm cytoplasm Eutheria Deuterostomia Eukaryota PRICKLE4 HGNC:16805 prickle homolog 4 (Drosophila) Q2TBC4 cytoplasm 22 0 cytoplasm cytoplasm Theria Theria Eukaryota PRIM1 HGNC:9369 primase, DNA, polypeptide 1 (49kDa) P49642 Nucleus (GO:0005634) cytoplasm 31 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PRIM2 HGNC:9370 primase, DNA, polypeptide 2 (58kDa) P49643 Nucleus (GO:0005634) nucleus 26 0 nucleus nucleus Eukaryota Eukaryota NA PRIMA1 HGNC:18319 proline rich membrane anchor 1 Q86XR5 Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction (By similarity). Cell junction, synapse (By similarity). Note=In the brain, PRIMA linked to ACHE is found in membrane rafts (By similarity). Plasma membrane (GO:0005886) 11804574 secreted 84 1 plasma membrane plasma membrane Eutheria Amniota Euteleostomi PRIMPOL HGNC:26575 primase and polymerase (DNA-directed) Q96LW4 nucleus 56 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota PRKAA1 HGNC:9376 protein kinase, AMP-activated, alpha 1 catalytic subunit Q13131 Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters. Cytoplasm (GO:0005737) 10760274 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRKAA2 HGNC:9377 protein kinase, AMP-activated, alpha 2 catalytic subunit P54646 Cytoplasm (By similarity). Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10760274,10760274 secreted 32 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRKAB1 HGNC:9378 protein kinase, AMP-activated, beta 1 non-catalytic subunit Q9Y478 Cytoplasm (GO:0005737) cytoplasm 24 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Cell.Organisms PRKAB2 HGNC:9379 protein kinase, AMP-activated, beta 2 non-catalytic subunit O43741 Cytoplasm (GO:0005737) cytoplasm 22 0 cytoplasm cytoplasm Eukaryota Eukaryota NA PRKACA HGNC:9380 protein kinase, cAMP-dependent, catalytic, alpha P17612 Cytoplasm. Cell membrane. Nucleus (By similarity). Mitochondrion (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Golgi apparatus (GO:0005794); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8816779,8816779/17081983,17081983 nucleus 27 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PRKACB HGNC:9381 protein kinase, cAMP-dependent, catalytic, beta P22694 Cytoplasm. Cell membrane. Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 26 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PRKACG HGNC:9382 protein kinase, cAMP-dependent, catalytic, gamma P22612 Cytoplasm (GO:0005737) cytoplasm 26 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PRKAG1 HGNC:9385 protein kinase, AMP-activated, gamma 1 non-catalytic subunit P54619 mitochondrion 15 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms PRKAG2 HGNC:9386 protein kinase, AMP-activated, gamma 2 non-catalytic subunit Q9UGJ0 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10698692,10698692 nucleus 20 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PRKAG3 HGNC:9387 protein kinase, AMP-activated, gamma 3 non-catalytic subunit Q9UGI9 cytoplasm 7 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms PRKAR1A HGNC:9388 protein kinase, cAMP-dependent, regulatory, type I, alpha P10644 Cell membrane. Cytoplasm (GO:0005737) 12475780,11414803,17369818 cytoplasm 49 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms PRKAR1B HGNC:9390 protein kinase, cAMP-dependent, regulatory, type I, beta P31321 Cell membrane. Cytoplasm (GO:0005737) 12373096 cytoplasm 49 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms PRKAR2A HGNC:9391 protein kinase, cAMP-dependent, regulatory, type II, alpha P13861 Cytoplasm. Cell membrane. Note=Co-localizes with PJA2 in the cytoplasm and the cell membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7893490,11414803,17081983,11414803,17081983 cytoplasm 42 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms PRKAR2B HGNC:9392 protein kinase, cAMP-dependent, regulatory, type II, beta P31323 Cytoplasm. Cell membrane. Note=Co-localizes with PJA2 in the cytoplasm and at the cell membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 7479855,11591815,1582408 cytoplasm 36 0 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms PRKCA HGNC:9393 protein kinase C, alpha P17252 Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein (Probable). Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Synapse (GO:0045202); Perinuclear region (GO:0048471) 12135703,17081983,9624226,14670076,16628218,16221682,14670076,12943720,16221682,10027300,16923831 cytoplasm 65 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Cell.Organisms PRKCB HGNC:9395 protein kinase C, beta P05771 Cytoplasm (By similarity). Nucleus. Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12167592,10828076,7716516,9475183,12167592,10828076,7716516,11179083,7716516 cytoplasm 66 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Cell.Organisms PRKCD HGNC:9399 protein kinase C, delta Q05655 Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell membrane; Peripheral membrane protein. Cytosol (GO:0005829); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11571229,12193405,11571229,12147630,12943720,12147630,12943720 cytoplasm 40 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Bilateria Bilateria NA PRKCDBP HGNC:9400 protein kinase C, delta binding protein Q969G5 Nucleus (GO:0005634) 17081983 cytoplasm 12 0 nucleus nucleus Theria Theria Euteleostomi PRKCE HGNC:9401 protein kinase C, epsilon Q02156 Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11877428,11809819 cytoplasm 58 0 cytoplasm. golgi apparatus multiple Opisthokonta Opisthokonta Cell.Organisms PRKCG HGNC:9402 protein kinase C, gamma P05129 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Cell projection, dendrite (By similarity). Note=Translocates to synaptic membranes on stimulation (By similarity). Membrane fraction (GO:0005624); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 15459208,9786959,9786959,9786959,18716283,15459208 cytoplasm 60 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Cell.Organisms PRKCH HGNC:9403 protein kinase C, eta P24723 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11727958 cytoplasm 97 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Cell.Organisms PRKCI HGNC:9404 protein kinase C, iota P41743 Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Microsome (GO:0005792) 10567402,10567402,15581361,17203073,15581361 cytoplasm 49 0 cytoplasm. endosome. nucleus multiple Bilateria Cell.Organisms Cell.Organisms PRKCQ HGNC:9410 protein kinase C, theta Q04759 Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9260867,9260867,8816492 cytoplasm 31 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms PRKCSH HGNC:9411 protein kinase C substrate 80K-H P14314 Endoplasmic reticulum (Potential). Endoplasmic reticulum (GO:0005783) 1076483,15133510 endoplasmic reticulum 79 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota PRKCZ HGNC:9412 protein kinase C, zeta Q05513 Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Membrane fraction (GO:0005624); Late endosome (GO:0005770); Microsome (GO:0005792); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cell junction (GO:0030054) 7925449,9566925,11740573,7925449,12139760,11740573,17081983,12139760,17057644 cytoplasm 47 0 cytoplasm. endosome. nucleus multiple Bilateria Cell.Organisms Cell.Organisms PRKD1 HGNC:9407 protein kinase D1 Q15139 Cytoplasm. Cell membrane. Golgi apparatus, trans-Golgi network (By similarity). Note=Translocation to the cell membrane is required for kinase activation. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 11641411,11641411,11549247,11691822,11549247,11549247 nucleus 20 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms PRKD2 HGNC:17293 protein kinase D2 Q9BZL6 Cytoplasm. Cell membrane (By similarity). Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12646243,12646243 cytoplasm 20 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Cell.Organisms PRKD3 HGNC:9408 protein kinase D3 O94806 Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation. Cytosol (GO:0005829); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Peroxisome (GO:0005777); Endosome (GO:0005768); Lysosome (GO:0005764) 17196367,17196367,17196367,17196367,17196367,17081983,17196367,17196367,17196367,17196367,17196367 nucleus 18 0 cytoplasm. endosome. golgi apparatus. lysosome. mitochondrion. nucleus. peroxisome multiple Bilateria Bilateria Cell.Organisms PRKDC HGNC:9413 protein kinase, DNA-activated, catalytic polypeptide P78527 Nucleus. Nucleus, nucleolus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytosol (GO:0005829); Microsome (GO:0005792); Mitochondrion (GO:0005739);Nucleus (GO:0005634) 10547363,10547363,16221682,15561729,15635413,11790298,16263121,16221682,15598749/17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple NA NA Eukaryota PRKG1 HGNC:9414 protein kinase, cGMP-dependent, type I Q13976 Cytoplasm (By similarity). Note=Colocalized with TRPC7 in the plasma membrane (By similarity). Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Perinuclear region (GO:0048471) 10671526,11175347,15051728 nucleus 22 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Eukaryota Cell.Organisms PRKG2 HGNC:9416 protein kinase, cGMP-dependent, type II Q13237 Apical cell membrane; Lipid-anchor. Plasma membrane (GO:0005886) 7543493 nucleus 20 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms PRKRA HGNC:9438 protein kinase, interferon-inducible double stranded RNA dependent activator O75569 Cytoplasm, perinuclear region. Cytoplasm. Cytoplasm (GO:0005737) 16424907,17081983 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Bilateria Metazoa PRKRIP1 HGNC:21894 PRKR interacting protein 1 (IL11 inducible) Q9H875 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 12679338,12679338,12679338 nucleus 93 0 cytoplasm. nucleus multiple Human Opisthokonta NA PRKRIR HGNC:9440 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) O43422 Nucleus (GO:0005634) 12384512 nucleus 20 1 nucleus nucleus Chordata Chordata Eukaryota PRKX HGNC:9441 protein kinase, X-linked P51817 Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation. Cytoplasm (GO:0005737) 10026146 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PRL HGNC:9445 prolactin P01236 Secreted. Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 743954,743954,743954 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Euteleostomi Bilateria PRLH HGNC:17945 prolactin releasing hormone P81277 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Eutheria Amniota Euteleostomi PRLHR HGNC:4464 prolactin releasing hormone receptor P49683 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9607765 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa PRLR HGNC:9446 prolactin receptor P16471 Membrane; Single-pass type I membrane protein. Isoform 7: Secreted. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 1559983,7706371 secreted 25 1 nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Bilateria PRM1 HGNC:9447 protamine 1 P04553 Nucleus. Chromosome. Nucleus (GO:0005634) 8466000 nucleus 100 0 nucleus nucleus Human Human NA PRM2 HGNC:9448 protamine 2 P04554 Nucleus. Chromosome. Nucleus (GO:0005634) 7714151 nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Primates PRM3 HGNC:13732 protamine 3 Q9NNZ6 Nucleus (By similarity). Chromosome (By similarity). nucleus 70 0 nucleus nucleus Euarchontoglires Eutheria Eutheria PRMT1 HGNC:5187 protein arginine methyltransferase 1 Q99873 Nucleus. Nucleus, nucleoplasm (By similarity). Cytoplasm, cytosol (By similarity). Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11448779,11152681,10749851,17053781,8663146,17053781 cytoplasm 38 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRMT2 HGNC:5186 protein arginine methyltransferase 2 P55345 Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Nucleus (GO:0005634) 11513728 cytoplasm 25 0 cytoplasm. nucleus multiple Eutheria Eukaryota Cell.Organisms PRMT3 HGNC:30163 protein arginine methyltransferase 3 O60678 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Ribosome (GO:0005840) 9642256,,15175657 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Opisthokonta Cell.Organisms PRMT5 HGNC:10894 protein arginine methyltransferase 5 O14744 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 11152681 nucleus 28 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRMT6 HGNC:18241 protein arginine methyltransferase 6 Q96LA8 Nucleus. Nucleus (GO:0005634) 11724789 nucleus 100 0 nucleus nucleus Theria Cell.Organisms Cell.Organisms PRMT7 HGNC:25557 protein arginine methyltransferase 7 Q9NVM4 Cytoplasm, cytosol. Nucleus. cytoplasm 12 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms PRMT8 HGNC:5188 protein arginine methyltransferase 8 Q9NR22 Cell membrane; Lipid-anchor; Cytoplasmic side. cytoplasm 35 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PRMT9 HGNC:25099 protein arginine methyltransferase 9 Q6P2P2 cytoplasm 14 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms PRND HGNC:15748 prion protein 2 (dublet) Q9UKY0 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). secreted 68 1 secreted secreted Theria Theria Mammalia PRNP HGNC:9449 prion protein P04156 Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Isoform 2: Cytoplasm. Nucleus. Note=Accumulates outside the secretory route in the cytoplasm, from where it relocates to the nucleus. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 8962161,12093732,17872899,11278562,10970892,11278562,11278562,14645231 cytoplasm 40 2 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus. plasma membrane. secreted multiple Tetrapoda Tetrapoda Tetrapoda PROB1 HGNC:41906 proline-rich basic protein 1 E7EW31 secreted 11 0 secreted secreted NA NA Euteleostomi PROC HGNC:9451 protein C (inactivator of coagulation factors Va and VIIIa) P04070 Extracellular (GO:0005576) 9334197,2033065 secreted 28 0 secreted secreted Euteleostomi Bilateria Cell.Organisms PROCA1 HGNC:28600 protein interacting with cyclin A1 Q8NCQ7 nucleus 82 0 nucleus nucleus Human Eutheria Chordata PROCR HGNC:9452 protein C receptor, endothelial Q9UNN8 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Centrosome (GO:0005813) 1051893,10518938 secreted 41 1 plasma membrane plasma membrane Amniota Amniota Amniota PRODH HGNC:9453 proline dehydrogenase (oxidase) 1 O43272 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms PRODH2 HGNC:17325 proline dehydrogenase (oxidase) 2 Q9UF12 Mitochondrion (GO:0005739) 11959925 mitochondrion 32 0 mitochondrion mitochondrion NA NA Cell.Organisms PROK1 HGNC:18454 prokineticin 1 P58294 Secreted. Extracellular (GO:0005576) 11528470 secreted 100 0 secreted secreted Amniota Euteleostomi Bilateria PROK2 HGNC:18455 prokineticin 2 Q9HC23 Secreted. Extracellular (GO:0005576) 11259612,14978236 secreted 100 0 secreted secreted Human Human Bilateria PROKR1 HGNC:4524 prokineticin receptor 1 Q8TCW9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10760605 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Eumetazoa PROKR2 HGNC:15836 prokineticin receptor 2 Q8NFJ6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Eumetazoa PROL1 HGNC:17279 proline rich, lacrimal 1 Q99935 Secreted. Extracellular (GO:0005576) 8670737 secreted 100 0 secreted secreted Catarrhini Catarrhini Primates PROM1 HGNC:9454 prominin 1 O43490 Cell projection, cilium, photoreceptor outer segment (By similarity). Isoform 1: Apical cell membrane; Multi-pass membrane protein (By similarity). Cell projection, microvillus membrane; Multi-pass membrane protein (By similarity). Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9389721,17081983 golgi apparatus membrane 68 5 nucleus. plasma membrane multiple Bilateria Bilateria Holozoa PROM2 HGNC:20685 prominin 2 Q8N271 Apical cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane; Multi-pass membrane protein (By similarity). Cell projection, microvillus membrane; Multi-pass membrane protein (By similarity). Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity). Plasma membrane (GO:0005886) 12514187 golgi apparatus membrane 66 5 plasma membrane plasma membrane Tetrapoda Tetrapoda Holozoa PROP1 HGNC:9455 PROP paired-like homeobox 1 O75360 Nucleus (By similarity). Nucleus (GO:0005634) 10199788 nucleus 30 0 nucleus nucleus Eutheria Eutheria Eukaryota PROS1 HGNC:9456 protein S (alpha) P07225 Secreted. Extracellular (GO:0005576) 6239102 secreted 100 0 secreted secreted Chordata Chordata Cell.Organisms PROSC HGNC:9457 proline synthetase co-transcribed homolog (bacterial) O94903 Cytoplasm (GO:0005737) 10496079 cytoplasm 51 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PROSER1 HGNC:20291 proline and serine rich 1 Q86XN7 nucleus 20 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa PROSER2 HGNC:23728 proline and serine rich 2 Q86WR7 Nucleus (GO:0005634) 15302935 nucleus 50 0 nucleus nucleus Amniota Euteleostomi Euteleostomi PROX1 HGNC:9459 prospero homeobox 1 Q92786 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12060670,11850194,11850194 nucleus 53 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Bilateria PROX2 HGNC:26715 prospero homeobox 2 Q3B8N5 Nucleus (Probable). nucleus 47 0 nucleus nucleus Human Human Bilateria PROZ HGNC:9460 protein Z, vitamin K-dependent plasma glycoprotein P22891 Secreted. Extracellular (GO:0005576) 2040612,6707212 secreted 100 0 secreted secreted Tetrapoda Chordata Cell.Organisms PRPF18 HGNC:17351 pre-mRNA processing factor 18 Q99633 Nucleus speckle (By similarity). Note=Colocalizes with spliceosomal snRNPs (By similarity). Nucleus (GO:0005634) nucleus 19 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota PRPF19 HGNC:17896 pre-mRNA processing factor 19 Q9UMS4 Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing chromatin. Nucleus (GO:0005634); Nucleolus (GO:0005730) 15175653,11082287,15561729,15635413,11790298 nucleus 32 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRPF3 HGNC:17348 pre-mRNA processing factor 3 O43395 Nucleus speckle. Note=Colocalizes with spliceosomal snRNPs. Nucleus (GO:0005634); Nucleolus (GO:0005730); Ribosome (GO:0005840); Cytoplasm (GO:0005737) 9328476,17081983,15635413,15561729,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA PRPF31 HGNC:15446 pre-mRNA processing factor 31 Q8WWY3 Nucleus speckle. Nucleus, Cajal body. Note=Predominantly found in speckles and in Cajal bodies. Nucleus (GO:0005634) 11545739 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota NA PRPF38A HGNC:25930 pre-mRNA processing factor 38A Q8NAV1 Nucleus (Potential). nucleus 34 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PRPF38B HGNC:25512 pre-mRNA processing factor 38B Q5VTL8 Nucleus (Potential). nucleus 25 0 nucleus nucleus Bilateria Eukaryota Eukaryota PRPF39 HGNC:20314 pre-mRNA processing factor 39 Q86UA1 Nucleus (By similarity). nucleus 14 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota PRPF4 HGNC:17349 pre-mRNA processing factor 4 O43172 Nucleus speckle (By similarity). Note=Colocalizes with spliceosomal snRNPs (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Ribosome (GO:0005840) 9328476,11971898,11418604,19059367,11418604,15635413,15561729 cytoplasm 24 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRPF40A HGNC:16463 PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) O75400 Nucleus speckle (By similarity). Nucleus matrix. Note=Colocalizes with AKAP8L in the nuclear matrix (By similarity). Nucleus (GO:0005634); Nuclear matrix (GO:0016363);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14697212,9171351,16391387/17081983,17081983 nucleus 96 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PRPF40B HGNC:25031 PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) Q6NWY9 Nucleus speckle. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PRPF4B HGNC:17346 pre-mRNA processing factor 4B Q13523 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12077342,11418604,17513757,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PRPF6 HGNC:15860 pre-mRNA processing factor 6 O94906 Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles. Nucleus (GO:0005634) 10561546,12039962,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms PRPF8 HGNC:17340 pre-mRNA processing factor 8 Q6P2Q9 Nucleus speckle (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 15034300,10411133,15346200,15034300,15561729,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PRPH HGNC:9461 peripherin P41219 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9085149,8381395 cytoplasm 51 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa PRPH2 HGNC:9942 peripherin 2 (retinal degeneration, slow) P23942 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8956033 golgi apparatus membrane 53 4 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa PRPS1 HGNC:9462 phosphoribosyl pyrophosphate synthetase 1 P60891 cytoplasm 63 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PRPS1L1 HGNC:9463 phosphoribosyl pyrophosphate synthetase 1-like 1 P21108 cytoplasm 61 0 cytoplasm cytoplasm NA NA Cell.Organisms PRPS2 HGNC:9465 phosphoribosyl pyrophosphate synthetase 2 P11908 Cytoplasm (GO:0005737) 7572345 cytoplasm 62 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PRPSAP1 HGNC:9466 phosphoribosyl pyrophosphate synthetase-associated protein 1 Q14558 Cytoplasm (GO:0005737) none,17081983 cytoplasm 36 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms PRPSAP2 HGNC:9467 phosphoribosyl pyrophosphate synthetase-associated protein 2 O60256 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 36 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms PRR11 HGNC:25619 proline rich 11 Q96HE9 Cytoplasm. Nucleus (GO:0005634) 17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Tetrapoda Chordata Metazoa PRR12 HGNC:29217 proline rich 12 Q9ULL5 plasma membrane 32 0 n/a n/a Theria Tetrapoda Bilateria PRR13 HGNC:24528 proline rich 13 Q9NZ81 Nucleus. nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Primates PRR14 HGNC:28458 proline rich 14 Q9BWN1 nucleus 64 0 nucleus nucleus Mammalia Tetrapoda Olfactores PRR14L HGNC:28738 proline rich 14-like Q5THK1 nucleus 94 1 nucleus nucleus Chordata Chordata Olfactores PRR15 HGNC:22310 proline rich 15 Q8IV56 nucleus 70 0 nucleus nucleus Euarchontoglires Mammalia Euteleostomi PRR15L HGNC:28149 proline rich 15-like Q9BU68 nucleus 58 0 nucleus nucleus Mammalia Euteleostomi Craniata PRR16 HGNC:29654 proline rich 16 Q569H4 nucleus 76 0 nucleus nucleus Tetrapoda Euteleostomi Chordata PRR18 HGNC:28574 proline rich 18 Q8N4B5 secreted 9 0 secreted secreted Euarchontoglires Theria Mammalia PRR19 HGNC:33728 proline rich 19 A6NJB7 nucleus 78 0 nucleus nucleus Theria Theria Mammalia PRR20A HGNC:24754 proline rich 20A P86496 secreted 80 0 secreted secreted Catarrhini Catarrhini Primates PRR20B HGNC:37220 proline rich 20B P86481 secreted 80 0 secreted secreted Catarrhini Catarrhini Primates PRR20C HGNC:37221 proline rich 20C P86479 secreted 80 0 secreted secreted NA NA Primates PRR20D HGNC:37222 proline rich 20D P86480 secreted 80 0 secreted secreted NA NA Primates PRR20E HGNC:37223 proline rich 20E P86478 secreted 80 0 secreted secreted NA NA Primates PRR21 HGNC:33866 proline rich 21 Q8WXC7 secreted 45 1 secreted secreted NA NA Cell.Organisms PRR22 HGNC:28354 proline rich 22 Q8IZ63 nucleus 72 0 nucleus nucleus Theria Amniota Amniota PRR23A HGNC:37172 proline rich 23A A6NEV1 nucleus 48 0 nucleus nucleus Human Human Eutheria PRR23B HGNC:33764 proline rich 23B Q6ZRT6 nucleus 38 0 nucleus nucleus Euarchontoglires Eutheria Eutheria PRR23C HGNC:37173 proline rich 23C Q6ZRP0 secreted 34 0 secreted secreted NA NA Eutheria PRR23D1 HGNC:49420 proline rich 23 domain containing 1 E9PI22 secreted 51 0 secreted secreted NA NA Primates PRR23D2 HGNC:49396 proline rich 23 domain containing 2 P0DMB1 secreted 51 0 secreted secreted NA NA Primates PRR24 HGNC:27406 proline rich 24 C9JVW0 Membrane; Single-pass membrane protein (Potential). cytoplasm 23 1 cytoplasm cytoplasm NA NA Euarchontoglires PRR25 HGNC:37230 proline rich 25 Q96S07 secreted 13 0 secreted secreted NA NA Homo PRR26 HGNC:30724 proline rich 26 Q8N8Z3 secreted 24 0 secreted secreted Homininae Homininae Primates PRR27 HGNC:33193 proline rich 27 Q6MZM9 Secreted (Potential). nucleus 19 0 nucleus nucleus Catarrhini Catarrhini Eutheria PRR3 HGNC:21149 proline rich 3 P79522 nucleus 77 0 nucleus nucleus Eutheria Eutheria NA PRR4 HGNC:18020 proline rich 4 (lacrimal) Q16378 Secreted. Extracellular (GO:0005576) 7544782 secreted 100 0 secreted secreted Catarrhini Catarrhini NA PRR5 HGNC:31682 proline rich 5 (renal) P85299 nucleus 79 0 nucleus nucleus Eukaryota Eukaryota Opisthokonta PRR5L HGNC:25878 proline rich 5 like Q6MZQ0 nucleus 66 0 nucleus nucleus Amniota Euteleostomi Holozoa PRR7 HGNC:28130 proline rich 7 (synaptic) Q8TB68 Membrane; Single-pass type III membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (By similarity). nucleus 31 1 nucleus nucleus Theria Euteleostomi Euteleostomi PRR9 HGNC:32057 proline rich 9 Q5T870 secreted 92 0 secreted secreted Eutheria Eutheria Eutheria PRRC1 HGNC:28164 proline-rich coiled-coil 1 Q96M27 Golgi apparatus. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 15541471,15541471 golgi apparatus 100 0 cytoplasm. golgi apparatus multiple Euteleostomi Bilateria Eumetazoa PRRC2A HGNC:13918 proline-rich coiled-coil 2A P48634 Cytoplasm. Nucleus. nucleus 19 0 cytoplasm. nucleus multiple Theria Chordata NA PRRC2B HGNC:28121 proline-rich coiled-coil 2B Q5JSZ5 cytoplasm 17 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eumetazoa PRRC2C HGNC:24903 proline-rich coiled-coil 2C Q9Y520 Cytoplasm (GO:0005737) 12443540 nucleus 13 0 cytoplasm cytoplasm Mammalia Deuterostomia Eumetazoa PRRG1 HGNC:9469 proline rich Gla (G-carboxyglutamic acid) 1 O14668 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9256434 secreted 42 1 plasma membrane plasma membrane Euteleostomi Euteleostomi NA PRRG2 HGNC:9470 proline rich Gla (G-carboxyglutamic acid) 2 O14669 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9256434 secreted 43 1 plasma membrane plasma membrane Mammalia Tetrapoda Deuterostomia PRRG3 HGNC:30798 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) Q9BZD7 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11171957 secreted 34 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Olfactores PRRG4 HGNC:30799 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) Q9BZD6 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 11171957 secreted 30 1 secreted secreted Euteleostomi Euteleostomi Euteleostomi PRRT1 HGNC:13943 proline-rich transmembrane protein 1 Q99946 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse (By similarity). secreted 10 2 n/a n/a Mammalia Euteleostomi NA PRRT2 HGNC:30500 proline-rich transmembrane protein 2 Q7Z6L0 Cell membrane; Multi-pass membrane protein. Cell junction, synapse (By similarity). Integral to membrane (GO:0016021) secreted 36 2 plasma membrane plasma membrane Euarchontoglires Euteleostomi Euteleostomi PRRT3 HGNC:26591 proline-rich transmembrane protein 3 Q5FWE3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 23 7 cytoplasm cytoplasm Theria Theria Tetrapoda PRRT4 HGNC:37280 proline-rich transmembrane protein 4 C9JH25 Membrane; Multi-pass membrane protein (Potential). plasma membrane 92 7 plasma membrane plasma membrane NA NA Euteleostomi PRRX1 HGNC:9142 paired related homeobox 1 P54821 Nucleus. Nucleus (GO:0005634) 11463719 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota PRRX2 HGNC:21338 paired related homeobox 2 Q99811 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota PRSS1 HGNC:9475 protease, serine, 1 (trypsin 1) P07477 Secreted, extracellular space. Extracellular (GO:0005576) 12395893,12543931,14718574 secreted 100 0 secreted secreted Chordata Cell.Organisms NA PRSS12 HGNC:9477 protease, serine, 12 (neurotrypsin, motopsin) P56730 Secreted. Extracellular (GO:0005576) 9245503 secreted 100 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms PRSS16 HGNC:9480 protease, serine, 16 (thymus) Q9NQE7 Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PRSS2 HGNC:9483 protease, serine, 2 (trypsin 2) P07478 Secreted, extracellular space. Extracellular (GO:0005576) 11355948 secreted 100 0 secreted secreted NA NA Cell.Organisms PRSS21 HGNC:9485 protease, serine, 21 (testisin) Q9Y6M0 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10397266,10397266 secreted 32 0 cytoplasm cytoplasm Theria Theria Cell.Organisms PRSS22 HGNC:14368 protease, serine, 22 Q9GZN4 Secreted. secreted 100 0 secreted secreted Mammalia Mammalia Cell.Organisms PRSS23 HGNC:14370 protease, serine, 23 O95084 Secreted (Potential). secreted 21 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms PRSS27 HGNC:15475 protease, serine 27 Q9BQR3 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12441343,12441343 secreted 100 0 cytoplasm. secreted multiple Mammalia Bilateria Cell.Organisms PRSS3 HGNC:9486 protease, serine, 3 P35030 Secreted. secreted 100 0 secreted secreted Chordata Cell.Organisms Cell.Organisms PRSS33 HGNC:30405 protease, serine, 33 Q8NF86 Secreted (By similarity). Endoplasmic reticulum (GO:0005783) 12795636 secreted 76 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Cell.Organisms PRSS35 HGNC:21387 protease, serine, 35 Q8N3Z0 Secreted (Potential). secreted 78 0 secreted secreted Chordata Chordata Cell.Organisms PRSS36 HGNC:26906 protease, serine, 36 Q5K4E3 Secreted, extracellular space, extracellular matrix. Note=Not attached to membranes. Extracellular (GO:0005576) 15536082 secreted 100 1 secreted secreted Theria Euteleostomi Cell.Organisms PRSS37 HGNC:29211 protease, serine, 37 A4D1T9 Secreted (Potential). Nucleus (GO:0005634) 17081983 secreted 18 0 nucleus nucleus Theria Theria Cell.Organisms PRSS38 HGNC:29625 protease, serine, 38 A1L453 Secreted (Potential). secreted 29 1 secreted secreted Theria Theria Cell.Organisms PRSS42 HGNC:30716 protease, serine, 42 Q7Z5A4 Secreted (Potential). secreted 26 0 secreted secreted Theria Bilateria Cell.Organisms PRSS45 HGNC:30717 protease, serine, 45 Q7RTY3 secreted 27 0 secreted secreted Theria Theria Cell.Organisms PRSS46 HGNC:37325 protease, serine, 46 E5RG02 secreted 23 0 secreted secreted NA NA Cell.Organisms PRSS48 HGNC:24635 protease, serine, 48 Q7RTY5 Secreted (Potential). plasma membrane 29 0 n/a n/a Eutheria Eutheria Cell.Organisms PRSS50 HGNC:17910 protease, serine, 50 Q9UI38 Endoplasmic reticulum (Probable). Note=May also localize to cytoplasmic membranes. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11782390,11782390 cytoplasm 19 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eutheria Eutheria Cell.Organisms PRSS53 HGNC:34407 protease, serine, 53 Q2L4Q9 Secreted. secreted 100 0 secreted secreted Mammalia Tetrapoda Cell.Organisms PRSS54 HGNC:26336 protease, serine, 54 Q6PEW0 Secreted (Probable). secreted 10 0 secreted secreted Mammalia Mammalia Cell.Organisms PRSS55 HGNC:30824 protease, serine, 55 Q6UWB4 Membrane; Single-pass type I membrane protein (Potential). secreted 30 0 secreted secreted Amniota Bilateria Cell.Organisms PRSS56 HGNC:39433 protease, serine, 56 P0CW18 endoplasmic reticulum membrane 29 0 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA NA PRSS57 HGNC:31397 protease, serine, 57 Q6UWY2 Secreted (Potential). secreted 28 0 secreted secreted Amniota Amniota Cell.Organisms PRSS58 HGNC:39125 protease, serine, 58 Q8IYP2 Secreted (Potential). secreted 23 0 secreted secreted NA NA Cell.Organisms PRSS8 HGNC:9491 protease, serine, 8 Q16651 Prostasin: Cell membrane; Single-pass membrane protein. Prostasin light chain: Secreted, extracellular space. Prostasin heavy chain: Secreted, extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634) 11274175,11274175,11274175 plasma membrane 30 0 nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms PRTFDC1 HGNC:23333 phosphoribosyl transferase domain containing 1 Q9NRG1 cytoplasm 59 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms PRTG HGNC:26373 protogenin Q2VWP7 Membrane; Single-pass membrane protein (Potential). secreted 11 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms PRTN3 HGNC:9495 proteinase 3 P24158 Plasma membrane (GO:0005886); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 10498622,10498622,3513185,10498622 secreted 27 0 cytoplasm. lysosome multiple Homininae Tetrapoda Cell.Organisms PRUNE HGNC:13420 prune exopolyphosphatase Q86TP1 Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10602478,10602478 cytoplasm 20 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms PRUNE2 HGNC:25209 prune homolog 2 (Drosophila) Q8WUY3 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 2 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota PRX HGNC:13797 periaxin Q9BXM0 Nucleus (By similarity). Isoform 1: Cell membrane (By similarity). Isoform 2: Cytoplasm (By similarity). Nucleus (GO:0005634);Nucleus (GO:0005634); Plasma membrane (GO:0005886) 17081983/10671475,,10671475,11430802, nucleus 17 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms PRY HGNC:14024 PTPN13-like, Y-linked O14603 nucleus 12 0 nucleus nucleus Homininae Homininae Homo PRY2 HGNC:21504 PTPN13-like, Y-linked 2 O14603 nucleus 12 0 nucleus nucleus Homininae Homininae Homo PSAP HGNC:9498 prosaposin P07602 Lysosome. Lysosome (GO:0005764); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 1454804,1454804,16199891,1454804 secreted 62 0 lysosome. secreted multiple Deuterostomia Eukaryota Eukaryota PSAPL1 HGNC:33131 prosaposin-like 1 (gene/pseudogene) Q6NUJ1 Secreted (Potential). secreted 27 0 secreted secreted Catarrhini Eukaryota Eukaryota PSAT1 HGNC:19129 phosphoserine aminotransferase 1 Q9Y617 Cytosol (GO:0005829) 16263121 mitochondrion 40 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PSCA HGNC:9500 prostate stem cell antigen O43653 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 9465086 secreted 14 1 plasma membrane plasma membrane Catarrhini Amniota NA PSD HGNC:9507 pleckstrin and Sec7 domain containing A5PKW4 Cell membrane (By similarity). Cell projection, ruffle (By similarity). cytoplasm 22 0 cytoplasm cytoplasm Homininae Chordata Cell.Organisms PSD2 HGNC:19092 pleckstrin and Sec7 domain containing 2 Q9BQI7 Membrane; Single-pass membrane protein (Potential). cytoplasm 20 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms PSD3 HGNC:19093 pleckstrin and Sec7 domain containing 3 Q9NYI0 Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). cytoplasm 18 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms PSD4 HGNC:19096 pleckstrin and Sec7 domain containing 4 Q8NDX1 Cell membrane. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding. Plasma membrane (GO:0005886) 12082148 cytoplasm 18 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms PSEN1 HGNC:9508 presenilin 1 P49768 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note=Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact. Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Perinuclear region (GO:0048471); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Kinetochore (GO:0000776); Centrosome (GO:0005813); Nucleus (GO:0005634) 17081983,17081983/9298903,16306047,10341227,9013610,11076969,17081983,8574969,15549135,9013610,8574969,9013610,9298903,9298903,17081983 endoplasmic reticulum membrane 39 8 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. nucleus. plasma membrane multiple Eukaryota Eukaryota Eukaryota PSEN2 HGNC:9509 presenilin 2 P49810 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nuclear membrane (GO:0005635); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Kinetochore (GO:0000776) 9298903,10922078,9252383,10922078,9252383,9298903 endoplasmic reticulum membrane 27 9 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. nucleus membrane multiple Eukaryota Eukaryota Eukaryota PSENEN HGNC:30100 presenilin enhancer gamma secretase subunit Q9NZ42 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 14572442,12639958 mitochondrion membrane 36 2 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Theria Eukaryota Eukaryota PSG1 HGNC:9514 pregnancy specific beta-1-glycoprotein 1 P11464 Secreted (Potential). Secretory granule (GO:0030141); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 9290143,9290143,9290143,9290143 plasma membrane 23 0 endoplasmic reticulum. golgi apparatus multiple NA NA Metazoa PSG11 HGNC:9516 pregnancy specific beta-1-glycoprotein 11 Q9UQ72 Secreted (Potential). Extracellular (GO:0005576) plasma membrane 32 0 n/a n/a NA NA Metazoa PSG2 HGNC:9519 pregnancy specific beta-1-glycoprotein 2 P11465 Secreted (Potential). Plasma membrane (GO:0005886) plasma membrane 34 0 n/a n/a NA NA Metazoa PSG3 HGNC:9520 pregnancy specific beta-1-glycoprotein 3 Q16557 Secreted (Potential). secreted 19 0 secreted secreted NA NA Metazoa PSG4 HGNC:9521 pregnancy specific beta-1-glycoprotein 4 Q00888 Secreted (Potential). Extracellular (GO:0005576) 7794280 plasma membrane 22 0 secreted secreted NA NA Metazoa PSG5 HGNC:9522 pregnancy specific beta-1-glycoprotein 5 Q15238 Secreted (Potential). Extracellular (GO:0005576) plasma membrane 33 0 n/a n/a Amniota Euteleostomi Eumetazoa PSG6 HGNC:9523 pregnancy specific beta-1-glycoprotein 6 Q00889 Secreted (Potential). Extracellular (GO:0005576) secreted 20 0 secreted secreted Amniota Euteleostomi Metazoa PSG7 HGNC:9524 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) Q13046 Secreted (Potential). Extracellular (GO:0005576) plasma membrane 21 0 n/a n/a NA NA Cell.Organisms PSG8 HGNC:9525 pregnancy specific beta-1-glycoprotein 8 Q9UQ74 Secreted (Potential). secreted 23 0 secreted secreted Amniota Euteleostomi Metazoa PSG9 HGNC:9526 pregnancy specific beta-1-glycoprotein 9 Q00887 Secreted (Potential). Extracellular (GO:0005576) plasma membrane 22 0 n/a n/a Amniota Euteleostomi Metazoa PSIP1 HGNC:9527 PC4 and SFRS1 interacting protein 1 O75475 Nucleus. Note=Remains chromatin-associated throughout the cell cycle. Nucleus (GO:0005634); Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9822615,9885563,19059367,9885563,15308744/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota PSKH1 HGNC:9529 protein serine kinase H1 P11801 Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Centrosome (GO:0005813); Cytoplasm (GO:0005737) 12466556,11087665,11087665,11087665 nucleus 30 1 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Eukaryota Cell.Organisms PSKH2 HGNC:18997 protein serine kinase H2 Q96QS6 nucleus 26 1 nucleus nucleus Mammalia Bilateria Cell.Organisms PSMA1 HGNC:9530 proteasome (prosome, macropain) subunit, alpha type, 1 P25786 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1517242,9497851,1517242,9497851 nucleus 14 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMA2 HGNC:9531 proteasome (prosome, macropain) subunit, alpha type, 2 P25787 Cytoplasm. Nucleus. Cytoplasm, P-body (By similarity). Note=Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMA3 HGNC:9532 proteasome (prosome, macropain) subunit, alpha type, 3 P25788 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11341940,12826010,12826010 nucleus 18 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMA4 HGNC:9533 proteasome (prosome, macropain) subunit, alpha type, 4 P25789 Cytoplasm. Nucleus. Cytoplasm, P-body (By similarity). Note=Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 8687380,8687380,8687380 nucleus 47 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PSMA5 HGNC:9534 proteasome (prosome, macropain) subunit, alpha type, 5 P28066 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10363657,10363657 nucleus 19 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PSMA6 HGNC:9535 proteasome (prosome, macropain) subunit, alpha type, 6 P60900 Cytoplasm. Nucleus. Cytoplasm, P-body (By similarity). Note=Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Ribosome (GO:0005840) 9497851,10983987,9497851,8618844,7681138 nucleus 23 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMA7 HGNC:9536 proteasome (prosome, macropain) subunit, alpha type, 7 O14818 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 8764072,15987638,8764072,15635413 nucleus 20 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PSMA8 HGNC:22985 proteasome (prosome, macropain) subunit, alpha type, 8 Q8TAA3 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 26 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms PSMB1 HGNC:9537 proteasome (prosome, macropain) subunit, beta type, 1 P20618 Cytoplasm. Nucleus. cytoplasm 30 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMB10 HGNC:9538 proteasome (prosome, macropain) subunit, beta type, 10 P40306 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 10329130 nucleus 11 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PSMB11 HGNC:31963 proteasome (prosome, macropain) subunit, beta type, 11 A5LHX3 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 39 0 cytoplasm cytoplasm NA NA Cell.Organisms PSMB2 HGNC:9539 proteasome (prosome, macropain) subunit, beta type, 2 P49721 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 9344661 cytoplasm 38 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMB3 HGNC:9540 proteasome (prosome, macropain) subunit, beta type, 3 P49720 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9344661,9344661 cytoplasm 36 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMB4 HGNC:9541 proteasome (prosome, macropain) subunit, beta type, 4 P28070 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) cytoplasm 52 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms PSMB5 HGNC:9542 proteasome (prosome, macropain) subunit, beta type, 5 P28074 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 9382924,10692467,16263121 cytoplasm 56 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PSMB6 HGNC:9543 proteasome (prosome, macropain) subunit, beta type, 6 P28072 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) cytoplasm 38 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms PSMB7 HGNC:9544 proteasome (prosome, macropain) subunit, beta type, 7 Q99436 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10384092,11295498 cytoplasm 57 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PSMB8 HGNC:9545 proteasome (prosome, macropain) subunit, beta type, 8 P28062 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 10657252,10657252,10657252 cytoplasm 55 0 cytoplasm. endoplasmic reticulum. nucleus multiple Cell.Organisms Cell.Organisms NA PSMB9 HGNC:9546 proteasome (prosome, macropain) subunit, beta type, 9 P28065 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) 9367687 cytoplasm 45 0 nucleus nucleus NA NA NA PSMC1 HGNC:9547 proteasome (prosome, macropain) 26S subunit, ATPase, 1 P62191 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11734547,11734547 mitochondrion membrane 28 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PSMC2 HGNC:9548 proteasome (prosome, macropain) 26S subunit, ATPase, 2 P35998 Cytoplasm. Nucleus. Cytoplasm, P-body (By similarity). Note=Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11118327,11118327 mitochondrion 28 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMC3 HGNC:9549 proteasome (prosome, macropain) 26S subunit, ATPase, 3 P17980 Cytoplasm (Potential). Nucleus (Potential). Cytoplasm, P-body (By similarity). Note=Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Nucleus (GO:0005634) 2194290 mitochondrion membrane 26 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms PSMC3IP HGNC:17928 PSMC3 interacting protein Q9P2W1 Nucleus. Nucleus (GO:0005634) 11739747,10806355,9345291 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PSMC4 HGNC:9551 proteasome (prosome, macropain) 26S subunit, ATPase, 4 P43686 Cytoplasm. Nucleus. Nucleus (GO:0005634) 8419915 mitochondrion membrane 28 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMC5 HGNC:9552 proteasome (prosome, macropain) 26S subunit, ATPase, 5 P62195 Cytoplasm (Potential). Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10970867,14702340,10970867,14702340 mitochondrion membrane 30 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSMC6 HGNC:9553 proteasome (prosome, macropain) 26S subunit, ATPase, 6 P62333 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 12499840,8674546 nucleus 30 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms PSMD1 HGNC:9554 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Q99460 Cytoplasm (GO:0005737); Cytosol (GO:0005829); Nucleus (GO:0005634) ,16263121,15561729,17081983 cytoplasm 6 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PSMD10 HGNC:9555 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 O75832 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15910504,12174370,11779854,12174370,15910504 cytoplasm 22 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms PSMD11 HGNC:9556 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 O00231 Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 1317798,17081983 cytoplasm 39 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PSMD12 HGNC:9557 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 O00232 Cytoplasm (GO:0005737) 1317798 nucleus 32 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PSMD13 HGNC:9558 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Q9UNM6 Cytoplasm (GO:0005737) 10225435 cytoplasm 10 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PSMD14 HGNC:16889 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 O00487 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9374539,9374539 nucleus 21 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PSMD2 HGNC:9559 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Q13200 Cytoplasm (GO:0005737); Cytosol (GO:0005829) 7601280,15561729 plasma membrane 5 1 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PSMD3 HGNC:9560 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 O43242 Cytoplasm (GO:0005737); Peroxisome (GO:0005777) ,15561729 nucleus 37 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PSMD4 HGNC:9561 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 P55036 Cytoplasm (GO:0005737) 10505793,17623810 cytoplasm 91 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota PSMD5 HGNC:9563 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Q16401 Cytoplasm (GO:0005737) 1317798 nucleus 63 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota PSMD6 HGNC:9564 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Q15008 Peroxisome (GO:0005777) 15561729 nucleus 40 0 peroxisome peroxisome Eukaryota Eukaryota Eukaryota PSMD7 HGNC:9565 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 P51665 Nucleus (GO:0005634) 9520381 cytoplasm 15 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PSMD8 HGNC:9566 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 P48556 Cytoplasm (GO:0005737) nucleus 86 0 nucleus nucleus Eukaryota Eukaryota Eukaryota PSMD9 HGNC:9567 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 O00233 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11940657,9653651,11940657 cytoplasm 65 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms PSME1 HGNC:9568 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Q06323 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9287111,9287111 nucleus 20 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota PSME2 HGNC:9569 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Q9UL46 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730) 8663520,9840465,8663520,8663520,9840465 nucleus 12 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Euteleostomi Eukaryota PSME3 HGNC:9570 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) P61289 Nucleus. Cytoplasm (By similarity). Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9590240,16439211,9590240 nucleus 23 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota PSME4 HGNC:20635 proteasome (prosome, macropain) activator subunit 4 Q14997 Cytoplasm, cytosol (By similarity). Nucleus. Nucleus speckle (By similarity). Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2). Nucleus (GO:0005634) 12093752 nucleus 83 2 nucleus nucleus Bilateria Eukaryota Eukaryota PSMF1 HGNC:9571 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) Q92530 Nuclear membrane (GO:0005635); Endoplasmic reticulum (GO:0005783) 12374861,12374861 secreted 31 0 endoplasmic reticulum. nucleus membrane multiple Theria Eukaryota Eukaryota PSMG1 HGNC:3043 proteasome (prosome, macropain) assembly chaperone 1 O95456 Cytoplasm. Endoplasmic reticulum. Plasma membrane (GO:0005886) 9784380 nucleus 49 0 cytoplasm. endoplasmic reticulum multiple Deuterostomia Eukaryota Eumetazoa PSMG2 HGNC:24929 proteasome (prosome, macropain) assembly chaperone 2 Q969U7 Nucleus (By similarity). Nucleus (GO:0005634) 12147697 nucleus 85 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota PSMG3 HGNC:22420 proteasome (prosome, macropain) assembly chaperone 3 Q9BT73 secreted 34 0 secreted secreted Euteleostomi Eukaryota Eukaryota PSMG4 HGNC:21108 proteasome (prosome, macropain) assembly chaperone 4 Q5JS54 cytoplasm 9 0 cytoplasm cytoplasm Theria Eukaryota Holozoa PSORS1C1 HGNC:17202 psoriasis susceptibility 1 candidate 1 Q9UIG5 nucleus 28 0 nucleus nucleus Homininae Homininae NA PSORS1C2 HGNC:17199 psoriasis susceptibility 1 candidate 2 Q9UIG4 Secreted (Potential). secreted 12 0 secreted secreted Theria Theria NA PSPC1 HGNC:20320 paraspeckle component 1 Q8WXF1 Nucleus, nucleolus. Nucleus matrix (By similarity). Cytoplasm (By similarity). Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11790299,11790299,15635413,11790298 nucleus 56 0 nucleus nucleus Amniota Eukaryota Cell.Organisms PSPH HGNC:9577 phosphoserine phosphatase P78330 Cytoplasm (GO:0005737) 1965857 mitochondrion 38 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms PSPN HGNC:9579 persephin O60542 Secreted. Extracellular (GO:0005576) 9740802 secreted 100 0 secreted secreted Eutheria Euteleostomi Craniata PSRC1 HGNC:24472 proline/serine-rich coiled-coil 1 Q6PGN9 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase. Cytoplasm (GO:0005737) 12427559,10618717 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Mammalia Euteleostomi PSTK HGNC:28578 phosphoseryl-tRNA kinase Q8IV42 cytoplasm 31 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms PSTPIP1 HGNC:9580 proline-serine-threonine phosphatase interacting protein 1 O43586 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Cytoplasm, perinuclear region (By similarity). Cleavage furrow (By similarity). Note=Colocalized with the cortical actin cytoskeleton during interphase, lamellipodia and actin-rich cytokinetic cleavage furrow. Colocalized with WAS to filamentous structures within the cytoplasm. Colocalized with PTPN12 in the cytoplasm and the perinuclear region. Colocalized with CD2AP and WAS in the actin cytoskeleton. Colocalized with CD2, CD2AP and WAS at the site of T-cell:APC contact (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Intracellular vesicle (None) 9857189,9857189,16204241 cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota PSTPIP2 HGNC:9581 proline-serine-threonine phosphatase interacting protein 2 Q9H939 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737) 9804817 cytoplasm 10 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota PTAFR HGNC:9582 platelet-activating factor receptor P25105 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1312046,6325330 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa PTAR1 HGNC:30449 protein prenyltransferase alpha subunit repeat containing 1 Q7Z6K3 nucleus 39 0 nucleus nucleus Amniota Eukaryota Eukaryota PTBP1 HGNC:9583 polypyrimidine tract binding protein 1 P26599 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730);Nucleus (GO:0005634) 1641332,11781313,11781313,11602719,15039777,9166399,15635413/17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota PTBP2 HGNC:17662 polypyrimidine tract binding protein 2 Q9UKA9 Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 11694331,11790298 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota PTBP3 HGNC:10253 polypyrimidine tract binding protein 3 O95758 Nucleus (GO:0005634) nucleus 72 0 nucleus nucleus Bilateria Eukaryota Eukaryota PTCD1 HGNC:22198 pentatricopeptide repeat domain 1 O75127 Mitochondrion. Mitochondrion matrix (By similarity). mitochondrion 69 0 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota PTCD2 HGNC:25734 pentatricopeptide repeat domain 2 Q8WV60 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Amniota Bilateria Bilateria PTCD3 HGNC:24717 pentatricopeptide repeat domain 3 Q96EY7 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Bilateria Bilateria Eukaryota PTCH1 HGNC:9585 patched 1 Q13635 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8658145 plasma membrane 12 13 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota PTCH2 HGNC:9586 patched 2 Q9Y6C5 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10029063 plasma membrane 19 13 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms PTCHD1 HGNC:26392 patched domain containing 1 Q96NR3 Cell membrane; Multi-pass membrane protein. plasma membrane 100 14 plasma membrane plasma membrane Chordata Bilateria Eukaryota PTCHD2 HGNC:29251 patched domain containing 2 Q9P2K9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 7 13 plasma membrane plasma membrane Human Deuterostomia Cell.Organisms PTCHD3 HGNC:24776 patched domain containing 3 Q3KNS1 Membrane; Multi-pass membrane protein (Potential). Note=Localizes to the midpiece of the sperm tail. cytoplasm 20 8 cytoplasm cytoplasm Bilateria Bilateria NA PTCHD4 HGNC:21345 patched domain containing 4 Q6ZW05 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 39 14 plasma membrane plasma membrane NA NA Eukaryota PTCRA HGNC:21290 pre T-cell antigen receptor alpha Q6ISU1 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11927911 secreted 80 1 plasma membrane plasma membrane Euarchontoglires Eutheria Amniota PTDSS1 HGNC:9587 phosphatidylserine synthase 1 P48651 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Highly enriched in the mitochondria-associated membrane (MAM) (By similarity). Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10938271,17081983,17081983 endoplasmic reticulum membrane 97 9 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota PTDSS2 HGNC:15463 phosphatidylserine synthase 2 Q9BVG9 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Highly enriched in the mitochondria-associated membrane (MAM) (By similarity). Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10938271,17081983,17081983 endoplasmic reticulum membrane 90 9 cytoplasm. mitochondrion. nucleus multiple Eutheria Eukaryota Eukaryota PTEN HGNC:9588 phosphatase and tensin homolog P60484 Cytoplasm. Nucleus. Nucleus, PML body. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Apical membrane (GO:0016327) 9356475,16456542,10213484,10760291,17254974 cytoplasm 24 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PTER HGNC:9590 phosphotriesterase related Q96BW5 mitochondrion 29 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms PTF1A HGNC:23734 pancreas specific transcription factor, 1a Q7RTS3 Nucleus (By similarity). Cytoplasm (By similarity). Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9851981,1720355 nucleus 44 0 cytoplasm. nucleus multiple Human Bilateria Metazoa PTGDR HGNC:9591 prostaglandin D2 receptor (DP) Q13258 Cell membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12672054 plasma membrane 32 7 plasma membrane plasma membrane Eutheria Eutheria Eumetazoa PTGDR2 HGNC:4502 prostaglandin D2 receptor 2 Q9Y5Y4 Cell membrane; Multi-pass membrane protein (Potential). Note=Internalized receptors colocalized with RAB11A. Integral to membrane (GO:0016021) 10036181,9973380 plasma membrane 18 7 plasma membrane plasma membrane Mammalia Euteleostomi Eumetazoa PTGDS HGNC:9592 prostaglandin D2 synthase 21kDa (brain) P41222 Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 7692978,16199891,16188874,9065498 secreted 29 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Euteleostomi Euteleostomi Cell.Organisms PTGER1 HGNC:9593 prostaglandin E receptor 1 (subtype EP1), 42kDa P34995 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8253813 plasma membrane 100 7 plasma membrane plasma membrane Human Euteleostomi Euteleostomi PTGER2 HGNC:9594 prostaglandin E receptor 2 (subtype EP2), 53kDa P43116 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11093764 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria PTGER3 HGNC:9595 prostaglandin E receptor 3 (subtype EP3) P43115 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nuclear membrane (GO:0005635); Perinuclear region (GO:0048471) 10336471,10336471,10336471 plasma membrane 100 7 cytoplasm. nucleus membrane. plasma membrane multiple Euteleostomi Euteleostomi Bilateria PTGER4 HGNC:9596 prostaglandin E receptor 4 (subtype EP4) P35408 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11093764,11470276,11597569,11597569 plasma membrane 100 7 cytoplasm. plasma membrane multiple Chordata Chordata Eumetazoa PTGES HGNC:9599 prostaglandin E synthase O14684 Membrane; Multi-pass membrane protein. Microsome (GO:0005792); Integral to membrane (GO:0016021) 10377395,10760517,10377395 endoplasmic reticulum membrane 57 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Cell.Organisms PTGES2 HGNC:17822 prostaglandin E synthase 2 Q9H7Z7 Golgi apparatus membrane; Single-pass membrane protein. Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthetized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11866447,12050152,12050152 mitochondrion 18 2 cytoplasm. endoplasmic reticulum. golgi apparatus membrane. nucleus multiple Bilateria Eukaryota Eukaryota PTGES3 HGNC:16049 prostaglandin E synthase 3 (cytosolic) Q15185 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11809754,17081983,10207098,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PTGES3L HGNC:43943 prostaglandin E synthase 3 (cytosolic)-like E9PB15 cytoplasm 30 0 cytoplasm cytoplasm NA NA NA PTGFR HGNC:9600 prostaglandin F receptor (FP) P43088 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12519077 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa PTGFRN HGNC:9601 prostaglandin F2 receptor inhibitor Q9P2B2 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Golgi apparatus, trans- Golgi network membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 8804121,8804121,9643346,9643346 plasma membrane 13 0 endoplasmic reticulum. endosome. golgi apparatus multiple Tetrapoda Euteleostomi Craniata PTGIR HGNC:9602 prostaglandin I2 (prostacyclin) receptor (IP) P43119 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12488443,12446735,7512962,11502878 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa PTGIS HGNC:9603 prostaglandin I2 (prostacyclin) synthase Q16647 Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11339822,11339822,11339822 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms PTGR1 HGNC:18429 prostaglandin reductase 1 Q14914 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms PTGR2 HGNC:20149 prostaglandin reductase 2 Q8N8N7 Cytoplasm (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms PTGS1 HGNC:9604 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) P23219 Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783) 7864630 secreted 29 0 endoplasmic reticulum endoplasmic reticulum Chordata Opisthokonta Cell.Organisms PTGS2 HGNC:9605 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) P35354 Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11981837,11401839,10705655,11981837,11432874,9545330,11432874,11432874,11401839,9545330 secreted 38 0 cytoplasm. endoplasmic reticulum. nucleus multiple Chordata Opisthokonta Cell.Organisms PTH HGNC:9606 parathyroid hormone P01270 Secreted. Extracellular (GO:0005576) 12490859 secreted 100 0 secreted secreted Theria Euteleostomi Euteleostomi PTH1R HGNC:9608 parathyroid hormone 1 receptor Q03431 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8197183 plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Holozoa PTH2 HGNC:30828 parathyroid hormone 2 Q96A98 Secreted. Extracellular (GO:0005576) 11861531 secreted 100 0 secreted secreted Eutheria Eutheria Eutheria PTH2R HGNC:9609 parathyroid hormone 2 receptor P49190 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7797535 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Holozoa PTHLH HGNC:9607 parathyroid hormone-like hormone P12272 Cytoplasm. Nucleus. Secreted. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Extracellular (GO:0005576) 12359237,9391077,10066803,11456271,12359237,10066803,10803599,8396010 nucleus 65 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Euteleostomi PTK2 HGNC:9611 protein tyrosine kinase 2 Q05397 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Nucleus. Note=Constituent of focal adhesions. Detected at microtubules. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Axon (GO:0030424);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/10801330,15855171,15855171,15494733/17081983,17081983 plasma membrane 31 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms PTK2B HGNC:9612 protein tyrosine kinase 2 beta Q14289 Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Note=Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleoplasm (GO:0005654); Plasma membrane (GO:0005886); Focal adhesion (GO:0005925); Perinuclear region (GO:0048471) 11820787,17684059,11937718,17684059,11937718,12943720,17205062,17205062,12943720,12943720 plasma membrane 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms PTK6 HGNC:9617 protein tyrosine kinase 6 Q13882 Cytoplasm. Nucleus. Cell projection, ruffle. Membrane (By similarity). Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10913193,10913193 cytoplasm 35 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Cell.Organisms PTK7 HGNC:9618 protein tyrosine kinase 7 Q13308 Membrane; Single-pass type I membrane protein. Cell junction. Note=Co-localizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. Plasma membrane (GO:0005886) 7478540 plasma membrane 25 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms PTMA HGNC:9623 prothymosin, alpha P06454 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 7916742,2209614,10891508,7588773,2209614,10891508 nucleus 100 0 cytoplasm. nucleus multiple Amniota Amniota Primates PTMS HGNC:9629 parathymosin P20962 Nucleus (GO:0005634) 10854063 nucleus 20 0 nucleus nucleus Eutheria Eutheria Amniota PTN HGNC:9630 pleiotrophin P21246 Secreted. Extracellular (GO:0005576) 8567685 secreted 100 0 secreted secreted Amniota Euteleostomi Chordata PTOV1 HGNC:9632 prostate tumor overexpressed 1 Q86YD1 Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12598323,12598323,11313889,15713644 nucleus 67 0 cytoplasm. nucleus multiple Eutheria Bilateria Eumetazoa PTP4A1 HGNC:9634 protein tyrosine phosphatase type IVA, member 1 Q93096 Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Centrosome (GO:0005813); Cytoplasm (GO:0005737); Microtubule (GO:0005874); Perinuclear region (GO:0048471) 10747914,12235145,12235145,12235145,12235145,12235145 cytoplasm 16 0 cytoplasm. endoplasmic reticulum. endosome. nucleus multiple Bilateria Eukaryota Cell.Organisms PTP4A2 HGNC:9635 protein tyrosine phosphatase type IVA, member 2 Q12974 Cell membrane. Early endosome. Cytoplasm. Perinuclear region (GO:0048471); Nucleus (GO:0005634); Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11447212,11447212,10747914,11447212,10747914,11447212,10747914,10940933,10747914 cytoplasm 16 0 cytoplasm. endosome. nucleus multiple Human Eukaryota Cell.Organisms PTP4A3 HGNC:9636 protein tyrosine phosphatase type IVA, member 3 O75365 Cell membrane. Early endosome. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endosome (GO:0005768) 10747914,10747914,10747914,10747914 nucleus 16 0 cytoplasm. endosome. nucleus multiple Human Euteleostomi Cell.Organisms PTPDC1 HGNC:30184 protein tyrosine phosphatase domain containing 1 A2A3K4 nucleus 19 0 nucleus nucleus Chordata Eukaryota Cell.Organisms PTPLA HGNC:9639 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A B0YJ81 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota NA PTPLAD1 HGNC:24175 protein tyrosine phosphatase-like A domain containing 1 Q9P035 Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Integral to membrane (GO:0016021) 15598749,15561729 endoplasmic reticulum membrane 100 6 endoplasmic reticulum membrane. mitochondrion multiple Deuterostomia Bilateria Eukaryota PTPLAD2 HGNC:20920 protein tyrosine phosphatase-like A domain containing 2 Q5VWC8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Amniota Eukaryota PTPLB HGNC:9640 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b Q6Y1H2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15024066 endoplasmic reticulum membrane 100 5 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Eukaryota PTPMT1 HGNC:26965 protein tyrosine phosphatase, mitochondrial 1 Q8WUK0 Mitochondrion inner membrane (By similarity). Note=Associated with the inner membrane (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms PTPN1 HGNC:9642 protein tyrosine phosphatase, non-receptor type 1 P18031 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interacts with EPHA3 at the cell membrane. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 7935344,11106648,2546149,11106648 cytoplasm 26 1 cytoplasm. endoplasmic reticulum multiple Euteleostomi Bilateria Eukaryota PTPN11 HGNC:9644 protein tyrosine phosphatase, non-receptor type 11 Q06124 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10940933,10940933 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PTPN12 HGNC:9645 protein tyrosine phosphatase, non-receptor type 12 Q05209 Cytoplasm. Cell projection, podosome (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8887669,17081983,17081983 cytoplasm 26 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Eukaryota PTPN13 HGNC:9646 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) Q12923 Cytoplasm, cytoskeleton (By similarity). Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Early endosome (GO:0005769) 10544233,16498403,12095257,16498403 cytoplasm 25 0 cytoplasm. endosome. nucleus multiple Mammalia Deuterostomia Eukaryota PTPN14 HGNC:9647 protein tyrosine phosphatase, non-receptor type 14 Q15678 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytoskeleton (GO:0005856) 10934049,10934049,17081983,10400706 cytoplasm 25 2 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota PTPN18 HGNC:9649 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) Q99952 Nucleus (By similarity). Cytoplasm (By similarity). cytoplasm 33 0 cytoplasm cytoplasm Euarchontoglires Chordata Eukaryota PTPN2 HGNC:9650 protein tyrosine phosphatase, non-receptor type 2 P17706 Cytoplasm. Isoform PTPB: Endoplasmic reticulum. Isoform PTPA: Nucleus. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 9261175,7593185,9261175,7593185,15696169/9261175,7593185 cytoplasm 24 1 cytoplasm. endoplasmic reticulum. nucleus multiple Chordata Chordata Eukaryota PTPN20A HGNC:23422 protein tyrosine phosphatase, non-receptor type 20A Q4JDL3 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Microtubule (GO:0005874); Mitochondrial membrane (GO:0005740); Actin cytoskeleton (GO:0015629) 15790311,15790311,15790311,15790311,15790311,15790311,15790311 cytoplasm 27 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion membrane. nucleus multiple Tetrapoda Opisthokonta Eukaryota PTPN20B HGNC:23423 protein tyrosine phosphatase, non-receptor type 20B Q4JDL3 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments. cytoplasm 27 0 cytoplasm. nucleus multiple Tetrapoda Opisthokonta NA PTPN21 HGNC:9651 protein tyrosine phosphatase, non-receptor type 21 Q16825 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10585123,15143158 cytoplasm 25 2 cytoplasm. mitochondrion multiple Deuterostomia Bilateria Eukaryota PTPN22 HGNC:9652 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Q9Y2R2 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471);Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10068674,10068674/10940933,10940933,10940933 cytoplasm 65 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota PTPN23 HGNC:14406 protein tyrosine phosphatase, non-receptor type 23 Q9H3S7 Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11095967,17081983 cytoplasm 19 0 cytoplasm. endosome. nucleus multiple Theria Opisthokonta Eukaryota PTPN3 HGNC:9655 protein tyrosine phosphatase, non-receptor type 3 P26045 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10940933,10940933 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms PTPN4 HGNC:9656 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) P29074 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8910369,8917530,8910369 cytoplasm 29 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota PTPN5 HGNC:9657 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) P54829 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cytoplasm (GO:0005737) 9272866 cytoplasm 41 2 cytoplasm cytoplasm Theria Euteleostomi Eukaryota PTPN6 HGNC:9658 protein tyrosine phosphatase, non-receptor type 6 P29350 Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10940933,15598749 cytoplasm 49 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria NA PTPN7 HGNC:9659 protein tyrosine phosphatase, non-receptor type 7 P35236 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10940933,10940933 cytoplasm 100 0 cytoplasm cytoplasm Amniota Amniota Cell.Organisms PTPN9 HGNC:9661 protein tyrosine phosphatase, non-receptor type 9 P43378 Cytoplasm (Probable). Cytoplasm (GO:0005737) 1557404 cytoplasm 25 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota PTPRA HGNC:9664 protein tyrosine phosphatase, receptor type, A P18433 Membrane; Single-pass type I membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886) 17081983,17081983/2169617,9183007 cytoplasm 23 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms PTPRB HGNC:9665 protein tyrosine phosphatase, receptor type, B P23467 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 2170109,17081983 cytoplasm 27 1 nucleus. plasma membrane multiple Bilateria Bilateria Eukaryota PTPRC HGNC:9666 protein tyrosine phosphatase, receptor type, C P08575 Membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 2956090,2845400,15598749 cytoplasm 27 1 mitochondrion. plasma membrane multiple Euteleostomi Eukaryota NA PTPRCAP HGNC:9667 protein tyrosine phosphatase, receptor type, C-associated protein Q14761 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) ,15598749 secreted 78 1 plasma membrane plasma membrane Theria Theria Mammalia PTPRD HGNC:9668 protein tyrosine phosphatase, receptor type, D P23468 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7896816 cytoplasm 28 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms PTPRE HGNC:9669 protein tyrosine phosphatase, receptor type, E P23469 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10490839,10490839,8618876,12193229,10980613,12193229 cytoplasm 27 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms PTPRF HGNC:9670 protein tyrosine phosphatase, receptor type, F P10586 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 2972792,8524829,8917069 cytoplasm 28 1 plasma membrane. secreted multiple Bilateria Eukaryota Cell.Organisms PTPRG HGNC:9671 protein tyrosine phosphatase, receptor type, G P23470 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 8382771 cytoplasm 27 2 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms PTPRH HGNC:9672 protein tyrosine phosphatase, receptor type, H Q9HD43 Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Plasma membrane (GO:0005886) 8294459,11435690 cytoplasm 24 1 cytoplasm. plasma membrane multiple Theria Euteleostomi Cell.Organisms PTPRJ HGNC:9673 protein tyrosine phosphatase, receptor type, J Q12913 Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane (By similarity). Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses. Plasma membrane (GO:0005886) 10648410,7937872 cytoplasm 24 1 plasma membrane plasma membrane Euteleostomi Eukaryota Eukaryota PTPRK HGNC:9674 protein tyrosine phosphatase, receptor type, K Q15262 Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 8663237,14718574 cytoplasm 29 1 plasma membrane. secreted multiple Deuterostomia Deuterostomia Eukaryota PTPRM HGNC:9675 protein tyrosine phosphatase, receptor type, M P28827 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 7961788,1655529 cytoplasm 30 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Eukaryota PTPRN HGNC:9676 protein tyrosine phosphatase, receptor type, N Q16849 Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules. Plasma membrane (GO:0005886) 11079748,8024693 cytoplasm 27 1 plasma membrane plasma membrane Bilateria Bilateria Eukaryota PTPRN2 HGNC:9677 protein tyrosine phosphatase, receptor type, N polypeptide 2 Q92932 Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 8798755 cytoplasm 29 1 plasma membrane plasma membrane Bilateria Bilateria Eukaryota PTPRO HGNC:9678 protein tyrosine phosphatase, receptor type, O Q16827 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 7665166 cytoplasm 29 2 cytoplasm cytoplasm Euteleostomi Opisthokonta Cell.Organisms PTPRQ HGNC:9679 protein tyrosine phosphatase, receptor type, Q Q9UMZ3 Membrane; Single-pass type I membrane protein. cytoplasm 26 1 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms PTPRR HGNC:9680 protein tyrosine phosphatase, receptor type, R Q15256 Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cytoplasm, perinuclear region. Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm. Integral to membrane (GO:0016021) 7836467 cytoplasm 44 1 cytoplasm. plasma membrane multiple Euteleostomi Deuterostomia Eukaryota PTPRS HGNC:9681 protein tyrosine phosphatase, receptor type, S Q13332 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8524829 cytoplasm 27 1 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms PTPRT HGNC:9682 protein tyrosine phosphatase, receptor type, T O14522 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9602027,11423001 cytoplasm 28 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Eukaryota PTPRU HGNC:9683 protein tyrosine phosphatase, receptor type, U Q92729 Cell junction. Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8700514 cytoplasm 27 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Eukaryota PTPRZ1 HGNC:9685 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 P23471 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986) 8387522,17681947 cytoplasm 28 1 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms PTRF HGNC:9688 polymerase I and transcript release factor Q6NZI2 Membrane, caveola. Cell membrane. Microsome. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co- localizes with CAV1 in lipid rafts in adipocytes. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9582279,17081983,17081983/17081983,17081983 cytoplasm 28 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Craniata PTRH1 HGNC:27039 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) Q86Y79 mitochondrion 18 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms PTRH2 HGNC:24265 peptidyl-tRNA hydrolase 2 Q9Y3E5 Mitochondrion. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15006356,15006356,15598749 mitochondrion 100 1 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms PTRHD1 HGNC:33782 peptidyl-tRNA hydrolase domain containing 1 Q6GMV3 cytoplasm 46 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota PTS HGNC:9689 6-pyruvoyltetrahydropterin synthase Q03393 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14729142,14729142 cytoplasm 38 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms PTTG1 HGNC:9690 pituitary tumor-transforming 1 O95997 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9811450,9811450 nucleus 60 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Euteleostomi PTTG1IP HGNC:13524 pituitary tumor-transforming 1 interacting protein P53801 Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10781616,10781616 plasma membrane 42 1 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eumetazoa PTTG2 HGNC:9691 pituitary tumor-transforming 2 Q9NZH5 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 61 0 nucleus nucleus NA NA Euteleostomi PTX3 HGNC:9692 pentraxin 3, long P26022 Secreted. Extracellular (GO:0005576) 12611905 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms PTX4 HGNC:14171 pentraxin 4, long Q96A99 Secreted (Potential). secreted 21 0 secreted secreted NA NA Cell.Organisms PUF60 HGNC:17042 poly-U binding splicing factor 60KDa Q9UHX1 Nucleus. Note=Colocalizes partially with TROVE2. Nucleus (GO:0005634) 10668799,19059367 nucleus 100 0 nucleus nucleus Bilateria Eukaryota NA PUM1 HGNC:14957 pumilio RNA-binding family member 1 Q14671 Cytoplasm (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 44 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PUM2 HGNC:14958 pumilio RNA-binding family member 2 Q8TB72 Cytoplasm (Probable). Cytoplasmic granule (By similarity). Cytoplasm, perinuclear region. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Co-localizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12511597,17081983,12511597 cytoplasm 45 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota PURA HGNC:9701 purine-rich element binding protein A Q00577 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11032728,19059367,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota PURB HGNC:9702 purine-rich element binding protein B Q96QR8 Nucleus. Nucleus (GO:0005634) 12933792 nucleus 100 0 nucleus nucleus Human Euteleostomi Eukaryota PURG HGNC:17930 purine-rich element binding protein G Q9UJV8 Nucleus (By similarity). Nucleus (GO:0005634) 12034829 nucleus 58 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota PUS1 HGNC:15508 pseudouridylate synthase 1 Q9Y606 Isoform 1: Mitochondrion. Isoform 2: Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15772074,15772074,15772074 mitochondrion 23 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms PUS10 HGNC:26505 pseudouridylate synthase 10 Q3MIT2 nucleus 35 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PUS3 HGNC:25461 pseudouridylate synthase 3 Q9BZE2 Nucleus (Potential). nucleus 35 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PUS7 HGNC:26033 pseudouridylate synthase 7 (putative) Q96PZ0 nucleus 28 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PUS7L HGNC:25276 pseudouridylate synthase 7 homolog (S. cerevisiae)-like Q9H0K6 nucleus 16 0 nucleus nucleus Eutheria Eukaryota Cell.Organisms PUSL1 HGNC:26914 pseudouridylate synthase-like 1 Q8N0Z8 nucleus 13 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms PVALB HGNC:9704 parvalbumin P20472 Cytoplasm (GO:0005737) 7790883 vacuole 20 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Craniata PVR HGNC:9705 poliovirus receptor P15151 Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Beta: Secreted. Isoform Gamma: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10618374,2538245,11983699,2170108,10618374,11437656,2170108 plasma membrane 46 1 plasma membrane. secreted multiple Catarrhini Eutheria Bilateria PVRIG HGNC:32190 poliovirus receptor related immunoglobulin domain containing Q6DKI7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 61 3 n/a n/a Homininae Eutheria Boreoeutheria PVRL1 HGNC:9706 poliovirus receptor-related 1 (herpesvirus entry mediator C) Q15223 Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Gamma: Secreted. Cell junction (GO:0030054) 12072519,12885915 plasma membrane 95 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Metazoa PVRL2 HGNC:9707 poliovirus receptor-related 2 (herpesvirus entry mediator B) Q92692 Cell membrane; Single-pass type I membrane protein. Nucleus (GO:0005634);Plasma membrane (GO:0005886) 17081983/9845526 plasma membrane 100 1 nucleus. plasma membrane multiple Euteleostomi Euteleostomi Bilateria PVRL3 HGNC:17664 poliovirus receptor-related 3 Q9NQS3 Cell membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10744716 plasma membrane 19 2 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa PVRL4 HGNC:19688 poliovirus receptor-related 4 Q96NY8 Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, adherens junction. Processed poliovirus receptor-related protein 4: Secreted. Note=The secreted form is found in breast tumor patients. Plasma membrane (GO:0005886) 11544254 plasma membrane 16 1 plasma membrane. secreted multiple Mammalia Euteleostomi Bilateria PWP1 HGNC:17015 PWP1 homolog (S. cerevisiae) Q13610 Nucleus. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Nucleolus (GO:0005730) 7828893,11850830,15561729,11850830,11790298 nucleus 100 0 endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Cell.Organisms PWP2 HGNC:9711 PWP2 periodic tryptophan protein homolog (yeast) Q15269 Nucleus, nucleolus. Nucleolus (GO:0005730); Ribosome (GO:0005840) 15635413,11790298,15561729 nucleus 100 0 nucleus nucleus NA NA Cell.Organisms PWWP2A HGNC:29406 PWWP domain containing 2A Q96N64 nucleus 17 0 nucleus nucleus Chordata Chordata Eukaryota PWWP2B HGNC:25150 PWWP domain containing 2B Q6NUJ5 nucleus 31 0 nucleus nucleus Euarchontoglires Deuterostomia Eukaryota PXDC1 HGNC:21361 PX domain containing 1 Q5TGL8 nucleus 53 0 nucleus nucleus Euteleostomi Euteleostomi Chordata PXDN HGNC:14966 peroxidasin homolog (Drosophila) Q92626 Secreted, extracellular space, extracellular matrix. Note=Enriched in the peritubular space of fibrotic kidneys. secreted 100 0 secreted secreted Bilateria Bilateria Cell.Organisms PXDNL HGNC:26359 peroxidasin homolog (Drosophila)-like A1KZ92 Secreted (Potential). Isoform PMR1: Cytoplasm. Note=Associates with polysomes. Nucleus (GO:0005634) secreted 52 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms PXK HGNC:23326 PX domain containing serine/threonine kinase Q7Z7A4 Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell. cytoplasm 85 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota PXMP2 HGNC:9716 peroxisomal membrane protein 2, 22kDa Q9NR77 Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 11590176 peroxisome membrane 100 5 peroxisome. peroxisome membrane multiple Bilateria Cell.Organisms Eukaryota PXMP4 HGNC:15920 peroxisomal membrane protein 4, 24kDa Q9Y6I8 Peroxisome membrane; Multi-pass membrane protein (By similarity). Peroxisome (GO:0005777) 10366717 peroxisome membrane 78 4 peroxisome peroxisome Deuterostomia Eukaryota Eukaryota PXN HGNC:9718 paxillin P49023 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex (By similarity). Note=Colocalizes with integrins at the cell periphery (By similarity). Focal adhesion (GO:0005925); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular matrix (GO:0005578); Cytosol (GO:0005829); Membrane fraction (GO:0005624); Soluble fraction (GO:0005625) 12861019,12861019,10749932,12861019,10749932,12861019,17082770,9114003,9114003,10749932 cytoplasm 23 0 cytoplasm. golgi apparatus. secreted multiple Opisthokonta Eukaryota Eukaryota PXT1 HGNC:18312 peroxisomal, testis specific 1 Q8NFP0 Peroxisome (By similarity). Peroxisome (GO:0005777) peroxisome 51 1 peroxisome peroxisome Homininae Euarchontoglires Boreoeutheria PXYLP1 HGNC:26303 2-phosphoxylose phosphatase 1 Q8TE99 Secreted (Potential). secreted 13 0 secreted secreted Chordata Eukaryota Cell.Organisms PYCARD HGNC:16608 PYD and CARD domain containing Q9ULZ3 Cytoplasm. Endoplasmic reticulum. Mitochondrion. Nucleus. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria. Localized primarily to the nucleus in resting monocytes/macrophages and rapidly redistributed to the cytoplasm upon pathogen infection. Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (By similarity). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 12019269,11103776,17339483,17339483 cytoplasm 56 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Euteleostomi PYCR1 HGNC:9721 pyrroline-5-carboxylate reductase 1 P32322 Mitochondrion. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Microsome (GO:0005792) 8880459,8880459,15598749,8880459,8880459 mitochondrion 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms PYCR2 HGNC:30262 pyrroline-5-carboxylate reductase family, member 2 Q96C36 Cytoplasm. Mitochondrion (GO:0005739) 15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms PYCRL HGNC:25846 pyrroline-5-carboxylate reductase-like Q53H96 cytoplasm 35 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms PYDC1 HGNC:30261 PYD (pyrin domain) containing 1 Q8WXC3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Catarrhini Euteleostomi PYDC2 HGNC:33512 pyrin domain containing 2 Q56P42 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 17339483,17178784,17339483,17178784,17339483 cytoplasm 60 0 cytoplasm. nucleus multiple NA NA Eutheria PYGB HGNC:9723 phosphorylase, glycogen; brain P11216 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7775103,9792273,17081983 mitochondrion 35 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms PYGL HGNC:9725 phosphorylase, glycogen, liver P06737 mitochondrion 34 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms PYGM HGNC:9726 phosphorylase, glycogen, muscle P11217 Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 7744850,16188874 cytoplasm 35 0 endoplasmic reticulum. secreted multiple Eukaryota Cell.Organisms Cell.Organisms PYGO1 HGNC:30256 pygopus family PHD finger 1 Q9Y3Y4 Nucleus (Probable). Nucleus (GO:0005634) 11955446,11988739 nucleus 27 0 nucleus nucleus Tetrapoda Euteleostomi Holozoa PYGO2 HGNC:30257 pygopus family PHD finger 2 Q9BRQ0 Nucleus (Probable). Nucleus (GO:0005634) 11955446,11988739 nucleus 23 0 nucleus nucleus Human Human Holozoa PYHIN1 HGNC:28894 pyrin and HIN domain family, member 1 Q6K0P9 Isoform 1: Nucleus, nucleoplasm. Isoform 3: Nucleus, nucleoplasm. Isoform 5: Nucleus. Nucleus speckle. Nucleus (GO:0005634) 15122330 nucleus 100 0 nucleus nucleus Human Human Eutheria PYROXD1 HGNC:26162 pyridine nucleotide-disulphide oxidoreductase domain 1 Q8WU10 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms PYROXD2 HGNC:23517 pyridine nucleotide-disulphide oxidoreductase domain 2 Q8N2H3 cytoplasm 21 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms PYURF HGNC:44317 PIGY upstream reading frame Q96I23 Mitochondrion (Potential). mitochondrion 17 0 mitochondrion mitochondrion NA NA Cell.Organisms PYY HGNC:9748 peptide YY P10082 Secreted. Secretory granule (GO:0030141); Extracellular (GO:0005576) 3517149,7493937 secreted 100 0 secreted secreted Theria Euteleostomi Craniata PZP HGNC:9750 pregnancy-zone protein P20742 Secreted. Extracellular (GO:0005576) 11811950,8662763 secreted 100 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms QARS HGNC:9751 glutaminyl-tRNA synthetase P47897 Cytoplasm. Cytoplasm (GO:0005737); Cytosol (GO:0005829) 10791971,15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms QDPR HGNC:9752 quinoid dihydropteridine reductase P09417 Extracellular (GO:0005576) 14718574 cytoplasm 90 0 secreted secreted Bilateria Eukaryota Cell.Organisms QKI HGNC:21100 QKI, KH domain containing, RNA binding Q96PU8 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm (GO:0005737) 8987822 nucleus 46 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota QPCT HGNC:9753 glutaminyl-peptide cyclotransferase Q16769 Secreted. Extracellular (GO:0005576) 12196024 secreted 100 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms QPCTL HGNC:25952 glutaminyl-peptide cyclotransferase-like Q9NXS2 Golgi apparatus membrane; Single-pass type I membrane protein. golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Bilateria Cell.Organisms Eukaryota QPRT HGNC:9755 quinolinate phosphoribosyltransferase Q15274 mitochondrion 21 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms QRFP HGNC:29982 pyroglutamylated RFamide peptide P83859 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Tetrapoda Tetrapoda Tetrapoda QRFPR HGNC:15565 pyroglutamylated RFamide peptide receptor Q96P65 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11574155 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa QRICH1 HGNC:24713 glutamine-rich 1 Q2TAL8 nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa QRICH2 HGNC:25326 glutamine rich 2 Q9H0J4 secreted 18 0 secreted secreted Mammalia Chordata Cell.Organisms QRSL1 HGNC:21020 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 Q9H0R6 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms QSER1 HGNC:26154 glutamine and serine rich 1 Q2KHR3 nucleus 90 0 nucleus nucleus Tetrapoda Euteleostomi Chordata QSOX1 HGNC:9756 quiescin Q6 sulfhydryl oxidase 1 O00391 Isoform 1: Golgi apparatus membrane; Single- pass membrane protein. Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells. Extracellular matrix (GO:0005578); Secretory vesicle (None); Extracellular (GO:0005576); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 10708601,12176051,10708601,12176051,12176051,12176051 secreted 68 1 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. secreted multiple Bilateria Bilateria Cell.Organisms QSOX2 HGNC:30249 quiescin Q6 sulfhydryl oxidase 2 Q6ZRP7 Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein (Potential). Nucleus membrane; Single-pass membrane protein (Potential). Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14633699,14633699,14633699 secreted 28 1 cytoplasm. nucleus. plasma membrane. secreted multiple Tetrapoda Euteleostomi NA QTRT1 HGNC:23797 queuine tRNA-ribosyltransferase 1 Q9BXR0 Cytoplasm (By similarity). Mitochondrion (By similarity). Nucleus (By similarity). Note=Weakly associates with mitochondria, possibly via QTRTD1 (By similarity). cytoplasm 14 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms QTRTD1 HGNC:25771 queuine tRNA-ribosyltransferase domain containing 1 Q9H974 Cytoplasm (By similarity). Mitochondrion (By similarity). Note=May associate with the mitochondrion outer membrane (By similarity). cytoplasm 13 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms R3HCC1 HGNC:27329 R3H domain and coiled-coil containing 1 Q9Y3T6 mitochondrion 24 0 mitochondrion mitochondrion Amniota Euteleostomi Eukaryota R3HCC1L HGNC:23512 R3H domain and coiled-coil containing 1-like Q7Z5L2 nucleus 78 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota R3HDM1 HGNC:9757 R3H domain containing 1 Q15032 cytoplasm 44 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota R3HDM2 HGNC:29167 R3H domain containing 2 Q9Y2K5 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 35 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota R3HDM4 HGNC:28270 R3H domain containing 4 Q96D70 Nucleus (Potential). nucleus 84 0 nucleus nucleus Theria Deuterostomia Holozoa R3HDML HGNC:16249 R3H domain containing-like Q9H3Y0 Secreted (Potential). Extracellular (GO:0005576) secreted 47 0 secreted secreted Mammalia Eukaryota Cell.Organisms RAB10 HGNC:9759 RAB10, member RAS oncogene family P61026 Cytoplasmic vesicle membrane; Lipid-anchor (Probable); Cytoplasmic side (Probable). Golgi apparatus, trans- Golgi network membrane (By similarity). Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane (By similarity). Cell projection, cilium. Endoplasmic reticulum membrane. Note=Associates with SLC2A4/GLUT4 storage vesicles. Localizes to the base of the cilium. Transiently associates with phagosomes (By similarity). According to PubMed:23263280 localizes to the endoplasmic reticulum at domains of new tubule growth. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Golgi vesicle (GO:0005798); Mitochondrion (GO:0005739) 7688123,7688123,7688123,17215244,19008234,15598749 cytoplasm 36 0 cytoplasm. endosome. golgi apparatus. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAB11A HGNC:9760 RAB11A, member RAS oncogene family P62491 Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis. Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 1711847,12540381,15598749 cytoplasm 25 0 golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms RAB11B HGNC:9761 RAB11B, member RAS oncogene family Q15907 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 10942597,10942597,10942597 cytoplasm 27 0 golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAB11FIP1 HGNC:30265 RAB11 family interacting protein 1 (class I) Q6WKZ4 Recycling endosome. Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytosol (GO:0005829) 17081983,17081983/11786538,15280022,11786538,15280022 cytoplasm 17 0 cytoplasm. endosome. nucleus multiple Euteleostomi Euteleostomi Eukaryota RAB11FIP2 HGNC:29152 RAB11 family interacting protein 2 (class I) Q7L804 Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Endosome (GO:0005768); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11994279,15304524,11994279,15304524,15304524 plasma membrane 18 0 cytoplasm. endosome multiple Deuterostomia Deuterostomia Eukaryota RAB11FIP3 HGNC:17224 RAB11 family interacting protein 3 (class II) O75154 Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody. Cytoplasm (GO:0005737); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 11481332,10593962,11481332,11481332,11481332,15158446 plasma membrane 34 0 cytoplasm. endosome. golgi apparatus multiple Deuterostomia Deuterostomia Holozoa RAB11FIP4 HGNC:30267 RAB11 family interacting protein 4 (class II) Q86YS3 Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis. Endosome (GO:0005768); Cytoplasmic vesicle (GO:0016023) 12470645,12470645 nucleus 18 0 endosome endosome Amniota Bilateria Holozoa RAB11FIP5 HGNC:24845 RAB11 family interacting protein 5 (class I) Q9BXF6 Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Mitochondrion (GO:0005739); Microsome (GO:0005792); Endosome (GO:0005768); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12684040,11278501,12684040,12684040,11163216,11163216,11495908,17081983,17081983 cytoplasm 36 0 cytoplasm. endosome. mitochondrion. nucleus multiple Tetrapoda Euteleostomi Opisthokonta RAB12 HGNC:31332 RAB12, member RAS oncogene family Q6IQ22 Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Lysosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus membrane (By similarity). cytoplasm 26 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms RAB13 HGNC:9762 RAB13, member RAS oncogene family P51153 Cell junction, tight junction. Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 8294494,9712853 cytoplasm 33 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms RAB14 HGNC:16524 RAB14, member RAS oncogene family P61106 Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans- Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis. Integral to membrane (GO:0016021); Golgi apparatus (GO:0005794); Early endosome (GO:0005769); Mitochondrion (GO:0005739) 11149929,16962593,16962593,15598749 cytoplasm 29 0 endosome. golgi apparatus. mitochondrion multiple Bilateria Eukaryota Cell.Organisms RAB15 HGNC:20150 RAB15, member RAS oncogene family P59190 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Endosome (GO:0005768) 10837464,10428799 cytoplasm 29 0 endosome endosome Human Deuterostomia Cell.Organisms RAB17 HGNC:16523 RAB17, member RAS oncogene family Q9H0T7 Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cell projection, dendrite (By similarity). Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine (By similarity). Endosome (GO:0005768); Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 9624171,9624171,9624171 cytoplasm 21 0 endosome endosome Amniota Euteleostomi Cell.Organisms RAB18 HGNC:14244 RAB18, member RAS oncogene family Q9NP72 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886) 7706395 cytoplasm 24 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RAB19 HGNC:19982 RAB19, member RAS oncogene family A4D1S5 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 31 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAB1A HGNC:9758 RAB1A, member RAS oncogene family P62820 Golgi apparatus. Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10903204,10903204,16902405 vacuole 30 0 endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms RAB1B HGNC:18370 RAB1B, member RAS oncogene family Q9H0U4 Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). Cytoplasmic vesicle (GO:0016023); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 12051767,10493955,7592724,1918138,10493955,11306556,1918138,15598749,15561729 cytoplasm 29 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms RAB20 HGNC:18260 RAB20, member RAS oncogene family Q9NX57 Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis. Plasma membrane (GO:0005886); Endosome (GO:0005768) 7706395,7706395 cytoplasm 19 0 endosome. golgi apparatus multiple Euteleostomi Deuterostomia Cell.Organisms RAB21 HGNC:18263 RAB21, member RAS oncogene family Q9UL25 Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10887961,10887961,15598749 cytoplasm 19 0 cytoplasm. endoplasmic reticulum. mitochondrion multiple Bilateria Eukaryota Cell.Organisms RAB22A HGNC:9764 RAB22A, member RAS oncogene family Q9UL26 Endosome membrane; Lipid-anchor (By similarity). Cell membrane; Lipid-anchor (By similarity). Early endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Endosome (GO:0005768); Golgi apparatus (GO:0005794) 11870209,11870209 vacuole 25 0 endosome. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms RAB23 HGNC:14263 RAB23, member RAS oncogene family Q9ULC3 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cell membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane (By similarity). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Plasma membrane (GO:0005886); Endosome (GO:0005768) 14617350,14617350 vacuole 24 0 cytoplasm. endosome multiple Deuterostomia Eukaryota Cell.Organisms RAB24 HGNC:9765 RAB24, member RAS oncogene family Q969Q5 Cytoplasm, cytosol. Membrane; Lipid-anchor (By similarity). Note=Only about 20-25% is recovered in the particulate fraction. Late endosome (GO:0005770); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 8126105,10660536,8126105,10660536,8126105,10660536,12323076 vacuole 21 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus multiple Euteleostomi Eukaryota Cell.Organisms RAB25 HGNC:18238 RAB25, member RAS oncogene family P57735 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cell projection, pseudopodium membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. Golgi apparatus (GO:0005794) 9389793 cytoplasm 25 0 golgi apparatus golgi apparatus Theria Euteleostomi Cell.Organisms RAB26 HGNC:14259 RAB26, member RAS oncogene family Q9ULW5 Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side (Probable). Note=Not localized at the plasma membrane (By similarity). Inhibition of S- geranylgeranyl cysteine formation abolishes membrane location. Secretory granule (GO:0030141) 10857477 cytoplasm 63 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAB27A HGNC:9766 RAB27A, member RAS oncogene family P51159 Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. Plasma membrane (GO:0005886); Cytosol (GO:0005829) 9066979,7592656,12122117,2507536 cytoplasm 32 0 cytoplasm. endosome. lysosome. melanosome multiple Deuterostomia Bilateria Cell.Organisms RAB27B HGNC:9767 RAB27B, member RAS oncogene family O00194 Membrane; Lipid-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Zymogen granule (GO:0042588) 9066979,1445946,9066979,1445946,16278343 cytoplasm 27 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms RAB28 HGNC:9768 RAB28, member RAS oncogene family P51157 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). vacuole 22 0 vacuole vacuole Deuterostomia Eukaryota Cell.Organisms RAB2A HGNC:9763 RAB2A, member RAS oncogene family P61019 Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor (Potential). Golgi apparatus membrane; Lipid-anchor (Potential). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 12376746,12376746,10996854,10996854,15598749,15561729 cytoplasm 34 0 cytoplasm. endoplasmic reticulum. golgi apparatus. melanosome. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms RAB2B HGNC:20246 RAB2B, member RAS oncogene family Q8WUD1 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Endoplasmic reticulum membrane (Potential). Golgi apparatus membrane (Potential). Golgi apparatus (GO:0005794) cytoplasm 34 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RAB30 HGNC:9770 RAB30, member RAS oncogene family Q15771 Membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans-Golgi network. Cytoplasm. Golgi apparatus. Golgi apparatus (GO:0005794) 9792283 cytoplasm 28 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Cell.Organisms RAB31 HGNC:9771 RAB31, member RAS oncogene family Q13636 Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side (Probable). Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11784320,11784320,17081983,17081983 vacuole 27 0 cytoplasm. endosome. golgi apparatus. mitochondrion. nucleus multiple Theria Deuterostomia Cell.Organisms RAB32 HGNC:9772 RAB32, member RAS oncogene family Q13637 Mitochondrion. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 12186851,11784320 cytoplasm 17 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms RAB33A HGNC:9773 RAB33A, member RAS oncogene family Q14088 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9712825,9712825 vacuole 24 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms RAB33B HGNC:16075 RAB33B, member RAS oncogene family Q9H082 Golgi apparatus membrane; Lipid-anchor (By similarity). Golgi apparatus, cis-Golgi network. Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 9512502,15598749 cytoplasm 20 0 golgi apparatus. mitochondrion multiple Deuterostomia Bilateria Cell.Organisms RAB34 HGNC:16519 RAB34, member RAS oncogene family P0DI83 Nucleus. Nucleus, nucleolus. Note=Colocalizes with rDNA clusters. Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytosol (GO:0005829) 12446704,12446704,12446704,12475955,12684051,15561729 nucleus 100 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Deuterostomia Bilateria Cell.Organisms RAB35 HGNC:9774 RAB35, member RAS oncogene family Q15286 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Note=Present on sorting endosomes and endosomal tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. cytoplasm 25 0 endosome. melanosome multiple Bilateria Eukaryota Cell.Organisms RAB36 HGNC:9775 RAB36, member RAS oncogene family O95755 Golgi apparatus membrane; Lipid-anchor. Golgi apparatus (GO:0005794) 9920784 cytoplasm 18 0 golgi apparatus golgi apparatus Deuterostomia Bilateria Cell.Organisms RAB37 HGNC:30268 RAB37, member RAS oncogene family Q96AX2 Cytoplasmic vesicle. Note=Secretory granules (By similarity). Secretory granule (GO:0030141) 10722846 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAB38 HGNC:9776 RAB38, member RAS oncogene family P57729 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11337364,11337364,11337364 cytoplasm 19 0 cytoplasm. endoplasmic reticulum. golgi apparatus. melanosome multiple Euteleostomi Eukaryota Cell.Organisms RAB39A HGNC:16521 RAB39A, member RAS oncogene family Q14964 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. cytoplasm 26 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAB39B HGNC:16499 RAB39B, member RAS oncogene family Q96DA2 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Golgi apparatus. Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network (By similarity). cytoplasm 23 0 golgi apparatus golgi apparatus Bilateria Bilateria NA RAB3A HGNC:9777 RAB3A, member RAS oncogene family P20336 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11846002,11846002,11563859,10511453,8226995,10511453 cytoplasm 26 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Bilateria Bilateria Cell.Organisms RAB3B HGNC:9778 RAB3B, member RAS oncogene family P20337 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12901864,11741295,11741295 cytoplasm 27 0 cytoplasm cytoplasm Theria Tetrapoda Cell.Organisms RAB3C HGNC:30269 RAB3C, member RAS oncogene family Q96E17 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886); Microsome (GO:0005792) 12167638,8543030,8543030,12167638,8543030 cytoplasm 23 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAB3D HGNC:9779 RAB3D, member RAS oncogene family O95716 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Secretory granule (GO:0030141); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Zymogen granule (GO:0042588) 12192047,14566969,14566969,16278343 cytoplasm 28 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms RAB3GAP1 HGNC:17063 RAB3 GTPase activating protein subunit 1 (catalytic) Q15042 Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction. Nucleus (GO:0005634) 17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota RAB3GAP2 HGNC:17168 RAB3 GTPase activating protein subunit 2 (non-catalytic) Q9H2M9 Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction. Microsome (GO:0005792); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Cytoplasmic vesicle (GO:0016023) 9733780,9733780,9733780,9733780 cytoplasm 100 0 cytoplasm. mitochondrion multiple Bilateria Eukaryota Eukaryota RAB3IL1 HGNC:9780 RAB3A interacting protein (rabin3)-like 1 Q8TBN0 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Bilateria Opisthokonta RAB3IP HGNC:16508 RAB3A interacting protein Q96QF0 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12007189,7532276,12007189 cytoplasm 17 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta RAB40A HGNC:18283 RAB40A, member RAS oncogene family Q8WXH6 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 21 0 cytoplasm cytoplasm Homininae Homininae Cell.Organisms RAB40AL HGNC:25410 RAB40A, member RAS oncogene family-like P0C0E4 Cell membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion. cytoplasm 20 0 mitochondrion mitochondrion Euteleostomi Bilateria Cell.Organisms RAB40B HGNC:18284 RAB40B, member RAS oncogene family Q12829 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms RAB40C HGNC:18285 RAB40C, member RAS oncogene family Q96S21 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 22 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms RAB41 HGNC:18293 RAB41, member RAS oncogene family Q5JT25 cytoplasm 26 0 cytoplasm cytoplasm Catarrhini Catarrhini Cell.Organisms RAB42 HGNC:28702 RAB42, member RAS oncogene family Q8N4Z0 Membrane; Lipid-anchor (Potential). cytoplasm 36 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota RAB43 HGNC:19983 RAB43, member RAS oncogene family Q86YS6 Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor (By similarity). Golgi apparatus, trans- Golgi network. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. cytoplasm 30 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Cell.Organisms RAB44 HGNC:21068 RAB44, member RAS oncogene family Q7Z6P3 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 27 0 cytoplasm cytoplasm NA NA Cell.Organisms RAB4A HGNC:9781 RAB4A, member RAS oncogene family P20338 Membrane; Peripheral membrane protein. Cytoplasm. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11788822,9524117,1425574,9524117,1425574 cytoplasm 27 0 cytoplasm. endosome multiple Opisthokonta Eukaryota Cell.Organisms RAB4B HGNC:9782 RAB4B, member RAS oncogene family P61018 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 30 0 cytoplasm cytoplasm NA NA Cell.Organisms RAB5A HGNC:9783 RAB5A, member RAS oncogene family P20339 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Early endosome membrane; Lipid-anchor (By similarity). Melanosome. Cytoplasmic vesicle (By similarity). Cell projection, ruffle (By similarity). Note=Enriched in stage I melanosomes. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endosome (GO:0005768); Cell projection (GO:0042995) 1516130,8831575,16902405,16902405 cytoplasm 25 0 cytoplasm. endosome. melanosome multiple Eukaryota Eukaryota Cell.Organisms RAB5B HGNC:9784 RAB5B, member RAS oncogene family P61020 Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes. Plasma membrane (GO:0005886); Endosome (GO:0005768) 1541686,10491193 cytoplasm 24 0 endosome. melanosome multiple Eukaryota Eukaryota Cell.Organisms RAB5C HGNC:9785 RAB5C, member RAS oncogene family P51148 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Early endosome membrane; Lipid-anchor (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endosome (GO:0005768); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Cytosol (GO:0005829) 10768959,10768959,15598749,15561729 cytoplasm 25 0 cytoplasm. endosome. melanosome. mitochondrion multiple Eukaryota Eukaryota NA RAB6A HGNC:9786 RAB6A, member RAS oncogene family P20340 Golgi apparatus membrane; Lipid-anchor. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794) 8356066,8356066,11071909,2112230,8356066,16902405 cytoplasm 23 0 golgi apparatus golgi apparatus Human Human Cell.Organisms RAB6B HGNC:14902 RAB6B, member RAS oncogene family Q9NRW1 Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. Golgi apparatus (GO:0005794); Zymogen granule (GO:0042588) 10893188,16278343 cytoplasm 25 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Cell.Organisms RAB6C HGNC:16525 RAB6C, member RAS oncogene family Q9H0N0 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737) 10455022 cytoplasm 18 0 cytoplasm. nucleus multiple NA NA Cell.Organisms RAB7A HGNC:9788 RAB7A, member RAS oncogene family P51149 Late endosome. Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Melanosome (By similarity). Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Co-localizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Endosome (GO:0005768); Lysosome (GO:0005764); Mitochondrion (GO:0005739) 8910576,10679007,15598749 vacuole 55 0 endosome. lysosome. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms RAB7B HGNC:30513 RAB7B, member RAS oncogene family Q96AH8 Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Lysosome (GO:0005764) 15144907 vacuole 29 0 endosome. golgi apparatus. lysosome multiple NA NA NA RAB7L1 HGNC:9789 RAB7, member RAS oncogene family-like 1 O14966 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 14720509,14720509 cytoplasm 20 0 golgi apparatus golgi apparatus Amniota Deuterostomia Cell.Organisms RAB8A HGNC:7007 RAB8A, member RAS oncogene family P61006 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Golgi apparatus. Cytoplasm, perinuclear region. Cell projection, cilium. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Zymogen granule (GO:0042588); Mitochondrion (GO:0005739) 12221131,12221131,12221131,17081983,16902405,16278343,15598749 cytoplasm 40 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAB8B HGNC:30273 RAB8B, member RAS oncogene family Q92930 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8799816,8799816,8799816 cytoplasm 36 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RAB9A HGNC:9792 RAB9A, member RAS oncogene family P51151 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Endoplasmic reticulum membrane (Potential). Golgi apparatus membrane (Potential). Late endosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasmic vesicle, phagosome. Note=Co-localizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis. Endosome (GO:0005768); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11827983,11827983,8389620,17081983,17081983 vacuole 37 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms RAB9B HGNC:14090 RAB9B, member RAS oncogene family Q9NP90 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. vacuole 38 0 vacuole vacuole Chordata Bilateria Cell.Organisms RABAC1 HGNC:9794 Rab acceptor 1 (prenylated) Q9UI14 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Golgi apparatus (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10329441,10329441,11096102 endoplasmic reticulum membrane 11 4 cytoplasm. golgi apparatus. plasma membrane multiple Opisthokonta Eukaryota NA RABEP1 HGNC:17677 rabaptin, RAB GTPase binding effector protein 1 Q15276 Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Endosome (GO:0005768) 17081983,17081983/8521472,8521472 cytoplasm 17 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Holozoa RABEP2 HGNC:24817 rabaptin, RAB GTPase binding effector protein 2 Q9H5N1 Cytoplasm. Early endosome. Cytoplasm (GO:0005737); Endosome (GO:0005768) 9524116,9524116 cytoplasm 18 0 cytoplasm. endosome multiple Human Human Bilateria RABEPK HGNC:16896 Rab9 effector protein with kelch motifs Q7Z6M1 Cytoplasm. Endosome membrane. Note=Interaction with PIP5K3 and subsequent phosphorylation recruits it to the endosomal membrane. Cytoplasm (GO:0005737); Endosome (GO:0005768) 9230071,9230071 cytoplasm 12 0 cytoplasm. endosome multiple Deuterostomia Eukaryota Cell.Organisms RABGAP1 HGNC:17155 RAB GTPase activating protein 1 Q9Y3P9 Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly cytosolic but also associated with the centrosome. Cytoplasm (GO:0005737); Centrosome (GO:0005813) 10202141,10202141 cytoplasm 100 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RABGAP1L HGNC:24663 RAB GTPase activating protein 1-like B7ZAP0 cytoplasm 60 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RABGEF1 HGNC:17676 RAB guanine nucleotide exchange factor (GEF) 1 Q9UJ41 Cytoplasm. Early endosome. Recycling endosome. secreted 61 0 cytoplasm. endosome multiple Opisthokonta Eukaryota Eukaryota RABGGTA HGNC:9795 Rab geranylgeranyltransferase, alpha subunit Q92696 Cytoplasm (GO:0005737) 8505342 secreted 27 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RABGGTB HGNC:9796 Rab geranylgeranyltransferase, beta subunit P53611 Cytoplasm (GO:0005737) 8505342 secreted 46 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RABIF HGNC:9797 RAB interacting factor P47224 Cytoplasm (GO:0005737) nucleus 28 0 nucleus nucleus Bilateria Eukaryota Eukaryota RABL2A HGNC:9799 RAB, member of RAS oncogene family-like 2A Q9UBK7 Plasma membrane (GO:0005886) cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms RABL2B HGNC:9800 RAB, member of RAS oncogene family-like 2B Q9UNT1 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA RABL3 HGNC:18072 RAB, member of RAS oncogene family-like 3 Q5HYI8 cytoplasm 18 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota RABL6 HGNC:24703 RAB, member RAS oncogene family-like 6 Q3YEC7 Isoform 1: Cytoplasm. Isoform 3: Nucleus. Note=Predominantly nuclear. Nucleus (GO:0005634) 17081983 cytoplasm 23 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms RAC1 HGNC:9801 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) P63000 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Cytoplasm (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By similarity). Cytoplasm (GO:0005737); Cell projection (GO:0042995); Plasma membrane (GO:0005886); Membrane fraction (GO:0005624); Zymogen granule (GO:0042588) 11590143,16902405,16902405,17245428,18716283,17215244,16278343 cytoplasm 90 0 cytoplasm. melanosome multiple Bilateria Eukaryota Cell.Organisms RAC2 HGNC:9802 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) P15153 Cytoplasm. Note=Membrane-associated when activated. Plasma membrane (GO:0005886) 2674130 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms RAC3 HGNC:9803 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) P60763 Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Plasma membrane (GO:0005886) 10618392,2674130 cytoplasm 86 0 cytoplasm cytoplasm Human Amniota Cell.Organisms RACGAP1 HGNC:9804 Rac GTPase activating protein 1 Q9H0H5 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody. Note=Colocalizes with RND2 in Golgi- derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. Nucleus (GO:0005634); Microtubule (GO:0005874) 11942621,15561729 nucleus 14 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RAD1 HGNC:9806 RAD1 homolog (S. pombe) O60671 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11994305,,11994305,15897895, nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota RAD17 HGNC:9807 RAD17 homolog (S. pombe) O75943 Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. Nucleolus (GO:0005730); Nucleus (GO:0005634) 10593953,10852904,9869296,10232579 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota NA RAD18 HGNC:18278 RAD18 homolog (S. cerevisiae) Q9NS91 Nucleus (By similarity). Nucleus (GO:0005634) 10884424,12606586,15561729 nucleus 68 0 nucleus nucleus Theria Opisthokonta Eukaryota RAD21 HGNC:9811 RAD21 homolog (S. pombe) O60216 Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Chromosome (GO:0005694) 12417729,12417729,17113138 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RAD21L1 HGNC:16271 RAD21-like 1 (S. pombe) Q9H4I0 Nucleus (By similarity). Chromosome (By similarity). Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements (By similarity). nucleus 67 0 nucleus nucleus NA NA Eukaryota RAD23A HGNC:9812 RAD23 homolog A (S. cerevisiae) P54725 Nucleus. Nucleus (GO:0005634) 10915768 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RAD23B HGNC:9813 RAD23 homolog B (S. cerevisiae) P54727 Nucleus. Cytoplasm. Note=The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S- phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8692695,8692695 nucleus 58 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAD50 HGNC:9816 RAD50 homolog (S. cerevisiae) Q92878 Nucleus. Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 11438675,11238951,8756642,17081983,11790298,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAD51 HGNC:9817 RAD51 recombinase Q06609 Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Nucleus (GO:0005634) 8816780,16395335,15065660 nucleus 64 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RAD51AP1 HGNC:16956 RAD51 associated protein 1 Q96B01 Nucleus (By similarity). Note=Colocalizes with RAD51 to multiple nuclear foci (By similarity). Nucleus (GO:0005634) 9396801,9192668 nucleus 53 0 nucleus nucleus Euteleostomi Euteleostomi Craniata RAD51AP2 HGNC:34417 RAD51 associated protein 2 Q09MP3 Nucleus (GO:0005634) 16990250 nucleus 63 0 nucleus nucleus Homininae Mammalia Boreoeutheria RAD51B HGNC:9822 RAD51 paralog B O15315 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15701685,15701685 nucleus 15 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms RAD51C HGNC:9820 RAD51 paralog C O43502 Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA. Nucleus (GO:0005634) 12118380,16395335 nucleus 17 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAD51D HGNC:9823 RAD51 paralog D O75771 Nucleus (Probable). Nucleus (GO:0005634) 11834724,15109494 nucleus 11 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms RAD52 HGNC:9824 RAD52 homolog (S. cerevisiae) P43351 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleoplasm (GO:0005654) 10673031,10673031/12750383 nucleus 30 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms RAD54B HGNC:17228 RAD54 homolog B (S. cerevisiae) Q9Y620 Nucleus (Probable). Nucleus (GO:0005634) 10851248 nucleus 32 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RAD54L HGNC:9826 RAD54-like (S. cerevisiae) Q92698 Nucleus. Nucleus (GO:0005634) 8805304 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RAD54L2 HGNC:29123 RAD54-like 2 (S. cerevisiae) Q9Y4B4 Nucleus (By similarity). Note=Localizes in speckle-like nuclear compartments (By similarity). Nucleus (GO:0005634) none,17081983 nucleus 95 0 nucleus nucleus Bilateria Eukaryota NA RAD9A HGNC:9827 RAD9 homolog A (S. pombe) Q99638 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,11994305,17081983,15897895,,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota RAD9B HGNC:21700 RAD9 homolog B (S. pombe) Q6WBX8 Nucleus (GO:0005634) 14500360 nucleus 22 0 nucleus nucleus Human Human Eukaryota RADIL HGNC:22226 Ras association and DIL domains Q96JH8 Cytoplasm (GO:0005737) cytoplasm 29 1 cytoplasm cytoplasm Mammalia Deuterostomia Holozoa RAE1 HGNC:9828 ribonucleic acid export 1 P78406 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874); Mitochondrion (GO:0005739) 9370289,9256445,9370289,9256445,9256445/10209021,15629720,11831386,10209021,15629720,11831386,15851029,15561729 nucleus 40 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RAET1E HGNC:16793 retinoic acid early transcript 1E Q8TD07 Membrane; Single-pass type I membrane protein. Isoform RAET1E2: Secreted. plasma membrane 20 1 secreted secreted Eutheria Eutheria Craniata RAET1G HGNC:16795 retinoic acid early transcript 1G Q6H3X3 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 15240696 plasma membrane 100 1 plasma membrane plasma membrane Eutheria Eutheria Craniata RAET1L HGNC:16798 retinoic acid early transcript 1L Q5VY80 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). plasma membrane 86 1 plasma membrane plasma membrane Eutheria Eutheria Craniata RAF1 HGNC:9829 v-raf-1 murine leukemia viral oncogene homolog 1 P04049 Cytoplasm. Cell membrane. Mitochondrion. Nucleus. Note=Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization. Retinoic acid- induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10497893,9819434,8349614,17081983 plasma membrane 15 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms RAG1 HGNC:9831 recombination activating gene 1 P15918 Nucleus (By similarity). Nucleus (GO:0005634) 8777717 nucleus 88 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta RAG2 HGNC:9832 recombination activating gene 2 P55895 Nucleus (By similarity). Nucleus (GO:0005634) 12861017 nucleus 86 0 nucleus nucleus Tetrapoda Euteleostomi Craniata RAI1 HGNC:9834 retinoic acid induced 1 Q7Z5J4 Cytoplasm. Nucleus. Note=In neurons, localized to neurites (By similarity). Cytoplasm (GO:0005737) 17081983 nucleus 21 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota RAI14 HGNC:14873 retinoic acid induced 14 Q9P0K7 Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity). Predominantly nuclear in nonconfluent cells. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11042181,17081983,17081983 cytoplasm 24 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms RAI2 HGNC:9835 retinoic acid induced 2 Q9Y5P3 cytoplasm 41 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Craniata RALA HGNC:9839 v-ral simian leukemia viral oncogene homolog A (ras related) P11233 Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA co-localizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody. Plasma membrane (GO:0005886); Membrane fraction (GO:0005624); Mitochondrion (GO:0005739) 10329639,17540176,15598749 cytoplasm 25 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms RALB HGNC:9840 v-ral simian leukemia viral oncogene homolog B P11234 Cell membrane; Lipid-anchor; Cytoplasmic side. Note=During late cytokinesis localizes at the midbody. Cytoplasm (GO:0005737) 8972729 cytoplasm 21 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms RALBP1 HGNC:9841 ralA binding protein 1 Q15311 Membrane; Peripheral membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12433796,11732624,17081983,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota RALGAPA1 HGNC:17770 Ral GTPase activating protein, alpha subunit 1 (catalytic) Q6GYQ0 Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated to the nucleus, when associated with TCF3/E12 (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/12200424,12200424 cytoplasm 50 2 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota RALGAPA2 HGNC:16207 Ral GTPase activating protein, alpha subunit 2 (catalytic) Q2PPJ7 Cytoplasm. cytoplasm 100 4 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RALGAPB HGNC:29221 Ral GTPase activating protein, beta subunit (non-catalytic) Q86X10 Smooth microsome (GO:0019719); Plasma membrane (GO:0005886); Rough microsome (GO:0019718); Cytosol (GO:0005829) 16490346,16490346,16490346,16490346 cytoplasm 12 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RALGDS HGNC:9842 ral guanine nucleotide dissociation stimulator Q12967 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12105416,12105416 nucleus 30 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RALGPS1 HGNC:16851 Ral GEF with PH domain and SH3 binding motif 1 Q5JS13 Cytoplasm. Cell membrane. Note=Associates with membranes through the PH domain. Integral to membrane (GO:0016021) 10889189 secreted 15 1 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms RALGPS2 HGNC:30279 Ral GEF with PH domain and SH3 binding motif 2 Q86X27 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Associates with membranes through the PH domain (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12485849,12485849,12485849 cytoplasm 17 1 cytoplasm. nucleus. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms RALY HGNC:15921 RALY heterogeneous nuclear ribonucleoprotein Q9UKM9 Nucleus (Probable). Mitochondrion (GO:0005739); Nucleus (GO:0005634); Nucleus (GO:0005634); Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15598749,15561729,17081983,19059367/17081983,17081983 nucleus 50 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms RALYL HGNC:27036 RALY RNA binding protein-like Q86SE5 nucleus 42 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms RAMP1 HGNC:9843 receptor (G protein-coupled) activity modifying protein 1 O60894 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cell surface (GO:0009986) 9620797,10385705,11535606,11535606,16293613 secreted 37 1 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Craniata RAMP2 HGNC:9844 receptor (G protein-coupled) activity modifying protein 2 O60895 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Lysosome (GO:0005764) 10882736,10882736,10882736 secreted 22 1 cytoplasm. lysosome. plasma membrane multiple Theria Euteleostomi Euteleostomi RAMP3 HGNC:9845 receptor (G protein-coupled) activity modifying protein 3 O60896 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Lysosome (GO:0005764) 10882736,10882736,10882736 secreted 14 1 cytoplasm. lysosome. plasma membrane multiple Tetrapoda Euteleostomi Craniata RAN HGNC:9846 RAN, member RAS oncogene family P62826 Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 10400640,1961752,15635413,12649209,10400640,15014887,11779226,15561729 nucleus 98 0 cytoplasm. melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RANBP1 HGNC:9847 RAN binding protein 1 P43487 Centrosome (GO:0005813); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12840069,10330396,10779340,17081983,10779340 cytoplasm 41 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RANBP10 HGNC:29285 RAN binding protein 10 Q6VN20 Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic. cytoplasm 18 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RANBP17 HGNC:14428 RAN binding protein 17 Q9H2T7 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus, nuclear pore complex (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11071879,11071879 nucleus 32 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RANBP2 HGNC:9848 RAN binding protein 2 P49792 Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Kinetochore (GO:0000776) 12393906,7775481,7603572,16332688,17081983,11792325,17081983,15598749,15561729 cytoplasm 94 0 cytoplasm. mitochondrion. nucleus multiple Chordata Chordata Cell.Organisms RANBP3 HGNC:9850 RAN binding protein 3 Q9H6Z4 Cytoplasm. Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9637251/11425870,11425870 nucleus 15 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RANBP3L HGNC:26353 RAN binding protein 3-like Q86VV4 nucleus 15 0 nucleus nucleus Amniota Amniota Eukaryota RANBP6 HGNC:9851 RAN binding protein 6 O60518 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 7 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RANBP9 HGNC:13727 RAN binding protein 9 Q96S59 Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane. Nucleus (GO:0005634) 11470507,12917623 cytoplasm 34 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RANGAP1 HGNC:9854 Ran GTPase activating protein 1 P46060 Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Kinetochore (GO:0000776); Microtubule (GO:0005874) 8978815,9019411,17081983,8978815,9019411,9442102,17000644,17081983,17363900,15561729 nucleus 34 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms RANGRF HGNC:17679 RAN guanine nucleotide release factor Q9HD47 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11290418,11733047 nucleus 16 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota RAP1A HGNC:9855 RAP1A, member of RAS oncogene family P62834 Cell membrane; Lipid-anchor. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Late endosome (GO:0005770); Lysosome (GO:0005764); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 13679863,9882515,1312373,14757755,17215244,7962206,14757755,7962206,13679863,9882515,13679863,15598749 cytoplasm 30 0 cytoplasm. endosome. lysosome. mitochondrion. nucleus multiple Eutheria Amniota Cell.Organisms RAP1B HGNC:9857 RAP1B, member of RAS oncogene family P61224 Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cell projection (GO:0042995); Zymogen granule (GO:0042588) 13679863,13679863,7803284,2123345,17318188,16278343 cytoplasm 32 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms RAP1GAP HGNC:9858 RAP1 GTPase activating protein P47736 Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12198116,12198116 cytoplasm 45 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota RAP1GAP2 HGNC:29176 RAP1 GTPase activating protein 2 Q684P5 Cytoplasm. Cytoplasm, perinuclear region. cytoplasm 100 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota RAP1GDS1 HGNC:9859 RAP1, GTP-GDP dissociation stimulator 1 P52306 nucleus 12 0 nucleus nucleus Euteleostomi Bilateria Eukaryota RAP2A HGNC:9861 RAP2A, member of RAS oncogene family P10114 Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Plasma membrane (GO:0005886) 3045729 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAP2B HGNC:9862 RAP2B, member of RAS oncogene family P61225 Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles. Plasma membrane (GO:0005886) 8391995 cytoplasm 25 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms RAP2C HGNC:21165 RAP2C, member of RAS oncogene family Q9Y3L5 Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). cytoplasm 24 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAPGEF1 HGNC:4568 Rap guanine nucleotide exchange factor (GEF) 1 Q13905 Cytoplasm (GO:0005737); Endosome (GO:0005768) 9482107,7806500,11466412 cytoplasm 20 0 cytoplasm. endosome multiple Euteleostomi Bilateria Eukaryota RAPGEF2 HGNC:16854 Rap guanine nucleotide exchange factor (GEF) 2 Q9Y4G8 Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane (By similarity). Synapse (GO:0045202); Plasma membrane (GO:0005886) 10548487,10934204 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RAPGEF3 HGNC:16629 Rap guanine nucleotide exchange factor (GEF) 3 O95398 Endomembrane system. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813); Mitochondrion (GO:0005739); Perinuclear region (GO:0048471); Cytoskeleton (GO:0005856) 12574122,12000763,12000763,12000763,15202935,15202935 nucleus 26 1 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Cell.Organisms RAPGEF4 HGNC:16626 Rap guanine nucleotide exchange factor (GEF) 4 Q8WZA2 Cytoplasm. Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 14660679,15202935 nucleus 35 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RAPGEF5 HGNC:16862 Rap guanine nucleotide exchange factor (GEF) 5 Q92565 Nucleus. Nucleus (GO:0005634) 10486569 nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Eukaryota RAPGEF6 HGNC:20655 Rap guanine nucleotide exchange factor (GEF) 6 Q8TEU7 Cytoplasm. Cell membrane. Note=Upon binding to M-Ras, it translocates to the plasma membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11524421,17081983,11524421,17081983 nucleus 24 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RAPGEFL1 HGNC:17428 Rap guanine nucleotide exchange factor (GEF)-like 1 Q9UHV5 nucleus 28 0 nucleus nucleus Theria Euteleostomi Eukaryota RAPH1 HGNC:14436 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Q70E73 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Recruited to the membrane, via the PH domain, by the phosphoinositide, PI(3,4)P2. Colocalizes with ENAH/VASP at the tips of lamellipodia and filopodia. Also colocalizes with the pathogens, Vaccinia and Enteropathogenic E.coli (EPEC) at the interface between the pathogen and their actin. Cell projection (GO:0042995) 15469845 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Opisthokonta RAPSN HGNC:9863 receptor-associated protein of the synapse Q13702 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of postsynaptic membranes. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Synapse (GO:0045202) 11323662,9520483,12388596,11323662 cytoplasm 35 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Cell.Organisms RARA HGNC:9864 retinoic acid receptor, alpha P10276 Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation. Nucleus (GO:0005634) 10760302 nucleus 74 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa RARB HGNC:9865 retinoic acid receptor, beta P10826 Isoform Beta-1: Nucleus. Isoform Beta-2: Nucleus. Isoform Beta-4: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10411930,10411930 nucleus 97 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa RARG HGNC:9866 retinoic acid receptor, gamma P13631 Nucleus. Nucleus (GO:0005634) 12399530 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa RARRES1 HGNC:9867 retinoic acid receptor responder (tazarotene induced) 1 P49788 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) secreted 20 0 secreted secreted Tetrapoda Tetrapoda Craniata RARRES2 HGNC:9868 retinoic acid receptor responder (tazarotene induced) 2 Q99969 Secreted (Potential). secreted 47 0 secreted secreted Theria Amniota Craniata RARRES3 HGNC:9869 retinoic acid receptor responder (tazarotene induced) 3 Q9UL19 Membrane; Single-pass membrane protein (By similarity). Nucleus (GO:0005634) 11078805 mitochondrion membrane 10 1 nucleus nucleus Catarrhini Euteleostomi Cell.Organisms RARS HGNC:9870 arginyl-tRNA synthetase P54136 Cytoplasm. Cytoplasm (GO:0005737); Cytosol (GO:0005829) 10358004,7590355,15561729 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RARS2 HGNC:21406 arginyl-tRNA synthetase 2, mitochondrial Q5T160 Mitochondrion matrix (By similarity). cytoplasm 28 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RASA1 HGNC:9871 RAS p21 protein activator (GTPase activating protein) 1 P20936 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8006063,8006063 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota RASA2 HGNC:9872 RAS p21 protein activator 2 Q15283 Cytoplasm. Cytoplasm, perinuclear region. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9382842,10049724,10074452 cytoplasm 100 2 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Eukaryota RASA3 HGNC:20331 RAS p21 protein activator 3 Q14644 Cell membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10869341,10869341 cytoplasm 52 2 cytoplasm. plasma membrane multiple Bilateria Bilateria Eukaryota RASA4 HGNC:23181 RAS p21 protein activator 4 O43374 Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11448776,11448776,17081983 secreted 21 2 cytoplasm. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota RASA4B HGNC:35202 RAS p21 protein activator 4B C9J798 Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By similarity). secreted 21 2 n/a n/a Euteleostomi Euteleostomi Eukaryota RASAL1 HGNC:9873 RAS protein activator like 1 (GAP1 like) O95294 endoplasmic reticulum membrane 17 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eukaryota RASAL2 HGNC:9874 RAS protein activator like 2 Q9UJF2 Nucleus (GO:0005634) 17081983 cytoplasm 20 0 nucleus nucleus Euteleostomi Bilateria Eukaryota RASAL3 HGNC:26129 RAS protein activator like 3 Q86YV0 cytoplasm 12 0 cytoplasm cytoplasm Human Mammalia Eukaryota RASD1 HGNC:15828 RAS, dexamethasone-induced 1 Q9Y272 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 11086993 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms RASD2 HGNC:18229 RASD family, member 2 Q96D21 Cell membrane; Lipid-anchor (By similarity). Plasma membrane (GO:0005886) 14724584 nucleus 14 0 nucleus nucleus Tetrapoda Bilateria Cell.Organisms RASEF HGNC:26464 RAS and EF-hand domain containing Q8IZ41 Cytoplasm, perinuclear region. cytoplasm 100 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms RASGEF1A HGNC:24246 RasGEF domain family, member 1A Q8N9B8 cytoplasm 7 0 cytoplasm cytoplasm Mammalia Tetrapoda Eukaryota RASGEF1B HGNC:24881 RasGEF domain family, member 1B Q0VAM2 Early endosome (By similarity). Late endosome (By similarity). Note=May shuttle between early and late endosomes (By similarity). nucleus 11 0 nucleus nucleus Bilateria Bilateria Eukaryota RASGEF1C HGNC:27400 RasGEF domain family, member 1C Q8N431 nucleus 15 0 nucleus nucleus Bilateria Bilateria Eukaryota RASGRF1 HGNC:9875 Ras protein-specific guanine nucleotide-releasing factor 1 Q13972 Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Synapse (GO:0045202) 14749369,14749369,14749369,9384379 cytoplasm 20 0 cytoplasm. endoplasmic reticulum multiple Euteleostomi Eukaryota Cell.Organisms RASGRF2 HGNC:9876 Ras protein-specific guanine nucleotide-releasing factor 2 O14827 Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 9032266,9032266,14749369,14749369 cytoplasm 22 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Eukaryota Cell.Organisms RASGRP1 HGNC:9878 RAS guanyl releasing protein 1 (calcium and DAG-regulated) O95267 Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). Golgi apparatus (GO:0005794) 12845332 cytoplasm 30 0 cytoplasm. golgi apparatus multiple Chordata Bilateria Cell.Organisms RASGRP2 HGNC:9879 RAS guanyl releasing protein 2 (calcium and DAG-regulated) Q7LDG7 Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome (Potential). Cell projection, ruffle membrane; Peripheral membrane protein (Potential). Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10918068,10918068 cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RASGRP3 HGNC:14545 RAS guanyl releasing protein 3 (calcium and DAG-regulated) Q8IV61 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 15213298,15213298,11221888,11221888 cytoplasm 30 0 cytoplasm. golgi apparatus. nucleus multiple Chordata Bilateria Eukaryota RASGRP4 HGNC:18958 RAS guanyl releasing protein 4 Q8TDF6 Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11956218,11880369,11956218,11880369 cytoplasm 36 1 cytoplasm. plasma membrane multiple Theria Theria Eukaryota RASIP1 HGNC:24716 Ras interacting protein 1 Q5U651 Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 15031288,15031288,15031288 secreted 10 1 cytoplasm. golgi apparatus multiple Euteleostomi Euteleostomi Metazoa RASL10A HGNC:16954 RAS-like, family 10, member A Q92737 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Nucleus, nucleolus. Note=May cycle in and out of the nucleolus in a GTP-dependent manner. Nucleolus (GO:0005730) 15833841 cytoplasm 12 0 nucleus nucleus Mammalia Mammalia Eukaryota RASL10B HGNC:30295 RAS-like, family 10, member B Q96S79 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). cytoplasm 16 0 cytoplasm cytoplasm Chordata Bilateria NA RASL11A HGNC:23802 RAS-like, family 11, member A Q6T310 Nucleus, nucleolus (By similarity). Note=Associates with rDNA transcription unit throughout the cell cycle (By similarity). nucleus 87 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms RASL11B HGNC:23804 RAS-like, family 11, member B Q9BPW5 nucleus 41 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms RASL12 HGNC:30289 RAS-like, family 12 Q9NYN1 cytoplasm 26 0 cytoplasm cytoplasm Amniota Bilateria Eukaryota RASSF1 HGNC:9882 Ras association (RalGDS/AF-6) domain family member 1 Q9NS23 Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Isoform C: Nucleus. Note=Predominantly nuclear. Cytoplasm (GO:0005737); Microtubule (GO:0005874); Nucleoplasm (GO:0005654); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 14603253,16810318,14603253,15205320,16810318,15753381,16810318,15753381,,14603253,18566590, cytoplasm 41 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Bilateria NA RASSF10 HGNC:33984 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 A6NK89 Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Bilateria NA RASSF2 HGNC:9883 Ras association (RalGDS/AF-6) domain family member 2 P50749 Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1. cytoplasm 15 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Holozoa RASSF3 HGNC:14271 Ras association (RalGDS/AF-6) domain family member 3 Q86WH2 Cytoplasm. Cytoplasm, cytoskeleton. Note=Localized to microtubules in vascular endothelial cells. cytoplasm 100 0 cytoplasm cytoplasm Human Euteleostomi Holozoa RASSF4 HGNC:20793 Ras association (RalGDS/AF-6) domain family member 4 Q9H2L5 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa RASSF5 HGNC:17609 Ras association (RalGDS/AF-6) domain family member 5 Q8WWW0 Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A. Microtubule (GO:0005874); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Immunological synapse (GO:0001772) 15569673,16892067,16892067,12845325,12845325 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata NA RASSF6 HGNC:20796 Ras association (RalGDS/AF-6) domain family member 6 Q6ZTQ3 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa RASSF7 HGNC:1166 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 Q02833 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma- tubulin. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa RASSF8 HGNC:13232 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 Q8NHQ8 cytoplasm 33 0 cytoplasm cytoplasm Deuterostomia Bilateria Eumetazoa RASSF9 HGNC:15739 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 O75901 Endosome. Note=Accumulates on perinuclear endosomes (By similarity). Cytoplasm (GO:0005737); Endosome (GO:0005768) 9837933,9837933 cytoplasm 27 0 cytoplasm. endosome multiple Tetrapoda Euteleostomi Eumetazoa RAVER1 HGNC:30296 ribonucleoprotein, PTB-binding 1 Q8IY67 Nucleus (By similarity). Cytoplasm (By similarity). Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11724819,11724819 nucleus 20 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms RAVER2 HGNC:25577 ribonucleoprotein, PTB-binding 2 Q9HCJ3 Nucleus (By similarity). Cytoplasm (By similarity). Note=May shuttle between the nucleus and the cytoplasm (By similarity). Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 16051233,16051233 nucleus 19 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms RAX HGNC:18662 retina and anterior neural fold homeobox Q9Y2V3 Nucleus. Nucleus (GO:0005634) 10625658 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota RAX2 HGNC:18286 retina and anterior neural fold homeobox 2 Q96IS3 Nucleus (By similarity). nucleus 55 0 nucleus nucleus Deuterostomia Bilateria Eukaryota RB1 HGNC:9884 retinoblastoma 1 P06400 Nucleus. Nucleus (GO:0005634) 1756735,15670817,7565761 nucleus 100 2 nucleus nucleus Amniota Eukaryota Eukaryota RB1CC1 HGNC:15574 RB1-inducible coiled-coil 1 Q8TDY2 Nucleus. Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12068296,17081983 cytoplasm 16 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa RBAK HGNC:17680 RB-associated KRAB zinc finger Q9NYW8 Nucleus. Nucleus (GO:0005634) 10702291,17000644 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota RBBP4 HGNC:9887 retinoblastoma binding protein 4 Q09028 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) ,8350924,11013263,,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RBBP5 HGNC:9888 retinoblastoma binding protein 5 Q15291 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,7558034,15199122,17081983,16253997,,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms RBBP6 HGNC:9889 retinoblastoma binding protein 6 Q7Z6E9 Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/17081983 nucleus 22 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota RBBP7 HGNC:9890 retinoblastoma binding protein 7 Q16576 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9765217,19059367,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RBBP8 HGNC:9891 retinoblastoma binding protein 8 Q99708 Nucleus. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9721205,10764811,9721205,19342888 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota RBBP8NL HGNC:16144 RBBP8 N-terminal like Q8NC74 nucleus 34 0 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi RBBP9 HGNC:9892 retinoblastoma binding protein 9 O75884 Cytoplasm. Nucleus. Nucleus (GO:0005634) secreted 46 0 cytoplasm. nucleus multiple Theria Cell.Organisms Cell.Organisms RBCK1 HGNC:15864 RanBP-type and C3HC4-type zinc finger containing 1 Q9BYM8 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15833741,15833741 cytoplasm 34 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota RBFA HGNC:26120 ribosome binding factor A (putative) Q8N0V3 Mitochondrion (Potential). nucleus 78 0 nucleus nucleus Amniota Bilateria Cell.Organisms RBFOX1 HGNC:18222 RNA binding protein, fox-1 homolog (C. elegans) 1 Q9NWB1 Nucleus (By similarity). Cytoplasm (By similarity). nucleus 58 0 nucleus nucleus Chordata Chordata Cell.Organisms RBFOX2 HGNC:9906 RNA binding protein, fox-1 homolog (C. elegans) 2 O43251 Nucleus. Cytoplasm (By similarity). Nucleus (GO:0005634) 11875103 nucleus 53 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms RBFOX3 HGNC:27097 RNA binding protein, fox-1 homolog (C. elegans) 3 A6NFN3 Nucleus (By similarity). Cytoplasm (By similarity). nucleus 50 0 nucleus nucleus Theria Euteleostomi NA RBKS HGNC:30325 ribokinase Q9H477 cytoplasm 52 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RBL1 HGNC:9893 retinoblastoma-like 1 P28749 Nucleus (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12150994,9372959,12150994,9372959,11313936 nucleus 42 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RBL2 HGNC:9894 retinoblastoma-like 2 Q08999 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11756542,11756542 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RBM10 HGNC:9896 RNA binding motif protein 10 P98175 Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains). Nucleus (GO:0005634) 8760884 nucleus 100 0 nucleus nucleus Bilateria Eukaryota NA RBM11 HGNC:9897 RNA binding motif protein 11 P57052 Nucleus, nucleoplasm. Nucleus speckle. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Cell.Organisms RBM12 HGNC:9898 RNA binding motif protein 12 Q9NTZ6 Nucleus. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11435693,11435693,17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple NA NA Eukaryota RBM12B HGNC:32310 RNA binding motif protein 12B Q8IXT5 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 secreted 21 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota RBM14 HGNC:14219 RNA binding motif protein 14 Q96PK6 Nucleus. Nucleus, nucleolus. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 17081983/11443112,17081983,11790298,17081983 nucleus 100 0 cytoplasm. nucleus multiple NA NA Cell.Organisms RBM15 HGNC:14959 RNA binding motif protein 15 Q96T37 Nucleus. nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Eukaryota RBM15B HGNC:24303 RNA binding motif protein 15B Q8NDT2 Nucleus, nucleoplasm. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Amniota Amniota NA RBM17 HGNC:16944 RNA binding motif protein 17 Q96I25 Nucleus. Nucleus (GO:0005634) 12015979,17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota RBM18 HGNC:28413 RNA binding motif protein 18 Q96H35 nucleus 25 0 nucleus nucleus Chordata Bilateria Cell.Organisms RBM19 HGNC:29098 RNA binding motif protein 19 Q9Y4C8 Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Chromosome (By similarity). Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. Nucleolus (GO:0005730) 15635413,11790298 nucleus 24 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RBM20 HGNC:27424 RNA binding motif protein 20 Q5T481 Nucleus (By similarity). nucleus 74 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota RBM22 HGNC:25503 RNA binding motif protein 22 Q9NW64 Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol. nucleus 23 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RBM23 HGNC:20155 RNA binding motif protein 23 Q86U06 Nucleus (Potential). Nucleus (GO:0005634) 15694343 nucleus 55 0 nucleus nucleus Mammalia Tetrapoda Cell.Organisms RBM24 HGNC:21539 RNA binding motif protein 24 Q9BX46 Nucleus (By similarity). Cytoplasm (By similarity). mitochondrion 32 0 mitochondrion mitochondrion Tetrapoda Eukaryota Cell.Organisms RBM25 HGNC:23244 RNA binding motif protein 25 P49756 Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint. Nucleus (GO:0005634) 15561729 nucleus 28 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms RBM26 HGNC:20327 RNA binding motif protein 26 Q5T8P6 Nucleus (GO:0005634) cytoplasm 33 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota RBM27 HGNC:29243 RNA binding motif protein 27 Q9P2N5 Cytoplasm. Nucleus speckle. Note=Incorporated into the nuclear speckles and to speckles proximal to the nuclear periphery. Also localizes to punctate structures in the cytoplasm termed cytospeckles (By similarity). nucleus 33 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota RBM28 HGNC:21863 RNA binding motif protein 28 Q9NW13 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 17081119,19059367 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RBM3 HGNC:9900 RNA binding motif (RNP1, RRM) protein 3 P98179 Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, dendrite (By similarity). Note=Localizes in mRNA granules in dentrites (By similarity). Nucleolus (GO:0005730) 15635413 nucleus 44 0 nucleus nucleus Eutheria Eukaryota NA RBM33 HGNC:27223 RNA binding motif protein 33 Q96EV2 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17000644,17081983,17081983 secreted 20 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eumetazoa RBM34 HGNC:28965 RNA binding motif protein 34 P42696 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) 15635413,15561729,17081983 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RBM38 HGNC:15818 RNA binding motif protein 38 Q9H0Z9 Cytoplasm, cytosol. Nucleus. mitochondrion 34 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms RBM39 HGNC:15923 RNA binding motif protein 39 Q14498 Nucleus speckle. Note=Concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins. Nucleolus (GO:0005730); Nucleus (GO:0005634);Nucleus (GO:0005634) 15635413,8227358,19059367/17081983 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms RBM4 HGNC:9901 RNA binding motif protein 4 Q9BWF3 Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9169144,11790298,15635413 nucleus 86 1 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms RBM41 HGNC:25617 RNA binding motif protein 41 Q96IZ5 nucleus 26 0 nucleus nucleus Theria Euteleostomi Eukaryota RBM42 HGNC:28117 RNA binding motif protein 42 Q9BTD8 Nucleus (By similarity). Cytoplasm (By similarity). Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules (By similarity). nucleus 32 0 nucleus nucleus Theria Eukaryota Cell.Organisms RBM43 HGNC:24790 RNA binding motif protein 43 Q6ZSC3 cytoplasm 42 0 cytoplasm cytoplasm Theria Amniota Euteleostomi RBM44 HGNC:24756 RNA binding motif protein 44 Q6ZP01 Cytoplasm (By similarity). Note=Detected in the intercellular bridges (By similarity). cytoplasm 47 0 cytoplasm cytoplasm Mammalia Mammalia Olfactores RBM45 HGNC:24468 RNA binding motif protein 45 Q8IUH3 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12220514,12220514 mitochondrion 20 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms RBM46 HGNC:28401 RNA binding motif protein 46 Q8TBY0 nucleus 42 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms RBM47 HGNC:30358 RNA binding motif protein 47 A0AV96 Nucleus (By similarity). nucleus 92 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms RBM48 HGNC:21785 RNA binding motif protein 48 Q5RL73 nucleus 92 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota RBM4B HGNC:28842 RNA binding motif protein 4B Q9BQ04 Nucleus. Nucleus, nucleolus. Cytoplasm (GO:0005737) 17081983 nucleus 100 1 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms RBM5 HGNC:9902 RNA binding motif protein 5 P52756 Nucleus. Nucleus (GO:0005634) 10352938,17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota RBM6 HGNC:9903 RNA binding motif protein 6 P78332 Nucleus (Probable). Nucleus (GO:0005634) 10352938,17081983 nucleus 23 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms RBM7 HGNC:9904 RNA binding motif protein 7 Q9Y580 nucleus 51 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms RBM8A HGNC:9905 RNA binding motif protein 8A Q9Y5S9 Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 17081983,17081983/11447110,11030346,15635413 cytoplasm 29 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms RBMS1 HGNC:9907 RNA binding motif, single stranded interacting protein 1 P29558 Nucleus. Nucleus (GO:0005634) 7838710 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms RBMS2 HGNC:9909 RNA binding motif, single stranded interacting protein 2 Q15434 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 69 0 cytoplasm cytoplasm Eutheria Opisthokonta Cell.Organisms RBMS3 HGNC:13427 RNA binding motif, single stranded interacting protein 3 Q6XE24 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10675610,10675610 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Opisthokonta Cell.Organisms RBMX HGNC:9910 RNA binding motif protein, X-linked P38159 Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10749975,19059367,15635413 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms RBMX2 HGNC:24282 RNA binding motif protein, X-linked 2 Q9Y388 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 26 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RBMXL1 HGNC:25073 RNA binding motif protein, X-linked-like 1 Q96E39 Nucleus (By similarity). nucleus 90 0 nucleus nucleus NA NA Cell.Organisms RBMXL2 HGNC:17886 RNA binding motif protein, X-linked-like 2 O75526 Nucleus. Nucleus (GO:0005634) 10958650,17081983 nucleus 100 0 nucleus nucleus Homininae Euarchontoglires Cell.Organisms RBMXL3 HGNC:26859 RNA binding motif protein, X-linked-like 3 Q8N7X1 nucleus 55 0 nucleus nucleus Homininae Homininae NA RBMY1A1 HGNC:9912 RNA binding motif protein, Y-linked, family 1, member A1 P0DJD3 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10749975,9547301,9547301 nucleus 100 0 cytoplasm. nucleus multiple NA NA Cell.Organisms RBMY1B HGNC:23914 RNA binding motif protein, Y-linked, family 1, member B A6NDE4 Nucleus. Nucleus (GO:0005634) 9598316,15184870 nucleus 100 0 nucleus nucleus NA NA Cell.Organisms RBMY1D HGNC:23915 RNA binding motif protein, Y-linked, family 1, member D P0C7P1 Nucleus. Nucleus (GO:0005634) 9598316,15184870 nucleus 100 0 nucleus nucleus NA NA Cell.Organisms RBMY1E HGNC:23916 RNA binding motif protein, Y-linked, family 1, member E A6NEQ0 Nucleus. Nucleus (GO:0005634) 9598316,15184870 nucleus 100 0 nucleus nucleus NA NA Cell.Organisms RBMY1F HGNC:23974 RNA binding motif protein, Y-linked, family 1, member F Q15415 Nucleus. Nucleus (GO:0005634) 15184870,9598316 nucleus 100 0 nucleus nucleus Homininae Homininae Cell.Organisms RBMY1J HGNC:23917 RNA binding motif protein, Y-linked, family 1, member J Q15415 Nucleus. Nucleus (GO:0005634) 15184870 nucleus 100 0 nucleus nucleus NA NA Cell.Organisms RBP1 HGNC:9919 retinol binding protein 1, cellular P09455 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 9452451,7666002 cytoplasm 100 0 cytoplasm. secreted multiple Deuterostomia Deuterostomia Bilateria RBP2 HGNC:9920 retinol binding protein 2, cellular P50120 Cytoplasm. Mitochondrion (GO:0005739) 1115525 cytoplasm 100 0 cytoplasm. mitochondrion multiple Euteleostomi Deuterostomia Eumetazoa RBP3 HGNC:9921 retinol binding protein 3, interstitial P10745 Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells. Extracellular (GO:0005576) 2542268 secreted 100 0 secreted secreted Euteleostomi Cell.Organisms NA RBP4 HGNC:9922 retinol binding protein 4, plasma P02753 Secreted. Extracellular (GO:0005576) 11853533,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria RBP5 HGNC:15847 retinol binding protein 5, cellular P82980 Cytoplasm (By similarity). cytoplasm 45 0 cytoplasm cytoplasm Catarrhini Tetrapoda Bilateria RBP7 HGNC:30316 retinol binding protein 7, cellular Q96R05 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12177003 cytoplasm 50 0 cytoplasm cytoplasm Theria Euteleostomi Opisthokonta RBPJ HGNC:5724 recombination signal binding protein for immunoglobulin kappa J region Q06330 Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11509665,9874765 nucleus 45 0 cytoplasm. nucleus multiple Bilateria Bilateria Opisthokonta RBPJL HGNC:13761 recombination signal binding protein for immunoglobulin kappa J region-like Q9UBG7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 85 0 nucleus nucleus Theria Opisthokonta Opisthokonta RBPMS HGNC:19097 RNA binding protein with multiple splicing Q93062 Nucleus. Cytoplasm. nucleus 52 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota RBPMS2 HGNC:19098 RNA binding protein with multiple splicing 2 Q6ZRY4 nucleus 43 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota RBX1 HGNC:9928 ring-box 1, E3 ubiquitin protein ligase P62877 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829) ,11027288,18593899,,11027288,,18593899, golgi apparatus membrane 48 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RC3H1 HGNC:29434 ring finger and CCCH-type domains 1 Q5TC82 Cytoplasm (By similarity). Note=Localizes to cytosolic RNA granules, which are sites for regulating mRNA translation and decay, suggesting that it may bind RNA (By similarity). Cytoplasm (GO:0005737) 15917799 cytoplasm 92 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RC3H2 HGNC:21461 ring finger and CCCH-type domains 2 Q9HBD1 Cytoplasm, perinuclear region. Endomembrane system. Note=Membrane-associated. Primarily localizes to the perinuclear space, probably to the endoplasmic reticulum or trans- Golgi network. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10938276,10938276 cytoplasm 94 0 cytoplasm. endoplasmic reticulum multiple Bilateria Bilateria Eukaryota RCAN1 HGNC:3040 regulator of calcineurin 1 P53805 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12225619,12225619 nucleus 48 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta RCAN2 HGNC:3041 regulator of calcineurin 2 Q14206 nucleus 48 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta RCAN3 HGNC:3042 RCAN family member 3 Q9UKA8 Cytoplasm (GO:0005737) 17081983 nucleus 51 0 cytoplasm cytoplasm Amniota Euteleostomi Opisthokonta RCBTB1 HGNC:18243 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 Q8NDN9 Nucleus (Potential). cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms RCBTB2 HGNC:1914 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 O95199 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms RCC1 HGNC:1913 regulator of chromosome condensation 1 P18754 Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10811825,17081983,15635413,,17081983,18186651, nucleus 21 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms RCC2 HGNC:30297 regulator of chromosome condensation 2 Q9P258 Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 12919680,9914378,12919680,17081983,15598749 cytoplasm 17 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Eukaryota Cell.Organisms RCCD1 HGNC:30457 RCC1 domain containing 1 A6NED2 cytoplasm 16 0 cytoplasm cytoplasm Eutheria Bilateria Cell.Organisms RCE1 HGNC:13721 Ras converting CAAX endopeptidase 1 Q9Y256 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10085068,14625273 endoplasmic reticulum membrane 100 8 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Eukaryota Eukaryota RCHY1 HGNC:17479 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase Q96PM5 Nucleus. Nucleus speckle. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 12200228,12200228,14701804 endoplasmic reticulum membrane 24 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota RCL1 HGNC:17687 RNA terminal phosphate cyclase-like 1 Q9Y2P8 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 9184239,15561729,15635413,11790298 nucleus 23 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RCN1 HGNC:9934 reticulocalbin 1, EF-hand calcium binding domain Q15293 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 8586628,15561729 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Eukaryota RCN2 HGNC:9935 reticulocalbin 2, EF-hand calcium binding domain Q14257 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 8034671,7624774,15561729 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Eukaryota RCN3 HGNC:21145 reticulocalbin 3, EF-hand calcium binding domain Q96D15 Endoplasmic reticulum lumen (Potential). endoplasmic reticulum 50 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Eukaryota RCOR1 HGNC:17441 REST corepressor 1 Q9UKL0 Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner. Nucleus (GO:0005634) none,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms RCOR2 HGNC:27455 REST corepressor 2 Q8IZ40 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Eutheria Bilateria Cell.Organisms RCOR3 HGNC:25594 REST corepressor 3 Q9P2K3 Nucleus (By similarity). Nucleus (GO:0005634) none,17081983 nucleus 58 0 nucleus nucleus Euteleostomi Bilateria Cell.Organisms RCSD1 HGNC:28310 RCSD domain containing 1 Q6JBY9 nucleus 65 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi RCVRN HGNC:9937 recoverin P35243 Cytoplasm (GO:0005737) 12507501 plasma membrane 12 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RD3 HGNC:19689 retinal degeneration 3 Q7Z3Z2 Mitochondrion (GO:0005739) 12914764 nucleus 38 0 mitochondrion mitochondrion Euteleostomi Deuterostomia Eumetazoa RD3L HGNC:40912 retinal degeneration 3-like P0DJH9 nucleus 39 0 nucleus nucleus NA NA Eumetazoa RDH10 HGNC:19975 retinol dehydrogenase 10 (all-trans) Q8IZV5 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 12407145 cytoplasm 15 4 endoplasmic reticulum endoplasmic reticulum Euteleostomi Cell.Organisms Cell.Organisms RDH11 HGNC:17964 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) Q8TC12 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum (GO:0005783) 12036956 endoplasmic reticulum membrane 100 0 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Cell.Organisms Cell.Organisms RDH12 HGNC:19977 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) Q96NR8 Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12226107,17081983 endoplasmic reticulum membrane 68 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms RDH13 HGNC:19978 retinol dehydrogenase 13 (all-trans/9-cis) Q8NBN7 endoplasmic reticulum membrane 40 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms NA RDH14 HGNC:19979 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) Q9HBH5 Endoplasmic reticulum (GO:0005783) 11256614 endoplasmic reticulum membrane 36 0 endoplasmic reticulum endoplasmic reticulum NA NA Cell.Organisms RDH16 HGNC:29674 retinol dehydrogenase 16 (all-trans) O75452 Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 9677409 cytoplasm 40 1 endoplasmic reticulum endoplasmic reticulum Bilateria Cell.Organisms Cell.Organisms RDH5 HGNC:9940 retinol dehydrogenase 5 (11-cis/9-cis) Q92781 Membrane; Peripheral membrane protein. Endoplasmic reticulum lumen. Integral to membrane (GO:0016021) 7836368 cytoplasm 36 0 endoplasmic reticulum endoplasmic reticulum Tetrapoda Euteleostomi Cell.Organisms RDH8 HGNC:14423 retinol dehydrogenase 8 (all-trans) Q9NYR8 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 15028754 cytoplasm 34 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms RDM1 HGNC:19950 RAD52 motif 1 Q8NG50 Nucleus. Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Nucleus, PML body. Nucleus, Cajal body. Note=Isoform 1 is predominantly cytoplasmic. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Nucleus (GO:0005634) 15611051 cytoplasm 43 0 cytoplasm. nucleus multiple Amniota Euteleostomi NA RDX HGNC:9944 radixin P35241 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1429901,9348291 nucleus 28 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota REC8 HGNC:16879 REC8 meiotic recombination protein O95072 Nucleus (By similarity). Chromosome (By similarity). Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity). Nucleus (GO:0005634) 10207075 nucleus 72 1 nucleus nucleus Theria Euteleostomi Eukaryota RECK HGNC:11345 reversion-inducing-cysteine-rich protein with kazal motifs O95980 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11747814,9789069 secreted 26 1 cytoplasm. plasma membrane multiple Deuterostomia Bilateria Metazoa RECQL HGNC:9948 RecQ helicase-like P46063 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 15096578,19059367,15598749 nucleus 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RECQL4 HGNC:9949 RecQ protein-like 4 O94761 Cytoplasm. Nucleus. Nucleus (GO:0005634) 9878247 nucleus 21 1 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA RECQL5 HGNC:9950 RecQ protein-like 5 O94762 Isoform Beta: Nucleus, nucleoplasm. Isoform Alpha: Cytoplasm. Isoform Gamma: Cytoplasm. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Nucleoplasm (GO:0005654) 10710432/10710432,10710432 nucleus 27 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms REEP1 HGNC:25786 receptor accessory protein 1 Q9H902 Membrane. Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum. endoplasmic reticulum membrane 64 3 endoplasmic reticulum. mitochondrion membrane multiple Euteleostomi Eukaryota Eukaryota REEP2 HGNC:17975 receptor accessory protein 2 Q9BRK0 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 47 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota REEP3 HGNC:23711 receptor accessory protein 3 Q6NUK4 Membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 48 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eukaryota REEP4 HGNC:26176 receptor accessory protein 4 Q9H6H4 Membrane; Multi-pass membrane protein (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 endoplasmic reticulum membrane 100 3 cytoplasm. nucleus multiple Mammalia Opisthokonta Eukaryota REEP5 HGNC:30077 receptor accessory protein 5 Q00765 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 23 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota REEP6 HGNC:30078 receptor accessory protein 6 Q96HR9 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 28 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Euteleostomi Eukaryota REG1A HGNC:9951 regenerating islet-derived 1 alpha P05451 Secreted. Extracellular (GO:0005576); Cytoplasmic vesicle (GO:0016023) 10348814,9823399 secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Cell.Organisms REG1B HGNC:9952 regenerating islet-derived 1 beta P48304 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Catarrhini Theria Cell.Organisms REG3A HGNC:8601 regenerating islet-derived 3 alpha Q06141 Secreted. Note=Found in the apical region of pancreatic acinar cells. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 8997243,8997243 secreted 100 0 cytoplasm. secreted multiple Eutheria Eutheria Holozoa REG3G HGNC:29595 regenerating islet-derived 3 gamma Q6UW15 Secreted. Cytoplasm (By similarity). Extracellular (GO:0005576) 12975309 secreted 81 0 secreted secreted Eutheria Eutheria Holozoa REG4 HGNC:22977 regenerating islet-derived family, member 4 Q9BYZ8 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12819006,12819006 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Tetrapoda Cell.Organisms REL HGNC:9954 v-rel avian reticuloendotheliosis viral oncogene homolog Q04864 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1740106,16319921,14678988,1740106,16319921,14678988,8139561 nucleus 69 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta RELA HGNC:9955 v-rel avian reticuloendotheliosis viral oncogene homolog A Q04206 Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15093710,15205244,16319058,17318178,15657065,14678988,8139561,10938077,10490645,12618429,16319058,17318178,15657065,17540171,9738011,14678988,8428580,19058135 nucleus 50 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa RELB HGNC:9956 v-rel avian reticuloendotheliosis viral oncogene homolog B Q01201 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Co-localizes with NEK6 in the centrosome. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11687592,14678988,,11687592,14678988,19917778, nucleus 52 0 cytoplasm. nucleus multiple Theria Amniota Holozoa RELL1 HGNC:27379 RELT-like 1 Q8IUW5 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 16389068 plasma membrane 100 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata RELL2 HGNC:26902 RELT-like 2 Q8NC24 Cell membrane; Single-pass membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Craniata RELN HGNC:9957 reelin P78509 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 12143388,11689558 secreted 94 0 secreted secreted Deuterostomia Deuterostomia Holozoa RELT HGNC:13764 RELT tumor necrosis factor receptor Q969Z4 Cell membrane; Single-pass type I membrane protein. Cytoplasm. secreted 29 1 cytoplasm. plasma membrane multiple Theria Euteleostomi Eumetazoa REM1 HGNC:15922 RAS (RAD and GEM)-like GTP-binding 1 O75628 cytoplasm 21 0 cytoplasm cytoplasm Theria Euteleostomi Cell.Organisms REM2 HGNC:20248 RAS (RAD and GEM)-like GTP binding 2 Q8IYK8 Cell membrane (By similarity). Plasma membrane (GO:0005886) 10727423 cytoplasm 20 0 cytoplasm cytoplasm Mammalia Tetrapoda Cell.Organisms REN HGNC:9958 renin P00797 Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2. Extracellular (GO:0005576) 11751703 secreted 62 0 secreted secreted Euteleostomi Bilateria Cell.Organisms RENBP HGNC:9959 renin binding protein P51606 Cytoplasm (GO:0005737) 6756682,9305888 cytoplasm 66 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms NA REP15 HGNC:33748 RAB15 effector protein Q6BDI9 Early endosome membrane. Note=Colocalizes with RAB11 and RAB15 to the endocytic recycling compartment. nucleus 13 0 nucleus nucleus Theria Tetrapoda Craniata REPIN1 HGNC:17922 replication initiator 1 Q9BWE0 Nucleus. Nucleus (GO:0005634) 8355269,2174103,10606657 nucleus 100 0 nucleus nucleus Theria Theria Eukaryota REPS1 HGNC:15578 RALBP1 associated Eps domain containing 1 Q96D71 Membrane, clathrin-coated pit. Note=Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. Cytoplasm (GO:0005737) 17081983 cytoplasm 32 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota REPS2 HGNC:9963 RALBP1 associated Eps domain containing 2 Q8NFH8 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota RER1 HGNC:30309 retention in endoplasmic reticulum sorting receptor 1 O15258 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 9309388,9309388 golgi apparatus membrane 100 4 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane multiple Eukaryota Eukaryota Eukaryota RERE HGNC:9965 arginine-glutamic acid dipeptide (RE) repeats Q9P2R6 Nucleus. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10814707,11331249,10814707 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Opisthokonta RERG HGNC:15980 RAS-like, estrogen-regulated, growth inhibitor Q96A58 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11533059,11533059 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms RERGL HGNC:26213 RERG/RAS-like Q9H628 cytoplasm 22 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota RESP18 HGNC:33762 regulated endocrine-specific protein 18 Q5W5W9 Secreted (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Note=Found in the lumen of dense core vesicles (DCV) (By similarity). secreted 75 0 secreted secreted Eutheria Eutheria Amniota REST HGNC:9966 RE1-silencing transcription factor Q13127 Nucleus (Probable). Nucleus (GO:0005634) 9756936 nucleus 18 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota RET HGNC:9967 ret proto-oncogene P07949 Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 3078962 plasma membrane 24 1 endosome membrane. plasma membrane multiple Euteleostomi Bilateria Cell.Organisms RETN HGNC:20389 resistin Q9HD89 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11994397,11201732 secreted 100 0 cytoplasm. secreted multiple Human Human Eumetazoa RETNLB HGNC:20388 resistin like beta Q9BQ08 Secreted. Extracellular (GO:0005576) 11209052 secreted 100 0 secreted secreted Euarchontoglires Theria Eumetazoa RETSAT HGNC:25991 retinol saturase (all-trans-retinol 13,14-reductase) Q6NUM9 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789); Microsome (GO:0005792); Mitochondrion (GO:0005739) 15358783,15358783,15561729 secreted 38 1 endoplasmic reticulum membrane. mitochondrion multiple Deuterostomia Cell.Organisms Cell.Organisms REV1 HGNC:14060 REV1, polymerase (DNA directed) Q9UBZ9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 16 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms REV3L HGNC:9968 REV3-like, polymerase (DNA directed), zeta, catalytic subunit O60673 Nucleus (Potential). Nucleus (GO:0005634) nucleus 12 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms REXO1 HGNC:24616 REX1, RNA exonuclease 1 homolog (S. cerevisiae) Q8N1G1 Nucleus. Nucleus (GO:0005634) 12943681 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota REXO2 HGNC:17851 RNA exonuclease 2 Q9Y3B8 Isoform 1: Mitochondrion. Isoform 2: Nucleus. Mitochondrion (GO:0005739) 10851236 mitochondrion 33 0 mitochondrion. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms REXO4 HGNC:12820 REX4, RNA exonuclease 4 homolog (S. cerevisiae) Q9GZR2 Nucleus, nucleolus. Nucleus (GO:0005634) 9325058,10908561,15561729 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota NA RFC1 HGNC:9969 replication factor C (activator 1) 1, 145kDa P35251 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12766176,16438930,15561729,15635413/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RFC2 HGNC:9970 replication factor C (activator 1) 2, 40kDa P35250 Nucleus (Probable). Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,15561729 nucleus 70 0 nucleus nucleus Cell.Organisms Cell.Organisms NA RFC3 HGNC:9971 replication factor C (activator 1) 3, 38kDa P40938 Nucleus (Probable). Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,15561729 nucleus 18 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RFC4 HGNC:9972 replication factor C (activator 1) 4, 37kDa P35249 Nucleus (Probable). Nucleus (GO:0005634); Nucleolus (GO:0005730);Nucleus (GO:0005634) 12509469,12192049,15561729,15635413/ nucleus 25 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms RFC5 HGNC:9973 replication factor C (activator 1) 5, 36.5kDa P40937 Nucleus (Probable). Nucleus (GO:0005634);Nucleolus (GO:0005730); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12171929/15635413,8692848,15561729,15598749 nucleus 50 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RFESD HGNC:29587 Rieske (Fe-S) domain containing Q8TAC1 cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms RFFL HGNC:24821 ring finger and FYVE-like domain containing E3 ubiquitin protein ligase Q8WZ73 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737);Perinuclear region (GO:0048471) 17081983/15229288 nucleus 26 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota RFK HGNC:30324 riboflavin kinase Q969G6 Cytoplasm (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RFNG HGNC:9974 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Q9Y644 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11165380,10341080 golgi apparatus membrane 36 0 secreted secreted Theria Euteleostomi Metazoa RFPL1 HGNC:9977 ret finger protein-like 1 O75677 cytoplasm 34 0 cytoplasm cytoplasm Human Human Chordata RFPL2 HGNC:9979 ret finger protein-like 2 O75678 plasma membrane 27 0 n/a n/a Catarrhini Catarrhini Chordata RFPL3 HGNC:9980 ret finger protein-like 3 O75679 plasma membrane 29 0 n/a n/a Homininae Mammalia Chordata RFPL4A HGNC:16449 ret finger protein-like 4A A6NLU0 secreted 22 0 secreted secreted NA NA Chordata RFPL4AL1 HGNC:45147 ret finger protein-like 4A-like 1 F8VTS6 secreted 22 0 secreted secreted NA NA Chordata RFPL4B HGNC:33264 ret finger protein-like 4B Q6ZWI9 plasma membrane 23 0 n/a n/a NA NA Eukaryota RFT1 HGNC:30220 RFT1 homolog (S. cerevisiae) Q96AA3 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 13 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota RFTN1 HGNC:30278 raftlin, lipid raft linker 1 Q14699 Cell membrane; Lipid-anchor. Note=Associates with lipid rafts. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12805216,17081983 nucleus 39 0 nucleus nucleus Amniota Euteleostomi Eumetazoa RFTN2 HGNC:26402 raftlin family member 2 Q52LD8 Cell membrane; Lipid-anchor (By similarity). nucleus 48 0 nucleus nucleus Human Human Eumetazoa RFWD2 HGNC:17440 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase Q8NHY2 Nucleus speckle. Cytoplasm. Note=In the nucleus, it forms nuclear speckles. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12466024,12615916,12466024,12615916 nucleus 27 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms RFWD3 HGNC:25539 ring finger and WD repeat domain 3 Q6PCD5 Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2. Nucleus (GO:0005634) 17081983 endoplasmic reticulum membrane 28 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota RFX1 HGNC:9982 regulatory factor X, 1 (influences HLA class II expression) P22670 Nucleus. Nucleus (GO:0005634) 11358531,8289803,16289097 nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Opisthokonta RFX2 HGNC:9983 regulatory factor X, 2 (influences HLA class II expression) P48378 Nucleus (Probable). Nucleus (GO:0005634) 8289803 nucleus 61 0 nucleus nucleus Opisthokonta Opisthokonta Opisthokonta RFX3 HGNC:9984 regulatory factor X, 3 (influences HLA class II expression) P48380 Nucleus (Probable). Nucleus (GO:0005634) 8289803,12411430 nucleus 99 0 nucleus nucleus Opisthokonta Opisthokonta Opisthokonta RFX4 HGNC:9985 regulatory factor X, 4 (influences HLA class II expression) Q33E94 Nucleus (By similarity). Nucleus (GO:0005634) 14701801,10706293 nucleus 96 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta RFX5 HGNC:9986 regulatory factor X, 5 (influences HLA class II expression) P48382 Nucleus. Nucleus (GO:0005634) 9118943,12968017 nucleus 100 0 nucleus nucleus Theria Euteleostomi Opisthokonta RFX6 HGNC:21478 regulatory factor X, 6 Q8HWS3 Nucleus (By similarity). nucleus 84 0 nucleus nucleus Mammalia Deuterostomia Opisthokonta RFX7 HGNC:25777 regulatory factor X, 7 Q2KHR2 Nucleus (Potential). nucleus 28 0 nucleus nucleus Tetrapoda Bilateria Opisthokonta RFX8 HGNC:37253 RFX family member 8, lacking RFX DNA binding domain Q6ZV50 Nucleus (By similarity). nucleus 17 0 nucleus nucleus Theria Amniota Opisthokonta RFXANK HGNC:9987 regulatory factor X-associated ankyrin-containing protein O14593 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9806546,15964851,11836625 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms RFXAP HGNC:9988 regulatory factor X-associated protein O00287 Nucleus. Nucleus (GO:0005634) 9118943 nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Euteleostomi RGAG1 HGNC:29245 retrotransposon gag domain containing 1 Q8NET4 secreted 15 0 secreted secreted NA NA Eukaryota RGAG4 HGNC:29430 retrotransposon gag domain containing 4 Q5HYW3 nucleus 30 0 nucleus nucleus NA NA Opisthokonta RGCC HGNC:20369 regulator of cell cycle Q9H4X1 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11687586,9756947,15713436,17081983,11687586 nucleus 71 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Euteleostomi RGL1 HGNC:30281 ral guanine nucleotide dissociation stimulator-like 1 Q9NZL6 cytoplasm 14 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RGL2 HGNC:9769 ral guanine nucleotide dissociation stimulator-like 2 O15211 cytoplasm 11 0 cytoplasm cytoplasm Theria Euteleostomi NA RGL3 HGNC:30282 ral guanine nucleotide dissociation stimulator-like 3 Q3MIN7 cytoplasm 12 0 cytoplasm cytoplasm Theria Tetrapoda Eukaryota RGL4 HGNC:31911 ral guanine nucleotide dissociation stimulator-like 4 Q8IZJ4 Cytoplasmic vesicle (By similarity). Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 12874025,12874025,12874025,12874025,12874025 cytoplasm 10 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion multiple Catarrhini Catarrhini Eukaryota RGMA HGNC:30308 repulsive guidance molecule family member a Q96B86 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). secreted 92 1 secreted secreted Deuterostomia Deuterostomia Metazoa RGMB HGNC:26896 repulsive guidance molecule family member b Q6NW40 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Membrane raft (By similarity). secreted 91 1 secreted secreted Euteleostomi Bilateria Metazoa RGN HGNC:9989 regucalcin Q15493 Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12619687,17081983,12619687 cytoplasm 86 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms NA RGP1 HGNC:21965 RGP1 retrograde golgi transport homolog (S. cerevisiae) Q92546 cytoplasm 23 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota RGPD1 HGNC:32414 RANBP2-like and GRIP domain containing 1 P0DJD0 cytoplasm 93 0 cytoplasm cytoplasm Chordata Chordata Eukaryota RGPD2 HGNC:32415 RANBP2-like and GRIP domain containing 2 P0DJD1 cytoplasm 92 0 cytoplasm cytoplasm Chordata Chordata Eukaryota RGPD3 HGNC:32416 RANBP2-like and GRIP domain containing 3 A6NKT7 cytoplasm 94 0 cytoplasm cytoplasm Chordata Chordata Eukaryota RGPD4 HGNC:32417 RANBP2-like and GRIP domain containing 4 Q7Z3J3 cytoplasm 94 0 cytoplasm cytoplasm Chordata Chordata Eukaryota RGPD5 HGNC:32418 RANBP2-like and GRIP domain containing 5 Q99666 Cytoplasm. Nucleus (GO:0005634) 11774384 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms RGPD6 HGNC:32419 RANBP2-like and GRIP domain containing 6 Q99666 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms RGPD8 HGNC:9849 RANBP2-like and GRIP domain containing 8 O14715 cytoplasm 99 0 cytoplasm cytoplasm Chordata Chordata Eukaryota RGR HGNC:9990 retinal G protein coupled receptor P47804 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 14 7 plasma membrane plasma membrane Human Chordata Eumetazoa RGS1 HGNC:9991 regulator of G-protein signaling 1 Q08116 Plasma membrane (GO:0005886); Synaptic vesicle (GO:0008021) 10480894,15215290,15215290 cytoplasm 33 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota RGS10 HGNC:9992 regulator of G-protein signaling 10 O43665 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11443111,11443111,11443111,10791963 nucleus 40 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota RGS11 HGNC:9993 regulator of G-protein signaling 11 O94810 Cytoplasm (GO:0005737) 9789084 nucleus 30 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RGS12 HGNC:9994 regulator of G-protein signaling 12 O14924 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Endosome (GO:0005768) 10869340/10869340,12024043,17380122 nucleus 100 0 endosome. nucleus multiple Chordata Bilateria Eukaryota RGS13 HGNC:9995 regulator of G-protein signaling 13 O14921 Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11875076,11875076,11875076 cytoplasm 29 0 cytoplasm. nucleus multiple Tetrapoda Opisthokonta Eukaryota RGS14 HGNC:9996 regulator of G-protein signaling 14 O43566 Nucleus (By similarity). Nucleus, PML body (By similarity). Cytoplasm. Membrane (By similarity). Cell membrane (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel- shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the nucleus in PML nuclear bodies in response to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons. Localizes to spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1- dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS1. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10953050,10953050 nucleus 36 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota RGS16 HGNC:9997 regulator of G-protein signaling 16 O15492 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12642593,10373502,12642593,10791963,10791963 cytoplasm 33 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota RGS17 HGNC:14088 regulator of G-protein signaling 17 Q9UGC6 Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity). Plasma membrane (GO:0005886) 11829488 cytoplasm 23 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota RGS18 HGNC:14261 regulator of G-protein signaling 18 Q9NS28 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11342430 cytoplasm 80 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RGS19 HGNC:13735 regulator of G-protein signaling 19 P49795 Membrane; Lipid-anchor. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 9571244,8986788,9571244,17081983 cytoplasm 29 0 golgi apparatus. nucleus multiple Tetrapoda Euteleostomi Eukaryota RGS2 HGNC:9998 regulator of G-protein signaling 2, 24kDa P41220 Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus. Isoform 4: Cell membrane. Mitochondrion. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10791963,11278586,11278586,11278586 cytoplasm 33 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Tetrapoda Eukaryota RGS20 HGNC:14600 regulator of G-protein signaling 20 O76081 Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus (By similarity). Anchored to the membrane through palmitoylation (By similarity). Plasma membrane (GO:0005886) 11735229 cytoplasm 29 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RGS21 HGNC:26839 regulator of G-protein signaling 21 Q2M5E4 cytoplasm 44 0 cytoplasm cytoplasm NA NA Eukaryota RGS22 HGNC:24499 regulator of G-protein signaling 22 Q8NE09 nucleus 63 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa RGS3 HGNC:9999 regulatorof G-protein signaling 3 P49796 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein (Potential). Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear. Nucleus (GO:0005634); Cytosol (GO:0005829); Membrane fraction (GO:0005624) 10749886,12210723,10749886,9858594,12210723,10749886,9858594 cytoplasm 30 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms RGS4 HGNC:10000 regulator of G-protein signaling 4 P49798 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12920194,9660808,12920194,9660808,10791963 cytoplasm 35 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota RGS5 HGNC:10001 regulator of G-protein signaling 5 O15539 Isoform 1: Cytoplasm. Membrane. Isoform 2: Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11253162,11253162 cytoplasm 39 0 cytoplasm cytoplasm Chordata Chordata Eukaryota RGS6 HGNC:10002 regulator of G-protein signaling 6 P49758 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 10521509,12761221,12761221 cytoplasm 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RGS7 HGNC:10003 regulator of G-protein signaling 7 P49802 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Extracellular (GO:0005576) 11032900,11152459,11032900,11152459,11152459,14718574 nucleus 20 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Eukaryota RGS7BP HGNC:23271 regulator of G-protein signaling 7 binding protein Q6MZT1 Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane; Lipid-anchor (By similarity). Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation (By similarity). nucleus 81 0 nucleus nucleus Euteleostomi Euteleostomi Deuterostomia RGS8 HGNC:16810 regulator of G-protein signaling 8 P57771 Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12110731,12110731 cytoplasm 38 0 nucleus nucleus Chordata Chordata Eukaryota RGS9 HGNC:10004 regulator of G-protein signaling 9 O75916 Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP (By similarity). Plasma membrane (GO:0005886) 9560279 cytoplasm 25 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RGS9BP HGNC:30304 regulator of G protein signaling 9 binding protein Q6ZS82 Membrane; Single-pass type IV membrane protein (By similarity). Integral to membrane (GO:0016021) secreted 34 1 secreted secreted Euteleostomi Deuterostomia Bilateria RGSL1 HGNC:18636 regulator of G-protein signaling like 1 A5PLK6 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021);Nucleus (GO:0005634) /12651916 nucleus 69 1 nucleus nucleus Amniota Chordata Metazoa RHAG HGNC:10006 Rh-associated glycoprotein Q02094 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9479501 plasma membrane 41 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms RHBDD1 HGNC:23081 rhomboid domain containing 1 Q8TEB9 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion (Potential). golgi apparatus membrane 14 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Cell.Organisms RHBDD2 HGNC:23082 rhomboid domain containing 2 Q6NTF9 Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein (By similarity). golgi apparatus membrane 85 5 golgi apparatus membrane golgi apparatus membrane Tetrapoda Tetrapoda NA RHBDD3 HGNC:1308 rhomboid domain containing 3 Q9Y3P4 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 12 5 golgi apparatus membrane golgi apparatus membrane Theria Tetrapoda Euteleostomi RHBDF1 HGNC:20561 rhomboid 5 homolog 1 (Drosophila) Q96CC6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the endoplasmic reticulum membrane. endoplasmic reticulum membrane 52 7 endoplasmic reticulum membrane. golgi apparatus membrane multiple Bilateria Cell.Organisms Cell.Organisms RHBDF2 HGNC:20788 rhomboid 5 homolog 2 (Drosophila) Q6PJF5 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell membrane. endoplasmic reticulum membrane 90 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms RHBDL1 HGNC:10007 rhomboid, veinlet-like 1 (Drosophila) O75783 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) golgi apparatus membrane 25 7 golgi apparatus membrane golgi apparatus membrane Chordata Chordata Cell.Organisms RHBDL2 HGNC:16083 rhomboid, veinlet-like 2 (Drosophila) Q9NX52 Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Chordata Eukaryota Cell.Organisms RHBDL3 HGNC:16502 rhomboid, veinlet-like 3 (Drosophila) P58872 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) golgi apparatus membrane 29 7 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Eukaryota RHBG HGNC:14572 Rh family, B glycoprotein (gene/pseudogene) Q9H310 Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Secretory granule (GO:0030141) 11024028,11024028 plasma membrane 48 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms RHCE HGNC:10008 Rh blood group, CcEe antigens P18577 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Desmosome (GO:0030057) 1379850,9087447 plasma membrane 15 12 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms RHCG HGNC:18140 Rh family, C glycoprotein Q9UBD6 Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles (By similarity). Plasma membrane (GO:0005886) 10852913 plasma membrane 100 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms RHD HGNC:10009 Rh blood group, D antigen Q02161 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1379850 plasma membrane 16 12 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms RHEB HGNC:10011 Ras homolog enriched in brain Q15382 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 9099708,16636147,16631613 cytoplasm 18 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms RHEBL1 HGNC:21166 Ras homolog enriched in brain like 1 Q8TAI7 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasm. nucleus 18 0 cytoplasm cytoplasm Eutheria Tetrapoda Cell.Organisms RHNO1 HGNC:28206 RAD9-HUS1-RAD1 interacting nuclear orphan 1 Q9BSD3 Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner. nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi RHO HGNC:10012 rhodopsin P08100 Membrane; Multi-pass membrane protein. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia. Plasma membrane (GO:0005886) 2629206 plasma membrane 5 7 plasma membrane plasma membrane Euteleostomi Bilateria Metazoa RHOA HGNC:667 ras homolog family member A P61586 Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Note=Localized to cell-cell contacts in calcium- treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner. Actin cytoskeleton (GO:0015629); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 15670823,12466390,16498402,10896672,16498402,11830497 cytoplasm 43 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms RHOB HGNC:668 ras homolog family member B P62745 Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 11149925,11149925 cytoplasm 44 0 golgi apparatus. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms RHOBTB1 HGNC:18738 Rho-related BTB domain containing 1 O94844 Cytoplasmic vesicle (GO:0016023) 14521508 cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms RHOBTB2 HGNC:18756 Rho-related BTB domain containing 2 Q9BYZ6 Cytoplasm (GO:0005737) cytoplasm 31 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms RHOBTB3 HGNC:18757 Rho-related BTB domain containing 3 O94955 Golgi apparatus. golgi apparatus 100 0 golgi apparatus golgi apparatus Tetrapoda Euteleostomi Eukaryota RHOC HGNC:669 ras homolog family member C P08134 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 7989340,7989340 cytoplasm 44 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms RHOD HGNC:670 ras homolog family member D O00212 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Endosome (GO:0005768); Plasma membrane (GO:0005886) 11350626,11484930 cytoplasm 33 0 endosome endosome Theria Theria Cell.Organisms RHOF HGNC:15703 ras homolog family member F (in filopodia) Q9HBH0 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856) 11084341,11084341 cytoplasm 38 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms RHOG HGNC:672 ras homolog family member G P84095 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9614181,9614181 cytoplasm 65 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms RHOH HGNC:686 ras homolog family member H Q15669 Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Co-localizes together with ZAP70 in the immunological synapse (By similarity). Cytoplasm (GO:0005737) 11809807 cytoplasm 26 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms RHOJ HGNC:688 ras homolog family member J Q9H4E5 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Plasma membrane (GO:0005886); Endosome (GO:0005768) 12960428,12960428 cytoplasm 50 0 endosome endosome Tetrapoda Euteleostomi Cell.Organisms RHOQ HGNC:17736 ras homolog family member Q P17081 Cytoplasm. Cell membrane; Lipid-anchor. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783) 12529401,12529401,11149925,11149925 cytoplasm 52 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus multiple Euteleostomi Euteleostomi Cell.Organisms RHOT1 HGNC:21168 ras homolog family member T1 Q8IXI2 Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria. Mitochondrion (GO:0005739) 12482879 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms RHOT2 HGNC:21169 ras homolog family member T2 Q8IXI1 Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria. Mitochondrion (GO:0005739) 12482879 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms RHOU HGNC:17794 ras homolog family member U Q7L0Q8 Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells. Cytoplasm (GO:0005737) 11459829 cytoplasm 43 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms RHOV HGNC:18313 ras homolog family member V Q96L33 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Treatment with TNF activates endosomal but not plasma membrane RHOV (By similarity). cytoplasm 42 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms RHOXF1 HGNC:29993 Rhox homeobox family, member 1 Q8NHV9 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11980563,11980563 nucleus 100 0 cytoplasm. nucleus multiple Human Eutheria NA RHOXF2 HGNC:30011 Rhox homeobox family, member 2 Q9BQY4 Nucleus (By similarity). Nucleus (GO:0005634) 11980563 nucleus 19 1 nucleus nucleus Catarrhini Catarrhini NA RHOXF2B HGNC:33519 Rhox homeobox family, member 2B P0C7M4 Nucleus (By similarity). nucleus 19 1 nucleus nucleus NA NA NA RHPN1 HGNC:19973 rhophilin, Rho GTPase binding protein 1 Q8TCX5 Cytoskeleton (GO:0005856) 12221077 cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota RHPN2 HGNC:19974 rhophilin, Rho GTPase binding protein 2 Q8IUC4 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737); Endosome (GO:0005768) 12473120,12473120 cytoplasm 100 0 cytoplasm. endosome multiple Deuterostomia Bilateria Eukaryota RIBC1 HGNC:26537 RIB43A domain with coiled-coils 1 Q8N443 cytoplasm 79 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA RIBC2 HGNC:13241 RIB43A domain with coiled-coils 2 Q9H4K1 cytoplasm 62 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RIC3 HGNC:30338 RIC3 acetylcholine receptor chaperone Q7Z5B4 Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein. Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single- pass membrane protein. Plasma membrane (GO:0005886) 12821669 endoplasmic reticulum membrane 84 1 endoplasmic reticulum membrane. golgi apparatus membrane. plasma membrane multiple Chordata Chordata Craniata RIC8A HGNC:29550 RIC8 guanine nucleotide exchange factor A Q9NPQ8 Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12652642,12509430,12652642 nucleus 67 0 cytoplasm cytoplasm Bilateria Opisthokonta Holozoa RIC8B HGNC:25555 RIC8 guanine nucleotide exchange factor B Q9NVN3 Cytoplasm, cell cortex. Note=Localizes to the cell cortex. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12652642,12652642 nucleus 67 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RICTOR HGNC:28611 RPTOR independent companion of MTOR, complex 2 Q6R327 Nucleus (GO:0005634); Myosin (GO:0016459); Cytoplasm (GO:0005737) 15302935,16221682,17081983,16221682,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota RIF1 HGNC:23207 RAP1 interacting factor homolog (yeast) Q5UIP0 Nucleus. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase. Nucleus (GO:0005634) 15342490,17081983 cytoplasm 8 2 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota RIIAD1 HGNC:26686 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 A6NNX1 nucleus 40 0 nucleus nucleus NA NA Eukaryota RILP HGNC:30266 Rab interacting lysosomal protein Q96NA2 Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. Lysosome (GO:0005764) 11179213 cytoplasm 25 0 lysosome lysosome Amniota Euteleostomi Olfactores RILPL1 HGNC:26814 Rab interacting lysosomal protein-like 1 Q5EBL4 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Amniota Bilateria Eumetazoa RILPL2 HGNC:28787 Rab interacting lysosomal protein-like 2 Q969X0 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa RIMBP2 HGNC:30339 RIMS binding protein 2 O15034 Cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Synaptic plasma membrane (By similarity). cytoplasm 17 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota RIMBP3 HGNC:29344 RIMS binding protein 3 Q9UFD9 cytoplasm 25 0 cytoplasm cytoplasm Euarchontoglires Tetrapoda Holozoa RIMBP3B HGNC:33891 RIMS binding protein 3B A6NNM3 cytoplasm 25 0 cytoplasm cytoplasm Euarchontoglires Tetrapoda Holozoa RIMBP3C HGNC:33892 RIMS binding protein 3C A6NJZ7 cytoplasm 25 0 cytoplasm cytoplasm Euarchontoglires Tetrapoda Holozoa RIMKLA HGNC:28725 ribosomal modification protein rimK-like family member A Q8IXN7 Cytoplasm (Probable). cytoplasm 58 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms RIMKLB HGNC:29228 ribosomal modification protein rimK-like family member B Q9ULI2 Cytoplasm (By similarity). cytoplasm 93 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms RIMS1 HGNC:17282 regulating synaptic membrane exocytosis 1 Q86UR5 Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle (GO:0016023) 11438518 secreted 51 0 secreted secreted Bilateria Bilateria Holozoa RIMS2 HGNC:17283 regulating synaptic membrane exocytosis 2 Q9UQ26 Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886) 14660679 secreted 92 0 secreted secreted Bilateria Bilateria Holozoa RIMS3 HGNC:21292 regulating synaptic membrane exocytosis 3 Q9UJD0 Cell junction, synapse (By similarity). Extracellular (GO:0005576); Cytoplasm (GO:0005737) ,17081983 secreted 59 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa RIMS4 HGNC:16183 regulating synaptic membrane exocytosis 4 Q9H426 Cell junction, synapse (By similarity). Extracellular (GO:0005576) secreted 57 0 secreted secreted Euteleostomi Euteleostomi Holozoa RIN1 HGNC:18749 Ras and Rab interactor 1 Q13671 Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated. Plasma membrane (GO:0005886) 7862125 secreted 16 0 cytoplasm cytoplasm Eutheria Tetrapoda Opisthokonta RIN2 HGNC:18750 Ras and Rab interactor 2 Q8WYP3 Cytoplasm (Probable). Cytoplasmic vesicle (GO:0016023) 12972505 cytoplasm 8 0 cytoplasm cytoplasm Chordata Bilateria Eukaryota RIN3 HGNC:18751 Ras and Rab interactor 3 Q8TB24 Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. Cytoplasmic vesicle (GO:0016023) 12972505 nucleus 22 0 cytoplasm. endosome multiple Tetrapoda Euteleostomi Eukaryota RING1 HGNC:10018 ring finger protein 1 Q06587 Nucleus. Nucleus speckle. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 9199346,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Theria Tetrapoda NA RINL HGNC:24795 Ras and Rab interactor-like Q6ZS11 Cell projection, ruffle (By similarity). Cytoplasmic vesicle (By similarity). nucleus 48 0 nucleus nucleus Theria Theria Opisthokonta RINT1 HGNC:21876 RAD50 interactor 1 Q6NUQ1 Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 15029241,15029241 nucleus 74 0 cytoplasm. endoplasmic reticulum multiple Opisthokonta Eukaryota Eukaryota RIOK1 HGNC:18656 RIO kinase 1 Q9BRS2 cytoplasm 38 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RIOK2 HGNC:18999 RIO kinase 2 Q9BVS4 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 13 0 cytoplasm. nucleus multiple Human Eutheria Cell.Organisms RIOK3 HGNC:11451 RIO kinase 3 O14730 cytoplasm 30 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RIPK1 HGNC:10019 receptor (TNFRSF)-interacting serine-threonine kinase 1 Q13546 Cytoplasm. Cell membrane (By similarity). Cytoplasm (GO:0005737) 10744744 plasma membrane 12 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms RIPK2 HGNC:10020 receptor-interacting serine-threonine kinase 2 O43353 Cytoplasm (Probable). Cytoplasm (GO:0005737) plasma membrane 14 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms RIPK3 HGNC:10021 receptor-interacting serine-threonine kinase 3 Q9Y572 Cytoplasm (By similarity). Cell membrane (By similarity). Mitochondrion (Potential). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10818227,10818227 plasma membrane 14 0 cytoplasm. mitochondrion multiple Eutheria Chordata Cell.Organisms RIPK4 HGNC:496 receptor-interacting serine-threonine kinase 4 P57078 Cytoplasm. Membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 11278382,11278382 nucleus 15 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms RIPPLY1 HGNC:25117 ripply transcriptional repressor 1 Q0D2K3 Nucleus (By similarity). nucleus 39 0 nucleus nucleus Euarchontoglires Euarchontoglires Eumetazoa RIPPLY2 HGNC:21390 ripply transcriptional repressor 2 Q5TAB7 Nucleus (By similarity). nucleus 39 0 nucleus nucleus Euarchontoglires Euteleostomi Eumetazoa RIPPLY3 HGNC:3047 ripply transcriptional repressor 3 P57055 Nucleus (By similarity). nucleus 40 0 nucleus nucleus Tetrapoda Euteleostomi Olfactores RIT1 HGNC:10023 Ras-like without CAAX 1 Q92963 Cell membrane. Plasma membrane (GO:0005886) 8824319 cytoplasm 32 0 cytoplasm cytoplasm Tetrapoda Bilateria Cell.Organisms RIT2 HGNC:10017 Ras-like without CAAX 2 Q99578 Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8824319,12934100,12934100 cytoplasm 28 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Cell.Organisms RITA1 HGNC:25925 RBPJ interacting and tubulin associated 1 Q96K30 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear. cytoplasm 39 0 cytoplasm. nucleus multiple Theria Chordata Eumetazoa RLBP1 HGNC:10024 retinaldehyde binding protein 1 P12271 Cytoplasm. Cytoplasm (GO:0005737) 8698076 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota RLF HGNC:10025 rearranged L-myc fusion Q13129 Nucleus (Probable). Nucleus (GO:0005634) 8545128,17000644,17081983 nucleus 12 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota RLIM HGNC:13429 ring finger protein, LIM domain interacting Q9NVW2 Nucleus. Nucleus (GO:0005634) ,10508479,19117995, nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota RLN1 HGNC:10026 relaxin 1 P04808 Secreted. Extracellular (GO:0005576) 3963064 secreted 100 0 secreted secreted Homininae Homininae Euteleostomi RLN2 HGNC:10027 relaxin 2 P04090 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11313185,7916973 secreted 100 0 cytoplasm. secreted multiple Homininae Eutheria Euteleostomi RLN3 HGNC:17135 relaxin 3 Q8WXF3 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata RLTPR HGNC:27089 RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing Q6F5E8 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms RMDN1 HGNC:24285 regulator of microtubule dynamics 1 Q96DB5 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms RMDN2 HGNC:26567 regulator of microtubule dynamics 2 Q96LZ7 Membrane; Single-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12975309,12975309 cytoplasm 19 1 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms RMDN3 HGNC:25550 regulator of microtubule dynamics 3 Q96TC7 Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 16820967,15561729 cytoplasm 19 1 cytoplasm. mitochondrion. mitochondrion membrane. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms RMI1 HGNC:25764 RecQ mediated genome instability 1 Q9H9A7 Nucleus. Note=Forms foci in response to DNA damage. Nucleus (GO:0005634) 15775963 nucleus 100 0 nucleus nucleus Chordata Opisthokonta Eukaryota RMI2 HGNC:28349 RecQ mediated genome instability 2 Q96E14 Nucleus. Note=Colocalizes with BLM at nuclear DNA repair foci. nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota RMND1 HGNC:21176 required for meiotic nuclear division 1 homolog (S. cerevisiae) Q9NWS8 Mitochondrion. mitochondrion 100 1 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms RMND5A HGNC:25850 required for meiotic nuclear division 5 homolog A (S. cerevisiae) Q9H871 Cytoplasm (GO:0005737) cytoplasm 11 1 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota RMND5B HGNC:26181 required for meiotic nuclear division 5 homolog B (S. cerevisiae) Q96G75 cytoplasm 14 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota RNASE1 HGNC:10044 ribonuclease, RNase A family, 1 (pancreatic) P07998 Secreted. Extracellular (GO:0005576) 11412105 secreted 100 0 secreted secreted Theria Theria Euteleostomi RNASE10 HGNC:19275 ribonuclease, RNase A family, 10 (non-active) Q5GAN6 Secreted (By similarity). secreted 59 0 secreted secreted Eutheria Eutheria Mammalia RNASE11 HGNC:19269 ribonuclease, RNase A family, 11 (non-active) Q8TAA1 Secreted (Potential). Extracellular (GO:0005576) secreted 15 0 secreted secreted Euarchontoglires Euarchontoglires Eutheria RNASE12 HGNC:24211 ribonuclease, RNase A family, 12 (non-active) Q5GAN4 Secreted (Probable). secreted 16 0 secreted secreted Theria Theria Euteleostomi RNASE13 HGNC:25285 ribonuclease, RNase A family, 13 (non-active) Q5GAN3 Secreted (Probable). secreted 15 0 secreted secreted Mammalia Mammalia Mammalia RNASE2 HGNC:10045 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) P10153 Lysosome (Probable). Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10741866,12606041,12606041 secreted 62 0 cytoplasm. lysosome. secreted multiple Euarchontoglires Eutheria Mammalia RNASE3 HGNC:10046 ribonuclease, RNase A family, 3 P12724 Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 3520144,11034418,11404391 secreted 100 0 cytoplasm. secreted multiple Euarchontoglires Eutheria Mammalia RNASE4 HGNC:10047 ribonuclease, RNase A family, 4 P34096 Secreted. Secretory granule (GO:0030141); Extracellular (GO:0005576) 9366257,8223579 secreted 100 0 secreted secreted Amniota Amniota Euteleostomi RNASE6 HGNC:10048 ribonuclease, RNase A family, k6 Q93091 Secreted. Extracellular (GO:0005576) 8836175 secreted 100 0 secreted secreted Theria Theria Euteleostomi RNASE7 HGNC:19278 ribonuclease, RNase A family, 7 Q9H1E1 Secreted. Extracellular (GO:0005576) 12527768,12244054 secreted 100 0 secreted secreted Catarrhini Catarrhini Euteleostomi RNASE8 HGNC:19277 ribonuclease, RNase A family, 8 Q8TDE3 Secreted (Probable). secreted 71 0 secreted secreted Theria Theria Mammalia RNASE9 HGNC:20673 ribonuclease, RNase A family, 9 (non-active) P60153 Secreted (Probable). secreted 14 0 secreted secreted Eutheria Eutheria Eutheria RNASEH1 HGNC:18466 ribonuclease H1 O60930 Cytoplasm (Potential). Nucleus (GO:0005634); Mitochondrion (GO:0005739) 9894807,12667461 mitochondrion 12 0 mitochondrion. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms RNASEH2A HGNC:18518 ribonuclease H2, subunit A O75792 Nucleus (Probable). Nucleus (GO:0005634) mitochondrion 17 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RNASEH2B HGNC:25671 ribonuclease H2, subunit B Q5TBB1 Nucleus (Probable). nucleus 78 0 nucleus nucleus Bilateria Eukaryota Eukaryota RNASEH2C HGNC:24116 ribonuclease H2, subunit C Q8TDP1 Nucleus (Probable). cytoplasm 23 0 nucleus nucleus Mammalia Eukaryota Eukaryota RNASEK HGNC:33911 ribonuclease, RNase K Q6P5S7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 44 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Holozoa RNASEL HGNC:10050 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Q05823 Cytoplasm. Mitochondrion. Cytoplasm (GO:0005737) 9366257 nucleus 16 0 cytoplasm. mitochondrion multiple Amniota Amniota Cell.Organisms RNASET2 HGNC:21686 ribonuclease T2 O00584 Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9192857,11314033 secreted 23 0 cytoplasm. endoplasmic reticulum. lysosome. secreted multiple Eukaryota Cell.Organisms Eukaryota RND1 HGNC:18314 Rho family GTPase 1 Q92730 Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 11095956,11095956 cytoplasm 26 0 cytoplasm cytoplasm Eutheria Euteleostomi Cell.Organisms RND2 HGNC:18315 Rho family GTPase 2 P52198 Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side (Potential). Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 12590651,12590651,11931639 cytoplasm 28 0 cytoplasm. endosome. golgi apparatus multiple Theria Euteleostomi Cell.Organisms RND3 HGNC:671 Rho family GTPase 3 P61587 Golgi apparatus membrane; Peripheral membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 8649376,11940653,8649376,8649376,12773565 cytoplasm 29 0 cytoplasm. golgi apparatus. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms RNF10 HGNC:10055 ring finger protein 10 Q8N5U6 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 42 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota RNF103 HGNC:12859 ring finger protein 103 O00237 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 9070305 endoplasmic reticulum membrane 100 3 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eukaryota RNF11 HGNC:10056 ring finger protein 11 Q9Y3C5 Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1 (PubMed:16123141). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14562029,14562029 plasma membrane 32 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Eukaryota RNF111 HGNC:17384 ring finger protein 111 Q6ZNA4 Nucleus. Cytoplasm. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11298453,16601693,16601693 plasma membrane 40 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota RNF112 HGNC:12968 ring finger protein 112 Q9ULX5 Membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9806830,9806830 cytoplasm 33 3 cytoplasm. nucleus multiple Mammalia Tetrapoda Eukaryota RNF113A HGNC:12974 ring finger protein 113A O15541 Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RNF113B HGNC:17267 ring finger protein 113B Q8IZP6 nucleus 31 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RNF114 HGNC:13094 ring finger protein 114 Q9Y508 cytoplasm 45 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RNF115 HGNC:18154 ring finger protein 115 Q9Y4L5 Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity). Cytoplasm (GO:0005737); Lysosome (GO:0005764) 12972561,12972561 cytoplasm 92 0 cytoplasm. lysosome multiple Theria Eukaryota Cell.Organisms RNF121 HGNC:21070 ring finger protein 121 Q9H920 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 32 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota RNF122 HGNC:21147 ring finger protein 122 Q9H9V4 Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 60 1 endoplasmic reticulum. golgi apparatus multiple Amniota Eukaryota Cell.Organisms RNF123 HGNC:21148 ring finger protein 123 Q5XPI4 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 3 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms RNF125 HGNC:21150 ring finger protein 125, E3 ubiquitin protein ligase Q96EQ8 endoplasmic reticulum membrane 48 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Eukaryota RNF126 HGNC:21151 ring finger protein 126 Q9BV68 Cytoplasm. Nucleus. endoplasmic reticulum membrane 39 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota RNF128 HGNC:21153 ring finger protein 128, E3 ubiquitin protein ligase Q8TEB7 Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). Endosome (GO:0005768); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783);Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Late endosome (GO:0005770) 12705856,12705856,12705856/12705856,12705856,12705856 cytoplasm 36 1 endoplasmic reticulum. endosome. golgi apparatus multiple Amniota Euteleostomi Cell.Organisms RNF13 HGNC:10057 ring finger protein 13 O43567 Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane; Single-pass membrane protein (By similarity). Lysosome membrane. Nucleus inner membrane (By similarity). Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane (By similarity). Nucleus (GO:0005634) nucleus 28 1 nucleus nucleus Bilateria Eukaryota Cell.Organisms RNF130 HGNC:18280 ring finger protein 130 Q86XS8 Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Mitochondrion (GO:0005739) 13679316 plasma membrane 38 1 cytoplasm. mitochondrion multiple Euteleostomi Euteleostomi Cell.Organisms RNF133 HGNC:21154 ring finger protein 133 Q8WVZ7 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Integral to membrane (GO:0016021) cytoplasm 33 1 cytoplasm cytoplasm Human Eutheria Cell.Organisms RNF135 HGNC:21158 ring finger protein 135 Q8IUD6 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota RNF138 HGNC:17765 ring finger protein 138, E3 ubiquitin protein ligase Q8WVD3 nucleus 36 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota RNF139 HGNC:17023 ring finger protein 139 Q8WU17 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9689122,17081983 endoplasmic reticulum membrane 100 16 cytoplasm. endoplasmic reticulum membrane. plasma membrane multiple Deuterostomia Bilateria Eukaryota RNF14 HGNC:10058 ring finger protein 14 Q9UBS8 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11322894,11322894 cytoplasm 14 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota RNF141 HGNC:21159 ring finger protein 141 Q8WVD5 Nucleus (GO:0005634) 12804569 plasma membrane 34 0 nucleus nucleus Euteleostomi Bilateria Eukaryota RNF144A HGNC:20457 ring finger protein 144A P50876 Membrane; Single-pass membrane protein (Potential). Nucleus (GO:0005634) cytoplasm 17 1 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RNF144B HGNC:21578 ring finger protein 144B Q7Z419 Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 12853982,12853982,12853982 cytoplasm 16 1 cytoplasm. golgi apparatus. mitochondrion membrane. plasma membrane multiple Human Euteleostomi Eukaryota RNF145 HGNC:20853 ring finger protein 145 Q96MT1 Membrane; Multi-pass membrane protein (Potential). plasma membrane 33 16 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota RNF146 HGNC:21336 ring finger protein 146 Q9NTX7 Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser- induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding. Cytoplasm (GO:0005737) 15813938 nucleus 32 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RNF148 HGNC:22411 ring finger protein 148 Q8N7C7 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 40 3 cytoplasm cytoplasm NA NA Cell.Organisms RNF149 HGNC:23137 ring finger protein 149 Q8NC42 Membrane; Single-pass membrane protein (Potential). mitochondrion membrane 34 1 mitochondrion membrane mitochondrion membrane Tetrapoda Tetrapoda Eukaryota RNF150 HGNC:23138 ring finger protein 150 Q9ULK6 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 33 1 plasma membrane plasma membrane Theria Bilateria Cell.Organisms RNF151 HGNC:23235 ring finger protein 151 Q2KHN1 Cytoplasm (By similarity). Nucleus (By similarity). cytoplasm 36 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota RNF152 HGNC:26811 ring finger protein 152 Q8N8N0 Lysosome membrane; Single-pass membrane protein (Probable). Integral to membrane (GO:0016021) cytoplasm 31 1 lysosome membrane lysosome membrane Euteleostomi Euteleostomi Metazoa RNF157 HGNC:29402 ring finger protein 157 Q96PX1 nucleus 32 0 nucleus nucleus Bilateria Eukaryota Eukaryota RNF165 HGNC:31696 ring finger protein 165 Q6ZSG1 plasma membrane 43 0 n/a n/a Amniota Euteleostomi Eukaryota RNF166 HGNC:28856 ring finger protein 166 Q96A37 nucleus 42 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota RNF167 HGNC:24544 ring finger protein 167 Q9H6Y7 Endomembrane system; Single-pass membrane protein. Note=Targeted to cytoplasmic membranes. plasma membrane 42 1 endomembrane system endomembrane system Mammalia Eukaryota Eukaryota RNF168 HGNC:26661 ring finger protein 168, E3 ubiquitin protein ligase Q8IYW5 Nucleus. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage. nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota RNF169 HGNC:26961 ring finger protein 169 Q8NCN4 Nucleus, nucleoplasm. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Chordata RNF17 HGNC:10060 ring finger protein 17 Q9BXT8 Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity). cytoplasm 5 0 cytoplasm cytoplasm Amniota Bilateria Opisthokonta RNF170 HGNC:25358 ring finger protein 170 Q96K19 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 89 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota RNF175 HGNC:27735 ring finger protein 175 Q8N4F7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 29 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota RNF180 HGNC:27752 ring finger protein 180 Q86T96 Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope (By similarity). cytoplasm 31 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Chordata Eukaryota RNF181 HGNC:28037 ring finger protein 181 Q9P0P0 plasma membrane 36 0 n/a n/a Mammalia Eukaryota Eukaryota RNF182 HGNC:28522 ring finger protein 182 Q8N6D2 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Integral to membrane (GO:0016021) cytoplasm 34 2 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RNF183 HGNC:28721 ring finger protein 183 Q96D59 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 33 1 cytoplasm cytoplasm Theria Tetrapoda Craniata RNF185 HGNC:26783 ring finger protein 185 Q96GF1 Mitochondrion outer membrane; Multi-pass membrane protein. mitochondrion membrane 100 2 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota RNF186 HGNC:25978 ring finger protein 186 Q9NXI6 Membrane; Multi-pass membrane protein (Potential). cytoplasm 30 2 cytoplasm cytoplasm Theria Theria Metazoa RNF187 HGNC:27146 ring finger protein 187 Q5TA31 Cytoplasm. Nucleus. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus. cytoplasm 19 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eutheria RNF19A HGNC:13432 ring finger protein 19A, RBR E3 ubiquitin protein ligase Q9NV58 Membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Centrosome (GO:0005813); Tubulin (GO:0045298); Perinuclear region (GO:0048471) 11237715,11237715,11237715 cytoplasm 15 2 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota RNF19B HGNC:26886 ring finger protein 19B Q6ZMZ0 Cytoplasmic granule membrane; Multi-pass membrane protein. cytoplasm 20 2 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota RNF2 HGNC:10061 ring finger protein 2 Q99496 Nucleus. Chromosome (By similarity). Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654) ,17070805 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota RNF20 HGNC:10062 ring finger protein 20, E3 ubiquitin protein ligase Q5VTR2 Nucleus (Probable). Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota RNF207 HGNC:32947 ring finger protein 207 Q6ZRF8 nucleus 18 0 nucleus nucleus Amniota Bilateria Eukaryota RNF208 HGNC:25420 ring finger protein 208 Q9H0X6 cytoplasm 30 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota RNF212 HGNC:27729 ring finger protein 212 Q495C1 Nucleus (By similarity). Chromosome (By similarity). Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). nucleus 70 0 nucleus nucleus Human Mammalia Holozoa RNF213 HGNC:14539 ring finger protein 213 Q63HN8 Cytoplasm. cytoplasm 100 4 cytoplasm cytoplasm Chordata Chordata Eukaryota RNF214 HGNC:25335 ring finger protein 214 Q8ND24 plasma membrane 22 0 n/a n/a Euteleostomi Euteleostomi Deuterostomia RNF215 HGNC:33434 ring finger protein 215 Q9Y6U7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 39 3 plasma membrane plasma membrane Amniota Deuterostomia Cell.Organisms RNF216 HGNC:21698 ring finger protein 216 Q9NWF9 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11854271,11854271 cytoplasm 100 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Eukaryota RNF217 HGNC:21487 ring finger protein 217 Q8TC41 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 17 2 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota RNF219 HGNC:20308 ring finger protein 219 Q5W0B1 Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Chordata Chordata Eukaryota RNF220 HGNC:25552 ring finger protein 220 Q5VTB9 Cytoplasm (By similarity). cytoplasm 97 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota RNF222 HGNC:34517 ring finger protein 222 A6NCQ9 Membrane; Single-pass membrane protein (Potential). cytoplasm 28 1 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota RNF223 HGNC:40020 ring finger protein 223 E7ERA6 Membrane; Single-pass membrane protein (Potential). cytoplasm 32 1 cytoplasm cytoplasm NA NA Eukaryota RNF224 HGNC:41912 ring finger protein 224 P0DH78 endoplasmic reticulum membrane 33 0 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eukaryota RNF24 HGNC:13779 ring finger protein 24 Q9Y225 Golgi apparatus membrane; Single-pass membrane protein. Nucleus (GO:0005634) golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Theria Eukaryota Eukaryota RNF25 HGNC:14662 ring finger protein 25 Q96BH1 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12748188,12748188 nucleus 38 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota RNF26 HGNC:14646 ring finger protein 26 Q9BY78 Membrane; Multi-pass membrane protein (Potential). nucleus 30 6 nucleus nucleus Eutheria Amniota Eukaryota RNF31 HGNC:16031 ring finger protein 31 Q96EP0 Cytoplasm (By similarity). cytoplasm 82 0 cytoplasm cytoplasm Theria Bilateria Eukaryota RNF32 HGNC:17118 ring finger protein 32 Q9H0A6 Cytoplasm. Cytoplasm (GO:0005737) 11890671 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RNF34 HGNC:17297 ring finger protein 34, E3 ubiquitin protein ligase Q969K3 Nucleus speckle. Endomembrane system; Peripheral membrane protein. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12118383,12118383 nucleus 26 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia NA RNF38 HGNC:18052 ring finger protein 38 Q9H0F5 endoplasmic reticulum membrane 40 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eukaryota RNF39 HGNC:18064 ring finger protein 39 Q9H2S5 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11716498 cytoplasm 77 0 cytoplasm cytoplasm Euarchontoglires Mammalia NA RNF4 HGNC:10067 ring finger protein 4 P78317 Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Nucleus (GO:0005634) 9479498 nucleus 43 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota RNF40 HGNC:16867 ring finger protein 40, E3 ubiquitin protein ligase O75150 Nucleus. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Nucleus (GO:0005634) 12121982,12121982,10944455,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota RNF41 HGNC:18401 ring finger protein 41, E3 ubiquitin protein ligase Q9H4P4 nucleus 34 0 nucleus nucleus Euteleostomi Bilateria Eukaryota RNF43 HGNC:18505 ring finger protein 43 Q68DV7 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted (PubMed:15492824). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 15492824,15492824 plasma membrane 44 1 cytoplasm. endoplasmic reticulum membrane. plasma membrane. secreted multiple Amniota Eukaryota Eukaryota RNF44 HGNC:19180 ring finger protein 44 Q7L0R7 endoplasmic reticulum membrane 40 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Eukaryota RNF5 HGNC:10068 ring finger protein 5, E3 ubiquitin protein ligase Q99942 Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Endoplasmic reticulum membrane (GO:0005789) 12861019,12861019,16901789 mitochondrion membrane 53 2 endoplasmic reticulum membrane. nucleus. plasma membrane multiple Eukaryota Eukaryota NA RNF6 HGNC:10069 ring finger protein (C3H2C3 type) 6 Q9Y252 Nucleus. Cytoplasm. Cell projection, axon (By similarity). Nucleus, PML body (By similarity). Note=Localizes to the PML nuclear bodies in Sertoli cells (By similarity). Nucleus (GO:0005634) 10331950 nucleus 34 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms RNF7 HGNC:10070 ring finger protein 7 Q9UBF6 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10082581,12470599,10082581,12470599 endoplasmic reticulum membrane 28 0 cytoplasm. nucleus multiple Human Bilateria Eukaryota RNF8 HGNC:10071 ring finger protein 8, E3 ubiquitin protein ligase O76064 Nucleus. Midbody. Chromosome, telomere (By similarity). Note=Recruited at uncapped telomeres (By similarity). Following DNA double-strand breaks, recruited to the sites of damage. During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. Nucleus (GO:0005634) 14981089,11322894 cytoplasm 39 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota RNFT1 HGNC:30206 ring finger protein, transmembrane 1 Q5M7Z0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 39 5 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota RNFT2 HGNC:25905 ring finger protein, transmembrane 2 Q96EX2 Membrane; Multi-pass membrane protein (Potential). cytoplasm 42 5 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota RNGTT HGNC:10073 RNA guanylyltransferase and 5'-phosphatase O60942 Nucleus (By similarity). Nucleus (GO:0005634) 9512541 nucleus 94 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RNH1 HGNC:10074 ribonuclease/angiogenin inhibitor 1 P13489 Cytoplasm. Cytoplasm (GO:0005737) 8264799,3219361 cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota Cell.Organisms RNLS HGNC:25641 renalase, FAD-dependent amine oxidase Q5VYX0 Secreted. Extracellular (GO:0005576) 15841207 secreted 100 0 secreted secreted Tetrapoda Deuterostomia Cell.Organisms RNMT HGNC:10075 RNA (guanine-7-) methyltransferase O43148 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7275966,11114884 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RNMTL1 HGNC:18485 RNA methyltransferase like 1 Q9HC36 mitochondrion 51 1 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms RNPC3 HGNC:18666 RNA-binding region (RNP1, RRM) containing 3 Q96LT9 Nucleus. Nucleus (GO:0005634) 14974681,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota RNPEP HGNC:10078 arginyl aminopeptidase (aminopeptidase B) Q9H4A4 Secreted (By similarity). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634) 9405297,9405297,9405297,17081983 secreted 86 0 golgi apparatus. nucleus. secreted multiple Tetrapoda Deuterostomia Cell.Organisms RNPEPL1 HGNC:10079 arginyl aminopeptidase (aminopeptidase B)-like 1 Q9HAU8 secreted 38 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms RNPS1 HGNC:10080 RNA binding protein S1, serine-rich domain Q15287 Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. Nucleus (GO:0005634) 9580558,10449421,17081983 nucleus 25 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms ROBO1 HGNC:10249 roundabout, axon guidance receptor, homolog 1 (Drosophila) Q9Y6N7 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10433822/17081983,17081983 cytoplasm 14 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Cell.Organisms ROBO2 HGNC:10250 roundabout, axon guidance receptor, homolog 2 (Drosophila) Q9HCK4 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 12504588 plasma membrane 15 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms ROBO3 HGNC:13433 roundabout, axon guidance receptor, homolog 3 (Drosophila) Q96MS0 Membrane; Single-pass type I membrane protein (Potential). secreted 16 3 n/a n/a Bilateria Bilateria Cell.Organisms ROBO4 HGNC:17985 roundabout, axon guidance receptor, homolog 4 (Drosophila) Q8WZ75 Plasma membrane (GO:0005886) 12941633 plasma membrane 11 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms ROCK1 HGNC:10251 Rho-associated, coiled-coil containing protein kinase 1 Q13464 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (By similarity). Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton (By similarity). Cell membrane (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Golgi apparatus (GO:0005794) ,14718574,12773565 cytoplasm 31 0 cytoplasm. secreted multiple Bilateria Bilateria Cell.Organisms ROCK2 HGNC:10252 Rho-associated, coiled-coil containing protein kinase 2 O75116 Cytoplasm. Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 27 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms ROGDI HGNC:29478 rogdi homolog (Drosophila) Q9GZN7 Nucleus envelope. nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta ROM1 HGNC:10254 retinal outer segment membrane protein 1 Q03395 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1610568 golgi apparatus membrane 62 4 plasma membrane plasma membrane Theria Theria Bilateria ROMO1 HGNC:16185 reactive oxygen species modulator 1 P60602 Mitochondrion inner membrane; Single-pass membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Opisthokonta Opisthokonta Opisthokonta ROPN1 HGNC:17692 rhophilin associated tail protein 1 Q9HAT0 Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity). Cell projection (GO:0042995) 10591629 nucleus 35 0 nucleus nucleus Mammalia Mammalia Eukaryota ROPN1B HGNC:31927 rhophilin associated tail protein 1B Q9BZX4 Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath (By similarity). Cytoplasm (GO:0005737); Cell projection (GO:0042995) 11278869,11278869 nucleus 31 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota ROPN1L HGNC:24060 rhophilin associated tail protein 1-like Q96C74 nucleus 26 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ROR1 HGNC:10256 receptor tyrosine kinase-like orphan receptor 1 Q01973 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1334494,8875995 plasma membrane 50 1 cytoplasm. plasma membrane multiple Bilateria Bilateria Cell.Organisms ROR2 HGNC:10257 receptor tyrosine kinase-like orphan receptor 2 Q01974 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 1334494 plasma membrane 90 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms RORA HGNC:10258 RAR-related orphan receptor A P35398 Nucleus. Nucleus (GO:0005634) 17110330 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa RORB HGNC:10259 RAR-related orphan receptor B Q92753 Nucleus (Probable). Nucleus (GO:0005634) 885817 nucleus 52 0 nucleus nucleus Amniota Bilateria Metazoa RORC HGNC:10260 RAR-related orphan receptor C P51449 Nucleus (Probable). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Theria Theria Metazoa ROS1 HGNC:10261 c-ros oncogene 1 , receptor tyrosine kinase P08922 Cell membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 2352949 cytoplasm 27 1 plasma membrane plasma membrane Euarchontoglires Bilateria Cell.Organisms RP1 HGNC:10263 retinitis pigmentosa 1 (autosomal dominant) P56715 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cell projection, cilium, photoreceptor outer segment. Note=Specifically localized in the connecting cilia of rod and cone photoreceptors. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10391212,17081983,11790298 cytoplasm 15 0 nucleus nucleus Mammalia Bilateria Eukaryota RP1L1 HGNC:15946 retinitis pigmentosa 1-like 1 Q8IWN7 Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, photoreceptor outer segment (By similarity). Note=Localized to the axoneme of outer segments and connecting cilia in rod photoreceptors (By similarity). Cell projection (GO:0042995) 12634863 plasma membrane 13 0 cytoplasm cytoplasm Theria Bilateria Eumetazoa RP2 HGNC:10274 retinitis pigmentosa 2 (X-linked recessive) O75695 Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium. Note=Detected predominantly to the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10942419,17081983 cytoplasm 13 0 nucleus nucleus Deuterostomia Eukaryota NA RP9 HGNC:10288 retinitis pigmentosa 9 (autosomal dominant) Q8TA86 Nucleus (By similarity). Nucleus (GO:0005634) 10931201 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota RPA1 HGNC:10289 replication protein A1, 70kDa P27694 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,11063722,10473346,19059367,15897895,,,15897895, nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RPA2 HGNC:10290 replication protein A2, 32kDa P15927 Nucleus. Nucleus, PML body. Note=Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,11081631,15897895,,,15897895, nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RPA3 HGNC:10291 replication protein A3, 14kDa P35244 Nucleus. Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10473346,10473346 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Metazoa RPA4 HGNC:30305 replication protein A4, 30kDa Q13156 Nucleus. Note=Localizes to DNA repair foci after DNA damage. Nucleus (GO:0005634) 7760808 nucleus 100 0 nucleus nucleus Human Human Eukaryota RPAIN HGNC:28641 RPA interacting protein Q86UA6 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Nucleus, PML body. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16008515,16135809,16135809 nucleus 30 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa RPAP1 HGNC:24567 RNA polymerase II associated protein 1 Q9BWH6 Nucleus (By similarity). cytoplasm 23 4 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota RPAP2 HGNC:25791 RNA polymerase II associated protein 2 Q8IXW5 Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. nucleus 65 1 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota RPAP3 HGNC:26151 RNA polymerase II associated protein 3 Q9H6T3 Cytoplasm (GO:0005737) 17081983 nucleus 15 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RPE HGNC:10293 ribulose-5-phosphate-3-epimerase Q96AT9 Cytoplasm (GO:0005737) 2581946 cytoplasm 47 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPE65 HGNC:10294 retinal pigment epithelium-specific protein 65kDa Q16518 Cytoplasm (By similarity). Cell membrane; Lipid-anchor (By similarity). Microsome membrane (By similarity). Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated (By similarity). Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. Endosome (GO:0005768) 9328280 mitochondrion 30 0 endosome endosome Euteleostomi Bilateria Cell.Organisms RPEL1 HGNC:45241 ribulose-5-phosphate-3-epimerase-like 1 Q2QD12 cytoplasm 44 0 cytoplasm cytoplasm NA NA NA RPF1 HGNC:30350 ribosome production factor 1 homolog (S. cerevisiae) Q9H9Y2 Nucleus, nucleolus. Nucleolus (GO:0005730) 11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RPF2 HGNC:20870 ribosome production factor 2 homolog (S. cerevisiae) Q9H7B2 Nucleus, nucleolus. Note=Associated with the nucleolus in an RNA-dependent manner. Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RPGR HGNC:10295 retinitis pigmentosa GTPase regulator Q92834 Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Golgi apparatus. Isoform 6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus (GO:0005794); Axoneme (GO:0005930); Cytosol (GO:0005829); Centriole (GO:0005814); Nucleolus (GO:0005730); Cilium (GO:0005929) 9677393,16043481,16043481,15772089,15772089,15772089,12766038,10725384,16043481 nucleus 16 0 cytoplasm. golgi apparatus. nucleus multiple Amniota Eukaryota Cell.Organisms RPGRIP1 HGNC:13436 retinitis pigmentosa GTPase regulator interacting protein 1 Q96KN7 Cell projection, cilium (By similarity). Note=Situated between the axonemal microtubules and the plasma membrane (By similarity). Cytoplasm (GO:0005737) 11104772 cytoplasm 17 0 cytoplasm cytoplasm Theria Chordata Eukaryota RPGRIP1L HGNC:29168 RPGRIP1-like Q68CZ1 Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, tight junction. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. cytoplasm 61 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota RPH3A HGNC:17056 rabphilin 3A homolog (mouse) Q9Y2J0 Cell junction, synapse (By similarity). Membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle (GO:0016023) 8060298,7707875,12937130 secreted 22 0 secreted secreted Euteleostomi Bilateria Eukaryota RPH3AL HGNC:10296 rabphilin 3A-like (without C2 domains) Q9UNE2 Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells. Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 9367993,14593078 secreted 16 0 cytoplasm cytoplasm Tetrapoda Deuterostomia NA RPIA HGNC:10297 ribose 5-phosphate isomerase A P49247 Endoplasmic reticulum (GO:0005783) 2843500 cytoplasm 50 0 endoplasmic reticulum endoplasmic reticulum Cell.Organisms Cell.Organisms Cell.Organisms RPL10 HGNC:10298 ribosomal protein L10 P27635 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Ribosome (GO:0005840); Nucleolus (GO:0005730) 9443083,9204867,12962325,9582194,9204867,15635413 cytoplasm 62 0 cytoplasm. endoplasmic reticulum. nucleus multiple Cell.Organisms Cell.Organisms NA RPL10A HGNC:10299 ribosomal protein L10a P62906 Ribosome (GO:0005840); Nucleolus (GO:0005730) 8607874,15561729,11790298,15635413 cytoplasm 50 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPL10L HGNC:17976 ribosomal protein L10-like Q96L21 Ribosome (GO:0005840) 12490704 cytoplasm 60 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL11 HGNC:10301 ribosomal protein L11 P62913 Nucleus, nucleolus (By similarity). Ribosome (GO:0005840); Nucleolus (GO:0005730); Nucleoplasm (GO:0005654); Mitochondrion (GO:0005739) none,15561729,11790298,12842086,17110929,17110929,15598749 nucleus 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL12 HGNC:10302 ribosomal protein L12 P30050 Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Ribosome (GO:0005840) 11809816,17081983,11790298,15635413,15598749,15561729 cytoplasm 64 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RPL13 HGNC:10303 ribosomal protein L13 P26373 Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 9582194,11790298,15635413,15598749,17081983 cytoplasm 42 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RPL13A HGNC:10304 ribosomal protein L13a P40429 Cytoplasm (Probable). Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10580157,15561729,11790298,15635413,14567916 cytoplasm 52 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL14 HGNC:10305 ribosomal protein L14 P50914 Ribosome (GO:0005840); Nucleolus (GO:0005730) ,11790298,15635413 cytoplasm 31 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms RPL15 HGNC:10306 ribosomal protein L15 P61313 Ribosome (GO:0005840); Nucleolus (GO:0005730) ,11790298,15635413 mitochondrion 42 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPL17 HGNC:10307 ribosomal protein L17 P18621 Ribosome (GO:0005840); Nucleolus (GO:0005730) 9582194,11790298,15635413 cytoplasm 47 0 nucleus nucleus NA NA Cell.Organisms RPL18 HGNC:10310 ribosomal protein L18 Q07020 Cytoplasm. Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) none,15561729,11790298,15635413,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms RPL18A HGNC:10311 ribosomal protein L18a Q02543 Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) ,15635413,15598749 cytoplasm 46 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RPL19 HGNC:10312 ribosomal protein L19 P84098 Ribosome (GO:0005840) 3542997,15561729 cytoplasm 53 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL21 HGNC:10313 ribosomal protein L21 P46778 Ribosome (GO:0005840); Nucleolus (GO:0005730) 7772601,15635413 cytoplasm 50 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPL22 HGNC:10315 ribosomal protein L22 P35268 Ribosome (GO:0005840); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 11056215,10712515,10712515,11790298,15635413,10712515 cytoplasm 33 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RPL22L1 HGNC:27610 ribosomal protein L22-like 1 Q6P5R6 cytoplasm 32 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RPL23 HGNC:10316 ribosomal protein L23 P62829 Ribosome (GO:0005840) 9582194 mitochondrion 26 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms RPL23A HGNC:10317 ribosomal protein L23a P62750 Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) ,11790298,15598749 mitochondrion 40 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL24 HGNC:10325 ribosomal protein L24 P83731 Ribosome (GO:0005840) 9582194 cytoplasm 49 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RPL26 HGNC:10327 ribosomal protein L26 P61254 Ribosome (GO:0005840); Nucleolus (GO:0005730) ,11790298 cytoplasm 44 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL26L1 HGNC:17050 ribosomal protein L26-like 1 Q9UNX3 Ribosome (GO:0005840); Nucleolus (GO:0005730) ,15635413 cytoplasm 44 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL27 HGNC:10328 ribosomal protein L27 P61353 Cytoplasm (GO:0005737); Nucleolus (GO:0005730) ,11790298,15635413 cytoplasm 45 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RPL27A HGNC:10329 ribosomal protein L27a P46776 Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 7772601,11790298,15598749 cytoplasm 69 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL28 HGNC:10330 ribosomal protein L28 P46779 Ribosome (GO:0005840); Nucleolus (GO:0005730) 7772601,15635413 nucleus 57 0 nucleus nucleus Theria Eukaryota Eukaryota RPL29 HGNC:10331 ribosomal protein L29 P47914 Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 8662617,11803571,11803571,15635413,15598749 cytoplasm 67 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota RPL3 HGNC:10332 ribosomal protein L3 P39023 Nucleus, nucleolus. Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Ribosome (GO:0005840) 2891103,15635413,11790298,2891103,15561729 cytoplasm 69 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL30 HGNC:10333 ribosomal protein L30 P62888 cytoplasm 47 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL31 HGNC:10334 ribosomal protein L31 P62899 Ribosome (GO:0005840); Nucleolus (GO:0005730) 2780320,12962325,11790298 cytoplasm 48 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms RPL32 HGNC:10336 ribosomal protein L32 P62910 Ribosome (GO:0005840) 12962325 nucleus 30 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPL34 HGNC:10340 ribosomal protein L34 P49207 Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12962325,15635413,15598749 cytoplasm 44 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms RPL35 HGNC:10344 ribosomal protein L35 P42766 Ribosome (GO:0005840); Nucleolus (GO:0005730) ,15635413 cytoplasm 47 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RPL35A HGNC:10345 ribosomal protein L35a P18077 Ribosome (GO:0005840); Nucleolus (GO:0005730) 12704204,15635413 cytoplasm 42 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RPL36 HGNC:13631 ribosomal protein L36 Q9Y3U8 Ribosome (GO:0005840); Nucleolus (GO:0005730) ,15635413 cytoplasm 34 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RPL36A HGNC:10359 ribosomal protein L36a P83881 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm NA NA NA RPL36AL HGNC:10346 ribosomal protein L36a-like Q969Q0 Cytoplasm (Probable). Ribosome (GO:0005840) 3396452 cytoplasm 99 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL37 HGNC:10347 ribosomal protein L37 P61927 Ribosome (GO:0005840) cytoplasm 57 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL37A HGNC:10348 ribosomal protein L37a P61513 Ribosome (GO:0005840) 8224875,1437567 cytoplasm 59 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL38 HGNC:10349 ribosomal protein L38 P63173 Ribosome (GO:0005840) 9375793 cytoplasm 46 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RPL39 HGNC:10350 ribosomal protein L39 P62891 Ribosome (GO:0005840) 8764829 mitochondrion 34 0 mitochondrion mitochondrion Eutheria Cell.Organisms Cell.Organisms RPL39L HGNC:17094 ribosomal protein L39-like Q96EH5 Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12359333,12359333,12359333 mitochondrion 34 0 cytoplasm. nucleus multiple Catarrhini Catarrhini Cell.Organisms RPL3L HGNC:10351 ribosomal protein L3-like Q92901 cytoplasm 62 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPL4 HGNC:10353 ribosomal protein L4 P36578 Ribosome (GO:0005840); Nucleolus (GO:0005730) 7575549,10964612,15635413,11790298 cytoplasm 52 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPL41 HGNC:10354 ribosomal protein L41 P62945 nucleus 68 0 nucleus nucleus NA NA NA RPL5 HGNC:10360 ribosomal protein L5 P46777 Cytoplasm. Nucleus, nucleolus. Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytosol (GO:0005829) 7772601,15561729,11790298,15635413,16263121 cytoplasm 94 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL6 HGNC:10362 ribosomal protein L6 Q02878 Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Ribosome (GO:0005840) 11790298,15635413,15598749,15561729 cytoplasm 34 1 mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota RPL7 HGNC:10363 ribosomal protein L7 P18124 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytosol (GO:0005829); Mitochondrion (GO:0005739) 7750987,7750987,8360149,15561729,11790298,15635413,16263121,15598749 cytoplasm 44 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL7A HGNC:10364 ribosomal protein L7a P62424 Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Ribosome (GO:0005840) 9030593,17081983,9030593,11790298,15635413,9030593,12543931,15561729 cytoplasm 48 0 cytoplasm. nucleus. secreted multiple Eukaryota Eukaryota NA RPL7L1 HGNC:21370 ribosomal protein L7-like 1 Q6DKI1 nucleus 23 0 nucleus nucleus Amniota Opisthokonta Cell.Organisms RPL8 HGNC:10368 ribosomal protein L8 P62917 Cytoplasm. Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 11790298,15635413,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPL9 HGNC:10369 ribosomal protein L9 P32969 Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9582194,15561729,11790298,15635413,15598749 cytoplasm 39 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPLP0 HGNC:10371 ribosomal protein, large, P0 P05388 Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Nucleus (GO:0005634); Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Cytosol (GO:0005829); Mitochondrion (GO:0005739) 12479870,6182142,15561729,11790298,6182142,12479870,16263121,15598749 nucleus 13 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPLP1 HGNC:10372 ribosomal protein, large, P1 P05386 Ribosome (GO:0005840); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 3323886,12479870,17081983,15598749,17081983 cytoplasm 30 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota RPLP2 HGNC:10377 ribosomal protein, large, P2 P05387 Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 12479870,15635413 cytoplasm 44 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RPN1 HGNC:10381 ribophorin I P04843 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytosol (GO:0005829) 10660554,3034581,17380188,16990800,16990800,15598749,16990800,16990800 endoplasmic reticulum membrane 12 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota RPN2 HGNC:10382 ribophorin II P04844 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 3034581,10660554,9642163,15598749 endoplasmic reticulum membrane 5 3 endoplasmic reticulum. mitochondrion multiple Opisthokonta Eukaryota Eukaryota RPP14 HGNC:30327 ribonuclease P/MRP 14kDa subunit O95059 Nucleus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) 10024167,15635413 nucleus 23 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa RPP21 HGNC:21300 ribonuclease P/MRP 21kDa subunit Q9H633 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11497433,11497433 nucleus 100 0 nucleus nucleus NA NA NA RPP25 HGNC:30361 ribonuclease P/MRP 25kDa subunit Q9BUL9 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12003489,15635413 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota RPP25L HGNC:19909 ribonuclease P/MRP 25kDa subunit-like Q8N5L8 Nucleus (Probable). nucleus 34 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota RPP30 HGNC:17688 ribonuclease P/MRP 30kDa subunit P78346 Nucleus, nucleolus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 9630247,17081983,15635413,17081983 nucleus 13 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota RPP38 HGNC:30329 ribonuclease P/MRP 38kDa subunit P78345 Nucleus, nucleolus (Potential). Nucleolus (GO:0005730) 15635413 nucleus 60 0 nucleus nucleus Euteleostomi Eukaryota Metazoa RPP40 HGNC:20992 ribonuclease P/MRP 40kDa subunit O75818 Nucleus, nucleolus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) 9630247,15635413 secreted 13 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota RPRD1A HGNC:25560 regulation of nuclear pre-mRNA domain containing 1A Q96P16 Nucleus (GO:0005634) 12470661 nucleus 60 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota RPRD1B HGNC:16209 regulation of nuclear pre-mRNA domain containing 1B Q9NQG5 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota RPRD2 HGNC:29039 regulation of nuclear pre-mRNA domain containing 2 Q5VT52 secreted 24 0 secreted secreted Euteleostomi Bilateria NA RPRM HGNC:24201 reprimo, TP53 dependent G2 arrest mediator candidate Q9NS64 Cytoplasm (By similarity). Membrane; Single- pass membrane protein (Potential). Cytoplasm (GO:0005737) 10930422,12395409 secreted 69 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata RPRML HGNC:32422 reprimo-like Q8N4K4 Membrane; Single-pass membrane protein (Potential). secreted 63 1 secreted secreted Euteleostomi Euteleostomi Craniata RPS10 HGNC:10383 ribosomal protein S10 P46783 Cytoplasm. Nucleus, nucleolus. Note=Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Co-localizes with NPS1 in the GC region of the nucleolus. Ribosome (GO:0005840); Nucleolus (GO:0005730) 7772601,15635413 cytoplasm 94 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RPS11 HGNC:10384 ribosomal protein S11 P62280 Ribosome (GO:0005840); Nucleolus (GO:0005730) 3267208,11790298 cytoplasm 65 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPS12 HGNC:10385 ribosomal protein S12 P25398 Cytoplasm. Ribosome (GO:0005840); Nucleolus (GO:0005730) 9582194,15561729,11790298,15635413 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RPS13 HGNC:10386 ribosomal protein S13 P62277 Ribosome (GO:0005840); Nucleolus (GO:0005730) 2403345,12054647,11790298 mitochondrion 18 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPS14 HGNC:10387 ribosomal protein S14 P62263 Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Ribosome (GO:0005840) 9152021,9152021,9152021 cytoplasm 82 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS15 HGNC:10388 ribosomal protein S15 P62841 Ribosome (GO:0005840) 3378620 cytoplasm 68 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS15A HGNC:10389 ribosomal protein S15a P62244 Ribosome (GO:0005840) 9582194,8706699 cytoplasm 72 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS16 HGNC:10396 ribosomal protein S16 P62249 Ribosome (GO:0005840); Nucleolus (GO:0005730) 2016298,15561729,11790298,15635413 cytoplasm 73 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPS17 HGNC:10397 ribosomal protein S17 P08708 Ribosome (GO:0005840); Nucleolus (GO:0005730) 8878544,15635413 cytoplasm 62 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPS17L HGNC:40029 ribosomal protein S17-like P0CW22 cytoplasm 62 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS18 HGNC:10401 ribosomal protein S18 P62269 Cytoplasm. Ribosome (GO:0005840); Nucleolus (GO:0005730) 1872840,15561729,11790298,15635413 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Cell.Organisms NA RPS19 HGNC:10402 ribosomal protein S19 P39019 Nucleus. Note=Located more specifically in the nucleoli. Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12586610,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms NA RPS19BP1 HGNC:28749 ribosomal protein S19 binding protein 1 Q86WX3 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleoplasm (GO:0005654) 16289379,16289379 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Deuterostomia RPS2 HGNC:10404 ribosomal protein S2 P15880 Ribosome (GO:0005840); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 9582194,12422231,15635413,15598749,17081983 mitochondrion 16 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS20 HGNC:10405 ribosomal protein S20 P60866 Cytoplasm (By similarity). Ribosome (GO:0005840) 9582194 cytoplasm 96 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS21 HGNC:10409 ribosomal protein S21 P63220 Ribosome (GO:0005840) 10079194 cytoplasm 67 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RPS23 HGNC:10410 ribosomal protein S23 P62266 Ribosome (GO:0005840); Nucleolus (GO:0005730) 9582194,15635413 cytoplasm 73 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPS24 HGNC:10411 ribosomal protein S24 P62847 Ribosome (GO:0005840) 1588318 cytoplasm 52 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms RPS25 HGNC:10413 ribosomal protein S25 P62851 Nucleus (GO:0005634); Ribosome (GO:0005840); Nucleolus (GO:0005730) 10050887,3378620,15561729,10050887 cytoplasm 31 0 nucleus nucleus Eukaryota Eukaryota NA RPS26 HGNC:10414 ribosomal protein S26 P62854 Ribosome (GO:0005840); Cytoplasm (GO:0005737) ,17081983 cytoplasm 63 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms RPS27 HGNC:10416 ribosomal protein S27 P42677 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleolus (GO:0005730) 8407955,17081983,none,17081983,8407955,15635413 cytoplasm 65 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS27A HGNC:10417 ribosomal protein S27a P62979 Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity). Ribosome (GO:0005840); Cytoplasm (GO:0005737) 2538756,17081983 nucleus 47 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS27L HGNC:18476 ribosomal protein S27-like Q71UM5 Ribosome (GO:0005840) cytoplasm 63 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS28 HGNC:10418 ribosomal protein S28 P62857 Ribosome (GO:0005840) 9582194 cytoplasm 75 0 cytoplasm cytoplasm NA NA Cell.Organisms RPS29 HGNC:10419 ribosomal protein S29 P62273 Ribosome (GO:0005840) cytoplasm 57 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS3 HGNC:10420 ribosomal protein S3 P23396 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Ribosome (GO:0005840) 7775413,14988002,7775413,14988002,17081983,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS3A HGNC:10421 ribosomal protein S3A P61247 Cytoplasm. Nucleus (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytosol (GO:0005829); Ribosome (GO:0005840) 10713066,10713066,17081983,11790298,16263121,15561729 cytoplasm 62 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS4X HGNC:10424 ribosomal protein S4, X-linked P62701 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytosol (GO:0005829) 1795030,11790298,16263121 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS4Y1 HGNC:10425 ribosomal protein S4, Y-linked 1 P22090 Ribosome (GO:0005840) 8139551,9582194,15561729 cytoplasm 91 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS4Y2 HGNC:18501 ribosomal protein S4, Y-linked 2 Q8TD47 Ribosome (GO:0005840) cytoplasm 90 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPS5 HGNC:10426 ribosomal protein S5 P46782 Ribosome (GO:0005840); Nucleolus (GO:0005730) 7772601,11790298,15635413 mitochondrion 21 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RPS6 HGNC:10429 ribosomal protein S6 P62753 Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytosol (GO:0005829) 710442,11790298,16263121 nucleus 80 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS6KA1 HGNC:10430 ribosomal protein S6 kinase, 90kDa, polypeptide 1 Q15418 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytosol (GO:0005829); Membrane fraction (GO:0005624) 1545823,1545823,12618428 nucleus 29 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms RPS6KA2 HGNC:10431 ribosomal protein S6 kinase, 90kDa, polypeptide 2 Q15349 Nucleus. Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7623830,7623830,15112576 nucleus 29 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms RPS6KA3 HGNC:10432 ribosomal protein S6 kinase, 90kDa, polypeptide 3 P51812 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9915826,11495723,17081983 nucleus 30 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms RPS6KA4 HGNC:10433 ribosomal protein S6 kinase, 90kDa, polypeptide 4 O75676 Nucleus. Nucleus (GO:0005634) 9792677 nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms RPS6KA5 HGNC:10434 ribosomal protein S6 kinase, 90kDa, polypeptide 5 O75582 Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9687510,9687510 nucleus 56 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms RPS6KA6 HGNC:10435 ribosomal protein S6 kinase, 90kDa, polypeptide 6 Q9UK32 Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic. nucleus 29 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms RPS6KB1 HGNC:10436 ribosomal protein S6 kinase, 70kDa, polypeptide 1 P23443 Cell junction, synapse, synaptosome (By similarity). Mitochondrion outer membrane. Mitochondrion. Isoform Alpha I: Nucleus. Cytoplasm. Isoform Alpha II: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12801526,16895915,12801526,16895915,16640565 nucleus 38 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms RPS6KB2 HGNC:10437 ribosomal protein S6 kinase, 70kDa, polypeptide 2 Q9UBS0 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11733037,11733037/12529391,12529391,15112576 nucleus 32 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms RPS6KC1 HGNC:10439 ribosomal protein S6 kinase, 52kDa, polypeptide 1 Q96S38 Cytoplasm. Membrane. Note=Also found in some small dot-like or ring-shaped early endosome structures. Cytoplasm (GO:0005737); Endosome (GO:0005768) 12077123,17081983,12077123 cytoplasm 19 0 cytoplasm. endosome multiple Bilateria Bilateria Cell.Organisms RPS6KL1 HGNC:20222 ribosomal protein S6 kinase-like 1 Q9Y6S9 nucleus 21 0 nucleus nucleus Tetrapoda Euteleostomi Cell.Organisms RPS7 HGNC:10440 ribosomal protein S7 P62081 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Co-localizes with NEK6 in the centrosome. Ribosome (GO:0005840) 9582194 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota RPS8 HGNC:10441 ribosomal protein S8 P62241 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 8706699,11790298,15635413 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPS9 HGNC:10442 ribosomal protein S9 P46781 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ribosome (GO:0005840); Nucleolus (GO:0005730) 7772601,15561729,11790298,15635413 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms NA RPSA HGNC:6502 ribosomal protein SA P08865 Cell membrane. Cytoplasm. Nucleus (By similarity). Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Co-localizes with PPP1R16B in the cell membrane. Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleolus (GO:0005730); Cytosol (GO:0005829) 8985115,8985115,15561729,11790298,15635413,16263121 cytoplasm 58 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RPTN HGNC:26809 repetin Q6XPR3 Secreted, extracellular space, extracellular matrix. secreted 100 0 secreted secreted Mammalia Chordata Cell.Organisms RPTOR HGNC:30287 regulatory associated protein of MTOR, complex 1 Q8N122 Cytoplasm. Lysosome. Note=Targeting to lysosomes depends on amino acid availability. Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983/ cytoplasm 29 2 cytoplasm. lysosome multiple Eukaryota Eukaryota Cell.Organisms RPUSD1 HGNC:14173 RNA pseudouridylate synthase domain containing 1 Q9UJJ7 cytoplasm 15 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms RPUSD2 HGNC:24180 RNA pseudouridylate synthase domain containing 2 Q8IZ73 cytoplasm 40 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RPUSD3 HGNC:28437 RNA pseudouridylate synthase domain containing 3 Q6P087 cytoplasm 20 0 cytoplasm cytoplasm Mammalia Deuterostomia Cell.Organisms RPUSD4 HGNC:25898 RNA pseudouridylate synthase domain containing 4 Q96CM3 cytoplasm 17 0 cytoplasm cytoplasm Human Cell.Organisms Cell.Organisms RQCD1 HGNC:10445 RCD1 required for cell differentiation1 homolog (S. pombe) Q92600 Nucleus (By similarity). Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body (By similarity). Nucleus (GO:0005634) 15209511 nucleus 58 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RRAD HGNC:10446 Ras-related associated with diabetes P55042 Cell membrane (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8798502,8798502 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms RRAGA HGNC:16963 Ras-related GTP binding A Q7L523 Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 8995684,8995684,8995684 nucleus 14 0 cytoplasm. lysosome. nucleus multiple Eukaryota Eukaryota Cell.Organisms RRAGB HGNC:19901 Ras-related GTP binding B Q5VZM2 Cytoplasm. Lysosome. Cytoplasm (GO:0005737) 9394008 cytoplasm 31 0 cytoplasm. lysosome multiple Eukaryota Eukaryota Cell.Organisms RRAGC HGNC:19902 Ras-related GTP binding C Q9HB90 Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11073942,11073942 nucleus 27 0 cytoplasm. lysosome. nucleus multiple Eukaryota Eukaryota Eukaryota RRAGD HGNC:19903 Ras-related GTP binding D Q9NQL2 Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11073942,11073942 golgi apparatus 19 0 cytoplasm. lysosome. nucleus multiple Eukaryota Eukaryota Eukaryota RRAS HGNC:10447 related RAS viral (r-ras) oncogene homolog P10301 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10777492,10777492 cytoplasm 27 0 endoplasmic reticulum endoplasmic reticulum Theria Euteleostomi Cell.Organisms RRAS2 HGNC:17271 related RAS viral (r-ras) oncogene homolog 2 P62070 Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12384139,12384139,17081983,12384139,17081983 cytoplasm 33 0 cytoplasm. endoplasmic reticulum. nucleus multiple Amniota Eukaryota NA RRBP1 HGNC:10448 ribosome binding protein 1 Q9P2E9 Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2165568,17081983,17081983/17081983,17081983 endoplasmic reticulum membrane 82 1 cytoplasm. endoplasmic reticulum. nucleus multiple Chordata Chordata Cell.Organisms RREB1 HGNC:10449 ras responsive element binding protein 1 Q92766 Nucleus speckle. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9305772,15302935,12482979,17000644,19059367,9305772 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota RRH HGNC:10450 retinal pigment epithelium-derived rhodopsin homolog O14718 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9275222 plasma membrane 8 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa RRM1 HGNC:10451 ribonucleotide reductase M1 P23921 Cytoplasm. Cytoplasm (GO:0005737) 12615712 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RRM2 HGNC:10452 ribonucleotide reductase M2 P31350 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12615712,12615712 cytoplasm 100 1 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RRM2B HGNC:17296 ribonucleotide reductase M2 B (TP53 inducible) Q7LG56 Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10716435,14583450,14583450,12565178 cytoplasm 76 1 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms RRN3 HGNC:30346 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) Q9NYV6 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 11250903,11250903 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RRNAD1 HGNC:24273 ribosomal RNA adenine dimethylase domain containing 1 Q96FB5 Membrane; Single-pass membrane protein (Potential). nucleus 28 1 nucleus nucleus Bilateria Cell.Organisms Eukaryota RRP1 HGNC:18785 ribosomal RNA processing 1 P56182 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 10341208,11790298,10341208,17081983 nucleus 100 0 nucleus nucleus Human Human Eukaryota RRP12 HGNC:29100 ribosomal RNA processing 12 homolog (S. cerevisiae) Q5JTH9 Nucleus, nucleolus. Nucleus membrane; Single-pass membrane protein (Potential). Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,11790298,15561729 nucleus 94 1 nucleus nucleus Eukaryota Eukaryota Eukaryota RRP15 HGNC:24255 ribosomal RNA processing 15 homolog (S. cerevisiae) Q9Y3B9 Nucleolus (GO:0005730); Cytosol (GO:0005829) 11790298,15561729 nucleus 20 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota RRP1B HGNC:23818 ribosomal RNA processing 1B Q14684 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,11790298,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RRP36 HGNC:21374 ribosomal RNA processing 36 homolog (S. cerevisiae) Q96EU6 Nucleus, nucleolus. Note=Concentrated in the fibrillar region of the nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,17081983 nucleus 100 0 nucleus nucleus Catarrhini Eukaryota Eukaryota RRP7A HGNC:24286 ribosomal RNA processing 7 homolog A (S. cerevisiae) Q9Y3A4 Nucleolus (GO:0005730); Nucleus (GO:0005634) 11790298,15561729 nucleus 12 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota RRP8 HGNC:29030 ribosomal RNA processing 8, methyltransferase, homolog (yeast) O43159 Nucleus, nucleolus. Note=Localizes at rDNA locus. Nucleolus (GO:0005730) 11790298 nucleus 100 0 nucleus nucleus Eutheria Eukaryota Eukaryota RRP9 HGNC:16829 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) O43818 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9418896,15635413,11790298,15561729,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RRS1 HGNC:17083 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) Q15050 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Ribosome (GO:0005840) ,15635413,11790298,15561729 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RS1 HGNC:10457 retinoschisin 1 O15537 Secreted. Extracellular (GO:0005576) 10915776 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eukaryota RSAD1 HGNC:25634 radical S-adenosyl methionine domain containing 1 Q9HA92 Mitochondrion (Potential). cytoplasm 13 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms RSAD2 HGNC:30908 radical S-adenosyl methionine domain containing 2 Q8WXG1 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Endoplasmic reticulum. Lipid droplet (By similarity). Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11752458,11752458,11752458 cytoplasm 26 2 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion multiple Euteleostomi Eukaryota Cell.Organisms RSBN1 HGNC:25642 round spermatid basic protein 1 Q5VWQ0 Nucleus (By similarity). Nucleus (GO:0005634) 14724137,17000644 nucleus 94 0 nucleus nucleus Bilateria Bilateria Holozoa RSBN1L HGNC:24765 round spermatid basic protein 1-like Q6PCB5 Nucleus (By similarity). nucleus 56 0 nucleus nucleus Bilateria Bilateria Holozoa RSC1A1 HGNC:10458 regulatory solute carrier protein, family 1, member 1 Q92681 Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane. Nucleus (GO:0005634); Plasma membrane (GO:0005886) 14724758,14724758,11018680 nucleus 73 0 golgi apparatus. nucleus multiple Homininae Amniota Euteleostomi RSF1 HGNC:18118 remodeling and spacing factor 1 Q96T23 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12972596,15242768,11788598,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota RSG1 HGNC:28127 REM2 and RAB-like small GTPase 1 Q9BU20 Cytoplasm, cytoskeleton, cilium basal body (By similarity). cytoplasm 51 0 cytoplasm cytoplasm Theria Deuterostomia Eukaryota RSL1D1 HGNC:24534 ribosomal L1 domain containing 1 O76021 Nucleus, nucleolus. Nucleolus (GO:0005730); Ribosome (GO:0005840); Nucleus (GO:0005634); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,11790298,15561729,17081983,19059367,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota RSL24D1 HGNC:18479 ribosomal L24 domain containing 1 Q9UHA3 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleolus (GO:0005730) ,,,15635413 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms RSPH1 HGNC:12371 radial spoke head 1 homolog (Chlamydomonas) Q8WYR4 Cytoplasm (By similarity). Note=Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9578619,9578619 cytoplasm 56 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms RSPH10B HGNC:27362 radial spoke head 10 homolog B (Chlamydomonas) P0C881 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms RSPH10B2 HGNC:34385 radial spoke head 10 homolog B2 (Chlamydomonas) B2RC85 cytoplasm 17 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms RSPH3 HGNC:21054 radial spoke 3 homolog (Chlamydomonas) Q86UC2 cytoplasm 36 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RSPH4A HGNC:21558 radial spoke head 4 homolog A (Chlamydomonas) Q5TD94 Cytoplasm, cytoskeleton, cilium axoneme (Probable). Note=Radial spoke (Probable). cytoplasm 23 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RSPH6A HGNC:14241 radial spoke head 6 homolog A (Chlamydomonas) Q9H0K4 cytoplasm 25 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RSPH9 HGNC:21057 radial spoke head 9 homolog (Chlamydomonas) Q9H1X1 Cytoplasm, cytoskeleton, cilium axoneme (Probable). Note=Radial spoke (Probable). nucleus 27 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RSPO1 HGNC:21679 R-spondin 1 Q2MKA7 Secreted (By similarity). Extracellular (GO:0005576) 16357527 secreted 39 0 secreted secreted Amniota Euteleostomi Eukaryota RSPO2 HGNC:28583 R-spondin 2 Q6UXX9 Secreted (By similarity). Extracellular (GO:0005576) 16357527,15469841 secreted 95 0 secreted secreted Tetrapoda Euteleostomi Eukaryota RSPO3 HGNC:20866 R-spondin 3 Q9BXY4 Secreted (By similarity). Extracellular (GO:0005576) ,16357527 secreted 85 0 secreted secreted Deuterostomia Deuterostomia Eukaryota RSPO4 HGNC:16175 R-spondin 4 Q2I0M5 Secreted (By similarity). Extracellular (GO:0005576) 16357527 secreted 33 0 secreted secreted Theria Eukaryota Eukaryota RSPRY1 HGNC:29420 ring finger and SPRY domain containing 1 Q96DX4 Secreted (Potential). cytoplasm 31 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota RSRC1 HGNC:24152 arginine/serine-rich coiled-coil 1 Q96IZ7 Nucleus (By similarity). Nucleus speckle (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and cytoplasm (By similarity). nucleus 27 0 nucleus nucleus Amniota Euteleostomi Chordata RSRC2 HGNC:30559 arginine/serine-rich coiled-coil 2 Q7L4I2 Nucleus (GO:0005634) 17203224,17081983 nucleus 26 0 nucleus nucleus Deuterostomia Deuterostomia Metazoa RSRP1 HGNC:25234 arginine/serine-rich protein 1 Q9BUV0 nucleus 18 0 nucleus nucleus Homininae Amniota Euteleostomi RSU1 HGNC:10464 Ras suppressor protein 1 Q15404 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms RTBDN HGNC:30310 retbindin Q9BSG5 Secreted (Potential). secreted 99 0 secreted secreted Eutheria Mammalia Opisthokonta RTCA HGNC:17981 RNA 3'-terminal phosphate cyclase O00442 Nucleus, nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9184239,9184239 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms RTCB HGNC:26935 RNA 2',3'-cyclic phosphate and 5'-OH ligase Q9Y3I0 Cytoplasm (By similarity). cytoplasm 99 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms RTDR1 HGNC:13437 rhabdoid tumor deletion region gene 1 Q9UHP6 cytoplasm 33 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota RTEL1 HGNC:15888 regulator of telomere elongation helicase 1 Q9NZ71 Nucleus (By similarity). Nucleus (GO:0005634) 15210109 nucleus 15 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms RTF1 HGNC:28996 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Q92541 Nucleus, nucleoplasm (By similarity). nucleus 31 0 nucleus nucleus Bilateria Eukaryota Eukaryota RTFDC1 HGNC:15890 replication termination factor 2 domain containing 1 Q9BY42 Nucleolus (GO:0005730) 15635413 nucleus 22 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RTKN HGNC:10466 rhotekin Q9BST9 Cytoplasm (GO:0005737) 10940294 cytoplasm 49 0 cytoplasm cytoplasm Theria Deuterostomia Metazoa RTKN2 HGNC:19364 rhotekin 2 Q8IZC4 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15504364,15504364 cytoplasm 60 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa RTL1 HGNC:14665 retrotransposon-like 1 A6NKG5 Membrane; Multi-pass membrane protein (Potential). nucleus 17 2 nucleus nucleus NA NA Cell.Organisms RTN1 HGNC:10467 reticulon 1 Q16799 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 7844160,7515034,8833145 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Eukaryota Eukaryota RTN2 HGNC:10468 reticulon 2 O75298 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 9693037 endoplasmic reticulum membrane 39 3 endoplasmic reticulum endoplasmic reticulum Theria Theria Metazoa RTN3 HGNC:10469 reticulon 3 O95197 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 12811824,15286784,15286784,17081983 endoplasmic reticulum membrane 38 3 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. nucleus multiple Euteleostomi Eukaryota Eukaryota RTN4 HGNC:14085 reticulon 4 Q9NQC3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Endoplasmic reticulum membrane (GO:0005789); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10667797,10667797,15598749/17081983,17081983 endoplasmic reticulum membrane 100 3 cytoplasm. endoplasmic reticulum membrane. mitochondrion. nucleus. plasma membrane multiple Chordata Eukaryota Metazoa RTN4IP1 HGNC:18647 reticulon 4 interacting protein 1 Q8WWV3 Mitochondrion. Mitochondrion (GO:0005739) 12067236 mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms RTN4R HGNC:18601 reticulon 4 receptor Q9BZR6 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 11201742,15331667,12839991 plasma membrane 17 1 plasma membrane plasma membrane Euarchontoglires Euteleostomi Cell.Organisms RTN4RL1 HGNC:21329 reticulon 4 receptor-like 1 Q86UN2 Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons. Plasma membrane (GO:0005886) 12694398 secreted 17 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms RTN4RL2 HGNC:23053 reticulon 4 receptor-like 2 Q86UN3 Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons. Plasma membrane (GO:0005886) 12839991,12694398 secreted 25 0 secreted secreted Euarchontoglires Euteleostomi Cell.Organisms RTP1 HGNC:28580 receptor (chemosensory) transporter protein 1 P59025 Cell membrane; Single-pass type III membrane protein (By similarity). Note=Effective cell surface expression depends upon interaction with olfactory receptors (By similarity). Plasma membrane (GO:0005886) 15550249 plasma membrane 88 1 plasma membrane plasma membrane Mammalia Mammalia Bilateria RTP2 HGNC:32486 receptor (chemosensory) transporter protein 2 Q5QGT7 Cell membrane; Single-pass type III membrane protein (By similarity). Note=Effective cell surface expression depends upon interaction with olfactory receptors (By similarity). Plasma membrane (GO:0005886) plasma membrane 83 1 plasma membrane plasma membrane Eutheria Eutheria Bilateria RTP3 HGNC:15572 receptor (chemosensory) transporter protein 3 Q9BQQ7 Membrane; Single-pass type III membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 11896456 plasma membrane 24 1 endoplasmic reticulum endoplasmic reticulum Eutheria Euteleostomi Bilateria RTP4 HGNC:23992 receptor (chemosensory) transporter protein 4 Q96DX8 Membrane; Single-pass type III membrane protein (Potential). Plasma membrane (GO:0005886) 15550249 plasma membrane 18 1 plasma membrane plasma membrane Eutheria Chordata Bilateria RTP5 HGNC:26585 receptor (chemosensory) transporter protein 5 (putative) Q14D33 Membrane; Single-pass membrane protein (Potential). plasma membrane 15 1 plasma membrane plasma membrane Human Eutheria Euteleostomi RTTN HGNC:18654 rotatin Q86VV8 Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with the basal bodies at the primary cilium. Nucleus (GO:0005634) 17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Holozoa RUFY1 HGNC:19760 RUN and FYVE domain containing 1 Q96T51 Cytoplasm. Early endosome membrane; Peripheral membrane protein. Endosome (GO:0005768); Plasma membrane (GO:0005886) 11877430,11877430 nucleus 52 0 cytoplasm. endosome multiple Deuterostomia Bilateria Eukaryota RUFY2 HGNC:19761 RUN and FYVE domain containing 2 Q8WXA3 Nucleus (By similarity). nucleus 94 0 nucleus nucleus Deuterostomia Bilateria Eukaryota RUFY3 HGNC:30285 RUN and FYVE domain containing 3 Q7L099 Cell projection (By similarity). Note=Enriched in F-actin enriched filopodia and lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture (By similarity). nucleus 54 0 nucleus nucleus Deuterostomia Bilateria Eukaryota RUFY4 HGNC:24804 RUN and FYVE domain containing 4 Q6ZNE9 cytoplasm 18 0 cytoplasm cytoplasm Theria Amniota Holozoa RUNDC1 HGNC:25418 RUN domain containing 1 Q96C34 cytoplasm 19 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa RUNDC3A HGNC:16984 RUN domain containing 3A Q59EK9 nucleus 10 0 nucleus nucleus Theria Euteleostomi Holozoa RUNDC3B HGNC:30286 RUN domain containing 3B Q96NL0 nucleus 17 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa RUNX1 HGNC:10471 runt-related transcription factor 1 Q01196 Nucleus. Nucleus (GO:0005634) 12356919,17431401,17377532 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Holozoa RUNX1T1 HGNC:1535 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Q06455 Nucleus. Note=Colocalizes with ATN1 in discrete nuclear dots. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8781439,10951564,9632137 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Opisthokonta RUNX2 HGNC:10472 runt-related transcription factor 2 Q13950 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730) 10521292/10330183,12391164,16299379,17251981 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa RUNX3 HGNC:10473 runt-related transcription factor 3 Q13761 Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Nucleus (GO:0005634);Nucleus (GO:0005634) 15138260/12907736 nucleus 62 0 cytoplasm. nucleus multiple Euarchontoglires Euteleostomi Holozoa RUSC1 HGNC:17153 RUN and SH3 domain containing 1 Q9BVN2 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton (By similarity). Cytoplasmic vesicle (By similarity). Early endosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Golgi apparatus (By similarity). Note=Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 15024033,15024033,15024033 cytoplasm 28 0 cytoplasm. nucleus multiple Euarchontoglires Amniota Opisthokonta RUSC2 HGNC:23625 RUN and SH3 domain containing 2 Q8N2Y8 Cytoplasm, cytosol. Note=Cytosolic punctate distribution. Also observed in the perinuclear region. Nucleus (GO:0005634) 17081983 cytoplasm 100 1 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Holozoa RUVBL1 HGNC:10474 RuvB-like AAA ATPase 1 Q9Y265 Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Chromosome (GO:0005694) 9196036,19059367,11027681,15635413,16230350 nucleus 74 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms RUVBL2 HGNC:10475 RuvB-like AAA ATPase 2 Q9Y230 Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694) 10524211,10524211,19059367,15635413,16230350 nucleus 73 0 cytoplasm. nucleus multiple Theria Cell.Organisms Cell.Organisms RWDD1 HGNC:20993 RWD domain containing 1 Q9H446 nucleus 49 0 nucleus nucleus Eukaryota Eukaryota Eukaryota RWDD2A HGNC:21385 RWD domain containing 2A Q9UIY3 cytoplasm 39 0 cytoplasm cytoplasm Tetrapoda Bilateria Eukaryota RWDD2B HGNC:1302 RWD domain containing 2B P57060 cytoplasm 34 0 cytoplasm cytoplasm Human Human Eukaryota RWDD3 HGNC:21393 RWD domain containing 3 Q9Y3V2 Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots. Nucleus (GO:0005634) ,17956732, cytoplasm 51 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Holozoa RWDD4 HGNC:23750 RWD domain containing 4 Q6NW29 nucleus 54 0 nucleus nucleus Euteleostomi Bilateria Eukaryota RXFP1 HGNC:19718 relaxin/insulin-like family peptide receptor 1 Q9HBX9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10935549 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms RXFP2 HGNC:17318 relaxin/insulin-like family peptide receptor 2 Q8WXD0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12114498 plasma membrane 100 8 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms RXFP3 HGNC:24883 relaxin/insulin-like family peptide receptor 3 Q9NSD7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10806363 plasma membrane 100 7 plasma membrane plasma membrane Chordata Chordata Eumetazoa RXFP4 HGNC:14666 relaxin/insulin-like family peptide receptor 4 Q8TDU9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14522967,14530218 plasma membrane 100 7 plasma membrane plasma membrane Catarrhini Theria Eumetazoa RXRA HGNC:10477 retinoid X receptor, alpha P19793 Nucleus. Nucleus (GO:0005634) 1651173 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria NA RXRB HGNC:10478 retinoid X receptor, beta P28702 Nucleus. Nucleus (GO:0005634) 1662118 nucleus 100 0 nucleus nucleus Theria Theria NA RXRG HGNC:10479 retinoid X receptor, gamma P48443 Nucleus (By similarity). Nucleus (GO:0005634) 7806300 nucleus 98 0 nucleus nucleus Deuterostomia Bilateria Metazoa RYBP HGNC:10480 RING1 and YY1 binding protein Q8N488 Nucleus. Cytoplasm. Nucleus, nucleoplasm (By similarity). Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). Nucleus (GO:0005634); Nucleoplasm (GO:0005654) 10369680,17070805 nucleus 62 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa RYK HGNC:10481 receptor-like tyrosine kinase P34925 Membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity). Cytoplasm (By similarity). Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus (By similarity). Integral to membrane (GO:0016021) 11956217,8386829 cytoplasm 19 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms RYR1 HGNC:10483 ryanodine receptor 1 (skeletal) P21817 Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein (Probable). Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. Endoplasmic reticulum (GO:0005783); Sarcoplasmic reticulum (GO:0016529); Nucleus (GO:0005634) 12045220,12709444,11807805,12709444 cytoplasm 18 9 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Bilateria Cell.Organisms Cell.Organisms RYR2 HGNC:10484 ryanodine receptor 2 (cardiac) Q92736 Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein (Probable). Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic (By similarity). Sarcoplasmic reticulum (GO:0016529); Endoplasmic reticulum (GO:0005783) 10830164,15054223,10788707 nucleus 20 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Cell.Organisms Cell.Organisms RYR3 HGNC:10485 ryanodine receptor 3 Q15413 Sarcoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Membrane; Multi-pass membrane protein (Probable). Microsome membrane; Multi-pass membrane protein (By similarity). Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic (By similarity). Sarcoplasmic reticulum (GO:0016529) 9384575 cytoplasm 19 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Cell.Organisms Cell.Organisms S100A1 HGNC:10486 S100 calcium binding protein A1 P23297 Cytoplasm. Cytoplasm (GO:0005737); Sarcoplasmic reticulum (GO:0016529); Nucleus (GO:0005634) 9645951,9645951,9645951 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Theria Euteleostomi Craniata S100A10 HGNC:10487 S100 calcium binding protein A10 P60903 Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9047302,11590242,11590242 cytoplasm 40 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Olfactores S100A11 HGNC:10488 S100 calcium binding protein A11 P31949 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endosome (GO:0005768) 10851017,10851017,12704215,9287141 cytoplasm 29 0 cytoplasm. endosome. nucleus multiple Tetrapoda Tetrapoda Craniata S100A12 HGNC:10489 S100 calcium binding protein A12 P80511 Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway. Cytoplasm (GO:0005737) 7626002 cytoplasm 28 0 cytoplasm. secreted multiple Catarrhini Eutheria Olfactores S100A13 HGNC:10490 S100 calcium binding protein A13 Q99584 Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Perinuclear region (GO:0048471) 12118070,12118070,15635413,10722710 cytoplasm 29 0 cytoplasm. nucleus. secreted multiple Amniota Amniota Craniata S100A14 HGNC:18901 S100 calcium binding protein A14 Q9HCY8 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11944983,12477722 cytoplasm 100 0 cytoplasm cytoplasm Theria Euteleostomi Euteleostomi S100A16 HGNC:20441 S100 calcium binding protein A16 Q96FQ6 Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. Translocates from the nucleolus to the cytoplasm in response to an increase of intracellular calcium levels. Nucleolus (GO:0005730) 15635413 cytoplasm 21 0 cytoplasm. nucleus multiple Theria Theria Craniata S100A2 HGNC:10492 S100 calcium binding protein A2 P29034 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10429967,12445212 cytoplasm 40 0 cytoplasm. nucleus multiple Catarrhini Mammalia Craniata S100A3 HGNC:10493 S100 calcium binding protein A3 P33764 Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Mammalia Mammalia Craniata S100A4 HGNC:10494 S100 calcium binding protein A4 P26447 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 11994292,12756252,15788416,11994292,15635413 cytoplasm 39 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Craniata S100A5 HGNC:10495 S100 calcium binding protein A5 P33763 cytoplasm 34 0 cytoplasm cytoplasm Theria Theria Craniata S100A6 HGNC:10496 S100 calcium binding protein A6 P06703 Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12601007,12601007 cytoplasm 33 0 cytoplasm. nucleus multiple Eutheria Amniota Craniata S100A7 HGNC:10497 S100 calcium binding protein A7 P31151 Cytoplasm. Secreted. Note=Secreted by a non- classical secretory pathway. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12839573,12421467,10191275,10595935,12839573,12704215,12421467,10595935,12704215,12421467 cytoplasm 84 0 cytoplasm. endoplasmic reticulum. nucleus. secreted multiple Catarrhini Eutheria Mammalia S100A7A HGNC:21657 S100 calcium binding protein A7A Q86SG5 Cytoplasm (By similarity). cytoplasm 10 0 cytoplasm cytoplasm Catarrhini Eutheria Mammalia S100A7L2 HGNC:21655 S100 calcium binding protein A7-like 2 Q5SY68 cytoplasm 82 0 cytoplasm cytoplasm Catarrhini Catarrhini Amniota S100A8 HGNC:10498 S100 calcium binding protein A8 P05109 Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12626582,11435486,12626582,1326551,8400238 cytoplasm 26 0 cytoplasm. secreted multiple Mammalia Mammalia Craniata S100A9 HGNC:10499 S100 calcium binding protein A9 P06702 Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12626582,12626582,16188874,10464253,8400238 cytoplasm 24 0 cytoplasm. secreted multiple Theria Amniota Craniata S100B HGNC:10500 S100 calcium binding protein B P04271 Cytoplasm. Nucleus. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12469878,12377780,9925766 cytoplasm 50 0 cytoplasm. nucleus. secreted multiple Amniota Euteleostomi Craniata S100G HGNC:1436 S100 calcium binding protein G P29377 Cytoplasm (GO:0005737) 8308886 cytoplasm 33 0 cytoplasm cytoplasm Theria Theria Eukaryota S100P HGNC:10504 S100 calcium binding protein P P25815 Nucleus. Cytoplasm. Note=Colocalizes with S100PBP in the nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11127925,12808036 cytoplasm 42 0 cytoplasm. nucleus multiple Catarrhini Theria Craniata S100PBP HGNC:25768 S100P binding protein Q96BU1 Nucleus. Note=Colocalizes with S100P in the nucleus. Nucleus (GO:0005634) 15632002 nucleus 100 0 nucleus nucleus Theria Euteleostomi Euteleostomi S100Z HGNC:30367 S100 calcium binding protein Z Q8WXG8 cytoplasm 50 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata S1PR1 HGNC:3165 sphingosine-1-phosphate receptor 1 P21453 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9705355 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa S1PR2 HGNC:3169 sphingosine-1-phosphate receptor 2 O95136 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11331101 plasma membrane 100 7 plasma membrane plasma membrane Eutheria Euteleostomi NA S1PR3 HGNC:3167 sphingosine-1-phosphate receptor 3 Q99500 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12039947,10794715,12039947,10555146 plasma membrane 100 7 cytoplasm. plasma membrane. secreted multiple Theria Euteleostomi Metazoa S1PR4 HGNC:3170 sphingosine-1-phosphate receptor 4 O95977 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10753843 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Eumetazoa S1PR5 HGNC:14299 sphingosine-1-phosphate receptor 5 Q9H228 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11331101 plasma membrane 100 7 plasma membrane plasma membrane Human Theria Eumetazoa SAA1 HGNC:10513 serum amyloid A1 P0DJI8 Secreted. Extracellular (GO:0005576) 9815279,16188874 secreted 100 0 secreted secreted Mammalia Deuterostomia Cell.Organisms SAA2 HGNC:10514 serum amyloid A2 P0DJI9 Secreted. Extracellular (GO:0005576) 3950541,8089807 secreted 100 0 secreted secreted NA NA Cell.Organisms SAA4 HGNC:10516 serum amyloid A4, constitutive P35542 Secreted. Extracellular (GO:0005576) 8159722 secreted 100 0 secreted secreted Human Human Deuterostomia SAAL1 HGNC:25158 serum amyloid A-like 1 Q96ER3 nucleus 49 0 nucleus nucleus Chordata Chordata Eukaryota SAC3D1 HGNC:30179 SAC3 domain containing 1 A6NKF1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Localizes on centrosomes in interphase cells and at spindles in mitosis (By similarity). Centrosome (GO:0005813); Nucleus (GO:0005634) 15322101,17081983 cytoplasm 69 0 nucleus nucleus Theria Opisthokonta Eumetazoa SACM1L HGNC:17059 SAC1 suppressor of actin mutations 1-like (yeast) Q9NTJ5 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 14527956,10887188,14527956 endoplasmic reticulum membrane 94 5 endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota SACS HGNC:10519 sacsin molecular chaperone Q9NZJ4 Cytoplasm. Note=Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60. Nucleus (GO:0005634) 10655055 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms SAE1 HGNC:30660 SUMO1 activating enzyme subunit 1 Q9UBE0 Nucleus. Nucleus (GO:0005634) 10187858 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms SAFB HGNC:10520 scaffold attachment factor B Q15424 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8600450,12660241,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms SAFB2 HGNC:21605 scaffold attachment factor B2 Q14151 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12660241,12660241,17081983 nucleus 65 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms SAG HGNC:10521 S-antigen; retina and pineal gland (arrestin) P10523 Cytoplasm (GO:0005737) 2249983 cytoplasm 38 0 cytoplasm cytoplasm Human Euteleostomi Holozoa SAGE1 HGNC:30369 sarcoma antigen 1 Q9NXZ1 nucleus 27 0 nucleus nucleus Catarrhini Catarrhini NA SALL1 HGNC:10524 spalt-like transcription factor 1 Q9NSC2 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11751684,11751684 nucleus 87 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota SALL2 HGNC:10526 spalt-like transcription factor 2 Q9Y467 Nucleus (Probable). Nucleus (GO:0005634) nucleus 13 1 nucleus nucleus Theria Tetrapoda Eukaryota SALL3 HGNC:10527 spalt-like transcription factor 3 Q9BXA9 Nucleus (Probable). Nucleus (GO:0005634) 10610715 nucleus 44 0 nucleus nucleus NA NA NA SALL4 HGNC:15924 spalt-like transcription factor 4 Q9UJQ4 Cytoplasm. Nucleus. Nucleus (GO:0005634) nucleus 30 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota SAMD1 HGNC:17958 sterile alpha motif domain containing 1 Q6SPF0 Cytoplasm. Secreted. nucleus 32 0 cytoplasm. secreted multiple Chordata Bilateria Metazoa SAMD10 HGNC:16129 sterile alpha motif domain containing 10 Q9BYL1 nucleus 52 0 nucleus nucleus Human Bilateria Bilateria SAMD11 HGNC:28706 sterile alpha motif domain containing 11 Q96NU1 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 67 0 nucleus nucleus Amniota Euteleostomi Eumetazoa SAMD12 HGNC:31750 sterile alpha motif domain containing 12 Q8N8I0 Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Chordata Bilateria Eukaryota SAMD13 HGNC:24582 sterile alpha motif domain containing 13 Q5VXD3 nucleus 33 0 nucleus nucleus Chordata Bilateria Eumetazoa SAMD14 HGNC:27312 sterile alpha motif domain containing 14 Q8IZD0 cytoplasm 18 0 cytoplasm cytoplasm Mammalia Euteleostomi Euteleostomi SAMD15 HGNC:18631 sterile alpha motif domain containing 15 Q9P1V8 endoplasmic reticulum 19 0 endoplasmic reticulum endoplasmic reticulum Amniota Bilateria Opisthokonta SAMD3 HGNC:21574 sterile alpha motif domain containing 3 Q8N6K7 nucleus 41 0 nucleus nucleus Mammalia Deuterostomia Holozoa SAMD4A HGNC:23023 sterile alpha motif domain containing 4A Q9UPU9 Cytoplasm. Cell projection, dendrite (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. cytoplasm 28 0 cytoplasm cytoplasm Chordata Chordata Opisthokonta SAMD4B HGNC:25492 sterile alpha motif domain containing 4B Q5PRF9 Cytoplasm. Nucleus. cytoplasm 31 0 cytoplasm. nucleus multiple Chordata Chordata Opisthokonta SAMD5 HGNC:21180 sterile alpha motif domain containing 5 Q5TGI4 plasma membrane 23 0 n/a n/a Amniota Bilateria Holozoa SAMD7 HGNC:25394 sterile alpha motif domain containing 7 Q7Z3H4 nucleus 40 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa SAMD8 HGNC:26320 sterile alpha motif domain containing 8 Q96LT4 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Cell.Organisms SAMD9 HGNC:1348 sterile alpha motif domain containing 9 Q5K651 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eumetazoa SAMD9L HGNC:1349 sterile alpha motif domain containing 9-like Q8IVG5 Nucleus (GO:0005634) 17081983 cytoplasm 52 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms SAMHD1 HGNC:15925 SAM domain and HD domain 1 Q9Y3Z3 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms SAMM50 HGNC:24276 SAMM50 sorting and assembly machinery component Q9Y512 Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm (By similarity). Mitochondrion (GO:0005739) 17510655 mitochondrion 15 0 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms SAMSN1 HGNC:10528 SAM domain, SH3 domain and nuclear localization signals 1 Q9NSI8 Nucleus. Cytoplasm (By similarity). Cell projection, ruffle (By similarity). Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11536050,11536050,15381729 nucleus 45 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota SAP130 HGNC:29813 Sin3A-associated protein, 130kDa Q9H0E3 Nucleus. Nucleus (GO:0005634) 12724404,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa SAP18 HGNC:10530 Sin3A-associated protein, 18kDa O00422 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,14611647,11960000,,15635413 nucleus 49 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SAP25 HGNC:41908 Sin3A-associated protein, 25kDa Q8TEE9 Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and the cytoplasm (By similarity). nucleus 49 0 nucleus nucleus Homininae Eutheria Eutheria SAP30 HGNC:10532 Sin3A-associated protein, 30kDa O75446 Nucleus. Nucleus (GO:0005634) ,12788099,17081983,11013263, nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota SAP30BP HGNC:30785 SAP30 binding protein Q9UHR5 Nucleus. Nucleus (GO:0005634) 15496587 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SAP30L HGNC:25663 SAP30-like Q9HAJ7 Nucleus, nucleolus. Nucleus (GO:0005634) 14680513,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SAPCD1 HGNC:13938 suppressor APC domain containing 1 Q5SSQ6 nucleus 39 0 nucleus nucleus NA NA NA SAPCD2 HGNC:28055 suppressor APC domain containing 2 Q86UD0 Cytoplasm. Nucleus. nucleus 60 0 cytoplasm. nucleus multiple Theria Bilateria Eumetazoa SAR1A HGNC:10534 secretion associated, Ras related GTPase 1A Q9NR31 Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Endoplasmic reticulum (GO:0005783) 12692552 cytoplasm 17 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota SAR1B HGNC:10535 secretion associated, Ras related GTPase 1B Q9Y6B6 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity). Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12692552,12692552 cytoplasm 16 0 endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota SARDH HGNC:10536 sarcosine dehydrogenase Q9UL12 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739) 10444331,9839943 mitochondrion 86 0 mitochondrion mitochondrion Chordata Cell.Organisms Cell.Organisms SARM1 HGNC:17074 sterile alpha and TIR motif containing 1 Q6SZW1 Cytoplasm. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Mitochondrion. Note=Associated with microtubules (By similarity). Integral to membrane (GO:0016021) 15893701 cytoplasm 27 0 cytoplasm. mitochondrion multiple Bilateria Bilateria NA SARNP HGNC:24432 SAP domain containing ribonucleoprotein P82979 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11356193,11922608,15338056,15048984,15284855,11922608,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Opisthokonta Metazoa SARS HGNC:10537 seryl-tRNA synthetase P49591 Cytoplasm. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11577083,11317363,9431993 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms SARS2 HGNC:17697 seryl-tRNA synthetase 2, mitochondrial Q9NP81 Mitochondrion matrix (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10764807,15081407,10764807 mitochondrion 84 0 cytoplasm. mitochondrion multiple NA NA Cell.Organisms SART1 HGNC:10538 squamous cell carcinoma antigen recognized by T cells O43290 Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9449708,17000644,15561729,9449708 nucleus 100 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota SART3 HGNC:16860 squamous cell carcinoma antigen recognized by T cells 3 Q15020 Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (S), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11477570,10463607,17081983 nucleus 13 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms SASH1 HGNC:19182 SAM and SH3 domain containing 1 O94885 Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Amniota Euteleostomi Metazoa SASH3 HGNC:15975 SAM and SH3 domain containing 3 O75995 cytoplasm 50 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta SASS6 HGNC:25403 spindle assembly 6 homolog (C. elegans) Q6UVJ0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota SAT1 HGNC:10540 spermidine/spermine N1-acetyltransferase 1 P21673 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 8033120,11779193 cytoplasm 100 0 cytoplasm. mitochondrion multiple Euteleostomi Cell.Organisms Cell.Organisms SAT2 HGNC:23160 spermidine/spermine N1-acetyltransferase family member 2 Q96F10 Cytoplasm. Note=Intracellular organelles. cytoplasm 100 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms SATB1 HGNC:10541 SATB homeobox 1 Q01826 Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs). Nucleus (GO:0005634); Mitochondrion (GO:0005739) 9886398,15598749 nucleus 100 0 mitochondrion. nucleus multiple Euteleostomi Euteleostomi Bilateria SATB2 HGNC:21637 SATB homeobox 2 Q9UPW6 Nucleus matrix. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14701874,14701874 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Bilateria SATL1 HGNC:27992 spermidine/spermine N1-acetyl transferase-like 1 Q86VE3 cytoplasm 50 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms SAV1 HGNC:17795 salvador homolog 1 (Drosophila) Q9H4B6 Nucleus. Cytoplasm. Nucleus (GO:0005634) 11027580 cytoplasm 40 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota SAYSD1 HGNC:21025 SAYSVFN motif domain containing 1 Q9NPB0 Cytoplasmic vesicle membrane; Single-pass membrane protein. endoplasmic reticulum membrane 43 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Metazoa SBDS HGNC:19440 Shwachman-Bodian-Diamond syndrome Q9Y3A5 Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). Nucleolus (GO:0005730) 15635413 cytoplasm 21 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms SBF1 HGNC:10542 SET binding factor 1 O95248 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11686296,11686296 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SBF2 HGNC:2135 SET binding factor 2 Q86WG5 Cytoplasm. Membrane; Peripheral membrane protein. Note=Associated with membranes. Cytoplasm (GO:0005737) nucleus 50 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota SBK1 HGNC:17699 SH3 domain binding kinase 1 Q52WX2 Cytoplasm (By similarity). Cytosol (GO:0005829) 11322885 cytoplasm 93 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms SBK2 HGNC:34416 SH3 domain binding kinase family, member 2 P0C263 cytoplasm 24 2 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms SBK3 HGNC:44121 SH3 domain binding kinase family, member 3 P0C264 cytoplasm 20 0 cytoplasm cytoplasm NA NA Cell.Organisms SBNO1 HGNC:22973 strawberry notch homolog 1 (Drosophila) A3KN83 nucleus 53 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms SBNO2 HGNC:29158 strawberry notch homolog 2 (Drosophila) Q9Y2G9 nucleus 38 1 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms SBSN HGNC:24950 suprabasin Q6UWP8 Secreted (By similarity). secreted 44 0 secreted secreted Mammalia Mammalia Bilateria SBSPON HGNC:30362 somatomedin B and thrombospondin, type 1 domain containing Q8IVN8 Secreted, extracellular space, extracellular matrix. secreted 100 0 secreted secreted Bilateria Bilateria Eukaryota SC5D HGNC:10547 sterol-C5-desaturase O75845 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Microsome (GO:0005792); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 7961720,8466936,7560069,7770068 endoplasmic reticulum membrane 17 5 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SCAF1 HGNC:30403 SR-related CTD-associated factor 1 Q9H7N4 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11461075,17081983,17081983 nucleus 54 0 cytoplasm. nucleus multiple Theria Euteleostomi Eumetazoa SCAF11 HGNC:10784 SR-related CTD-associated factor 11 Q99590 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9447963,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota SCAF4 HGNC:19304 SR-related CTD-associated factor 4 O95104 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 49 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SCAF8 HGNC:20959 SR-related CTD-associated factor 8 Q9UPN6 Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription (By similarity). Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota SCAI HGNC:26709 suppressor of cancer cell invasion Q8N9R8 Membrane; Single-pass membrane protein (Potential). Nucleus. Cytoplasm. Note=Nuclear localization is required for inhibition of MKL1 (By similarity). nucleus 45 1 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota SCAMP1 HGNC:10563 secretory carrier membrane protein 1 O15126 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Secretory granule (GO:0030141); Synaptic vesicle (GO:0008021) 10777571,10777571,12475951,8404846,11042173,12124380,11050114 mitochondrion membrane 51 4 cytoplasm. endosome. golgi apparatus. golgi apparatus membrane. plasma membrane multiple Bilateria Eukaryota NA SCAMP2 HGNC:10564 secretory carrier membrane protein 2 O15127 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 12475951,12124380,12475951,12124380 mitochondrion membrane 54 4 cytoplasm. endosome. golgi apparatus membrane. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota SCAMP3 HGNC:10565 secretory carrier membrane protein 3 O14828 Membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Early endosome (GO:0005769);Nucleus (GO:0005634) 9378760,10777571,10777571,,19158374,/17081983 mitochondrion membrane 62 4 cytoplasm. endosome. golgi apparatus. nucleus. plasma membrane multiple Theria Euteleostomi NA SCAMP4 HGNC:30385 secretory carrier membrane protein 4 Q969E2 Membrane; Multi-pass membrane protein. Cytoplasmic vesicle (GO:0016023) 11050114,11295240 mitochondrion membrane 45 4 mitochondrion membrane mitochondrion membrane NA NA Eukaryota SCAMP5 HGNC:30386 secretory carrier membrane protein 5 Q8TAC9 Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). Cytoplasmic vesicle (GO:0016023) 11050114 mitochondrion membrane 65 4 endosome. golgi apparatus membrane. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota SCAND1 HGNC:10566 SCAN domain containing 1 P57086 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12383503,12383503 nucleus 38 0 cytoplasm. nucleus multiple Theria Theria Craniata SCAND3 HGNC:13851 SCAN domain containing 3 Q6R2W3 Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus NA NA NA SCAP HGNC:30634 SREBF chaperone Q12770 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi- pass membrane protein (By similarity). Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein (By similarity). Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 10896675,9642295,10896675,9642295,9242699,17081983 nucleus 10 10 endoplasmic reticulum. golgi apparatus. nucleus multiple Chordata Bilateria Cell.Organisms SCAPER HGNC:13081 S-phase cyclin A-associated protein in the ER Q9BY12 Endoplasmic reticulum. Nucleus. Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus. Nucleus (GO:0005634) cytoplasm 18 3 endoplasmic reticulum. nucleus multiple Deuterostomia Bilateria Eukaryota SCARA3 HGNC:19000 scavenger receptor class A, member 3 Q6AZY7 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nuclear membrane (GO:0005635) 9580669,9580669,9580669,9580669 secreted 36 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. nucleus membrane multiple Euteleostomi Euteleostomi Craniata SCARA5 HGNC:28701 scavenger receptor class A, member 5 (putative) Q6ZMJ2 Cell membrane; Single-pass type II membrane protein (By similarity). plasma membrane 86 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa SCARB1 HGNC:1664 scavenger receptor class B, member 1 Q8WTV0 Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11575708,11196441 plasma membrane 15 2 plasma membrane. secreted multiple Euteleostomi Euteleostomi Eukaryota SCARB2 HGNC:1665 scavenger receptor class B, member 2 Q14108 Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7539776 plasma membrane 17 2 lysosome membrane. plasma membrane multiple Bilateria Bilateria Eukaryota SCARF1 HGNC:16820 scavenger receptor class F, member 1 Q14162 Membrane; Single-pass type I membrane protein (Potential). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11978792,11978792 plasma membrane 32 1 plasma membrane. secreted multiple Amniota Euteleostomi Eukaryota SCARF2 HGNC:19869 scavenger receptor class F, member 2 Q96GP6 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 12154095 plasma membrane 22 1 plasma membrane plasma membrane NA NA Eukaryota SCCPDH HGNC:24275 saccharopine dehydrogenase (putative) Q8NBX0 Mitochondrion (GO:0005739) 15598749 cytoplasm 33 1 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms SCD HGNC:10571 stearoyl-CoA desaturase (delta-9-desaturase) O00767 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 10922050,9362069,21148 endoplasmic reticulum membrane 80 6 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SCD5 HGNC:21088 stearoyl-CoA desaturase 5 Q86SK9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 15907797,12815040 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Cell.Organisms Cell.Organisms SCEL HGNC:10573 sciellin O95171 Cytoplasm. Membrane. Note=May become cross- linked to membrane proteins by transglutaminase. Cytoplasm (GO:0005737) 9813070 nucleus 77 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria SCFD1 HGNC:20726 sec1 family domain containing 1 Q8WVM8 Cytoplasm (By similarity). Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 9195952,9195952,17081983 cytoplasm 25 0 golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota SCFD2 HGNC:30676 sec1 family domain containing 2 Q8WU76 cytoplasm 53 1 cytoplasm cytoplasm Deuterostomia Eukaryota Opisthokonta SCG2 HGNC:10575 secretogranin II P13521 Secreted. Note=Neuroendocrine and endocrine secretory granules. Golgi apparatus (GO:0005794) 1425774 secreted 100 0 golgi apparatus. secreted multiple Euteleostomi Euteleostomi Craniata SCG3 HGNC:13707 secretogranin III Q8WXD2 Cytoplasmic vesicle, secretory vesicle lumen (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By similarity). Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules. Secretory granule (GO:0030141); Golgi apparatus (GO:0005794); Extracellular (GO:0005576) 14597614,12388744,12533531,15125023,12098761,12098761 nucleus 58 0 golgi apparatus. secreted multiple Euteleostomi Euteleostomi Chordata SCG5 HGNC:10816 secretogranin V (7B2 protein) P05408 Secreted. Note=Neuroendocrine and endocrine secretory granules. Extracellular (GO:0005576) 3134253 secreted 100 0 secreted secreted Euteleostomi Bilateria Bilateria SCGB1A1 HGNC:12523 secretoglobin, family 1A, member 1 (uteroglobin) P11684 Secreted. Extracellular (GO:0005576) 11193760 secreted 100 0 secreted secreted Eutheria Mammalia Eutheria SCGB1C1 HGNC:18394 secretoglobin, family 1C, member 1 Q8TD33 Secreted (By similarity). secreted 22 0 secreted secreted NA NA Amniota SCGB1D1 HGNC:18395 secretoglobin, family 1D, member 1 O95968 Secreted (Potential). Extracellular (GO:0005576) 9720917,10066439 secreted 40 0 secreted secreted Catarrhini Catarrhini Eutheria SCGB1D2 HGNC:18396 secretoglobin, family 1D, member 2 O95969 Secreted (Potential). Extracellular (GO:0005576) 12576445 secreted 45 0 secreted secreted Euarchontoglires Mammalia Eutheria SCGB1D4 HGNC:31748 secretoglobin, family 1D, member 4 Q6XE38 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Homininae Homininae Eutheria SCGB2A1 HGNC:7051 secretoglobin, family 2A, member 1 O75556 Extracellular (GO:0005576) 12826312 secreted 20 0 secreted secreted Euarchontoglires Eutheria Eutheria SCGB2A2 HGNC:7050 secretoglobin, family 2A, member 2 Q13296 Extracellular (GO:0005576) 9488047 secreted 29 0 secreted secreted Euarchontoglires Eutheria Eutheria SCGB2B2 HGNC:27616 secretoglobin, family 2B, member 2 Q4G0G5 Secreted (Potential). secreted 83 0 secreted secreted Homininae Homininae Primates SCGB3A1 HGNC:18384 secretoglobin, family 3A, member 1 Q96QR1 Secreted. Extracellular (GO:0005576) 11481438,12847263 secreted 100 0 secreted secreted Euarchontoglires Theria Homo SCGB3A2 HGNC:18391 secretoglobin, family 3A, member 2 Q96PL1 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Mammalia Mammalia Mammalia SCGN HGNC:16941 secretagogin, EF-hand calcium binding protein O76038 Cytoplasm. Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10811645,10811645,10811645 mitochondrion membrane 21 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms SCHIP1 HGNC:15678 schwannomin interacting protein 1 Q9P0W5 Cytoplasm. Note=Partially colocalizes with NF2 beneath the cytoplasmic membrane. Cytoplasm (GO:0005737) 10669747 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Bilateria SCIMP HGNC:33504 SLP adaptor and CSK interacting membrane protein Q6UWF3 Membrane; Single-pass membrane protein (Potential). Membrane; Lipid-anchor. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin- enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen- presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell- cell contacts but also at the leading edge of migrating cells. Integral to membrane (GO:0016021) nucleus 9 1 nucleus nucleus Theria Theria Mammalia SCIN HGNC:21695 scinderin Q9Y6U3 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 15342343,15342343 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota SCLT1 HGNC:26406 sodium channel and clathrin linker 1 Q96NL6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Golgi apparatus (GO:0005794); Lysosome (GO:0005764) 15797711,15797711 cytoplasm 100 0 cytoplasm. golgi apparatus. lysosome multiple Deuterostomia Deuterostomia Metazoa SCLY HGNC:18161 selenocysteine lyase Q96I15 Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737) 10692412 cytoplasm 76 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms SCMH1 HGNC:19003 sex comb on midleg homolog 1 (Drosophila) Q96GD3 Nucleus (Probable). Nucleus (GO:0005634) 10524249 nucleus 36 0 nucleus nucleus Deuterostomia Deuterostomia Holozoa SCML1 HGNC:10580 sex comb on midleg-like 1 (Drosophila) Q9UN30 Nucleus (Probable). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Catarrhini Eutheria Opisthokonta SCML2 HGNC:10581 sex comb on midleg-like 2 (Drosophila) Q9UQR0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Deuterostomia Deuterostomia Holozoa SCML4 HGNC:21397 sex comb on midleg-like 4 (Drosophila) Q8N228 Nucleus (Probable). nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa SCN10A HGNC:10582 sodium channel, voltage-gated, type X, alpha subunit Q9Y5Y9 Membrane; Multi-pass membrane protein (By similarity). Note=It can be translocated to the extracellular membrane through association with S100A10 (By similarity). Plasma membrane (GO:0005886) 9839820 vacuole membrane 9 22 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN11A HGNC:10583 sodium channel, voltage-gated, type XI, alpha subunit Q9UI33 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10623608 vacuole membrane 11 22 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN1A HGNC:10585 sodium channel, voltage-gated, type I, alpha subunit P35498 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11295230 vacuole membrane 10 22 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN1B HGNC:10586 sodium channel, voltage-gated, type I, beta subunit Q07699 Membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886) 11744748 plasma membrane 13 1 plasma membrane. secreted multiple Theria Euteleostomi Craniata SCN2A HGNC:10588 sodium channel, voltage-gated, type II, alpha subunit Q99250 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1325650 vacuole membrane 10 22 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN2B HGNC:10589 sodium channel, voltage-gated, type II, beta subunit O60939 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8521473 plasma membrane 14 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata SCN3A HGNC:10590 sodium channel, voltage-gated, type III, alpha subunit Q9NY46 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9589372 vacuole membrane 10 24 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN3B HGNC:20665 sodium channel, voltage-gated, type III, beta subunit Q9NY72 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata SCN4A HGNC:10591 sodium channel, voltage-gated, type IV, alpha subunit P35499 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1659948,10366610 plasma membrane 14 22 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN4B HGNC:10592 sodium channel, voltage-gated, type IV, beta subunit Q8IWT1 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 1293796 plasma membrane 19 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi SCN5A HGNC:10593 sodium channel, voltage-gated, type V, alpha subunit Q14524 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytosol (GO:0005829) 15579534,1309946,16115203,15217910,15217910 plasma membrane 13 24 cytoplasm. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms SCN7A HGNC:10594 sodium channel, voltage-gated, type VII, alpha subunit Q01118 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) vacuole membrane 12 24 vacuole membrane vacuole membrane Deuterostomia Eukaryota Cell.Organisms SCN8A HGNC:10596 sodium channel, voltage gated, type VIII, alpha subunit Q9UQD0 Membrane; Multi-pass membrane protein. Isoform 5: Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane. Plasma membrane (GO:0005886) 10779552 vacuole membrane 9 22 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SCN9A HGNC:10597 sodium channel, voltage-gated, type IX, alpha subunit Q15858 Membrane; Multi-pass membrane protein. Note=In neurite terminals (By similarity). vacuole membrane 10 24 vacuole membrane vacuole membrane Deuterostomia Eukaryota Cell.Organisms SCNM1 HGNC:23136 sodium channel modifier 1 Q9BWG6 Nucleus (By similarity). Nucleus speckle (By similarity). Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles (By similarity). Nucleus (GO:0005634) 12920299 nucleus 79 0 nucleus nucleus Theria Eukaryota Eukaryota SCNN1A HGNC:10599 sodium channel, non-voltage-gated 1 alpha subunit P37088 Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells. Plasma membrane (GO:0005886) 10642508 plasma membrane 100 2 plasma membrane plasma membrane Tetrapoda Tetrapoda Metazoa SCNN1B HGNC:10600 sodium channel, non-voltage-gated 1, beta subunit P51168 Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells. Plasma membrane (GO:0005886) 8521520 plasma membrane 100 2 plasma membrane plasma membrane Tetrapoda Deuterostomia Metazoa SCNN1D HGNC:10601 sodium channel, non-voltage-gated 1, delta subunit P51172 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7499195 plasma membrane 100 2 plasma membrane plasma membrane Tetrapoda Tetrapoda Metazoa SCNN1G HGNC:10602 sodium channel, non-voltage-gated 1, gamma subunit P51170 Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells. Plasma membrane (GO:0005886); Cell surface (GO:0009986);Cell surface (GO:0009986) 9351815,11845306,,18322022,/,18322022, plasma membrane 100 2 plasma membrane plasma membrane Tetrapoda Bilateria Metazoa SCO1 HGNC:10603 SCO1 cytochrome c oxidase assembly protein O75880 Mitochondrion. Mitochondrion (GO:0005739) 9878253,15598749 mitochondrion 100 1 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SCO2 HGNC:10604 SCO2 cytochrome c oxidase assembly protein O43819 Mitochondrion. Mitochondrion (GO:0005739) 10545952 mitochondrion 100 1 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SCOC HGNC:20335 short coiled-coil protein Q9UIL1 Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 11303027,11303027 nucleus 66 0 cytoplasm. golgi apparatus multiple Euteleostomi Bilateria Opisthokonta SCP2 HGNC:10606 sterol carrier protein 2 P22307 Cytoplasm. Mitochondrion. Isoform SCPx: Peroxisome. Isoform SCP2: Mitochondrion (Probable). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Peroxisome (GO:0005777); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Microsome (GO:0005792); Lysosome (GO:0005764); Soluble fraction (GO:0005625) 8640304,11591437,8640304,11591437,11591437,1703300,12641450,11591437,10567245,10567245,11591437,12641450,11591437,11591437 peroxisome 27 0 cytoplasm. endoplasmic reticulum. lysosome. mitochondrion. peroxisome multiple Human Cell.Organisms Cell.Organisms SCP2D1 HGNC:16211 SCP2 sterol-binding domain containing 1 Q9UJQ7 peroxisome 34 0 peroxisome peroxisome Mammalia Mammalia Cell.Organisms SCPEP1 HGNC:29507 serine carboxypeptidase 1 Q9HB40 Secreted (Potential). Cytoplasm (GO:0005737); Extracellular (GO:0005576) 11447226,11447226 golgi apparatus membrane 12 0 cytoplasm. secreted multiple Bilateria Eukaryota Cell.Organisms SCRG1 HGNC:17036 stimulator of chondrogenesis 1 O75711 Secreted (Probable). Extracellular (GO:0005576) 9660755,16199891 secreted 78 0 secreted secreted Tetrapoda Tetrapoda Craniata SCRIB HGNC:30377 scribbled planar cell polarity protein Q14160 Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre- synaptic regions. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Synapse (GO:0045202); Basolateral membrane (GO:0016323); Cell junction (GO:0030054) 11027293,14681682,15182672,18793635,11027293,18793635,15182672,16103886,15975580,18793635 nucleus 19 0 cytoplasm cytoplasm Bilateria Bilateria NA SCRN1 HGNC:22192 secernin 1 Q12765 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12221138 cytoplasm 88 0 cytoplasm cytoplasm Tetrapoda Bilateria Cell.Organisms SCRN2 HGNC:30381 secernin 2 Q96FV2 Cytoplasm (GO:0005737) 12221138 cytoplasm 41 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms SCRN3 HGNC:30382 secernin 3 Q0VDG4 cytoplasm 44 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms SCRT1 HGNC:15950 scratch family zinc finger 1 Q9BWW7 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11274425,11274425 nucleus 100 0 cytoplasm. nucleus multiple Theria Bilateria NA SCRT2 HGNC:15952 scratch family zinc finger 2 Q9NQ03 Nucleus (Potential). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Theria Bilateria Eukaryota SCT HGNC:10607 secretin P09683 Secreted. Extracellular (GO:0005576) 11060443 secreted 100 0 secreted secreted Homininae Euarchontoglires Boreoeutheria SCTR HGNC:10608 secretin receptor P47872 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11517171,11517171 plasma membrane 100 7 cytoplasm. plasma membrane multiple Theria Amniota Holozoa SCUBE1 HGNC:13441 signal peptide, CUB domain, EGF-like 1 Q8IWY4 Secreted. Cell membrane; Peripheral membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12270931,12270931,12270931 secreted 60 0 cytoplasm. secreted multiple Deuterostomia Deuterostomia Cell.Organisms SCUBE2 HGNC:30425 signal peptide, CUB domain, EGF-like 2 Q9NQ36 Secreted (By similarity). Extracellular (GO:0005576) secreted 62 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms SCUBE3 HGNC:13655 signal peptide, CUB domain, EGF-like 3 Q8IX30 Secreted. Cell surface. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 15234972,15234972 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms SCXA HGNC:24312 scleraxis homolog A (mouse) Q7RTU7 Nucleus (By similarity). nucleus 41 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa SCXB HGNC:32322 scleraxis homolog B (mouse) Q7RTU7 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa SCYL1 HGNC:14372 SCY1-like 1 (S. cerevisiae) Q96KG9 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Isoform 1: Cytoplasm. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Isoform 6: Nucleus. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 12036289,12036289 cytoplasm 11 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms SCYL2 HGNC:19286 SCY1-like 2 (S. cerevisiae) Q6P3W7 Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=According to PubMed:15809293, plasma membrane-associated in clathrin-coated vesicles. According to PubMed:16914521, colocalizes to the trans- Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Clathrin-coated vesicle (GO:0030136); Golgi vesicle (GO:0005798) 16914521,16914521,16914521,16914521 cytoplasm 11 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota Cell.Organisms SCYL3 HGNC:19285 SCY1-like 3 (S. cerevisiae) Q8IZE3 Cytoplasm. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with EZR/VIL2, actin and CD44 in lamellipodia. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 12651155,12651155 cytoplasm 6 1 cytoplasm. golgi apparatus. plasma membrane multiple Deuterostomia Bilateria Eukaryota SDAD1 HGNC:25537 SDA1 domain containing 1 Q9NVU7 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15635413,11790298,17081983,19059367,17081983 nucleus 100 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SDC1 HGNC:10658 syndecan 1 P18827 Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form. Plasma membrane (GO:0005886) 12904296 plasma membrane 80 1 plasma membrane. secreted multiple Amniota Amniota Bilateria SDC2 HGNC:10659 syndecan 2 P34741 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10734053 plasma membrane 57 1 plasma membrane plasma membrane Amniota Euteleostomi Bilateria SDC3 HGNC:10660 syndecan 3 O75056 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11527150 plasma membrane 19 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Euteleostomi SDC4 HGNC:10661 syndecan 4 P31431 Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Isoform 2: Secreted. Plasma membrane (GO:0005886) 1500433,14670076 plasma membrane 42 1 plasma membrane. secreted multiple Euteleostomi Deuterostomia Eumetazoa SDCBP HGNC:10662 syndecan binding protein (syntenin) O00560 Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886); Cytosol (GO:0005829); Nucleus (GO:0005634); Microsome (GO:0005792); Cell junction (GO:0030054); Intracellular vesicle (None); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Synaptic vesicle (GO:0008021); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794);Plasma membrane (GO:0005886); Cytosol (GO:0005829); Microsome (GO:0005792); Cell junction (GO:0030054); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Intracellular vesicle (None) 11179419,11432873,11179419,15254681,11179419,11179419,11179419,11432873,9391086,11432873,9391086/11498591,15276154,12086619,12086619,10230395,10230395/11179419,11432873,9391086,11179419,11432873,15254681,11179419,11179419,11179419,9391086,11432873,9391086 nucleus 14 1 cytoplasm. endoplasmic reticulum. golgi apparatus. melanosome. nucleus. plasma membrane multiple Deuterostomia Bilateria Cell.Organisms SDCBP2 HGNC:15756 syndecan binding protein (syntenin) 2 Q9H190 Cytoplasm (GO:0005737) 11152476 cytoplasm 12 1 cytoplasm cytoplasm Theria Theria Holozoa SDCCAG3 HGNC:10667 serologically defined colon cancer antigen 3 Q96C92 Cytoplasm (By similarity). cytoplasm 77 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota SDCCAG8 HGNC:10671 serologically defined colon cancer antigen 8 Q86SQ7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell junction. Isoform 2: Cytoplasm. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 12559564,12559564 cytoplasm 12 0 cytoplasm cytoplasm Tetrapoda Bilateria Opisthokonta SDE2 HGNC:26643 SDE2 telomere maintenance homolog (S. pombe) Q6IQ49 Nucleus (GO:0005634) 17081983 nucleus 50 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SDF2 HGNC:10675 stromal cell-derived factor 2 Q99470 Secreted (Probable). Extracellular (GO:0005576) 8918255 secreted 94 0 secreted secreted Bilateria Eukaryota Eukaryota SDF2L1 HGNC:10676 stromal cell-derived factor 2-like 1 Q9HCN8 Endoplasmic reticulum lumen (Potential). Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 11162531,15598749 secreted 58 0 endoplasmic reticulum. mitochondrion multiple Bilateria Eukaryota Eukaryota SDF4 HGNC:24188 stromal cell derived factor 4 Q9BRK5 Isoform 1: Golgi apparatus lumen (By similarity). Isoform 5: Cytoplasm. Cell projection, bleb. Note=Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs. Golgi lumen (GO:0005796) 8609160,9254016,10648803 golgi apparatus 84 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Eukaryota SDHA HGNC:10680 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) P31040 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739); Cytosol (GO:0005829) 7798181,15598749,15561729 mitochondrion 22 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms SDHAF1 HGNC:33867 succinate dehydrogenase complex assembly factor 1 A6NFY7 Mitochondrion matrix (Probable). mitochondrion 31 0 mitochondrion mitochondrion Mammalia Eukaryota Eumetazoa SDHAF2 HGNC:26034 succinate dehydrogenase complex assembly factor 2 Q9NX18 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Eukaryota Cell.Organisms SDHB HGNC:10681 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) P21912 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 11404820,15598749 mitochondrion 40 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SDHC HGNC:10682 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa Q99643 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrial membrane (GO:0005740) 9714607,11062460 mitochondrion membrane 100 3 mitochondrion membrane mitochondrion membrane Opisthokonta Cell.Organisms Cell.Organisms SDHD HGNC:10683 succinate dehydrogenase complex, subunit D, integral membrane protein O14521 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9533030 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Opisthokonta Opisthokonta Opisthokonta SDIM1 HGNC:38749 stress responsive DNAJB4 interacting membrane protein 1 Q6ZPB5 Membrane; Multi-pass membrane protein (Potential). secreted 49 2 n/a n/a NA NA Homo SDK1 HGNC:19307 sidekick cell adhesion molecule 1 Q7Z5N4 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) cytoplasm 17 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms SDK2 HGNC:19308 sidekick cell adhesion molecule 2 Q58EX2 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 12230981 secreted 13 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms SDPR HGNC:10690 serum deprivation response O95810 Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 2390065,9566962,9566962 cytoplasm 26 0 cytoplasm. golgi apparatus multiple Theria Euteleostomi Craniata SDR16C5 HGNC:30311 short chain dehydrogenase/reductase family 16C, member 5 Q8N3Y7 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 20 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Cell.Organisms Cell.Organisms SDR39U1 HGNC:20275 short chain dehydrogenase/reductase family 39U, member 1 Q9NRG7 cytoplasm 23 0 cytoplasm cytoplasm Theria Cell.Organisms Cell.Organisms SDR42E1 HGNC:29834 short chain dehydrogenase/reductase family 42E, member 1 Q8WUS8 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 18 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms SDR42E2 HGNC:35414 short chain dehydrogenase/reductase family 42E, member 2 A6NKP2 endoplasmic reticulum membrane 16 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Cell.Organisms Cell.Organisms SDR9C7 HGNC:29958 short chain dehydrogenase/reductase family 9C, member 7 Q8NEX9 Cytoplasm. Note=Granular distribution in the whole cell. cytoplasm 100 1 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SDS HGNC:10691 serine dehydratase P20132 Cytoplasm. Cytoplasm (GO:0005737) 163697,163593 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms SDSL HGNC:30404 serine dehydratase-like Q96GA7 cytoplasm 53 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms SEBOX HGNC:32942 SEBOX homeobox Q9HB31 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 27 0 nucleus nucleus Chordata Chordata NA SEC11A HGNC:17718 SEC11 homolog A (S. cerevisiae) P67812 Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). endoplasmic reticulum membrane 35 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms SEC11C HGNC:23400 SEC11 homolog C (S. cerevisiae) Q9BY50 Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Microsome (GO:0005792) endoplasmic reticulum membrane 36 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms SEC13 HGNC:10697 SEC13 homolog (S. cerevisiae) P55735 Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nuclear membrane (GO:0005635) 14517296,7876304,14517296,7876304,14517296,7876304,15561729 nucleus 18 0 cytoplasm. endoplasmic reticulum. nucleus. nucleus membrane multiple Eukaryota Eukaryota Cell.Organisms SEC14L1 HGNC:10698 SEC14-like 1 (S. cerevisiae) Q92503 Golgi apparatus (GO:0005794) mitochondrion 39 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota SEC14L2 HGNC:10699 SEC14-like 2 (S. cerevisiae) O76054 Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11444841,11444841 cytoplasm 16 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SEC14L3 HGNC:18655 SEC14-like 3 (S. cerevisiae) Q9UDX4 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12757856,12757856,12757856 mitochondrion 14 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota SEC14L4 HGNC:20627 SEC14-like 4 (S. cerevisiae) Q9UDX3 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12757856,12757856,12757856 mitochondrion 15 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota SEC14L5 HGNC:29032 SEC14-like 5 (S. cerevisiae) O43304 mitochondrion 37 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota SEC14L6 HGNC:40047 SEC14-like 6 (S. cerevisiae) B5MCN3 mitochondrion 16 0 mitochondrion mitochondrion NA NA Eukaryota SEC16A HGNC:29006 SEC16 homolog A (S. cerevisiae) O15027 Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein (Potential). Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. Endoplasmic reticulum (GO:0005783) 17192411 secreted 17 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Opisthokonta Eukaryota SEC16B HGNC:30301 SEC16 homolog B (S. cerevisiae) Q96JE7 Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity). cytoplasm 47 0 cytoplasm cytoplasm NA NA Eukaryota SEC22A HGNC:20260 SEC22 vesicle trafficking protein homolog A (S. cerevisiae) Q96IW7 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 8621431,8621431,8621431 endoplasmic reticulum membrane 94 4 endoplasmic reticulum. golgi apparatus multiple Tetrapoda Deuterostomia Eukaryota SEC22B HGNC:10700 SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) O75396 Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic reticulum- Golgi intermediate compartment membrane (By similarity). Golgi apparatus, cis-Golgi network membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (By similarity). Melanosome. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 9094723,15598749 endoplasmic reticulum membrane 29 1 endoplasmic reticulum. melanosome. mitochondrion multiple NA NA NA SEC22C HGNC:16828 SEC22 vesicle trafficking protein homolog C (S. cerevisiae) Q9BRL7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 9501016 endoplasmic reticulum membrane 100 4 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Euteleostomi Eukaryota SEC23A HGNC:10701 Sec23 homolog A (S. cerevisiae) Q15436 Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein (Potential). Note=In the ribosome-free transitional face of the ER and associated vesicles. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023) 8898360,8898360,15580264,8898360 nucleus 22 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Eukaryota SEC23B HGNC:10702 Sec23 homolog B (S. cerevisiae) Q15437 Golgi apparatus membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 1075675,10075675,10075675 nucleus 31 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota SEC23IP HGNC:17018 SEC23 interacting protein Q9Y6Y8 Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum (Probable). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 10400679,10400679,11112430,11112430,10400679 secreted 17 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Deuterostomia Eukaryota Eukaryota SEC24A HGNC:10703 SEC24 family member A O95486 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum membrane (By similarity). Golgi apparatus membrane (By similarity). Endoplasmic reticulum (GO:0005783) nucleus 16 1 nucleus nucleus Eukaryota Eukaryota Eukaryota SEC24B HGNC:10704 SEC24 family member B O95487 Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane (Potential). Golgi apparatus membrane (Potential). Golgi apparatus membrane (By similarity). Cytoplasm (GO:0005737) 10075675 nucleus 18 1 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota SEC24C HGNC:10705 SEC24 family member C P53992 Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane (Potential). Golgi apparatus membrane (Potential). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 10329445,10329445 nucleus 22 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Eukaryota SEC24D HGNC:10706 SEC24 family member D O94855 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum membrane (By similarity). Golgi apparatus membrane (By similarity). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 10329445,10329445 nucleus 31 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Eukaryota SEC31A HGNC:17052 SEC31 homolog A (S. cerevisiae) O94979 Cytoplasm (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Note=Associates with membranes in a GTP-dependent manner (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 10788476,17081983,10788476,10788476,17081983 secreted 15 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms SEC31B HGNC:23197 SEC31 homolog B (S. cerevisiae) Q9NQW1 Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein. nucleus 20 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms SEC61A1 HGNC:18276 Sec61 alpha 1 subunit (S. cerevisiae) P61619 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021) 10212142,10212142,9512475 endoplasmic reticulum membrane 100 10 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Cell.Organisms Cell.Organisms Cell.Organisms SEC61A2 HGNC:17702 Sec61 alpha 2 subunit (S. cerevisiae) Q9H9S3 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10212142,10212142 endoplasmic reticulum membrane 92 10 endoplasmic reticulum. golgi apparatus multiple Cell.Organisms Cell.Organisms Cell.Organisms SEC61B HGNC:16993 Sec61 beta subunit P60468 Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10212142 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Eukaryota Holozoa SEC61G HGNC:18277 Sec61 gamma subunit P60059 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Microsome (GO:0005792) 10212142,10212142,10212142,8107851 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota SEC62 HGNC:11846 SEC62 homolog (S. cerevisiae) Q99442 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10799540,17081983,17081983 endoplasmic reticulum membrane 22 2 cytoplasm. endoplasmic reticulum. nucleus multiple Opisthokonta Eukaryota Eukaryota SEC63 HGNC:21082 SEC63 homolog (S. cerevisiae) Q9UGP8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10219736,15598749 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms SECISBP2 HGNC:30972 SECIS binding protein 2 Q96T21 Nucleus (Potential). nucleus 70 0 nucleus nucleus Theria Chordata Eukaryota SECISBP2L HGNC:28997 SECIS binding protein 2-like Q93073 nucleus 89 0 nucleus nucleus Tetrapoda Bilateria Eukaryota SECTM1 HGNC:10707 secreted and transmembrane 1 Q8WVN6 Cell membrane; Single-pass type I membrane protein (Probable). Secreted. Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9480746,9480746,10652336 secreted 24 1 golgi apparatus. plasma membrane. secreted multiple Euarchontoglires Eutheria Boreoeutheria SEH1L HGNC:30379 SEH1-like (S. cerevisiae) Q96EE3 Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. Kinetochore (GO:0000776); Nuclear membrane (GO:0005635) 12196509,15146057,15561729 nucleus 100 0 nucleus. nucleus membrane multiple Opisthokonta Eukaryota Cell.Organisms SEL1L HGNC:10717 sel-1 suppressor of lin-12-like (C. elegans) Q9UBV2 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasmic vesicle (GO:0016023) 9858735 endoplasmic reticulum membrane 100 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms SEL1L2 HGNC:15897 sel-1 suppressor of lin-12-like 2 (C. elegans) Q5TEA6 Membrane; Single-pass type I membrane protein. endoplasmic reticulum membrane 42 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms SEL1L3 HGNC:29108 sel-1 suppressor of lin-12-like 3 (C. elegans) Q68CR1 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 12 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Cell.Organisms SELE HGNC:10718 selectin E P16581 Membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Endosome (GO:0005768); Lysosome (GO:0005764) 7541576,7694691,7694691,7694691 plasma membrane 18 1 endosome. lysosome. plasma membrane. secreted multiple Amniota Amniota Holozoa SELENBP1 HGNC:10719 selenium binding protein 1 Q13228 Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein (By similarity). Note=May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 1553752,10799528,10799528 cytoplasm 49 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Cell.Organisms Cell.Organisms SELL HGNC:10720 selectin L P14151 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10882119,1692315 secreted 20 0 secreted secreted Eutheria Mammalia Holozoa SELP HGNC:10721 selectin P (granule membrane protein 140kDa, antigen CD62) P16109 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11237770 secreted 28 1 plasma membrane plasma membrane Chordata Chordata Eukaryota SELPLG HGNC:10722 selectin P ligand Q14242 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10713099 plasma membrane 13 1 plasma membrane plasma membrane Euarchontoglires Eutheria Amniota SEMA3A HGNC:10723 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Q14563 Secreted (By similarity). Extracellular (GO:0005576) 12456642 secreted 94 0 secreted secreted Euteleostomi Euteleostomi Metazoa SEMA3B HGNC:10724 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Q13214 Secreted (By similarity). Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 11717452,8633026 secreted 43 0 endoplasmic reticulum. secreted multiple Euteleostomi Euteleostomi NA SEMA3C HGNC:10725 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C Q99985 Secreted. Extracellular (GO:0005576) 9405678 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa SEMA3D HGNC:10726 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D O95025 Secreted (By similarity). Integral to membrane (GO:0016021) secreted 83 0 secreted secreted Euteleostomi Euteleostomi Metazoa SEMA3E HGNC:10727 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E O15041 Secreted (By similarity). Extracellular (GO:0005576) 15386596 secreted 88 0 secreted secreted Euteleostomi Euteleostomi Metazoa SEMA3F HGNC:10728 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F Q13275 Secreted (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10702410,10702410, secreted 43 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa SEMA3G HGNC:30400 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G Q9NS98 Secreted (By similarity). Integral to membrane (GO:0016021) secreted 83 0 secreted secreted Euteleostomi Euteleostomi Metazoa SEMA4A HGNC:10729 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Q9H3S1 Cell membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 12906260,12893810 plasma membrane 80 1 plasma membrane plasma membrane Mammalia Euteleostomi Holozoa SEMA4B HGNC:10730 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B Q9NPR2 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Synapse (GO:0045202); Cytoplasm (GO:0005737) 15978582,15978582,17081983 plasma membrane 30 1 cytoplasm. plasma membrane multiple Tetrapoda Euteleostomi Metazoa SEMA4C HGNC:10731 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C Q9C0C4 Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 32 1 plasma membrane plasma membrane Mammalia Euteleostomi Holozoa SEMA4D HGNC:10732 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Q92854 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576); Nucleus (GO:0005634) 8955171,11254687,11254688,17081983 plasma membrane 100 1 nucleus. plasma membrane. secreted multiple Chordata Chordata Holozoa SEMA4F HGNC:10734 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F O95754 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10051670 plasma membrane 22 1 plasma membrane plasma membrane Theria Euteleostomi Eumetazoa SEMA4G HGNC:10735 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G Q9NTN9 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Metazoa SEMA5A HGNC:10736 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Q13591 Membrane; Single-pass type I membrane protein. plasma membrane 22 1 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota SEMA5B HGNC:10737 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B Q9P283 Membrane; Single-pass type III membrane protein. Integral to membrane (GO:0016021) plasma membrane 22 3 plasma membrane plasma membrane Euteleostomi Bilateria Eukaryota SEMA6A HGNC:10738 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A Q9H2E6 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10993894 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Metazoa SEMA6B HGNC:10739 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Q9H3T3 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Metazoa SEMA6C HGNC:10740 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Q9H3T2 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12110693 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Bilateria Metazoa SEMA6D HGNC:16770 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D Q8NFY4 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 4: Cell membrane; Single-pass type I membrane protein. Isoform 5: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cytoplasm. Plasma membrane (GO:0005886); Extracellular (GO:0005576);Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12110693,12110693/12110693,12110693 plasma membrane 40 1 cytoplasm. plasma membrane. secreted multiple Bilateria Bilateria Metazoa SEMA7A HGNC:10741 semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) O75326 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Extracellular (GO:0005576) 9712866,17377534,16199891 plasma membrane 13 1 plasma membrane. secreted multiple Amniota Euteleostomi Metazoa SEMG1 HGNC:10742 semenogelin I P04279 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 2912989,8833737 secreted 100 0 cytoplasm. secreted multiple Catarrhini Catarrhini Euarchontoglires SEMG2 HGNC:10743 semenogelin II Q02383 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 1517240,8833737 secreted 100 0 cytoplasm. secreted multiple Catarrhini Catarrhini Euarchontoglires SENP1 HGNC:17927 SUMO1/sentrin specific peptidase 1 Q9P0U3 Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. Nucleus (GO:0005634) 10652325,14563852 nucleus 33 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SENP2 HGNC:23116 SUMO1/sentrin/SMT3 specific peptidase 2 Q9HC62 Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. Nucleus (GO:0005634) 11896061,12192048 nucleus 22 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota SENP3 HGNC:17862 SUMO1/sentrin/SMT3 specific peptidase 3 Q9H4L4 Cytoplasm (By similarity). Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress. Nucleolus (GO:0005730); Nucleus (GO:0005634); Nucleus (GO:0005634) ,15635413,18259216,,15561729,17081983 nucleus 44 0 nucleus nucleus Theria Euteleostomi Eukaryota SENP5 HGNC:28407 SUMO1/sentrin specific peptidase 5 Q96HI0 Nucleus, nucleolus. nucleus 100 1 nucleus nucleus Eukaryota Eukaryota Eukaryota SENP6 HGNC:20944 SUMO1/sentrin specific peptidase 6 Q9GZR1 Nucleus. Cytoplasm (GO:0005737) 10799485 nucleus 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota SENP7 HGNC:30402 SUMO1/sentrin specific peptidase 7 Q9BQF6 nucleus 45 0 nucleus nucleus Chordata Eukaryota Eukaryota SENP8 HGNC:22992 SUMO/sentrin specific peptidase family member 8 Q96LD8 Cytoplasm (GO:0005737) nucleus 15 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms SEPHS1 HGNC:19685 selenophosphate synthetase 1 P49903 Isoform 1: Cell membrane. Nucleus membrane. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. cytoplasm 63 1 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms SEPHS2 HGNC:19686 selenophosphate synthetase 2 Q99611 cytoplasm 47 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms SEPN1 HGNC:15999 selenoprotein N, 1 Q9NZV5 Isoform 2: Endoplasmic reticulum membrane (Probable). Note=Probably membrane-associated. Endoplasmic reticulum (GO:0005783) 12700173 nucleus 51 34 endoplasmic reticulum endoplasmic reticulum Eutheria Deuterostomia Metazoa SEPP1 HGNC:10751 selenoprotein P, plasma, 1 P49908 Secreted. Extracellular (GO:0005576) 8421687,16188874 secreted 100 0 secreted secreted NA NA Eumetazoa SEPSECS HGNC:30605 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Q9HD40 Cytoplasm. cytoplasm 100 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms SEPT1 HGNC:2879 septin 1 Q8WYJ6 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9811347,15598749 cytoplasm 32 0 cytoplasm. mitochondrion multiple Eutheria Mammalia Eukaryota SEPT10 HGNC:14349 septin 10 Q9P0V9 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Using a GFP-fusion protein, detected in the nucleus (PubMed:12711328). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12711328,12711328 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SEPT11 HGNC:25589 septin 11 Q9NVA2 Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon (By similarity). Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 15140406,15140406,15196925 cytoplasm 69 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SEPT12 HGNC:26348 septin 12 Q8IYM1 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. cytoplasm 53 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota SEPT14 HGNC:33280 septin 14 Q6ZU15 Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SEPT2 HGNC:7729 septin 2 Q15019 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane (By similarity). Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Microtubule (GO:0005874); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 9811347,17081983,10321247,15635413,15774761,12388755,15598749,17081983 cytoplasm 35 0 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Bilateria Cell.Organisms SEPT3 HGNC:10750 septin 3 Q9UH03 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 15107017,15485489,15107017 cytoplasm 67 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Cell.Organisms SEPT4 HGNC:9165 septin 4 O43236 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Isoform ARTS: Mitochondrion. Nucleus. Note=While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Cytosol (GO:0005829); Unknown membrane (None) 11146656,15029247,11146656,15029247,12695511,10340703,10340703,10340703 cytoplasm 32 0 cytoplasm. mitochondrion. nucleus multiple Mammalia Bilateria Eukaryota SEPT5 HGNC:9164 septin 5 Q99719 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=In platelets, found in areas surrounding alpha-granules. Cytoplasm (GO:0005737); Synaptic vesicle (GO:0008021); Membrane fraction (GO:0005624); Nucleus (GO:0005634) 15214843,10321247,10321247,15214843 cytoplasm 33 0 cytoplasm. nucleus multiple Euarchontoglires Euteleostomi Eukaryota SEPT6 HGNC:15848 septin 6 Q14141 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Cytoplasmic vesicle (GO:0016023) 11064363 cytoplasm 64 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SEPT7 HGNC:1717 septin 7 Q16181 Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Cytoskeleton (GO:0005856); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10931866,15635413,15598749,17081983,17081983 cytoplasm 37 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Eukaryota SEPT8 HGNC:16511 septin 8 Q92599 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=In platelets, found in areas surrounding alpha-granules. Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737); Cell surface (GO:0009986) 15214843,15214843,15116257 cytoplasm 70 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SEPT9 HGNC:7323 septin 9 Q9UHD8 Cytoplasm, cytoskeleton. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. Cytoskeleton (GO:0005856); Nucleus (GO:0005634); Microtubule (GO:0005874) 12388755,16424018,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta NA SEPW1 HGNC:10752 selenoprotein W, 1 P63302 Cytoplasm. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 7896009,7896009 cytoplasm 100 1 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota SERAC1 HGNC:21061 serine active site containing 1 Q96JX3 Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum. Mitochondrion. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum- mitochondria interface. cytoplasm 20 1 endoplasmic reticulum. mitochondrion multiple Bilateria Cell.Organisms Cell.Organisms SERBP1 HGNC:17860 SERPINE1 mRNA binding protein 1 Q8NC51 Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Also found in perinuclear regions. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Nucleus (GO:0005634);Cytoplasm (GO:0005737) 17081983,17081983/12505151,12505151/17081983 cytoplasm 25 0 cytoplasm. nucleus multiple Chordata Chordata Metazoa SERF1A HGNC:10755 small EDRK-rich factor 1A (telomeric) O75920 nucleus 20 1 nucleus nucleus Amniota Eukaryota Eukaryota SERF1B HGNC:10756 small EDRK-rich factor 1B (centromeric) O75920 nucleus 20 1 nucleus nucleus Amniota Eukaryota NA SERF2 HGNC:10757 small EDRK-rich factor 2 P84101 Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 36 0 nucleus nucleus Bilateria Eukaryota Eukaryota SERGEF HGNC:17499 secretion regulating guanine nucleotide exchange factor Q9UGK8 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10571079,10571079 cytoplasm 17 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms SERHL HGNC:14408 serine hydrolase-like Q9NQF3 Cytoplasmic vesicle (GO:0016023); Peroxisome (GO:0005777) 11352564,11352564 mitochondrion 80 0 peroxisome peroxisome Chordata Cell.Organisms NA SERHL2 HGNC:29446 serine hydrolase-like 2 Q9H4I8 Cytoplasm, perinuclear region (By similarity). Peroxisome (By similarity). Note=Concentrated in perinuclear vesicles (By similarity). May be located in peroxisomes (By similarity). mitochondrion 90 0 mitochondrion mitochondrion Chordata Cell.Organisms Cell.Organisms SERINC1 HGNC:13464 serine incorporator 1 Q9NRX5 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10637174,17081983,17081983 endoplasmic reticulum membrane 95 10 cytoplasm. nucleus. plasma membrane multiple Eukaryota Eukaryota Eukaryota SERINC2 HGNC:23231 serine incorporator 2 Q96SA4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 44 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi NA SERINC3 HGNC:11699 serine incorporator 3 Q13530 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10559794 endoplasmic reticulum membrane 52 10 plasma membrane plasma membrane Eukaryota Eukaryota Eukaryota SERINC4 HGNC:32237 serine incorporator 4 A6NH21 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 25 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Eukaryota SERINC5 HGNC:18825 serine incorporator 5 Q86VE9 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 26 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Chordata Eukaryota SERP1 HGNC:10759 stress-associated endoplasmic reticulum protein 1 Q9Y6X1 Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Endoplasmic reticulum (GO:0005783) 10601334 mitochondrion 2 1 endoplasmic reticulum endoplasmic reticulum Theria Eukaryota Eukaryota SERP2 HGNC:20607 stress-associated endoplasmic reticulum protein family member 2 Q8N6R1 Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side (Potential). Integral to membrane (GO:0016021) mitochondrion 3 1 mitochondrion mitochondrion Theria Eukaryota Eukaryota SERPINA1 HGNC:8941 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 P01009 Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 1406456,12796484,6604220,12324297,16188874,10677536,11427540,15100318,12796484,1967187,11260148 secreted 100 0 cytoplasm. endoplasmic reticulum. lysosome. secreted multiple Euteleostomi Bilateria Cell.Organisms SERPINA10 HGNC:15996 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 Q9UK55 Secreted. Extracellular (GO:0005576) 9689066 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms SERPINA11 HGNC:19193 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 Q86U17 Secreted (Potential). secreted 31 0 secreted secreted Eutheria Eutheria Cell.Organisms SERPINA12 HGNC:18359 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Q8IW75 Secreted (Potential). secreted 25 0 secreted secreted Theria Bilateria Cell.Organisms SERPINA2 HGNC:8985 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) P20848 Endoplasmic reticulum. secreted 51 0 endoplasmic reticulum endoplasmic reticulum NA NA NA SERPINA3 HGNC:16 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 P01011 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7588564,16188874,2945424,6762318 secreted 100 0 cytoplasm. nucleus. secreted multiple Euteleostomi Bilateria Cell.Organisms SERPINA4 HGNC:8948 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 P29622 Secreted. Extracellular (GO:0005576) 12757180,10547191,8648266 secreted 100 0 secreted secreted Euteleostomi Bilateria Cell.Organisms SERPINA5 HGNC:8723 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 P05154 Secreted, extracellular space. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10438718,9473218,15822942,10438718,10438718 secreted 100 0 nucleus. secreted multiple Euarchontoglires Eutheria Cell.Organisms SERPINA6 HGNC:1540 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 P08185 Secreted. Extracellular (GO:0005576) 9739422 secreted 100 0 secreted secreted Theria Theria Cell.Organisms SERPINA7 HGNC:11583 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 P05543 Secreted. Extracellular (GO:0005576) 3094014 secreted 100 0 secreted secreted Mammalia Mammalia Cell.Organisms SERPINA9 HGNC:15995 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 Q86WD7 Isoform 1: Secreted. Isoform 2: Cytoplasm (Probable). Isoform 3: Cytoplasm (Probable). Isoform 4: Cytoplasm (Probable). Isoform 5: Cytoplasm (Probable). Isoform 6: Cytoplasm (Probable). Isoform 7: Membrane; Single-pass type II membrane protein (Potential). secreted 41 0 cytoplasm. secreted multiple Euarchontoglires Eutheria Cell.Organisms SERPINB1 HGNC:3311 serpin peptidase inhibitor, clade B (ovalbumin), member 1 P30740 Cytoplasm (By similarity). Cytoplasmic granule. Cytoplasm (GO:0005737) cytoplasm 78 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SERPINB10 HGNC:8942 serpin peptidase inhibitor, clade B (ovalbumin), member 10 P48595 Nucleus. Cytoplasm. Note=Mostly found in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10196205,10871600 cytoplasm 36 2 cytoplasm. nucleus multiple NA NA Cell.Organisms SERPINB11 HGNC:14221 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) Q96P15 Cytoplasm (By similarity). cytoplasm 36 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SERPINB12 HGNC:14220 serpin peptidase inhibitor, clade B (ovalbumin), member 12 Q96P63 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Extracellular (GO:0005576) 11604408,16188874 cytoplasm 37 2 cytoplasm. secreted multiple Amniota Amniota Cell.Organisms SERPINB13 HGNC:8944 serpin peptidase inhibitor, clade B (ovalbumin), member 13 Q9UIV8 Cytoplasm. Cytoplasm (GO:0005737) 12809493 cytoplasm 100 2 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms SERPINB2 HGNC:8584 serpin peptidase inhibitor, clade B (ovalbumin), member 2 P05120 Cytoplasm. Secreted, extracellular space. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Nucleus (GO:0005634) 10438806,10393034,7506655,15346200 cytoplasm 38 2 cytoplasm. nucleus. secreted multiple Amniota Amniota Cell.Organisms SERPINB3 HGNC:10569 serpin peptidase inhibitor, clade B (ovalbumin), member 3 P29508 Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 2208001,16188874 cytoplasm 100 2 cytoplasm. secreted multiple Bilateria Cell.Organisms Cell.Organisms SERPINB4 HGNC:10570 serpin peptidase inhibitor, clade B (ovalbumin), member 4 P48594 Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level. Cytoplasm (GO:0005737) 10956412 cytoplasm 100 2 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SERPINB5 HGNC:8949 serpin peptidase inhibitor, clade B (ovalbumin), member 5 P36952 Secreted, extracellular space. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Cytoplasmic vesicle (GO:0016023) 9433491,9433491,9389773,9389773,9389773,9389773 secreted 100 2 cytoplasm. endoplasmic reticulum. plasma membrane. secreted multiple Tetrapoda Tetrapoda Cell.Organisms SERPINB6 HGNC:8950 serpin peptidase inhibitor, clade B (ovalbumin), member 6 P35237 Cytoplasm. Cytoplasm (GO:0005737) 8136380,8408007,8662739 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SERPINB7 HGNC:13902 serpin peptidase inhibitor, clade B (ovalbumin), member 7 O75635 Cytoplasm (By similarity). Cytoplasm (GO:0005737) cytoplasm 26 2 cytoplasm cytoplasm Theria Bilateria Cell.Organisms SERPINB8 HGNC:8952 serpin peptidase inhibitor, clade B (ovalbumin), member 8 P50452 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12417609,12417609,8530382,9442015 cytoplasm 100 0 cytoplasm. nucleus. secreted multiple Eutheria Eutheria Cell.Organisms SERPINB9 HGNC:8955 serpin peptidase inhibitor, clade B (ovalbumin), member 9 P50453 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8910377,11485349 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms SERPINC1 HGNC:775 serpin peptidase inhibitor, clade C (antithrombin), member 1 P01008 Secreted, extracellular space. Extracellular (GO:0005576) 2991253,16188874 secreted 100 0 secreted secreted Euteleostomi Bilateria Cell.Organisms SERPIND1 HGNC:4838 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 P05546 Extracellular (GO:0005576) 3379101 cytoplasm 18 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms SERPINE1 HGNC:8583 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 P05121 Secreted. Extracellular (GO:0005576) 1870265 secreted 100 0 secreted secreted Euteleostomi Bilateria Cell.Organisms SERPINE2 HGNC:8951 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 P07093 Secreted, extracellular space. Extracellular (GO:0005576) 1334458 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms SERPINE3 HGNC:24774 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 A8MV23 Secreted (Potential). secreted 15 0 secreted secreted NA NA Cell.Organisms SERPINF1 HGNC:8824 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 P36955 Secreted. Melanosome. Note=Enriched in stage I melanosomes. Extracellular (GO:0005576) 12603315,16188874 secreted 13 0 melanosome. secreted multiple Euteleostomi Euteleostomi Cell.Organisms SERPINF2 HGNC:9075 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 P08697 Secreted. Extracellular (GO:0005576) 2433286,16188874 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms SERPING1 HGNC:1228 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 P05155 Secreted. Extracellular matrix (GO:0005578); Extracellular (GO:0005576) 12492481,16188874 secreted 100 0 secreted secreted Mammalia Euteleostomi Cell.Organisms SERPINH1 HGNC:1546 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) P50454 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Nucleolus (GO:0005730) 10506936,10227388,15635413 endoplasmic reticulum 100 0 endoplasmic reticulum. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms SERPINI1 HGNC:8943 serpin peptidase inhibitor, clade I (neuroserpin), member 1 Q99574 Secreted. Cytoplasmic vesicle (GO:0016023) 12354288 secreted 100 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms SERPINI2 HGNC:8945 serpin peptidase inhibitor, clade I (pancpin), member 2 O75830 Secreted (Probable). Extracellular (GO:0005576) 10097100 secreted 25 0 secreted secreted Mammalia Tetrapoda Cell.Organisms SERTAD1 HGNC:17932 SERTA domain containing 1 Q9UHV2 Nucleus (GO:0005634) 10580009 nucleus 23 0 nucleus nucleus Mammalia Tetrapoda Tetrapoda SERTAD2 HGNC:30784 SERTA domain containing 2 Q14140 nucleus 20 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria SERTAD3 HGNC:17931 SERTA domain containing 3 Q9UJW9 Nucleus. Nucleus (GO:0005634) 10982866 nucleus 100 0 nucleus nucleus Eutheria Eutheria Boreoeutheria SERTAD4 HGNC:25236 SERTA domain containing 4 Q9NUC0 nucleus 84 0 nucleus nucleus Tetrapoda Tetrapoda Craniata SERTM1 HGNC:33792 serine-rich and transmembrane domain containing 1 A2A2V5 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 35 1 secreted secreted Mammalia Euteleostomi Euteleostomi SESN1 HGNC:21595 sestrin 1 Q9Y6P5 Nucleus. Nucleus (GO:0005634) 9926927 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota SESN2 HGNC:20746 sestrin 2 P58004 Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Theria Bilateria Eukaryota SESN3 HGNC:23060 sestrin 3 P58005 Nucleus (GO:0005634) nucleus 55 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota SESTD1 HGNC:18379 SEC14 and spectrin domains 1 Q86VW0 cytoplasm 11 0 cytoplasm cytoplasm Bilateria Bilateria Metazoa SET HGNC:10760 SET nuclear oncogene Q01105 Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium. The SET complex is associated with the endoplasmic reticulum. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 8192856,17245428,17081983,11555662,11741927,17245428,17081983,17245428,15561729 nucleus 33 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Eukaryota SETBP1 HGNC:15573 SET binding protein 1 Q9Y6X0 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 11231286,11231286,14718574 nucleus 100 1 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Craniata SETD1A HGNC:29010 SET domain containing 1A O15047 Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes. Nucleus (GO:0005634) ,12670868,16253997, nucleus 100 0 nucleus nucleus Theria Eukaryota Cell.Organisms SETD1B HGNC:29187 SET domain containing 1B Q9UPS6 Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes. nucleus 100 0 nucleus nucleus Chordata Chordata Cell.Organisms SETD2 HGNC:18420 SET domain containing 2 Q9BYW2 Nucleus (Probable). Chromosome (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10958656,17081983 nucleus 83 0 cytoplasm. nucleus multiple Chordata Opisthokonta Cell.Organisms SETD3 HGNC:20493 SET domain containing 3 Q86TU7 Nucleus (By similarity). mitochondrion 12 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota SETD4 HGNC:1258 SET domain containing 4 Q9NVD3 mitochondrion 10 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota SETD5 HGNC:25566 SET domain containing 5 Q9C0A6 nucleus 35 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SETD6 HGNC:26116 SET domain containing 6 Q8TBK2 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota SETD7 HGNC:30412 SET domain containing (lysine methyltransferase) 7 Q8WTS6 Nucleus. Chromosome (Probable). Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms SETD8 HGNC:29489 SET domain containing (lysine methyltransferase) 8 Q9NQR1 Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. Nucleus (GO:0005634) 12086618 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms SETD9 HGNC:28508 SET domain containing 9 Q8NE22 mitochondrion 17 0 mitochondrion mitochondrion Tetrapoda Deuterostomia Eukaryota SETDB1 HGNC:10761 SET domain, bifurcated 1 Q15047 Nucleus. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin. Nucleus (GO:0005634); Chromosome (GO:0005694) 11959841,16682412 nucleus 100 0 nucleus nucleus Chordata Bilateria Cell.Organisms SETDB2 HGNC:20263 SET domain, bifurcated 2 Q96T68 Nucleus. Chromosome (Probable). Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms SETMAR HGNC:10762 SET domain and mariner transposase fusion gene Q53H47 Nucleus (Probable). Chromosome (Probable). nucleus 20 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms SETX HGNC:445 senataxin Q7Z333 Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm. Note=May be detected in the nucleolus only in cycling cells (By similarity). Most abundant in the nucleus. Detected in granules. Colocalized in cycling cells with FBL in the nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Cell.Organisms SEZ6 HGNC:15955 seizure related 6 homolog (mouse) Q53EL9 Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized on dendrites and in the synaptic and postsynaptic fraction (By similarity). Integral to membrane (GO:0016021) secreted 13 1 secreted secreted Tetrapoda Euteleostomi Cell.Organisms SEZ6L HGNC:10763 seizure related 6 homolog (mouse)-like Q9BYH1 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). secreted 12 1 secreted secreted Tetrapoda Euteleostomi Holozoa SEZ6L2 HGNC:30844 seizure related 6 homolog (mouse)-like 2 Q6UXD5 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Note=Detected on cell surface of lung-cancer. Plasma membrane (GO:0005886) secreted 13 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa SF1 HGNC:12950 splicing factor 1 Q15637 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/7912130,1406644,15302935 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SF3A1 HGNC:10765 splicing factor 3a, subunit 1, 120kDa Q15459 Nucleus (By similarity). Nucleus (GO:0005634) ,15647371,15316075,19059367,11013263, nucleus 25 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SF3A2 HGNC:10766 splicing factor 3a, subunit 2, 66kDa Q15428 Nucleus (By similarity). Nucleus (GO:0005634) 8211113,9016565 plasma membrane 34 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SF3A3 HGNC:10767 splicing factor 3a, subunit 3, 60kDa Q12874 Nucleus speckle. Nucleus (GO:0005634); Nucleolus (GO:0005730) 8022796,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SF3B1 HGNC:10768 splicing factor 3b, subunit 1, 155kDa O75533 Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm. Nucleus (GO:0005634) 9585501,12738865,10490618,19059367 nucleus 100 4 nucleus nucleus Eukaryota Eukaryota Eukaryota SF3B2 HGNC:10769 splicing factor 3b, subunit 2, 145kDa Q13435 Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10490618,7958871,8566756,19059367,15635413,17081983 nucleus 16 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SF3B3 HGNC:10770 splicing factor 3b, subunit 3, 130kDa Q15393 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,10490618,10428969,19059367,11013263,,10428969 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SF3B4 HGNC:10771 splicing factor 3b, subunit 4, 49kDa Q15427 Nucleus (By similarity). Nucleus (GO:0005634) 15351706 nucleus 28 0 nucleus nucleus Eukaryota Eukaryota NA SF3B5 HGNC:21083 splicing factor 3b, subunit 5, 10kDa Q9BWJ5 Nucleus (By similarity). nucleus 18 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SF3B6 HGNC:30096 splicing factor 3b, subunit 6, 14kDa Q9Y3B4 Nucleus (Potential). nucleus 29 0 nucleus nucleus NA NA NA SFI1 HGNC:29064 Sfi1 homolog, spindle assembly associated (yeast) A8K8P3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized close to the centriole. Centriole (GO:0005814) 14504268 cytoplasm 100 1 cytoplasm cytoplasm Deuterostomia Deuterostomia Opisthokonta SFMBT1 HGNC:20255 Scm-like with four mbt domains 1 Q9UHJ3 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa SFMBT2 HGNC:20256 Scm-like with four mbt domains 2 Q5VUG0 nucleus 47 0 nucleus nucleus Euteleostomi Deuterostomia Holozoa SFN HGNC:10773 stratifin P31947 Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway. Cytoplasm (GO:0005737) 10524633,15696159,16902409 cytoplasm 65 0 cytoplasm. secreted multiple Mammalia Mammalia Eukaryota SFPQ HGNC:10774 splicing factor proline/glutamine-rich P23246 Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10653975,11161712,9848648,19059367,15635413,11790298,17081983 nucleus 52 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms SFR1 HGNC:29574 SWI5-dependent recombination repair 1 Q86XK3 Nucleus (By similarity). nucleus 48 0 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta SFRP1 HGNC:10776 secreted frizzled-related protein 1 Q8N474 Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding. Extracellular (GO:0005576) 9192640 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa SFRP2 HGNC:10777 secreted frizzled-related protein 2 Q96HF1 Secreted (By similarity). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9096311,9391078,17081983 secreted 98 0 cytoplasm. secreted multiple Chordata Chordata Metazoa SFRP4 HGNC:10778 secreted frizzled-related protein 4 Q6FHJ7 Secreted. Note=Cytoplasmic in ovarian tumor cells. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 14760084,14517837,14760084 secreted 100 0 secreted secreted Amniota Amniota Metazoa SFRP5 HGNC:10779 secreted frizzled-related protein 5 Q5T4F7 Secreted (By similarity). Extracellular (GO:0005576) 10072424 secreted 48 0 secreted secreted Deuterostomia Bilateria Metazoa SFSWAP HGNC:10790 splicing factor, suppressor of white-apricot homolog (Drosophila) Q12872 Nucleus (Potential). Nucleus (GO:0005634) 8940107,17081983 nucleus 27 0 nucleus nucleus Chordata Bilateria Eukaryota SFT2D1 HGNC:21102 SFT2 domain containing 1 Q8WV19 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 89 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota SFT2D2 HGNC:25140 SFT2 domain containing 2 O95562 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 12 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota SFT2D3 HGNC:28767 SFT2 domain containing 3 Q587I9 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 13 4 golgi apparatus membrane golgi apparatus membrane Theria Eukaryota Eutheria SFTA2 HGNC:18386 surfactant associated 2 Q6UW10 Secreted (Probable). Extracellular (GO:0005576) secreted 91 0 secreted secreted Catarrhini Eutheria NA SFTA3 HGNC:18387 surfactant associated 3 P0C7M3 secreted 60 0 secreted secreted NA NA Primates SFTPA1 HGNC:10798 surfactant protein A1 Q8IWL2 Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783) 11751208,8494055 secreted 36 0 endoplasmic reticulum. secreted multiple Tetrapoda Chordata Cell.Organisms SFTPA2 HGNC:10799 surfactant protein A2 Q8IWL1 Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. Extracellular (GO:0005576) 9698591 secreted 32 0 secreted secreted Tetrapoda Chordata Cell.Organisms SFTPB HGNC:10801 surfactant protein B P07988 Secreted, extracellular space, surface film. Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 2475034,10722708,10722708,1415726 secreted 100 0 endoplasmic reticulum. golgi apparatus. secreted multiple Mammalia Mammalia Eumetazoa SFTPC HGNC:10802 surfactant protein C P11686 Secreted, extracellular space, surface film. Plasma membrane (GO:0005886) 1859376 secreted 100 1 plasma membrane. secreted multiple Theria Theria Euteleostomi SFTPD HGNC:10803 surfactant protein D P35247 Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. Extracellular (GO:0005576) 1932100 secreted 62 0 secreted secreted Mammalia Chordata Cell.Organisms SFXN1 HGNC:16085 sideroflexin 1 Q9H9B4 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11274051,15589833,15060089,12150972,11722557,8132490,14634051,15598749,11274051,14634051 mitochondrion membrane 94 6 cytoplasm. mitochondrion. plasma membrane multiple Bilateria Bilateria Eukaryota SFXN2 HGNC:16086 sideroflexin 2 Q96NB2 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) mitochondrion membrane 45 5 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Eukaryota SFXN3 HGNC:16087 sideroflexin 3 Q9BWM7 Mitochondrion membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) mitochondrion membrane 100 6 mitochondrion membrane mitochondrion membrane Eutheria Euteleostomi Eukaryota SFXN4 HGNC:16088 sideroflexin 4 Q6P4A7 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) 14756423 mitochondrion membrane 10 6 mitochondrion membrane mitochondrion membrane Amniota Euteleostomi Eukaryota SFXN5 HGNC:16073 sideroflexin 5 Q8TD22 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 12150972 mitochondrion membrane 98 6 mitochondrion mitochondrion Chordata Eukaryota Eukaryota SGCA HGNC:10805 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) Q16586 Cell membrane, sarcolemma; Single-pass type I membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Plasma membrane (GO:0005886) 7937874 plasma membrane 56 1 plasma membrane plasma membrane Mammalia Mammalia Eumetazoa SGCB HGNC:10806 sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) Q16585 Cell membrane, sarcolemma; Single-pass type II membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10928275,10928275,10928275 plasma membrane 34 1 cytoplasm. nucleus. plasma membrane multiple Bilateria Bilateria Metazoa SGCD HGNC:10807 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) Q92629 Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10928275,10341878 plasma membrane 35 1 cytoplasm. plasma membrane multiple Euteleostomi Bilateria Holozoa SGCE HGNC:10808 sarcoglycan, epsilon O43556 Cell membrane, sarcolemma; Single-pass membrane protein (Potential). Cytoplasm, cytoskeleton (By similarity). Plasma membrane (GO:0005886) 12060343 plasma membrane 53 1 plasma membrane plasma membrane Euteleostomi Bilateria Eumetazoa SGCG HGNC:10809 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) Q13326 Cell membrane, sarcolemma; Single-pass type II membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Sarcoplasmic reticulum (GO:0016529) 8641426 plasma membrane 56 1 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Holozoa SGCZ HGNC:14075 sarcoglycan, zeta Q96LD1 Cell membrane, sarcolemma; Single-pass type II membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Plasma membrane (GO:0005886) 12189167 plasma membrane 39 1 plasma membrane plasma membrane Amniota Deuterostomia Holozoa SGIP1 HGNC:25412 SH3-domain GRB2-like (endophilin) interacting protein 1 Q9BQI5 Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (Probable). cytoplasm 24 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Opisthokonta SGK1 HGNC:10810 serum/glucocorticoid regulated kinase 1 O00141 Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Isoform 2: Cell membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12631736,12631736,12218062 cytoplasm 29 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Eukaryota Cell.Organisms SGK2 HGNC:13900 serum/glucocorticoid regulated kinase 2 Q9HBY8 Cytoplasm. Nucleus. nucleus 29 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms SGK3 HGNC:10812 serum/glucocorticoid regulated kinase family, member 3 Q96BR1 Cytoplasmic vesicle (By similarity). Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its co-localization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Co-localizes with SLC9A3/NHE3 in the recycling endosomes. Endosome (GO:0005768); Nucleus (GO:0005634) 11514587,16888620,11514587 nucleus 29 0 endosome. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms SGMS1 HGNC:29799 sphingomyelin synthase 1 Q86VZ5 Golgi apparatus membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 14976195,14685263,14976195,14685263,10544266,14685263 golgi apparatus membrane 100 6 golgi apparatus. golgi apparatus membrane. nucleus. plasma membrane multiple Chordata Eukaryota Eukaryota SGMS2 HGNC:28395 sphingomyelin synthase 2 Q8NHU3 Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase. Plasma membrane (GO:0005886) 14685263 golgi apparatus membrane 52 6 golgi apparatus membrane. plasma membrane multiple Euteleostomi Eukaryota Eukaryota SGOL1 HGNC:25088 shugoshin-like 1 (S. pombe) Q5FBB7 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. During prometaphase, it localizes to a single focus, while at metaphase, it localizes to 2 spots corresponding to the 2 centromeres. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Localizes to the inner kinetochore from prophase to early metaphase. Co-localizes with NEK2 and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle. Chromosome (GO:0005694) 15737064,15604152,16541025,17113138 nucleus 35 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Euteleostomi SGOL2 HGNC:30812 shugoshin-like 2 (S. pombe) Q562F6 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore (By similarity). Note=During meiosis I, accumulates at centromeres during diplotene, and co-localizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB. Chromosome (GO:0005694) 16541025 nucleus 100 0 nucleus nucleus Theria Theria Euteleostomi SGPL1 HGNC:10817 sphingosine-1-phosphate lyase 1 O95470 Endoplasmic reticulum membrane; Single-pass type III membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 14570870,2061324,15598749 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms SGPP1 HGNC:17720 sphingosine-1-phosphate phosphatase 1 Q9BX95 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12815058,17081983,17081983 endoplasmic reticulum membrane 100 9 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Euteleostomi Bilateria Cell.Organisms SGPP2 HGNC:19953 sphingosine-1-phosphate phosphatase 2 Q8IWX5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 12411432 endoplasmic reticulum membrane 100 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Amniota Eukaryota Cell.Organisms SGSH HGNC:10818 N-sulfoglucosamine sulfohydrolase P51688 Lysosome. Lysosome (GO:0005764) 9405287 golgi apparatus 22 0 lysosome lysosome Deuterostomia Cell.Organisms Cell.Organisms SGSM1 HGNC:29410 small G protein signaling modulator 1 Q2NKQ1 Golgi apparatus, trans-Golgi network (By similarity). golgi apparatus 92 0 golgi apparatus golgi apparatus Bilateria Bilateria Eukaryota SGSM2 HGNC:29026 small G protein signaling modulator 2 O43147 golgi apparatus 56 0 golgi apparatus golgi apparatus Bilateria Bilateria Eukaryota SGSM3 HGNC:25228 small G protein signaling modulator 3 Q96HU1 Cytoplasm. Plasma membrane (GO:0005886) 15709751 cytoplasm 100 4 cytoplasm. plasma membrane multiple Bilateria Bilateria Eukaryota SGTA HGNC:10819 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha O43765 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11878889,9557704,17081983,11878889,9557704 cytoplasm 18 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SGTB HGNC:23567 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Q96EQ0 cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms SH2B1 HGNC:30417 SH2B adaptor protein 1 Q9NRF2 Cytoplasm (By similarity). Membrane (Probable). Nucleus (By similarity). Note=Shuttles between the nucleus and the cytoplasm (By similarity). cytoplasm 24 0 cytoplasm cytoplasm Mammalia Deuterostomia Holozoa SH2B2 HGNC:17381 SH2B adaptor protein 2 O14492 Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11997497,11997497 cytoplasm 24 0 cytoplasm cytoplasm Chordata Bilateria NA SH2B3 HGNC:29605 SH2B adaptor protein 3 Q9UQQ2 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10799879,10799879 cytoplasm 20 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa SH2D1A HGNC:10820 SH2 domain containing 1A O60880 Cytoplasm (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11477403,11389028 cytoplasm 22 0 cytoplasm cytoplasm Theria Chordata Holozoa SH2D1B HGNC:30416 SH2 domain containing 1B O14796 Cytoplasm (GO:0005737) 12787752 cytoplasm 21 0 cytoplasm cytoplasm Theria Amniota Holozoa SH2D2A HGNC:10821 SH2 domain containing 2A Q9NP31 Cytoplasm. Cytoplasm (GO:0005737) 9468509 cytoplasm 100 0 cytoplasm cytoplasm Theria Amniota Holozoa SH2D3A HGNC:16885 SH2 domain containing 3A Q9BRG2 cytoplasm 30 0 cytoplasm cytoplasm Theria Euteleostomi Holozoa SH2D3C HGNC:16884 SH2 domain containing 3C Q8N5H7 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa SH2D4A HGNC:26102 SH2 domain containing 4A Q9H788 Cytoplasm. Note=Located at podocyte foot processes (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Holozoa SH2D4B HGNC:31440 SH2 domain containing 4B Q5SQS7 cytoplasm 37 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa SH2D5 HGNC:28819 SH2 domain containing 5 Q6ZV89 cytoplasm 47 0 cytoplasm cytoplasm Theria Euteleostomi Eumetazoa SH2D6 HGNC:30439 SH2 domain containing 6 Q7Z4S9 cytoplasm 25 0 cytoplasm cytoplasm Eutheria Mammalia Holozoa SH2D7 HGNC:34549 SH2 domain containing 7 A6NKC9 cytoplasm 30 0 cytoplasm cytoplasm Mammalia Mammalia Holozoa SH3BGR HGNC:10822 SH3 domain binding glutamate-rich protein P55822 nucleus 55 0 nucleus nucleus Euteleostomi Bilateria Eukaryota SH3BGRL HGNC:10823 SH3 domain binding glutamate-rich protein like O75368 nucleus 56 0 nucleus nucleus Amniota Euteleostomi Eukaryota SH3BGRL2 HGNC:15567 SH3 domain binding glutamate-rich protein like 2 Q9UJC5 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12095696,12095696 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SH3BGRL3 HGNC:15568 SH3 domain binding glutamate-rich protein like 3 Q9H299 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 10554026,11444877,11344125,11137621,11444877,11344125 nucleus 31 0 cytoplasm. nucleus multiple Euarchontoglires Deuterostomia Eukaryota SH3BP1 HGNC:10824 SH3-domain binding protein 1 Q9Y3L3 plasma membrane 22 1 plasma membrane plasma membrane Human Amniota Eukaryota SH3BP2 HGNC:10825 SH3-domain binding protein 2 P78314 Cytoplasm (GO:0005737) 11390470 cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta SH3BP4 HGNC:10826 SH3-domain binding protein 4 Q9P0V3 Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus (Probable). Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus. cytoplasm 26 0 nucleus nucleus Chordata Chordata Opisthokonta SH3BP5 HGNC:10827 SH3-domain binding protein 5 (BTK-associated) O60239 Mitochondrion. Mitochondrion (GO:0005739) 12167088,15158451,15506969 mitochondrion 100 0 mitochondrion mitochondrion Chordata Bilateria Eukaryota SH3BP5L HGNC:29360 SH3-binding domain protein 5-like Q7L8J4 mitochondrion 31 0 mitochondrion mitochondrion Theria Bilateria Eukaryota SH3D19 HGNC:30418 SH3 domain containing 19 Q5HYK7 Cytoplasm. Nucleus. Note=Is recruited to the nucleus by the KMT2A/MLL1-EEN fusion protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 14551139,14551139,15280379 cytoplasm 30 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota SH3D21 HGNC:26236 SH3 domain containing 21 A4FU49 cytoplasm 42 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota SH3GL1 HGNC:10830 SH3-domain GRB2-like 1 Q99961 Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein (By similarity). Cell projection, podosome. Note=Associated with postsynaptic endosomes in hippocampal neurons (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 9238017,15944398,15944398 cytoplasm 38 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Eukaryota SH3GL2 HGNC:10831 SH3-domain GRB2-like 2 Q99962 Cytoplasm. Membrane; Peripheral membrane protein. Note=Concentrated in presynaptic nerve terminals in neurons. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12127567,17081983 peroxisome membrane 32 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SH3GL3 HGNC:10832 SH3-domain GRB2-like 3 Q99963 Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein (By similarity). Note=Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons (By similarity). cytoplasm 29 0 cytoplasm cytoplasm Opisthokonta Opisthokonta Eukaryota SH3GLB1 HGNC:10833 SH3-domain GRB2-like endophilin B1 Q9Y371 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein (By similarity). Mitochondrion outer membrane; Peripheral membrane protein. Note=Association with the Golgi apparatus depends on the cell type (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Microsome (GO:0005792) 15452144,11259440,11161816,15978591,15452144,12456676 cytoplasm 55 0 cytoplasm. mitochondrion multiple Bilateria Bilateria Opisthokonta SH3GLB2 HGNC:10834 SH3-domain GRB2-like endophilin B2 Q9NR46 Cytoplasm. Cytoplasm (GO:0005737) 11161816 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa SH3KBP1 HGNC:13867 SH3-domain kinase binding protein 1 Q96B97 Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion (By similarity). Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Cytoskeleton (GO:0005856); Cell projection (GO:0042995) 11071869,12177062,17081983,12829691,17081983,12218189,12618476,12771190,10858458,17255943 nucleus 25 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Tetrapoda Euteleostomi Eukaryota SH3PXD2A HGNC:23664 SH3 and PX domains 2A Q5TCZ1 Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. Nucleus (GO:0005634) 17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta SH3PXD2B HGNC:29242 SH3 and PX domains 2B A1X283 Cytoplasm (By similarity). Cell projection, podosome (By similarity). Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells (By similarity). cytoplasm 21 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota SH3RF1 HGNC:17650 SH3 domain containing ring finger 1 Q7Z6J0 Cytoplasm, perinuclear region (By similarity). Cell projection, lamellipodium. Cytoplasm. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans- Golgi network. cytoplasm 38 0 cytoplasm. golgi apparatus multiple Deuterostomia Bilateria Eukaryota SH3RF2 HGNC:26299 SH3 domain containing ring finger 2 Q8TEC5 cytoplasm 29 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota SH3RF3 HGNC:24699 SH3 domain containing ring finger 3 Q8TEJ3 cytoplasm 33 0 cytoplasm cytoplasm Chordata Chordata Eukaryota SH3TC1 HGNC:26009 SH3 domain and tetratricopeptide repeats 1 Q8TE82 cytoplasm 34 2 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms SH3TC2 HGNC:29427 SH3 domain and tetratricopeptide repeats 2 Q8TF17 nucleus 35 2 nucleus nucleus Amniota Euteleostomi Cell.Organisms SH3YL1 HGNC:29546 SH3 and SYLF domain containing 1 Q96HL8 cytoplasm 40 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms SHANK1 HGNC:15474 SH3 and multiple ankyrin repeat domains 1 Q9Y566 Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity). Cytoplasm (GO:0005737) 10806096 cytoplasm 18 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms SHANK2 HGNC:14295 SH3 and multiple ankyrin repeat domains 2 Q9UPX8 Cytoplasm (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Cytoplasm, postsynaptic density of neuronal cells (By similarity). Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 9742101,9742101 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms SHANK3 HGNC:14294 SH3 and multiple ankyrin repeat domains 3 Q9BYB0 Cytoplasm (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Postsynaptic density of neuronal cells (By similarity). Dendrite (GO:0030425); Cytoplasm (GO:0005737); Postsynaptic density (GO:0014069) 10506216,10506216,10806096 plasma membrane 25 0 cytoplasm cytoplasm NA NA Cell.Organisms SHARPIN HGNC:25321 SHANK-associated RH domain interactor Q9H0F6 Cytoplasm, cytosol. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11178875,11178875 cytoplasm 100 0 cytoplasm cytoplasm Theria Euteleostomi Eumetazoa SHB HGNC:10838 Src homology 2 domain containing adaptor protein B Q15464 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation. Cytoplasm (GO:0005737) 7713524 cytoplasm 20 0 cytoplasm cytoplasm Tetrapoda Bilateria Holozoa SHBG HGNC:10839 sex hormone-binding globulin P04278 Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity). Extracellular (GO:0005576) 10419028,16188874 secreted 60 0 secreted secreted Mammalia Euteleostomi Bilateria SHC1 HGNC:10840 SHC (Src homology 2 domain containing) transforming protein 1 P29353 Cytoplasm. Isoform p46Shc: Mitochondrion matrix. Isoform p66Shc: Mitochondrion (By similarity). Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum membrane (GO:0005789) 14676841,16113100,8628261,11302736,10971656,10457218,8628261 cytoplasm 27 0 cytoplasm. endoplasmic reticulum membrane. mitochondrion multiple Theria Bilateria Holozoa SHC2 HGNC:29869 SHC (Src homology 2 domain containing) transforming protein 2 P98077 cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa SHC3 HGNC:18181 SHC (Src homology 2 domain containing) transforming protein 3 Q92529 Cytoplasm (GO:0005737) 11877420 cytoplasm 36 0 cytoplasm cytoplasm Theria Theria Holozoa SHC4 HGNC:16743 SHC (Src homology 2 domain containing) family, member 4 Q6S5L8 Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction (By similarity). Cytosol (GO:0005829); Unknown membrane (None) 17409413,17409413 cytoplasm 49 0 cytoplasm cytoplasm Theria Amniota Holozoa SHCBP1 HGNC:29547 SHC SH2-domain binding protein 1 Q8NEM2 cytoplasm 55 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms SHCBP1L HGNC:16788 SHC SH2-domain binding protein 1-like Q9BZQ2 cytoplasm 36 0 cytoplasm cytoplasm Mammalia Chordata Cell.Organisms SHD HGNC:30633 Src homology 2 domain containing transforming protein D Q96IW2 cytoplasm 21 0 cytoplasm cytoplasm Mammalia Euteleostomi Holozoa SHE HGNC:27004 Src homology 2 domain containing E Q5VZ18 cytoplasm 25 0 cytoplasm cytoplasm Theria Euteleostomi Holozoa SHF HGNC:25116 Src homology 2 domain containing F Q7M4L6 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa SHFM1 HGNC:10845 split hand/foot malformation (ectrodactyly) type 1 P60896 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10373512,10373512 nucleus 58 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa SHH HGNC:10848 sonic hedgehog Q15465 Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity). Note=The N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid- modified N- and C-termini buried inside (By similarity). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 12421920,11576188 secreted 56 0 secreted secreted Bilateria Bilateria Metazoa SHISA2 HGNC:20366 shisa family member 2 Q6UWI4 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 79 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Deuterostomia SHISA3 HGNC:25159 shisa family member 3 A0PJX4 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). endoplasmic reticulum membrane 50 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Bilateria SHISA4 HGNC:27139 shisa family member 4 Q96DD7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 35 1 secreted secreted Mammalia Euteleostomi Bilateria SHISA5 HGNC:30376 shisa family member 5 Q8N114 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus membrane. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12135983,12135983 nucleus 15 1 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Amniota Euteleostomi Mammalia SHISA6 HGNC:34491 shisa family member 6 Q6ZSJ9 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 15 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Craniata SHISA7 HGNC:35409 shisa family member 7 A6NL88 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 27 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Euteleostomi Craniata SHISA8 HGNC:18351 shisa family member 8 B8ZZ34 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 16 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Craniata SHISA9 HGNC:37231 shisa family member 9 B4DS77 Cell projection, dendritic spine membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). endoplasmic reticulum membrane 16 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Craniata SHKBP1 HGNC:19214 SH3KBP1 binding protein 1 Q8TBC3 endoplasmic reticulum 28 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota SHMT1 HGNC:10850 serine hydroxymethyltransferase 1 (soluble) P34896 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11516159,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms SHMT2 HGNC:10852 serine hydroxymethyltransferase 2 (mitochondrial) P34897 Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane. Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 11516159,8505317,15635413 cytoplasm 57 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms SHOC2 HGNC:15454 soc-2 suppressor of clear homolog (C. elegans) Q9UQ13 Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. Cytoplasm (GO:0005737) 9618511 plasma membrane 16 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SHOX HGNC:10853 short stature homeobox O15266 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11751690,12784295,15292358 nucleus 61 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SHOX2 HGNC:10854 short stature homeobox 2 O60902 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SHPK HGNC:1492 sedoheptulokinase Q9UHJ6 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10673275 cytoplasm 84 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms SHPRH HGNC:19336 SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase Q149N8 Nucleus (GO:0005634) 12837266 nucleus 39 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms SHQ1 HGNC:25543 SHQ1, H/ACA ribonucleoprotein assembly factor Q6PI26 Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites. nucleus 12 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SHROOM1 HGNC:24084 shroom family member 1 Q2M3G4 Cytoplasm, cytoskeleton (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Eutheria Eutheria Euteleostomi SHROOM2 HGNC:630 shroom family member 2 Q13796 Apical cell membrane (By similarity). Cell junction, tight junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associates with cortical F-actin (By similarity). cytoplasm 52 0 cytoplasm cytoplasm Mammalia Euteleostomi Holozoa SHROOM3 HGNC:30422 shroom family member 3 Q8TF72 Cell junction, adherens junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with F-actin in stress fibers and adherens junctions (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10589677,10589677,17081983 cytoplasm 50 0 cytoplasm. nucleus multiple Human Deuterostomia Metazoa SHROOM4 HGNC:29215 shroom family member 4 Q9ULL8 Cytoplasm, cytoskeleton. Note=Shows partial colocalization with the cytoplasmic pool of F-actin. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Euteleostomi NA SI HGNC:10856 sucrase-isomaltase (alpha-glucosidase) P14410 Apical cell membrane; Single-pass type II membrane protein. Note=Brush border. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11003604,3896809,3925457,9092938 plasma membrane 100 1 endoplasmic reticulum. golgi apparatus. lysosome. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms SIAE HGNC:18187 sialic acid acetylesterase Q9HAT2 Lysosome (Probable). Secreted. Cytoplasm (GO:0005737) 10464298 secreted 66 0 cytoplasm. lysosome. secreted multiple Theria Cell.Organisms Cell.Organisms SIAH1 HGNC:10857 siah E3 ubiquitin protein ligase 1 Q8IUQ4 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Membrane fraction (GO:0005624); Endosome (GO:0005768); Cytosol (GO:0005829) 15951807,9334332,14506261,9858595,9403064,14654780,15951807,11786535,11786535,11786535 cytoplasm 77 0 cytoplasm. endosome. nucleus multiple Bilateria Eukaryota Eukaryota SIAH2 HGNC:10858 siah E3 ubiquitin protein ligase 2 O43255 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. Cytoplasm (GO:0005737) 9403064 cytoplasm 84 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SIAH3 HGNC:30553 siah E3 ubiquitin protein ligase family member 3 Q8IW03 cytoplasm 42 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota SIDT1 HGNC:25967 SID1 transmembrane family, member 1 Q9NXL6 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 10 11 plasma membrane plasma membrane Euteleostomi Eukaryota Eukaryota SIDT2 HGNC:24272 SID1 transmembrane family, member 2 Q8NBJ9 Lysosome membrane; Multi-pass membrane protein. Cytoplasm (GO:0005737) 17081983 plasma membrane 15 11 cytoplasm. lysosome membrane multiple Euteleostomi Eukaryota Eukaryota SIGIRR HGNC:30575 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Q6IA17 Membrane; Single-pass type III membrane protein (Potential). Plasma membrane (GO:0005886) 10346978,11022119 cytoplasm 22 1 plasma membrane plasma membrane Eutheria Euteleostomi Eumetazoa SIGLEC1 HGNC:11127 sialic acid binding Ig-like lectin 1, sialoadhesin Q9BZZ2 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886) 11133773 secreted 14 0 plasma membrane. secreted multiple Mammalia Tetrapoda Cell.Organisms SIGLEC10 HGNC:15620 sialic acid binding Ig-like lectin 10 Q96LC7 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 4: Cell membrane; Single-pass type I membrane protein. Isoform 5: Secreted. Plasma membrane (GO:0005886) 11358961 plasma membrane 35 1 plasma membrane. secreted multiple Theria Theria Metazoa SIGLEC11 HGNC:15622 sialic acid binding Ig-like lectin 11 Q96RL6 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11986327 plasma membrane 32 1 plasma membrane plasma membrane Theria Theria Metazoa SIGLEC12 HGNC:15482 sialic acid binding Ig-like lectin 12 (gene/pseudogene) Q96PQ1 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 11328818,11409877 plasma membrane 45 1 plasma membrane plasma membrane NA NA Metazoa SIGLEC14 HGNC:32926 sialic acid binding Ig-like lectin 14 Q08ET2 Cell membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 17012248 plasma membrane 100 1 plasma membrane plasma membrane NA NA Bilateria SIGLEC15 HGNC:27596 sialic acid binding Ig-like lectin 15 Q6ZMC9 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 14 1 plasma membrane plasma membrane Theria Euteleostomi Chordata SIGLEC16 HGNC:24851 sialic acid binding Ig-like lectin 16 (gene/pseudogene) A6NMB1 Membrane; Single-pass type I membrane protein. plasma membrane 32 1 plasma membrane plasma membrane Theria Theria Metazoa SIGLEC5 HGNC:10874 sialic acid binding Ig-like lectin 5 O15389 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9731071 plasma membrane 80 1 plasma membrane plasma membrane Eutheria Mammalia Metazoa SIGLEC6 HGNC:10875 sialic acid binding Ig-like lectin 6 O43699 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886) 10428856 plasma membrane 55 1 plasma membrane. secreted multiple Catarrhini Theria Metazoa SIGLEC7 HGNC:10876 sialic acid binding Ig-like lectin 7 Q9Y286 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10499918 plasma membrane 44 1 plasma membrane plasma membrane Catarrhini Mammalia Bilateria SIGLEC8 HGNC:10877 sialic acid binding Ig-like lectin 8 Q9NYZ4 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10856141 plasma membrane 48 1 plasma membrane plasma membrane Human Human Metazoa SIGLEC9 HGNC:10878 sialic acid binding Ig-like lectin 9 Q9Y336 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) 10801860 plasma membrane 46 1 plasma membrane plasma membrane Catarrhini Mammalia Bilateria SIGLECL1 HGNC:26856 SIGLEC family like 1 Q8N7X8 Membrane; Single-pass membrane protein (Potential). plasma membrane 43 1 plasma membrane plasma membrane Eutheria Eutheria Mammalia SIGMAR1 HGNC:8157 sigma non-opioid intracellular receptor 1 Q99720 Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding. Endoplasmic reticulum (GO:0005783); Nuclear membrane (GO:0005635); Plasma membrane (GO:0005886) 10406945,10406945,10406945 endoplasmic reticulum membrane 21 2 endoplasmic reticulum. lipid droplet. nucleus membrane. plasma membrane multiple Theria Eukaryota Cell.Organisms SIK1 HGNC:11142 salt-inducible kinase 1 P57059 Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) ,16306228,16306228 cytoplasm 61 0 cytoplasm. nucleus multiple Amniota Eukaryota Cell.Organisms SIK2 HGNC:21680 salt-inducible kinase 2 Q9H0K1 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 15511237 cytoplasm 88 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms SIK3 HGNC:29165 SIK family kinase 3 Q9Y2K2 Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. Nucleus (GO:0005634); Cytosol (GO:0005829) 15334068,16306228 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms SIKE1 HGNC:26119 suppressor of IKBKE 1 Q9BRV8 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa SIL1 HGNC:24624 SIL1 nucleotide exchange factor Q9H173 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 12356756,11101517 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Opisthokonta Eukaryota Eukaryota SIM1 HGNC:10882 single-minded family bHLH transcription factor 1 P81133 Nucleus (Potential). Nucleus (GO:0005634) 11782478 nucleus 64 0 nucleus nucleus Bilateria Bilateria Cell.Organisms SIM2 HGNC:10883 single-minded family bHLH transcription factor 2 Q14190 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11782478,14697214,14697214 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms SIMC1 HGNC:24779 SUMO-interacting motifs containing 1 Q8NDZ2 secreted 15 0 secreted secreted Theria Euteleostomi Craniata SIN3A HGNC:19353 SIN3 transcription regulator family member A Q96ST3 Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10441327,,10441327,15696166,11960000,11013263, nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota SIN3B HGNC:19354 SIN3 transcription regulator family member B O75182 Nucleus (By similarity). Nucleus (GO:0005634) 11959842 nucleus 91 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota SIPA1 HGNC:10885 signal-induced proliferation-associated 1 Q96FS4 Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region. Perinuclear region (GO:0048471); Nucleus (GO:0005634); Cytosol (GO:0005829); Cytoskeleton (GO:0005856); Membrane fraction (GO:0005624); Soluble fraction (GO:0005625); Cytoplasm (GO:0005737) 9346962,7799964,9183624,15456879,17081983,12590145,9346962,10373454,10373454,9346962,10373454,9346962,15456879,17081983 nucleus 86 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SIPA1L1 HGNC:20284 signal-induced proliferation-associated 1 like 1 O43166 Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). Nucleus (GO:0005634) 17081983 nucleus 39 0 nucleus nucleus Bilateria Bilateria Eukaryota SIPA1L2 HGNC:23800 signal-induced proliferation-associated 1 like 2 Q9P2F8 Nucleus (GO:0005634) 17081983 nucleus 39 0 nucleus nucleus Bilateria Bilateria Eukaryota SIPA1L3 HGNC:23801 signal-induced proliferation-associated 1 like 3 O60292 nucleus 38 0 nucleus nucleus Bilateria Bilateria Eukaryota SIRPA HGNC:9662 signal-regulatory protein alpha P78324 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9070220,15383453 plasma membrane 22 1 plasma membrane plasma membrane Amniota Amniota Cell.Organisms SIRPB1 HGNC:15928 signal-regulatory protein beta 1 O00241 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10604985 plasma membrane 20 1 plasma membrane plasma membrane Amniota Amniota Cell.Organisms SIRPB2 HGNC:16247 signal-regulatory protein beta 2 Q5JXA9 Membrane; Single-pass type I membrane protein (Potential). secreted 15 1 secreted secreted Catarrhini Eutheria Metazoa SIRPD HGNC:16248 signal-regulatory protein delta Q9H106 Secreted (Potential). plasma membrane 70 1 plasma membrane plasma membrane Eutheria Euteleostomi Craniata SIRPG HGNC:15757 signal-regulatory protein gamma Q9P1W8 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11185750 secreted 19 1 plasma membrane plasma membrane Human Human Cell.Organisms SIRT1 HGNC:14929 sirtuin 1 Q96EB6 Nucleus, PML body. Cytoplasm. SirtT1 75 kDa fragment: Cytoplasm. Mitochondrion. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12006491,17081983,17081983 nucleus 33 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms SIRT2 HGNC:10886 sirtuin 2 Q8IXJ6 Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Cytoplasm (GO:0005737);Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983/12620231,12620231,10393250,12697818,17081983,12620231,10393250 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SIRT3 HGNC:14931 sirtuin 3 Q9NTG7 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 12374852,12186850,12186850,11056054 mitochondrion 100 0 cytoplasm. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms SIRT4 HGNC:14932 sirtuin 4 Q9Y6E7 Mitochondrion matrix. Nucleus (GO:0005634) mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms SIRT5 HGNC:14933 sirtuin 5 Q9NXA8 Mitochondrion matrix. Mitochondrion intermembrane space. Isoform 1: Cytoplasm. Mitochondrion. Isoform 2: Mitochondrion. Nucleus (GO:0005634) mitochondrion 83 0 cytoplasm. mitochondrion multiple Euteleostomi Cell.Organisms Cell.Organisms SIRT6 HGNC:14934 sirtuin 6 Q8N6T7 Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions. Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 nucleus 100 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms SIRT7 HGNC:14935 sirtuin 7 Q9NRC8 Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis. Nucleus (GO:0005634) nucleus 32 0 cytoplasm. nucleus multiple Deuterostomia Opisthokonta Cell.Organisms SIT1 HGNC:17710 signaling threshold regulating transmembrane adaptor 1 Q9Y3P8 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10209036 plasma membrane 100 1 plasma membrane plasma membrane Eutheria Mammalia Mammalia SIVA1 HGNC:17712 SIVA1, apoptosis-inducing factor O15304 Cytoplasm. Nucleus. Note=In the nucleus, accumulates in dot-like structures. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 15105421,15105421 nucleus 45 0 cytoplasm. mitochondrion. nucleus multiple Chordata Chordata Eumetazoa SIX1 HGNC:10887 SIX homeobox 1 Q15475 Nucleus. Cytoplasm. Nucleus (GO:0005634) 10801845,15492887 nucleus 77 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SIX2 HGNC:10888 SIX homeobox 2 Q9NPC8 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota SIX3 HGNC:10889 SIX homeobox 3 O95343 Nucleus. Nucleus (GO:0005634) 9889003 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota SIX4 HGNC:10890 SIX homeobox 4 Q9UIU6 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8628654,8628654 nucleus 60 0 cytoplasm. nucleus multiple Theria Bilateria Opisthokonta SIX5 HGNC:10891 SIX homeobox 5 Q8N196 Cytoplasm. Nucleus. Nucleus (GO:0005634) nucleus 50 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Opisthokonta SIX6 HGNC:10892 SIX homeobox 6 O95475 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 77 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SKA1 HGNC:28109 spindle and kinetochore associated complex subunit 1 Q96BD8 Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid- anaphase and then vanishes in telophase. Kinetochore (GO:0000776); Microtubule (GO:0005874); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17093495,17093495,17093495,17093495 nucleus 53 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota NA SKA2 HGNC:28006 spindle and kinetochore associated complex subunit 2 Q8WVK7 Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Kinetochore (GO:0000776) 17093495 nucleus 49 0 cytoplasm. nucleus multiple Amniota Euteleostomi Holozoa SKA3 HGNC:20262 spindle and kinetochore associated complex subunit 3 Q8IX90 Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. nucleus 57 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Euteleostomi SKAP1 HGNC:15605 src kinase associated phosphoprotein 1 Q86WV1 Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11909961,11909961 cytoplasm 35 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SKAP2 HGNC:15687 src kinase associated phosphoprotein 2 O75563 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9671755,11063873,12893833,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Eukaryota SKI HGNC:10896 v-ski avian sarcoma viral oncogene homolog P12755 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10549282,8514802,11719430 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eumetazoa SKIDA1 HGNC:32697 SKI/DACH domain containing 1 Q1XH10 nucleus 13 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa SKIL HGNC:10897 SKI-like oncogene P12757 Nucleus (GO:0005634) 10531062 nucleus 31 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa SKIV2L HGNC:10898 superkiller viralicidic activity 2-like (S. cerevisiae) Q15477 Nucleus (Probable). Cytoplasm (Probable). Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Ribosome (GO:0005840); Nucleus (GO:0005634) 9705521,9705521,11487501,17081983,9705521,11487501,17081983 cytoplasm 28 0 cytoplasm. nucleus multiple Theria Eukaryota NA SKIV2L2 HGNC:18734 superkiller viralicidic activity 2-like 2 (S. cerevisiae) P42285 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) none,15561729,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms SKOR1 HGNC:21326 SKI family transcriptional corepressor 1 P84550 Nucleus (By similarity). Nucleus (GO:0005634) 15528197 nucleus 89 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa SKOR2 HGNC:32695 SKI family transcriptional corepressor 2 Q2VWA4 Nucleus. Cytoplasm. nucleus 86 0 cytoplasm. nucleus multiple Theria Bilateria Eumetazoa SKP1 HGNC:10899 S-phase kinase-associated protein 1 P63208 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730) 11359933,11359933,15635413 nucleus 20 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SKP2 HGNC:10901 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase Q13309 Cytoplasm. Nucleus. Nucleus (GO:0005634) 9430629,7553852 nucleus 24 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms SLA HGNC:10902 Src-like-adaptor Q13239 Cytoplasm (By similarity). Endosome (By similarity). Note=Colocalizes with endosomes (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10779329,10779329,10779329 cytoplasm 17 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Holozoa SLA2 HGNC:17329 Src-like-adaptor 2 Q9H6Q3 Cytoplasm. Isoform 1: Cell membrane. Cytoplasmic vesicle. Isoform 2: Cytoplasm (Probable). Note=May be cytoplasmic and is not localized to membranes. Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Intracellular vesicle (None) 12024036,11696592,12024036,11696592,12024036,12024036 cytoplasm 22 0 cytoplasm. endosome multiple Theria Euteleostomi Holozoa SLAIN1 HGNC:26387 SLAIN motif family, member 1 Q8ND83 cytoplasm 29 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Craniata SLAIN2 HGNC:29282 SLAIN motif family, member 2 Q9P270 Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata SLAMF1 HGNC:10903 signaling lymphocytic activation molecule family member 1 Q13291 Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Plasma membrane (GO:0005886) 11806999,11544303 plasma membrane 100 1 plasma membrane plasma membrane Amniota Amniota Craniata SLAMF6 HGNC:21392 SLAM family member 6 Q96DU3 Cell membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 11489943 plasma membrane 15 1 plasma membrane plasma membrane Eutheria Eutheria Chordata SLAMF7 HGNC:21394 SLAM family member 7 Q9NQ25 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11220635,11698418 plasma membrane 18 1 plasma membrane plasma membrane Eutheria Mammalia Mammalia SLAMF8 HGNC:21391 SLAM family member 8 Q9P0V8 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11313408 plasma membrane 11 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Euteleostomi SLAMF9 HGNC:18430 SLAM family member 9 Q96A28 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 20 1 plasma membrane plasma membrane Mammalia Tetrapoda Euteleostomi SLBP HGNC:10904 stem-loop binding protein Q14493 Cytoplasm. Nucleus. Note=Polyribosome- associated. Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Ribosome (GO:0005840) 12415002,12415002,17081983,8652556 cytoplasm 27 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota SLC10A1 HGNC:10905 solute carrier family 10 (sodium/bile acid cotransporter), member 1 Q14973 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11802798 plasma membrane 26 9 plasma membrane plasma membrane Theria Bilateria Cell.Organisms SLC10A2 HGNC:10906 solute carrier family 10 (sodium/bile acid cotransporter), member 2 Q12908 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9109432 golgi apparatus membrane 14 9 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC10A3 HGNC:22979 solute carrier family 10, member 3 P09131 Membrane; Multi-pass membrane protein (Probable). plasma membrane 45 10 plasma membrane plasma membrane Mammalia Cell.Organisms NA SLC10A4 HGNC:22980 solute carrier family 10, member 4 Q96EP9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 38 9 cytoplasm cytoplasm Chordata Chordata Cell.Organisms SLC10A5 HGNC:22981 solute carrier family 10, member 5 Q5PT55 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 42 9 plasma membrane plasma membrane NA NA Cell.Organisms SLC10A6 HGNC:30603 solute carrier family 10 (sodium/bile acid cotransporter), member 6 Q3KNW5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 45 9 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC10A7 HGNC:23088 solute carrier family 10, member 7 Q0GE19 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 37 9 golgi apparatus membrane golgi apparatus membrane Deuterostomia Cell.Organisms Cell.Organisms SLC11A1 HGNC:10907 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 P49279 Membrane; Multi-pass membrane protein (Probable). Endosome (GO:0005768); Lysosome (GO:0005764); Integral to plasma membrane (GO:0005887) 9034150,9271100,10049947,8537108,9271100 vacuole membrane 40 12 endosome. lysosome. plasma membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms SLC11A2 HGNC:10908 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 P49281 Endosome membrane; Multi-pass membrane protein. Endosome (GO:0005768); Lysosome (GO:0005764); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10751401,12475959,11095929,10751401,12475959,11891802,11755534,11891802,11755534,11095929,10751401 vacuole membrane 42 12 cytoplasm. endosome. endosome membrane. lysosome. nucleus. plasma membrane multiple Cell.Organisms Cell.Organisms Cell.Organisms SLC12A1 HGNC:10910 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 Q13621 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9672238 plasma membrane 43 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC12A2 HGNC:10911 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 P55011 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10736171,11042348 plasma membrane 45 12 plasma membrane. secreted multiple Bilateria Cell.Organisms Cell.Organisms SLC12A3 HGNC:10912 solute carrier family 12 (sodium/chloride transporter), member 3 P55017 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11832422 plasma membrane 100 14 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC12A4 HGNC:10913 solute carrier family 12 (potassium/chloride transporter), member 4 Q9UP95 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8663127 plasma membrane 73 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC12A5 HGNC:13818 solute carrier family 12 (potassium/chloride transporter), member 5 Q9H2X9 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 68 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC12A6 HGNC:10914 solute carrier family 12 (potassium/chloride transporter), member 6 Q9UHW9 Basolateral cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10600773 plasma membrane 98 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC12A7 HGNC:10915 solute carrier family 12 (potassium/chloride transporter), member 7 Q9Y666 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11976689,14698746 plasma membrane 100 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC12A8 HGNC:15595 solute carrier family 12, member 8 A0AV02 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12739168 plasma membrane 17 12 plasma membrane plasma membrane NA NA Cell.Organisms SLC12A9 HGNC:17435 solute carrier family 12, member 9 Q9BXP2 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10871601 plasma membrane 100 13 plasma membrane plasma membrane Opisthokonta Opisthokonta Cell.Organisms SLC13A1 HGNC:10916 solute carrier family 13 (sodium/sulfate symporter), member 1 Q9BZW2 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12867358 plasma membrane 30 13 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLC13A2 HGNC:10917 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Q13183 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 8967342 plasma membrane 33 13 plasma membrane plasma membrane Bilateria Eukaryota NA SLC13A3 HGNC:14430 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 Q8WWT9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 10992006 plasma membrane 100 13 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC13A4 HGNC:15827 solute carrier family 13 (sodium/sulfate symporter), member 4 Q9UKG4 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 25 12 plasma membrane plasma membrane Chordata Chordata Cell.Organisms SLC13A5 HGNC:23089 solute carrier family 13 (sodium-dependent citrate transporter), member 5 Q86YT5 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 40 13 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC14A1 HGNC:10918 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) Q13336 Cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane (By similarity). Plasma membrane (GO:0005886) 9582331,7989337 plasma membrane 55 10 plasma membrane plasma membrane Human Eutheria Cell.Organisms SLC14A2 HGNC:10919 solute carrier family 14 (urea transporter), member 2 Q15849 Apical cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) ,12952854 plasma membrane 100 20 plasma membrane plasma membrane Mammalia Eukaryota Cell.Organisms SLC15A1 HGNC:10920 solute carrier family 15 (oligopeptide transporter), member 1 P46059 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Cytoplasmic vesicle (GO:0016023) 9207295,9115234,9458100 plasma membrane 36 12 lysosome. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms SLC15A2 HGNC:10921 solute carrier family 15 (oligopeptide transporter), member 2 Q16348 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7756356 plasma membrane 32 13 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms SLC15A3 HGNC:18068 solute carrier family 15 (oligopeptide transporter), member 3 Q8IY34 Lysosome membrane; Multi-pass membrane protein. Lysosome (GO:0005764) 11336635 vacuole membrane 14 12 lysosome. lysosome membrane multiple Theria Theria Cell.Organisms SLC15A4 HGNC:23090 solute carrier family 15 (oligopeptide transporter), member 4 Q8N697 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 16 12 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms SLC15A5 HGNC:33455 solute carrier family 15, member 5 A6NIM6 Membrane; Multi-pass membrane protein (Potential). plasma membrane 7 12 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms SLC16A1 HGNC:10922 solute carrier family 16 (monocarboxylate transporter), member 1 P53985 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 8124722,10562613,17081983 plasma membrane 100 12 mitochondrion. nucleus. plasma membrane multiple Chordata Cell.Organisms Cell.Organisms SLC16A10 HGNC:17027 solute carrier family 16 (aromatic amino acid transporter), member 10 Q8TF71 Cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane (By similarity). Plasma membrane (GO:0005886) plasma membrane 42 12 plasma membrane plasma membrane Deuterostomia Opisthokonta Cell.Organisms SLC16A11 HGNC:23093 solute carrier family 16, member 11 Q8NCK7 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 25 11 plasma membrane plasma membrane Theria Theria Eukaryota SLC16A12 HGNC:23094 solute carrier family 16, member 12 Q6ZSM3 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 20 12 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms SLC16A13 HGNC:31037 solute carrier family 16, member 13 Q7RTY0 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 21 12 plasma membrane plasma membrane Euarchontoglires Cell.Organisms Cell.Organisms SLC16A14 HGNC:26417 solute carrier family 16, member 14 Q7RTX9 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 12 12 plasma membrane plasma membrane Theria Bilateria Cell.Organisms SLC16A2 HGNC:10923 solute carrier family 16, member 2 (thyroid hormone transporter) P36021 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 9545634 plasma membrane 91 12 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms SLC16A3 HGNC:10924 solute carrier family 16 (monocarboxylate transporter), member 3 O15427 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10510291,9425115 plasma membrane 100 12 plasma membrane plasma membrane Euteleostomi Opisthokonta Cell.Organisms SLC16A4 HGNC:10925 solute carrier family 16, member 4 O15374 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10510291 plasma membrane 100 12 plasma membrane plasma membrane Deuterostomia Deuterostomia Cell.Organisms SLC16A5 HGNC:10926 solute carrier family 16 (monocarboxylate transporter), member 5 O15375 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10510291,9425115 plasma membrane 100 12 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLC16A6 HGNC:10927 solute carrier family 16, member 6 O15403 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10510291,17081983 plasma membrane 100 12 nucleus. plasma membrane multiple Euteleostomi Euteleostomi NA SLC16A7 HGNC:10928 solute carrier family 16 (monocarboxylate transporter), member 7 O60669 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9786900,12115955 plasma membrane 100 12 plasma membrane plasma membrane Chordata Cell.Organisms Cell.Organisms SLC16A8 HGNC:16270 solute carrier family 16 (monocarboxylate transporter), member 8 O95907 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12657613 plasma membrane 100 12 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota SLC16A9 HGNC:23520 solute carrier family 16, member 9 Q7RTY1 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 22 12 plasma membrane plasma membrane Chordata Chordata Cell.Organisms SLC17A1 HGNC:10929 solute carrier family 17 (organic anion transporter), member 1 Q14916 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10733936 mitochondrion membrane 14 12 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms SLC17A2 HGNC:10930 solute carrier family 17, member 2 O00624 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) mitochondrion membrane 19 11 mitochondrion membrane mitochondrion membrane Theria Theria Cell.Organisms SLC17A3 HGNC:10931 solute carrier family 17 (organic anion transporter), member 3 O00476 Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Isoform 2: Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9149941 mitochondrion membrane 15 10 endoplasmic reticulum membrane. plasma membrane multiple Human Deuterostomia Cell.Organisms SLC17A4 HGNC:10932 solute carrier family 17, member 4 Q9Y2C5 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) mitochondrion membrane 17 12 mitochondrion membrane mitochondrion membrane Human Euteleostomi Cell.Organisms SLC17A5 HGNC:10933 solute carrier family 17 (acidic sugar transporter), member 5 Q9NRA2 Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane; Multi-pass membrane protein. Lysosome (GO:0005764) 11588980 mitochondrion membrane 24 12 lysosome. lysosome membrane. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC17A6 HGNC:16703 solute carrier family 17 (vesicular glutamate transporter), member 6 Q9P2U8 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity). Integral to membrane (GO:0016021) mitochondrion membrane 21 12 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms SLC17A7 HGNC:16704 solute carrier family 17 (vesicular glutamate transporter), member 7 Q9P2U7 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity). Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 8632143,11001057 mitochondrion membrane 23 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC17A8 HGNC:20151 solute carrier family 17 (vesicular glutamate transporter), member 8 Q8NDX2 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity). Integral to membrane (GO:0016021) mitochondrion membrane 22 12 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms SLC17A9 HGNC:16192 solute carrier family 17 (vesicular nucleotide transporter), member 9 Q9BYT1 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 16 12 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms SLC18A1 HGNC:10934 solute carrier family 18 (vesicular monoamine transporter), member 1 P54219 Isoform 1: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11431013,11431013 plasma membrane 14 12 cytoplasm. endoplasmic reticulum membrane. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC18A2 HGNC:10935 solute carrier family 18 (vesicular monoamine transporter), member 2 Q05940 Cytoplasmic vesicle membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 11431013,11431013,12009896 plasma membrane 19 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC18A3 HGNC:10936 solute carrier family 18 (vesicular acetylcholine transporter), member 3 Q16572 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 8071310,8071310 mitochondrion membrane 5 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC18B1 HGNC:21573 solute carrier family 18, subfamily B, member 1 Q6NT16 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 48 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC19A1 HGNC:10937 solute carrier family 19 (folate transporter), member 1 P41440 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12227830,12087110 plasma membrane 76 12 plasma membrane plasma membrane Tetrapoda Bilateria Eukaryota SLC19A2 HGNC:10938 solute carrier family 19 (thiamine transporter), member 2 O60779 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10391223 endoplasmic reticulum membrane 54 12 plasma membrane plasma membrane Bilateria Bilateria Eukaryota SLC19A3 HGNC:16266 solute carrier family 19 (thiamine transporter), member 3 Q9BZV2 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 59 12 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota SLC1A1 HGNC:10939 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 P43005 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10701825,10701825 golgi apparatus membrane 30 10 cytoplasm. plasma membrane multiple Deuterostomia Cell.Organisms Cell.Organisms SLC1A2 HGNC:10940 solute carrier family 1 (glial high affinity glutamate transporter), member 2 P43004 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11860269 golgi apparatus membrane 22 10 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC1A3 HGNC:10941 solute carrier family 1 (glial high affinity glutamate transporter), member 3 P43003 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 10594060,10594060 plasma membrane 21 10 nucleus. plasma membrane multiple Chordata Bilateria Cell.Organisms SLC1A4 HGNC:10942 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 P43007 Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10933718,11268453 golgi apparatus membrane 27 10 cytoplasm. melanosome. plasma membrane multiple Euteleostomi Cell.Organisms Cell.Organisms SLC1A5 HGNC:10943 solute carrier family 1 (neutral amino acid transporter), member 5 Q15758 Membrane; Multi-pass membrane protein (Probable). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886) 12175968 golgi apparatus membrane 44 10 melanosome. plasma membrane multiple Theria Cell.Organisms Cell.Organisms SLC1A6 HGNC:10944 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 P48664 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7791878 plasma membrane 17 10 plasma membrane plasma membrane Chordata Bilateria Cell.Organisms SLC1A7 HGNC:10945 solute carrier family 1 (glutamate transporter), member 7 O00341 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) golgi apparatus membrane 13 10 golgi apparatus membrane golgi apparatus membrane Human Euteleostomi Cell.Organisms SLC20A1 HGNC:10946 solute carrier family 20 (phosphate transporter), member 1 Q8WUM9 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8041748 plasma membrane 56 10 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms SLC20A2 HGNC:10947 solute carrier family 20 (phosphate transporter), member 2 Q08357 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8302848 plasma membrane 100 10 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms SLC22A1 HGNC:10963 solute carrier family 22 (organic cation transporter), member 1 O15245 Basolateral cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 9187257 plasma membrane 100 12 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms SLC22A10 HGNC:18057 solute carrier family 22, member 10 Q63ZE4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12372408 plasma membrane 37 12 plasma membrane plasma membrane Theria Theria Cell.Organisms SLC22A11 HGNC:18120 solute carrier family 22 (organic anion/urate transporter), member 11 Q9NSA0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10660625,18985008 plasma membrane 100 12 plasma membrane plasma membrane Homininae Euteleostomi Cell.Organisms SLC22A12 HGNC:17989 solute carrier family 22 (organic anion/urate transporter), member 12 Q96S37 Cell membrane; Multi-pass membrane protein. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules. Plasma membrane (GO:0005886) 12024214 plasma membrane 100 12 plasma membrane plasma membrane Mammalia Mammalia Cell.Organisms SLC22A13 HGNC:8494 solute carrier family 22 (organic anion/urate transporter), member 13 Q9Y226 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10072596 plasma membrane 21 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC22A14 HGNC:8495 solute carrier family 22, member 14 Q9Y267 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10072596 plasma membrane 12 12 plasma membrane plasma membrane Theria Opisthokonta Cell.Organisms SLC22A15 HGNC:20301 solute carrier family 22, member 15 Q8IZD6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12372408 plasma membrane 17 12 plasma membrane plasma membrane Chordata Chordata Cell.Organisms SLC22A16 HGNC:20302 solute carrier family 22 (organic cation/carnitine transporter), member 16 Q86VW1 Membrane; Multi-pass membrane protein (Potential). Cell membrane. Note=Detected in the plasma mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis. Plasma membrane (GO:0005886) 12089149 plasma membrane 16 12 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLC22A17 HGNC:23095 solute carrier family 22, member 17 Q8WUG5 Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2- binding, it is internalized. Integral to membrane (GO:0016021) plasma membrane 10 11 plasma membrane. vacuole membrane multiple Theria Euteleostomi Cell.Organisms SLC22A18 HGNC:10964 solute carrier family 22, member 18 Q96BI1 Apical cell membrane; Multi-pass membrane protein (Potential). Note=Localized at the apical membrane surface of renal proximal tubules. Plasma membrane (GO:0005886) 9744804 plasma membrane 55 12 plasma membrane plasma membrane Eutheria Cell.Organisms Cell.Organisms SLC22A18AS HGNC:10965 solute carrier family 22 (organic cation transporter), member 18 antisense Q8N1D0 secreted 66 0 secreted secreted NA NA Euarchontoglires SLC22A2 HGNC:10966 solute carrier family 22 (organic cation transporter), member 2 O15244 Membrane; Multi-pass membrane protein (Potential). Basolateral membrane (GO:0016323) 12089365 plasma membrane 63 12 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms SLC22A23 HGNC:21106 solute carrier family 22, member 23 A1A5C7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 6 12 plasma membrane plasma membrane Tetrapoda Euteleostomi Cell.Organisms SLC22A24 HGNC:28542 solute carrier family 22, member 24 Q8N4F4 Membrane; Multi-pass membrane protein (Potential). plasma membrane 33 6 plasma membrane plasma membrane Homininae Homininae Cell.Organisms SLC22A25 HGNC:32935 solute carrier family 22, member 25 Q6T423 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 33 12 plasma membrane plasma membrane Theria Theria Cell.Organisms SLC22A3 HGNC:10967 solute carrier family 22 (organic cation transporter), member 3 O75751 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9933568 plasma membrane 38 12 plasma membrane plasma membrane Amniota Eukaryota Cell.Organisms SLC22A31 HGNC:27091 solute carrier family 22, member 31 A6NKX4 Membrane; Multi-pass membrane protein (Potential). plasma membrane 10 12 plasma membrane plasma membrane NA NA NA SLC22A4 HGNC:10968 solute carrier family 22 (organic cation/zwitterion transporter), member 4 Q9H015 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9703985,9808712 plasma membrane 67 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC22A5 HGNC:10969 solute carrier family 22 (organic cation/carnitine transporter), member 5 O76082 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9685390 plasma membrane 82 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC22A6 HGNC:10970 solute carrier family 22 (organic anion transporter), member 6 Q4U2R8 Cell membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12874449,16164645,14749323 plasma membrane 83 12 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms SLC22A7 HGNC:10971 solute carrier family 22 (organic anion transporter), member 7 Q9Y694 Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule. Plasma membrane (GO:0005886) 11907186 plasma membrane 100 12 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms SLC22A8 HGNC:10972 solute carrier family 22 (organic anion transporter), member 8 Q8TCC7 Basolateral cell membrane; Multi-pass membrane protein (Potential). Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). Plasma membrane (GO:0005886); Basolateral membrane (GO:0016323) 14729100,11855680 plasma membrane 37 12 plasma membrane plasma membrane Eutheria Opisthokonta Cell.Organisms SLC22A9 HGNC:16261 solute carrier family 22 (organic anion transporter), member 9 Q8IVM8 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 10660625 plasma membrane 31 12 plasma membrane plasma membrane Theria Theria Cell.Organisms SLC23A1 HGNC:10974 solute carrier family 23 (ascorbic acid transporter), member 1 Q9UHI7 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12388072,10395795 plasma membrane 100 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC23A2 HGNC:10973 solute carrier family 23 (ascorbic acid transporter), member 2 Q9UGH3 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15060139 plasma membrane 100 14 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC23A3 HGNC:20601 solute carrier family 23, member 3 Q6PIS1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 16 13 plasma membrane plasma membrane Human Human Cell.Organisms SLC24A1 HGNC:10975 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 O60721 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10662833 nucleus 27 11 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms SLC24A2 HGNC:10976 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 Q9UI40 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12525183 vacuole membrane 13 11 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms SLC24A3 HGNC:10977 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 Q9HC58 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) vacuole membrane 15 11 vacuole membrane vacuole membrane Deuterostomia Bilateria Cell.Organisms SLC24A4 HGNC:10978 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Q8NFF2 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12379639 vacuole membrane 13 11 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms SLC24A5 HGNC:20611 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 Q71RS6 Membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Enriched in late-stage melanosomes. Integral to membrane (GO:0016021) vacuole membrane 9 12 melanosome melanosome Euteleostomi Bilateria Cell.Organisms SLC25A1 HGNC:10979 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 P53007 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9254007,15598749 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Opisthokonta Eukaryota NA SLC25A10 HGNC:10980 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 Q9UBX3 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10585886,15598749 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple NA NA Cell.Organisms SLC25A11 HGNC:10981 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 Q02978 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 1457818,8769314,9639574 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Eukaryota SLC25A12 HGNC:10982 solute carrier family 25 (aspartate/glutamate carrier), member 12 O75746 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11566871,9722566,15598749,9722566 mitochondrion membrane 100 1 cytoplasm. mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Eukaryota SLC25A13 HGNC:10983 solute carrier family 25 (aspartate/glutamate carrier), member 13 Q9UJS0 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10642534,15561729 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Eukaryota SLC25A14 HGNC:10984 solute carrier family 25 (mitochondrial carrier, brain), member 14 O95258 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 11701769,9852133 mitochondrion membrane 75 3 mitochondrion mitochondrion Euteleostomi Eukaryota Eukaryota SLC25A15 HGNC:10985 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 Q9Y619 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10369256 mitochondrion membrane 100 4 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota Eukaryota SLC25A16 HGNC:10986 solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 P16260 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 11158296 mitochondrion membrane 100 5 mitochondrion. mitochondrion membrane multiple Deuterostomia Eukaryota Eukaryota SLC25A17 HGNC:10987 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 O43808 Cytoplasm. Peroxisome membrane; Multi-pass membrane protein. Peroxisome (GO:0005777) 9874197,11121399,11402059 peroxisome membrane 16 7 cytoplasm. peroxisome. peroxisome membrane multiple Euteleostomi Eukaryota Eukaryota SLC25A18 HGNC:10988 solute carrier family 25 (glutamate carrier), member 18 Q9H1K4 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 32 4 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota SLC25A19 HGNC:14409 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Q9HC21 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 11226231 mitochondrion membrane 100 5 mitochondrion. mitochondrion membrane multiple Opisthokonta Eukaryota Eukaryota SLC25A2 HGNC:22921 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 Q9BXI2 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 12948741 mitochondrion membrane 100 4 mitochondrion. mitochondrion membrane multiple Bilateria Eukaryota NA SLC25A20 HGNC:1421 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 O43772 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Peroxisome (GO:0005777); Endoplasmic reticulum (GO:0005783) 11592821,11257506,11257506 mitochondrion membrane 100 5 endoplasmic reticulum. mitochondrion. mitochondrion membrane. peroxisome multiple Bilateria Eukaryota Eukaryota SLC25A21 HGNC:14411 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 Q9BQT8 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) mitochondrion membrane 100 5 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Eukaryota SLC25A22 HGNC:19954 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 Q9H936 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) mitochondrion membrane 33 4 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota SLC25A23 HGNC:19375 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Q9BV35 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 15054102,15123600 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC25A24 HGNC:20662 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 Q6NUK1 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrial membrane (GO:0005740);Mitochondrial membrane (GO:0005740) 15123600/15054102 mitochondrion membrane 100 3 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Cell.Organisms SLC25A25 HGNC:20663 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 Q6KCM7 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 15054102,12645546,15123600 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Cell.Organisms SLC25A26 HGNC:20661 solute carrier family 25 (S-adenosylmethionine carrier), member 26 Q70HW3 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 14674884 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota NA SLC25A27 HGNC:21065 solute carrier family 25, member 27 O95847 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrial membrane (GO:0005740) 10025957,10928996 mitochondrion membrane 100 3 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota SLC25A28 HGNC:23472 solute carrier family 25 (mitochondrial iron transporter), member 28 Q96A46 Mitochondrion inner membrane; Multi-pass membrane protein. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion. Mitochondrion (GO:0005739) 11297739 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC25A29 HGNC:20116 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 Q8N8R3 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) mitochondrion membrane 100 4 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota SLC25A3 HGNC:10989 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 Q00325 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrial membrane (GO:0005740) 8144629 mitochondrion membrane 100 3 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota SLC25A30 HGNC:27371 solute carrier family 25, member 30 Q5SVS4 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 90 3 mitochondrion membrane mitochondrion membrane Euteleostomi Eukaryota Eukaryota SLC25A31 HGNC:25319 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Q9H0C2 Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region. Mitochondrion (GO:0005739) 15670820 mitochondrion membrane 68 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC25A32 HGNC:29683 solute carrier family 25 (mitochondrial folate carrier), member 32 Q9H2D1 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10978331,10978331 mitochondrion membrane 100 5 cytoplasm. mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC25A33 HGNC:29681 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 Q9BSK2 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 14715278 mitochondrion membrane 100 5 mitochondrion. mitochondrion membrane multiple Amniota Eukaryota Eukaryota SLC25A34 HGNC:27653 solute carrier family 25, member 34 Q6PIV7 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 18 3 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Eukaryota SLC25A35 HGNC:31921 solute carrier family 25, member 35 Q3KQZ1 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrial membrane (GO:0005740); Integral to membrane (GO:0016021) 16949250,16949250 mitochondrion membrane 23 3 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Eukaryota SLC25A36 HGNC:25554 solute carrier family 25 (pyrimidine nucleotide carrier ), member 36 Q96CQ1 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 52 5 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Cell.Organisms SLC25A37 HGNC:29786 solute carrier family 25 (mitochondrial iron transporter), member 37 Q9NYZ2 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 68 3 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota SLC25A38 HGNC:26054 solute carrier family 25, member 38 Q96DW6 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 19 3 mitochondrion membrane mitochondrion membrane Euteleostomi Eukaryota Eukaryota SLC25A39 HGNC:24279 solute carrier family 25, member 39 Q9BZJ4 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 11139402 mitochondrion membrane 100 5 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC25A4 HGNC:10990 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 P12235 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 8479824,15598749,12039962 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane. nucleus multiple Eukaryota Eukaryota Eukaryota SLC25A40 HGNC:29680 solute carrier family 25, member 40 Q8TBP6 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 11897791 mitochondrion membrane 38 5 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota SLC25A41 HGNC:28533 solute carrier family 25, member 41 Q8N5S1 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrial membrane (GO:0005740) 16949250 mitochondrion membrane 51 3 mitochondrion membrane mitochondrion membrane Theria Theria Eukaryota SLC25A42 HGNC:28380 solute carrier family 25, member 42 Q86VD7 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 5 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota SLC25A43 HGNC:30557 solute carrier family 25, member 43 Q8WUT9 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) mitochondrion membrane 15 3 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Eukaryota SLC25A44 HGNC:29036 solute carrier family 25, member 44 Q96H78 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 12 3 mitochondrion membrane mitochondrion membrane Theria Eukaryota Eukaryota SLC25A45 HGNC:27442 solute carrier family 25, member 45 Q8N413 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 30 4 mitochondrion membrane mitochondrion membrane Eutheria Euteleostomi Eukaryota SLC25A46 HGNC:25198 solute carrier family 25, member 46 Q96AG3 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrial membrane (GO:0005740) 16949250 peroxisome membrane 27 2 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Eukaryota SLC25A47 HGNC:20115 solute carrier family 25, member 47 Q6Q0C1 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 15322095,15322095 mitochondrion membrane 100 5 cytoplasm. mitochondrion. mitochondrion membrane multiple Euteleostomi Eukaryota Eukaryota SLC25A48 HGNC:30451 solute carrier family 25, member 48 Q6ZT89 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 27 4 mitochondrion membrane mitochondrion membrane Chordata Chordata Eukaryota SLC25A5 HGNC:10991 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 P05141 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9698557,15598749 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC25A51 HGNC:23323 solute carrier family 25, member 51 Q9H1U9 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) mitochondrion membrane 6 4 mitochondrion membrane mitochondrion membrane Theria Bilateria Eukaryota SLC25A52 HGNC:23324 solute carrier family 25, member 52 Q3SY17 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739) mitochondrion membrane 7 4 mitochondrion membrane mitochondrion membrane Homininae Homininae Eukaryota SLC25A53 HGNC:31894 solute carrier family 25, member 53 Q5H9E4 Mitochondrion inner membrane; Multi-pass membrane protein (Potential). Mitochondrial membrane (GO:0005740) mitochondrion membrane 7 3 mitochondrion membrane mitochondrion membrane Mammalia Euteleostomi Eukaryota SLC25A6 HGNC:10992 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 P12236 Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria (By similarity). Mitochondrion (GO:0005739) 8486369,15598749 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota SLC26A1 HGNC:10993 solute carrier family 26 (anion exchanger), member 1 Q9H2B4 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 11087667,12713736 plasma membrane 20 12 plasma membrane plasma membrane Chordata Bilateria Cell.Organisms SLC26A10 HGNC:14470 solute carrier family 26, member 10 Q8NG04 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 23 11 plasma membrane plasma membrane Eutheria Euteleostomi Cell.Organisms SLC26A11 HGNC:14471 solute carrier family 26 (anion exchanger), member 11 Q86WA9 Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12626430 plasma membrane 15 12 lysosome membrane. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms SLC26A2 HGNC:10994 solute carrier family 26 (anion exchanger), member 2 P50443 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11087667 plasma membrane 24 12 plasma membrane plasma membrane Chordata Bilateria Cell.Organisms SLC26A3 HGNC:3018 solute carrier family 26 (anion exchanger), member 3 P40879 Apical cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9473459 plasma membrane 24 12 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms SLC26A4 HGNC:8818 solute carrier family 26 (anion exchanger), member 4 O43511 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 11932316 plasma membrane 24 12 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms SLC26A5 HGNC:9359 solute carrier family 26 (anion exchanger), member 5 P58743 Cell membrane; Multi-pass membrane protein (By similarity). Note=Lateral wall of outer hair cells (By similarity). Plasma membrane (GO:0005886) 14747354 plasma membrane 94 12 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms SLC26A6 HGNC:14472 solute carrier family 26 (anion exchanger), member 6 Q9BXS9 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11247665,17081983 plasma membrane 30 12 nucleus. plasma membrane multiple NA NA Cell.Organisms SLC26A7 HGNC:14467 solute carrier family 26 (anion exchanger), member 7 Q8TE54 Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. Plasma membrane (GO:0005886) 15284286,12965893,12736153 plasma membrane 15 12 endosome. plasma membrane multiple Tetrapoda Tetrapoda Cell.Organisms SLC26A8 HGNC:14468 solute carrier family 26 (anion exchanger), member 8 Q96RN1 Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the sperm cell. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11278976,11278976 plasma membrane 14 12 cytoplasm. plasma membrane multiple Amniota Amniota Cell.Organisms SLC26A9 HGNC:14469 solute carrier family 26 (anion exchanger), member 9 Q7LBE3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737) 11834742,11834742 plasma membrane 22 13 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms SLC27A1 HGNC:10995 solute carrier family 27 (fatty acid transporter), member 1 Q6PCB7 Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm (By similarity). Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity). Plasma membrane (GO:0005886) 7954810 endoplasmic reticulum membrane 24 3 endomembrane system. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC27A2 HGNC:10996 solute carrier family 27 (fatty acid transporter), member 2 O14975 Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes. Peroxisome (GO:0005777); Microsome (GO:0005792); Endoplasmic reticulum (GO:0005783) 10198260,8939997,10479480,10198260,8939997,10479480,10198260,10479480 endoplasmic reticulum membrane 33 2 endoplasmic reticulum. endoplasmic reticulum membrane. peroxisome. peroxisome membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC27A3 HGNC:10997 solute carrier family 27 (fatty acid transporter), member 3 Q5K4L6 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 33 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria NA SLC27A4 HGNC:10998 solute carrier family 27 (fatty acid transporter), member 4 Q6P1M0 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 10518211 endoplasmic reticulum membrane 26 2 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC27A5 HGNC:10999 solute carrier family 27 (fatty acid transporter), member 5 Q9Y2P5 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 10479480,10749848 endoplasmic reticulum membrane 100 5 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euarchontoglires Mammalia Cell.Organisms SLC27A6 HGNC:11000 solute carrier family 27 (fatty acid transporter), member 6 Q9Y2P4 Membrane; Multi-pass membrane protein (Potential). Cell membrane, sarcolemma (By similarity). Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36 (By similarity). Plasma membrane (GO:0005886) 12556534 endoplasmic reticulum membrane 30 2 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC28A1 HGNC:11001 solute carrier family 28 (concentrative nucleoside transporter), member 1 O00337 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14668133,14581375,11396613 plasma membrane 100 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC28A2 HGNC:11002 solute carrier family 28 (concentrative nucleoside transporter), member 2 O43868 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12411296 plasma membrane 56 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC28A3 HGNC:16484 solute carrier family 28 (concentrative nucleoside transporter), member 3 Q9HAS3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 37 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC29A1 HGNC:11003 solute carrier family 29 (equilibrative nucleoside transporter), member 1 Q99808 Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. Plasma membrane (GO:0005886) 12389626 plasma membrane 100 11 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota SLC29A2 HGNC:11004 solute carrier family 29 (equilibrative nucleoside transporter), member 2 Q14542 Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells. Plasma membrane (GO:0005886); Nucleolus (GO:0005730) 14612157,12411296,12527552,7639753 plasma membrane 37 11 nucleus. nucleus membrane. plasma membrane multiple Mammalia Euteleostomi Eukaryota SLC29A3 HGNC:23096 solute carrier family 29 (equilibrative nucleoside transporter), member 3 Q9BZD2 Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface. Integral to membrane (GO:0016021) plasma membrane 20 11 plasma membrane plasma membrane Theria Bilateria Eukaryota SLC29A4 HGNC:23097 solute carrier family 29 (equilibrative nucleoside transporter), member 4 Q7RTT9 Cell membrane; Multi-pass membrane protein (Potential). Apical cell membrane; Multi-pass membrane protein (Potential). Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. Plasma membrane (GO:0005886) 15448143 plasma membrane 13 11 plasma membrane plasma membrane Mammalia Eukaryota Eukaryota SLC2A1 HGNC:11005 solute carrier family 2 (facilitated glucose transporter), member 1 P11166 Cell membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 11774318,11296192,12673735,10759149,7798206 plasma membrane 19 12 cytoplasm. golgi apparatus. melanosome. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms SLC2A10 HGNC:13444 solute carrier family 2 (facilitated glucose transporter), member 10 O95528 Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Plasma membrane (GO:0005886) 11247674 vacuole membrane 15 12 cytoplasm. endomembrane system. plasma membrane multiple Tetrapoda Eukaryota Cell.Organisms SLC2A11 HGNC:14239 solute carrier family 2 (facilitated glucose transporter), member 11 Q9BYW1 Cell membrane; Multi-pass membrane protein. Lysosome (GO:0005764); Plasma membrane (GO:0005886); Microsome (GO:0005792) 12175779,12175779,11583593,11583593 plasma membrane 100 12 lysosome. plasma membrane multiple Catarrhini Euteleostomi Cell.Organisms SLC2A12 HGNC:18067 solute carrier family 2 (facilitated glucose transporter), member 12 Q8TD20 Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region. Note=Localizes primarily perinuclear region in the absence of insulin. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11832379,11832379 plasma membrane 14 12 cytoplasm. plasma membrane multiple Amniota Euteleostomi Cell.Organisms SLC2A13 HGNC:15956 solute carrier family 2 (facilitated glucose transporter), member 13 Q96QE2 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11500374,11500374,11500374 plasma membrane 25 12 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms SLC2A14 HGNC:18301 solute carrier family 2 (facilitated glucose transporter), member 14 Q8TDB8 Membrane; Multi-pass membrane protein. plasma membrane 17 12 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms SLC2A2 HGNC:11006 solute carrier family 2 (facilitated glucose transporter), member 2 P11168 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11247674,16377570 plasma membrane 18 12 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLC2A3 HGNC:11007 solute carrier family 2 (facilitated glucose transporter), member 3 P11169 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9253355 plasma membrane 18 12 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms SLC2A4 HGNC:11009 solute carrier family 2 (facilitated glucose transporter), member 4 P14672 Cell membrane; Multi-pass membrane protein (By similarity). Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. Plasma membrane (GO:0005886) 11217863,11003568 plasma membrane 22 12 cytoplasm. endomembrane system. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms SLC2A4RG HGNC:15930 SLC2A4 regulator Q9NR83 Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10825161,14625278,14625278 nucleus 77 0 cytoplasm. nucleus multiple Catarrhini Eutheria Eumetazoa SLC2A5 HGNC:11010 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 P22732 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11247674 plasma membrane 28 12 plasma membrane plasma membrane Chordata Opisthokonta Cell.Organisms SLC2A6 HGNC:11011 solute carrier family 2 (facilitated glucose transporter), member 6 Q9UGQ3 Cell membrane; Multi-pass membrane protein (By similarity). Note=The dileucine internalization motif is critical for intracellular sequestration (By similarity). Plasma membrane (GO:0005886) 10970791 plasma membrane 17 12 plasma membrane plasma membrane Euteleostomi Bilateria NA SLC2A7 HGNC:13445 solute carrier family 2 (facilitated glucose transporter), member 7 Q6PXP3 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15033637 plasma membrane 28 12 plasma membrane plasma membrane Euarchontoglires Theria Cell.Organisms SLC2A8 HGNC:13812 solute carrier family 2 (facilitated glucose transporter), member 8 Q9NY64 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 10821868,10821868 plasma membrane 25 12 endoplasmic reticulum. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms SLC2A9 HGNC:13446 solute carrier family 2 (facilitated glucose transporter), member 9 Q9NRM0 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14739288,10970791 plasma membrane 27 12 plasma membrane plasma membrane Euarchontoglires Euteleostomi Cell.Organisms SLC30A1 HGNC:11012 solute carrier family 30 (zinc transporter), member 1 Q9Y6M5 Cell membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) mitochondrion membrane 28 6 plasma membrane plasma membrane Opisthokonta Eukaryota Cell.Organisms SLC30A10 HGNC:25355 solute carrier family 30, member 10 Q6XR72 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 20 6 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Cell.Organisms SLC30A2 HGNC:11013 solute carrier family 30 (zinc transporter), member 2 Q9BRI3 Vacuole membrane; Multi-pass membrane protein. Isoform 2: Lysosome membrane. Cytoplasmic vesicle (GO:0016023); Integral to membrane (GO:0016021) 8617223,8617223 vacuole membrane 74 4 vacuole membrane vacuole membrane Cell.Organisms Cell.Organisms Cell.Organisms SLC30A3 HGNC:11014 solute carrier family 30 (zinc transporter), member 3 Q99726 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (Probable). Cell junction, synapse, synaptosome (By similarity). Endosome (GO:0005768) 14657250 vacuole membrane 42 6 endosome endosome Cell.Organisms Cell.Organisms Cell.Organisms SLC30A4 HGNC:11015 solute carrier family 30 (zinc transporter), member 4 O14863 Endosome membrane; Multi-pass membrane protein (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11988082,10600821 vacuole membrane 31 6 cytoplasm. endosome membrane. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms SLC30A5 HGNC:19089 solute carrier family 30 (zinc transporter), member 5 Q8TAD4 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Secretory granule (GO:0030141);Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Secretory granule (GO:0030141) 11937503,11904301,11904301,11904301/11937503,11904301,11904301 golgi apparatus membrane 100 16 golgi apparatus. golgi apparatus membrane. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms SLC30A6 HGNC:19305 solute carrier family 30 (zinc transporter), member 6 Q6NXT4 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles (By similarity). Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Endosome (GO:0005768); Nucleus (GO:0005634) 11997387,11997387,11997387,17081983 golgi apparatus membrane 100 6 endosome. golgi apparatus. golgi apparatus membrane. nucleus multiple Deuterostomia Eukaryota Cell.Organisms SLC30A7 HGNC:19306 solute carrier family 30 (zinc transporter), member 7 Q8NEW0 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 12446736,12446736 golgi apparatus membrane 100 6 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Eukaryota Cell.Organisms SLC30A8 HGNC:20303 solute carrier family 30 (zinc transporter), member 8 Q8IWU4 Cell membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein (Probable). Note=Associated with insulin and glucagon secretory granules (By similarity). Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 15331542,15331542 vacuole membrane 39 6 plasma membrane plasma membrane Cell.Organisms Cell.Organisms Cell.Organisms SLC30A9 HGNC:1329 solute carrier family 30 (zinc transporter), member 9 Q6PML9 Membrane; Multi-pass membrane protein (Potential). Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10409434,11906820,10409434,11906820 nucleus 25 5 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms SLC31A1 HGNC:11016 solute carrier family 31 (copper transporter), member 1 O15431 Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11734551,12023893,12034741,12501239,12034741,12034741 plasma membrane 100 4 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Opisthokonta Eukaryota Eukaryota SLC31A2 HGNC:11017 solute carrier family 31 (copper transporter), member 2 O15432 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) vacuole membrane 25 3 vacuole membrane vacuole membrane Tetrapoda Euteleostomi Eukaryota SLC32A1 HGNC:11018 solute carrier family 32 (GABA vesicular transporter), member 1 Q9H598 Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) vacuole membrane 10 11 vacuole membrane vacuole membrane Bilateria Eukaryota Eukaryota SLC33A1 HGNC:95 solute carrier family 33 (acetyl-CoA transporter), member 1 O00400 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9096318,12739170,9096318,12739170 golgi apparatus membrane 25 12 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Opisthokonta Eukaryota Cell.Organisms SLC34A1 HGNC:11019 solute carrier family 34 (type II sodium/phosphate contransporter), member 1 Q06495 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8327470 golgi apparatus membrane 28 11 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms SLC34A2 HGNC:11020 solute carrier family 34 (type II sodium/phosphate contransporter), member 2 O95436 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10610722 golgi apparatus membrane 52 12 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms SLC34A3 HGNC:20305 solute carrier family 34 (type II sodium/phosphate contransporter), member 3 Q8N130 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11880379 golgi apparatus membrane 39 12 plasma membrane plasma membrane Theria Theria Cell.Organisms SLC35A1 HGNC:11021 solute carrier family 35 (CMP-sialic acid transporter), member A1 P78382 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 964426 golgi apparatus membrane 100 10 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Eukaryota Eukaryota SLC35A2 HGNC:11022 solute carrier family 35 (UDP-galactose transporter), member A2 P78381 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11389099,11279205,9399569,12925779,12925779 golgi apparatus membrane 100 10 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane multiple Opisthokonta Eukaryota NA SLC35A3 HGNC:11023 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 Q9Y2D2 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 10393322 golgi apparatus membrane 100 10 golgi apparatus. golgi apparatus membrane multiple Opisthokonta Eukaryota Eukaryota SLC35A4 HGNC:20753 solute carrier family 35, member A4 Q96G79 Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 12 9 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi Holozoa SLC35A5 HGNC:20792 solute carrier family 35, member A5 Q9BS91 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 14 10 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Eukaryota SLC35B1 HGNC:20798 solute carrier family 35, member B1 P78383 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 17 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota SLC35B2 HGNC:16872 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 Q8TB61 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 12716889 golgi apparatus membrane 100 9 golgi apparatus. golgi apparatus membrane multiple Euteleostomi Eukaryota Eukaryota SLC35B3 HGNC:21601 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 Q9H1N7 Golgi apparatus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 100 10 golgi apparatus membrane golgi apparatus membrane Bilateria Eukaryota Eukaryota SLC35B4 HGNC:20584 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 Q969S0 Golgi apparatus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 100 10 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota Eukaryota SLC35C1 HGNC:20197 solute carrier family 35 (GDP-fucose transporter), member C1 Q96A29 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 11326280 golgi apparatus membrane 100 10 golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Eukaryota SLC35C2 HGNC:17117 solute carrier family 35 (GDP-fucose transporter), member C2 Q9NQQ7 Membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634);Integral to membrane (GO:0016021) 17081983/ golgi apparatus membrane 6 10 nucleus nucleus Tetrapoda Eukaryota Eukaryota SLC35D1 HGNC:20800 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 Q9NTN3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11322953 endoplasmic reticulum membrane 100 10 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Eukaryota Eukaryota SLC35D2 HGNC:20799 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 Q76EJ3 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 15082721,15607426 golgi apparatus membrane 100 10 golgi apparatus. golgi apparatus membrane multiple Bilateria Eukaryota Eukaryota SLC35D3 HGNC:15621 solute carrier family 35, member D3 Q5M8T2 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 7 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota SLC35E1 HGNC:20803 solute carrier family 35, member E1 Q96K37 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 15 10 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Eukaryota SLC35E2 HGNC:20863 solute carrier family 35, member E2 P0CK97 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 11 4 golgi apparatus membrane golgi apparatus membrane NA NA Eukaryota SLC35E2B HGNC:33941 solute carrier family 35, member E2B P0CK96 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 12 10 mitochondrion membrane mitochondrion membrane Amniota Eukaryota Eukaryota SLC35E3 HGNC:20864 solute carrier family 35, member E3 Q7Z769 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 15 10 golgi apparatus membrane golgi apparatus membrane Deuterostomia Eukaryota Eukaryota SLC35E4 HGNC:17058 solute carrier family 35, member E4 Q6ICL7 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 7 9 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Eukaryota SLC35F1 HGNC:21483 solute carrier family 35, member F1 Q5T1Q4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 24 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota SLC35F2 HGNC:23615 solute carrier family 35, member F2 Q8IXU6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 21 10 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota SLC35F3 HGNC:23616 solute carrier family 35, member F3 Q8IY50 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 6 10 vacuole membrane vacuole membrane Euteleostomi Bilateria Holozoa SLC35F4 HGNC:19845 solute carrier family 35, member F4 A4IF30 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 3 10 vacuole membrane vacuole membrane Bilateria Bilateria Cell.Organisms SLC35F5 HGNC:23617 solute carrier family 35, member F5 Q8WV83 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 23 10 vacuole membrane vacuole membrane Opisthokonta Eukaryota Eukaryota SLC35F6 HGNC:26055 solute carrier family 35, member F6 Q8N357 Mitochondrion. Lysosome membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 13 9 lysosome membrane. mitochondrion multiple Eukaryota Eukaryota Eukaryota SLC35G1 HGNC:26607 solute carrier family 35, member G1 Q2M3R5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 43 10 golgi apparatus membrane golgi apparatus membrane Deuterostomia Cell.Organisms Cell.Organisms SLC35G2 HGNC:28480 solute carrier family 35, member G2 Q8TBE7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,17081983 golgi apparatus membrane 60 10 golgi apparatus membrane golgi apparatus membrane Chordata Chordata Cell.Organisms SLC35G3 HGNC:26848 solute carrier family 35, member G3 Q8N808 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 38 9 golgi apparatus membrane golgi apparatus membrane Euarchontoglires Eutheria Euteleostomi SLC35G5 HGNC:15546 solute carrier family 35, member G5 Q96KT7 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 49 9 golgi apparatus membrane golgi apparatus membrane Human Human Euteleostomi SLC35G6 HGNC:31351 solute carrier family 35, member G6 P0C7Q6 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 43 9 golgi apparatus membrane golgi apparatus membrane NA NA Euteleostomi SLC36A1 HGNC:18761 solute carrier family 36 (protomino acid symporter), member 1 Q7Z2H8 Cell membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein. Lysosome (GO:0005764); Plasma membrane (GO:0005886) 12598615,12527723,12598615 vacuole membrane 17 11 lysosome. lysosome membrane. plasma membrane multiple Eukaryota Eukaryota Eukaryota SLC36A2 HGNC:18762 solute carrier family 36 (protomino acid symporter), member 2 Q495M3 Cell membrane; Multi-pass membrane protein. Cytoplasm (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Endosome (GO:0005768) 11959859,14600155,14600155 vacuole membrane 13 11 endoplasmic reticulum. endosome. plasma membrane multiple Eukaryota Eukaryota Eukaryota SLC36A3 HGNC:19659 solute carrier family 36, member 3 Q495N2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 13 11 vacuole membrane vacuole membrane Eukaryota Eukaryota Eukaryota SLC36A4 HGNC:19660 solute carrier family 36 (protomino acid symporter), member 4 Q6YBV0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 12 11 vacuole membrane vacuole membrane Eukaryota Eukaryota Eukaryota SLC37A1 HGNC:11024 solute carrier family 37 (glucose-6-phosphate transporter), member 1 P57057 Membrane; Multi-pass membrane protein (Potential). plasma membrane 23 12 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms SLC37A2 HGNC:20644 solute carrier family 37 (glucose-6-phosphate transporter), member 2 Q8TED4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 10 12 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Cell.Organisms SLC37A3 HGNC:20651 solute carrier family 37, member 3 Q8NCC5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 10 12 mitochondrion membrane mitochondrion membrane Deuterostomia Cell.Organisms Cell.Organisms SLC37A4 HGNC:4061 solute carrier family 37 (glucose-6-phosphate transporter), member 4 O43826 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10318794,10318794,10318794 mitochondrion membrane 5 12 cytoplasm. endoplasmic reticulum. plasma membrane multiple Deuterostomia Cell.Organisms NA SLC38A1 HGNC:13447 solute carrier family 38, member 1 Q9H2H9 Cell membrane; Multi-pass membrane protein. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity). Plasma membrane (GO:0005886) 15054072 plasma membrane 100 11 plasma membrane plasma membrane Deuterostomia Eukaryota Eukaryota SLC38A10 HGNC:28237 solute carrier family 38, member 10 Q9HBR0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum 18 11 endoplasmic reticulum endoplasmic reticulum Mammalia Bilateria Eukaryota SLC38A11 HGNC:26836 solute carrier family 38, member 11 Q08AI6 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 12 10 vacuole membrane vacuole membrane Euteleostomi Opisthokonta Eukaryota SLC38A2 HGNC:13448 solute carrier family 38, member 2 Q96QD8 Cell membrane; Multi-pass membrane protein. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12054432,17081983,17081983 plasma membrane 100 11 cytoplasm. nucleus. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota SLC38A3 HGNC:18044 solute carrier family 38, member 3 Q99624 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 11085536 plasma membrane 88 11 plasma membrane plasma membrane Deuterostomia Eukaryota NA SLC38A4 HGNC:14679 solute carrier family 38, member 4 Q969I6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11414754 plasma membrane 100 11 plasma membrane plasma membrane Theria Euteleostomi Eukaryota SLC38A5 HGNC:18070 solute carrier family 38, member 5 Q8WUX1 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 85 11 plasma membrane plasma membrane Human Theria Eukaryota SLC38A6 HGNC:19863 solute carrier family 38, member 6 Q8IZM9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 38 11 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota SLC38A7 HGNC:25582 solute carrier family 38, member 7 Q9NVC3 Membrane; Multi-pass membrane protein (By similarity). Note=In neurons, located in soma and axons (By similarity). plasma membrane 7 11 plasma membrane plasma membrane Deuterostomia Eukaryota Eukaryota SLC38A8 HGNC:32434 solute carrier family 38, member 8 A6NNN8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 7 11 plasma membrane plasma membrane Mammalia Opisthokonta Eukaryota SLC38A9 HGNC:26907 solute carrier family 38, member 9 Q8NBW4 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 15 11 vacuole membrane vacuole membrane Deuterostomia Bilateria Eukaryota SLC39A1 HGNC:12876 solute carrier family 39 (zinc transporter), member 1 Q9NY26 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11696349,11696349,11696349 plasma membrane 33 8 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. plasma membrane multiple Theria Eukaryota Eukaryota SLC39A10 HGNC:20861 solute carrier family 39 (zinc transporter), member 10 Q9ULF5 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12659941 plasma membrane 35 6 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms SLC39A11 HGNC:14463 solute carrier family 39, member 11 Q8N1S5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 20 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Cell.Organisms Cell.Organisms Cell.Organisms SLC39A12 HGNC:20860 solute carrier family 39 (zinc transporter), member 12 Q504Y0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 32 6 plasma membrane plasma membrane Bilateria Bilateria NA SLC39A13 HGNC:20859 solute carrier family 39 (zinc transporter), member 13 Q96H72 Golgi apparatus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 100 6 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Cell.Organisms SLC39A14 HGNC:20858 solute carrier family 39 (zinc transporter), member 14 Q15043 Cell membrane; Multi-pass membrane protein (Potential). Cell projection, lamellipodium. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae. Plasma membrane (GO:0005886) 12659941 plasma membrane 84 6 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms SLC39A2 HGNC:17127 solute carrier family 39 (zinc transporter), member 2 Q9NP94 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10681536 plasma membrane 100 8 plasma membrane plasma membrane Mammalia Eukaryota Holozoa SLC39A3 HGNC:17128 solute carrier family 39 (zinc transporter), member 3 Q9BRY0 Membrane; Multi-pass membrane protein (Potential). Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 17081983/15054103,15054103 plasma membrane 20 8 cytoplasm. plasma membrane multiple Mammalia Eukaryota Eukaryota SLC39A4 HGNC:17129 solute carrier family 39 (zinc transporter), member 4 Q6P5W5 Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. Plasma membrane (GO:0005886) 12068297 plasma membrane 37 6 endosome. plasma membrane multiple Euteleostomi Euteleostomi NA SLC39A5 HGNC:20502 solute carrier family 39 (zinc transporter), member 5 Q6ZMH5 Basolateral cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 15322118 plasma membrane 81 6 plasma membrane plasma membrane Eutheria Mammalia Cell.Organisms SLC39A6 HGNC:18607 solute carrier family 39 (zinc transporter), member 6 Q13433 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12659941 plasma membrane 100 6 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLC39A7 HGNC:4927 solute carrier family 39 (zinc transporter), member 7 Q92504 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 14525538,14525538 plasma membrane 28 7 endoplasmic reticulum. plasma membrane multiple Theria Eukaryota NA SLC39A8 HGNC:20862 solute carrier family 39 (zinc transporter), member 8 Q9C0K1 Membrane; Multi-pass membrane protein (Potential). Note=Associated with the lysosomal/endosomal compartment following transfection. Lysosome (GO:0005764); Endosome (GO:0005768) 12504855,12504855 plasma membrane 38 6 endosome. lysosome multiple Tetrapoda Euteleostomi Cell.Organisms SLC39A9 HGNC:20182 solute carrier family 39, member 9 Q9NUM3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 20 8 plasma membrane plasma membrane Bilateria Opisthokonta Cell.Organisms SLC3A1 HGNC:11025 solute carrier family 3 (amino acid transporter heavy chain), member 1 Q07837 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11318953,10574970,15598749 mitochondrion 18 1 mitochondrion. plasma membrane multiple Opisthokonta Cell.Organisms Cell.Organisms SLC3A2 HGNC:11026 solute carrier family 3 (amino acid transporter heavy chain), member 2 P08195 Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Extracellular (GO:0005576) 17081983,17081983/7204970,12270127,11435306,10574970,15598749,15561729 cytoplasm 6 1 cytoplasm. melanosome. mitochondrion. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms SLC40A1 HGNC:10909 solute carrier family 40 (iron-regulated transporter), member 1 Q9NP59 Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11925460,12161425 plasma membrane 100 12 cytoplasm. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms SLC41A1 HGNC:19429 solute carrier family 41 (magnesium transporter), member 1 Q8IVJ1 Cell membrane; Multi-pass membrane protein. plasma membrane 100 10 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC41A2 HGNC:31045 solute carrier family 41 (magnesium transporter), member 2 Q96JW4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 11 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC41A3 HGNC:31046 solute carrier family 41, member 3 Q96GZ6 Cell membrane; Multi-pass membrane protein. plasma membrane 100 14 plasma membrane plasma membrane Theria Euteleostomi Cell.Organisms SLC43A1 HGNC:9225 solute carrier family 43 (amino acid system L transporter), member 1 O75387 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 12930836 vacuole membrane 10 12 plasma membrane plasma membrane Deuterostomia Deuterostomia Eukaryota SLC43A2 HGNC:23087 solute carrier family 43 (amino acid system L transporter), member 2 Q8N370 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) vacuole membrane 7 12 vacuole membrane vacuole membrane Deuterostomia Deuterostomia Eukaryota SLC43A3 HGNC:17466 solute carrier family 43, member 3 Q8NBI5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 17 12 vacuole membrane vacuole membrane Chordata Eukaryota Eukaryota SLC44A1 HGNC:18798 solute carrier family 44 (choline transporter), member 1 Q8WWI5 Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 32 10 mitochondrion membrane. plasma membrane multiple Deuterostomia Bilateria Eukaryota SLC44A2 HGNC:17292 solute carrier family 44 (choline transporter), member 2 Q8IWA5 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 28 10 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota SLC44A3 HGNC:28689 solute carrier family 44, member 3 Q8N4M1 Membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 7 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Amniota Eukaryota SLC44A4 HGNC:13941 solute carrier family 44, member 4 Q53GD3 Membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) plasma membrane 27 10 plasma membrane plasma membrane Bilateria Eukaryota NA SLC44A5 HGNC:28524 solute carrier family 44, member 5 Q8NCS7 Membrane; Multi-pass membrane protein (By similarity). plasma membrane 32 10 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota SLC45A1 HGNC:17939 solute carrier family 45, member 1 Q9Y2W3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 14 12 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms SLC45A2 HGNC:16472 solute carrier family 45, member 2 Q9UMX9 Melanosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11574907 plasma membrane 14 12 melanosome membrane. plasma membrane multiple Euteleostomi Eukaryota Cell.Organisms SLC45A3 HGNC:8642 solute carrier family 45, member 3 Q96JT2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 9 12 plasma membrane plasma membrane Euteleostomi Deuterostomia Eukaryota SLC45A4 HGNC:29196 solute carrier family 45, member 4 Q5BKX6 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 15 12 vacuole membrane vacuole membrane Euteleostomi Euteleostomi Cell.Organisms SLC46A1 HGNC:30521 solute carrier family 46 (folate transporter), member 1 Q96NT5 Apical cell membrane; Multi-pass membrane protein. Cytoplasm (By similarity). Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells (By similarity). Apical membrane (GO:0016327); Plasma membrane (GO:0005886); Intracellular vesicle (None) 17475902,17446347,16143108,17129779,17446347 vacuole membrane 6 12 plasma membrane plasma membrane Bilateria Bilateria NA SLC46A2 HGNC:16055 solute carrier family 46, member 2 Q9BY10 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10706709 plasma membrane 34 11 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa SLC46A3 HGNC:27501 solute carrier family 46, member 3 Q7Z3Q1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 23 12 plasma membrane plasma membrane Amniota Euteleostomi Holozoa SLC47A1 HGNC:25588 solute carrier family 47 (multidrug and toxin extrusion), member 1 Q96FL8 Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles. Apical membrane (GO:0016327) 16330770 plasma membrane 100 13 plasma membrane plasma membrane Eukaryota Cell.Organisms Cell.Organisms SLC47A2 HGNC:26439 solute carrier family 47 (multidrug and toxin extrusion), member 2 Q86VL8 Cell membrane; Multi-pass membrane protein (Potential). Note=Localized at the brush border membranes of the proximal tubules. Brush border (GO:0005903); Nucleus (GO:0005634) 16807400,17081983 plasma membrane 41 15 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms SLC48A1 HGNC:26035 solute carrier family 48 (heme transporter), member 1 Q6P1K1 Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 42 4 endosome membrane. lysosome membrane multiple NA NA Bilateria SLC4A1 HGNC:11027 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) P02730 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 1639060,12898519,15811326,8960772,8960772,8960772 plasma membrane 78 11 golgi apparatus. mitochondrion. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms SLC4A10 HGNC:13811 solute carrier family 4, sodium bicarbonate transporter, member 10 Q6U841 Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane (By similarity). Plasma membrane (GO:0005886) 14592810 plasma membrane 100 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC4A11 HGNC:16438 solute carrier family 4, sodium borate transporter, member 11 Q8NBS3 Cell membrane. Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 11 13 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SLC4A1AP HGNC:13813 solute carrier family 4 (anion exchanger), member 1, adaptor protein Q9BWU0 Nucleus. Cytoplasm. Note=Mainly nuclear. Small amounts are found in the cytoplasm. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12800979,11772400,12800979 cytoplasm 27 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms SLC4A2 HGNC:11028 solute carrier family 4 (anion exchanger), member 2 P04920 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12225956,11156694,17081983,17081983 plasma membrane 52 13 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Bilateria Eukaryota Cell.Organisms SLC4A3 HGNC:11029 solute carrier family 4 (anion exchanger), member 3 P48751 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11248201 plasma membrane 48 13 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC4A4 HGNC:11030 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 Q9Y6R1 Basolateral cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9651366 plasma membrane 100 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC4A5 HGNC:18168 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 Q9BY07 Apical cell membrane; Multi-pass membrane protein. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. Plasma membrane (GO:0005886) 11087115 plasma membrane 100 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC4A7 HGNC:11033 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Q9Y6M7 Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein (By similarity). Cell projection, stereocilium (By similarity). Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). Plasma membrane (GO:0005886) 9610397 plasma membrane 73 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC4A8 HGNC:11034 solute carrier family 4, sodium bicarbonate cotransporter, member 8 Q2Y0W8 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10362779 plasma membrane 72 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC4A9 HGNC:11035 solute carrier family 4, sodium bicarbonate cotransporter, member 9 Q96Q91 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 84 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC50A1 HGNC:30657 solute carrier family 50 (sugar efflux transporter), member 1 Q9BRV3 Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=May also localize to the endoplasmic reticulum (By similarity). Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytosol (GO:0005829) ,14991772,14991772,14991772 plasma membrane 14 7 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. plasma membrane multiple Theria Eukaryota Eukaryota SLC51A HGNC:29955 solute carrier family 51, alpha subunit Q86UW1 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. endoplasmic reticulum membrane 41 7 plasma membrane plasma membrane NA NA Bilateria SLC51B HGNC:29956 solute carrier family 51, beta subunit Q86UW2 Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. plasma membrane 100 1 plasma membrane plasma membrane NA NA Amniota SLC52A1 HGNC:30225 solute carrier family 52 (riboflavin transporter), member 1 Q9NWF4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12740431,12740431 plasma membrane 100 10 endoplasmic reticulum. plasma membrane multiple Theria Euteleostomi Metazoa SLC52A2 HGNC:30224 solute carrier family 52 (riboflavin transporter), member 2 Q9HAB3 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 10 plasma membrane plasma membrane Theria Euteleostomi NA SLC52A3 HGNC:16187 solute carrier family 52 (riboflavin transporter), member 3 Q9NQ40 Cell membrane; Multi-pass membrane protein. plasma membrane 100 10 plasma membrane plasma membrane Bilateria Bilateria Holozoa SLC5A1 HGNC:11036 solute carrier family 5 (sodium/glucose cotransporter), member 1 P13866 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7759499,12543931,12488461 plasma membrane 45 14 plasma membrane. secreted multiple Deuterostomia Cell.Organisms Cell.Organisms SLC5A10 HGNC:23155 solute carrier family 5 (sodium/sugar cotransporter), member 10 A0PJK1 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC5A11 HGNC:23091 solute carrier family 5 (sodium/inositol cotransporter), member 11 Q8WWX8 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 45 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC5A12 HGNC:28750 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 Q1EHB4 Apical cell membrane; Multi-pass membrane protein. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity). Integral to membrane (GO:0016021) plasma membrane 100 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC5A2 HGNC:11037 solute carrier family 5 (sodium/glucose cotransporter), member 2 P31639 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8244402 plasma membrane 49 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC5A3 HGNC:11038 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 P53794 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9685419 plasma membrane 95 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC5A4 HGNC:11039 solute carrier family 5 (glucose activated ion channel), member 4 Q9NY91 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 13130073 plasma membrane 38 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC5A5 HGNC:11040 solute carrier family 5 (sodium/iodide cotransporter), member 5 Q92911 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12588808 plasma membrane 40 13 plasma membrane plasma membrane Euarchontoglires Cell.Organisms Cell.Organisms SLC5A6 HGNC:11041 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 Q9Y289 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10329687 plasma membrane 35 13 plasma membrane plasma membrane Mammalia Cell.Organisms Cell.Organisms SLC5A7 HGNC:14025 solute carrier family 5 (sodium/choline cotransporter), member 7 Q9GZV3 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasmic vesicle (GO:0016023) 11027560,15090548,12969261,12969261,12969261 plasma membrane 10 13 endosome. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC5A8 HGNC:19119 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 Q8N695 Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12107270,15001644,15001644 plasma membrane 100 13 cytoplasm. plasma membrane multiple NA NA NA SLC5A9 HGNC:22146 solute carrier family 5 (sodium/sugar cotransporter), member 9 Q2M3M2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 56 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC6A1 HGNC:11042 solute carrier family 6 (neurotransmitter transporter), member 1 P30531 Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). Plasma membrane (GO:0005886) 9623887 plasma membrane 42 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC6A11 HGNC:11044 solute carrier family 6 (neurotransmitter transporter), member 11 P48066 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 62 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC6A12 HGNC:11045 solute carrier family 6 (neurotransmitter transporter), member 12 P48065 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7589472 plasma membrane 66 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC6A13 HGNC:11046 solute carrier family 6 (neurotransmitter transporter), member 13 Q9NSD5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC6A14 HGNC:11047 solute carrier family 6 (amino acid transporter), member 14 Q9UN76 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12388375 plasma membrane 31 12 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms SLC6A15 HGNC:13621 solute carrier family 6 (neutral amino acid transporter), member 15 Q9H2J7 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 11112352 plasma membrane 32 12 plasma membrane plasma membrane Chordata Bilateria Cell.Organisms SLC6A16 HGNC:13622 solute carrier family 6, member 16 Q9GZN6 Membrane; Multi-pass membrane protein. Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 11112352,11112352 plasma membrane 18 12 plasma membrane plasma membrane Eutheria Eutheria Cell.Organisms SLC6A17 HGNC:31399 solute carrier family 6 (neutral amino acid transporter), member 17 Q9H1V8 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 32 12 plasma membrane plasma membrane Chordata Bilateria Cell.Organisms SLC6A18 HGNC:26441 solute carrier family 6 (neutral amino acid transporter), member 18 Q96N87 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) plasma membrane 35 12 plasma membrane plasma membrane Chordata Chordata Cell.Organisms SLC6A19 HGNC:27960 solute carrier family 6 (neutral amino acid transporter), member 19 Q695T7 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 15286787 plasma membrane 33 12 plasma membrane plasma membrane Chordata Chordata Cell.Organisms SLC6A2 HGNC:11048 solute carrier family 6 (neurotransmitter transporter), member 2 P23975 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9808705 plasma membrane 33 12 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC6A20 HGNC:30927 solute carrier family 6 (proline IMINO transporter), member 20 Q9NP91 Apical cell membrane; Multi-pass membrane protein (By similarity). Note=Located in the apical brush border membrane of kidney proximal tubule cells (By similarity). Plasma membrane (GO:0005886) 9932288 plasma membrane 90 12 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms SLC6A3 HGNC:11049 solute carrier family 6 (neurotransmitter transporter), member 3 Q01959 Membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737) 12746456,12746456,17380124,12746456,10823899 plasma membrane 32 12 cytoplasm. endoplasmic reticulum. endosome. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC6A4 HGNC:11050 solute carrier family 6 (neurotransmitter transporter), member 4 P31645 Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11071889,11311448,11298795,10579573,10364189,10579573,11311448,11311448,10579573 plasma membrane 32 12 cytoplasm. endomembrane system. endoplasmic reticulum. endosome membrane. golgi apparatus. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC6A5 HGNC:11051 solute carrier family 6 (neurotransmitter transporter), member 5 Q9Y345 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasmic vesicle (GO:0016023); Synaptic vesicle (GO:0008021) 14675166,12738009,12091465,11709067,12091465,15276154 plasma membrane 35 12 endosome. plasma membrane multiple Deuterostomia Bilateria Cell.Organisms SLC6A6 HGNC:11052 solute carrier family 6 (neurotransmitter transporter), member 6 P31641 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1518851 plasma membrane 100 12 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC6A7 HGNC:11054 solute carrier family 6 (neurotransmitter transporter), member 7 Q99884 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7651355 plasma membrane 38 12 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms SLC6A8 HGNC:11055 solute carrier family 6 (neurotransmitter transporter), member 8 P48029 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7945388 plasma membrane 45 12 plasma membrane plasma membrane Bilateria Eukaryota NA SLC6A9 HGNC:11056 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 P48067 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8183239 plasma membrane 32 12 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms SLC7A1 HGNC:11057 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 P30825 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12388095 plasma membrane 52 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC7A10 HGNC:11058 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 Q9NS82 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 15458438 plasma membrane 31 12 plasma membrane plasma membrane Euteleostomi Opisthokonta Cell.Organisms SLC7A11 HGNC:11059 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 Q9UPY5 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11417227,11302733 plasma membrane 32 12 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms SLC7A13 HGNC:23092 solute carrier family 7 (anionic amino acid transporter), member 13 Q8TCU3 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11907033 plasma membrane 20 12 plasma membrane plasma membrane Amniota Amniota Cell.Organisms SLC7A14 HGNC:29326 solute carrier family 7, member 14 Q8TBB6 Membrane; Multi-pass membrane protein (Potential). plasma membrane 40 14 plasma membrane plasma membrane Euteleostomi Cell.Organisms Cell.Organisms SLC7A2 HGNC:11060 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 P52569 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8954799 plasma membrane 49 14 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC7A3 HGNC:11061 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 Q8WY07 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11591158,10446328 plasma membrane 100 14 nucleus. plasma membrane multiple Deuterostomia Cell.Organisms Cell.Organisms SLC7A4 HGNC:11062 solute carrier family 7, member 4 O43246 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) plasma membrane 30 14 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC7A5 HGNC:11063 solute carrier family 7 (amino acid transporter light chain, L system), member 5 Q01650 Cytoplasm, cytosol. Apical cell membrane; Multi-pass membrane protein. Note=Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 7829099,1597461,11095508,15598749 plasma membrane 38 12 cytoplasm. mitochondrion. plasma membrane multiple Chordata Bilateria Cell.Organisms SLC7A6 HGNC:11064 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 Q92536 Basolateral cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10391915,9829974 plasma membrane 100 12 plasma membrane plasma membrane Chordata Opisthokonta Cell.Organisms SLC7A6OS HGNC:25807 solute carrier family 7, member 6 opposite strand Q96CW6 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 17081983 nucleus 97 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa SLC7A7 HGNC:11065 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 Q9UM01 Basolateral cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9829974 plasma membrane 100 12 plasma membrane plasma membrane Chordata Opisthokonta Cell.Organisms SLC7A8 HGNC:11066 solute carrier family 7 (amino acid transporter light chain, L system), member 8 Q9UHI5 Cytoplasm. Basolateral cell membrane; Multi- pass membrane protein. Note=Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. Plasma membrane (GO:0005886) 10391915,11311135,10574970 plasma membrane 36 12 cytoplasm. plasma membrane multiple Euteleostomi Opisthokonta Cell.Organisms SLC7A9 HGNC:11067 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 P82251 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 11157794 plasma membrane 30 12 plasma membrane plasma membrane Deuterostomia Cell.Organisms Cell.Organisms SLC8A1 HGNC:11068 solute carrier family 8 (sodium/calcium exchanger), member 1 P32418 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8921376 plasma membrane 100 10 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC8A2 HGNC:11069 solute carrier family 8 (sodium/calcium exchanger), member 2 Q9UPR5 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8021246 plasma membrane 62 10 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC8A3 HGNC:11070 solute carrier family 8 (sodium/calcium exchanger), member 3 P57103 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 14722618,12406570 plasma membrane 67 11 plasma membrane plasma membrane Bilateria Eukaryota Cell.Organisms SLC8B1 HGNC:26175 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Q6J4K2 Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Note=Mainly localizes to mitochondrion inner membrane. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 14625281,14625281,14625281 vacuole membrane 18 13 cytoplasm. endoplasmic reticulum. mitochondrion membrane. plasma membrane multiple Opisthokonta Eukaryota Eukaryota SLC9A1 HGNC:11071 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 P19634 Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. Plasma membrane (GO:0005886) 11163215,1979310,16710297 plasma membrane 60 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC9A2 HGNC:11072 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 Q9UBY0 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11254504 plasma membrane 41 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC9A3 HGNC:11073 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 P48764 Cell membrane; Multi-pass membrane protein. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Plasma membrane (GO:0005886); Endosome (GO:0005768) 12397398,11841999,12763917 plasma membrane 100 13 endosome. plasma membrane multiple Amniota Euteleostomi Cell.Organisms SLC9A3R1 HGNC:11075 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 O14745 Cytoplasm (By similarity). Apical cell membrane (By similarity). Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T- cells. Cytoplasm (GO:0005737); Membrane fraction (GO:0005624) 11684085,16456542 nucleus 29 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms SLC9A3R2 HGNC:11076 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 Q15599 Endomembrane system; Peripheral membrane protein. Nucleus. Apical cell membrane (By similarity). Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Apical membrane (GO:0016327) 9748260,16166090,9748260,16166090,16203867 cytoplasm 23 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms SLC9A4 HGNC:11077 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 Q6AI14 Apical cell membrane; Multi-pass membrane protein (By similarity). Basolateral cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic granule membrane; Multi-pass membrane protein (By similarity). Note=Found in zymogen granule membranes (By similarity). Integral to membrane (GO:0016021) plasma membrane 32 13 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms SLC9A5 HGNC:11078 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 Q14940 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12598940,9933641 plasma membrane 47 13 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms SLC9A6 HGNC:11079 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 Q92581 Endosome membrane; Multi-pass membrane protein. Note=Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 9507001,11940519 golgi apparatus membrane 27 13 endosome membrane. mitochondrion. plasma membrane multiple Opisthokonta Cell.Organisms NA SLC9A7 HGNC:17123 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 Q96T83 Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794) 11279194 golgi apparatus membrane 24 13 endosome. golgi apparatus. golgi apparatus membrane multiple Opisthokonta Cell.Organisms NA SLC9A8 HGNC:20728 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 Q9Y2E8 Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 15522866,12409279 golgi apparatus membrane 100 12 golgi apparatus. golgi apparatus membrane. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms SLC9A9 HGNC:20653 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 Q8IVB4 Late endosome membrane; Multi-pass membrane protein. Endosome (GO:0005768) 15522866 golgi apparatus membrane 24 13 endosome. endosome membrane multiple Opisthokonta Cell.Organisms Cell.Organisms SLC9B1 HGNC:24244 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 Q4ZJI4 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 47 14 mitochondrion membrane mitochondrion membrane Euarchontoglires Eutheria Cell.Organisms SLC9B2 HGNC:25143 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Q86UD5 Mitochondrion membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 77 14 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Cell.Organisms SLC9C1 HGNC:31401 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 Q4G0N8 Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity). plasma membrane 6 17 plasma membrane plasma membrane Mammalia Mammalia Cell.Organisms SLC9C2 HGNC:28664 solute carrier family 9, member C2 (putative) Q5TAH2 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 4 17 plasma membrane plasma membrane Theria Cell.Organisms Cell.Organisms SLCO1A2 HGNC:10956 solute carrier organic anion transporter family, member 1A2 P46721 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886);Integral to membrane (GO:0016021) 9328325,9398014,10779507/9398014 plasma membrane 100 12 plasma membrane plasma membrane Amniota Amniota Holozoa SLCO1B1 HGNC:10959 solute carrier organic anion transporter family, member 1B1 Q9Y6L6 Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10706707,10644574,10706707 plasma membrane 100 12 plasma membrane. secreted multiple Deuterostomia Deuterostomia Holozoa SLCO1B3 HGNC:10961 solute carrier organic anion transporter family, member 1B3 Q9NPD5 Basolateral cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10779507,12695556,11677211,11375950 plasma membrane 100 12 plasma membrane plasma membrane Deuterostomia Deuterostomia Holozoa SLCO1B7 HGNC:32934 solute carrier organic anion transporter family, member 1B7 (non-functional) G3V0H7 Cell membrane; Multi-pass membrane protein (Potential). plasma membrane 72 11 plasma membrane plasma membrane NA NA Holozoa SLCO1C1 HGNC:13819 solute carrier organic anion transporter family, member 1C1 Q9NYB5 Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). Plasma membrane (GO:0005886) 12923172,12830001,12702494,12130705 plasma membrane 100 12 plasma membrane plasma membrane Deuterostomia Deuterostomia Holozoa SLCO2A1 HGNC:10955 solute carrier organic anion transporter family, member 2A1 Q92959 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8787677 plasma membrane 100 12 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa SLCO2B1 HGNC:10962 solute carrier organic anion transporter family, member 2B1 O94956 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10873595 plasma membrane 100 12 plasma membrane plasma membrane Theria Euteleostomi Holozoa SLCO3A1 HGNC:10952 solute carrier organic anion transporter family, member 3A1 Q9UIG8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 12 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa SLCO4A1 HGNC:10953 solute carrier organic anion transporter family, member 4A1 Q96BD0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 12 plasma membrane plasma membrane Bilateria Bilateria Holozoa SLCO4C1 HGNC:23612 solute carrier organic anion transporter family, member 4C1 Q6ZQN7 Basolateral cell membrane; Multi-pass membrane protein (By similarity). Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney (By similarity). Plasma membrane (GO:0005886) 14993604 plasma membrane 77 12 plasma membrane plasma membrane Bilateria Bilateria Eukaryota SLCO5A1 HGNC:19046 solute carrier organic anion transporter family, member 5A1 Q9H2Y9 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 12 plasma membrane plasma membrane Chordata Bilateria Holozoa SLCO6A1 HGNC:23613 solute carrier organic anion transporter family, member 6A1 Q86UG4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 12 plasma membrane plasma membrane Eutheria Eutheria Holozoa SLFN11 HGNC:26633 schlafen family member 11 Q7Z7L1 Nucleus. nucleus 100 0 nucleus nucleus Theria Theria Deuterostomia SLFN12 HGNC:25500 schlafen family member 12 Q8IYM2 nucleus 28 0 nucleus nucleus Euarchontoglires Eutheria Craniata SLFN12L HGNC:33920 schlafen family member 12-like Q6IEE8 Membrane; Single-pass membrane protein. nucleus 28 1 nucleus nucleus Euarchontoglires Eutheria Craniata SLFN13 HGNC:26481 schlafen family member 13 Q68D06 nucleus 72 0 nucleus nucleus Theria Theria Deuterostomia SLFN14 HGNC:32689 schlafen family member 14 P0C7P3 nucleus 33 0 nucleus nucleus NA NA Cell.Organisms SLFN5 HGNC:28286 schlafen family member 5 Q08AF3 nucleus 42 0 nucleus nucleus Theria Theria Deuterostomia SLFNL1 HGNC:26313 schlafen-like 1 Q499Z3 nucleus 56 0 nucleus nucleus Mammalia Mammalia Cell.Organisms SLIRP HGNC:20495 SRA stem-loop interacting RNA binding protein Q9GZT3 Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters. Nucleus (GO:0005634) mitochondrion 23 0 mitochondrion. nucleus multiple Amniota Eukaryota Cell.Organisms SLIT1 HGNC:11085 slit homolog 1 (Drosophila) O75093 Secreted (By similarity). Extracellular (GO:0005576) secreted 58 0 secreted secreted Bilateria Bilateria Cell.Organisms SLIT2 HGNC:11086 slit homolog 2 (Drosophila) O94813 Secreted. Note=The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10102268,11375980,10102268 secreted 100 0 secreted secreted Bilateria Bilateria Cell.Organisms SLIT3 HGNC:11087 slit homolog 3 (Drosophila) O75094 Secreted (By similarity). Extracellular (GO:0005576); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 11443047,11443047,11443047 secreted 58 0 mitochondrion. secreted multiple Bilateria Bilateria Cell.Organisms SLITRK1 HGNC:20297 SLIT and NTRK-like family, member 1 Q96PX8 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 14550773 secreted 13 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms SLITRK2 HGNC:13449 SLIT and NTRK-like family, member 2 Q9H156 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 13 1 plasma membrane plasma membrane Euteleostomi Euteleostomi NA SLITRK3 HGNC:23501 SLIT and NTRK-like family, member 3 O94933 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 14550773 plasma membrane 17 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLITRK4 HGNC:23502 SLIT and NTRK-like family, member 4 Q8IW52 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 14557068 secreted 14 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLITRK5 HGNC:20295 SLIT and NTRK-like family, member 5 O94991 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 14550773 plasma membrane 12 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLITRK6 HGNC:23503 SLIT and NTRK-like family, member 6 Q9H5Y7 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 14 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SLK HGNC:11088 STE20-like kinase Q9H2G2 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 10611247 cytoplasm 81 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms SLMAP HGNC:16643 sarcolemma associated protein Q14BN4 Cell membrane, sarcolemma; Single-pass type IV membrane protein (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity). Plasma membrane (GO:0005886); Sarcoplasmic reticulum (GO:0016529); Cytoplasm (GO:0005737) 9405447,9405447,17081983 cytoplasm 26 1 cytoplasm. endoplasmic reticulum. plasma membrane multiple Bilateria Opisthokonta Opisthokonta SLMO1 HGNC:24639 slowmo homolog 1 (Drosophila) Q96N28 mitochondrion 38 0 mitochondrion mitochondrion Tetrapoda Euteleostomi Eukaryota SLMO2 HGNC:15892 slowmo homolog 2 (Drosophila) Q9Y3B1 mitochondrion 45 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota SLN HGNC:11089 sarcolipin O00631 Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 9575189 secreted 40 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euarchontoglires Euarchontoglires Eutheria SLPI HGNC:11092 secretory leukocyte peptidase inhibitor P03973 Secreted. Extracellular (GO:0005576) 12874244 secreted 100 0 secreted secreted Euarchontoglires Mammalia Eumetazoa SLTM HGNC:20709 SAFB-like, transcription modulator Q9NWH9 Nucleus (By similarity). Note=Detected in punctate structures (By similarity). Nucleus (GO:0005634) 15561729 nucleus 89 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms SLU7 HGNC:16939 SLU7 splicing factor homolog (S. cerevisiae) O95391 Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the HC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. Nucleus (GO:0005634) 10197984,15181151 nucleus 14 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SLURP1 HGNC:18746 secreted LY6/PLAUR domain containing 1 P55000 Secreted. secreted 100 0 secreted secreted Theria Theria Chordata SLX1A HGNC:20922 SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) Q9BQ83 Nucleus. Nucleus (GO:0005634) ,19596236, nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms SLX1B HGNC:28748 SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) Q9BQ83 Nucleus. nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms SLX4 HGNC:23845 SLX4 structure-specific endonuclease subunit Q8IY92 Nucleus. Note=Localizes to sites of DNA dammage. Nucleus (GO:0005634) ,19596236, nucleus 100 0 nucleus nucleus Chordata Bilateria Opisthokonta SLX4IP HGNC:16225 SLX4 interacting protein Q5VYV7 nucleus 83 0 nucleus nucleus Amniota Euteleostomi Euteleostomi SMAD1 HGNC:6767 SMAD family member 1 Q15797 Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cell projection (GO:0042995) 8653785,9006934,14732718,17183365,8653785,11451566,17183365,10749680 nucleus 19 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa SMAD2 HGNC:6768 SMAD family member 2 Q15796 Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634) 10825365,8752209,11043574,15280432,12191473,16751101,,9389648,11359933,8752209,11043574,15280432,12191473,16751101,18511908,/17081983 nucleus 19 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa SMAD3 HGNC:6769 SMAD family member 3 P84022 Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10846168,16751101,18832382,10846168,16751101 nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa SMAD4 HGNC:6770 SMAD family member 4 Q13485 Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD. PDPK1 prevents its nuclear translocation in response to TGF- beta. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11265759,15452148,18832382,11741830 nucleus 30 0 cytoplasm. nucleus multiple Chordata Bilateria Metazoa SMAD5 HGNC:6771 SMAD family member 5 Q99717 Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Perinuclear region (GO:0048471); Mitochondrion (GO:0005739) 12060751,17081983,12060751,12849988,12849988 nucleus 17 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Metazoa SMAD6 HGNC:6772 SMAD family member 6 O43541 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11483516,11483516 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Metazoa SMAD7 HGNC:6773 SMAD family member 7 O15105 Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12519765,9786930,16601693,15684397,12519765,9786930,16601693,15684397,12151385,9786930 nucleus 44 0 cytoplasm. nucleus multiple Chordata Chordata Metazoa SMAD9 HGNC:6774 SMAD family member 9 O15198 Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9205116,9205116 nucleus 21 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa SMAGP HGNC:26918 small cell adhesion glycoprotein Q0VAQ4 Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions. Detected on cytoplasmic membranes in undifferentiated tumors. Integral to membrane (GO:0016021) plasma membrane 21 1 plasma membrane plasma membrane Eutheria Tetrapoda Euteleostomi SMAP1 HGNC:19651 small ArfGAP 1 Q8IYB5 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Integral to membrane (GO:0016021) 12119110 cytoplasm 41 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota SMAP2 HGNC:25082 small ArfGAP2 Q8WU79 Cytoplasm. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota SMARCA1 HGNC:11097 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 P28370 Nucleus. Nucleus (GO:0005634) 1408766,17081983 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms SMARCA2 HGNC:11098 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 P51531 Nucleus. Nucleus (GO:0005634); Extracellular (GO:0005576);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,8223438,12566296,12493776,15696166,17081983,16940996,,14718574/17081983,17081983 nucleus 100 0 cytoplasm. nucleus. secreted multiple Opisthokonta Eukaryota Cell.Organisms SMARCA4 HGNC:11100 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 P51532 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) ,12044884,17081983,11013263,16565076,,15635413,11780067 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms SMARCA5 HGNC:11101 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 O60264 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10655480,12972596,19059367,15635413,16514417 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms SMARCAD1 HGNC:18398 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 Q9H4L7 Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double- strand breaks (DSBs) sites of DNA damage. Nucleus (GO:0005634) 11031099,17081983 nucleus 100 1 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms SMARCAL1 HGNC:11102 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 Q9NZC9 Nucleus (By similarity). Nucleus (GO:0005634) 10857751 nucleus 27 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms SMARCB1 HGNC:11103 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Q12824 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776) ,15696166,11013263,,11780067 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota SMARCC1 HGNC:11104 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Q92922 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776); Cytoplasm (GO:0005737) ,9693044,15696166,17081983,11013263,,11780067,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota SMARCC2 HGNC:11105 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Q8TAQ2 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776);Nucleus (GO:0005634) ,9435219,19059367,11013263,,11780067/17081983 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota SMARCD1 HGNC:11106 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Q96GM5 Nucleus (Probable). Nucleus (GO:0005634); Kinetochore (GO:0000776) 9892636,11780067 nucleus 71 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SMARCD2 HGNC:11107 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Q92925 Nucleus. Nucleus (GO:0005634) 8804307 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SMARCD3 HGNC:11108 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Q6STE5 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14701856/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SMARCE1 HGNC:11109 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Q969G3 Nucleus. Nucleus (GO:0005634); Kinetochore (GO:0000776) 9435219,15696166,19059367,11780067 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota SMC1A HGNC:11111 structural maintenance of chromosomes 1A Q14683 Nucleus. Chromosome. Chromosome, centromere, kinetochore. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Cytoplasm (GO:0005737); Kinetochore (GO:0000776) 11877377,16438930,15635413,11790298,17113138,17113138,15561729 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA SMC1B HGNC:11112 structural maintenance of chromosomes 1B Q8NDV3 Nucleus. Chromosome (By similarity). Chromosome, centromere (By similarity). Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). Nucleus (GO:0005634); Mitochondrion (GO:0005739) 12759374,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Eukaryota Cell.Organisms SMC2 HGNC:14011 structural maintenance of chromosomes 2 O95347 Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9789013,15561729,15635413,15598749 nucleus 31 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SMC3 HGNC:2468 structural maintenance of chromosomes 3 Q9UQE7 Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser- 1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Mitochondrion (GO:0005739); Kinetochore (GO:0000776) 9506951,11790298,15635413,17113138,15598749,15561729 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SMC4 HGNC:14013 structural maintenance of chromosomes 4 Q9NTJ3 Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 9789013,11850403,17081983,15635413,15598749,17081983 nucleus 27 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SMC5 HGNC:20465 structural maintenance of chromosomes 5 Q8IY18 Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SMC6 HGNC:20466 structural maintenance of chromosomes 6 Q96SB8 Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms SMCHD1 HGNC:29090 structural maintenance of chromosomes flexible hinge domain containing 1 A6NHR9 Chromosome (By similarity). Note=Localizes to Barr body (By similarity). nucleus 84 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms SMCO1 HGNC:27407 single-pass membrane protein with coiled-coil domains 1 Q147U7 Membrane; Single-pass membrane protein (Potential). nucleus 57 0 nucleus nucleus Eutheria Eutheria Craniata SMCO2 HGNC:34448 single-pass membrane protein with coiled-coil domains 2 A6NFE2 Membrane; Single-pass membrane protein (Potential). nucleus 45 1 nucleus nucleus Eutheria Eutheria Eutheria SMCO3 HGNC:34401 single-pass membrane protein with coiled-coil domains 3 A2RU48 Membrane; Single-pass membrane protein (Potential). mitochondrion 24 2 mitochondrion mitochondrion Theria Amniota Amniota SMCO4 HGNC:24810 single-pass membrane protein with coiled-coil domains 4 Q9NRQ5 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 31 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi NA SMCP HGNC:6962 sperm mitochondria-associated cysteine-rich protein P49901 Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 8916043,8916043 cytoplasm 14 0 cytoplasm. mitochondrion multiple Catarrhini Catarrhini Primates SMCR8 HGNC:17921 Smith-Magenis syndrome chromosome region, candidate 8 Q8TEV9 nucleus 75 0 nucleus nucleus Amniota Euteleostomi Eukaryota SMCR9 HGNC:17913 Smith-Magenis syndrome chromosome region, candidate 9 P0DM48 cytoplasm 71 0 cytoplasm cytoplasm NA NA NA SMDT1 HGNC:25055 single-pass membrane protein with aspartate-rich tail 1 Q9H4I9 Mitochondrion (Potential). Membrane; Single- pass membrane protein (Potential). Mitochondrion (GO:0005739) 16582907 mitochondrion membrane 19 1 mitochondrion mitochondrion Tetrapoda Bilateria NA SMEK1 HGNC:20219 SMEK homolog 1, suppressor of mek1 (Dictyostelium) Q6IN85 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16107728,16107728 nucleus 17 2 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota SMEK2 HGNC:29267 SMEK homolog 2, suppressor of mek1 (Dictyostelium) Q5MIZ7 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions. nucleus 20 2 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota SMG1 HGNC:30045 SMG1 phosphatidylinositol 3-kinase-related kinase Q96Q15 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15175154,17081983,15175154 cytoplasm 22 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SMG5 HGNC:24644 SMG5 nonsense mediated mRNA decay factor Q9UPR3 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14636577,14636577 cytoplasm 18 2 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota SMG6 HGNC:17809 SMG6 nonsense mediated mRNA decay factor Q86US8 Nucleus, nucleolus. Chromosome, telomere (Probable). Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 12676087,12676087 nucleus 24 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SMG7 HGNC:16792 SMG7 nonsense mediated mRNA decay factor Q92540 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. cytoplasm 16 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota SMG8 HGNC:25551 SMG8 nonsense mediated mRNA decay factor Q8ND04 nucleus 21 1 nucleus nucleus Bilateria Bilateria Eukaryota SMG9 HGNC:25763 SMG9 nonsense mediated mRNA decay factor Q9H0W8 Cytoplasm (GO:0005737) 17081983 nucleus 59 1 cytoplasm cytoplasm Theria Eukaryota Eukaryota SMIM1 HGNC:44204 small integral membrane protein 1 (Vel blood group) B2RUZ4 Membrane; Single-pass membrane protein (Potential). secreted 40 1 secreted secreted NA NA Craniata SMIM10 HGNC:41913 small integral membrane protein 10 Q96HG1 Cell membrane; Single-pass type I membrane protein (Potential). mitochondrion 15 2 mitochondrion mitochondrion Catarrhini Catarrhini Amniota SMIM11 HGNC:1293 small integral membrane protein 11 P58511 Membrane; Single-pass membrane protein (Potential). nucleus 18 1 nucleus nucleus Human Human Euteleostomi SMIM12 HGNC:25154 small integral membrane protein 12 Q96EX1 Membrane; Single-pass membrane protein (Potential). cytoplasm 14 1 cytoplasm cytoplasm Catarrhini Catarrhini Eumetazoa SMIM13 HGNC:27356 small integral membrane protein 13 P0DJ93 Membrane; Single-pass membrane protein (Potential). plasma membrane 46 1 plasma membrane plasma membrane NA NA Bilateria SMIM14 HGNC:27321 small integral membrane protein 14 Q96QK8 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 65 1 secreted secreted Bilateria Bilateria Eumetazoa SMIM15 HGNC:33861 small integral membrane protein 15 Q7Z3B0 Membrane; Single-pass membrane protein (Potential). nucleus 22 1 nucleus nucleus Deuterostomia Deuterostomia Bilateria SMIM17 HGNC:27114 small integral membrane protein 17 P0DL12 Membrane; Single-pass membrane protein (Potential). secreted 48 1 secreted secreted NA NA NA SMIM18 HGNC:42973 small integral membrane protein 18 P0DKX4 Membrane; Single-pass membrane protein (Potential). secreted 38 1 secreted secreted NA NA Olfactores SMIM19 HGNC:25166 small integral membrane protein 19 Q96E16 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 12 1 secreted secreted Euteleostomi Euteleostomi Deuterostomia SMIM2 HGNC:28776 small integral membrane protein 2 Q9BVW6 Membrane; Single-pass membrane protein (Potential). nucleus 16 1 nucleus nucleus Catarrhini Catarrhini Primates SMIM20 HGNC:37260 small integral membrane protein 20 Q8N5G0 Membrane; Single-pass membrane protein (Potential). nucleus 11 1 nucleus nucleus NA NA Holozoa SMIM21 HGNC:27598 small integral membrane protein 21 Q3B7S5 Membrane; Single-pass membrane protein (Potential). secreted 43 1 secreted secreted Homininae Homininae Eutheria SMIM22 HGNC:48329 small integral membrane protein 22 K7EJ46 secreted 89 1 secreted secreted NA NA NA SMIM23 HGNC:34440 small integral membrane protein 23 A6NLE4 Cell membrane; Single-pass type II membrane protein (Potential). secreted 29 1 secreted secreted Eutheria Eutheria Eutheria SMIM24 HGNC:37244 small integral membrane protein 24 O75264 Membrane; Single-pass membrane protein (Potential). secreted 37 1 secreted secreted Human Eutheria Euteleostomi SMIM3 HGNC:30248 small integral membrane protein 3 Q9BZL3 Membrane; Single-pass membrane protein (Potential). mitochondrion membrane 20 1 mitochondrion membrane mitochondrion membrane NA NA Amniota SMIM4 HGNC:37257 small integral membrane protein 4 Q8WVI0 Membrane; Single-pass membrane protein (Potential). mitochondrion 46 1 mitochondrion mitochondrion Theria Bilateria Metazoa SMIM5 HGNC:40030 small integral membrane protein 5 Q71RC9 Membrane; Single-pass membrane protein (Potential). secreted 78 1 secreted secreted NA NA Amniota SMIM6 HGNC:40032 small integral membrane protein 6 P0DI80 Membrane; Single-pass membrane protein (Potential). secreted 22 1 secreted secreted NA NA Euarchontoglires SMIM7 HGNC:28419 small integral membrane protein 7 Q9BQ49 Membrane; Single-pass type I membrane protein (Potential). mitochondrion 3 1 mitochondrion mitochondrion NA NA Holozoa SMIM8 HGNC:21401 small integral membrane protein 8 Q96KF7 Membrane; Single-pass membrane protein (Potential). mitochondrion membrane 10 1 mitochondrion membrane mitochondrion membrane Euteleostomi Bilateria Holozoa SMIM9 HGNC:41915 small integral membrane protein 9 A6NGZ8 Cell membrane; Single-pass type I membrane protein (Potential). plasma membrane 14 1 plasma membrane plasma membrane Homininae Euarchontoglires NA SMKR1 HGNC:43561 small lysine-rich protein 1 H3BMG3 nucleus 88 0 nucleus nucleus NA NA Bilateria SMLR1 HGNC:44670 small leucine-rich protein 1 H3BR10 Membrane; Multi-pass membrane protein (Potential). secreted 22 2 n/a n/a NA NA Euarchontoglires SMN1 HGNC:11117 survival of motor neuron 1, telomeric Q16637 Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10767334,11704667,12065586,15848170,17081983,11704667,9600994,9302277,10767334,15222879,12065586,9600994,15848170,17081983 nucleus 29 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa SMN2 HGNC:11118 survival of motor neuron 2, centromeric Q16637 Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9323129,8670859,9323129 nucleus 29 0 cytoplasm. nucleus multiple Bilateria Bilateria NA SMNDC1 HGNC:16900 survival motor neuron domain containing 1 O75940 Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9817934,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SMO HGNC:11119 smoothened, frizzled class receptor Q99835 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endosome (GO:0005768) 11748145,12123571 plasma membrane 15 7 endosome. plasma membrane multiple Deuterostomia Bilateria Eukaryota SMOC1 HGNC:20318 SPARC related modular calcium binding 1 Q9H4F8 Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane. Extracellular (GO:0005576) 12130637 secreted 23 0 secreted secreted Bilateria Bilateria Eumetazoa SMOC2 HGNC:20323 SPARC related modular calcium binding 2 Q9H3U7 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Extracellular (GO:0005576) 12031507 secreted 26 0 secreted secreted Human Euteleostomi Cell.Organisms SMOX HGNC:15862 spermine oxidase Q9NWM0 Isoform 1: Cytoplasm. Nucleus. Isoform 4: Cytoplasm. Nucleus. Isoform 6: Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Peroxisome (GO:0005777) 14764092,12798,3181599,14764092,12798 mitochondrion 39 0 cytoplasm. nucleus. peroxisome multiple Bilateria Eukaryota Cell.Organisms SMPD1 HGNC:11120 sphingomyelin phosphodiesterase 1, acid lysosomal P17405 Lysosome. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Lysosome (GO:0005764) 11001565,15849201,15849201,11001565 secreted 22 0 endoplasmic reticulum. lysosome. secreted multiple Mammalia Eukaryota Cell.Organisms SMPD2 HGNC:11121 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) O60906 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9520418 secreted 50 2 plasma membrane plasma membrane Opisthokonta Eukaryota Cell.Organisms SMPD3 HGNC:14240 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) Q9NY59 Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells. Golgi apparatus (GO:0005794) 10823942 plasma membrane 48 2 golgi apparatus golgi apparatus Deuterostomia Deuterostomia Cell.Organisms SMPD4 HGNC:32949 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) Q9NXE4 Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Secretory vesicle (None) 16517606,16517606,16517606,15598749,16517606,16517606 endoplasmic reticulum membrane 65 3 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. mitochondrion. plasma membrane multiple Deuterostomia Bilateria Opisthokonta SMPDL3A HGNC:17389 sphingomyelin phosphodiesterase, acid-like 3A Q92484 Secreted (By similarity). Zymogen granule (GO:0042588) 16278343 vacuole membrane 15 0 vacuole membrane vacuole membrane Opisthokonta Eukaryota Cell.Organisms SMPDL3B HGNC:21416 sphingomyelin phosphodiesterase, acid-like 3B Q92485 Secreted (By similarity). secreted 16 1 secreted secreted Opisthokonta Eukaryota Cell.Organisms SMPX HGNC:11122 small muscle protein, X-linked Q9UHP9 Nucleus (GO:0005634) 11401441 nucleus 16 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi SMR3A HGNC:19216 submaxillary gland androgen regulated protein 3A Q99954 Secreted (Potential). secreted 100 0 secreted secreted Human Human Primates SMR3B HGNC:17326 submaxillary gland androgen regulated protein 3B P02814 Secreted. Extracellular (GO:0005576) 479131 secreted 100 0 secreted secreted Human Human Primates SMS HGNC:11123 spermine synthase P52788 cytoplasm 25 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms SMTN HGNC:11126 smoothelin P53814 Cytoplasm, cytoskeleton. Note=Exhibits a filamentous organization. Cytoplasm (GO:0005737) 10550614,9113392,8707825 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SMTNL1 HGNC:32394 smoothelin-like 1 A8MU46 Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, I band (By similarity). Cytoplasm, myofibril, sarcomere, M line (By similarity). Nucleus (By similarity). Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). cytoplasm 36 0 cytoplasm cytoplasm Theria Theria Eukaryota SMTNL2 HGNC:24764 smoothelin-like 2 Q2TAL5 cytoplasm 59 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota SMU1 HGNC:18247 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) Q2TAY7 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11410362,11410362 nucleus 11 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms SMUG1 HGNC:17148 single-strand-selective monofunctional uracil-DNA glycosylase 1 Q53HV7 Nucleus. Nucleolus (GO:0005730) 12161446 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms SMURF1 HGNC:16807 SMAD specific E3 ubiquitin protein ligase 1 Q9HCE7 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12519765,12519765 cytoplasm 38 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota SMURF2 HGNC:16809 SMAD specific E3 ubiquitin protein ligase 2 Q9HAU4 Nucleus. Cytoplasm. Cell membrane. Membrane raft. Note=Cytoplasmic in the presence of SMAD7. Co-localizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cell projection (GO:0042995) 11163210,11163210,17318188 cytoplasm 37 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota NA SMYD1 HGNC:20986 SET and MYND domain containing 1 Q8NB12 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) endoplasmic reticulum membrane 33 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Eukaryota SMYD2 HGNC:20982 SET and MYND domain containing 2 Q9NRG4 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) endoplasmic reticulum membrane 34 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota SMYD3 HGNC:15513 SET and MYND domain containing 3 Q9H7B4 Cytoplasm. Nucleus. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15235609,15235609 endoplasmic reticulum membrane 41 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms SMYD4 HGNC:21067 SET and MYND domain containing 4 Q8IYR2 nucleus 23 1 nucleus nucleus Deuterostomia Eukaryota Eukaryota SMYD5 HGNC:16258 SMYD family member 5 Q6GMV2 cytoplasm 42 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota SNAI1 HGNC:11128 snail family zinc finger 1 O95863 Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,12832491,19004823,,,12832491,19004823, nucleus 42 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eukaryota SNAI2 HGNC:11094 snail family zinc finger 2 O43623 Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions. Nucleus (GO:0005634) 10866665 nucleus 49 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SNAI3 HGNC:18411 snail family zinc finger 3 Q3KNW1 Nucleus (By similarity). nucleus 68 0 nucleus nucleus Mammalia Mammalia Eukaryota SNAP23 HGNC:11131 synaptosomal-associated protein, 23kDa O00161 Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794); Secretory granule (GO:0030141); Late endosome (GO:0005770);Plasma membrane (GO:0005886);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11001914,9168999,9815132,16272324,11842301,10588641,11001914,16272324,11842301,9815132,11842301,11842301,10036234/11444845/11444845,17081983 cytoplasm 32 0 cytoplasm. endosome. golgi apparatus multiple Euteleostomi Euteleostomi Cell.Organisms SNAP25 HGNC:11132 synaptosomal-associated protein, 25kDa P60880 Cytoplasm, perinuclear region (By similarity). Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10954418,9452464,10644766,10085240,12114505,17363971,10954418,10644766,10954418,10085240 cytoplasm 10 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms SNAP29 HGNC:11133 synaptosomal-associated protein, 29kDa O95721 Cytoplasm. Membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023); Zymogen granule (GO:0042588) 9852078,9852078,9852078,9852078,11423532,16278343 nucleus 36 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota SNAP47 HGNC:30669 synaptosomal-associated protein, 47kDa Q5SQN1 Endomembrane system (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Appears to be exclusively membrane-bound (By similarity). nucleus 47 0 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa SNAP91 HGNC:14986 synaptosomal-associated protein, 91kDa O60641 Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12847086,12847086 cytoplasm 16 0 cytoplasm cytoplasm Human Opisthokonta Eukaryota SNAPC1 HGNC:11134 small nuclear RNA activating complex, polypeptide 1, 43kDa Q16533 Nucleus. Nucleus (GO:0005634) 8524284 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota SNAPC2 HGNC:11135 small nuclear RNA activating complex, polypeptide 2, 45kDa Q13487 Nucleus. Nucleus (GO:0005634) 9418884 nucleus 100 0 nucleus nucleus Theria Euteleostomi Craniata SNAPC3 HGNC:11136 small nuclear RNA activating complex, polypeptide 3, 50kDa Q92966 Nucleus. Nucleus (GO:0005634) 11094070 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SNAPC4 HGNC:11137 small nuclear RNA activating complex, polypeptide 4, 190kDa Q5SXM2 Nucleus (Potential). Nucleus (GO:0005634) 9418884 nucleus 22 1 nucleus nucleus Bilateria Eukaryota Eukaryota SNAPC5 HGNC:15484 small nuclear RNA activating complex, polypeptide 5, 19kDa O75971 Nucleus. Nucleus (GO:0005634) 9732265 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi SNAPIN HGNC:17145 SNAP-associated protein O95295 Cytoplasm (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell junction, synapse, synaptosome. Cytoplasm, perinuclear region. Golgi apparatus membrane (By similarity). Note=May be cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N-terminal signal anchor (By similarity). Co-localizes with NANOS1 and PUM2 in the perinuclear region of germ cells. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 10195194,12877659 nucleus 74 0 cytoplasm. golgi apparatus multiple Theria Eukaryota Eukaryota SNCA HGNC:11138 synuclein, alpha (non A4 component of amyloid precursor) P37840 Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11279280,11279280,16269331 cytoplasm 59 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Craniata SNCAIP HGNC:11139 synuclein, alpha interacting protein Q9Y6H5 Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA. Cytoplasm (GO:0005737) 10319874 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms SNCB HGNC:11140 synuclein, beta Q16143 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11588588,11588588 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata SNCG HGNC:11141 synuclein, gamma (breast cancer-specific protein 1) O76070 Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Nucleus (GO:0005634) 9801372,11746666,11746666,16678164 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata SND1 HGNC:30646 staphylococcal nuclease and tudor domain containing 1 Q7KZF4 Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Nucleus (GO:0005634) 11691653,7651391,15652821,17081983 cytoplasm 80 0 cytoplasm. melanosome. nucleus multiple Eukaryota Eukaryota Cell.Organisms SNED1 HGNC:24696 sushi, nidogen and EGF-like domains 1 Q8TER0 Secreted (Potential). secreted 24 0 secreted secreted Mammalia Euteleostomi Cell.Organisms SNF8 HGNC:17028 SNF8, ESCRT-II complex subunit Q96H20 Cytoplasm. Endosome membrane. Nucleus (Probable). Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation. cytoplasm 47 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SNIP1 HGNC:30587 Smad nuclear interacting protein 1 Q8TAD8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10887155,17157259,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SNN HGNC:11149 stannin O75324 Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 9413842,9413842 mitochondrion membrane 100 1 cytoplasm. mitochondrion. mitochondrion membrane multiple Tetrapoda Euteleostomi Craniata SNPH HGNC:15931 syntaphilin O15079 Membrane; Single-pass membrane protein (Potential). Cell junction, synapse, synaptosome. Plasma membrane (GO:0005886) 10707983 cytoplasm 11 1 plasma membrane plasma membrane Theria Euteleostomi Craniata SNRK HGNC:30598 SNF related kinase Q9NRH2 Nucleus (By similarity). Nucleus (GO:0005634) 10930554 nucleus 88 0 nucleus nucleus Chordata Eukaryota Cell.Organisms SNRNP200 HGNC:30859 small nuclear ribonucleoprotein 200kDa (U5) O75643 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9539711,15635413,11790298,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SNRNP25 HGNC:14161 small nuclear ribonucleoprotein 25kDa (U11/U12) Q9BV90 Nucleus. Nucleus (GO:0005634) 15146077 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SNRNP27 HGNC:30240 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) Q8WVK2 Nucleus (Potential). nucleus 31 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SNRNP35 HGNC:30852 small nuclear ribonucleoprotein 35kDa (U11/U12) Q16560 Nucleus. Nucleolus (GO:0005730) 15146077 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota SNRNP40 HGNC:30857 small nuclear ribonucleoprotein 40kDa (U5) Q96DI7 Nucleus. Nucleus (GO:0005634) 9774689 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SNRNP48 HGNC:21368 small nuclear ribonucleoprotein 48kDa (U11/U12) Q6IEG0 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota SNRNP70 HGNC:11150 small nuclear ribonucleoprotein 70kDa (U1) P08621 Nucleus. Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity). Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7516470,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SNRPA HGNC:11151 small nuclear ribonucleoprotein polypeptide A P09012 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10648562,9848648,15635413 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SNRPA1 HGNC:11152 small nuclear ribonucleoprotein polypeptide A' P09661 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 2928112,11790298,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SNRPB HGNC:11153 small nuclear ribonucleoprotein polypeptides B and B1 P14678 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Ribosome (GO:0005840) 11343899,2522439,15105431,15561729 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SNRPB2 HGNC:11155 small nuclear ribonucleoprotein polypeptide B P08579 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9576861,2139037,7593271,2139037 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SNRPC HGNC:11157 small nuclear ribonucleoprotein polypeptide C P09234 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 2961811,15652821,15635413 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota SNRPD1 HGNC:11158 small nuclear ribonucleoprotein D1 polypeptide 16kDa P62314 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10747894,10747849 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SNRPD2 HGNC:11159 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa P62316 Nucleus. Nucleus (GO:0005634) 7527560 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SNRPD3 HGNC:11160 small nuclear ribonucleoprotein D3 polypeptide 18kDa P62318 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 7527560,11790298 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota SNRPE HGNC:11161 small nuclear ribonucleoprotein polypeptide E P62304 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10025403,2522439,1688550 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SNRPF HGNC:11162 small nuclear ribonucleoprotein polypeptide F P62306 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10025403,2522439,1688550 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SNRPG HGNC:11163 small nuclear ribonucleoprotein polypeptide G P62308 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9417867,9417867 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SNRPN HGNC:11164 small nuclear ribonucleoprotein polypeptide N P63162 Nucleus. Nucleus (GO:0005634) 10318933 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SNTA1 HGNC:11167 syntrophin, alpha 1 Q13424 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11168526,14722086,17081983 cytoplasm 21 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Holozoa SNTB1 HGNC:11168 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) Q13884 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions (By similarity). Cytoplasm (GO:0005737) 11168526 cytoplasm 22 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa SNTB2 HGNC:11169 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) Q13425 Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction (By similarity). Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737); Microtubule (GO:0005874); Nucleus (GO:0005634) 17081983,17081983/11168526,17081983,10404183,17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Bilateria Bilateria NA SNTG1 HGNC:13740 syntrophin, gamma 1 Q9NSN8 Cytoplasm, cytoskeleton. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10747910,11352924,11352924 nucleus 26 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa SNTG2 HGNC:13741 syntrophin, gamma 2 Q9NY99 Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane. Cytoplasm (GO:0005737) 10747910 cytoplasm 22 0 cytoplasm cytoplasm Amniota Euteleostomi Holozoa SNTN HGNC:33706 sentan, cilia apical structure protein A6NMZ2 Cell projection, cilium (By similarity). Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A-subfibers (By similarity). cytoplasm 22 1 cytoplasm cytoplasm Theria Amniota Craniata SNUPN HGNC:14245 snurportin 1 O95149 Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta. It is re- exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9670026,12095920,9670026,12095920 nucleus 58 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SNURF HGNC:11171 SNRPN upstream reading frame Q9Y675 Nucleus. Nucleus (GO:0005634) 10318933 nucleus 100 0 nucleus nucleus Human Human Boreoeutheria SNW1 HGNC:16696 SNW domain containing 1 Q13573 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9569025,15878163,17081983,15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SNX1 HGNC:11172 sorting nexin 1 Q13596 Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endosome (GO:0005768);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737);Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9819414,9819414,11309204/9819414,9819414/11997453,12198132,11309204,12657642,9819414,9819414 cytoplasm 35 0 cytoplasm. endosome multiple Euteleostomi Opisthokonta Eukaryota SNX10 HGNC:14974 sorting nexin 10 Q9Y5X0 Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum. Cytoplasm (GO:0005737) 11485546 secreted 9 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota SNX11 HGNC:14975 sorting nexin 11 Q9Y5W9 Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Endosome. secreted 14 0 endosome endosome Euteleostomi Euteleostomi Eukaryota SNX12 HGNC:14976 sorting nexin 12 Q9UMY4 Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm (GO:0005737); Endosome (GO:0005768) 11485546,11485546 secreted 20 0 cytoplasm. endosome multiple Opisthokonta Eukaryota Eukaryota SNX13 HGNC:21335 sorting nexin 13 Q9Y5W8 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome (GO:0005768) 11729322 cytoplasm 13 3 endosome endosome Bilateria Bilateria Eukaryota SNX14 HGNC:14977 sorting nexin 14 Q9Y5W7 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 11500980 cytoplasm 8 2 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Eukaryota SNX15 HGNC:14978 sorting nexin 15 Q9NRS6 Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471); Early endosome (GO:0005769) 11085978,11085978,11208079,11208079,11208079 cytoplasm 15 0 cytoplasm. endosome multiple Theria Euteleostomi Metazoa SNX16 HGNC:14980 sorting nexin 16 P57768 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Lysosome (By similarity). Early endosome (GO:0005769); Late endosome (GO:0005770); Lysosome (GO:0005764); Perinuclear region (GO:0048471) 12813048,12813048,12813048,12813048 cytoplasm 20 0 cytoplasm. endosome. lysosome multiple Euteleostomi Bilateria Eukaryota SNX17 HGNC:14979 sorting nexin 17 Q15036 Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Endosome (GO:0005768) 11237770,11237770,12169628 nucleus 31 0 cytoplasm. endosome multiple Bilateria Eukaryota Eukaryota SNX18 HGNC:19245 sorting nexin 18 Q96RF0 Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Golgi apparatus (GO:0005794) cytoplasm 26 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SNX19 HGNC:21532 sorting nexin 19 Q92543 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Integral to membrane (GO:0016021) nucleus 15 3 nucleus nucleus Chordata Chordata Opisthokonta SNX2 HGNC:11173 sorting nexin 2 O60749 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome (GO:0005768); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11485546,17351151,9819414,9819414 cytoplasm 8 0 cytoplasm. endosome multiple Eukaryota Eukaryota Eukaryota SNX20 HGNC:30390 sorting nexin 20 Q7Z614 Cell membrane. Cytoplasm. Nucleus. Endosome. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737) nucleus 55 0 cytoplasm. endosome. nucleus multiple Amniota Euteleostomi Eukaryota SNX21 HGNC:16154 sorting nexin family member 21 Q969T3 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). nucleus 58 0 nucleus nucleus Euteleostomi Bilateria Opisthokonta SNX22 HGNC:16315 sorting nexin 22 Q96L94 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). nucleus 33 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SNX24 HGNC:21533 sorting nexin 24 Q9Y343 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). secreted 9 0 secreted secreted Euteleostomi Eukaryota Opisthokonta SNX25 HGNC:21883 sorting nexin 25 Q9H3E2 Endosome membrane; Peripheral membrane protein. Note=Detected in endosome-derived secreted vesicles (exosomes) from malignant pleural effusions. Nucleus (GO:0005634) 17081983 cytoplasm 9 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta SNX27 HGNC:20073 sorting nexin family member 27 Q96L92 Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products. Cytosol (GO:0005829); Endosome (GO:0005768); Microsome (GO:0005792) 17351151,17351151,17351151 nucleus 37 0 cytoplasm. endosome multiple Bilateria Bilateria Eukaryota SNX29 HGNC:30542 sorting nexin 29 Q8TEQ0 Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 nucleus 14 0 nucleus nucleus Deuterostomia Bilateria Eukaryota SNX3 HGNC:11174 sorting nexin 3 O60493 Early endosome. Endosome (GO:0005768); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 11433298,11433298,9819414,11433298 secreted 23 0 cytoplasm. endosome multiple Opisthokonta Eukaryota Eukaryota SNX30 HGNC:23685 sorting nexin family member 30 Q5VWJ9 cytoplasm 39 0 cytoplasm cytoplasm Deuterostomia Opisthokonta Eukaryota SNX31 HGNC:28605 sorting nexin 31 Q8N9S9 nucleus 34 0 nucleus nucleus Mammalia Tetrapoda Holozoa SNX32 HGNC:26423 sorting nexin 32 Q86XE0 cytoplasm 32 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SNX33 HGNC:28468 sorting nexin 33 Q8WV41 cytoplasm 24 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SNX4 HGNC:11175 sorting nexin 4 O95219 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). Integral to membrane (GO:0016021); Cytoplasm (GO:0005737); Endosome (GO:0005768) 9819414,12668730,12668730 nucleus 37 0 cytoplasm. endosome multiple Deuterostomia Deuterostomia Eukaryota SNX5 HGNC:14969 sorting nexin 5 Q9Y5X3 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation. Endosome (GO:0005768); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11485546,11485546,11485546 cytoplasm 35 0 cytoplasm. endosome multiple Euteleostomi Euteleostomi Eukaryota SNX6 HGNC:14970 sorting nexin 6 Q9UNH7 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes. Only a minor proportion is seen in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 11591366,11591366,11591366,16730713 cytoplasm 45 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Bilateria Eukaryota SNX7 HGNC:14971 sorting nexin 7 Q9UNH6 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). cytoplasm 36 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota SNX8 HGNC:14972 sorting nexin 8 Q9Y5X2 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with retromer components. nucleus 48 0 nucleus nucleus Deuterostomia Opisthokonta Eukaryota SNX9 HGNC:14973 sorting nexin 9 Q9Y5X1 Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471); Clathrin-coated vesicle (GO:0030136) 15299020,15703209,15703209,15703209,15703209,15703209 cytoplasm 21 0 cytoplasm. golgi apparatus multiple Euteleostomi Bilateria Eukaryota SOAT1 HGNC:11177 sterol O-acyltransferase 1 P35610 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11483630,8407899,10623671,10623671 endoplasmic reticulum membrane 100 9 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Bilateria Eukaryota Eukaryota SOAT2 HGNC:11178 sterol O-acyltransferase 2 O75908 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 9756919,10846185,11071899 endoplasmic reticulum membrane 100 9 endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota SOBP HGNC:29256 sine oculis binding protein homolog (Drosophila) A7XYQ1 mitochondrion membrane 22 0 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Bilateria SOCS1 HGNC:19383 suppressor of cytokine signaling 1 O15524 Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. Cytoplasm (GO:0005737) 11297560 cytoplasm 22 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa SOCS2 HGNC:19382 suppressor of cytokine signaling 2 O14508 Cytoplasm (GO:0005737) 9727029 cytoplasm 13 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota SOCS3 HGNC:19391 suppressor of cytokine signaling 3 O14543 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12182826,11867182,12182826,11867182 nucleus 41 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa SOCS4 HGNC:19392 suppressor of cytokine signaling 4 Q8WXH5 cytoplasm 9 0 cytoplasm cytoplasm Eutheria Tetrapoda Metazoa SOCS5 HGNC:16852 suppressor of cytokine signaling 5 O75159 Cytoplasm (GO:0005737) 11553846 nucleus 77 0 cytoplasm cytoplasm Euteleostomi Bilateria Metazoa SOCS6 HGNC:16833 suppressor of cytokine signaling 6 O14544 cytoplasm 23 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Metazoa SOCS7 HGNC:29846 suppressor of cytokine signaling 7 O14512 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9344857,15242778,15242778,15242778 cytoplasm 24 0 cytoplasm. nucleus multiple Bilateria Bilateria NA SOD1 HGNC:11179 superoxide dismutase 1, soluble P00441 Cytoplasm. Note=The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. Peroxisome (GO:0005777); Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737) 1332049,1332049,14718574,1332049 cytoplasm 100 0 cytoplasm. nucleus. peroxisome. secreted multiple Opisthokonta Cell.Organisms Cell.Organisms SOD2 HGNC:11180 superoxide dismutase 2, mitochondrial P04179 Mitochondrion matrix. Mitochondrion (GO:0005739) 8633092,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SOD3 HGNC:11181 superoxide dismutase 3, extracellular P08294 Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium. Extracellular (GO:0005576) 12126755 secreted 100 0 secreted secreted Tetrapoda Tetrapoda Cell.Organisms SOGA1 HGNC:16111 suppressor of glucose, autophagy associated 1 O94964 C-terminal 80 kDa form: Secreted (By similarity). Note=Secreted in primary hepatocyte-conditioned media (By similarity). secreted 90 0 secreted secreted Euteleostomi Euteleostomi Bilateria SOGA3 HGNC:21494 SOGA family member 3 Q5TF21 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 39 1 secreted secreted Euteleostomi Deuterostomia Bilateria SOHLH1 HGNC:27845 spermatogenesis and oogenesis specific basic helix-loop-helix 1 Q5JUK2 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) nucleus 31 0 nucleus nucleus Eutheria Eutheria Eumetazoa SOHLH2 HGNC:26026 spermatogenesis and oogenesis specific basic helix-loop-helix 2 Q9NX45 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Theria Chordata Eumetazoa SON HGNC:11183 SON DNA binding protein P18583 Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10950926,1424986,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms SORBS1 HGNC:14565 sorbin and SH3 domain containing 1 Q9BX66 Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus (By similarity). Nucleus matrix (By similarity). Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. Cell junction (GO:0030054); Actin filament (GO:0005884); Extracellular matrix (GO:0005578) 10085297,17082770,17082770 cytoplasm 31 0 cytoplasm. secreted multiple Chordata Bilateria Eukaryota SORBS2 HGNC:24098 sorbin and SH3 domain containing 2 O94875 Cytoplasm, perinuclear region. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Cytoplasmic vesicle (GO:0016023); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9211900/10521485,15128873,10521485,10521485,17081983,10521485 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SORBS3 HGNC:30907 sorbin and SH3 domain containing 3 O60504 Isoform Alpha: Cell junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Isoform Beta: Cell junction (By similarity). Nucleus. Cytoplasm, cytoskeleton (By similarity). Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886);Focal adhesion (GO:0005925); Cell projection (GO:0042995); Cytoplasm (GO:0005737) 9885244,9885244,15184391/16831423,16831423,17081983 cytoplasm 26 0 cytoplasm. nucleus multiple Mammalia Bilateria Eukaryota SORCS1 HGNC:16697 sortilin-related VPS10 domain containing receptor 1 Q8WY21 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12482870 plasma membrane 39 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Eukaryota SORCS2 HGNC:16698 sortilin-related VPS10 domain containing receptor 2 Q96PQ0 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) plasma membrane 28 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Eukaryota SORCS3 HGNC:16699 sortilin-related VPS10 domain containing receptor 3 Q9UPU3 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 15710408 secreted 61 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Eukaryota SORD HGNC:11184 sorbitol dehydrogenase Q00796 Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 8487505,8487505 cytoplasm 9 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms SORL1 HGNC:11185 sortilin-related receptor, L(DLR class) A repeats containing Q92673 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 8940146,11294867,11557679,11294867,10375696,11557679 plasma membrane 24 1 cytoplasm. golgi apparatus. plasma membrane multiple Deuterostomia Eukaryota Cell.Organisms SORT1 HGNC:11186 sortilin 1 Q99523 Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Endosome membrane; Single-pass type I membrane protein (Potential). Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein (Potential). Nucleus membrane; Single-pass type I membrane protein (Potential). Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane; Single-pass type I membrane protein (Potential). Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin. Golgi apparatus (GO:0005794); Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783) 9013611,9927419,9013611,9927419 secreted 88 1 endoplasmic reticulum. endosome. golgi apparatus. plasma membrane multiple Euteleostomi Opisthokonta Eukaryota SOS1 HGNC:11187 son of sevenless homolog 1 (Drosophila) Q07889 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11560919,9447973 nucleus 20 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms SOS2 HGNC:11188 son of sevenless homolog 2 (Drosophila) Q07890 Cytoplasm (GO:0005737) 9372945 cytoplasm 16 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota SOST HGNC:13771 sclerostin Q9BQB4 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11181578 secreted 100 0 secreted secreted Human Human Eumetazoa SOSTDC1 HGNC:21748 sclerostin domain containing 1 Q6X4U4 Secreted. Extracellular (GO:0005576) 15020244 secreted 100 0 secreted secreted Tetrapoda Euteleostomi Eumetazoa SOWAHA HGNC:27033 sosondowah ankyrin repeat domain family member A Q2M3V2 nucleus 36 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SOWAHB HGNC:32958 sosondowah ankyrin repeat domain family member B A6NEL2 nucleus 26 0 nucleus nucleus Theria Euteleostomi Cell.Organisms SOWAHC HGNC:26149 sosondowah ankyrin repeat domain family member C Q53LP3 nucleus 29 0 nucleus nucleus Homininae Euteleostomi Cell.Organisms SOWAHD HGNC:32960 sosondowah ankyrin repeat domain family member D A6NJG2 nucleus 26 0 nucleus nucleus Euarchontoglires Euarchontoglires Holozoa SOX1 HGNC:11189 SRY (sex determining region Y)-box 1 O00570 Nucleus (Probable). Nucleus (GO:0005634) 9337405 nucleus 61 0 nucleus nucleus Human Euteleostomi Eukaryota SOX10 HGNC:11190 SRY (sex determining region Y)-box 10 P56693 Cytoplasm. Nucleus. Nucleus (GO:0005634) 9760192 nucleus 98 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota SOX11 HGNC:11191 SRY (sex determining region Y)-box 11 P35716 Nucleus (By similarity). Nucleus (GO:0005634) 12637543,9632656 nucleus 79 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SOX12 HGNC:11198 SRY (sex determining region Y)-box 12 O15370 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Theria Eukaryota SOX13 HGNC:11192 SRY (sex determining region Y)-box 13 Q9UN79 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10871192,10871192 nucleus 88 0 cytoplasm. nucleus multiple Human Euteleostomi Eukaryota SOX14 HGNC:11193 SRY (sex determining region Y)-box 14 O95416 Nucleus (By similarity). Nucleus (GO:0005634) 9925951 nucleus 71 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota SOX15 HGNC:11196 SRY (sex determining region Y)-box 15 O60248 Nucleus (Potential). Nucleus (GO:0005634) nucleus 61 0 nucleus nucleus Eutheria Eutheria Eukaryota SOX17 HGNC:18122 SRY (sex determining region Y)-box 17 Q9H6I2 Nucleus (By similarity). Nucleus (GO:0005634) 11786926,15163629 nucleus 81 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SOX18 HGNC:11194 SRY (sex determining region Y)-box 18 P35713 Nucleus (Potential). Nucleus (GO:0005634) 11554755 nucleus 85 0 nucleus nucleus Theria Euteleostomi Eukaryota SOX2 HGNC:11195 SRY (sex determining region Y)-box 2 P48431 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Opisthokonta Eukaryota SOX21 HGNC:11197 SRY (sex determining region Y)-box 21 Q9Y651 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 76 0 nucleus nucleus Theria Bilateria Eukaryota SOX3 HGNC:11199 SRY (sex determining region Y)-box 3 P41225 Nucleus. Nucleus (GO:0005634) 14585968 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SOX30 HGNC:30635 SRY (sex determining region Y)-box 30 O94993 Nucleus. Nucleus (GO:0005634) 10359848 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota SOX4 HGNC:11200 SRY (sex determining region Y)-box 4 Q06945 Nucleus. Nucleus (GO:0005634) 7706298 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota SOX5 HGNC:11201 SRY (sex determining region Y)-box 5 P35711 Nucleus (By similarity). Nucleus (GO:0005634) 8078769,11585348 nucleus 96 0 nucleus nucleus Deuterostomia Bilateria Eukaryota SOX6 HGNC:16421 SRY (sex determining region Y)-box 6 P35712 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota SOX7 HGNC:18196 SRY (sex determining region Y)-box 7 Q9BT81 Nucleus (By similarity). Cytoplasm. Nucleus (GO:0005634) 11691915 nucleus 44 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota SOX8 HGNC:11203 SRY (sex determining region Y)-box 8 P57073 Nucleus (Potential). Nucleus (GO:0005634) 10662550 nucleus 45 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SOX9 HGNC:11204 SRY (sex determining region Y)-box 9 P48436 Nucleus (Potential). Nucleus (GO:0005634) 8001137 nucleus 58 0 nucleus nucleus Euteleostomi Bilateria Eukaryota SP1 HGNC:11205 Sp1 transcription factor P08047 Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location. Nucleus (GO:0005634) 8845379,16339759,15657065,15661808 nucleus 51 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Eukaryota SP100 HGNC:11206 SP100 nuclear antigen P23497 Nucleus. Nucleus, PML body. Cytoplasm. Isoform Sp100-C: Nucleus. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654) 17081983,17081983/9636146,8695863,2258622,11313457,15247905,17081983,8695863,17245429,17081983,15017387 nucleus 76 0 cytoplasm. nucleus multiple Homininae Eutheria Eukaryota SP110 HGNC:5401 SP110 nuclear body protein Q9HB58 Nucleus. Note=Found in the nuclear body. Nucleus (GO:0005634); Nucleolus (GO:0005730) 7693701,10913195,10388521,10388521 nucleus 100 0 nucleus nucleus Eutheria Eutheria Metazoa SP140 HGNC:17133 SP140 nuclear body protein Q13342 Nucleus. Cytoplasm. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus. Nucleus (GO:0005634) 8695863 nucleus 24 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota SP140L HGNC:25105 SP140 nuclear body protein-like Q9H930 nucleus 33 0 nucleus nucleus Human Catarrhini Eukaryota SP2 HGNC:11207 Sp2 transcription factor Q02086 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota SP3 HGNC:11208 Sp3 transcription factor Q02447 Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies. Nucleus (GO:0005634); Nuclear matrix (GO:0016363) 8845379,15247228,16339759,15987735 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota SP4 HGNC:11209 Sp4 transcription factor Q02446 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SP5 HGNC:14529 Sp5 transcription factor Q6BEB4 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 97 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SP6 HGNC:14530 Sp6 transcription factor Q3SY56 Nucleus (By similarity). Nucleus (GO:0005634) 14551215 nucleus 95 0 nucleus nucleus Theria Euteleostomi Eukaryota SP7 HGNC:17321 Sp7 transcription factor Q8TDD2 Nucleus (By similarity). Nucleus (GO:0005634) 11792318 nucleus 94 0 nucleus nucleus Eutheria Euteleostomi Eukaryota SP8 HGNC:19196 Sp8 transcription factor Q8IXZ3 Nucleus (Probable). Nucleus (GO:0005634) 15533246 nucleus 58 0 nucleus nucleus Theria Bilateria Eukaryota SP9 HGNC:30690 Sp9 transcription factor P0CG40 Nucleus (Probable). nucleus 70 1 nucleus nucleus NA NA Eukaryota SPA17 HGNC:11210 sperm autoantigenic protein 17 Q15506 Membrane; Peripheral membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7578682,14712480,14712480 nucleus 20 0 cytoplasm. nucleus multiple Chordata Chordata Eumetazoa SPACA1 HGNC:14967 sperm acrosome associated 1 Q9HBV2 Membrane; Single-pass type I membrane protein (Potential). Lysosome (GO:0005764) 11870081 secreted 27 1 lysosome lysosome Amniota Amniota Craniata SPACA3 HGNC:16260 sperm acrosome associated 3 Q8IXA5 Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type II membrane protein (Probable). Isoform 2: Secreted (Potential). Lysosome (GO:0005764) 12606493 secreted 40 1 lysosome lysosome Eutheria Eutheria Bilateria SPACA4 HGNC:16441 sperm acrosome associated 4 Q8TDM5 Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes. Lysosome (GO:0005764); Plasma membrane (GO:0005886) 12788941,12788941 plasma membrane 24 0 lysosome lysosome Mammalia Euteleostomi Euteleostomi SPACA5 HGNC:31353 sperm acrosome associated 5 Q96QH8 Secreted (Probable). Extracellular (GO:0005576) secreted 41 0 secreted secreted Euarchontoglires Eutheria NA SPACA5B HGNC:19142 sperm acrosome associated 5B Q96QH8 Secreted (Probable). secreted 41 0 secreted secreted Euarchontoglires Eutheria NA SPACA7 HGNC:29575 sperm acrosome associated 7 Q96KW9 Secreted (Potential). nucleus 51 0 nucleus nucleus Euarchontoglires Euarchontoglires Boreoeutheria SPAG1 HGNC:11212 sperm associated antigen 1 Q07617 Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11517287,11517287 cytoplasm 100 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms SPAG11A HGNC:33342 sperm associated antigen 11A Q6PDA7 Secreted. Acrosome (GO:0001669) 10698202 secreted 100 0 lysosome. secreted multiple Eutheria Eutheria Opisthokonta SPAG11B HGNC:14534 sperm associated antigen 11B Q08648 Secreted. Extracellular (GO:0005576); Acrosome (GO:0001669) 8167223,15229135,10698202 secreted 100 0 lysosome. secreted multiple Human Human Opisthokonta SPAG16 HGNC:23225 sperm associated antigen 16 Q8N0X2 Cytoplasm (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). Acrosome (GO:0001669) 12391165 cytoplasm 70 0 lysosome lysosome Deuterostomia Eukaryota Cell.Organisms SPAG17 HGNC:26620 sperm associated antigen 17 Q6Q759 Cytoplasm (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Note=Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules (By similarity). cytoplasm 66 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota SPAG4 HGNC:11214 sperm associated antigen 4 Q9NPE6 Membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Note=In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Microtubule (GO:0005874) 10373309 nucleus membrane 26 3 cytoplasm cytoplasm Theria Amniota Eukaryota SPAG5 HGNC:13452 sperm associated antigen 5 Q96R06 Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Note=In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Microtubule (GO:0005874) 11724960,11549262,11724960,11549262,12356910,15561729 nucleus 14 0 cytoplasm. nucleus multiple Mammalia Mammalia Euteleostomi SPAG6 HGNC:11215 sperm associated antigen 6 O75602 Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Associated with microtubules. Detected on the sperm flagellum. Cell projection (GO:0042995) 10493827 nucleus 5 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms SPAG7 HGNC:11216 sperm associated antigen 7 O75391 Nucleus (Potential). nucleus 67 0 nucleus nucleus Theria Bilateria Holozoa SPAG8 HGNC:14105 sperm associated antigen 8 Q99932 Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Acrosomal region of the head of mature sperm cells. Cytoplasm (GO:0005737); Acrosome (GO:0001669); Microtubule (GO:0005874); Centrosome (GO:0005813) 15014887,8788182,15014887,15014887 secreted 33 0 cytoplasm. lysosome multiple Euarchontoglires Deuterostomia Metazoa SPAG9 HGNC:14524 sperm associated antigen 9 O60271 Cytoplasm. Cytoplasm, perinuclear region. Isoform 5: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 15987681,17081983,9480848,17081983 cytoplasm 96 0 cytoplasm. nucleus multiple Bilateria Bilateria Metazoa SPAM1 HGNC:11217 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) P38567 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 8195297 secreted 19 2 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa SPANXA1 HGNC:11218 sperm protein associated with the nucleus, X-linked, family member A1 Q9NS26 Cytoplasm. Nucleus. Note=Associated with nuclear craters. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10906052,10906052 nucleus 47 0 cytoplasm. nucleus multiple Homininae Homininae NA SPANXA2 HGNC:14328 SPANX family, member A2 Q9NS26 Cytoplasm. Nucleus. Note=Associated with nuclear craters. nucleus 47 0 cytoplasm. nucleus multiple Homininae Homininae NA SPANXB1 HGNC:14329 SPANX family, member B1 Q9NS25 Cytoplasm. Nucleus. Note=Associated with nuclear craters. nucleus 49 0 cytoplasm. nucleus multiple NA NA NA SPANXB2 HGNC:14330 SPANX family, member B2 Q9NS25 Cytoplasm. Nucleus. Note=Associated with nuclear craters. Cytoplasm (GO:0005737) 11133693 nucleus 49 0 cytoplasm. nucleus multiple NA NA Primates SPANXC HGNC:14331 SPANX family, member C Q9NY87 Cytoplasm. Nucleus. Note=Associated with nuclear craters. Nucleus (GO:0005634) 10626816 nucleus 47 0 cytoplasm. nucleus multiple Homininae Homininae NA SPANXD HGNC:14332 SPANX family, member D Q9BXN6 Cytoplasm (By similarity). Nucleus (By similarity). Note=Associated with nuclear craters (By similarity). Nucleus (GO:0005634) 11133693 nucleus 48 0 nucleus nucleus Homininae Homininae NA SPANXE HGNC:18408 SPANX family, member E Q8TAD1 Cytoplasm (By similarity). Nucleus (By similarity). Note=Associated with nuclear craters (By similarity). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus NA NA NA SPANXF1 HGNC:18409 SPANX family, member F1 Q9NS25 Cytoplasm. Nucleus. Note=Associated with nuclear craters. nucleus 49 0 cytoplasm. nucleus multiple NA NA NA SPANXN1 HGNC:33174 SPANX family, member N1 Q5VSR9 nucleus 49 0 nucleus nucleus Human Human NA SPANXN2 HGNC:33175 SPANX family, member N2 Q5MJ10 mitochondrion 33 0 mitochondrion mitochondrion Catarrhini Catarrhini Boreoeutheria SPANXN3 HGNC:33176 SPANX family, member N3 Q5MJ09 nucleus 71 0 nucleus nucleus Catarrhini Catarrhini NA SPANXN4 HGNC:33177 SPANX family, member N4 Q5MJ08 nucleus 46 0 nucleus nucleus Catarrhini Catarrhini Primates SPANXN5 HGNC:33178 SPANX family, member N5 Q5MJ07 nucleus 49 0 nucleus nucleus Human Human NA SPARC HGNC:11219 secreted protein, acidic, cysteine-rich (osteonectin) P09486 Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 6368555,3489235,3400777 secreted 46 0 cytoplasm. secreted multiple Bilateria Bilateria Eumetazoa SPARCL1 HGNC:11220 SPARC-like 1 (hevin) Q14515 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 7600298,8626806,12538579 secreted 59 0 secreted secreted Amniota Bilateria Eumetazoa SPAST HGNC:11233 spastin Q9UBP0 Membrane; Single-pass membrane protein (Potential). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Isoform 3 is the main endosomal form. Nucleus (GO:0005634); Centrosome (GO:0005813); Cytoskeleton (GO:0005856); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 10610178,15269182,15269182,11809724,15269182,11809724,11809724,11809724/15269182,11809724,11809724 nucleus 31 3 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. nucleus multiple Bilateria Eukaryota Cell.Organisms SPATA1 HGNC:14682 spermatogenesis associated 1 Q5VX52 secreted 18 0 secreted secreted Eutheria Chordata NA SPATA12 HGNC:23221 spermatogenesis associated 12 Q7Z6I5 secreted 44 0 secreted secreted Homininae Homininae Eutheria SPATA13 HGNC:23222 spermatogenesis associated 13 Q96N96 Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. cytoplasm 55 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota SPATA16 HGNC:29935 spermatogenesis associated 16 Q9BXB7 Golgi apparatus. Note=Localized to the perinuclear region. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12529416,12529416,16188874 golgi apparatus 100 0 cytoplasm. golgi apparatus. secreted multiple Amniota Amniota Amniota SPATA17 HGNC:25184 spermatogenesis associated 17 Q96L03 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15756417,16395525,17081983 cytoplasm 70 1 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota SPATA18 HGNC:29579 spermatogenesis associated 18 Q8TC71 Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane. cytoplasm 5 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eumetazoa SPATA19 HGNC:30614 spermatogenesis associated 19 Q7Z5L4 Mitochondrion outer membrane (By similarity). Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15139970,17081983 nucleus 18 0 mitochondrion. nucleus multiple Mammalia Mammalia Mammalia SPATA2 HGNC:14681 spermatogenesis associated 2 Q9UM82 Nucleus. Cytoplasm (GO:0005737) 10222154 nucleus 100 1 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa SPATA20 HGNC:26125 spermatogenesis associated 20 Q8TB22 Secreted (Potential). cytoplasm 51 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SPATA21 HGNC:28026 spermatogenesis associated 21 Q7Z572 cytoplasm 23 0 cytoplasm cytoplasm Eutheria Eutheria Eukaryota SPATA22 HGNC:30705 spermatogenesis associated 22 Q8NHS9 nucleus 51 0 nucleus nucleus Amniota Amniota Metazoa SPATA24 HGNC:27322 spermatogenesis associated 24 Q86W54 Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin (By similarity). cytoplasm 8 0 cytoplasm. nucleus multiple NA NA Eumetazoa SPATA25 HGNC:16158 spermatogenesis associated 25 Q9BR10 Membrane; Single-pass membrane protein (Potential). secreted 71 0 secreted secreted Theria Theria Mammalia SPATA2L HGNC:28393 spermatogenesis associated 2-like Q8IUW3 cytoplasm 11 0 cytoplasm cytoplasm Mammalia Mammalia Craniata SPATA3 HGNC:17884 spermatogenesis associated 3 Q8NHX4 nucleus 55 0 nucleus nucleus Euarchontoglires Eutheria Eutheria SPATA31A1 HGNC:23394 SPATA31 subfamily A, member 1 Q5TZJ5 Membrane; Single-pass membrane protein (Potential). secreted 13 1 secreted secreted Eutheria Eutheria Eutheria SPATA31A2 HGNC:32002 SPATA31 subfamily A, member 2 Q5RGS2 Membrane; Single-pass membrane protein (Potential). secreted 13 1 secreted secreted Eutheria Eutheria Eutheria SPATA31A3 HGNC:32003 SPATA31 subfamily A, member 3 Q5VYP0 Membrane; Single-pass membrane protein (Potential). nucleus 93 1 nucleus nucleus Eutheria Eutheria Eutheria SPATA31A4 HGNC:32004 SPATA31 subfamily A, member 4 Q4VX67 Membrane; Single-pass membrane protein (Potential). nucleus 93 1 nucleus nucleus NA NA Eutheria SPATA31A5 HGNC:32005 SPATA31 subfamily A, member 5 Q5VU36 Membrane; Single-pass membrane protein (Potential). nucleus 93 1 nucleus nucleus NA NA Eutheria SPATA31A6 HGNC:32006 SPATA31 subfamily A, member 6 Q5VVP1 Membrane; Single-pass membrane protein (Potential). secreted 13 1 secreted secreted Eutheria Eutheria Eutheria SPATA31A7 HGNC:32007 SPATA31 subfamily A, member 7 Q8IWB4 Membrane; Single-pass membrane protein (Potential). nucleus 92 1 nucleus nucleus NA NA Eutheria SPATA31D1 HGNC:37283 SPATA31 subfamily D, member 1 Q6ZQQ2 Membrane; Single-pass membrane protein (Potential). nucleus 89 1 nucleus nucleus Eutheria Eutheria Amniota SPATA31E1 HGNC:26672 SPATA31 subfamily E, member 1 Q6ZUB1 Membrane; Single-pass membrane protein (Potential). nucleus 27 1 nucleus nucleus Eutheria Eutheria Eutheria SPATA32 HGNC:26349 spermatogenesis associated 32 Q96LK8 nucleus 56 0 nucleus nucleus Eutheria Eutheria Eutheria SPATA33 HGNC:26463 spermatogenesis associated 33 Q96N06 nucleus 51 0 nucleus nucleus Euarchontoglires Eutheria Eutheria SPATA4 HGNC:17333 spermatogenesis associated 4 Q8NEY3 Nucleus (GO:0005634) 15158438 cytoplasm 20 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota SPATA45 HGNC:33709 spermatogenesis associated 45 Q537H7 nucleus 9 0 nucleus nucleus Eutheria Eutheria Eutheria SPATA5 HGNC:18119 spermatogenesis associated 5 Q8NB90 Cytoplasm (By similarity). Mitochondrion (By similarity). Mitochondrion (GO:0005739) 10734318 cytoplasm 38 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SPATA5L1 HGNC:28762 spermatogenesis associated 5-like 1 Q9BVQ7 Cytoplasm (Potential). nucleus 26 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms SPATA6 HGNC:18309 spermatogenesis associated 6 Q9NWH7 Secreted (Potential). Cytoplasm (GO:0005737) 11735130 nucleus 45 0 cytoplasm cytoplasm Chordata Chordata Eumetazoa SPATA6L HGNC:25472 spermatogenesis associated 6-like Q8N4H0 nucleus 54 0 nucleus nucleus Mammalia Bilateria Eumetazoa SPATA7 HGNC:20423 spermatogenesis associated 7 Q9P0W8 nucleus 90 0 nucleus nucleus Amniota Deuterostomia Eumetazoa SPATA8 HGNC:28676 spermatogenesis associated 8 Q6RVD6 secreted 10 0 secreted secreted Homininae Homininae Boreoeutheria SPATA9 HGNC:22988 spermatogenesis associated 9 Q9BWV2 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 12493713 mitochondrion 47 1 plasma membrane plasma membrane Theria Theria Amniota SPATC1 HGNC:30510 spermatogenesis and centriole associated 1 Q76KD6 Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm. Centrosome (GO:0005813) 15280373 cytoplasm 51 0 cytoplasm cytoplasm Mammalia Mammalia NA SPATC1L HGNC:1298 spermatogenesis and centriole associated 1-like Q9H0A9 cytoplasm 40 0 cytoplasm cytoplasm Mammalia Euteleostomi Bilateria SPATS1 HGNC:22957 spermatogenesis associated, serine-rich 1 Q496A3 nucleus 53 0 nucleus nucleus NA NA Eumetazoa SPATS2 HGNC:18650 spermatogenesis associated, serine-rich 2 Q86XZ4 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11944913 cytoplasm 80 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa SPATS2L HGNC:24574 spermatogenesis associated, serine-rich 2-like Q9NUQ6 Cytoplasm. Nucleus, nucleolus. Note=During oxidative stress as well as UV irradiation, energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking NPM1. Nucleus (GO:0005634) 15561729 cytoplasm 30 0 cytoplasm. nucleus multiple Theria Amniota Opisthokonta SPC24 HGNC:26913 SPC24, NDC80 kinetochore complex component Q8NBT2 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. Kinetochore (GO:0000776); Nucleus (GO:0005634) 15824131,14738735,15561729,14699129 nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Eumetazoa SPC25 HGNC:24031 SPC25, NDC80 kinetochore complex component Q9HBM1 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. Nucleus (GO:0005634); Kinetochore (GO:0000776) 14699129,14738735,14738735,15561729 nucleus 100 0 nucleus nucleus Tetrapoda Eukaryota NA SPCS1 HGNC:23401 signal peptidase complex subunit 1 homolog (S. cerevisiae) Q9Y6A9 Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi- pass membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789) 8632014 endoplasmic reticulum membrane 61 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota SPCS2 HGNC:28962 signal peptidase complex subunit 2 homolog (S. cerevisiae) Q15005 Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi- pass membrane protein (By similarity). Microsome (GO:0005792) endoplasmic reticulum membrane 89 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota SPCS3 HGNC:26212 signal peptidase complex subunit 3 homolog (S. cerevisiae) P61009 Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). endoplasmic reticulum membrane 21 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota SPDEF HGNC:17257 SAM pointed domain containing ETS transcription factor O95238 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Bilateria Bilateria Metazoa SPDL1 HGNC:26010 spindle apparatus coiled-coil protein 1 Q96EA4 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. nucleus 15 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Holozoa SPDYA HGNC:30613 speedy/RINGO cell cycle regulator family member A Q5MJ70 Nucleus. Nucleus (GO:0005634) 11980914 nucleus 100 0 nucleus nucleus Deuterostomia Deuterostomia Holozoa SPDYC HGNC:32681 speedy/RINGO cell cycle regulator family member C Q5MJ68 Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase. cytoplasm 100 0 cytoplasm cytoplasm Theria Theria Holozoa SPDYE1 HGNC:16408 speedy/RINGO cell cycle regulator family member E1 Q8NFV5 cytoplasm 35 0 cytoplasm cytoplasm Catarrhini Mammalia Metazoa SPDYE2 HGNC:33841 speedy/RINGO cell cycle regulator family member E2 Q495Y8 cytoplasm 31 0 cytoplasm cytoplasm Human Human Metazoa SPDYE2B HGNC:48334 speedy/RINGO cell cycle regulator family member E2B A6NHP3 cytoplasm 31 0 cytoplasm cytoplasm NA NA Metazoa SPDYE3 HGNC:35462 speedy/RINGO cell cycle regulator family member E3 A6NKU9 cytoplasm 35 0 cytoplasm cytoplasm Homininae Homininae Metazoa SPDYE4 HGNC:35463 speedy/RINGO cell cycle regulator family member E4 A6NLX3 cytoplasm 28 0 cytoplasm cytoplasm Eutheria Eutheria Metazoa SPECC1 HGNC:30615 sperm antigen with calponin homology and coiled-coil domains 1 Q5M775 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota SPECC1L HGNC:29022 sperm antigen with calponin homology and coiled-coil domains 1-like Q69YQ0 Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell junction, gap junction. Note=Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center. nucleus 30 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota SPEF1 HGNC:15874 sperm flagellar 1 Q9Y4P9 Cytoplasm. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). cytoplasm 50 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota SPEF2 HGNC:26293 sperm flagellar 2 Q9C093 cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms SPEG HGNC:16901 SPEG complex locus Q15772 Isoform 3: Nucleus. Nucleus (GO:0005634) 8663449,10318857 nucleus 100 0 nucleus nucleus Amniota Bilateria Cell.Organisms SPEM1 HGNC:32429 spermatid maturation 1 Q8N4L4 Membrane; Single-pass membrane protein (Potential). Cytoplasm (By similarity). nucleus 48 1 nucleus nucleus Eutheria Mammalia Eutheria SPEN HGNC:17575 spen family transcriptional repressor Q96T58 Nucleus. Note=Associates with chromatin. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11331609,12374742,12374742 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota SPERT HGNC:30720 spermatid associated Q8NA61 Cytoplasm (GO:0005737) 12204287 cytoplasm 16 0 cytoplasm cytoplasm Theria Amniota Amniota SPESP1 HGNC:15570 sperm equatorial segment protein 1 Q6UW49 Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase). Lysosome (GO:0005764) 12773409 cytoplasm 20 0 lysosome lysosome NA NA Mammalia SPG11 HGNC:11226 spastic paraplegia 11 (autosomal recessive) Q96JI7 Membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytosol. Nucleus. Note=Mainly cytoplasmic. Cytosol (GO:0005829); Perinuclear region (GO:0048471); Nucleolus (GO:0005730); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 17322883,17322883,17322883,17322883,17322883 nucleus 80 2 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Bilateria Eukaryota SPG20 HGNC:18514 spastic paraplegia 20 (Troyer syndrome) Q8N0X7 Cytoplasm. Note=Transiently associated with endosomes. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Microtubule (GO:0005874) 16945107,16945107,16945107 cytoplasm 100 0 cytoplasm. mitochondrion multiple Chordata Eukaryota Eukaryota SPG21 HGNC:20373 spastic paraplegia 21 (autosomal recessive, Mast syndrome) Q9NZD8 Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network. Cytoplasm (GO:0005737); Endosome (GO:0005768); Golgi apparatus (GO:0005794) 11113139,11113139,11113139 mitochondrion 73 0 cytoplasm. endosome. golgi apparatus multiple Deuterostomia Eukaryota Cell.Organisms SPG7 HGNC:11237 spastic paraplegia 7 (pure and complicated autosomal recessive) Q9UQ90 Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 9635427 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Human Eukaryota Cell.Organisms SPHAR HGNC:16957 S-phase response (cyclin related) Q15513 Nucleus (GO:0005634) 7799938 secreted 74 1 nucleus nucleus Human Catarrhini Homo SPHK1 HGNC:11240 sphingosine kinase 1 Q9NYA1 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Lysosome (GO:0005764); Cytosol (GO:0005829); Membrane fraction (GO:0005624) 15710602,15623571,12080051,15693752,15623571,15710602,15265887,12080051,11856736,11856736 mitochondrion 13 1 cytoplasm. lysosome. nucleus. plasma membrane multiple Opisthokonta Eukaryota Cell.Organisms SPHK2 HGNC:18859 sphingosine kinase 2 Q9NRA0 Isoform 1: Cytoplasm. Membrane. Isoform 2: Lysosome membrane. Cytoplasm (GO:0005737) 10751414 mitochondrion 19 0 cytoplasm cytoplasm Eutheria Eukaryota Cell.Organisms SPHKAP HGNC:30619 SPHK1 interactor, AKAP domain containing Q2M3C7 Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm. Cytoplasm (GO:0005737) 12080051 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria SPI1 HGNC:11241 spleen focus forming virus (SFFV) proviral integration oncogene P17947 Nucleus. Nucleus (GO:0005634) 8219191 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa SPIB HGNC:11242 Spi-B transcription factor (Spi-1/PU.1 related) Q01892 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8670269,8670269 nucleus 36 0 cytoplasm. nucleus multiple Euarchontoglires Euteleostomi NA SPIC HGNC:29549 Spi-C transcription factor (Spi-1/PU.1 related) Q8N5J4 Nucleus (Probable). Nucleus (GO:0005634) 12459275 nucleus 28 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa SPICE1 HGNC:25083 spindle and centriole associated protein 1 Q8N0Z3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Cytoplasm (GO:0005737) 17081983 cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Metazoa SPIDR HGNC:28971 scaffolding protein involved in DNA repair Q14159 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi NA SPIN1 HGNC:11243 spindlin 1 Q9Y657 Nucleus. Cytoplasm (GO:0005737) 9053325 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata SPIN2A HGNC:20694 spindlin family, member 2A Q99865 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12145692,12145692 nucleus 100 0 cytoplasm. nucleus multiple Human Eutheria Craniata SPIN2B HGNC:33147 spindlin family, member 2B Q9BPZ2 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12145692,12145692 nucleus 100 0 cytoplasm. nucleus multiple Human Eutheria Eukaryota SPIN3 HGNC:27272 spindlin family, member 3 Q5JUX0 nucleus 82 0 nucleus nucleus Euteleostomi Euteleostomi Craniata SPIN4 HGNC:27040 spindlin family, member 4 Q56A73 nucleus 72 0 nucleus nucleus Eutheria Eutheria NA SPINK1 HGNC:11244 serine peptidase inhibitor, Kazal type 1 P00995 Secreted. Extracellular (GO:0005576) 2110056 secreted 100 0 secreted secreted Mammalia Mammalia Eumetazoa SPINK13 HGNC:27200 serine peptidase inhibitor, Kazal type 13 (putative) Q1W4C9 Secreted (By similarity). Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). secreted 41 0 secreted secreted Homininae Euarchontoglires Amniota SPINK14 HGNC:33825 serine peptidase inhibitor, Kazal type 14 (putative) Q6IE38 Secreted (Potential). secreted 33 0 secreted secreted Euarchontoglires Euarchontoglires Eumetazoa SPINK2 HGNC:11245 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) P20155 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 1801743,791787 secreted 100 0 secreted secreted Theria Bilateria Eumetazoa SPINK4 HGNC:16646 serine peptidase inhibitor, Kazal type 4 O60575 Secreted (By similarity). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 1400298,1400298 secreted 67 0 cytoplasm. secreted multiple Amniota Amniota Bilateria SPINK5 HGNC:15464 serine peptidase inhibitor, Kazal type 5 Q9NQ38 Secreted. Extracellular (GO:0005576) 10419450 secreted 100 0 secreted secreted Amniota Amniota Eukaryota SPINK6 HGNC:29486 serine peptidase inhibitor, Kazal type 6 Q6UWN8 Secreted (Potential). secreted 81 0 secreted secreted Mammalia Mammalia Eumetazoa SPINK7 HGNC:24643 serine peptidase inhibitor, Kazal type 7 (putative) P58062 Secreted (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12646258,12646258 secreted 44 0 cytoplasm. nucleus multiple Mammalia Mammalia Eukaryota SPINK8 HGNC:33160 serine peptidase inhibitor, Kazal type 8 (putative) P0C7L1 Secreted (Potential). secreted 41 0 secreted secreted NA NA Amniota SPINK9 HGNC:32951 serine peptidase inhibitor, Kazal type 9 Q5DT21 Secreted (Potential). secreted 51 0 secreted secreted Catarrhini Catarrhini Eumetazoa SPINT1 HGNC:11246 serine peptidase inhibitor, Kunitz type 1 O43278 Secreted. Soluble fraction (GO:0005625); Extracellular (GO:0005576); Membrane fraction (GO:0005624) 10544273,9045658,9045658 secreted 100 1 secreted secreted Euteleostomi Euteleostomi Cell.Organisms SPINT2 HGNC:11247 serine peptidase inhibitor, Kunitz type, 2 O43291 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576); Lysosome (GO:0005764) 9045658,9045658,16364318 secreted 34 1 lysosome. plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms SPINT3 HGNC:11248 serine peptidase inhibitor, Kunitz type, 3 P49223 Secreted (Probable). secreted 39 0 secreted secreted Catarrhini Euarchontoglires Cell.Organisms SPINT4 HGNC:16130 serine peptidase inhibitor, Kunitz type 4 Q6UDR6 Secreted (Probable). secreted 45 0 secreted secreted Eutheria Eutheria Cell.Organisms SPIRE1 HGNC:30622 spire-type actin nucleation factor 1 Q08AE8 Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, co-localised with Rab11. Golgi apparatus (GO:0005794) 11747823 nucleus 85 0 cytoplasm. golgi apparatus multiple Chordata Chordata Eumetazoa SPIRE2 HGNC:30623 spire-type actin nucleation factor 2 Q8WWL2 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). nucleus 80 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa SPN HGNC:11249 sialophorin P16150 Membrane; Single-pass type I membrane protein. Cell surface (GO:0009986); Nucleus (GO:0005634) 15003504,10908570,15003504 nucleus 15 1 nucleus nucleus Eutheria Eutheria Deuterostomia SPNS1 HGNC:30621 spinster homolog 1 (Drosophila) Q9H2V7 Mitochondrion inner membrane; Multi-pass membrane protein. Note=Colocalizes with SDHB. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 12815463,12815463 mitochondrion membrane 100 12 cytoplasm. mitochondrion. mitochondrion membrane multiple Bilateria Cell.Organisms Cell.Organisms SPNS2 HGNC:26992 spinster homolog 2 (Drosophila) Q8IVW8 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 44 12 mitochondrion membrane mitochondrion membrane Bilateria Cell.Organisms Cell.Organisms SPNS3 HGNC:28433 spinster homolog 3 (Drosophila) Q6ZMD2 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 42 12 mitochondrion membrane mitochondrion membrane Amniota Euteleostomi Cell.Organisms SPO11 HGNC:11250 SPO11 meiotic protein covalently bound to DSB Q9Y5K1 Nucleus (By similarity). nucleus 23 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms SPOCD1 HGNC:26338 SPOC domain containing 1 Q6ZMY3 nucleus 15 0 nucleus nucleus Human Mammalia Eukaryota SPOCK1 HGNC:11251 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 Q08629 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8626787 secreted 100 0 secreted secreted Amniota Euteleostomi Eumetazoa SPOCK2 HGNC:13564 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 Q92563 Secreted, extracellular space, extracellular matrix (Probable). Extracellular (GO:0005576); Nucleus (GO:0005634) 10386950,17081983 secreted 41 0 nucleus. secreted multiple Mammalia Euteleostomi Eumetazoa SPOCK3 HGNC:13565 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 Q9BQ16 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11751414 secreted 100 0 secreted secreted Amniota Bilateria Metazoa SPON1 HGNC:11252 spondin 1, extracellular matrix protein Q9HCB6 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 11368520 secreted 96 0 secreted secreted Bilateria Bilateria NA SPON2 HGNC:11253 spondin 2, extracellular matrix protein Q9BUD6 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) 10512675 secreted 84 0 secreted secreted Euteleostomi Bilateria Cell.Organisms SPOP HGNC:11254 speckle-type POZ protein O43791 Nucleus. Nucleus speckle. Nucleus (GO:0005634) 15240113,12183056,15121856,9414087 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota SPOPL HGNC:27934 speckle-type POZ protein-like Q6IQ16 Nucleus (By similarity). nucleus 81 0 nucleus nucleus Chordata Eukaryota Eukaryota SPP1 HGNC:11255 secreted phosphoprotein 1 P10451 Secreted. Extracellular (GO:0005576) 12847283,16199891 secreted 100 0 secreted secreted Amniota Amniota Amniota SPP2 HGNC:11256 secreted phosphoprotein 2, 24kDa Q13103 Secreted. Extracellular (GO:0005576) 7814406 secreted 100 0 secreted secreted Amniota Amniota Euteleostomi SPPL2A HGNC:30227 signal peptide peptidase like 2A Q8TCT8 Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane; Multi-pass membrane protein (By similarity). Cell membrane. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane. golgi apparatus membrane 36 9 golgi apparatus membrane golgi apparatus membrane NA NA Eukaryota SPPL2B HGNC:30627 signal peptide peptidase like 2B Q8TCT7 Golgi apparatus membrane; Multi-pass membrane protein. Note=targeted through the entire secretory pathway to endosomes/lysosomes. golgi apparatus membrane 100 9 golgi apparatus membrane golgi apparatus membrane NA NA Eukaryota SPPL2C HGNC:28902 signal peptide peptidase like 2C Q8IUH8 Membrane; Multi-pass membrane protein (Probable). Endoplasmic reticulum membrane; Multi-pass membrane protein. golgi apparatus membrane 44 9 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eukaryota SPPL3 HGNC:30424 signal peptide peptidase like 3 Q8TCT6 Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Restricted to the early secretory compartment. endoplasmic reticulum membrane 22 9 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eukaryota SPR HGNC:11257 sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) P35270 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms SPRED1 HGNC:20249 sprouty-related, EVH1 domain containing 1 Q7Z699 Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions. secreted 92 1 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa SPRED2 HGNC:17722 sprouty-related, EVH1 domain containing 2 Q7Z698 Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 11493923,12646235,15580519 secreted 93 1 cytoplasm. plasma membrane multiple Euteleostomi Bilateria Eumetazoa SPRED3 HGNC:31041 sprouty-related, EVH1 domain containing 3 Q2MJR0 Membrane; Peripheral membrane protein (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12646235,16478641 cytoplasm 12 1 cytoplasm. plasma membrane multiple Eutheria Eutheria Eumetazoa SPRN HGNC:16871 shadow of prion protein homolog (zebrafish) Q5BIV9 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Extracellular (GO:0005576) 14527721 mitochondrion membrane 13 1 secreted secreted Theria Theria Euarchontoglires SPRR1A HGNC:11259 small proline-rich protein 1A P35321 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9115270,11850458 cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Catarrhini Mammalia SPRR1B HGNC:11260 small proline-rich protein 1B P22528 Cytoplasm. Cytoplasm (GO:0005737) 9115270 cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Catarrhini Mammalia SPRR2A HGNC:11261 small proline-rich protein 2A P35326 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm NA NA NA SPRR2B HGNC:11262 small proline-rich protein 2B P35325 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Human Human NA SPRR2D HGNC:11264 small proline-rich protein 2D P22532 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Human Human NA SPRR2E HGNC:11265 small proline-rich protein 2E P22531 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Human Human NA SPRR2F HGNC:11266 small proline-rich protein 2F Q96RM1 Cytoplasm (By similarity). secreted 80 0 secreted secreted NA NA NA SPRR2G HGNC:11267 small proline-rich protein 2G Q9BYE4 Cytoplasm (By similarity). cytoplasm 39 0 cytoplasm cytoplasm Human Human NA SPRR3 HGNC:11268 small proline-rich protein 3 Q9UBC9 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12786819,18832573 cytoplasm 100 0 cytoplasm cytoplasm Human Tetrapoda Cell.Organisms SPRR4 HGNC:23173 small proline-rich protein 4 Q96PI1 Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes. cytoplasm 96 0 cytoplasm cytoplasm Catarrhini Euarchontoglires Boreoeutheria SPRTN HGNC:25356 SprT-like N-terminal domain Q9H040 Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled relication forks at sites of replication stress. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms SPRY1 HGNC:11269 sprouty homolog 1, antagonist of FGF signaling (Drosophila) O43609 Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10887178,12402043 secreted 97 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Eumetazoa SPRY2 HGNC:11270 sprouty homolog 2 (Drosophila) O43597 Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10887178,10887178 secreted 97 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Eumetazoa SPRY3 HGNC:11271 sprouty homolog 3 (Drosophila) O43610 Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12391162,10887178,12391162,10887178 plasma membrane 15 1 cytoplasm. plasma membrane multiple Amniota Euteleostomi Eumetazoa SPRY4 HGNC:15533 sprouty homolog 4 (Drosophila) Q9C004 Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm (GO:0005737) 12027893 secreted 96 1 cytoplasm cytoplasm Human Euteleostomi Eumetazoa SPRYD3 HGNC:25920 SPRY domain containing 3 Q8NCJ5 mitochondrion 14 0 mitochondrion mitochondrion Deuterostomia Deuterostomia Eukaryota SPRYD4 HGNC:27468 SPRY domain containing 4 Q8WW59 secreted 15 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa SPRYD7 HGNC:14297 SPRY domain containing 7 Q5W111 cytoplasm 20 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa SPSB1 HGNC:30628 splA/ryanodine receptor domain and SOCS box containing 1 Q96BD6 Cytoplasm (Probable). secreted 26 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SPSB2 HGNC:29522 splA/ryanodine receptor domain and SOCS box containing 2 Q99619 Cytoplasm (Probable). secreted 28 0 cytoplasm cytoplasm Eutheria Eutheria NA SPSB3 HGNC:30629 splA/ryanodine receptor domain and SOCS box containing 3 Q6PJ21 secreted 11 0 secreted secreted Tetrapoda Bilateria Cell.Organisms SPSB4 HGNC:30630 splA/ryanodine receptor domain and SOCS box containing 4 Q96A44 Cytoplasm (Probable). secreted 34 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SPTA1 HGNC:11272 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) P02549 Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12105217,15598749,17081983,17081983 cytoplasm 7 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota SPTAN1 HGNC:11273 spectrin, alpha, non-erythrocytic 1 Q13813 Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells (By similarity). Nucleus (GO:0005634);Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829); Nucleus (GO:0005634) ,12571280,/11856323,11856323,16263121,,12571280, cytoplasm 14 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms SPTB HGNC:11274 spectrin, beta, erythrocytic P11277 Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7962054,15598749/17081983,17081983 cytoplasm 31 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota SPTBN1 HGNC:11275 spectrin, beta, non-erythrocytic 1 Q01082 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, M line (By similarity). Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytoskeleton (GO:0005856); Nucleus (GO:0005634) 8688828,8688828,8688828,17000644 cytoplasm 27 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SPTBN2 HGNC:11276 spectrin, beta, non-erythrocytic 2 O15020 Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Cytoplasmic vesicle (GO:0016023) 9826670,9826670,9826670 cytoplasm 29 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Eukaryota SPTBN4 HGNC:14896 spectrin, beta, non-erythrocytic 4 Q9H254 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11294830,11294830 cytoplasm 26 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota SPTBN5 HGNC:15680 spectrin, beta, non-erythrocytic 5 Q9NRC6 Cytoplasm, cytoskeleton. Note=Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells. Cytoplasm (GO:0005737) 10764729 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SPTLC1 HGNC:11277 serine palmitoyltransferase, long chain base subunit 1 O15269 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 10722674,18484747 endoplasmic reticulum membrane 91 1 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Cell.Organisms SPTLC2 HGNC:11278 serine palmitoyltransferase, long chain base subunit 2 O15270 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10722674,15598749 endoplasmic reticulum membrane 96 1 endoplasmic reticulum. mitochondrion multiple Eukaryota Cell.Organisms Cell.Organisms SPTLC3 HGNC:16253 serine palmitoyltransferase, long chain base subunit 3 Q9NUV7 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). endoplasmic reticulum membrane 63 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms SPTSSA HGNC:20361 serine palmitoyltransferase, small subunit A Q969W0 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 31 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Opisthokonta SPTSSB HGNC:24045 serine palmitoyltransferase, small subunit B Q8NFR3 Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 42 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Opisthokonta Opisthokonta SPTY2D1 HGNC:26818 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) Q68D10 plasma membrane 24 0 n/a n/a Deuterostomia Deuterostomia Eumetazoa SPZ1 HGNC:30721 spermatogenic leucine zipper 1 Q9BXG8 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) 11165476 endoplasmic reticulum membrane 14 0 nucleus nucleus Eutheria Eutheria Euteleostomi SQLE HGNC:11279 squalene epoxidase Q14534 Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 1964954,2211682 plasma membrane 27 6 endoplasmic reticulum. endoplasmic reticulum membrane multiple Euteleostomi Cell.Organisms Cell.Organisms SQRDL HGNC:20390 sulfide quinone reductase-like (yeast) Q9Y6N5 Mitochondrion (Probable). Mitochondrion (GO:0005739) mitochondrion 28 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms SQSTM1 HGNC:11280 sequestosome 1 Q13501 Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Note=Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin- containing protein aggregates (sequestosomes) and membrane- surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in the cytoplasmic bodies. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endosome (GO:0005768);Nucleus (GO:0005634) 8650207,11852044,12813044,17081983,9566925/17081983 golgi apparatus 51 0 cytoplasm. endoplasmic reticulum. endosome. lysosome. nucleus multiple Deuterostomia Deuterostomia Eukaryota SRA1 HGNC:11281 steroid receptor RNA activator 1 Q9HD15 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12565891,12565891 nucleus 45 0 cytoplasm. nucleus multiple Theria Deuterostomia Opisthokonta SRBD1 HGNC:25521 S1 RNA binding domain 1 Q8N5C6 Cytoplasm (GO:0005737) 17081983 mitochondrion 20 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms SRC HGNC:11283 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog P12931 Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 1384654,8978822,17254967,15027889,15466214,8978822,9560226,8978822,14627343,17254967,7565761,15466214 plasma membrane 31 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms SRCAP HGNC:16974 Snf2-related CREBBP activator protein Q6ZRS2 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SRCIN1 HGNC:29506 SRC kinase signaling inhibitor 1 Q9C0H9 Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 14657239,10625663,14657239 cytoplasm 33 0 cytoplasm cytoplasm Euteleostomi Euteleostomi NA SRCRB4D HGNC:14461 scavenger receptor cysteine rich domain containing, group B (4 domains) Q8WTU2 Secreted (Potential). Extracellular (GO:0005576) 12466895 secreted 34 0 secreted secreted Human Eukaryota Eukaryota SRD5A1 HGNC:11284 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) P18405 Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 2339109,4400474 endoplasmic reticulum membrane 23 6 endoplasmic reticulum. nucleus multiple Chordata Cell.Organisms Cell.Organisms SRD5A2 HGNC:11285 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) P31213 Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 10342882 endoplasmic reticulum membrane 25 6 endoplasmic reticulum endoplasmic reticulum Chordata Cell.Organisms NA SRD5A3 HGNC:25812 steroid 5 alpha-reductase 3 Q9H8P0 Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable). endoplasmic reticulum membrane 77 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Cell.Organisms SREBF1 HGNC:11289 sterol regulatory element binding transcription factor 1 P36956 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Processed sterol regulatory element-binding protein 1: Nucleus. Isoform SREBP-1aDelta: Nucleus. Isoform SREBP-1cDelta: Nucleus. Nucleus (GO:0005634); Endoplasmic reticulum membrane (GO:0005789); Microsome (GO:0005792); Nuclear membrane (GO:0005635);Nucleus (GO:0005634) 8626610,8156598,8006035,7759101,8626610,11448953,8156598/17081983 nucleus 30 2 endoplasmic reticulum membrane. golgi apparatus membrane. nucleus. nucleus membrane multiple Bilateria Bilateria Eukaryota SREBF2 HGNC:11290 sterol regulatory element binding transcription factor 2 Q12772 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Processed sterol regulatory element-binding protein 2: Nucleus. Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 7759101,10896675,8626610 nucleus 22 2 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. nucleus multiple Bilateria Bilateria Opisthokonta SREK1 HGNC:17882 splicing regulatory glutamine/lysine-rich protein 1 Q8WXA9 Nucleus. Nucleus (GO:0005634) 10757789,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms SREK1IP1 HGNC:26716 SREK1-interacting protein 1 Q8N9Q2 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15456940,17081983 nucleus 100 0 cytoplasm. nucleus multiple Amniota Amniota Eukaryota SRF HGNC:11291 serum response factor (c-fos serum response element-binding transcription factor) P11831 Nucleus. Nucleus (GO:0005634) 11181183 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota SRFBP1 HGNC:26333 serum response factor binding protein 1 Q8NEF9 Cytoplasm, perinuclear region (By similarity). Nucleus (GO:0005634); Cytosol (GO:0005829); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737) 15492011,17081983,16647043,16647043,17081983 cytoplasm 59 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Opisthokonta SRGAP1 HGNC:17382 SLIT-ROBO Rho GTPase activating protein 1 Q7Z6B7 Cytoplasm (GO:0005737); Nucleus (GO:0005634) none,17081983,17081983 cytoplasm 37 2 nucleus nucleus Bilateria Bilateria Eukaryota SRGAP2 HGNC:19751 SLIT-ROBO Rho GTPase activating protein 2 O75044 Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome (By similarity). Nucleus (By similarity). Cytoplasm (By similarity). Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 37 2 cytoplasm. nucleus multiple Bilateria Bilateria NA SRGAP2C HGNC:30584 SLIT-ROBO Rho GTPase activating protein 2C P0DJJ0 cytoplasm 32 0 cytoplasm cytoplasm NA NA NA SRGAP3 HGNC:19744 SLIT-ROBO Rho GTPase activating protein 3 O43295 cytoplasm 40 2 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SRGN HGNC:9361 serglycin P10124 Cytoplasmic granule (By similarity). Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 3366780,11154222 secreted 92 0 cytoplasm. golgi apparatus. secreted multiple Amniota Amniota Euteleostomi SRI HGNC:11292 sorcin P30626 Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10748169,9668070,10748169,7835417 cytoplasm 19 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota SRL HGNC:11295 sarcalumenin Q86TD4 Sarcoplasmic reticulum lumen (By similarity). Note=Associated through calcium with the membrane (By similarity). Sarcoplasmic reticulum (GO:0016529) 2762314 endoplasmic reticulum 69 0 endoplasmic reticulum endoplasmic reticulum Theria Bilateria Cell.Organisms SRM HGNC:11296 spermidine synthase P19623 Cytoplasm (GO:0005737) cytoplasm 19 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms SRMS HGNC:11298 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Q9H3Y6 cytoplasm 100 0 cytoplasm cytoplasm Amniota Euteleostomi Cell.Organisms SRP14 HGNC:11299 signal recognition particle 14kDa (homologous Alu RNA binding protein) P37108 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Cytosol (GO:0005829) 2153922,11790298,15635413,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SRP19 HGNC:11300 signal recognition particle 19kDa P09132 Cytoplasm. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10618370,11682607,15635413,10618370,11682607,11682607 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SRP54 HGNC:11301 signal recognition particle 54kDa P61011 Nucleus speckle. Cytoplasm. Cytoplasm (GO:0005737) 10618370 cytoplasm 100 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms SRP68 HGNC:11302 signal recognition particle 68kDa Q9UHB9 Cytoplasm. Nucleus, nucleolus. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Cytosol (GO:0005829) 10618370,10618370,10618370,15561729 cytoplasm 9 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Eukaryota SRP72 HGNC:11303 signal recognition particle 72kDa O76094 Cytoplasm. Endoplasmic reticulum. Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 15635413,10618370,15561729 cytoplasm 22 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Cell.Organisms SRP9 HGNC:11304 signal recognition particle 9kDa P49458 Cytoplasm. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 7518078,15635413 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SRPK1 HGNC:11305 SRSF protein kinase 1 Q96SB4 Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Isoform 1: Cytoplasm. Nucleus matrix. Microsome. Note=Mainly localized in the microsomal fraction and the cytoplasm, and to a lesser extent in the nuclear matrix. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9472028,15034300,17081983,9472028,15034300,17081983 nucleus 34 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SRPK2 HGNC:11306 SRSF protein kinase 2 P78362 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9472028,9446799,9472028,10196197,17081983 nucleus 45 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SRPK3 HGNC:11402 SRSF protein kinase 3 Q9UPE1 nucleus 34 0 nucleus nucleus Eukaryota Eukaryota NA SRPR HGNC:11307 signal recognition particle receptor (docking protein) P08240 Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. Endoplasmic reticulum (GO:0005783) 2827661 mitochondrion 14 0 endoplasmic reticulum endoplasmic reticulum Cell.Organisms Cell.Organisms Cell.Organisms SRPRB HGNC:24085 signal recognition particle receptor, B subunit Q9Y5M8 Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12918107,7844142,15598749,15561729 cytoplasm 15 2 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota SRPX HGNC:11309 sushi-repeat containing protein, X-linked P78539 Cell surface (Probable). Note=Possibly surface of photoreceptor cell. Plasma membrane (GO:0005886) 8634708 secreted 20 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms SRPX2 HGNC:30668 sushi-repeat containing protein, X-linked 2 O60687 Cytoplasm. Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9864177,18718938,9864177 secreted 20 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Cell.Organisms SRR HGNC:14398 serine racemase Q9GZT4 Cytoplasm (GO:0005737) 12560076 mitochondrion 18 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms SRRD HGNC:33910 SRR1 domain containing Q9UH36 cytoplasm 11 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota SRRM1 HGNC:16638 serine/arginine repetitive matrix 1 Q8IYB3 Nucleus matrix. Nucleus speckle. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 12624182,17081983,17081983/17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SRRM2 HGNC:16639 serine/arginine repetitive matrix 2 Q9UQ35 Nucleus speckle. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10668804,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Human Eukaryota Eukaryota SRRM3 HGNC:26729 serine/arginine repetitive matrix 3 A6NNA2 Nucleus (GO:0005634) nucleus 22 0 nucleus nucleus Amniota Euteleostomi NA SRRM4 HGNC:29389 serine/arginine repetitive matrix 4 A7MD48 Nucleus (By similarity). nucleus 83 0 nucleus nucleus Tetrapoda Tetrapoda Euteleostomi SRRM5 HGNC:37248 serine/arginine repetitive matrix 5 B3KS81 nucleus 17 0 nucleus nucleus NA NA Cell.Organisms SRRT HGNC:24101 serrate RNA effector molecule homolog (Arabidopsis) Q9BXP5 Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 19 0 nucleus nucleus Theria Eukaryota Eukaryota SRSF1 HGNC:10780 serine/arginine-rich splicing factor 1 Q07955 Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10843177,10225947,16982639,17081983,10225947,17081983,11790298,15635413 nucleus 58 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SRSF10 HGNC:16713 serine/arginine-rich splicing factor 10 O75494 Nucleus speckle. Cytoplasm. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11790298,16135820,16135820,11684676,17081983,16135820,11684676,17081983,11684676/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms SRSF11 HGNC:10782 serine/arginine-rich splicing factor 11 Q05519 Nucleus. Note=Colocalizes with spliceosome components. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1896467,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota SRSF12 HGNC:21220 serine/arginine-rich splicing factor 12 Q8WXF0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Euarchontoglires Tetrapoda Cell.Organisms SRSF2 HGNC:10783 serine/arginine-rich splicing factor 2 Q01130 Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10082253,16982639,11790298 nucleus 100 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms SRSF3 HGNC:10785 serine/arginine-rich splicing factor 3 P84103 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9420331,17081983,9420331,17183366,17081983,11790298,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms SRSF4 HGNC:10786 serine/arginine-rich splicing factor 4 Q08170 Nucleus speckle. Nucleus (GO:0005634) 8321209,17081983 nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Cell.Organisms SRSF5 HGNC:10787 serine/arginine-rich splicing factor 5 Q13243 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12665590,9037021,11790298,15635413 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms SRSF6 HGNC:10788 serine/arginine-rich splicing factor 6 Q13247 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 7556075,17081983,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms SRSF7 HGNC:10789 serine/arginine-rich splicing factor 7 Q16629 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8013463,15652821,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms SRSF8 HGNC:16988 serine/arginine-rich splicing factor 8 Q9BRL6 Nucleus. Nucleus (GO:0005634) 9671500,17081983 nucleus 100 0 nucleus nucleus Bilateria Cell.Organisms NA SRSF9 HGNC:10791 serine/arginine-rich splicing factor 9 Q13242 Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10196175,12604611,11790298 nucleus 100 0 nucleus nucleus Theria Eukaryota Cell.Organisms SRXN1 HGNC:16132 sulfiredoxin 1 Q9BYN0 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Eukaryota NA SRY HGNC:11311 sex determining region Y Q05066 Nucleus speckle. Cytoplasm. Note=Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10235389,7876301,11641389,12764225,16166090,12764225 nucleus 96 0 cytoplasm. nucleus multiple Homininae Euarchontoglires Eukaryota SS18 HGNC:11340 synovial sarcoma translocation, chromosome 18 Q15532 Nucleus (Probable). Nucleus (GO:0005634) 9285794,10072425 nucleus 50 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SS18L1 HGNC:15592 synovial sarcoma translocation gene on chromosome 18-like 1 O75177 Nucleus (By similarity). Chromosome, centromere, kinetochore (By similarity). Note=Localizes to nuclear bodies. Co-localizes with SGOL1 at kinetochore (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15866867,14716005,15866867 nucleus 83 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota SS18L2 HGNC:15593 synovial sarcoma translocation gene on chromosome 18-like 2 Q9UHA2 nucleus 49 0 nucleus nucleus Human Human Eukaryota SSB HGNC:11316 Sjogren syndrome antigen B (autoantigen La) P05455 Nucleus (Probable). Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12102760,17081983,12102760,17081983 cytoplasm 22 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SSBP1 HGNC:11317 single-stranded DNA binding protein 1, mitochondrial Q04837 Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 8482537,9452467,15598749,2159011 mitochondrion 100 0 mitochondrion. nucleus multiple Euteleostomi Cell.Organisms NA SSBP2 HGNC:15831 single-stranded DNA binding protein 2 P81877 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 78 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SSBP3 HGNC:15674 single stranded DNA binding protein 3 Q9BWW4 Nucleus (By similarity). Nucleus (GO:0005634) 12381786 nucleus 98 0 nucleus nucleus Bilateria Bilateria Eukaryota SSBP4 HGNC:15676 single stranded DNA binding protein 4 Q9BWG4 Nucleus (By similarity). nucleus 70 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota SSC5D HGNC:26641 scavenger receptor cysteine rich domain containing (5 domains) A1L4H1 Secreted (By similarity). Cytoplasm (By similarity). secreted 33 0 secreted secreted Eutheria Mammalia Eukaryota SSFA2 HGNC:11319 sperm specific antigen 2 P28290 Cytoplasm. Note=Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1555770,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Craniata SSH1 HGNC:30579 slingshot protein phosphatase 1 Q8WYL5 Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis. Cytoplasm (GO:0005737); Actin filament (GO:0005884) 14531860,16513117,17350576 cytoplasm 57 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms SSH2 HGNC:30580 slingshot protein phosphatase 2 Q76I76 Cytoplasm, cytoskeleton. Nucleus (GO:0005634);Cytoplasm (GO:0005737) 17081983/14531860 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms SSH3 HGNC:30581 slingshot protein phosphatase 3 Q8TE77 Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14531860,14531860 cytoplasm 34 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Cell.Organisms SSMEM1 HGNC:29580 serine-rich single-pass membrane protein 1 Q8WWF3 Membrane; Single-pass membrane protein (Potential). nucleus 31 1 nucleus nucleus Mammalia Mammalia Mammalia SSNA1 HGNC:11321 Sjogren syndrome nuclear autoantigen 1 O43805 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus (GO:0005634) 9430706 nucleus 52 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota SSPN HGNC:11322 sarcospan Q14714 Cell membrane; Multi-pass membrane protein (By similarity). Cell membrane, sarcolemma (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions (By similarity). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 10651799,10651799 plasma membrane 43 4 golgi apparatus. plasma membrane multiple Euteleostomi Euteleostomi Bilateria SSPO HGNC:21998 SCO-spondin A2VEC9 Secreted, extracellular space (By similarity). secreted 75 0 secreted secreted Amniota Deuterostomia NA SSR1 HGNC:11323 signal sequence receptor, alpha P43307 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 1964414,17380188,15561729,17380188,15598749,17081983 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion. nucleus multiple Chordata Eukaryota Eukaryota SSR2 HGNC:11324 signal sequence receptor, beta (translocon-associated protein beta) P43308 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792) 8286409,7789174,17380188,17380188 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Eukaryota Eukaryota SSR3 HGNC:11325 signal sequence receptor, gamma (translocon-associated protein gamma) Q9UNL2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome (GO:0005792); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 7916687,17380188,7916687,17380188,15561729,15598749,17081983 endoplasmic reticulum membrane 100 4 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Bilateria Bilateria Eukaryota SSR4 HGNC:11326 signal sequence receptor, delta P51571 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Mitochondrion (GO:0005739) 7916687,17380188,17380188,15598749 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Bilateria Bilateria NA SSRP1 HGNC:11327 structure specific recognition protein 1 Q08945 Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694) 15034300,17081983,10912001,15034300,17081983,15635413,16902406 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SSSCA1 HGNC:11328 Sjogren syndrome/scleroderma autoantigen 1 O60232 Centrosome (GO:0005813) 9486406 nucleus 76 0 nucleus nucleus Theria Bilateria Eukaryota SST HGNC:11329 somatostatin P61278 Secreted. Extracellular (GO:0005576) 15472172,8612489,4682131 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Euteleostomi SSTR1 HGNC:11330 somatostatin receptor 1 P30872 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9279525 plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Metazoa SSTR2 HGNC:11331 somatostatin receptor 2 P30874 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9279525,16917505 plasma membrane 48 7 plasma membrane plasma membrane Bilateria Bilateria Metazoa SSTR3 HGNC:11332 somatostatin receptor 3 P32745 Cell membrane; Multi-pass membrane protein (By similarity). Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation (By similarity). Plasma membrane (GO:0005886) 1337145 plasma membrane 81 7 plasma membrane plasma membrane Euarchontoglires Euteleostomi Eumetazoa SSTR4 HGNC:11333 somatostatin receptor 4 P31391 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9279525 plasma membrane 100 7 plasma membrane plasma membrane Euarchontoglires Euteleostomi Metazoa SSTR5 HGNC:11334 somatostatin receptor 5 P35346 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9279525 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa SSU72 HGNC:25016 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) Q9NP77 Nucleus. Cytoplasm. Note=Predominantly in the cytosol. nucleus 35 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota SSUH2 HGNC:24809 ssu-2 homolog (C. elegans) Q9Y2M2 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms SSX1 HGNC:11335 synovial sarcoma, X breakpoint 1 Q16384 Nucleus (GO:0005634) 10072425 nucleus 73 0 nucleus nucleus Eutheria Eutheria NA SSX2 HGNC:11336 synovial sarcoma, X breakpoint 2 Q16385 Nucleus. Nucleus (GO:0005634) 12007189,12037676,9285793 nucleus 100 0 nucleus nucleus NA NA NA SSX2B HGNC:22263 synovial sarcoma, X breakpoint 2B Q16385 Nucleus. nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Eutheria SSX2IP HGNC:16509 synovial sarcoma, X breakpoint 2 interacting protein Q9Y2D8 Cell junction, adherens junction (By similarity). Nucleus. Note=Not found at cell-matrix AJs (By similarity). Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12007189,12446711 secreted 84 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota SSX3 HGNC:11337 synovial sarcoma, X breakpoint 3 Q99909 Nucleus (GO:0005634) 12007189 nucleus 89 0 nucleus nucleus Catarrhini Catarrhini NA SSX4 HGNC:11338 synovial sarcoma, X breakpoint 4 O60224 Nucleus (GO:0005634) 11107170,12007189 nucleus 75 0 nucleus nucleus Catarrhini Catarrhini Eutheria SSX4B HGNC:16880 synovial sarcoma, X breakpoint 4B O60224 Nucleus (GO:0005634) nucleus 75 0 nucleus nucleus Catarrhini Catarrhini Eutheria SSX5 HGNC:11339 synovial sarcoma, X breakpoint 5 O60225 Nucleus (GO:0005634) 11107170,12007189 nucleus 80 0 nucleus nucleus Human Euarchontoglires NA SSX7 HGNC:19653 synovial sarcoma, X breakpoint 7 Q7RTT5 Nucleus (GO:0005634) nucleus 82 0 nucleus nucleus Catarrhini Catarrhini NA SSX8 HGNC:19654 synovial sarcoma, X breakpoint 8 Q7RTT4 Nucleus (GO:0005634) nucleus 74 0 nucleus nucleus Euarchontoglires Euarchontoglires NA ST13 HGNC:11343 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) P50502 Cytoplasm (By similarity). Lysosome (GO:0005764); Cytoplasm (GO:0005737) 11559757,8721986,17081983 cytoplasm 90 0 cytoplasm. lysosome multiple Bilateria Eukaryota Cell.Organisms ST14 HGNC:11344 suppression of tumorigenicity 14 (colon carcinoma) Q9Y5Y6 Membrane; Single-pass type II membrane protein (Probable). Plasma membrane (GO:0005886) 10831593 plasma membrane 34 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms ST18 HGNC:18695 suppression of tumorigenicity 18, zinc finger O60284 Nucleus. Nucleus (GO:0005634) 15489893 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Metazoa ST20 HGNC:33520 suppressor of tumorigenicity 20 Q9HBF5 cytoplasm 96 0 cytoplasm cytoplasm Homininae Homininae Eutheria ST3GAL1 HGNC:10862 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Q11201 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. Golgi membrane (GO:0000139) 11690653 golgi apparatus membrane 19 0 golgi apparatus membrane. secreted multiple Euteleostomi Eukaryota Eukaryota ST3GAL2 HGNC:10863 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Q16842 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Secreted (By similarity). Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 15 1 golgi apparatus membrane golgi apparatus membrane Deuterostomia Deuterostomia Eukaryota ST3GAL3 HGNC:10866 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Q11203 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Apical membrane (GO:0016327) 9451034,9451034,9451034 golgi apparatus membrane 10 1 golgi apparatus. golgi apparatus membrane. plasma membrane. secreted multiple Euteleostomi Deuterostomia Eukaryota ST3GAL4 HGNC:10864 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Q11206 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. Golgi apparatus (GO:0005794); Integral to membrane (GO:0016021); Extracellular (GO:0005576) 7588599,7901202,7901202 golgi apparatus membrane 15 1 golgi apparatus. golgi apparatus membrane. secreted multiple Euteleostomi Euteleostomi Eukaryota ST3GAL5 HGNC:10872 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Q9UNP4 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) 11030748 golgi apparatus membrane 12 1 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Eukaryota ST3GAL6 HGNC:18080 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Q9Y274 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) golgi apparatus membrane 21 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Tetrapoda Bilateria ST5 HGNC:11350 suppression of tumorigenicity 5 P78524 cytoplasm 42 3 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota ST6GAL1 HGNC:10860 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 P15907 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cell surface (GO:0009986) 7615680,11356854,8995311,8995311,2373995,2373995 golgi apparatus membrane 10 0 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. secreted multiple Euteleostomi Euteleostomi Eukaryota ST6GAL2 HGNC:10861 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 Q96JF0 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 12603328 golgi apparatus membrane 14 1 golgi apparatus golgi apparatus Euteleostomi Bilateria Eukaryota ST6GALNAC1 HGNC:23614 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Q9NSC7 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 12770770,17081983 golgi apparatus membrane 22 0 golgi apparatus. nucleus multiple Amniota Deuterostomia Eukaryota ST6GALNAC2 HGNC:10867 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Q9UJ37 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) golgi apparatus membrane 20 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Eukaryota ST6GALNAC3 HGNC:19343 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 Q8NDV1 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). golgi apparatus membrane 29 0 golgi apparatus membrane golgi apparatus membrane Euarchontoglires Euteleostomi Eukaryota ST6GALNAC4 HGNC:17846 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Q9H4F1 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11062056,17081983,17081983 golgi apparatus membrane 33 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota ST6GALNAC5 HGNC:19342 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Q9BVH7 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 89 0 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Eukaryota ST6GALNAC6 HGNC:23364 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Q969X2 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Integral to membrane (GO:0016021) 10702226 golgi apparatus membrane 42 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eukaryota ST7 HGNC:11351 suppression of tumorigenicity 7 Q9NRC1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 13 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Cell.Organisms ST7L HGNC:18441 suppression of tumorigenicity 7 like Q8TDW4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 15 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Cell.Organisms ST8SIA1 HGNC:10869 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Q92185 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 9287216,8058740 golgi apparatus membrane 61 0 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Eukaryota ST8SIA2 HGNC:10870 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Q92186 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Extracellular (GO:0005576) 11744634,9852130,7588599,11744634,9852130,11744634,9852130 golgi apparatus membrane 25 0 golgi apparatus. secreted multiple Euteleostomi Euteleostomi Eukaryota ST8SIA3 HGNC:14269 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 O43173 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) 10766765 golgi apparatus membrane 24 0 golgi apparatus golgi apparatus Euteleostomi Deuterostomia Eukaryota ST8SIA4 HGNC:10871 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Q92187 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10660622,9852130,10660622,9852130,10660622,9852130 golgi apparatus membrane 19 0 golgi apparatus. secreted multiple Tetrapoda Euteleostomi Eukaryota ST8SIA5 HGNC:17827 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 O15466 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) golgi apparatus membrane 35 2 golgi apparatus membrane golgi apparatus membrane Amniota Euteleostomi Eukaryota ST8SIA6 HGNC:23317 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 P61647 Golgi apparatus membrane; Single-pass type II membrane protein (Potential). Golgi apparatus (GO:0005794) golgi apparatus membrane 29 0 golgi apparatus membrane golgi apparatus membrane Tetrapoda Euteleostomi Eukaryota STAB1 HGNC:18628 stabilin 1 Q9NY15 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Endosome (GO:0005768); Cytoplasm (GO:0005737) 11829752,12473645,11829752 secreted 30 1 cytoplasm. endosome. plasma membrane multiple Euteleostomi Deuterostomia Cell.Organisms STAB2 HGNC:18629 stabilin 2 Q8WWQ8 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface. Plasma membrane (GO:0005886) 11829752 plasma membrane 23 1 cytoplasm. plasma membrane multiple Euteleostomi Deuterostomia Cell.Organisms STAC HGNC:11353 SH3 and cysteine rich domain Q99469 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota STAC2 HGNC:23990 SH3 and cysteine rich domain 2 Q6ZMT1 cytoplasm 38 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota STAC3 HGNC:28423 SH3 and cysteine rich domain 3 Q96MF2 cytoplasm 31 0 cytoplasm cytoplasm Eutheria Chordata Eukaryota STAG1 HGNC:11354 stromal antigen 1 Q8WVM7 Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Nucleus (GO:0005634) 9305759,11076961 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota STAG2 HGNC:11355 stromal antigen 2 Q8N3U4 Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. Nucleus (GO:0005634); Chromosome (GO:0005694); Cytoplasm (GO:0005737) 11590136,17081983,17113138,17113138 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota STAG3 HGNC:11356 stromal antigen 3 Q9UJ98 Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation. Cytoplasm (GO:0005737) 10698974 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota STAM HGNC:11357 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Q92783 Cytoplasm (Probable). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Cytoplasm (GO:0005737); Endosome (GO:0005768); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 11687594,12551915,12745081,12745081 cytoplasm 43 0 cytoplasm. endosome. mitochondrion. nucleus multiple Bilateria Opisthokonta NA STAM2 HGNC:11358 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 O75886 Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737) 11687594,17081983 cytoplasm 28 0 cytoplasm cytoplasm Euteleostomi Opisthokonta Eukaryota STAMBP HGNC:16950 STAM binding protein O95630 Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11483516,15314065,15314065 cytoplasm 18 0 cytoplasm. endosome. nucleus multiple Euteleostomi Eukaryota Eukaryota STAMBPL1 HGNC:24105 STAM binding protein-like 1 Q96FJ0 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12810066,12810066 nucleus 7 0 cytoplasm. nucleus multiple Mammalia Eukaryota Eukaryota STAP1 HGNC:24133 signal transducing adaptor family member 1 Q9ULZ2 Nucleus. Cytoplasm. Mitochondrion. cytoplasm 24 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Deuterostomia Chordata STAP2 HGNC:30430 signal transducing adaptor family member 2 Q9UGK3 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12540842,12540842,12540842 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Opisthokonta STAR HGNC:11359 steroidogenic acute regulatory protein P49675 Mitochondrion. Mitochondrion (GO:0005739) 7761400 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Bilateria Eukaryota STARD10 HGNC:10666 StAR-related lipid transfer (START) domain containing 10 Q9Y365 Cell projection, cilium, flagellum (By similarity). Cytoplasm. Membrane. Note=In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic. mitochondrion 11 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms STARD13 HGNC:19164 StAR-related lipid transfer (START) domain containing 13 Q9Y3M8 Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. Nucleus (GO:0005634) secreted 50 0 cytoplasm. lipid droplet multiple Chordata Bilateria Eukaryota STARD3 HGNC:17579 StAR-related lipid transfer (START) domain containing 3 Q14849 Late endosome membrane; Multi-pass membrane protein. Endosome (GO:0005768); Cytoplasm (GO:0005737) 11053434,12393907,9139840 mitochondrion 23 4 cytoplasm. endosome. endosome membrane multiple Bilateria Bilateria Holozoa STARD3NL HGNC:19169 STARD3 N-terminal like O95772 Late endosome membrane; Multi-pass membrane protein. Endosome (GO:0005768); Cytoplasm (GO:0005737) 12393907,17081983 plasma membrane 35 4 cytoplasm. endosome. endosome membrane multiple Tetrapoda Euteleostomi Holozoa STARD4 HGNC:18058 StAR-related lipid transfer (START) domain containing 4 Q96DR4 Plasma membrane (GO:0005886) 12011452 mitochondrion 6 0 mitochondrion mitochondrion Tetrapoda Eukaryota Eukaryota STARD5 HGNC:18065 StAR-related lipid transfer (START) domain containing 5 Q9NSY2 Cytoplasm (GO:0005737) 15897605 mitochondrion 10 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota STARD6 HGNC:18066 StAR-related lipid transfer (START) domain containing 6 P59095 Cytoplasm (GO:0005737) 12011452 cytoplasm 10 0 cytoplasm cytoplasm Mammalia Eukaryota Opisthokonta STARD7 HGNC:18063 StAR-related lipid transfer (START) domain containing 7 Q9NQZ5 Mitochondrion (Potential). cytoplasm 17 0 cytoplasm cytoplasm Bilateria Opisthokonta Eukaryota STARD8 HGNC:19161 StAR-related lipid transfer (START) domain containing 8 Q92502 Cell junction, focal adhesion. secreted 100 0 secreted secreted Chordata Bilateria Eukaryota STARD9 HGNC:19162 StAR-related lipid transfer (START) domain containing 9 Q9P2P6 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis. cytoplasm 26 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota STAT1 HGNC:11362 signal transducer and activator of transcription 1, 91kDa P42224 Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12039028,1496401,15123634,15210729,12923054,9135145,1496401,15123634,15210729,15010467,14623896,12923054,9630226 nucleus 14 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota STAT2 HGNC:11363 signal transducer and activator of transcription 2, 113kDa P52630 Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12039028,12039028 nucleus 16 0 cytoplasm. nucleus multiple Eutheria Tetrapoda Eukaryota STAT3 HGNC:11364 signal transducer and activator of transcription 3 (acute-phase response factor) P40763 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. Extracellular matrix (GO:0005578);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cell surface (GO:0009986) 15037656/12039028,15145953,15143062,14701810,12060494,10464281,11815625,9211920,12628925,16331268,12039028,15145953,15143062,15141228,14701810,12623850,9211920,7624343,15037656,12628925,16331268,12867595,12389630,15037656 nucleus 19 0 cytoplasm. mitochondrion. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota STAT4 HGNC:11365 signal transducer and activator of transcription 4 Q14765 Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12039028,12039028,9630226 nucleus 14 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota STAT5A HGNC:11366 signal transducer and activator of transcription 5A P42229 Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12039028,17081983,12039028,17081983 nucleus 7 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota STAT5B HGNC:11367 signal transducer and activator of transcription 5B P51692 Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12039028,12039028 nucleus 7 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota STAT6 HGNC:11368 signal transducer and activator of transcription 6, interleukin-4 induced P42226 Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12039028,12039028 nucleus 14 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota STATH HGNC:11369 statherin P02808 Secreted. Extracellular (GO:0005576); Nucleus (GO:0005634); Nucleus (GO:0005634) 12444093,9048421,15561729,17081983 secreted 100 0 nucleus. secreted multiple Homininae Homininae Primates STAU1 HGNC:11370 staufen double-stranded RNA binding protein 1 O95793 Cytoplasm. Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER). Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10022909,10022908,12065664,10325410 cytoplasm 18 0 cytoplasm. endoplasmic reticulum. nucleus multiple Human Bilateria Eumetazoa STAU2 HGNC:11371 staufen double-stranded RNA binding protein 2 Q9NUL3 Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1- dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). Ribosome (GO:0005840); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12140260,12140260,15561729 cytoplasm 22 0 cytoplasm. endoplasmic reticulum. nucleus multiple Euteleostomi Bilateria Eumetazoa STBD1 HGNC:24854 starch binding domain 1 O95210 Membrane; Single-pass type III membrane protein (Probable). Note=Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum. Sarcoplasmic reticulum (GO:0016529); Plasma membrane (GO:0005886) 9794794,9794794 mitochondrion 20 0 endoplasmic reticulum endoplasmic reticulum Theria Amniota NA STC1 HGNC:11373 stanniocalcin 1 P52823 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10947959,14500721,10725397,10725397 secreted 100 0 cytoplasm. nucleus. secreted multiple Chordata Chordata Chordata STC2 HGNC:11374 stanniocalcin 2 O76061 Secreted (Potential). Extracellular (GO:0005576) 9753616 secreted 21 0 secreted secreted Euteleostomi Euteleostomi Chordata STEAP1 HGNC:11378 six transmembrane epithelial antigen of the prostate 1 Q9UHE8 Endosome membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 61 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Amniota Holozoa STEAP1B HGNC:41907 STEAP family member 1B Q6NZ63 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 60 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Homininae Holozoa STEAP2 HGNC:17885 STEAP family member 2, metalloreductase Q8NFT2 Endosome membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Endosome (GO:0005768); Plasma membrane (GO:0005886) 12095985,12429817,12429817 endoplasmic reticulum membrane 35 6 endosome. golgi apparatus. plasma membrane multiple Tetrapoda Cell.Organisms Cell.Organisms STEAP3 HGNC:24592 STEAP family member 3, metalloreductase Q658P3 Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Nucleus (GO:0005634) endoplasmic reticulum membrane 40 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Cell.Organisms Cell.Organisms STEAP4 HGNC:21923 STEAP family member 4 Q687X5 Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11443137 endoplasmic reticulum membrane 41 6 golgi apparatus membrane. plasma membrane multiple Euteleostomi Cell.Organisms Cell.Organisms STH HGNC:18839 saitohin Q8IWL8 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 12032355 secreted 66 0 cytoplasm. nucleus multiple NA NA Primates STIL HGNC:10879 SCL/TAL1 interrupting locus Q15468 Cytoplasm, cytosol (By similarity). Cytoplasm (GO:0005737) 11668681,9372240 nucleus 78 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Eukaryota STIM1 HGNC:11386 stromal interaction molecule 1 Q13586 Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11004585,8921403,11463338,11983428,17081983,17081983 endoplasmic reticulum membrane 54 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus. plasma membrane multiple Bilateria Bilateria Holozoa STIM2 HGNC:19205 stromal interaction molecule 2 Q9P246 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11463338,17081983 endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane. nucleus. plasma membrane multiple Amniota Euteleostomi Holozoa STIP1 HGNC:11387 stress-induced phosphoprotein 1 P31948 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 1569099,17081983,1569099,14754904,17081983 cytoplasm 46 0 cytoplasm. golgi apparatus. nucleus multiple Eukaryota Eukaryota Cell.Organisms STK10 HGNC:11388 serine/threonine kinase 10 O94804 Cell membrane; Peripheral membrane protein. cytoplasm 35 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms STK11 HGNC:11389 serine/threonine kinase 11 Q15831 Nucleus. Cytoplasm. Membrane (By similarity). Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to mitochondrion during apoptosis. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Membrane fraction (GO:0005624) 11430832,11430832,11430832,11297520 cytoplasm 15 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms STK11IP HGNC:19184 serine/threonine kinase 11 interacting protein Q8N1F8 Cytoplasm. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11741830,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota STK16 HGNC:11394 serine/threonine kinase 16 O75716 Cytoplasm, perinuclear region. Membrane; Lipid-anchor (By similarity). Note=Associates with Golgi and Golgi-derived vesicles (By similarity). Golgi apparatus (GO:0005794) 9712705 cytoplasm 11 0 cytoplasm. golgi apparatus multiple Opisthokonta Eukaryota Cell.Organisms STK17A HGNC:11395 serine/threonine kinase 17a Q9UEE5 Nucleus. Nucleus (GO:0005634) 9786912 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms STK17B HGNC:11396 serine/threonine kinase 17b O94768 Nucleus. Cell membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Note=Colocalizes with STK17B at the plasma membrane (By similarity). Nucleus (GO:0005634) 9786912 nucleus 45 0 nucleus nucleus Theria Euteleostomi Cell.Organisms STK19 HGNC:11398 serine/threonine kinase 19 P49842 Nucleus. Nucleus (GO:0005634) 9812991 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota NA STK24 HGNC:11403 serine/threonine kinase 24 Q9Y6E0 Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleus (GO:0005634) 9353338,15037601,12107159/17081983 cytoplasm 36 0 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms STK25 HGNC:11404 serine/threonine kinase 25 O00506 Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus. Golgi apparatus (GO:0005794); Cytosol (GO:0005829) 15037601,15037601 cytoplasm 37 0 cytoplasm. golgi apparatus multiple Opisthokonta Cell.Organisms Cell.Organisms STK3 HGNC:11406 serine/threonine kinase 3 Q13188 Cytoplasm (By similarity). Nucleus (By similarity). Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) ,17081983 cytoplasm 37 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms STK31 HGNC:11407 serine/threonine kinase 31 Q9BXU1 cytoplasm 26 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms STK32A HGNC:28317 serine/threonine kinase 32A Q8WU08 nucleus 17 0 nucleus nucleus Bilateria Bilateria Cell.Organisms STK32B HGNC:14217 serine/threonine kinase 32B Q9NY57 Nucleus (GO:0005634) nucleus 15 0 nucleus nucleus Bilateria Bilateria Cell.Organisms STK32C HGNC:21332 serine/threonine kinase 32C Q86UX6 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms STK33 HGNC:14568 serine/threonine kinase 33 Q9BYT3 Cytoplasm, perinuclear region (By similarity). Nucleus (GO:0005634) 11738831 cytoplasm 63 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms STK35 HGNC:16254 serine/threonine kinase 35 Q8TDR2 Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11973348,11973348 nucleus 59 0 cytoplasm. nucleus multiple Chordata Chordata Cell.Organisms STK36 HGNC:17209 serine/threonine kinase 36 Q9NRP7 Cytoplasm. Nucleus. Note=Low levels also present in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10806483,10806483 cytoplasm 19 3 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms STK38 HGNC:17847 serine/threonine kinase 38 Q15208 Nucleus. Cytoplasm. Nucleus (GO:0005634) 7761441 cytoplasm 37 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms STK38L HGNC:17848 serine/threonine kinase 38 like Q9Y2H1 Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co- localizes with STK24/MST3 in the membrane. cytoplasm 38 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms STK39 HGNC:17717 serine threonine kinase 39 Q9UEW8 Cytoplasm (Probable). Nucleus (Probable). Note=Nucleus when caspase-cleaved (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10980603,17081983,10980603 cytoplasm 72 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms STK4 HGNC:11408 serine/threonine kinase 4 Q13043 Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829); Perinuclear region (GO:0048471) 12384512,11278283,12384512,11278283,11517310,16892067,16892067,16892067 cytoplasm 37 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms STK40 HGNC:21373 serine/threonine kinase 40 Q8N2I9 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 13679039,13679039 nucleus 10 1 cytoplasm. nucleus multiple Euteleostomi Bilateria Cell.Organisms STMN1 HGNC:6510 stathmin 1 P16949 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 11572331,15659612 cytoplasm 100 0 cytoplasm cytoplasm Amniota Deuterostomia Bilateria STMN2 HGNC:10577 stathmin 2 Q93045 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon. Golgi apparatus. Endosome (By similarity). Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms (By similarity). Golgi apparatus (GO:0005794) 10947801,9030585 cytoplasm 67 0 golgi apparatus golgi apparatus Amniota Euteleostomi Holozoa STMN3 HGNC:15926 stathmin-like 3 Q9NZ72 Golgi apparatus. Cell projection, growth cone. Cell projection, axon. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9788875,9788875,9603203 cytoplasm 61 0 cytoplasm. golgi apparatus multiple NA NA Holozoa STMN4 HGNC:16078 stathmin-like 4 Q9H169 Golgi apparatus (By similarity). Cell projection, growth cone (By similarity). Cell projection, axon (By similarity). Golgi apparatus (GO:0005794) 9788875 cytoplasm 66 0 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Eukaryota STMND1 HGNC:44668 stathmin domain containing 1 H3BQB6 nucleus 70 0 nucleus nucleus NA NA Tetrapoda STOM HGNC:3383 stomatin P27105 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Nucleus (GO:0005634) 12130500,9147127,12130500,9147127,12130500,17000644 plasma membrane 64 1 cytoplasm. melanosome. nucleus. plasma membrane multiple Bilateria Cell.Organisms Cell.Organisms STOML1 HGNC:14560 stomatin (EPB72)-like 1 Q9UBI4 Membrane; Single-pass type III membrane protein (Potential). Plasma membrane (GO:0005886) 9931417 plasma membrane 26 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms STOML2 HGNC:14559 stomatin (EPB72)-like 2 Q9UJZ1 Mitochondrion inner membrane. Mitochondrion intermembrane space. Cell membrane; Peripheral membrane protein. Membrane raft; Peripheral membrane protein. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Integral to membrane (GO:0016021) 10713127,15598749,15561729 mitochondrion 46 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms STOML3 HGNC:19420 stomatin (EPB72)-like 3 Q8TAV4 Cell membrane; Single-pass type III membrane protein (By similarity). Note=Detected in lipid rafts (By similarity). Plasma membrane (GO:0005886) plasma membrane 90 2 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms STON1 HGNC:17003 stonin 1 Q9Y6Q2 Cytoplasm. Membrane. Note=Some fraction is membrane-associated. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11381094,11381094 nucleus 62 0 cytoplasm cytoplasm NA NA Eukaryota STON2 HGNC:30652 stonin 2 Q8WXE9 Cytoplasm. Membrane. Note=Some fraction is membrane-associated. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11381094,14726597 nucleus 64 1 cytoplasm. plasma membrane multiple Bilateria Bilateria Eukaryota STOX1 HGNC:23508 storkhead box 1 Q6ZVD7 Isoform A: Cytoplasm. Nucleus. Isoform B: Nucleus. Isoform C: Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15806103,15806103 nucleus 89 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa STOX2 HGNC:25450 storkhead box 2 Q9P2F5 nucleus 93 0 nucleus nucleus Tetrapoda Euteleostomi Bilateria STPG1 HGNC:28070 sperm-tail PG-rich repeat containing 1 Q5TH74 Cytoplasm (By similarity). Nucleus (By similarity). secreted 60 0 secreted secreted Mammalia Eukaryota Eukaryota STPG2 HGNC:28712 sperm-tail PG-rich repeat containing 2 Q8N412 secreted 70 0 secreted secreted Mammalia Eukaryota Eukaryota STRA13 HGNC:11422 stimulated by retinoic acid 13 A8MT69 Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Nucleus (GO:0005634) 17347673 nucleus 100 0 nucleus nucleus Euarchontoglires Eukaryota Eukaryota STRA6 HGNC:30650 stimulated by retinoic acid 6 Q9BX79 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 76 11 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa STRA8 HGNC:30653 stimulated by retinoic acid 8 Q7Z7C7 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12489526 cytoplasm 60 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Chordata STRADA HGNC:30172 STE20-related kinase adaptor alpha Q7RTN6 Nucleus. Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12805220,12805220 cytoplasm 17 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms STRADB HGNC:13205 STE20-related kinase adaptor beta Q9C0K7 Nucleus. Cytoplasm. Cytoplasm (GO:0005737) cytoplasm 18 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms STRAP HGNC:30796 serine/threonine kinase receptor associated protein Q9Y3F4 Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10646843,15848170,15848170 cytoplasm 11 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms STRBP HGNC:16462 spermatid perinuclear RNA binding protein Q96SI9 Cytoplasm (By similarity). Note=Microtubule- associated that localizes to the manchette in developing spermatids (By similarity). Nucleus (GO:0005634) none,19059367 cytoplasm 99 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa STRC HGNC:16035 stereocilin Q7RTU9 Cell surface (By similarity). Cell projection, kinocilium (By similarity). Cell projection, stereocilium (By similarity). secreted 94 0 secreted secreted NA NA Eumetazoa STRIP1 HGNC:25916 striatin interacting protein 1 Q5VSL9 Cytoplasm. Note=Enriched on the plasma membrane. cytoplasm 100 3 cytoplasm cytoplasm Bilateria Bilateria Eukaryota STRIP2 HGNC:22209 striatin interacting protein 2 Q9ULQ0 Cytoplasm. Note=Enriched in lamellipodia. cytoplasm 100 3 cytoplasm cytoplasm Bilateria Bilateria Eukaryota STRN HGNC:11424 striatin, calmodulin binding protein O43815 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell projection, dendritic spine (By similarity). Note=CTTNBP2-binding may regulate dendritic spine distribution (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 8769426,8769426 nucleus 8 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms STRN3 HGNC:15720 striatin, calmodulin binding protein 3 Q13033 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 10681496,7910562,10748158,10748158 cytoplasm 11 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms STRN4 HGNC:15721 striatin, calmodulin binding protein 4 Q9NRL3 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell projection, dendritic spine (By similarity). Note=CTTNBP2-binding may regulate dendritic spine distribution (By similarity). Cytoplasm (GO:0005737) 10748158,17081983 cytoplasm 12 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms STS HGNC:11425 steroid sulfatase (microsomal), isozyme S P08842 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 3464600 endoplasmic reticulum membrane 100 2 endoplasmic reticulum. endoplasmic reticulum membrane multiple Tetrapoda Cell.Organisms Cell.Organisms STT3A HGNC:6172 STT3A, subunit of the oligosaccharyltransferase complex (catalytic) P46977 Endoplasmic reticulum membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8838310 endoplasmic reticulum membrane 100 13 endoplasmic reticulum membrane. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms STT3B HGNC:30611 STT3B, subunit of the oligosaccharyltransferase complex (catalytic) Q8TCJ2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,15598749,17081983,17081983 endoplasmic reticulum membrane 100 13 endoplasmic reticulum membrane. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms STUB1 HGNC:11427 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Q9UNE7 Cytoplasm. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) ,10330192,15107424,17081983,17873020,,12150907,17081983 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Cell.Organisms STX10 HGNC:11428 syntaxin 10 O60499 Golgi apparatus membrane; Single-pass type IV membrane protein (Potential). Golgi apparatus (GO:0005794) 9446797 golgi apparatus membrane 88 1 golgi apparatus golgi apparatus Catarrhini Eukaryota Eukaryota STX11 HGNC:11429 syntaxin 11 O75558 Membrane; Peripheral membrane protein (Potential). Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Integral to membrane (GO:0016021); Endosome (GO:0005768); Golgi apparatus (GO:0005794) 9571206,9553086,10036234,10036234,10036234,10036234 nucleus 18 1 cytoplasm. endosome. golgi apparatus. nucleus multiple Euteleostomi Eukaryota Eukaryota STX12 HGNC:11430 syntaxin 12 Q86Y82 Endosome membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side (Potential). Endosome (GO:0005768); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 9507000,9817754,10886332,17081983 golgi apparatus membrane 17 1 endosome. nucleus. plasma membrane multiple Deuterostomia Eukaryota Eukaryota STX16 HGNC:11431 syntaxin 16 O14662 Golgi apparatus membrane; Single-pass type IV membrane protein. Isoform C: Cytoplasm. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 9587053,9464276,9587053,9464276 golgi apparatus membrane 21 1 cytoplasm. endoplasmic reticulum. golgi apparatus. golgi apparatus membrane multiple Euteleostomi Eukaryota Eukaryota STX17 HGNC:11432 syntaxin 17 P56962 Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi- pass membrane protein (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein (By similarity). Cytoplasm, cytosol (By similarity). Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 9852078,10930465,10930465 mitochondrion membrane 37 2 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Deuterostomia Bilateria Metazoa STX18 HGNC:15942 syntaxin 18 Q9P2W9 Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Probable). Golgi apparatus membrane; Single-pass type IV membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 10788491,10788491 endoplasmic reticulum membrane 6 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota STX19 HGNC:19300 syntaxin 19 Q8N4C7 Membrane; Peripheral membrane protein (Potential). endoplasmic reticulum 12 1 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Eukaryota STX1A HGNC:11433 syntaxin 1A (brain) Q16623 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Isoform 2: Secreted (Probable). Plasma membrane (GO:0005886) 1321498,10080545,17363971 endoplasmic reticulum 10 1 plasma membrane. secreted multiple Eukaryota Eukaryota NA STX1B HGNC:18539 syntaxin 1B P61266 Membrane; Single-pass type IV membrane protein (Potential). Integral to membrane (GO:0016021);Plasma membrane (GO:0005886) /12093152 endoplasmic reticulum 10 1 plasma membrane plasma membrane Eukaryota Eukaryota Eukaryota STX2 HGNC:3403 syntaxin 2 P32856 Membrane; Single-pass type IV membrane protein. Plasma membrane (GO:0005886) 1581962 endoplasmic reticulum 9 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota STX3 HGNC:11438 syntaxin 3 Q13277 Membrane; Single-pass type IV membrane protein (Potential). Plasma membrane (GO:0005886) 10788461,12198139,9614185 endoplasmic reticulum 10 1 plasma membrane plasma membrane Euteleostomi Eukaryota Eukaryota STX4 HGNC:11439 syntaxin 4 Q12846 Cell membrane; Single-pass type IV membrane protein (Potential). Plasma membrane (GO:0005886) 18793635 golgi apparatus membrane 10 1 plasma membrane plasma membrane Mammalia Euteleostomi Eukaryota STX5 HGNC:11440 syntaxin 5 Q13190 Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12473691,9714710 golgi apparatus membrane 48 1 endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota STX6 HGNC:11441 syntaxin 6 O43752 Golgi apparatus membrane; Single-pass type IV membrane protein (Potential). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 11001914,8663448 vacuole 13 1 golgi apparatus. plasma membrane multiple Eukaryota Eukaryota Eukaryota STX7 HGNC:11442 syntaxin 7 O15400 Early endosome membrane; Single-pass type IV membrane protein (By similarity). Cytoplasm (GO:0005737); Endosome (GO:0005768); Lysosome (GO:0005764); Extracellular (GO:0005576) 12218144,10982406,10982406,12543931 endoplasmic reticulum 15 1 cytoplasm. endosome. lysosome. secreted multiple Euteleostomi Eukaryota Eukaryota STX8 HGNC:11443 syntaxin 8 Q9UNK0 Membrane; Single-pass type IV membrane protein (By similarity). Note=Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By similarity). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Endosome (GO:0005768); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 9852078,10198254,10839363,11786915,10683148,10564279,10564279,10564279 vacuole 14 1 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. plasma membrane multiple Euteleostomi Eukaryota Eukaryota STXBP1 HGNC:11444 syntaxin binding protein 1 P61764 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleolus (GO:0005730); Cytosol (GO:0005829) 8108429,8108429,15635413,17363971 cytoplasm 9 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota STXBP2 HGNC:11445 syntaxin binding protein 2 Q15833 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Secretory granule (GO:0030141) 12773094,12773094,12482918 cytoplasm 8 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota STXBP3 HGNC:11446 syntaxin binding protein 3 O00186 Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane- associated. Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737) 8824310,10194441,10194441 cytoplasm 6 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota STXBP4 HGNC:19694 syntaxin binding protein 4 Q6ZWJ1 Cytoplasm (By similarity). cytoplasm 72 0 cytoplasm cytoplasm Chordata Chordata Opisthokonta STXBP5 HGNC:19665 syntaxin binding protein 5 (tomosyn) Q5T5C0 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse (By similarity). Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023) 12832401,9620695,9620695 cytoplasm 20 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms STXBP5L HGNC:30757 syntaxin binding protein 5-like Q9Y2K9 Cytoplasm (Potential). Cell membrane; Peripheral membrane protein (Potential). Membrane; Peripheral membrane protein (Potential). Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane (Potential). cytoplasm 18 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms STXBP6 HGNC:19666 syntaxin binding protein 6 (amisyn) Q8NFX7 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Membrane fraction (GO:0005624) 12145319,12145319 cytoplasm 34 0 cytoplasm cytoplasm Chordata Chordata Holozoa STYK1 HGNC:18889 serine/threonine/tyrosine kinase 1 Q6J9G0 Membrane; Single-pass membrane protein (Potential). cytoplasm 14 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms STYX HGNC:11447 serine/threonine/tyrosine interacting protein Q8WUJ0 nucleus 22 0 nucleus nucleus Deuterostomia Opisthokonta Eukaryota STYXL1 HGNC:18165 serine/threonine/tyrosine interacting-like 1 Q9Y6J8 cytoplasm 12 1 cytoplasm cytoplasm Deuterostomia Deuterostomia NA SUB1 HGNC:19985 SUB1 homolog (S. cerevisiae) P53999 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 9632764,12665168,15635413,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SUCLA2 HGNC:11448 succinate-CoA ligase, ADP-forming, beta subunit Q9P2R7 Mitochondrion. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10727444,10727444 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms SUCLG1 HGNC:11449 succinate-CoA ligase, alpha subunit P53597 Mitochondrion. Mitochondrion (GO:0005739) 9128182,15598749 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SUCLG2 HGNC:11450 succinate-CoA ligase, GDP-forming, beta subunit Q96I99 Mitochondrion. Mitochondrion (GO:0005739) 9765291 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms SUCNR1 HGNC:4542 succinate receptor 1 Q9BXA5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15141213 plasma membrane 100 7 plasma membrane plasma membrane Tetrapoda Euteleostomi Metazoa SUCO HGNC:1240 SUN domain containing ossification factor Q9UBS9 Rough endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) 10673381 endoplasmic reticulum membrane 83 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Eukaryota SUDS3 HGNC:29545 suppressor of defective silencing 3 homolog (S. cerevisiae) Q9H7L9 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11909966,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa SUFU HGNC:16466 suppressor of fused homolog (Drosophila) Q9UMX1 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,12068298,10564661,11960000,,12068298,10564661 cytoplasm 36 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms SUGCT HGNC:16001 succinylCoA:glutarate-CoA transferase Q9HAC7 mitochondrion 100 0 mitochondrion mitochondrion Deuterostomia Cell.Organisms Cell.Organisms SUGP1 HGNC:18643 SURP and G patch domain containing 1 Q8IWZ8 Nucleus (Probable). Nucleus (GO:0005634) 12594045,17081983 nucleus 33 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota SUGP2 HGNC:18641 SURP and G patch domain containing 2 Q8IX01 Nucleus (Potential). Nucleus (GO:0005634) 12594045 cytoplasm 28 0 nucleus nucleus Amniota Amniota Eukaryota SUGT1 HGNC:16987 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) Q9Y2Z0 Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6. Nucleus (GO:0005634) secreted 52 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SULF1 HGNC:20391 sulfatase 1 Q8IWU6 Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell surface (By similarity). Note=Also localized on the cell surface (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12368295,12686563 secreted 11 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms SULF2 HGNC:20392 sulfatase 2 Q8IWU5 Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell surface (By similarity). Note=Also localized on the cell surface (By similarity). Extracellular (GO:0005576) 12368295 secreted 13 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms SULT1A1 HGNC:11453 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 P50225 Cytoplasm. Cytoplasm (GO:0005737) 8363592 cytoplasm 100 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms SULT1A2 HGNC:11454 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 P50226 Cytoplasm. Cytoplasm (GO:0005737) 8661000,10617600 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1A3 HGNC:11455 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 P50224 Cytoplasm. Cytoplasm (GO:0005737) 10617600 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1A4 HGNC:30004 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 P50224 Cytoplasm. Cytosol (GO:0005829) cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1B1 HGNC:17845 sulfotransferase family, cytosolic, 1B, member 1 O43704 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 9463486 cytoplasm 68 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1C2 HGNC:11456 sulfotransferase family, cytosolic, 1C, member 2 O00338 Cytoplasm. Cytoplasm (GO:0005737) 11535246,9635888 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1C3 HGNC:33543 sulfotransferase family, cytosolic, 1C, member 3 Q6IMI6 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 14676822 cytoplasm 61 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1C4 HGNC:11457 sulfotransferase family, cytosolic, 1C, member 4 O75897 Cytoplasm. Cytoplasm (GO:0005737) 10783263 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms SULT1E1 HGNC:11377 sulfotransferase family 1E, estrogen-preferring, member 1 P49888 Cytoplasm. Cytoplasm (GO:0005737) 9348232 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms SULT2A1 HGNC:11458 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 Q06520 Cytoplasm. Cytoplasm (GO:0005737) 1569919 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms SULT2B1 HGNC:11459 sulfotransferase family, cytosolic, 2B, member 1 O00204 Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829);Cytosol (GO:0005829) 15878639,15878639,12399026/12399026 secreted 39 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms SULT4A1 HGNC:14903 sulfotransferase family 4A, member 1 Q9BR01 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12039030,10698717 cytoplasm 97 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Cell.Organisms SULT6B1 HGNC:33433 sulfotransferase family, cytosolic, 6B, member 1 Q6IMI4 Cytoplasm (By similarity). cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms SUMF1 HGNC:20376 sulfatase modifying factor 1 Q8NBK3 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 12757706,12757705 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Deuterostomia Cell.Organisms Cell.Organisms SUMF2 HGNC:20415 sulfatase modifying factor 2 Q8NBJ7 Endoplasmic reticulum lumen. Endoplasmic reticulum (GO:0005783) 12757705 endoplasmic reticulum 100 0 endoplasmic reticulum endoplasmic reticulum Tetrapoda Deuterostomia Cell.Organisms SUMO1 HGNC:12502 small ubiquitin-like modifier 1 P63165 Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Note=Recruited by BCL11A into the nuclear body (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Microtubule (GO:0005874) 8812453,9019411,17081983,9019411,9465300,12383504,17081983,15561729 nucleus 47 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SUMO2 HGNC:11125 small ubiquitin-like modifier 2 P61956 Nucleus. Nucleus, PML body. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nuclear membrane (GO:0005635) ,9556629,18644859,,12383504,12383504 nucleus 100 0 cytoplasm. nucleus. nucleus membrane multiple NA NA Eukaryota SUMO3 HGNC:11124 small ubiquitin-like modifier 3 P55854 Cytoplasm. Nucleus (GO:0005634);Cytosol (GO:0005829); Nucleus (GO:0005634) ,18644859,/15561729,,18644859, cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota SUMO4 HGNC:21181 small ubiquitin-like modifier 4 Q6EEV6 Nucleus (GO:0005634) 15123604 nucleus 83 0 nucleus nucleus Human Human Eukaryota SUN1 HGNC:18587 Sad1 and UNC84 domain containing 1 O94901 Nucleus inner membrane; Single-pass type II membrane protein. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11593002,12036294 nucleus membrane 100 4 cytoplasm. nucleus. nucleus membrane multiple Euteleostomi Bilateria Eukaryota SUN2 HGNC:14210 Sad1 and UNC84 domain containing 2 Q9UH99 Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein (Probable). Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 nucleus membrane 26 3 endosome membrane. nucleus. nucleus membrane multiple Mammalia Mammalia Eukaryota SUN3 HGNC:22429 Sad1 and UNC84 domain containing 3 Q8TAQ9 Membrane; Single-pass membrane protein (Potential). nucleus membrane 32 1 nucleus membrane nucleus membrane Mammalia Eukaryota Eukaryota SUN5 HGNC:16252 Sad1 and UNC84 domain containing 5 Q8TC36 Nucleus inner membrane; Single-pass membrane protein (By similarity). Note=Restricted to the apical nuclear region of round spermatids that face the acrosomic vesicle (By similarity). nucleus membrane 72 2 nucleus membrane nucleus membrane Eutheria Mammalia Eukaryota SUOX HGNC:11460 sulfite oxidase P51687 Mitochondrion intermembrane space. Mitochondrial intermembrane space (GO:0005758) 9428520 mitochondrion 100 0 mitochondrion mitochondrion Eutheria Cell.Organisms Cell.Organisms SUPT16H HGNC:11465 suppressor of Ty 16 homolog (S. cerevisiae) Q9Y5B9 Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10421373,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms SUPT20H HGNC:20596 suppressor of Ty 20 homolog (S. cerevisiae) Q8NEM7 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta SUPT20HL1 HGNC:30773 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 Q3ZLR7 nucleus 47 0 nucleus nucleus NA NA NA SUPT3H HGNC:11466 suppressor of Ty 3 homolog (S. cerevisiae) O75486 Nucleus. Nucleus (GO:0005634) 9674425 nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Opisthokonta SUPT4H1 HGNC:11467 suppressor of Ty 4 homolog 1 (S. cerevisiae) P63272 Nucleus. Nucleus (GO:0005634) 8649394 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota SUPT5H HGNC:11469 suppressor of Ty 5 homolog (S. cerevisiae) O00267 Nucleus. Nucleus (GO:0005634) 9199507,17081983 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms SUPT6H HGNC:11470 suppressor of Ty 6 homolog (S. cerevisiae) Q7KZ85 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 38 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms SUPT7L HGNC:30632 suppressor of Ty 7 (S. cerevisiae)-like O94864 Nucleus. Nucleus (GO:0005634) 11564863,10987294 nucleus 100 0 nucleus nucleus Chordata Chordata Opisthokonta SUPV3L1 HGNC:11471 suppressor of var1, 3-like 1 (S. cerevisiae) Q8IYB8 Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 12466530,15561729,16176273 cytoplasm 32 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms SURF1 HGNC:11474 surfeit 1 Q15526 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 9843204 mitochondrion membrane 18 2 mitochondrion mitochondrion Eukaryota Cell.Organisms NA SURF2 HGNC:11475 surfeit 2 Q15527 Cytoplasm (GO:0005737) 17081983 nucleus 98 0 cytoplasm cytoplasm Chordata Chordata NA SURF4 HGNC:11476 surfeit 4 O15260 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 7540914,7540914,15561729,15598749 endoplasmic reticulum membrane 21 7 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus membrane. mitochondrion multiple Opisthokonta Opisthokonta NA SURF6 HGNC:11478 surfeit 6 O75683 Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus (By similarity). Note=Granular component of the nucleolus (By similarity). Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 15635413,11790298,9548374 nucleus 68 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia NA SUSD1 HGNC:25413 sushi domain containing 1 Q6UWL2 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 23 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SUSD2 HGNC:30667 sushi domain containing 2 Q9UGT4 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 36 1 secreted secreted Bilateria Bilateria Cell.Organisms SUSD3 HGNC:28391 sushi domain containing 3 Q96L08 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 83 1 secreted secreted Amniota Euteleostomi Euteleostomi SUSD4 HGNC:25470 sushi domain containing 4 Q5VX71 Membrane; Single-pass type I membrane protein (Potential). secreted 14 2 n/a n/a Human Euteleostomi Holozoa SUSD5 HGNC:29061 sushi domain containing 5 O60279 Membrane; Single-pass type I membrane protein. secreted 88 1 secreted secreted Amniota Euteleostomi Chordata SUV39H1 HGNC:11479 suppressor of variegation 3-9 homolog 1 (Drosophila) O43463 Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. Nucleus (GO:0005634) 10202156,17245431,16858404,17081983 nucleus 100 0 nucleus nucleus Opisthokonta Cell.Organisms NA SUV39H2 HGNC:17287 suppressor of variegation 3-9 homolog 2 (Drosophila) Q9H5I1 Nucleus (By similarity). Chromosome, centromere (By similarity). Note=Associates with centromeric constitutive heterochromatin (By similarity). Nucleus (GO:0005634) 11094092 nucleus 86 0 nucleus nucleus Opisthokonta Cell.Organisms Cell.Organisms SUV420H1 HGNC:24283 suppressor of variegation 4-20 homolog 1 (Drosophila) Q4FZB7 Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Cell.Organisms SUV420H2 HGNC:28405 suppressor of variegation 4-20 homolog 2 (Drosophila) Q86Y97 Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). nucleus 100 0 nucleus nucleus Opisthokonta Opisthokonta Cell.Organisms SUZ12 HGNC:17101 SUZ12 polycomb repressive complex 2 subunit Q15022 Nucleus. nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota SV2A HGNC:20566 synaptic vesicle glycoprotein 2A Q7L0J3 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). mitochondrion membrane 6 12 mitochondrion membrane mitochondrion membrane Deuterostomia Eukaryota NA SV2B HGNC:16874 synaptic vesicle glycoprotein 2B Q7L1I2 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). Cytoplasmic vesicle (GO:0016023) 10624962 plasma membrane 9 12 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SV2C HGNC:30670 synaptic vesicle glycoprotein 2C Q496J9 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin- secreting cells of the pancreas (By similarity). Synaptic vesicle (GO:0008021) 9801366 plasma membrane 12 12 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms SVEP1 HGNC:15985 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Q4LDE5 Secreted (Potential). Cytoplasm. Membrane; Peripheral membrane protein. Extracellular (GO:0005576) 11062057 plasma membrane 26 0 cytoplasm. secreted multiple Deuterostomia Bilateria Cell.Organisms SVIL HGNC:11480 supervillin O95425 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Note=Tightly associated with both actin filaments and plasma membranes. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12711699,17081983,12711699,12711699 cytoplasm 10 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SVIP HGNC:25238 small VCP/p97-interacting protein Q8NHG7 Smooth endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). nucleus 32 0 nucleus nucleus Euarchontoglires Amniota Eutheria SVOP HGNC:25417 SV2 related protein homolog (rat) Q8N4V2 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). plasma membrane 13 12 plasma membrane plasma membrane Chordata Cell.Organisms Cell.Organisms SVOPL HGNC:27034 SVOP-like Q8N434 Membrane; Multi-pass membrane protein (Potential). plasma membrane 13 12 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms SWAP70 HGNC:17070 SWAP switching B-cell complex 70kDa subunit Q9UH65 Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 10681448,10382743,10681448,10382743,10681448 cytoplasm 23 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota SWI5 HGNC:31412 SWI5 recombination repair homolog (yeast) Q1ZZU3 Nucleus (By similarity). nucleus 64 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota SWSAP1 HGNC:26638 SWIM-type zinc finger 7 associated protein 1 Q6NVH7 Nucleus (Probable). nucleus 18 0 nucleus nucleus Mammalia Mammalia Tetrapoda SWT1 HGNC:16785 SWT1 RNA endoribonuclease homolog (S. cerevisiae) Q5T5J6 nucleus 12 0 nucleus nucleus Amniota Opisthokonta Opisthokonta SYAP1 HGNC:16273 synapse associated protein 1 Q96A49 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 50 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota SYBU HGNC:26011 syntabulin (syntaxin-interacting) Q9NX95 Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Isoform 3: Golgi apparatus membrane; Single- pass membrane protein. Isoform 4: Golgi apparatus membrane; Single- pass membrane protein. Isoform 5: Golgi apparatus membrane; Single- pass membrane protein. cytoplasm 15 2 cytoplasm. golgi apparatus membrane multiple Euteleostomi Euteleostomi Craniata SYCE1 HGNC:28852 synaptonemal complex central element protein 1 Q8N0S2 Nucleus. Chromosome. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements (By similarity). nucleus 100 0 nucleus nucleus Eutheria Tetrapoda Euteleostomi SYCE1L HGNC:37236 synaptonemal complex central element protein 1-like A8MT33 nucleus 49 0 nucleus nucleus Catarrhini Euarchontoglires Euteleostomi SYCE2 HGNC:27411 synaptonemal complex central element protein 2 Q6PIF2 Nucleus. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity). nucleus 100 0 nucleus nucleus Mammalia Euteleostomi Eumetazoa SYCE3 HGNC:35245 synaptonemal complex central element protein 3 A1L190 Nucleus (By similarity). Chromosome (By similarity). Note=Colocalizes with SYCE1 in the central elements (By similarity). nucleus 88 0 nucleus nucleus NA NA Euteleostomi SYCN HGNC:18442 syncollin Q0VAF6 Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side (By similarity). Note=Localizes to zymogen granules (By similarity). Associated with lipid rafts in a cholesterol-dependent manner (By similarity). Zymogen granule (GO:0042588) 11839820 secreted 87 0 secreted secreted Euarchontoglires Euteleostomi Euteleostomi SYCP1 HGNC:11487 synaptonemal complex protein 1 Q15431 Nucleus (By similarity). Chromosome (By similarity). Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C- terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Nucleus (GO:0005634) 9560255 nucleus 68 0 nucleus nucleus Amniota Eukaryota Eumetazoa SYCP2 HGNC:11490 synaptonemal complex protein 2 Q9BX26 Nucleus (By similarity). Chromosome (By similarity). Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes (By similarity). Nucleus (GO:0005634) nucleus 57 0 nucleus nucleus Amniota Chordata Holozoa SYCP2L HGNC:21537 synaptonemal complex protein 2-like Q5T4T6 Nucleus. Note=Detected in nuclear granules and sizable aggregates. nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Holozoa SYCP3 HGNC:18130 synaptonemal complex protein 3 Q8IZU3 Nucleus (By similarity). Chromosome (By similarity). Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed (By similarity). nucleus 67 0 nucleus nucleus Deuterostomia Deuterostomia Holozoa SYDE1 HGNC:25824 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) Q6ZW31 secreted 18 0 secreted secreted Eutheria Euteleostomi Eukaryota SYDE2 HGNC:25841 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) Q5VT97 nucleus 16 0 nucleus nucleus Bilateria Bilateria Eukaryota SYF2 HGNC:19824 SYF2 pre-mRNA-splicing factor O95926 Nucleus. Nucleus (GO:0005634) 11118353 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota SYK HGNC:11491 spleen tyrosine kinase P43405 Cell membrane (Probable). Cytoplasm, cytosol (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 10689303,16713566,16713566,16713566 plasma membrane 22 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms SYMPK HGNC:22935 symplekin Q92797 Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8769423,8769423,8769423 nucleus 23 1 cytoplasm. nucleus. plasma membrane multiple Theria Eukaryota Eukaryota SYN1 HGNC:11494 synapsin I P17600 Cell junction, synapse. Golgi apparatus (By similarity). Cytoplasm (GO:0005737) 8287627 secreted 63 0 cytoplasm cytoplasm Theria Bilateria Cell.Organisms SYN2 HGNC:11495 synapsin II Q92777 Cell junction, synapse. Synaptic vesicle (GO:0008021);Synaptic vesicle (GO:0008021) 8964517/8964517,10571231,9430678 secreted 100 0 secreted secreted Bilateria Eukaryota Cell.Organisms SYN3 HGNC:11496 synapsin III O14994 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles. Synaptic vesicle (GO:0008021) 9539796 secreted 51 0 secreted secreted Bilateria Eukaryota Cell.Organisms SYNC HGNC:28897 syncoilin, intermediate filament protein Q9H7C4 Cytoplasm, perinuclear region (By similarity). Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11053421,11694502 cytoplasm 73 0 cytoplasm cytoplasm Theria Euteleostomi Craniata SYNCRIP HGNC:16918 synaptotagmin binding, cytoplasmic RNA interacting protein O60506 Cytoplasm. Microsome (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity). Isoform 1: Nucleus, nucleoplasm (By similarity). Isoform 2: Nucleus, nucleoplasm (By similarity). Isoform 3: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Ribosome (GO:0005840); Nucleolus (GO:0005730) 11051545,10734137,11994298,11994298,11994298,15635413 nucleus 41 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Eukaryota Cell.Organisms SYNDIG1 HGNC:15885 synapse differentiation inducing 1 Q9H7V2 Cell membrane; Single-pass type II membrane protein. Early endosome membrane; Single-pass type II membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Shuttles between the cell surface and early endosome membrane (By similarity). plasma membrane 80 2 plasma membrane plasma membrane Amniota Euteleostomi Metazoa SYNDIG1L HGNC:32388 synapse differentiation inducing 1-like A6NDD5 Membrane; Multi-pass membrane protein (Potential). Golgi apparatus, cis-Golgi network (By similarity). plasma membrane 83 2 plasma membrane plasma membrane Theria Euteleostomi Metazoa SYNE1 HGNC:17089 spectrin repeat containing, nuclear envelope 1 Q8NF91 Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (Potential). Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere. Note=The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. In skeletal and smooth muscles, a significant amount is found in the sarcomeres. In myoblasts, relocalized from the nuclear envelope to the nucleus and cytoplasm during cell differentiation. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730);Golgi apparatus (GO:0005794); Sarcoplasmic reticulum (GO:0016529); Cytoskeleton (GO:0005856); Nucleus (GO:0005634);Nucleus (GO:0005634); Sarcoplasmic reticulum (GO:0016529) 11792814,11792814,11792814/12808039,12408964,15093733,12408964,10878022,15093733,17081983/12408964,12408964 cytoplasm 20 1 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Deuterostomia Bilateria Eukaryota SYNE2 HGNC:17084 spectrin repeat containing, nuclear envelope 2 Q8WXH0 Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (Potential). Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential). Cell membrane; Single-pass membrane protein (Potential). Cytoplasm, cytoskeleton. Mitochondrion. Nucleus, nucleoplasm. Note=Different isoform patterns are found in the different compartments of the cell. The isoforms having the C- terminal transmembrane span can be found in several organellar membranes like the nuclear envelope, the sarcoplasmic reticulum of myoblasts, or the lamellipodia and focal adhesions at the cell membrane. The largest part of the outer nuclear membrane- associated protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Shorter solubles isoforms can be found in the cytoplasm and within the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634);Sarcoplasmic reticulum (GO:0016529); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 17081983,17081983/17081983/15671068,15671068,12118075,15671068,11792814,17081983,12118075,12118075,15671068 cytoplasm 27 1 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus. plasma membrane multiple Deuterostomia Bilateria Eukaryota SYNE3 HGNC:19861 spectrin repeat containing, nuclear envelope family member 3 Q6ZMZ3 Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Note=Localized uniformly throughout the nuclear envilope in aortic endothelial cells. Located at the rough reticulum endoplasmic (RER) in some cells. Cytoskeleton (GO:0005856) cytoplasm 10 1 nucleus membrane nucleus membrane Euteleostomi Euteleostomi Eumetazoa SYNE4 HGNC:26703 spectrin repeat containing, nuclear envelope family member 4 Q8N205 Nucleus outer membrane; Single-pass type IV membrane protein (By similarity). Note=The nucleus outer membrane location requires the presence of a SUN domain-containing protein (By similarity). nucleus membrane 60 1 nucleus membrane nucleus membrane Eutheria Mammalia Euteleostomi SYNGAP1 HGNC:11497 synaptic Ras GTPase activating protein 1 Q96PV0 Cytoplasmic vesicle (GO:0016023) 15014045 cytoplasm 23 1 cytoplasm cytoplasm Euteleostomi Bilateria NA SYNGR1 HGNC:11498 synaptogyrin 1 O43759 Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Integral to membrane (GO:0016021) 14732601 plasma membrane 24 4 melanosome melanosome Euteleostomi Euteleostomi Holozoa SYNGR2 HGNC:11499 synaptogyrin 2 O43760 Membrane; Multi-pass membrane protein. Cytoplasmic vesicle (By similarity). Plasma membrane (GO:0005886) 9760194 endoplasmic reticulum membrane 24 4 plasma membrane plasma membrane Bilateria Bilateria Holozoa SYNGR3 HGNC:11501 synaptogyrin 3 O43761 Membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse. Note=Found at the neuromuscular synapses (By similarity). Plasma membrane (GO:0005886) plasma membrane 26 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa SYNGR4 HGNC:11502 synaptogyrin 4 O95473 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 35 4 plasma membrane plasma membrane Theria Theria Holozoa SYNJ1 HGNC:11503 synaptojanin 1 O43426 Cytoplasm (By similarity). Synaptic vesicle (GO:0008021); Nucleus (GO:0005634) 9428629,17081983 cytoplasm 88 2 nucleus nucleus Euteleostomi Eukaryota Eukaryota SYNJ2 HGNC:11504 synaptojanin 2 O15056 Membrane (By similarity). Note=Predominantly associated with the particulate fractions (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11084340,11084340,10357812 cytoplasm 37 1 cytoplasm. mitochondrion. plasma membrane multiple Euteleostomi Eukaryota Eukaryota SYNJ2BP HGNC:18955 synaptojanin 2 binding protein P57105 Mitochondrion outer membrane (By similarity). Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11882656,10357812 cytoplasm 28 1 cytoplasm. mitochondrion multiple Mammalia Chordata Holozoa SYNM HGNC:24466 synemin, intermediate filament protein O15061 Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Intermediate filament (GO:0005882); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/11353857,17081983,17081983 cytoplasm 15 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eumetazoa SYNPO HGNC:30672 synaptopodin Q8N3V7 Cytoplasm, cytoskeleton (By similarity). Cell junction, tight junction (By similarity). Perikaryon (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoskeleton (GO:0005856); Plasma membrane (GO:0005886) 17081983,17081983/9314539,9314539 secreted 8 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Craniata SYNPO2 HGNC:17732 synaptopodin 2 Q9UMS6 Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber- like pattern. partly overlapping with filamentous actin. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11673475,12917631,12637565,11673475,12917631,12637565 cytoplasm 20 0 cytoplasm. nucleus multiple Amniota Euteleostomi Holozoa SYNPO2L HGNC:23532 synaptopodin 2-like Q9H987 Cytoplasm, cytoskeleton (By similarity). cytoplasm 26 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Holozoa SYNPR HGNC:16507 synaptoporin Q8TBG9 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasmic vesicle (GO:0016023) 12271488 endoplasmic reticulum membrane 36 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eumetazoa SYNRG HGNC:557 synergin, gamma Q9UMZ2 Cytoplasm (By similarity). Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Note=Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1 (By similarity). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 10747088,10477754,10747088,10477754 cytoplasm 14 0 golgi apparatus golgi apparatus Deuterostomia Deuterostomia Opisthokonta SYP HGNC:11506 synaptophysin P08247 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Nucleus (GO:0005634); Endosome (GO:0005768); Cytoplasm (GO:0005737) 12097487,11786535,9930883 secreted 35 4 cytoplasm. endosome. nucleus multiple Theria Deuterostomia NA SYPL1 HGNC:11507 synaptophysin-like 1 Q16563 Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Microsome (GO:0005792); Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Endoplasmic reticulum (GO:0005783); Golgi vesicle (GO:0005798); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 10636906,10370136,8707851,10636906,8707851,8707851,8707851,8707851,8707851,8707851 endoplasmic reticulum membrane 52 4 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus. melanosome. plasma membrane multiple Euteleostomi Bilateria Opisthokonta SYPL2 HGNC:27638 synaptophysin-like 2 Q5VXT5 Membrane; Multi-pass membrane protein (By similarity). Note=Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 50 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Tetrapoda Metazoa SYS1 HGNC:16162 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Q8N2H4 Golgi apparatus membrane; Multi-pass membrane protein. golgi apparatus membrane 100 4 golgi apparatus membrane golgi apparatus membrane Theria Amniota Eukaryota SYT1 HGNC:11509 synaptotagmin I P21579 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules. Cytoplasmic vesicle (GO:0016023); Chromaffin granule (GO:0042583) 8769138,17449848 cytoplasm 18 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota SYT10 HGNC:19266 synaptotagmin X Q6XYQ8 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Integral to membrane (GO:0016021) cytoplasm 18 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota SYT11 HGNC:19239 synaptotagmin XI Q9BT88 Membrane; Single-pass membrane protein. Cell junction, synapse (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients. Cytoplasmic vesicle (GO:0016023); Cytoplasm (GO:0005737) 12925569,12925569 cytoplasm 22 1 cytoplasm cytoplasm Theria Bilateria Eukaryota SYT12 HGNC:18381 synaptotagmin XII Q8IV01 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). plasma membrane 19 1 plasma membrane plasma membrane Amniota Bilateria Holozoa SYT13 HGNC:14962 synaptotagmin XIII Q7L8C5 Membrane; Single-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) 11171101,11171101 plasma membrane 29 0 golgi apparatus golgi apparatus Tetrapoda Euteleostomi Metazoa SYT14 HGNC:23143 synaptotagmin XIV Q8NB59 Membrane; Single-pass type III membrane protein. Note=Localized in perinuclear and submembranous regions. Plasma membrane (GO:0005886) 12801916 nucleus 6 2 plasma membrane plasma membrane Euteleostomi Deuterostomia Metazoa SYT15 HGNC:17167 synaptotagmin XV Q9BQS2 Isoform 1: Cell membrane; Single-pass type III membrane protein (By similarity). Isoform 2: Cell membrane; Single-pass type III membrane protein (By similarity). Isoform 4: Cell membrane; Single-pass type III membrane protein (By similarity). Integral to membrane (GO:0016021) 12788067 cytoplasm 30 1 cytoplasm cytoplasm Deuterostomia Deuterostomia NA SYT16 HGNC:23142 synaptotagmin XVI Q17RD7 Plasma membrane (GO:0005886) 12801916 nucleus 2 1 plasma membrane plasma membrane Chordata Bilateria Metazoa SYT17 HGNC:24119 synaptotagmin XVII Q9BSW7 Membrane; Peripheral membrane protein (By similarity). plasma membrane 19 0 n/a n/a Amniota Deuterostomia Eukaryota SYT2 HGNC:11510 synaptotagmin II Q8N9I0 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein (By similarity). Note=Synaptic vesicles and chromaffin granules (By similarity). Secretory granule (GO:0030141); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Lysosome (GO:0005764) 12063179,12063179,11696368,10952998,10330444 secreted 18 1 endoplasmic reticulum. lysosome. plasma membrane multiple Mammalia Mammalia Eukaryota SYT3 HGNC:11511 synaptotagmin III Q9BQG1 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Integral to membrane (GO:0016021) cytoplasm 23 1 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota SYT4 HGNC:11512 synaptotagmin IV Q9H2B2 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle (GO:0016023) 10938284 cytoplasm 19 1 cytoplasm cytoplasm Amniota Bilateria Eukaryota SYT5 HGNC:11513 synaptotagmin V O00445 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Recycling endosome membrane; Single-pass membrane protein (By similarity). Note=In mast cells, localizes to the endocytic recycling compartment (By similarity). Plasma membrane (GO:0005886) 10556508 secreted 17 1 plasma membrane plasma membrane Eutheria Eutheria Eukaryota SYT6 HGNC:18638 synaptotagmin VI Q5T7P8 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Isoform 1: Membrane; Single-pass membrane protein (By similarity). Isoform 2: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By similarity). cytoplasm 20 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota SYT7 HGNC:11514 synaptotagmin VII O43581 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Endosome (GO:0005768); Lysosome (GO:0005764); Chromaffin granule (GO:0042583); Membrane fraction (GO:0005624); Cytosol (GO:0005829) 12071850,11342594,17449848,17449848,17449848 secreted 23 1 cytoplasm. endosome. lysosome multiple Deuterostomia Bilateria Eukaryota SYT8 HGNC:19264 synaptotagmin VIII Q8NBV8 Cell membrane; Single-pass type III membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Extracellular (GO:0005576) 15822942 plasma membrane 29 1 secreted secreted Human Human Eukaryota SYT9 HGNC:19265 synaptotagmin IX Q86SS6 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endosome (GO:0005768) 11751925,12966166,12966166,12966166 cytoplasm 25 1 cytoplasm. endosome. plasma membrane multiple Mammalia Deuterostomia Eukaryota SYTL1 HGNC:15584 synaptotagmin-like 1 Q8IYJ3 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes. Plasma membrane (GO:0005886) 12189202,16004602 cytoplasm 21 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota SYTL2 HGNC:15585 synaptotagmin-like 2 Q9HCH5 Isoform 1: Cytoplasm. Cell membrane. Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. Endosome (GO:0005768) 11773082 secreted 28 0 cytoplasm. endosome multiple Euteleostomi Euteleostomi Holozoa SYTL3 HGNC:15587 synaptotagmin-like 3 Q4VX76 Endomembrane system; Peripheral membrane protein (By similarity). secreted 12 0 secreted secreted Bilateria Bilateria Opisthokonta SYTL4 HGNC:15588 synaptotagmin-like 4 Q96C24 Membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By similarity). Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). Secretory granule (GO:0030141) 10497219 secreted 18 0 secreted secreted Euteleostomi Bilateria Eukaryota SYTL5 HGNC:15589 synaptotagmin-like 5 Q8TDW5 Membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle (GO:0016023) 12051743 cytoplasm 18 0 cytoplasm cytoplasm Chordata Chordata Eukaryota SYVN1 HGNC:20738 synovial apoptosis inhibitor 1, synoviolin Q86TM6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 14593114,12459480 endoplasmic reticulum membrane 100 5 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Eukaryota Eukaryota SZRD1 HGNC:30232 SUZ RNA binding domain containing 1 Q7Z422 cytoplasm 33 0 cytoplasm cytoplasm Chordata Bilateria Eumetazoa SZT2 HGNC:29040 seizure threshold 2 homolog (mouse) Q5T011 Peroxisome (By similarity). peroxisome 90 0 peroxisome peroxisome Euteleostomi Bilateria Eukaryota T HGNC:11515 T, brachyury homolog (mouse) O15178 Nucleus. Nucleus (GO:0005634) 1516477 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Holozoa TAAR1 HGNC:17734 trace amine associated receptor 1 Q96RJ0 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) ,11723224 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa TAAR2 HGNC:4514 trace amine associated receptor 2 Q9P1P5 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Mammalia Euteleostomi Metazoa TAAR3 HGNC:4513 trace amine associated receptor 3 (gene/pseudogene) Q9P1P4 Cell membrane; Multi-pass membrane protein (By similarity). plasma membrane 51 7 plasma membrane plasma membrane NA NA NA TAAR5 HGNC:30236 trace amine associated receptor 5 O14804 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Amniota Eumetazoa TAAR6 HGNC:20978 trace amine associated receptor 6 Q96RI8 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Metazoa TAAR8 HGNC:14964 trace amine associated receptor 8 Q969N4 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11459929 plasma membrane 100 7 plasma membrane plasma membrane Theria Theria Metazoa TAAR9 HGNC:20977 trace amine associated receptor 9 (gene/pseudogene) Q96RI9 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 100 7 plasma membrane plasma membrane NA NA Metazoa TAB1 HGNC:18157 TGF-beta activated kinase 1/MAP3K7 binding protein 1 Q15750 Cytoplasm (GO:0005737) 11518704 mitochondrion 20 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota TAB2 HGNC:17075 TGF-beta activated kinase 1/MAP3K7 binding protein 2 Q9NYJ8 Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10882101,10882101 secreted 9 0 cytoplasm cytoplasm Chordata Chordata Bilateria TAB3 HGNC:30681 TGF-beta activated kinase 1/MAP3K7 binding protein 3 Q8N5C8 nucleus 22 0 nucleus nucleus Human Human Bilateria TAC1 HGNC:11517 tachykinin, precursor 1 P20366 Secreted. Extracellular (GO:0005576) 9548509 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Euteleostomi TAC3 HGNC:11521 tachykinin 3 Q9UHF0 Secreted. Extracellular (GO:0005576) 12727971,10866201,14634580 secreted 100 0 secreted secreted Mammalia Mammalia Euteleostomi TAC4 HGNC:16641 tachykinin 4 (hemokinin) Q86UU9 Secreted (Probable). Extracellular (GO:0005576) secreted 86 0 secreted secreted Euarchontoglires Eutheria Eutheria TACC1 HGNC:11522 transforming, acidic coiled-coil containing protein 1 O75410 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. Nucleus (GO:0005634); Centrosome (GO:0005813); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10435627,15064709,15064709,15064709,12165861,17081983 cytoplasm 43 0 cytoplasm. nucleus multiple Amniota Euteleostomi Cell.Organisms TACC2 HGNC:11523 transforming, acidic coiled-coil containing protein 2 O95359 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 10637228,10637228,12620397,10749935 cytoplasm 41 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota TACC3 HGNC:11524 transforming, acidic coiled-coil containing protein 3 Q9Y6A5 Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12711550,11847113,11121038 cytoplasm 44 0 cytoplasm. nucleus multiple Human Human Opisthokonta TACO1 HGNC:24316 translational activator of mitochondrially encoded cytochrome c oxidase I Q9BSH4 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms TACR1 HGNC:11526 tachykinin receptor 1 P25103 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 15590676 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Eumetazoa TACR2 HGNC:11527 tachykinin receptor 2 P21452 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 1661704 plasma membrane 100 7 plasma membrane plasma membrane Amniota Deuterostomia Metazoa TACR3 HGNC:11528 tachykinin receptor 3 P29371 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 8925404 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Bilateria Eumetazoa TACSTD2 HGNC:11530 tumor-associated calcium signal transducer 2 P09758 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 7665234,10192395,17081983 secreted 40 1 cytoplasm. plasma membrane multiple Human Human Craniata TADA1 HGNC:30631 transcriptional adaptor 1 Q96BN2 Nucleus. Nucleus (GO:0005634) 11564863 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta TADA2A HGNC:11531 transcriptional adaptor 2A O75478 Nucleus. Chromosome. Nucleus (GO:0005634) 9073520 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TADA2B HGNC:30781 transcriptional adaptor 2B Q86TJ2 Nucleus (Probable). nucleus 30 0 nucleus nucleus Human Human Eukaryota TADA3 HGNC:19422 transcriptional adaptor 3 O75528 Nucleus. Nucleus (GO:0005634) 9674425 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota TAF1 HGNC:11535 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa P21675 Nucleus. Nucleolus (GO:0005730); Kinetochore (GO:0000776); Nucleus (GO:0005634) 12498690,11780067,3169001,10827952,2038334 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TAF10 HGNC:11543 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa Q12962 Nucleus. Nucleus (GO:0005634) 7923369,15115762 nucleus 100 0 nucleus nucleus Theria Eukaryota Eukaryota TAF11 HGNC:11544 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa Q15544 Nucleus. Nucleus (GO:0005634) 7729427,8820923 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota TAF12 HGNC:11545 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa Q16514 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TAF13 HGNC:11546 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa Q15543 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TAF15 HGNC:11547 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa Q92804 Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730) 15094065,19059367,15635413 nucleus 67 0 cytoplasm. nucleus multiple Euteleostomi Bilateria NA TAF1A HGNC:11532 TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa Q15573 Nucleus. Nucleolus (GO:0005730); Nucleoplasm (GO:0005654) 15113842,15113842 nucleus 100 0 nucleus nucleus Chordata Chordata Holozoa TAF1B HGNC:11533 TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Q53T94 Nucleus, nucleolus. Nucleus (GO:0005634) 10913176 nucleus 100 1 nucleus nucleus Chordata Chordata Eumetazoa TAF1C HGNC:11534 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa Q15572 Nucleus. Nucleus (GO:0005634) 10913176 nucleus 100 0 nucleus nucleus Theria Amniota Eumetazoa TAF1D HGNC:28759 TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa Q9H5J8 Nucleus. Nucleus (GO:0005634) 15520167,17318177 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Tetrapoda TAF1L HGNC:18056 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like Q8IZX4 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 94 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TAF2 HGNC:11536 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa Q6P1X5 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9418870,9774672,17081983 nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms TAF3 HGNC:17303 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa Q5VWG9 Nucleus. Nucleus (GO:0005634) 15870280 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota TAF4 HGNC:11537 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa O00268 Nucleus. Nucleus (GO:0005634) 8942982 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota TAF4B HGNC:11538 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa Q92750 Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11567023,11567023 nucleus 39 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota TAF5 HGNC:11539 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa Q15542 Nucleus. Nucleus (GO:0005634) 8942982,9045704 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms TAF5L HGNC:17304 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa O75529 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Chordata Chordata Cell.Organisms TAF6 HGNC:11540 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa P49848 Nucleus. Nucleus (GO:0005634) 11583621 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TAF6L HGNC:17305 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa Q9Y6J9 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Deuterostomia Eukaryota TAF7 HGNC:11541 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa Q15545 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7824954,8702684,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota TAF7L HGNC:11548 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa Q5H9L4 Nucleus (By similarity). Cytoplasm (By similarity). Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12665565,12665565 nucleus 55 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota TAF8 HGNC:17300 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa Q7Z7C8 Nucleus. Cytoplasm (By similarity). Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell (By similarity). Nucleus (GO:0005634) 14580349 nucleus 31 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TAF9 HGNC:11542 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa Q16594 Nucleus. Nucleus (GO:0005634); Nucleoplasm (GO:0005654) 7597030,16079131 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota NA TAF9B HGNC:17306 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa Q9HBM6 Nucleus (By similarity). Nucleus (GO:0005634) 12837753 nucleus 78 0 nucleus nucleus Opisthokonta Eukaryota NA TAGAP HGNC:15669 T-cell activation RhoGTPase activating protein Q8N103 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota TAGLN HGNC:11553 transgelin Q01995 Cytoplasm (Probable). Cytoplasm (GO:0005737) 11053353,1520290 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TAGLN2 HGNC:11554 transgelin 2 P37802 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota TAGLN3 HGNC:29868 transgelin 3 Q9UI15 Cytoplasm (GO:0005737) 14506410 cytoplasm 19 0 cytoplasm cytoplasm Amniota Bilateria Eukaryota TAL1 HGNC:11556 T-cell acute lymphocytic leukemia 1 P17542 Nucleus (By similarity). Nucleus (GO:0005634) 7833471,1450410 nucleus 92 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa TAL2 HGNC:11557 T-cell acute lymphocytic leukemia 2 Q16559 Nucleus (GO:0005634) 1450410 nucleus 65 0 nucleus nucleus Euteleostomi Bilateria Metazoa TALDO1 HGNC:11559 transaldolase 1 P37837 Cytoplasm (Probable). Nucleus (GO:0005634) 17081983 cytoplasm 78 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms TAMM41 HGNC:25187 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) Q96BW9 Mitochondrion (By similarity). mitochondrion 77 0 mitochondrion mitochondrion Opisthokonta Eukaryota NA TANC1 HGNC:29364 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Q9C0D5 Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Extracellular (GO:0005576) 15673434 mitochondrion 24 0 secreted secreted Tetrapoda Opisthokonta Cell.Organisms TANC2 HGNC:30212 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Q9HCD6 mitochondrion 18 2 mitochondrion mitochondrion Tetrapoda Opisthokonta Cell.Organisms TANGO2 HGNC:25439 transport and golgi organization 2 homolog (Drosophila) Q6ICL3 secreted 65 0 secreted secreted Bilateria Cell.Organisms Cell.Organisms TANGO6 HGNC:25749 transport and golgi organization 6 homolog (Drosophila) Q9C0B7 Membrane; Single-pass membrane protein (Potential). nucleus 80 2 nucleus nucleus Euteleostomi Eukaryota Eukaryota TANK HGNC:11562 TRAF family member-associated NFKB activator Q92844 Cytoplasm. Cytoplasm (GO:0005737) 8710854,17081983 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Euteleostomi TAOK1 HGNC:29259 TAO kinase 1 Q7L7X3 Cytoplasm. Nucleus (GO:0005634) 17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms TAOK2 HGNC:16835 TAO kinase 2 Q9UL54 Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytoskeleton. Nucleus. Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8 (By similarity). Cytoplasmic vesicle (GO:0016023); Microtubule (GO:0005874) 10660600,12639963 cytoplasm 69 5 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms TAOK3 HGNC:18133 TAO kinase 3 Q9H2K8 Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane. cytoplasm 66 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms TAP1 HGNC:43 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Q03518 Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 8453065,8453065,15561729 endoplasmic reticulum membrane 100 10 cytoplasm. endoplasmic reticulum membrane. plasma membrane multiple Tetrapoda Euteleostomi NA TAP2 HGNC:44 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Q03519 Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane. Integral to membrane (GO:0016021);Integral to membrane (GO:0016021);Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 1946428//11133832,11133832 endoplasmic reticulum membrane 100 8 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane multiple Amniota Euteleostomi NA TAPBP HGNC:11566 TAP binding protein (tapasin) O15533 Endoplasmic reticulum membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 11884415,9238042,12213826,11884415 plasma membrane 66 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Euteleostomi Euteleostomi NA TAPBPL HGNC:30683 TAP binding protein-like Q9BX59 Cell membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum membrane; Single-pass type I membrane protein (Probable). Microsome membrane; Single- pass type I membrane protein (Probable). Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface. Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 11920573,11920573 plasma membrane 23 1 endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane multiple Tetrapoda Euteleostomi Metazoa TAPT1 HGNC:26887 transmembrane anterior posterior transformation 1 Q6NXT6 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 24 8 mitochondrion membrane mitochondrion membrane Eukaryota Eukaryota Eukaryota TARBP1 HGNC:11568 TAR (HIV-1) RNA binding protein 1 Q13395 Nucleus (GO:0005634) 8626763 cytoplasm 25 0 nucleus nucleus Tetrapoda Cell.Organisms Cell.Organisms TARBP2 HGNC:11569 TAR (HIV-1) RNA binding protein 2 Q15633 Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11228241,16424907,11228241 cytoplasm 42 0 cytoplasm. nucleus multiple Eutheria Euteleostomi Cell.Organisms TARDBP HGNC:11571 TAR DNA binding protein Q13148 Nucleus. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies. Nucleus (GO:0005634) 11285240,17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms TARM1 HGNC:37250 T cell-interacting, activating receptor on myeloid cells 1 B6A8C7 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 24 1 plasma membrane plasma membrane NA NA NA TARS HGNC:11572 threonyl-tRNA synthetase P26639 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Ribosome (GO:0005840) 2033077,15598749,15561729 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms TARS2 HGNC:30740 threonyl-tRNA synthetase 2, mitochondrial (putative) Q9BW92 Mitochondrion matrix (By similarity). cytoplasm 44 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms TARSL2 HGNC:24728 threonyl-tRNA synthetase-like 2 A2RTX5 Cytoplasm (By similarity). cytoplasm 68 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms TAS1R1 HGNC:14448 taste receptor, type 1, member 1 Q7RTX1 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11894099 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eukaryota TAS1R2 HGNC:14905 taste receptor, type 1, member 2 Q8TE23 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10052456 plasma membrane 100 7 plasma membrane plasma membrane Mammalia Mammalia Eukaryota TAS1R3 HGNC:15661 taste receptor, type 1, member 3 Q7RTX0 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Theria Euteleostomi Eukaryota TAS2R1 HGNC:14909 taste receptor, type 2, member 1 Q9NYW7 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10766242,10761934 plasma membrane 16 7 plasma membrane plasma membrane Amniota Amniota Tetrapoda TAS2R10 HGNC:14918 taste receptor, type 2, member 10 Q9NYW0 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 27 7 plasma membrane plasma membrane Theria Theria NA TAS2R13 HGNC:14919 taste receptor, type 2, member 13 Q9NYV9 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 49 7 plasma membrane plasma membrane Euarchontoglires Euarchontoglires NA TAS2R14 HGNC:14920 taste receptor, type 2, member 14 Q9NYV8 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 33 7 plasma membrane plasma membrane Euarchontoglires Eutheria NA TAS2R16 HGNC:14921 taste receptor, type 2, member 16 Q9NYV7 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 12 7 plasma membrane plasma membrane Theria Theria Tetrapoda TAS2R19 HGNC:19108 taste receptor, type 2, member 19 P59542 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 31 7 plasma membrane plasma membrane Catarrhini Eutheria NA TAS2R20 HGNC:19109 taste receptor, type 2, member 20 P59543 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 27 7 plasma membrane plasma membrane NA NA NA TAS2R3 HGNC:14910 taste receptor, type 2, member 3 Q9NYW6 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 21 7 plasma membrane plasma membrane Theria Theria Tetrapoda TAS2R30 HGNC:19112 taste receptor, type 2, member 30 P59541 Membrane; Multi-pass membrane protein. plasma membrane 28 7 plasma membrane plasma membrane NA NA NA TAS2R31 HGNC:19113 taste receptor, type 2, member 31 P59538 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 28 7 plasma membrane plasma membrane NA NA NA TAS2R38 HGNC:9584 taste receptor, type 2, member 38 P59533 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12595690 plasma membrane 14 7 plasma membrane plasma membrane NA NA NA TAS2R39 HGNC:18886 taste receptor, type 2, member 39 P59534 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 16 7 plasma membrane plasma membrane NA NA Tetrapoda TAS2R4 HGNC:14911 taste receptor, type 2, member 4 Q9NYW5 Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia. Plasma membrane (GO:0005886) plasma membrane 14 7 plasma membrane plasma membrane Euarchontoglires Eutheria Tetrapoda TAS2R40 HGNC:18885 taste receptor, type 2, member 40 P59535 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 17 7 plasma membrane plasma membrane NA NA Tetrapoda TAS2R41 HGNC:18883 taste receptor, type 2, member 41 P59536 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 20 7 plasma membrane plasma membrane NA NA Tetrapoda TAS2R42 HGNC:18888 taste receptor, type 2, member 42 Q7RTR8 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 15 7 plasma membrane plasma membrane Human Eutheria Tetrapoda TAS2R43 HGNC:18875 taste receptor, type 2, member 43 P59537 Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia. Integral to membrane (GO:0016021) plasma membrane 29 7 plasma membrane plasma membrane NA NA NA TAS2R45 HGNC:18876 taste receptor, type 2, member 45 P59539 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 27 7 plasma membrane plasma membrane NA NA NA TAS2R46 HGNC:18877 taste receptor, type 2, member 46 P59540 Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia. Integral to membrane (GO:0016021) plasma membrane 28 7 plasma membrane plasma membrane NA NA NA TAS2R5 HGNC:14912 taste receptor, type 2, member 5 Q9NYW4 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) plasma membrane 18 7 plasma membrane plasma membrane Catarrhini Eutheria Tetrapoda TAS2R50 HGNC:18882 taste receptor, type 2, member 50 P59544 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 29 7 plasma membrane plasma membrane Catarrhini Catarrhini NA TAS2R60 HGNC:20639 taste receptor, type 2, member 60 P59551 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12584440 plasma membrane 13 7 plasma membrane plasma membrane Theria Theria Tetrapoda TAS2R7 HGNC:14913 taste receptor, type 2, member 7 Q9NYW3 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10766242 plasma membrane 28 7 plasma membrane plasma membrane Theria Tetrapoda NA TAS2R8 HGNC:14915 taste receptor, type 2, member 8 Q9NYW2 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10766242 plasma membrane 20 7 plasma membrane plasma membrane Catarrhini Catarrhini NA TAS2R9 HGNC:14917 taste receptor, type 2, member 9 Q9NYW1 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10766242 plasma membrane 23 7 plasma membrane plasma membrane Catarrhini Catarrhini NA TASP1 HGNC:15859 taspase, threonine aspartase, 1 Q9H6P5 Nucleolus (GO:0005730) 15635413 cytoplasm 29 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms TAT HGNC:11573 tyrosine aminotransferase P17735 Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 4389443,1356171,6124417,4389443 mitochondrion 5 0 cytoplasm. mitochondrion multiple Bilateria Cell.Organisms Cell.Organisms TATDN1 HGNC:24220 TatD DNase domain containing 1 Q6P1N9 Nucleus (Potential). cytoplasm 29 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms TATDN2 HGNC:28988 TatD DNase domain containing 2 Q93075 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 20 0 cytoplasm cytoplasm Mammalia Cell.Organisms Cell.Organisms TATDN3 HGNC:27010 TatD DNase domain containing 3 Q17R31 Nucleus (Potential). cytoplasm 34 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms TAX1BP1 HGNC:11575 Tax1 (human T-cell leukemia virus type I) binding protein 1 Q86VP1 Nucleus (GO:0005634) 11893730 cytoplasm 15 0 nucleus nucleus Euteleostomi Deuterostomia Metazoa TAX1BP3 HGNC:30684 Tax1 (human T-cell leukemia virus type I) binding protein 3 O14907 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10940294,12874278,12874278 cytoplasm 20 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Holozoa TAZ HGNC:11577 tafazzin Q16635 Isoform 1: Membrane; Single-pass membrane protein. Isoform 2: Cytoplasm (Probable). Isoform 3: Membrane; Single-pass membrane protein. Isoform 4: Membrane; Single-pass membrane protein. Isoform 5: Membrane; Single-pass membrane protein. Isoform 6: Cytoplasm (Probable). Isoform 7: Membrane; Single-pass membrane protein. Isoform 8: Cytoplasm (Probable). Isoform 9: Cytoplasm (Probable). Mitochondrion (GO:0005739) 10407787,11896212 plasma membrane 25 1 cytoplasm. mitochondrion multiple Bilateria Eukaryota Cell.Organisms TBATA HGNC:23511 thymus, brain and testes associated Q96M53 Cytoplasm, cytosol (By similarity). nucleus 71 0 nucleus nucleus Eutheria Deuterostomia Euteleostomi TBC1D1 HGNC:11578 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 Q86TI0 Nucleus (By similarity). Endoplasmic reticulum (GO:0005783) 15561729 nucleus 84 1 endoplasmic reticulum endoplasmic reticulum Euteleostomi Bilateria Eukaryota TBC1D10A HGNC:23609 TBC1 domain family, member 10A Q9BXI6 Cell projection, microvillus. Note=Localizes to the microvilli-rich region of the syncytiotrophoblast. In melanocytes, located at the periphery of cells. cytoplasm 59 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D10B HGNC:24510 TBC1 domain family, member 10B Q4KMP7 Cytoplasm. Note=In melanocytes, located at the periphery of cells. cytoplasm 100 3 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D10C HGNC:24702 TBC1 domain family, member 10C Q8IV04 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17230191,17230191 cytoplasm 39 0 cytoplasm. nucleus multiple Theria Euteleostomi Eukaryota TBC1D12 HGNC:29082 TBC1 domain family, member 12 O60347 golgi apparatus 63 0 golgi apparatus golgi apparatus Opisthokonta Eukaryota Eukaryota TBC1D13 HGNC:25571 TBC1 domain family, member 13 Q9NVG8 cytoplasm 29 2 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TBC1D14 HGNC:29246 TBC1 domain family, member 14 Q9P2M4 Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Note=After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation. golgi apparatus 100 1 golgi apparatus golgi apparatus Opisthokonta Eukaryota Eukaryota TBC1D15 HGNC:25694 TBC1 domain family, member 15 Q8TC07 Cytoplasm (By similarity). cytoplasm 90 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TBC1D16 HGNC:28356 TBC1 domain family, member 16 Q8TBP0 cytoplasm 22 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota TBC1D17 HGNC:25699 TBC1 domain family, member 17 Q9HA65 cytoplasm 40 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TBC1D19 HGNC:25624 TBC1 domain family, member 19 Q8N5T2 nucleus 31 4 nucleus nucleus Deuterostomia Eukaryota Eukaryota TBC1D2 HGNC:18026 TBC1 domain family, member 2 Q9BYX2 Cytoplasm. Cytoplasmic vesicle. Cell junction. cytoplasm 24 1 cytoplasm cytoplasm Amniota Eukaryota Eukaryota TBC1D20 HGNC:16133 TBC1 domain family, member 20 Q96BZ9 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 16 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota TBC1D21 HGNC:28536 TBC1 domain family, member 21 Q8IYX1 cytoplasm 10 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota TBC1D22A HGNC:1309 TBC1 domain family, member 22A Q8WUA7 Nucleus (GO:0005634) 17081983 golgi apparatus 34 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TBC1D22B HGNC:21602 TBC1 domain family, member 22B Q9NU19 golgi apparatus 34 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota TBC1D23 HGNC:25622 TBC1 domain family, member 23 Q9NUY8 cytoplasm 12 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D24 HGNC:29203 TBC1 domain family, member 24 Q9ULP9 Cytoplasm. Note=Partially expressed at the plasma membrane. cytoplasm 100 0 cytoplasm cytoplasm Chordata Eukaryota Eukaryota TBC1D25 HGNC:8092 TBC1 domain family, member 25 Q3MII6 Cytoplasm. Cytoplasmic vesicle, autophagosome. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions. cytoplasm 100 0 cytoplasm cytoplasm Mammalia Bilateria NA TBC1D26 HGNC:28745 TBC1 domain family, member 26 Q86UD7 nucleus 17 0 nucleus nucleus Catarrhini Catarrhini Eukaryota TBC1D28 HGNC:26858 TBC1 domain family, member 28 Q2M2D7 cytoplasm 17 0 cytoplasm cytoplasm Human Human Eukaryota TBC1D29 HGNC:24509 TBC1 domain family, member 29 Q9UFV1 nucleus 33 0 nucleus nucleus Human Human Mammalia TBC1D2B HGNC:29183 TBC1 domain family, member 2B Q9UPU7 cytoplasm 19 1 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota TBC1D3 HGNC:19031 TBC1 domain family, member 3 Q8IZP1 cytoplasm 8 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D30 HGNC:29164 TBC1 domain family, member 30 Q9Y2I9 Cell membrane; Peripheral membrane protein. cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota TBC1D31 HGNC:30888 TBC1 domain family, member 31 Q96DN5 nucleus 6 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms TBC1D32 HGNC:21485 TBC1 domain family, member 32 Q96NH3 Cytoplasm (By similarity). Cell projection, cilium (By similarity). nucleus 81 2 nucleus nucleus Deuterostomia Deuterostomia Opisthokonta TBC1D3B HGNC:27011 TBC1 domain family, member 3B A6NDS4 golgi apparatus 7 0 golgi apparatus golgi apparatus NA NA NA TBC1D3C HGNC:24889 TBC1 domain family, member 3C Q6IPX1 golgi apparatus 7 0 golgi apparatus golgi apparatus NA NA Eukaryota TBC1D3F HGNC:18257 TBC1 domain family, member 3F A6NER0 Plasma membrane (GO:0005886) 12612085 cytoplasm 8 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D3G HGNC:29860 TBC1 domain family, member 3G Q6DHY5 cytoplasm 8 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D3H HGNC:30708 TBC1 domain family, member 3H P0C7X1 cytoplasm 8 0 cytoplasm cytoplasm NA NA Eukaryota TBC1D4 HGNC:19165 TBC1 domain family, member 4 O60343 Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 100 1 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota TBC1D5 HGNC:19166 TBC1 domain family, member 5 Q92609 cytoplasm 17 2 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TBC1D7 HGNC:21066 TBC1 domain family, member 7 Q9P0N9 Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1- TSC2 complex. Cytoplasmic vesicle (GO:0016023) ,17658474, cytoplasm 100 1 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota TBC1D8 HGNC:17791 TBC1 domain family, member 8 (with GRAM domain) O95759 Integral to membrane (GO:0016021) 10373574 cytoplasm 16 2 cytoplasm cytoplasm Eukaryota Cell.Organisms Eukaryota TBC1D8B HGNC:24715 TBC1 domain family, member 8B (with GRAM domain) Q0IIM8 cytoplasm 16 2 cytoplasm cytoplasm Eukaryota Cell.Organisms Eukaryota TBC1D9 HGNC:21710 TBC1 domain family, member 9 (with GRAM domain) Q6ZT07 cytoplasm 18 2 cytoplasm cytoplasm Eukaryota Cell.Organisms Eukaryota TBC1D9B HGNC:29097 TBC1 domain family, member 9B (with GRAM domain) Q66K14 Membrane; Single-pass membrane protein (Potential). cytoplasm 15 2 cytoplasm cytoplasm Eukaryota Cell.Organisms Eukaryota TBCA HGNC:11579 tubulin folding cofactor A O75347 Cytoplasm, cytoskeleton. Cytoskeleton (GO:0005856) cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TBCB HGNC:1989 tubulin folding cofactor B Q99426 Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone. Cytoplasm (GO:0005737) 8978778 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TBCC HGNC:11580 tubulin folding cofactor C Q15814 Cytoplasm. Note=Detected predominantly in the photoreceptor connecting cilium. Cytoplasm (GO:0005737) 8706133 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota TBCCD1 HGNC:25546 TBCC domain containing 1 Q9NVR7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota TBCD HGNC:11581 tubulin folding cofactor D Q9BTW9 Cell junction, tight junction (By similarity). Lateral cell membrane (By similarity). Cytoplasm (By similarity). Cell junction, adherens junction (By similarity). Note=Localized in cell-cell contacts (By similarity). Microtubule (GO:0005874) 10722852 cytoplasm 24 2 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TBCE HGNC:11582 tubulin folding cofactor E Q15813 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) 9891010 cytoplasm 38 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms TBCEL HGNC:28115 tubulin folding cofactor E-like Q5QJ74 Cytoplasm, cytoskeleton (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15728251,15728251 nucleus 20 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TBCK HGNC:28261 TBC1 domain containing kinase Q8TEA7 golgi apparatus 10 3 golgi apparatus golgi apparatus Bilateria Eukaryota Cell.Organisms TBK1 HGNC:11584 TANK-binding kinase 1 Q9UHD2 Cytoplasm. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms TBKBP1 HGNC:30140 TBK1 binding protein 1 A7MCY6 nucleus 30 0 nucleus nucleus Eutheria Euteleostomi Euteleostomi TBL1X HGNC:11585 transducin (beta)-like 1X-linked O60907 Nucleus (Probable). Nucleus (GO:0005634) 10944117 nucleus 76 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms TBL1XR1 HGNC:29529 transducin (beta)-like 1 X-linked receptor 1 Q9BZK7 Nucleus (Probable). Nucleus (GO:0005634) 11931768 nucleus 64 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms TBL1Y HGNC:18502 transducin (beta)-like 1, Y-linked Q9BQ87 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 68 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms TBL2 HGNC:11586 transducin (beta)-like 2 Q9Y4P3 Nucleus (GO:0005634) 10575226 nucleus 10 0 nucleus nucleus Deuterostomia Eukaryota NA TBL3 HGNC:11587 transducin (beta)-like 3 Q12788 Nucleus, nucleolus. Nucleolus (GO:0005730) 15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms TBP HGNC:11588 TATA box binding protein P20226 Nucleus. Nucleus (GO:0005634) 2194289,16023139,7675079 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms TBPL1 HGNC:11589 TBP-like 1 P62380 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9889269,9889269 nucleus 27 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms TBPL2 HGNC:19841 TATA box binding protein like 2 Q6SJ96 Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokenesis. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14634207,14634207 nucleus 84 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms TBR1 HGNC:11590 T-box, brain, 1 Q16650 Nucleus (Potential). Nucleus (GO:0005634) 10749215 nucleus 48 0 nucleus nucleus Theria Euteleostomi Holozoa TBRG1 HGNC:29551 transforming growth factor beta regulator 1 Q3YBR2 Nucleus. Nucleus (GO:0005634) 7654366 nucleus 100 0 nucleus nucleus Mammalia Eukaryota Eukaryota TBRG4 HGNC:17443 transforming growth factor beta regulator 4 Q969Z0 Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15598749,17081983 mitochondrion 41 0 mitochondrion. nucleus multiple Tetrapoda Bilateria Bilateria TBX1 HGNC:11592 T-box 1 O43435 Nucleus (Potential). Nucleus (GO:0005634) 15703190 nucleus 37 0 nucleus nucleus Bilateria Bilateria Holozoa TBX10 HGNC:11593 T-box 10 O75333 Nucleus (Potential). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Bilateria Bilateria Holozoa TBX15 HGNC:11594 T-box 15 Q96SF7 Nucleus (Potential). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Amniota Euteleostomi Holozoa TBX18 HGNC:11595 T-box 18 O95935 Nucleus (Potential). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa TBX19 HGNC:11596 T-box 19 O60806 Nucleus (Potential). Nucleus (GO:0005634) 11290323 nucleus 49 0 nucleus nucleus Deuterostomia Bilateria Holozoa TBX2 HGNC:11597 T-box 2 Q13207 Nucleus (Potential). Nucleus (GO:0005634) nucleus 58 0 nucleus nucleus Bilateria Bilateria Holozoa TBX20 HGNC:11598 T-box 20 Q9UMR3 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14550786,14550786 nucleus 44 0 cytoplasm. nucleus multiple Chordata Bilateria Holozoa TBX21 HGNC:11599 T-box 21 Q9UL17 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Mammalia Mammalia Holozoa TBX22 HGNC:11600 T-box 22 Q9Y458 Nucleus (Potential). Nucleus (GO:0005634) 11024289 nucleus 37 0 nucleus nucleus Tetrapoda Euteleostomi Holozoa TBX3 HGNC:11602 T-box 3 O15119 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 15289316,17081983,17081983/15289316,11689487,12005433 nucleus 62 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Holozoa TBX4 HGNC:11603 T-box 4 P57082 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Amniota Euteleostomi Holozoa TBX5 HGNC:11604 T-box 5 Q99593 Nucleus (Potential). Nucleus (GO:0005634) 15087119 nucleus 50 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa TBX6 HGNC:11605 T-box 6 O95947 Nucleus (Potential). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Mammalia Euteleostomi Holozoa TBXA2R HGNC:11608 thromboxane A2 receptor P21731 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7929844 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Bilateria TBXAS1 HGNC:11609 thromboxane A synthase 1 (platelet) P24557 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576);Endoplasmic reticulum (GO:0005783) 1730669,14718574/1730669 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane. secreted multiple Euteleostomi Eukaryota Cell.Organisms TC2N HGNC:19859 tandem C2 domains, nuclear Q8N9U0 Nucleus (By similarity). Nucleus (GO:0005634) 11526914 nucleus 85 1 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa TCAIM HGNC:25241 T cell activation inhibitor, mitochondrial Q8N3R3 Mitochondrion (By similarity). mitochondrion 79 0 mitochondrion mitochondrion Bilateria Bilateria Eumetazoa TCAP HGNC:11610 titin-cap O15273 Cytoplasm, myofibril, sarcomere. Cytoplasm (GO:0005737) 9350988 cytoplasm 100 0 cytoplasm cytoplasm Theria Euteleostomi Euteleostomi TCEA1 HGNC:11612 transcription elongation factor A (SII), 1 P23193 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 2471707,1708494,15635413,17081983/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TCEA2 HGNC:11614 transcription elongation factor A (SII), 2 Q15560 Nucleus. Nucleoplasm (GO:0005654) 12761297 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Cell.Organisms TCEA3 HGNC:11615 transcription elongation factor A (SII), 3 O75764 Nucleus (By similarity). nucleus 51 0 nucleus nucleus Mammalia Euteleostomi Cell.Organisms TCEAL1 HGNC:11616 transcription elongation factor A (SII)-like 1 Q15170 Nucleus. Nucleus (GO:0005634) 10051408,7971997,17081983 nucleus 100 0 nucleus nucleus Eutheria Eutheria Eutheria TCEAL2 HGNC:29818 transcription elongation factor A (SII)-like 2 Q9H3H9 Nucleus (Probable). Nucleus (GO:0005634) secreted 48 0 nucleus nucleus Human Catarrhini Eutheria TCEAL3 HGNC:28247 transcription elongation factor A (SII)-like 3 Q969E4 Nucleus (Probable). secreted 13 0 nucleus nucleus Euarchontoglires Eutheria Eutheria TCEAL4 HGNC:26121 transcription elongation factor A (SII)-like 4 Q96EI5 Nucleus (Probable). endoplasmic reticulum 29 0 nucleus nucleus Catarrhini Eutheria Eutheria TCEAL5 HGNC:22282 transcription elongation factor A (SII)-like 5 Q5H9L2 Nucleus (Probable). Nucleus (GO:0005634) secreted 13 0 nucleus nucleus Euarchontoglires Eutheria Cell.Organisms TCEAL6 HGNC:24553 transcription elongation factor A (SII)-like 6 Q6IPX3 Nucleus (Probable). secreted 15 0 nucleus nucleus Human Human NA TCEAL7 HGNC:28336 transcription elongation factor A (SII)-like 7 Q9BRU2 Nucleus. nucleus 100 0 nucleus nucleus Homininae Euarchontoglires Eutheria TCEAL8 HGNC:28683 transcription elongation factor A (SII)-like 8 Q8IYN2 Nucleus (Probable). nucleus 41 0 nucleus nucleus Eutheria Eutheria Eutheria TCEANC HGNC:28277 transcription elongation factor A (SII) N-terminal and central domain containing Q8N8B7 nucleus 16 0 nucleus nucleus Eutheria Euteleostomi Eukaryota TCEANC2 HGNC:26494 transcription elongation factor A (SII) N-terminal and central domain containing 2 Q96MN5 Nucleus (By similarity). nucleus 35 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota TCEB1 HGNC:11617 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) Q15369 Nucleus (Probable). Nucleus (GO:0005634) 12943681 nucleus 31 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TCEB2 HGNC:11619 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) Q15370 Nucleus (Probable). Nucleus (GO:0005634) 12943681,7660129 nucleus 41 0 nucleus nucleus Bilateria Bilateria Metazoa TCEB3 HGNC:11620 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) Q14241 Nucleus (Probable). Nucleus (GO:0005634); Nucleolus (GO:0005730) 12943681,19037258,15635413 nucleus 42 0 nucleus nucleus Deuterostomia Eukaryota Opisthokonta TCEB3B HGNC:30771 transcription elongation factor B polypeptide 3B (elongin A2) Q8IYF1 Nucleus (Probable). Nucleus (GO:0005634) 10692460,8244996 nucleus 54 0 nucleus nucleus Human Human Opisthokonta TCEB3C HGNC:24617 transcription elongation factor B polypeptide 3C (elongin A3) Q8NG57 Nucleus. Nucleus (GO:0005634) 11994304 nucleus 100 0 nucleus nucleus Catarrhini Catarrhini Eukaryota TCEB3CL HGNC:31007 transcription elongation factor B polypeptide 3C-like Q3SY89 Nucleus (By similarity). nucleus 100 0 nucleus nucleus NA NA Eukaryota TCEB3CL2 HGNC:33511 transcription elongation factor B polypeptide 3C-like 2 A6NLF2 Nucleus (By similarity). nucleus 99 0 nucleus nucleus NA NA NA TCERG1 HGNC:15630 transcription elongation regulator 1 O14776 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 9315662,11604498,11172033,10908677,15561729,15635413 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota TCERG1L HGNC:23533 transcription elongation regulator 1-like Q5VWI1 Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota TCF12 HGNC:11623 transcription factor 12 Q99081 Nucleus. Nucleus (GO:0005634) 1312219 nucleus 100 0 nucleus nucleus Chordata Bilateria Metazoa TCF15 HGNC:11627 transcription factor 15 (basic helix-loop-helix) Q12870 Nucleus (By similarity). Nucleus (GO:0005634) 8041747 nucleus 40 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa TCF19 HGNC:11629 transcription factor 19 Q9Y242 Nucleus (Potential). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Theria Euteleostomi NA TCF20 HGNC:11631 transcription factor 20 (AR1) Q9UGU0 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10995766/17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Bilateria NA TCF21 HGNC:11632 transcription factor 21 O43680 Nucleus. Nucleus (GO:0005634) 12493738,9545526 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa TCF23 HGNC:18602 transcription factor 23 Q7RTU1 Nucleus (By similarity). Nucleus (GO:0005634) 10652346 nucleus 74 0 nucleus nucleus Mammalia Euteleostomi Bilateria TCF24 HGNC:32275 transcription factor 24 Q7RTU0 Nucleus (By similarity). nucleus 49 0 nucleus nucleus NA NA Eumetazoa TCF25 HGNC:29181 transcription factor 25 (basic helix-loop-helix) Q9BQ70 Nucleus. Note=Some staining in the cytosol. nucleus 100 1 nucleus nucleus Eukaryota Eukaryota Eukaryota TCF3 HGNC:11633 transcription factor 3 P15923 Nucleus. Nucleus (GO:0005634) 12566462,8164688 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Metazoa TCF4 HGNC:11634 transcription factor 4 P15884 Nucleus. Nucleus (GO:0005634); Cytosol (GO:0005829) 1681116,16306047,16724116,12944908,16306047 nucleus 100 0 cytoplasm. nucleus multiple Chordata Bilateria Opisthokonta TCF7 HGNC:11639 transcription factor 7 (T-cell specific, HMG-box) P36402 Nucleus. Nucleus (GO:0005634) 7579399 nucleus 100 0 nucleus nucleus Human Euteleostomi Eukaryota TCF7L1 HGNC:11640 transcription factor 7-like 1 (T-cell specific, HMG-box) Q9HCS4 Nucleus. Nucleus (GO:0005634) 11085512 nucleus 100 0 nucleus nucleus Theria Euteleostomi Opisthokonta TCF7L2 HGNC:11641 transcription factor 7-like 2 (T-cell specific, HMG-box) Q9NQB0 Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies. Nucleus (GO:0005634) 10694436,16569639 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta TCFL5 HGNC:11646 transcription factor-like 5 (basic helix-loop-helix) Q9UL49 Nucleus. Nucleus (GO:0005634) 9763657 nucleus 100 0 nucleus nucleus Amniota Amniota Craniata TCHH HGNC:11791 trichohyalin Q07283 cytoplasm 15 0 cytoplasm cytoplasm Human Eutheria Euteleostomi TCHHL1 HGNC:31796 trichohyalin-like 1 Q5QJ38 cytoplasm 10 0 cytoplasm cytoplasm Theria Theria Euteleostomi TCHP HGNC:28135 trichoplein, keratin filament binding Q9BT92 Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion. nucleus 26 0 cytoplasm. mitochondrion multiple Euteleostomi Deuterostomia Holozoa TCIRG1 HGNC:11647 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 Q13488 Membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021); Brush border (GO:0005903); Cytosol (GO:0005829) 10329006,16415858,15561729 plasma membrane 37 7 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TCL1A HGNC:11648 T-cell leukemia/lymphoma 1A P56279 Cytoplasm (By similarity). Nucleus (By similarity). Microsome. Endoplasmic reticulum. Note=Microsomal fraction. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886); Endosome (GO:0005768) 12009899,12009899,12009899,7987816 nucleus 50 0 cytoplasm. endoplasmic reticulum. endosome. nucleus multiple Euarchontoglires Eutheria Amniota TCL1B HGNC:11649 T-cell leukemia/lymphoma 1B O95988 Nucleus (GO:0005634); Microsome (GO:0005792) 10983986,10983986 nucleus 51 0 nucleus nucleus Euarchontoglires Eutheria Amniota TCN1 HGNC:11652 transcobalamin I (vitamin B12 binding protein, R binder family) P20061 Secreted. Extracellular (GO:0005576) 1176444 secreted 100 0 secreted secreted Catarrhini Chordata Eumetazoa TCN2 HGNC:11653 transcobalamin II P20062 Secreted. Extracellular (GO:0005576) 1708393,14718574 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa TCOF1 HGNC:11654 Treacher Collins-Franceschetti syndrome 1 Q13428 Nucleus, nucleolus. Nucleoplasm (GO:0005654); Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634);Nucleolus (GO:0005730) 9736782,9736782,15635413,11790298,9811939,9736782,9811939,17081983,17081983/9736782,9811939 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Tetrapoda TCP1 HGNC:11655 t-complex 1 P17987 Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829); Microtubule (GO:0005874) 10978337,10978337,16263121,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TCP10 HGNC:11656 t-complex 10 Q12799 nucleus 71 0 nucleus nucleus Catarrhini Catarrhini Mammalia TCP10L HGNC:11657 t-complex 10-like Q8TDR4 Nucleus. Nucleus (GO:0005634) 14586771,15469726 nucleus 100 0 nucleus nucleus NA NA Euteleostomi TCP10L2 HGNC:21254 t-complex 10-like 2 B9ZVM9 nucleus 73 0 nucleus nucleus Catarrhini Catarrhini Mammalia TCP11 HGNC:11658 t-complex 11, testis-specific Q8WWU5 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 9322250 nucleus 10 1 plasma membrane plasma membrane Theria Eukaryota Eukaryota TCP11L1 HGNC:25655 t-complex 11, testis-specific-like 1 Q9NUJ3 nucleus 6 0 nucleus nucleus Euteleostomi Opisthokonta Eukaryota TCP11L2 HGNC:28627 t-complex 11, testis-specific-like 2 Q8N4U5 nucleus 8 0 nucleus nucleus Chordata Chordata Eukaryota TCP11X1 HGNC:48369 t-complex 11 family, X-linked 1 B4DZS4 nucleus 10 0 nucleus nucleus NA NA Eukaryota TCP11X2 HGNC:48335 t-complex 11 family, X-linked 2 Q5H9J9 nucleus 14 0 nucleus nucleus NA NA Eukaryota TCTA HGNC:11692 T-cell leukemia translocation altered P57738 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 84 1 secreted secreted Theria Euteleostomi Craniata TCTE1 HGNC:11693 t-complex-associated-testis-expressed 1 Q5JU00 cytoplasm 20 0 cytoplasm cytoplasm Tetrapoda Eukaryota Cell.Organisms TCTE3 HGNC:11695 t-complex-associated-testis-expressed 3 Q8IZS6 Cytoplasm, cytoskeleton (Probable). Cytoplasmic granule (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis (By similarity). cytoplasm 3 0 cytoplasm cytoplasm Amniota Chordata Eukaryota TCTEX1D1 HGNC:26882 Tctex1 domain containing 1 Q8N7M0 secreted 10 0 secreted secreted Deuterostomia Deuterostomia Eukaryota TCTEX1D2 HGNC:28482 Tctex1 domain containing 2 Q8WW35 secreted 16 0 secreted secreted Bilateria Eukaryota Eukaryota TCTEX1D4 HGNC:32315 Tctex1 domain containing 4 Q5JR98 Nucleus (GO:0005634); Vesicle (None); Microtubule (GO:0005874); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 16982625,16982625,16982625,16982625,16982625 cytoplasm 12 0 cytoplasm. nucleus multiple Tetrapoda Eukaryota Eukaryota TCTN1 HGNC:26113 tectonic family member 1 Q2MV58 Cytoplasm, cytoskeleton, cilium basal body (By similarity). Secreted (Potential). Note=Despite the presence of a signal sequence, the full length protein might not be secreted (By similarity). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). secreted 92 0 secreted secreted Tetrapoda Eukaryota Opisthokonta TCTN2 HGNC:25774 tectonic family member 2 Q96GX1 Membrane; Single-pass type I membrane protein (Potential). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). secreted 33 1 secreted secreted Euteleostomi Euteleostomi Opisthokonta TCTN3 HGNC:24519 tectonic family member 3 Q6NUS6 Membrane; Single-pass type I membrane protein (Potential). secreted 44 1 secreted secreted Mammalia Eukaryota Eukaryota TDG HGNC:11700 thymine-DNA glycosylase Q13569 Nucleus. Nucleus (GO:0005634) 8662714 nucleus 100 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms TDGF1 HGNC:11701 teratocarcinoma-derived growth factor 1 P13385 Cell membrane; Lipid-anchor, GPI-anchor. Extracellular (GO:0005576) 9876177 secreted 38 1 secreted secreted NA NA Bilateria TDO2 HGNC:11708 tryptophan 2,3-dioxygenase P48775 Cytoplasm (GO:0005737) 11469796 nucleus 57 0 cytoplasm cytoplasm Bilateria Cell.Organisms NA TDP1 HGNC:18884 tyrosyl-DNA phosphodiesterase 1 Q9NUW8 Nucleus. Cytoplasm. Nucleus (GO:0005634) 12023295,15494395,15647511,17081983 nucleus 18 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota TDP2 HGNC:17768 tyrosyl-DNA phosphodiesterase 2 O95551 Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. Nucleus (GO:0005634) secreted 29 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms TDRD1 HGNC:11712 tudor domain containing 1 Q9BXT4 Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity). Also present in chromatoid body (By similarity). cytoplasm 65 0 cytoplasm cytoplasm Amniota Bilateria Eukaryota TDRD10 HGNC:25316 tudor domain containing 10 Q5VZ19 nucleus 23 0 nucleus nucleus Catarrhini Tetrapoda Eukaryota TDRD12 HGNC:25044 tudor domain containing 12 Q587J7 nucleus 4 0 nucleus nucleus Tetrapoda Chordata Cell.Organisms TDRD15 HGNC:45037 tudor domain containing 15 B5MCY1 cytoplasm 13 2 cytoplasm cytoplasm NA NA Opisthokonta TDRD3 HGNC:20612 tudor domain containing 3 Q9H7E2 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules. nucleus 22 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota TDRD5 HGNC:20614 tudor domain containing 5 Q8NAT2 Cytoplasm (By similarity). Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis (By similarity). cytoplasm 75 0 cytoplasm cytoplasm Deuterostomia Bilateria Opisthokonta TDRD6 HGNC:21339 tudor domain containing 6 O60522 Cytoplasm (By similarity). Note=Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity). cytoplasm 66 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota TDRD7 HGNC:30831 tudor domain containing 7 Q8NHU6 Cytoplasm. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity). Mitochondrion (GO:0005739); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10727952,11527406,11527406 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Bilateria Opisthokonta TDRD9 HGNC:20122 tudor domain containing 9 Q8NDG6 Cytoplasm (By similarity). Nucleus (By similarity). Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies (By similarity). cytoplasm 21 2 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms TDRKH HGNC:11713 tudor and KH domain containing Q9Y2W6 Cytoplasm (By similarity). Mitochondrion (By similarity). Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Co-localizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline (By similarity). nucleus 19 1 nucleus nucleus Euteleostomi Bilateria Eukaryota TDRP HGNC:26951 testis development related protein Q86YL5 Nucleus. Cytoplasm. nucleus 68 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Tetrapoda TEAD1 HGNC:11714 TEA domain family member 1 (SV40 transcriptional enhancer factor) P28347 Nucleus. Nucleus (GO:0005634) 12565854,12861002 nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta TEAD2 HGNC:11715 TEA domain family member 2 Q15562 Nucleus. Nucleus (GO:0005634) 12642588 nucleus 100 0 nucleus nucleus Eutheria Eutheria Opisthokonta TEAD3 HGNC:11716 TEA domain family member 3 Q99594 Nucleus. Nucleus (GO:0005634) 11986313 nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta TEAD4 HGNC:11717 TEA domain family member 4 Q15561 Nucleus. Nucleus (GO:0005634) 11358867 nucleus 100 0 nucleus nucleus Bilateria Bilateria Opisthokonta TEC HGNC:11719 tec protein tyrosine kinase P42680 Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). Cytoplasm (GO:0005737) 7526158 cytoplasm 49 0 cytoplasm cytoplasm Chordata Bilateria Cell.Organisms TECPR1 HGNC:22214 tectonin beta-propeller repeat containing 1 Q7Z6L1 Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes. secreted 17 0 secreted secreted Bilateria Bilateria Eukaryota TECPR2 HGNC:19957 tectonin beta-propeller repeat containing 2 O15040 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa TECR HGNC:4551 trans-2,3-enoyl-CoA reductase Q9NZ01 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 12482854,15598749 endoplasmic reticulum membrane 100 6 endoplasmic reticulum. endoplasmic reticulum membrane. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms TECRL HGNC:27365 trans-2,3-enoyl-CoA reductase-like Q5HYJ1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 40 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Eukaryota TECTA HGNC:11720 tectorin alpha O75443 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (Probable). Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane (By similarity). Extracellular (GO:0005576) 9590290 secreted 20 1 secreted secreted Deuterostomia Bilateria Cell.Organisms TECTB HGNC:11721 tectorin beta Q96PL2 Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (Probable). Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane (By similarity). Extracellular (GO:0005576) 9079715 plasma membrane 24 1 secreted secreted Euteleostomi Euteleostomi Eumetazoa TEDDM1 HGNC:30233 transmembrane epididymal protein 1 Q5T9Z0 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 53 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eutheria Bilateria TEF HGNC:11722 thyrotrophic embryonic factor Q10587 Nucleus. Nucleus (GO:0005634) 9891058 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Holozoa TEFM HGNC:26223 transcription elongation factor, mitochondrial Q96QE5 Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid. mitochondrion 100 1 mitochondrion mitochondrion Deuterostomia Bilateria Eumetazoa TEK HGNC:11724 TEK tyrosine kinase, endothelial Q02763 Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Note=Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted. Plasma membrane (GO:0005886) 8382358 plasma membrane 34 1 cytoplasm. plasma membrane. secreted multiple Deuterostomia Deuterostomia Cell.Organisms TEKT1 HGNC:15534 tektin 1 Q969V4 Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoskeleton (GO:0005856); Microtubule (GO:0005874) ,15561729 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota TEKT2 HGNC:11725 tektin 2 (testicular) Q9UIF3 Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In sperm, observed in a discontinuous punctate pattern in the flagellum and in the postacrosomal head region. Cell projection (GO:0042995) 15340058 cytoplasm 80 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa TEKT3 HGNC:14293 tektin 3 Q9BXF9 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Cytoskeleton (GO:0005856); Centrosome (GO:0005813) 14735490,14735490 cytoplasm 22 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TEKT4 HGNC:31012 tektin 4 Q8WW24 Cell projection, cilium, flagellum (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella (By similarity). cytoplasm 24 0 cytoplasm cytoplasm Deuterostomia Deuterostomia NA TEKT5 HGNC:26554 tektin 5 Q96M29 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, flagellum axoneme (By similarity). Cytoskeleton (GO:0005856) cytoplasm 20 0 cytoplasm cytoplasm Amniota Amniota Eukaryota TELO2 HGNC:29099 telomere maintenance 2 Q9Y4R8 Cytoplasm. Membrane. Nucleus. Chromosome, telomere (Probable). cytoplasm 6 2 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota TEN1 HGNC:37242 TEN1 CST complex subunit Q86WV5 Nucleus. Chromosome, telomere. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Bilateria TENC1 HGNC:19737 tensin like C1 domain containing phosphatase (tensin 2) Q63HR2 Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the end of actin stress fibers. Actin filament (GO:0005884); Cytoplasm (GO:0005737) 11792844,17081983 secreted 38 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota TENM1 HGNC:8117 teneurin transmembrane protein 1 Q9UKZ4 Cell membrane; Single-pass membrane protein (By similarity). Ten-1 intracellular domain: Nucleus (By similarity). Nucleus speckle (By similarity). Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity). Teneurin C-terminal-associated peptide: Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). Plasma membrane (GO:0005886) 12915301 golgi apparatus membrane 26 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms TENM2 HGNC:29943 teneurin transmembrane protein 2 Q9NT68 Cell membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Cell junction, synapse (By similarity). Cell projection, dendritic spine (By similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Isoform 2: Cell membrane. Ten-2 intracellular domain: Nucleus, PML body (By similarity). secreted 25 1 secreted secreted Bilateria Bilateria Cell.Organisms TENM3 HGNC:29944 teneurin transmembrane protein 3 Q9P273 Membrane; Single-pass membrane protein (Probable). Cell projection, axon (By similarity). Plasma membrane (GO:0005886) 12000766 secreted 23 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms TENM4 HGNC:29945 teneurin transmembrane protein 4 Q6N022 Membrane; Single-pass membrane protein (Probable). Nucleus (By similarity). Cytoplasm (By similarity). Cell projection (By similarity). secreted 28 1 secreted secreted Bilateria Bilateria Cell.Organisms TEP1 HGNC:11726 telomerase-associated protein 1 Q99973 Nucleus (Probable). Chromosome, telomere. Nucleus (GO:0005634) cytoplasm 8 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms TEPP HGNC:33745 testis, prostate and placenta expressed Q6URK8 Secreted (Potential). nucleus 32 0 nucleus nucleus Mammalia Deuterostomia Metazoa TERF1 HGNC:11728 telomeric repeat binding factor (NIMA-interacting) 1 P54274 Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7502076,12135354,17081983,12667345 nucleus 35 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota TERF2 HGNC:11729 telomeric repeat binding factor 2 Q15554 Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase. Nucleus (GO:0005634) 10888888,17081983 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota TERF2IP HGNC:19246 telomeric repeat binding factor 2, interacting protein Q9NYB0 Nucleus. Cytoplasm (By similarity). Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). Nucleus (GO:0005634) 15100233,17081983 nucleus 35 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta TERT HGNC:11730 telomerase reverse transcriptase O14746 Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress- mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12937127,12808100,12594176,15569357,15138842,12198499,10835362,15190070,17237767,12937127,12808100,15138842,10835362,12083802,15138842,12198499,15569357 nucleus 11 2 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota TES HGNC:14620 testis derived transcript (3 LIM domains) Q9UGI8 Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 9045675,9045675 cytoplasm 18 0 cytoplasm. secreted multiple Chordata Bilateria Eukaryota TESC HGNC:26065 tescalcin Q96BS2 Nucleus. Cytoplasm. Membrane (By similarity). Cell membrane. Cell projection, lamellipodium (By similarity). Cell projection, ruffle membrane (By similarity). Note=Colocalizes with SLC9A1 at the plasma membrane. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14661968,11696366,14661968 cytoplasm 77 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota TESK1 HGNC:11731 testis-specific kinase 1 Q15569 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11418599,11555644,11555644 nucleus 50 0 cytoplasm cytoplasm Mammalia Mammalia Cell.Organisms TESK2 HGNC:11732 testis-specific kinase 2 Q96S53 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11418599,11418599 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms TESPA1 HGNC:29109 thymocyte expressed, positive selection associated 1 A2RU30 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eutheria Euteleostomi Bilateria TET1 HGNC:29484 tet methylcytosine dioxygenase 1 Q8NFU7 Nucleus (Probable). Nucleus (GO:0005634) 12124344 cytoplasm 59 0 nucleus nucleus Amniota Euteleostomi Metazoa TET2 HGNC:25941 tet methylcytosine dioxygenase 2 Q6N021 nucleus 49 0 nucleus nucleus Chordata Bilateria Metazoa TET3 HGNC:28313 tet methylcytosine dioxygenase 3 O43151 Nucleus (By similarity). Cytoplasm (By similarity). Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages (By similarity). nucleus 40 0 nucleus nucleus Euteleostomi Deuterostomia Metazoa TEX10 HGNC:25988 testis expressed 10 Q9NXF1 Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). nucleus 18 3 nucleus. nucleus membrane multiple Deuterostomia Eukaryota Eukaryota TEX101 HGNC:30722 testis expressed 101 Q9BY14 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Note=Associated with lipid rafts (By similarity). secreted 93 0 secreted secreted Eutheria Eutheria Mammalia TEX11 HGNC:11733 testis expressed 11 Q8IYF3 Chromosome (By similarity). Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes (By similarity). nucleus 45 0 nucleus nucleus Theria Eukaryota Eukaryota TEX12 HGNC:11734 testis expressed 12 Q9BXU0 nucleus 37 0 nucleus nucleus Theria Theria Mammalia TEX13A HGNC:11735 testis expressed 13A Q9BXU3 nucleus 51 0 nucleus nucleus Eutheria Eutheria Opisthokonta TEX13B HGNC:11736 testis expressed 13B Q9BXU2 nucleus 35 0 nucleus nucleus Eutheria Eutheria Eutheria TEX14 HGNC:11737 testis expressed 14 Q8IWB6 Cytoplasm (By similarity). Midbody (By similarity). Chromosome, centromere, kinetochore (By similarity). Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division (By similarity). Nucleus (GO:0005634) 12711554 plasma membrane 7 0 nucleus nucleus Amniota Amniota Cell.Organisms TEX15 HGNC:11738 testis expressed 15 Q9BXT5 nucleus 93 0 nucleus nucleus Mammalia Mammalia Craniata TEX19 HGNC:33802 testis expressed 19 Q8NA77 Nucleus (By similarity). nucleus 49 0 nucleus nucleus Euarchontoglires Eutheria Boreoeutheria TEX2 HGNC:30884 testis expressed 2 Q8IWB9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 18 2 nucleus nucleus Bilateria Bilateria NA TEX22 HGNC:40026 testis expressed 22 C9J3V5 Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). nucleus 38 0 nucleus nucleus NA NA NA TEX26 HGNC:28622 testis expressed 26 Q8N6G2 nucleus 38 0 nucleus nucleus Mammalia Chordata Bilateria TEX261 HGNC:30712 testis expressed 261 Q6UWH6 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 28 5 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota NA TEX264 HGNC:30247 testis expressed 264 Q9Y6I9 Secreted (Potential). Extracellular (GO:0005576) 12975309 plasma membrane 63 0 secreted secreted Amniota Cell.Organisms Metazoa TEX28 HGNC:2563 testis expressed 28 O15482 Membrane; Single-pass membrane protein (Potential). secreted 33 2 n/a n/a Eutheria Mammalia Bilateria TEX29 HGNC:20370 testis expressed 29 Q8N6K0 Membrane; Single-pass membrane protein (Potential). nucleus 35 1 nucleus nucleus Eutheria Eutheria Eutheria TEX30 HGNC:25188 testis expressed 30 Q5JUR7 mitochondrion 10 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms TEX33 HGNC:28568 testis expressed 33 O43247 nucleus 54 0 nucleus nucleus Amniota Amniota Bilateria TEX35 HGNC:25366 testis expressed 35 Q5T0J7 nucleus 52 0 nucleus nucleus NA NA Eutheria TEX36 HGNC:31653 testis expressed 36 Q5VZQ5 nucleus 16 0 nucleus nucleus Eutheria Deuterostomia Bilateria TEX37 HGNC:26341 testis expressed 37 Q96LM6 Nucleus (By similarity). nucleus 62 0 nucleus nucleus Eutheria Eutheria Eutheria TEX38 HGNC:29589 testis expressed 38 Q6PEX7 Membrane; Single-pass membrane protein (Potential). secreted 54 1 secreted secreted Theria Theria Mammalia TEX40 HGNC:19231 testis expressed 40 Q9NTU4 nucleus 81 0 nucleus nucleus Homininae Eutheria Boreoeutheria TEX43 HGNC:33767 testis expressed 43 Q6ZNM6 nucleus 30 0 nucleus nucleus Theria Deuterostomia Eumetazoa TEX9 HGNC:29585 testis expressed 9 Q8N6V9 nucleus 14 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota TF HGNC:11740 transferrin P02787 Secreted. Endosome (GO:0005768); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 17196367,16530040,11297622,11297622,11297622,9312001,10931525,16199891,16188874 secreted 100 0 cytoplasm. endoplasmic reticulum. endosome. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota TFAM HGNC:11741 transcription factor A, mitochondrial Q00059 Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 9063738,9063738 mitochondrion 100 0 mitochondrion. nucleus multiple Chordata Eukaryota Eukaryota TFAP2A HGNC:11742 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) P05549 Nucleus. Nucleus (GO:0005634) 8321221 nucleus 100 0 nucleus nucleus Chordata Bilateria Metazoa TFAP2B HGNC:11743 transcription factor AP-2 beta (activating enhancer binding protein 2 beta) Q92481 Nucleus (Probable). Nucleus (GO:0005634) 11278660 nucleus 71 0 nucleus nucleus Tetrapoda Deuterostomia Metazoa TFAP2C HGNC:11744 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) Q92754 Nucleus (Probable). Nucleus (GO:0005634) 11095974,9113991 nucleus 58 0 nucleus nucleus Euteleostomi Bilateria Metazoa TFAP2D HGNC:15581 transcription factor AP-2 delta (activating enhancer binding protein 2 delta) Q7Z6R9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Amniota Euteleostomi Metazoa TFAP2E HGNC:30774 transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) Q6VUC0 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 92 1 nucleus nucleus Euteleostomi Euteleostomi Metazoa TFAP4 HGNC:11745 transcription factor AP-4 (activating enhancer binding protein 4) Q01664 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta TFB1M HGNC:17037 transcription factor B1, mitochondrial Q8WVM0 Mitochondrion. Mitochondrion (GO:0005739) 11809803 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms TFB2M HGNC:18559 transcription factor B2, mitochondrial Q9H5Q4 Mitochondrion. Mitochondrion (GO:0005739) 12068295,15598749 mitochondrion 100 0 mitochondrion mitochondrion Amniota Deuterostomia Cell.Organisms TFCP2 HGNC:11748 transcription factor CP2 Q12800 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8157699,9685356 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Opisthokonta TFCP2L1 HGNC:17925 transcription factor CP2-like 1 Q9NZI6 Nucleus. Nucleus (GO:0005634) 1173954,10644752,15471945 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta TFDP1 HGNC:11749 transcription factor Dp-1 Q14186 Nucleus. Nucleus (GO:0005634) 8832394 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota TFDP2 HGNC:11751 transcription factor Dp-2 (E2F dimerization partner 2) Q14188 Nucleus. Nucleus (GO:0005634) 12927774 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota TFDP3 HGNC:24603 transcription factor Dp family, member 3 Q5H9I0 Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members. Nucleus (GO:0005634) 12097419 nucleus 72 0 cytoplasm. nucleus multiple Human Catarrhini Eukaryota TFE3 HGNC:11752 transcription factor binding to IGHM enhancer 3 P19532 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1685140,10644981,17081983,10644981,17081983 nucleus 100 0 cytoplasm. nucleus multiple Chordata Chordata NA TFEB HGNC:11753 transcription factor EB P19484 Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus. Nucleus (GO:0005634) 8530024 nucleus 67 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota TFEC HGNC:11754 transcription factor EC O14948 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta TFF1 HGNC:11755 trefoil factor 1 P04155 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 3041593,10673290,12034770,10673290 secreted 100 0 cytoplasm. secreted multiple Theria Tetrapoda Holozoa TFF2 HGNC:11756 trefoil factor 2 Q03403 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 9781055,10716671,12717829 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Chordata Opisthokonta TFF3 HGNC:11757 trefoil factor 3 (intestinal) Q07654 Secreted, extracellular space, extracellular matrix, apical lamina. Extracellular (GO:0005576) 8454642,9070946,8346203 secreted 100 0 secreted secreted Theria Tetrapoda Eumetazoa TFG HGNC:11758 TRK-fused gene Q92734 Cytoplasm (GO:0005737) 7565764,15557341 cytoplasm 26 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Opisthokonta TFIP11 HGNC:17165 tuftelin interacting protein 11 Q9UBB9 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 17081983/10806191,10806191,10806191 nucleus 22 0 cytoplasm. nucleus. secreted multiple Opisthokonta Eukaryota Eukaryota TFPI HGNC:11760 tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) P10646 Isoform Alpha: Secreted. Isoform Beta: Microsome membrane; Lipid- anchor, GPI-anchor. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11166776,10856975,15817451,10996745,15817451 secreted 92 0 cytoplasm. secreted multiple Chordata Eukaryota Cell.Organisms TFPI2 HGNC:11761 tissue factor pathway inhibitor 2 P48307 Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 8914837,9445254,11834519,11945080,11834519,11945080 secreted 100 0 endoplasmic reticulum. secreted multiple Euteleostomi Euteleostomi Cell.Organisms TFPT HGNC:13630 TCF3 (E2A) fusion partner (in childhood Leukemia) P0C1Z6 Nucleus. Nucleus (GO:0005634); Chromosome (GO:0005694) 10644725,17395368,16230350 nucleus 100 0 nucleus nucleus Mammalia Bilateria NA TFR2 HGNC:11762 transferrin receptor 2 Q9UP52 Cell membrane; Single-pass type II membrane protein. Isoform Beta: Cytoplasm (Probable). Note=Lacks the transmembrane domain. Probably intracellular. Plasma membrane (GO:0005886) 10409623 plasma membrane 17 1 cytoplasm. plasma membrane multiple Theria Theria Cell.Organisms TFRC HGNC:11763 transferrin receptor P02786 Cell membrane; Single-pass type II membrane protein. Melanosome. Transferrin receptor protein 1, serum form: Secreted. Plasma membrane (GO:0005886); Endosome (GO:0005768); Extracellular (GO:0005576); Mitochondrion (GO:0005739); Integral to membrane (GO:0016021); Nucleus (GO:0005634) 6309000,6090955,9120267,17351151,2229063,1871153,15598749,15561729,17081983 plasma membrane 13 1 endosome. melanosome. mitochondrion. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi Cell.Organisms TG HGNC:11764 thyroglobulin P01266 Secreted. Endoplasmic reticulum (GO:0005783); Extracellular (GO:0005576) 10199792,12679418 secreted 100 0 endoplasmic reticulum. secreted multiple Euteleostomi Euteleostomi Cell.Organisms TGDS HGNC:20324 TDP-glucose 4,6-dehydratase O95455 endoplasmic reticulum membrane 12 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Cell.Organisms Cell.Organisms TGFA HGNC:11765 transforming growth factor, alpha P01135 Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 3855503,10230395,9285829,9285829,10230395 plasma membrane 19 1 cytoplasm. endoplasmic reticulum. nucleus. plasma membrane. secreted multiple Euteleostomi Euteleostomi NA TGFB1 HGNC:11766 transforming growth factor, beta 1 P01137 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 11604083 secreted 100 0 secreted secreted Theria Euteleostomi Metazoa TGFB1I1 HGNC:11767 transforming growth factor beta 1 induced transcript 1 O43294 Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers. Nucleus (GO:0005634);Microtubule (GO:0005874) 9032249/,18029348, cytoplasm 18 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota TGFB2 HGNC:11768 transforming growth factor, beta 2 P61812 Secreted. Extracellular (GO:0005576) 11241554 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Metazoa TGFB3 HGNC:11769 transforming growth factor, beta 3 P10600 Secreted. Extracellular (GO:0005576) 8886879 secreted 100 0 secreted secreted Amniota Euteleostomi Metazoa TGFBI HGNC:11771 transforming growth factor, beta-induced, 68kDa Q15582 Secreted, extracellular space, extracellular matrix. Note=May be associated both with microfibrils and with the cell surface. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8077289,10967553,10967553 secreted 100 0 cytoplasm. nucleus. secreted multiple Tetrapoda Cell.Organisms Cell.Organisms TGFBR1 HGNC:11772 transforming growth factor, beta receptor 1 P36897 Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Plasma membrane (GO:0005886) 12017275,15148321 plasma membrane 18 1 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms TGFBR2 HGNC:11773 transforming growth factor, beta receptor II (70/80kDa) P37173 Cell membrane; Single-pass type I membrane protein. Nucleus (GO:0005634);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular matrix (GO:0005578) 17081983/10207840,11157754,12017275,12729750,10207840,10207840 plasma membrane 100 1 cytoplasm. nucleus. plasma membrane. secreted multiple Human Deuterostomia Cell.Organisms TGFBR3 HGNC:11774 transforming growth factor, beta receptor III Q03167 Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein (Potential). Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 10207840,10207840 nucleus 8 1 cytoplasm. plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa TGFBR3L HGNC:44152 transforming growth factor, beta receptor III-like H3BV60 Membrane; Single-pass membrane protein (Potential). plasma membrane 35 1 plasma membrane plasma membrane NA NA Euteleostomi TGFBRAP1 HGNC:16836 transforming growth factor, beta receptor associated protein 1 Q8WUH2 Cytoplasm. Note=Colocalizes with TGF-beta receptors in the absence of signaling. Cytoplasm (GO:0005737) 11278302 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota TGIF1 HGNC:11776 TGFB-induced factor homeobox 1 Q15583 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota TGIF2 HGNC:15764 TGFB-induced factor homeobox 2 Q9GZN2 Nucleus. Note=Excluded from nucleoli. Nucleus (GO:0005634) 11006116 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota TGIF2LX HGNC:18570 TGFB-induced factor homeobox 2-like, X-linked Q8IUE1 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Catarrhini Eutheria Eukaryota TGIF2LY HGNC:18569 TGFB-induced factor homeobox 2-like, Y-linked Q8IUE0 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Human Human Eukaryota TGM1 HGNC:11777 transglutaminase 1 P22735 Membrane; Lipid-anchor. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 12100179,16188874 cytoplasm 23 0 cytoplasm. secreted multiple Deuterostomia Bilateria Eukaryota TGM2 HGNC:11778 transglutaminase 2 P21980 Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12368090,12368090,10521459,10518533,10100610,10100610 cytoplasm 30 0 cytoplasm. nucleus. secreted multiple Euteleostomi Euteleostomi Eukaryota TGM3 HGNC:11779 transglutaminase 3 Q08188 Cytoplasm (GO:0005737); Extracellular (GO:0005576) ,16188874 cytoplasm 33 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota TGM4 HGNC:11780 transglutaminase 4 P49221 Extracellular (GO:0005576) 9721214 secreted 43 0 secreted secreted Deuterostomia Bilateria Eukaryota TGM5 HGNC:11781 transglutaminase 5 O43548 Cytoplasm. Note=Associated with intermediate filaments. Cytoplasm (GO:0005737) cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota TGM6 HGNC:16255 transglutaminase 6 O95932 cytoplasm 34 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota TGM7 HGNC:30790 transglutaminase 7 Q96PF1 cytoplasm 39 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Eukaryota TGOLN2 HGNC:15450 trans-golgi network protein 2 O43493 Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single- pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endosome (GO:0005768); Nucleus (GO:0005634) 9422759,8907712,8907712,9422759,8907712,17081983 nucleus 16 1 endosome. golgi apparatus. golgi apparatus membrane. nucleus. plasma membrane multiple Eutheria Euteleostomi Eukaryota TGS1 HGNC:17843 trimethylguanosine synthase 1 Q96RS0 Cytoplasm. Nucleus, Cajal body. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11517327,11912212,12943661 nucleus 23 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TH HGNC:11782 tyrosine hydroxylase P07101 Cytoplasm (GO:0005737) 11943812 cytoplasm 35 0 cytoplasm cytoplasm Human Cell.Organisms Cell.Organisms THADA HGNC:19217 thyroid adenoma associated Q6YHU6 cytoplasm 15 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota THAP1 HGNC:20856 THAP domain containing, apoptosis associated protein 1 Q9NVV9 Nucleus, nucleoplasm. Nucleus, PML body. Nucleus (GO:0005634) 12717420,12575992 nucleus 100 0 nucleus nucleus Human Chordata Metazoa THAP10 HGNC:23193 THAP domain containing 10 Q9P2Z0 Nucleus (GO:0005634) 12575992,17081983 secreted 33 0 nucleus nucleus Catarrhini Chordata Metazoa THAP11 HGNC:23194 THAP domain containing 11 Q96EK4 Nucleus. Cytoplasm (By similarity). Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus (By similarity). Nucleus (GO:0005634) cytoplasm 22 0 nucleus nucleus Mammalia Euteleostomi Metazoa THAP2 HGNC:20854 THAP domain containing, apoptosis associated protein 2 Q9H0W7 Nucleolus (GO:0005730) 16381901 nucleus 28 0 nucleus nucleus Eutheria Eutheria Metazoa THAP3 HGNC:20855 THAP domain containing, apoptosis associated protein 3 Q8WTV1 nucleus 35 0 nucleus nucleus Theria Euteleostomi Metazoa THAP4 HGNC:23187 THAP domain containing 4 Q8WY91 nucleus 44 0 nucleus nucleus Mammalia Cell.Organisms Cell.Organisms THAP5 HGNC:23188 THAP domain containing 5 Q7Z6K1 Nucleus. Nucleus (GO:0005634) 12575992 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Metazoa THAP6 HGNC:23189 THAP domain containing 6 Q8TBB0 Nucleus (GO:0005634) 12575992 nucleus 25 0 nucleus nucleus Eutheria Chordata Metazoa THAP7 HGNC:23190 THAP domain containing 7 Q9BT49 Nucleus. Chromosome. Nucleus (GO:0005634) 15561719 nucleus 100 0 nucleus nucleus Euarchontoglires Euteleostomi Metazoa THAP8 HGNC:23191 THAP domain containing 8 Q8NA92 Nucleus (GO:0005634) 12575992 nucleus 28 0 nucleus nucleus Catarrhini Eutheria Metazoa THAP9 HGNC:23192 THAP domain containing 9 Q9H5L6 Nucleus (GO:0005634) 12575992 nucleus 32 0 nucleus nucleus Bilateria Bilateria Metazoa THBD HGNC:11784 thrombomodulin P07204 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 3001144,3001144 secreted 22 1 plasma membrane. secreted multiple Amniota Euteleostomi Eukaryota THBS1 HGNC:11785 thrombospondin 1 P07996 Extracellular (GO:0005576) 8751720,16188874 secreted 48 0 secreted secreted Deuterostomia Bilateria Cell.Organisms THBS2 HGNC:11786 thrombospondin 2 P35442 Extracellular (GO:0005576) 11147677 secreted 49 0 secreted secreted Deuterostomia Bilateria Cell.Organisms THBS3 HGNC:11787 thrombospondin 3 P49746 Extracellular (GO:0005576) 10527891 secreted 59 0 secreted secreted Deuterostomia Bilateria Cell.Organisms THBS4 HGNC:11788 thrombospondin 4 P35443 Extracellular (GO:0005576) 10501972 secreted 64 0 secreted secreted Deuterostomia Bilateria Cell.Organisms THEG HGNC:13706 theg spermatid protein Q9P2T0 Nucleus (By similarity). Note=Localized predominantly in the nucleus of haploid round spermatid (By similarity). Nucleus (GO:0005634) 11173852 nucleus 63 0 nucleus nucleus Mammalia Deuterostomia Metazoa THEGL HGNC:43771 theg spermatid protein-like P0DJG4 nucleus 22 0 nucleus nucleus NA NA Metazoa THEM4 HGNC:17947 thioesterase superfamily member 4 Q5T1C6 Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. Plasma membrane (GO:0005886); Cytosol (GO:0005829) 11598301,11598301 mitochondrion 26 0 cytoplasm. mitochondrion multiple Human Cell.Organisms Cell.Organisms THEM5 HGNC:26755 thioesterase superfamily member 5 Q8N1Q8 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Mammalia Mammalia Cell.Organisms THEM6 HGNC:29656 thioesterase superfamily member 6 Q8WUY1 Secreted (Potential). Integral to membrane (GO:0016021) secreted 67 0 secreted secreted Theria Bilateria NA THEMIS HGNC:21569 thymocyte selection associated Q8N1K5 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 62 0 nucleus nucleus Tetrapoda Euteleostomi Bilateria THEMIS2 HGNC:16839 thymocyte selection associated family member 2 Q5TEJ8 nucleus 74 0 nucleus nucleus Amniota Euteleostomi Craniata THG1L HGNC:26053 tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) Q9NWX6 Cytoplasm. Note=Found near the nuclear membrane. Cytoplasm (GO:0005737); Centrosome (GO:0005813); Nucleus (GO:0005634) 15459185,15459185,15459185 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms THNSL1 HGNC:26160 threonine synthase-like 1 (S. cerevisiae) Q8IYQ7 mitochondrion 15 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms THNSL2 HGNC:25602 threonine synthase-like 2 (S. cerevisiae) Q86YJ6 Isoform SOLAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway. secreted 100 0 secreted secreted Cell.Organisms Cell.Organisms Cell.Organisms THOC1 HGNC:19070 THO complex 1 Q96FV9 Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Isoform 2: Cytoplasm. Nucleus (GO:0005634) 7525595,9560268 nucleus 61 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota THOC2 HGNC:19073 THO complex 2 Q8NI27 Nucleus (Probable). Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) none,17081983,15598749,17081983 nucleus 16 0 cytoplasm. mitochondrion. nucleus multiple Opisthokonta Eukaryota Eukaryota THOC3 HGNC:19072 THO complex 3 Q96J01 Nucleus (Probable). Nucleus (GO:0005634) nucleus 8 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms THOC5 HGNC:19074 THO complex 5 Q13769 Nucleus. Cytoplasm (By similarity). Note=Shuttles between nucleus and cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15221008,19059247,15221008,17081983 cytoplasm 8 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota THOC6 HGNC:28369 THO complex 6 homolog (Drosophila) Q86W42 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms THOC7 HGNC:29874 THO complex 7 homolog (Drosophila) Q6I9Y2 Cytoplasm. Nucleus. Note=Interaction with THOC5 is required for nuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12951069,19059247,12951069,19059247 nucleus 48 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota THOP1 HGNC:11793 thimet oligopeptidase 1 P52888 Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 12502762,12648459,11479311,10541437,10415366 cytoplasm 100 0 cytoplasm. secreted multiple Eukaryota Cell.Organisms Cell.Organisms THPO HGNC:11795 thrombopoietin P40225 Secreted. Extracellular (GO:0005576) 9766811 secreted 100 0 secreted secreted Theria Amniota Amniota THRA HGNC:11796 thyroid hormone receptor, alpha P10827 Nucleus. Nucleus (GO:0005634) 11889175 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Metazoa THRAP3 HGNC:22964 thyroid hormone receptor associated protein 3 Q9Y2W1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10198638,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Craniata THRB HGNC:11799 thyroid hormone receptor, beta P10828 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9765220,9765220 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Metazoa THRSP HGNC:11800 thyroid hormone responsive Q92748 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9618526,9777755,9618526 secreted 19 0 cytoplasm. nucleus multiple Theria Theria Euteleostomi THSD1 HGNC:17754 thrombospondin, type I, domain containing 1 Q9NS62 Isoform 1: Membrane; Single-pass type I membrane protein (Potential). Isoform 2: Membrane; Single-pass type I membrane protein (Potential). Isoform 3: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 15371459,15371459 secreted 32 1 plasma membrane. secreted multiple Tetrapoda Euteleostomi Eumetazoa THSD4 HGNC:25835 thrombospondin, type I, domain containing 4 Q6ZMP0 Secreted, extracellular space, extracellular matrix (By similarity). secreted 34 0 secreted secreted Deuterostomia Eukaryota Eukaryota THSD7A HGNC:22207 thrombospondin, type I, domain containing 7A Q9UPZ6 Cell membrane; Single-pass type I membrane protein. Secreted. secreted 21 1 plasma membrane. secreted multiple Euteleostomi Deuterostomia Eukaryota THSD7B HGNC:29348 thrombospondin, type I, domain containing 7B Q9C0I4 Membrane; Single-pass type I membrane protein (Potential). secreted 20 1 secreted secreted Euteleostomi Deuterostomia Eukaryota THTPA HGNC:18987 thiamine triphosphatase Q9BU02 Cytoplasm. Extracellular (GO:0005576) 11827967 cytoplasm 100 0 cytoplasm. secreted multiple NA NA Holozoa THUMPD1 HGNC:23807 THUMP domain containing 1 Q9NXG2 Cytoplasm (GO:0005737) 17081983 nucleus 70 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota THUMPD2 HGNC:14890 THUMP domain containing 2 Q9BTF0 cytoplasm 51 0 cytoplasm cytoplasm Tetrapoda Cell.Organisms Cell.Organisms THUMPD3 HGNC:24493 THUMP domain containing 3 Q9BV44 cytoplasm 50 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms THY1 HGNC:11801 Thy-1 cell surface antigen P04216 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886) 2884261 plasma membrane 16 1 plasma membrane plasma membrane Tetrapoda Euteleostomi Tetrapoda THYN1 HGNC:29560 thymocyte nuclear protein 1 Q9P016 Nucleus (By similarity). Nucleus (GO:0005634) 14601557,14580360,12384300 nucleus 78 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms TIA1 HGNC:11802 TIA1 cytotoxic granule-associated RNA binding protein P31483 Cytoplasmic granule. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 2104899,11106748,11106748 mitochondrion 22 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms TIAF1 HGNC:11803 TGFB1-induced anti-apoptotic factor 1 O95411 Nucleus. Nucleus (GO:0005634) 9918798 nucleus 100 0 nucleus nucleus NA NA Homo TIAL1 HGNC:11804 TIA1 cytotoxic granule-associated RNA binding protein-like 1 Q01085 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Lysosome (GO:0005764) 7533298,7533298,1326761 mitochondrion 28 0 cytoplasm. lysosome. nucleus multiple Bilateria Eukaryota Cell.Organisms TIAM1 HGNC:11805 T-cell lymphoma invasion and metastasis 1 Q13009 Cell junction. Note=Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9128250,9128250,12446731 secreted 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota TIAM2 HGNC:11806 T-cell lymphoma invasion and metastasis 2 Q8IVF5 Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, filopodium (By similarity). Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites (By similarity). secreted 35 0 secreted secreted Bilateria Bilateria Eukaryota TICAM1 HGNC:18348 toll-like receptor adaptor molecule 1 Q8IUC6 nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Craniata TICAM2 HGNC:21354 toll-like receptor adaptor molecule 2 Q86XR7 Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1. nucleus 26 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple NA NA Eukaryota TICRR HGNC:28704 TOPBP1-interacting checkpoint and replication regulator Q7Z2Z1 Nucleus. Note=Associates with chromatin. nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa TIE1 HGNC:11809 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 P35590 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 1312667 plasma membrane 100 1 plasma membrane plasma membrane Deuterostomia Deuterostomia Cell.Organisms TIFA HGNC:19075 TRAF-interacting protein with forkhead-associated domain Q96CG3 Cytoplasm (GO:0005737) 11798190 nucleus 46 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Craniata TIFAB HGNC:34024 TRAF-interacting protein with forkhead-associated domain, family member B Q6ZNK6 nucleus 38 0 nucleus nucleus NA NA Euteleostomi TIGD1 HGNC:14523 tigger transposable element derived 1 Q96MW7 Nucleus (Probable). nucleus 10 0 nucleus nucleus NA NA Eukaryota TIGD2 HGNC:18333 tigger transposable element derived 2 Q4W5G0 Nucleus (By similarity). Nucleus (GO:0005634) 17081983 nucleus 17 0 nucleus nucleus Mammalia Opisthokonta Eukaryota TIGD3 HGNC:18334 tigger transposable element derived 3 Q6B0B8 Nucleus (By similarity). nucleus 17 0 nucleus nucleus Eutheria Eutheria Eukaryota TIGD4 HGNC:18335 tigger transposable element derived 4 Q8IY51 Nucleus (Probable). nucleus 15 0 nucleus nucleus Theria Bilateria Eukaryota TIGD5 HGNC:18336 tigger transposable element derived 5 Q53EQ6 Nucleus (Probable). nucleus 41 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota TIGD6 HGNC:18332 tigger transposable element derived 6 Q17RP2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 18 0 nucleus nucleus Catarrhini Opisthokonta Eukaryota TIGD7 HGNC:18331 tigger transposable element derived 7 Q6NT04 Nucleus (Probable). nucleus 12 0 nucleus nucleus Homininae Mammalia Eukaryota TIGIT HGNC:26838 T cell immunoreceptor with Ig and ITIM domains Q495A1 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Theria Theria Euteleostomi TIMD4 HGNC:25132 T-cell immunoglobulin and mucin domain containing 4 Q96H15 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 25 1 plasma membrane plasma membrane Amniota Euteleostomi Euteleostomi TIMELESS HGNC:11813 timeless circadian clock Q9UNS1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9856465,17081983,9856465 nucleus 100 2 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TIMM10 HGNC:11814 translocase of inner mitochondrial membrane 10 homolog (yeast) P62072 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 14726512,9430585 mitochondrion 29 0 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota TIMM10B HGNC:4022 translocase of inner mitochondrial membrane 10 homolog B (yeast) Q9Y5J6 Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 14726512,14726512 mitochondrion 21 0 mitochondrion. mitochondrion membrane multiple Euteleostomi Bilateria Eukaryota TIMM13 HGNC:11816 translocase of inner mitochondrial membrane 13 homolog (yeast) Q9Y5L4 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion (GO:0005739) 10611480 mitochondrion 20 0 mitochondrion mitochondrion Theria Eukaryota Eukaryota TIMM17A HGNC:17315 translocase of inner mitochondrial membrane 17 homolog A (yeast) Q99595 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10339406,15598749 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota TIMM17B HGNC:17310 translocase of inner mitochondrial membrane 17 homolog B (yeast) O60830 Mitochondrion inner membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 9931253,15598749 mitochondrion membrane 100 5 mitochondrion. mitochondrion membrane. plasma membrane multiple Eukaryota Eukaryota NA TIMM21 HGNC:25010 translocase of inner mitochondrial membrane 21 homolog (yeast) Q9BVV7 Mitochondrion membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 8 1 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota Eukaryota TIMM22 HGNC:17317 translocase of inner mitochondrial membrane 22 homolog (yeast) Q9Y584 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739); Mitochondrial membrane (GO:0005740) 11864609,15598749,14726512 mitochondrion membrane 26 2 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota TIMM23 HGNC:17312 translocase of inner mitochondrial membrane 23 homolog (yeast) O14925 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 14726512,10339406,17510655,15598749 mitochondrion membrane 15 3 mitochondrion. mitochondrion membrane multiple Opisthokonta Eukaryota Eukaryota TIMM23B HGNC:23581 translocase of inner mitochondrial membrane 23 homolog B (yeast) Q5SRD1 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 14 2 mitochondrion membrane mitochondrion membrane Opisthokonta Eukaryota NA TIMM44 HGNC:17316 translocase of inner mitochondrial membrane 44 homolog (yeast) O43615 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 10339406,15598749 mitochondrion 52 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms TIMM50 HGNC:23656 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) Q3ZCQ8 Mitochondrion inner membrane; Single-pass membrane protein. Isoform 2: Nucleus speckle. Note=Nuclear and enriched in speckles with snRNPs. Mitochondrion (GO:0005739) 12437925,15044455,15561729 mitochondrion membrane 23 1 mitochondrion. mitochondrion membrane. nucleus multiple Opisthokonta Eukaryota Eukaryota TIMM8A HGNC:11817 translocase of inner mitochondrial membrane 8 homolog A (yeast) O60220 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion (GO:0005739) 11101512 mitochondrion 17 0 mitochondrion mitochondrion Opisthokonta Eukaryota NA TIMM8B HGNC:11818 translocase of inner mitochondrial membrane 8 homolog B (yeast) Q9Y5J9 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side (By similarity). Mitochondrion (GO:0005739) 10552927 mitochondrion 17 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota TIMM9 HGNC:11819 translocase of inner mitochondrial membrane 9 homolog (yeast) Q9Y5J7 Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrial membrane (GO:0005740); Mitochondrion (GO:0005739) 14726512,10611480 mitochondrion 31 0 mitochondrion. mitochondrion membrane multiple Theria Eukaryota Eukaryota TIMMDC1 HGNC:1321 translocase of inner mitochondrial membrane domain containing 1 Q9NPL8 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 87 3 mitochondrion membrane mitochondrion membrane Theria Bilateria Holozoa TIMP1 HGNC:11820 TIMP metallopeptidase inhibitor 1 P01033 Secreted. Extracellular (GO:0005576); Cell surface (GO:0009986) 3010309,16917503 secreted 100 0 secreted secreted Mammalia Mammalia Eumetazoa TIMP2 HGNC:11821 TIMP metallopeptidase inhibitor 2 P16035 Secreted. Extracellular (GO:0005576) 1480041 secreted 100 0 secreted secreted Euteleostomi Bilateria Eumetazoa TIMP3 HGNC:11822 TIMP metallopeptidase inhibitor 3 P35625 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 9642234 secreted 100 0 secreted secreted Euteleostomi Bilateria Eumetazoa TIMP4 HGNC:11823 TIMP metallopeptidase inhibitor 4 Q99727 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 8939999,12087081 secreted 100 0 cytoplasm. secreted multiple Theria Chordata Eumetazoa TINAG HGNC:14599 tubulointerstitial nephritis antigen Q9UJW2 Secreted, extracellular space, extracellular matrix, basement membrane. Extracellular (GO:0005576) 10652240 secreted 38 0 secreted secreted Bilateria Eukaryota Cell.Organisms TINAGL1 HGNC:19168 tubulointerstitial nephritis antigen-like 1 Q9GZM7 Secreted. Extracellular (GO:0005576) 11170462,10799322 secreted 100 0 secreted secreted Bilateria Eukaryota Cell.Organisms TINF2 HGNC:11824 TERF1 (TRF1)-interacting nuclear factor 2 Q9BSI4 Nucleus. Chromosome, telomere. Isoform 1: Nucleus matrix. Nucleus (GO:0005634) 10581025 nucleus 100 0 nucleus nucleus Theria Euteleostomi Deuterostomia TIPARP HGNC:23696 TCDD-inducible poly(ADP-ribose) polymerase Q7Z3E1 nucleus 39 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota TIPIN HGNC:30750 TIMELESS interacting protein Q9BVW5 Cytoplasm. Nucleus. nucleus 32 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota TIPRL HGNC:30231 TOR signaling pathway regulator O75663 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota TIRAP HGNC:17192 toll-interleukin 1 receptor (TIR) domain containing adaptor protein P58753 Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane. Cytoplasm (GO:0005737) 11544529 cytoplasm 9 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa TJAP1 HGNC:17949 tight junction associated protein 1 (peripheral) Q5JTD0 Golgi apparatus (By similarity). Cell junction, tight junction (By similarity). Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes (By similarity). Plasma membrane (GO:0005886) 11602598 secreted 12 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa TJP1 HGNC:11827 tight junction protein 1 Q07157 Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cell surface (GO:0009986); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 17081983,17081983/8395056,11313345,16944923,12169098,16944923,11292600,12488461 cytoplasm 31 0 cytoplasm. nucleus. secreted multiple Bilateria Bilateria Holozoa TJP2 HGNC:11828 tight junction protein 2 Q9UDY2 Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, tight junction (By similarity). Nucleus (By similarity). Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cell junction (GO:0030054) 9458817,11598001,17081983,11855865,17081983,15975580 cytoplasm 23 0 cytoplasm. nucleus multiple Bilateria Bilateria Holozoa TJP3 HGNC:11829 tight junction protein 3 O95049 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, tight junction (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9531559,9531559 cytoplasm 16 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa TK1 HGNC:11830 thymidine kinase 1, soluble P04183 Cytoplasm. Cytoplasm (GO:0005737) 3335503 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms TK2 HGNC:11831 thymidine kinase 2, mitochondrial O00142 Mitochondrion. Mitochondrion (GO:0005739) 11687801 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms TKT HGNC:11834 transketolase P29401 Cytoplasm (GO:0005737) peroxisome 14 0 peroxisome peroxisome Cell.Organisms Cell.Organisms NA TKTL1 HGNC:11835 transketolase-like 1 P51854 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear. Cytoplasm (GO:0005737) mitochondrion 13 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms NA TKTL2 HGNC:25313 transketolase-like 2 Q9H0I9 mitochondrion 17 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms TLCD1 HGNC:25177 TLC domain containing 1 Q96CP7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 47 5 plasma membrane plasma membrane Amniota Bilateria Eukaryota TLCD2 HGNC:33522 TLC domain containing 2 A6NGC4 Membrane; Multi-pass membrane protein (Potential). plasma membrane 50 5 plasma membrane plasma membrane Deuterostomia Deuterostomia Eumetazoa TLDC1 HGNC:29325 TBC/LysM-associated domain containing 1 Q6P9B6 mitochondrion 15 0 mitochondrion mitochondrion Bilateria Eukaryota Eukaryota TLDC2 HGNC:16112 TBC/LysM-associated domain containing 2 A0PJX2 mitochondrion 41 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota TLE1 HGNC:11837 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) Q04724 Nucleus. Note=Nuclear and chromatin- associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components. Nucleus (GO:0005634) 8713081,1303260 nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms TLE2 HGNC:11838 transducin-like enhancer of split 2 Q04725 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10825294,8808280,10825294 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms TLE3 HGNC:11839 transducin-like enhancer of split 3 Q04726 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1303260,8808280,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms TLE4 HGNC:11840 transducin-like enhancer of split 4 Q04727 Nucleus. Nucleus (GO:0005634) 12153506 nucleus 100 0 nucleus nucleus Bilateria Bilateria Cell.Organisms TLE6 HGNC:30788 transducin-like enhancer of split 6 Q9H808 Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). Nucleus (GO:0005634) cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eutheria Cell.Organisms TLK1 HGNC:11841 tousled-like kinase 1 Q9UKI8 Nucleus. Nucleus (GO:0005634) 9427565,10523312,12955071,14672703,11314006 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms TLK2 HGNC:11842 tousled-like kinase 2 Q86UE8 Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2. Nucleus (GO:0005634) 10523312 nucleus 74 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TLL1 HGNC:11843 tolloid-like 1 O43897 Secreted (Probable). Extracellular (GO:0005576) secreted 85 0 secreted secreted Bilateria Bilateria Cell.Organisms TLL2 HGNC:11844 tolloid-like 2 Q9Y6L7 Secreted (Probable). Extracellular (GO:0005576) 10806368 secreted 72 0 secreted secreted Bilateria Bilateria Cell.Organisms TLN1 HGNC:11845 talin 1 Q9Y490 Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell surface (By similarity). Cell junction, focal adhesion (By similarity). Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10610730,11279249,10806106,17081983,17081983 cytoplasm 21 0 cytoplasm. nucleus. secreted multiple Bilateria Eukaryota Eukaryota TLN2 HGNC:15447 talin 2 Q9Y4G6 Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12422220,17081983 cytoplasm 18 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TLR1 HGNC:11847 toll-like receptor 1 Q15399 Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 9435236 plasma membrane 15 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms TLR10 HGNC:15634 toll-like receptor 10 Q9BXR5 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 11267672 secreted 23 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms TLR2 HGNC:11848 toll-like receptor 2 O60603 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 9435236 secreted 17 1 plasma membrane plasma membrane Chordata Chordata Holozoa TLR3 HGNC:11849 toll-like receptor 3 O15455 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783); Endosome (GO:0005768) 9435236,16858407,16858407,16858407 plasma membrane 16 1 endoplasmic reticulum. endoplasmic reticulum membrane. endosome. nucleus. plasma membrane multiple Deuterostomia Deuterostomia Cell.Organisms TLR4 HGNC:11850 toll-like receptor 4 O00206 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794) ,11836257,16858407,19898473,,16858407 cytoplasm 14 1 golgi apparatus. plasma membrane multiple Amniota Euteleostomi Cell.Organisms TLR5 HGNC:11851 toll-like receptor 5 O60602 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 9435236 plasma membrane 15 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms TLR6 HGNC:16711 toll-like receptor 6 Q9Y2C9 Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 10231569 plasma membrane 18 1 plasma membrane plasma membrane Euteleostomi Bilateria Cell.Organisms TLR7 HGNC:15631 toll-like receptor 7 Q9NYK1 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity). Plasma membrane (GO:0005886) 11909637 secreted 14 1 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms TLR8 HGNC:15632 toll-like receptor 8 Q9NR97 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 11909637 plasma membrane 16 1 plasma membrane plasma membrane Euteleostomi Eukaryota Cell.Organisms TLR9 HGNC:15633 toll-like receptor 9 Q9NR96 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity). Endoplasmic reticulum (GO:0005783) 14716310 secreted 14 1 endoplasmic reticulum endoplasmic reticulum NA NA Cell.Organisms TLX1 HGNC:5056 T-cell leukemia homeobox 1 P31314 Nucleus (Probable). Nucleus (GO:0005634) 8099440 nucleus 40 0 nucleus nucleus Chordata Chordata Metazoa TLX1NB HGNC:37183 TLX1 neighbor P0CAT3 secreted 13 0 secreted secreted NA NA NA TLX2 HGNC:5057 T-cell leukemia homeobox 2 O43763 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9738002,9738002 nucleus 35 0 cytoplasm. nucleus multiple Theria Theria Metazoa TLX3 HGNC:13532 T-cell leukemia homeobox 3 O43711 Nucleus (Probable). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Euteleostomi Bilateria Eukaryota TM2D1 HGNC:24142 TM2 domain containing 1 Q9BX74 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 11278849 mitochondrion membrane 20 2 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Cell.Organisms TM2D2 HGNC:24127 TM2 domain containing 2 Q9BX73 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11278849 endoplasmic reticulum membrane 14 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Cell.Organisms TM2D3 HGNC:24128 TM2 domain containing 3 Q9BRN9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 11278849 secreted 16 2 n/a n/a Bilateria Cell.Organisms Cell.Organisms TM4SF1 HGNC:11853 transmembrane 4 L six family member 1 P30408 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7510285 plasma membrane 25 4 plasma membrane plasma membrane Tetrapoda Tetrapoda Craniata TM4SF18 HGNC:25181 transmembrane 4 L six family member 18 Q96CE8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 22 4 plasma membrane plasma membrane Theria Amniota Craniata TM4SF19 HGNC:25167 transmembrane 4 L six family member 19 Q96DZ7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 32 4 golgi apparatus membrane golgi apparatus membrane Mammalia Euteleostomi Opisthokonta TM4SF20 HGNC:26230 transmembrane 4 L six family member 20 Q53R12 Cell membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 21 4 golgi apparatus membrane golgi apparatus membrane Mammalia Tetrapoda Craniata TM4SF4 HGNC:11856 transmembrane 4 L six family member 4 P48230 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7665614 plasma membrane 26 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata TM4SF5 HGNC:11857 transmembrane 4 L six family member 5 O14894 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9479038 plasma membrane 28 4 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata TM6SF1 HGNC:11860 transmembrane 6 superfamily member 1 Q9BZW5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 74 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Deuterostomia Holozoa TM6SF2 HGNC:11861 transmembrane 6 superfamily member 2 Q9BZW4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 74 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Holozoa TM7SF2 HGNC:11863 transmembrane 7 superfamily member 2 O76062 Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi- pass membrane protein. Endoplasmic reticulum (GO:0005783) 9878250 nucleus membrane 49 8 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Cell.Organisms TM7SF3 HGNC:23049 transmembrane 7 superfamily member 3 Q9NS93 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10828615 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Holozoa TM9SF1 HGNC:11864 transmembrane 9 superfamily member 1 O15321 Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11595169,9332367 golgi apparatus membrane 12 9 lysosome membrane. plasma membrane multiple Theria Eukaryota Eukaryota TM9SF2 HGNC:11865 transmembrane 9 superfamily member 2 Q99805 Endosome membrane; Multi-pass membrane protein (Probable). Endosome (GO:0005768); Mitochondrion (GO:0005739) 9729438,15598749 golgi apparatus membrane 12 9 endosome. endosome membrane. mitochondrion multiple Eukaryota Eukaryota Eukaryota TM9SF3 HGNC:21529 transmembrane 9 superfamily member 3 Q9HD45 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 11595169 golgi apparatus membrane 12 9 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota TM9SF4 HGNC:30797 transmembrane 9 superfamily protein member 4 Q92544 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021); Mitochondrion (GO:0005739) ,15598749 golgi apparatus membrane 16 9 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota TMA16 HGNC:25638 translation machinery associated 16 homolog (S. cerevisiae) Q96EY4 nucleus 4 0 nucleus nucleus Deuterostomia Eukaryota Opisthokonta TMA7 HGNC:26932 translation machinery associated 7 homolog (S. cerevisiae) Q9Y2S6 Nucleus (GO:0005634) 16096800 cytoplasm 37 0 nucleus nucleus NA NA NA TMBIM1 HGNC:23410 transmembrane BAX inhibitor motif containing 1 Q969X1 Membrane; Multi-pass membrane protein (By similarity). Lysosome membrane. Endosome membrane. golgi apparatus membrane 15 7 golgi apparatus membrane golgi apparatus membrane Euteleostomi Opisthokonta Eukaryota TMBIM4 HGNC:24257 transmembrane BAX inhibitor motif containing 4 Q9HC24 Golgi apparatus membrane; Multi-pass membrane protein. golgi apparatus membrane 100 7 golgi apparatus membrane golgi apparatus membrane Opisthokonta Cell.Organisms Cell.Organisms TMBIM6 HGNC:11723 transmembrane BAX inhibitor motif containing 6 P55061 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783) 9660918,10087504 endoplasmic reticulum membrane 100 7 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Cell.Organisms Eukaryota TMC1 HGNC:16513 transmembrane channel-like 1 Q8TDI8 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11850618 plasma membrane 22 10 plasma membrane plasma membrane Chordata Bilateria Holozoa TMC2 HGNC:16527 transmembrane channel-like 2 Q8TDI7 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11850618 plasma membrane 24 9 plasma membrane plasma membrane Chordata Bilateria Holozoa TMC3 HGNC:22995 transmembrane channel-like 3 Q7Z5M5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 25 10 plasma membrane plasma membrane Chordata Bilateria Holozoa TMC4 HGNC:22998 transmembrane channel-like 4 Q7Z404 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12812529 endoplasmic reticulum membrane 21 10 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Mammalia NA TMC5 HGNC:22999 transmembrane channel-like 5 Q6UXY8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12812529 endoplasmic reticulum membrane 24 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Bilateria Holozoa TMC6 HGNC:18021 transmembrane channel-like 6 Q7Z403 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12426567,17081983 endoplasmic reticulum membrane 100 11 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Euteleostomi Euteleostomi Holozoa TMC7 HGNC:23000 transmembrane channel-like 7 Q7Z402 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12812529 endoplasmic reticulum membrane 19 11 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Bilateria Holozoa TMC8 HGNC:20474 transmembrane channel-like 8 Q8IU68 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12426567,17081983,17081983 endoplasmic reticulum membrane 100 10 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Human Tetrapoda Holozoa TMCC1 HGNC:29116 transmembrane and coiled-coil domain family 1 O94876 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 23 2 cytoplasm cytoplasm Bilateria Bilateria Metazoa TMCC2 HGNC:24239 transmembrane and coiled-coil domain family 2 O75069 Membrane; Multi-pass membrane protein (Potential). cytoplasm 21 2 cytoplasm cytoplasm Bilateria Bilateria Eumetazoa TMCC3 HGNC:29199 transmembrane and coiled-coil domain family 3 Q9ULS5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 7 2 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa TMCO1 HGNC:18188 transmembrane and coiled-coil domains 1 Q9UM00 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytosol (GO:0005829) 10393320,10393320,10393320 mitochondrion membrane 24 3 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Eukaryota Eukaryota Eukaryota TMCO2 HGNC:23312 transmembrane and coiled-coil domains 2 Q7Z6W1 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 10 1 secreted secreted Theria Theria Mammalia TMCO3 HGNC:20329 transmembrane and coiled-coil domains 3 Q6UWJ1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 12 12 mitochondrion membrane mitochondrion membrane Deuterostomia Cell.Organisms Cell.Organisms TMCO4 HGNC:27393 transmembrane and coiled-coil domains 4 Q5TGY1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 21 3 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota Cell.Organisms TMCO5A HGNC:28558 transmembrane and coiled-coil domains 5A Q8N6Q1 Membrane; Single-pass membrane protein (Potential). golgi apparatus membrane 13 1 golgi apparatus membrane golgi apparatus membrane Theria Theria Mammalia TMCO6 HGNC:28814 transmembrane and coiled-coil domains 6 Q96DC7 Membrane; Multi-pass membrane protein (Potential). cytoplasm 9 2 cytoplasm cytoplasm Amniota Euteleostomi Bilateria TMED1 HGNC:17291 transmembrane emp24 protein transport domain containing 1 Q13445 Cell membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8621446 endoplasmic reticulum membrane 10 1 endoplasmic reticulum membrane. golgi apparatus membrane. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota TMED10 HGNC:16998 transmembrane emp24-like trafficking protein 10 (yeast) P49755 Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein (By similarity). Cell membrane (By similarity). Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway. Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Microsome (GO:0005792); Plasma membrane (GO:0005886); Zymogen granule (GO:0042588); Mitochondrion (GO:0005739) 8663407,8663407,8663407,8663407,8663407,16278343,15598749 endoplasmic reticulum membrane 18 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. melanosome. mitochondrion. plasma membrane multiple Eukaryota Eukaryota Eukaryota TMED2 HGNC:16996 transmembrane emp24 domain trafficking protein 2 Q15363 Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway. Golgi apparatus (GO:0005794); Microsome (GO:0005792); Plasma membrane (GO:0005886) 10214941,11739402,8663407,11739402 golgi apparatus membrane 14 1 endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane. plasma membrane multiple Eukaryota Eukaryota Eukaryota TMED3 HGNC:28889 transmembrane emp24 protein transport domain containing 3 Q9Y3Q3 Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI- coated vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Probably cycles between compartments of the early secretatory pathway. Integral to membrane (GO:0016021) golgi apparatus membrane 14 1 endoplasmic reticulum membrane. golgi apparatus membrane multiple Opisthokonta Eukaryota Eukaryota TMED4 HGNC:22301 transmembrane emp24 protein transport domain containing 4 Q7Z7H5 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). endoplasmic reticulum membrane 93 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Opisthokonta Eukaryota Eukaryota TMED5 HGNC:24251 transmembrane emp24 protein transport domain containing 5 Q9Y3A6 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early secretatory pathway. Membrane fraction (GO:0005624) 15308636 endoplasmic reticulum membrane 12 1 endoplasmic reticulum membrane. golgi apparatus membrane multiple Bilateria Opisthokonta Eukaryota TMED6 HGNC:28331 transmembrane emp24 protein transport domain containing 6 Q8WW62 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 10 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Bilateria Eukaryota TMED7 HGNC:24253 transmembrane emp24 protein transport domain containing 7 Q9Y3B3 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, COPII-coated vesicle membrane; Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory pathway. golgi apparatus membrane 12 1 endoplasmic reticulum membrane. golgi apparatus membrane multiple Human Human Eukaryota TMED8 HGNC:18633 transmembrane emp24 protein transport domain containing 8 Q6PL24 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Bilateria Holozoa TMED9 HGNC:24878 transmembrane emp24 protein transport domain containing 9 Q9BVK6 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory pathway. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10744732,1918067,15598749 endoplasmic reticulum membrane 73 1 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus membrane. mitochondrion multiple Opisthokonta Eukaryota Eukaryota TMEFF1 HGNC:11866 transmembrane protein with EGF-like and two follistatin-like domains 1 Q8IYR6 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 12743596 plasma membrane 100 2 plasma membrane plasma membrane NA NA Eukaryota TMEFF2 HGNC:11867 transmembrane protein with EGF-like and two follistatin-like domains 2 Q9UIK5 Isoform 1: Membrane; Single-pass type I membrane protein (Potential). Isoform 2: Membrane; Single-pass type I membrane protein (Potential). Isoform 3: Secreted. Plasma membrane (GO:0005886) 11668495 plasma membrane 43 2 plasma membrane. secreted multiple Chordata Chordata Eukaryota TMEM100 HGNC:25607 transmembrane protein 100 Q9NV29 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 46 2 plasma membrane plasma membrane Euteleostomi Euteleostomi Euteleostomi TMEM101 HGNC:28653 transmembrane protein 101 Q96IK0 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 46 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Deuterostomia Eumetazoa TMEM102 HGNC:26722 transmembrane protein 102 Q8N9M5 Cell membrane; Single-pass membrane protein. Note=Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments. plasma membrane 100 0 plasma membrane plasma membrane Theria Theria Eumetazoa TMEM104 HGNC:25984 transmembrane protein 104 Q8NE00 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983,17081983 endoplasmic reticulum membrane 22 11 nucleus nucleus Bilateria Eukaryota Eukaryota TMEM105 HGNC:26794 transmembrane protein 105 Q8N8V8 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) secreted 22 2 n/a n/a Catarrhini Catarrhini Eutheria TMEM106A HGNC:28288 transmembrane protein 106A Q96A25 Membrane; Single-pass membrane protein (Potential). endoplasmic reticulum membrane 23 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Metazoa TMEM106B HGNC:22407 transmembrane protein 106B Q9NUM4 Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 35 1 endosome membrane. lysosome membrane multiple Euteleostomi Euteleostomi Metazoa TMEM106C HGNC:28775 transmembrane protein 106C Q9BVX2 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Euteleostomi Metazoa TMEM107 HGNC:28128 transmembrane protein 107 Q6UX40 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 40 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eukaryota Metazoa TMEM108 HGNC:28451 transmembrane protein 108 Q6UXF1 Membrane; Single-pass type I membrane protein (Potential). nucleus 15 1 nucleus nucleus Amniota Amniota Craniata TMEM109 HGNC:28771 transmembrane protein 109 Q9BVC6 Nucleus outer membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi- pass membrane protein (By similarity). Sarcoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). plasma membrane 49 4 plasma membrane plasma membrane Mammalia Mammalia Amniota TMEM11 HGNC:16823 transmembrane protein 11 P17152 Mitochondrion inner membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 2110658 mitochondrion membrane 100 3 mitochondrion membrane. plasma membrane multiple Deuterostomia Bilateria Holozoa TMEM110 HGNC:30526 transmembrane protein 110 Q86TL2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) vacuole membrane 15 5 vacuole membrane vacuole membrane Deuterostomia Eukaryota Eukaryota TMEM114 HGNC:33227 transmembrane protein 114 B3SHH9 Cell membrane (By similarity); Multi-pass membrane protein (Potential). plasma membrane 81 3 plasma membrane plasma membrane NA NA Euteleostomi TMEM115 HGNC:30055 transmembrane protein 115 Q12893 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 11085536 golgi apparatus membrane 8 6 plasma membrane plasma membrane Theria Eukaryota Eukaryota TMEM116 HGNC:25084 transmembrane protein 116 Q8NCL8 Membrane; Multi-pass membrane protein (Potential). plasma membrane 50 4 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa TMEM117 HGNC:25308 transmembrane protein 117 Q9H0C3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 45 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Euteleostomi Eumetazoa TMEM119 HGNC:27884 transmembrane protein 119 Q4V9L6 Membrane; Single-pass type I membrane protein (Potential). secreted 70 1 secreted secreted Euteleostomi Euteleostomi Euteleostomi TMEM120A HGNC:21697 transmembrane protein 120A Q9BXJ8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 38 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota NA TMEM120B HGNC:32008 transmembrane protein 120B A0PK00 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 46 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota TMEM121 HGNC:20511 transmembrane protein 121 Q9BTD3 Membrane; Multi-pass membrane protein (Potential). plasma membrane 48 8 plasma membrane plasma membrane Theria Euteleostomi NA TMEM123 HGNC:30138 transmembrane protein 123 Q8N131 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 11481458,9600958 endoplasmic reticulum membrane 87 1 plasma membrane plasma membrane Theria Amniota Bilateria TMEM125 HGNC:28275 transmembrane protein 125 Q96AQ2 Membrane; Multi-pass membrane protein (Potential). plasma membrane 40 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Euteleostomi TMEM126A HGNC:25382 transmembrane protein 126A Q9H061 Mitochondrion inner membrane; Multi-pass membrane protein. mitochondrion membrane 100 4 mitochondrion membrane mitochondrion membrane Deuterostomia Deuterostomia Deuterostomia TMEM126B HGNC:30883 transmembrane protein 126B Q8IUX1 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) mitochondrion membrane 48 4 mitochondrion membrane mitochondrion membrane Deuterostomia Deuterostomia Chordata TMEM127 HGNC:26038 transmembrane protein 127 O75204 Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. plasma membrane 63 4 cytoplasm. plasma membrane multiple Theria Deuterostomia Eumetazoa TMEM128 HGNC:28201 transmembrane protein 128 Q5BJH2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 47 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Holozoa TMEM129 HGNC:25137 transmembrane protein 129 A0AVI4 Membrane; Multi-pass membrane protein (Potential). secreted 26 3 n/a n/a Bilateria Bilateria Holozoa TMEM130 HGNC:25429 transmembrane protein 130 Q8N3G9 Golgi apparatus membrane; Single-pass type I membrane protein. golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Tetrapoda NA TMEM131 HGNC:30366 transmembrane protein 131 Q92545 Membrane; Multi-pass membrane protein (Potential). nucleus 12 4 nucleus nucleus Bilateria Bilateria Eukaryota TMEM132A HGNC:31092 transmembrane protein 132A Q24JP5 Golgi apparatus membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12514190,12514190 plasma membrane 43 1 endoplasmic reticulum. golgi apparatus multiple Eutheria Mammalia Holozoa TMEM132B HGNC:29397 transmembrane protein 132B Q14DG7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 43 1 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa TMEM132C HGNC:25436 transmembrane protein 132C Q8N3T6 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 36 1 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa TMEM132D HGNC:29411 transmembrane protein 132D Q14C87 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 42 1 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa TMEM132E HGNC:26991 transmembrane protein 132E Q6IEE7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 46 1 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa TMEM133 HGNC:24033 transmembrane protein 133 Q9H2Q1 Membrane; Multi-pass membrane protein (Potential). secreted 41 2 n/a n/a Homininae Homininae Homo TMEM134 HGNC:26142 transmembrane protein 134 Q9H6X4 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 31 2 golgi apparatus membrane golgi apparatus membrane Theria Bilateria Bilateria TMEM135 HGNC:26167 transmembrane protein 135 Q86UB9 Membrane; Multi-pass membrane protein (Potential). Peroxisome (By similarity). mitochondrion membrane 25 9 mitochondrion membrane mitochondrion membrane Chordata Eukaryota Eukaryota TMEM136 HGNC:28280 transmembrane protein 136 Q6ZRR5 Membrane; Multi-pass membrane protein (Potential). plasma membrane 39 7 plasma membrane plasma membrane Chordata Eukaryota Eukaryota TMEM138 HGNC:26944 transmembrane protein 138 Q9NPI0 Vacuole membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes to vesicles en route to the base of cilium. endoplasmic reticulum membrane 64 3 vacuole membrane vacuole membrane Bilateria Bilateria Metazoa TMEM139 HGNC:22058 transmembrane protein 139 Q8IV31 Membrane; Single-pass type I membrane protein (Potential). secreted 45 1 secreted secreted Amniota Amniota Amniota TMEM140 HGNC:21870 transmembrane protein 140 Q9NV12 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 24 4 plasma membrane plasma membrane Theria Amniota Amniota TMEM141 HGNC:28211 transmembrane protein 141 Q96I45 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 24 2 mitochondrion membrane mitochondrion membrane NA NA Craniata TMEM143 HGNC:25603 transmembrane protein 143 Q96AN5 Membrane; Multi-pass membrane protein (Potential). cytoplasm 20 2 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TMEM144 HGNC:25633 transmembrane protein 144 Q7Z5S9 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) golgi apparatus membrane 58 10 golgi apparatus membrane golgi apparatus membrane Tetrapoda Eukaryota Eukaryota TMEM145 HGNC:26912 transmembrane protein 145 Q8NBT3 Membrane; Multi-pass membrane protein (Potential). plasma membrane 49 7 plasma membrane plasma membrane Bilateria Bilateria Eukaryota TMEM147 HGNC:30414 transmembrane protein 147 Q9BVK8 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Eukaryota Eukaryota TMEM14A HGNC:21076 transmembrane protein 14A Q9Y6G1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 42 4 mitochondrion membrane mitochondrion membrane Euteleostomi Euteleostomi Eukaryota TMEM14B HGNC:21384 transmembrane protein 14B Q9NUH8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 63 4 mitochondrion membrane mitochondrion membrane Catarrhini Catarrhini Opisthokonta TMEM14C HGNC:20952 transmembrane protein 14C Q9P0S9 Mitochondrion membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) mitochondrion membrane 76 4 mitochondrion membrane mitochondrion membrane Human Eukaryota Eukaryota TMEM14E HGNC:34386 transmembrane protein 14E Q6UXP3 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 53 3 mitochondrion membrane mitochondrion membrane NA NA Eumetazoa TMEM150A HGNC:24677 transmembrane protein 150A Q86TG1 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886) 10858565 plasma membrane 90 6 plasma membrane plasma membrane Chordata Chordata Holozoa TMEM150B HGNC:34415 transmembrane protein 150B A6NC51 Membrane; Multi-pass membrane protein (Potential). plasma membrane 23 6 plasma membrane plasma membrane Chordata Chordata Holozoa TMEM150C HGNC:37263 transmembrane protein 150C B9EJG8 Membrane; Multi-pass membrane protein (Potential). plasma membrane 12 6 plasma membrane plasma membrane NA NA Metazoa TMEM151A HGNC:28497 transmembrane protein 151A Q8N4L1 Membrane; Multi-pass membrane protein (Potential). secreted 20 3 n/a n/a Euteleostomi Bilateria Holozoa TMEM151B HGNC:21315 transmembrane protein 151B Q8IW70 Membrane; Multi-pass membrane protein (Potential). plasma membrane 33 3 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa TMEM154 HGNC:26489 transmembrane protein 154 Q6P9G4 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 68 1 plasma membrane plasma membrane Euarchontoglires Amniota Euteleostomi TMEM155 HGNC:26418 transmembrane protein 155 Q4W5P6 Secreted (Potential). secreted 30 2 n/a n/a Catarrhini Catarrhini Eutheria TMEM156 HGNC:26260 transmembrane protein 156 Q8N614 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 10 2 plasma membrane plasma membrane Amniota Amniota Amniota TMEM158 HGNC:30293 transmembrane protein 158 (gene/pseudogene) Q8WZ71 Membrane; Multi-pass membrane protein (Potential). secreted 45 1 secreted secreted NA NA Craniata TMEM159 HGNC:30136 transmembrane protein 159 Q96B96 Membrane; Multi-pass membrane protein (Potential). Cytoplasm (GO:0005737) 15589683 golgi apparatus membrane 41 3 cytoplasm cytoplasm Tetrapoda Tetrapoda Craniata TMEM160 HGNC:26042 transmembrane protein 160 Q9NX00 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) plasma membrane 14 3 plasma membrane plasma membrane Theria Euteleostomi Deuterostomia TMEM161A HGNC:26020 transmembrane protein 161A Q9NX61 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 40 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Euteleostomi Eumetazoa TMEM161B HGNC:28483 transmembrane protein 161B Q8NDZ6 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 48 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Metazoa TMEM163 HGNC:25380 transmembrane protein 163 Q8TC26 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Early endosome membrane (By similarity). Note=Glutamatergic synaptic vesicles (By similarity). plasma membrane 48 6 plasma membrane plasma membrane Chordata Chordata Eumetazoa TMEM164 HGNC:26217 transmembrane protein 164 Q5U3C3 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 59 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota TMEM165 HGNC:30760 transmembrane protein 165 Q9HC07 Golgi apparatus membrane; Multi-pass membrane protein (Probable). Golgi apparatus, trans-Golgi network membrane. Lysosome membrane. Early endosome membrane. Late endosome membrane. mitochondrion membrane 26 6 golgi apparatus membrane golgi apparatus membrane Eukaryota Cell.Organisms Cell.Organisms TMEM167A HGNC:28330 transmembrane protein 167A Q8TBQ9 Golgi apparatus membrane; Single-pass type I membrane protein. golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane Tetrapoda Eukaryota Eukaryota TMEM167B HGNC:30187 transmembrane protein 167B Q9NRX6 Golgi apparatus membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) golgi apparatus membrane 100 1 golgi apparatus membrane golgi apparatus membrane NA NA Eukaryota TMEM168 HGNC:25826 transmembrane protein 168 Q9H0V1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 26 12 plasma membrane plasma membrane Euteleostomi Deuterostomia Eumetazoa TMEM169 HGNC:25130 transmembrane protein 169 Q96HH4 Membrane; Multi-pass membrane protein (Potential). plasma membrane 20 2 plasma membrane plasma membrane Euteleostomi Bilateria Bilateria TMEM17 HGNC:26623 transmembrane protein 17 Q86X19 Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the transition zone of primary cilia (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 36 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Metazoa TMEM170A HGNC:29577 transmembrane protein 170A Q8WVE7 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 16 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Holozoa TMEM170B HGNC:34244 transmembrane protein 170B Q5T4T1 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 13 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Human Holozoa TMEM171 HGNC:27031 transmembrane protein 171 Q8WVE6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 35 4 plasma membrane plasma membrane Tetrapoda Tetrapoda Tetrapoda TMEM173 HGNC:27962 transmembrane protein 173 Q86WV6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited. secreted 20 4 cytoplasm. endoplasmic reticulum membrane. mitochondrion membrane multiple Tetrapoda Bilateria Eumetazoa TMEM174 HGNC:28187 transmembrane protein 174 Q8WUU8 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Craniata TMEM175 HGNC:28709 transmembrane protein 175 Q9BSA9 Membrane; Multi-pass membrane protein (Potential). plasma membrane 47 12 plasma membrane plasma membrane Amniota Cell.Organisms Cell.Organisms TMEM176A HGNC:24930 transmembrane protein 176A Q96HP8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus membrane 18 4 nucleus membrane nucleus membrane Homininae Eutheria Craniata TMEM176B HGNC:29596 transmembrane protein 176B Q3YBM2 Nucleus membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) nucleus membrane 43 4 nucleus membrane nucleus membrane Mammalia Mammalia Mammalia TMEM177 HGNC:28143 transmembrane protein 177 Q53S58 Membrane; Multi-pass membrane protein (Potential). mitochondrion 41 3 mitochondrion mitochondrion Eutheria Bilateria Eumetazoa TMEM178A HGNC:28517 transmembrane protein 178A Q8NBL3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 28 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Olfactores TMEM178B HGNC:44112 transmembrane protein 178B H3BS89 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 45 3 golgi apparatus membrane golgi apparatus membrane NA NA Olfactores TMEM179 HGNC:20137 transmembrane protein 179 Q6ZVK1 Membrane; Multi-pass membrane protein (Potential). plasma membrane 45 4 plasma membrane plasma membrane NA NA Bilateria TMEM179B HGNC:33744 transmembrane protein 179B Q7Z7N9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 52 3 plasma membrane plasma membrane Mammalia Euteleostomi Craniata TMEM18 HGNC:25257 transmembrane protein 18 Q96B42 Cytoplasm. Nucleus membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) nucleus membrane 97 3 cytoplasm. nucleus membrane multiple Euteleostomi Eukaryota Eukaryota TMEM180 HGNC:26196 transmembrane protein 180 Q14CX5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 12 13 mitochondrion membrane mitochondrion membrane Chordata Bilateria Holozoa TMEM181 HGNC:20958 transmembrane protein 181 Q9P2C4 Membrane; Multi-pass membrane protein (Potential). secreted 15 8 n/a n/a Deuterostomia Eukaryota Eukaryota TMEM182 HGNC:26391 transmembrane protein 182 Q6ZP80 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 12975309 golgi apparatus membrane 35 3 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Craniata TMEM183A HGNC:20173 transmembrane protein 183A Q8IXX5 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 60 1 nucleus nucleus Euteleostomi Bilateria Eumetazoa TMEM183B HGNC:33205 transmembrane protein 183B Q1AE95 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886) 16644869 nucleus 59 1 plasma membrane plasma membrane NA NA NA TMEM184A HGNC:28797 transmembrane protein 184A Q6ZMB5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 26 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Human Eukaryota TMEM184B HGNC:1310 transmembrane protein 184B Q9Y519 Membrane; Multi-pass membrane protein (Potential). Cytoplasm (GO:0005737) 17081983 endoplasmic reticulum membrane 24 7 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota TMEM184C HGNC:25587 transmembrane protein 184C Q9NVA4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 46 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota TMEM185A HGNC:17125 transmembrane protein 185A Q8NFB2 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 39 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Holozoa TMEM185B HGNC:18896 transmembrane protein 185B Q9H7F4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 42 8 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Holozoa TMEM186 HGNC:24530 transmembrane protein 186 Q96B77 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 30 2 mitochondrion membrane mitochondrion membrane Theria Bilateria Eukaryota TMEM187 HGNC:13705 transmembrane protein 187 Q14656 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 52 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Deuterostomia NA TMEM189 HGNC:16735 transmembrane protein 189 A5PLL7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11076848,11076860 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane multiple NA NA Cell.Organisms TMEM19 HGNC:25605 transmembrane protein 19 Q96HH6 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 11 8 golgi apparatus membrane golgi apparatus membrane Euteleostomi Cell.Organisms Cell.Organisms TMEM190 HGNC:29632 transmembrane protein 190 Q8WZ59 Membrane; Single-pass type I membrane protein (By similarity). secreted 79 1 secreted secreted Theria Theria Mammalia TMEM191B HGNC:33600 transmembrane protein 191B P0C7N4 Membrane; Multi-pass membrane protein (Potential). secreted 6 3 n/a n/a NA NA NA TMEM192 HGNC:26775 transmembrane protein 192 Q8IY95 Lysosome membrane; Multi-pass membrane protein. Late endosome. Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,17081983 plasma membrane 53 4 endosome. lysosome membrane multiple Euteleostomi Bilateria Metazoa TMEM194A HGNC:29001 transmembrane protein 194A O14524 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 51 7 golgi apparatus membrane golgi apparatus membrane Bilateria Eukaryota Metazoa TMEM194B HGNC:33700 transmembrane protein 194B A6NFY4 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 37 7 golgi apparatus membrane golgi apparatus membrane Human Human Metazoa TMEM196 HGNC:22431 transmembrane protein 196 Q5HYL7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 47 4 plasma membrane plasma membrane Amniota Euteleostomi Craniata TMEM198 HGNC:33704 transmembrane protein 198 Q66K66 Membrane; Multi-pass membrane protein (Potential). Cell membrane (By similarity). Cytoplasmic vesicle (By similarity). Note=Largely located to vesicle-like structures (By similarity). Integral to membrane (GO:0016021) plasma membrane 8 7 plasma membrane plasma membrane Deuterostomia Bilateria Bilateria TMEM199 HGNC:18085 transmembrane protein 199 Q8N511 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 46 2 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA NA TMEM2 HGNC:11869 transmembrane protein 2 Q9UHN6 Membrane; Single-pass membrane protein (Potential). cytoplasm 55 1 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms TMEM200A HGNC:21075 transmembrane protein 200A Q86VY9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 44 2 plasma membrane plasma membrane Amniota Euteleostomi Craniata TMEM200B HGNC:33785 transmembrane protein 200B Q69YZ2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 39 2 plasma membrane plasma membrane NA NA Euteleostomi TMEM200C HGNC:37208 transmembrane protein 200C A6NKL6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 15722956 plasma membrane 51 2 plasma membrane plasma membrane Euarchontoglires Euteleostomi Craniata TMEM201 HGNC:33719 transmembrane protein 201 Q5SNT2 Isoform SAMP1: Nucleus inner membrane; Multi-pass membrane protein. Note=The C-terminal of isoform SAMP1 is located on the nucleoplasmic side. During interphase, isoform SAMP1 is distributed in the inner nuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. Integral to membrane (GO:0016021) nucleus membrane 100 6 nucleus membrane nucleus membrane Amniota Eukaryota Eukaryota TMEM202 HGNC:33733 transmembrane protein 202 A6NGA9 Membrane; Multi-pass membrane protein (Potential). plasma membrane 26 4 plasma membrane plasma membrane Theria Theria Euteleostomi TMEM203 HGNC:28217 transmembrane protein 203 Q969S6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 54 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eumetazoa TMEM204 HGNC:14158 transmembrane protein 204 Q9BSN7 Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Note=Co-localizes with the beta-catenin adherins. Cell junction (GO:0030054) 15206924 secreted 48 3 plasma membrane plasma membrane Euteleostomi Euteleostomi Craniata TMEM205 HGNC:29631 transmembrane protein 205 Q6UW68 Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance. Integral to membrane (GO:0016021) mitochondrion membrane 16 4 mitochondrion membrane mitochondrion membrane Chordata Eukaryota Eukaryota TMEM206 HGNC:25593 transmembrane protein 206 Q9H813 Membrane; Multi-pass membrane protein (Potential). nucleus 27 2 nucleus nucleus Euteleostomi Euteleostomi Metazoa TMEM207 HGNC:33705 transmembrane protein 207 Q6UWW9 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 55 1 secreted secreted Homininae Amniota Amniota TMEM208 HGNC:25015 transmembrane protein 208 Q9BTX3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota TMEM209 HGNC:21898 transmembrane protein 209 Q96SK2 Membrane; Multi-pass membrane protein (Potential). plasma membrane 37 3 plasma membrane plasma membrane Deuterostomia Bilateria Eukaryota TMEM210 HGNC:34059 transmembrane protein 210 A6NLX4 Membrane; Single-pass type I membrane protein (Potential). secreted 61 1 secreted secreted Euarchontoglires Euarchontoglires Eutheria TMEM211 HGNC:33725 transmembrane protein 211 Q6ICI0 Membrane; Multi-pass membrane protein (Potential). plasma membrane 16 3 plasma membrane plasma membrane Theria Euteleostomi Metazoa TMEM212 HGNC:34295 transmembrane protein 212 A6NML5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 26 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Tetrapoda Tetrapoda TMEM213 HGNC:27220 transmembrane protein 213 A2RRL7 Membrane; Single-pass type I membrane protein (Potential). secreted 77 1 secreted secreted Eutheria Amniota Craniata TMEM214 HGNC:25983 transmembrane protein 214 Q6NUQ4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 100 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Bilateria Eukaryota TMEM215 HGNC:33816 transmembrane protein 215 Q68D42 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 23 2 n/a n/a Tetrapoda Tetrapoda Craniata TMEM216 HGNC:25018 transmembrane protein 216 Q9P0N5 Membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 57 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota TMEM217 HGNC:21238 transmembrane protein 217 Q8N7C4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 51 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eutheria Boreoeutheria TMEM218 HGNC:27344 transmembrane protein 218 A2RU14 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 38 3 golgi apparatus membrane golgi apparatus membrane Theria Chordata Bilateria TMEM219 HGNC:25201 transmembrane protein 219 Q86XT9 Cell membrane; Single-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 2 plasma membrane plasma membrane Mammalia Mammalia Euteleostomi TMEM220 HGNC:33757 transmembrane protein 220 Q6QAJ8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 26 5 plasma membrane plasma membrane Amniota Deuterostomia Eumetazoa TMEM221 HGNC:21943 transmembrane protein 221 A6NGB7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 70 3 plasma membrane plasma membrane Eutheria Euteleostomi Euteleostomi TMEM222 HGNC:25363 transmembrane protein 222 Q9H0R3 Membrane; Multi-pass membrane protein (Potential). plasma membrane 46 2 plasma membrane plasma membrane Eukaryota Eukaryota Eukaryota TMEM223 HGNC:28464 transmembrane protein 223 A0PJW6 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 18 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Bilateria Eumetazoa TMEM225 HGNC:32390 transmembrane protein 225 Q6GV28 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 43 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euarchontoglires Eutheria Eutheria TMEM229A HGNC:37279 transmembrane protein 229A B2RXF0 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 10 7 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Cell.Organisms TMEM229B HGNC:20130 transmembrane protein 229B Q8NBD8 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 23 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Cell.Organisms TMEM230 HGNC:15876 transmembrane protein 230 Q96A57 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 27 2 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Eukaryota TMEM231 HGNC:37234 transmembrane protein 231 Q9H6L2 Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone (By similarity). endoplasmic reticulum membrane 39 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota TMEM232 HGNC:37270 transmembrane protein 232 C9JQI7 Membrane; Multi-pass membrane protein (Potential). nucleus 67 2 nucleus nucleus Deuterostomia Deuterostomia Eumetazoa TMEM233 HGNC:37219 transmembrane protein 233 B4DJY2 Membrane; Multi-pass membrane protein (Potential). plasma membrane 91 2 plasma membrane plasma membrane NA NA Cell.Organisms TMEM234 HGNC:28837 transmembrane protein 234 Q8WY98 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 53 2 golgi apparatus membrane golgi apparatus membrane Amniota Eukaryota Eukaryota TMEM235 HGNC:27563 transmembrane protein 235 A6NFC5 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (Probable). plasma membrane 32 3 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Euteleostomi TMEM236 HGNC:23473 transmembrane protein 236 Q5W0B7 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 37 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Chordata NA TMEM237 HGNC:14432 transmembrane protein 237 Q96Q45 Membrane; Multi-pass membrane protein (Potential). Cell projection, cilium. Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L. Nucleus (GO:0005634) 17081983 endoplasmic reticulum membrane 34 4 nucleus nucleus Euteleostomi Deuterostomia Eumetazoa TMEM238 HGNC:40042 transmembrane protein 238 C9JI98 Membrane; Multi-pass membrane protein (Potential). plasma membrane 36 2 plasma membrane plasma membrane NA NA Craniata TMEM239 HGNC:40044 transmembrane protein 239 Q8WW34 Membrane; Multi-pass membrane protein (Potential). secreted 53 3 n/a n/a Human Eutheria Mammalia TMEM240 HGNC:25186 transmembrane protein 240 Q5SV17 Membrane; Multi-pass membrane protein (Potential). secreted 55 2 n/a n/a Human Amniota Craniata TMEM241 HGNC:31723 transmembrane protein 241 Q24JQ0 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 7 9 golgi apparatus membrane golgi apparatus membrane Tetrapoda Opisthokonta Eukaryota TMEM242 HGNC:17206 transmembrane protein 242 Q9NWH2 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 25 2 mitochondrion membrane mitochondrion membrane Tetrapoda Bilateria NA TMEM243 HGNC:21707 transmembrane protein 243, mitochondrial Q9BU79 Membrane; Multi-pass membrane protein (Potential). Mitochondrion (GO:0005739); Nucleus (GO:0005634) 15556294,15556294 plasma membrane 40 3 mitochondrion. nucleus multiple Euteleostomi Deuterostomia Holozoa TMEM244 HGNC:21571 transmembrane protein 244 Q5VVB8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 55 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Euteleostomi Eumetazoa TMEM245 HGNC:1363 transmembrane protein 245 Q9H330 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 57 16 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Eukaryota TMEM246 HGNC:28180 transmembrane protein 246 Q9BRR3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 33 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Bilateria Opisthokonta TMEM247 HGNC:42967 transmembrane protein 247 A6NEH6 Membrane; Multi-pass membrane protein (Potential). secreted 19 2 n/a n/a NA NA Eutheria TMEM248 HGNC:25476 transmembrane protein 248 Q9NWD8 Membrane; Multi-pass membrane protein (Potential). plasma membrane 22 2 plasma membrane plasma membrane Deuterostomia Deuterostomia Eumetazoa TMEM249 HGNC:44155 transmembrane protein 249 Q2WGJ8 Membrane; Multi-pass membrane protein (Potential). mitochondrion 13 2 mitochondrion mitochondrion NA NA Eumetazoa TMEM25 HGNC:25890 transmembrane protein 25 Q86YD3 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential). Isoform 3: Secreted (Potential). Plasma membrane (GO:0005886) plasma membrane 50 1 plasma membrane plasma membrane Mammalia Euteleostomi NA TMEM251 HGNC:20218 transmembrane protein 251 Q8N6I4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 34 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Deuterostomia Holozoa TMEM252 HGNC:28537 transmembrane protein 252 Q8N6L7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 23 2 plasma membrane plasma membrane Theria Tetrapoda Euteleostomi TMEM253 HGNC:32545 transmembrane protein 253 P0C7T8 Membrane; Multi-pass membrane protein (Potential). plasma membrane 55 4 plasma membrane plasma membrane NA NA Boreoeutheria TMEM254 HGNC:25804 transmembrane protein 254 Q8TBM7 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 42 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Deuterostomia Holozoa TMEM255A HGNC:26086 transmembrane protein 255A Q5JRV8 Membrane; Multi-pass membrane protein (Potential). plasma membrane 83 4 plasma membrane plasma membrane Tetrapoda Euteleostomi NA TMEM255B HGNC:28297 transmembrane protein 255B Q8WV15 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 83 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Bilateria TMEM256 HGNC:28618 transmembrane protein 256 Q8N2U0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 18 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Cell.Organisms Bilateria TMEM257 HGNC:2562 transmembrane protein 257 O96002 Membrane; Multi-pass membrane protein (Potential). mitochondrion 4 3 mitochondrion mitochondrion NA NA NA TMEM258 HGNC:1164 transmembrane protein 258 P61165 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 43 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Eukaryota TMEM259 HGNC:17039 transmembrane protein 259 Q4ZIN3 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Note=Cytoplasmic according to PubMed:16084606. Integral to membrane (GO:0016021) plasma membrane 38 7 cytoplasm cytoplasm Bilateria Bilateria Eukaryota TMEM26 HGNC:28550 transmembrane protein 26 Q6ZUK4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 43 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eumetazoa TMEM260 HGNC:20185 transmembrane protein 260 Q9NX78 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 46 9 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Cell.Organisms Cell.Organisms TMEM261 HGNC:30536 transmembrane protein 261 Q96GE9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 7 2 cytoplasm cytoplasm Theria Theria Euteleostomi TMEM262 HGNC:49389 transmembrane protein 262 E9PQX1 mitochondrion membrane 21 3 mitochondrion membrane mitochondrion membrane NA NA Eutheria TMEM263 HGNC:28281 transmembrane protein 263 Q8WUH6 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 30 2 cytoplasm cytoplasm Amniota Euteleostomi Olfactores TMEM27 HGNC:29437 transmembrane protein 27 Q9HBJ8 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886); Brush border (GO:0005903) 11278314,17167413 plasma membrane 39 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Olfactores TMEM30A HGNC:16667 transmembrane protein 30A Q9NV96 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 31 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota TMEM30B HGNC:27254 transmembrane protein 30B Q3MIR4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 29 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota TMEM31 HGNC:28601 transmembrane protein 31 Q5JXX7 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 17 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Catarrhini Eutheria TMEM33 HGNC:25541 transmembrane protein 33 P57088 Membrane; Multi-pass membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane fraction (GO:0005624); Integral to membrane (GO:0016021) 17215244,15561729 endoplasmic reticulum membrane 60 4 melanosome melanosome Bilateria Bilateria Eukaryota TMEM35 HGNC:25864 transmembrane protein 35 Q53FP2 Peroxisome membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle (By similarity). Note=Shedding may lead to a soluble peptide (By similarity). golgi apparatus membrane 25 4 golgi apparatus membrane golgi apparatus membrane Amniota Bilateria Bilateria TMEM37 HGNC:18216 transmembrane protein 37 Q8WXS4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 14 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Craniata TMEM38A HGNC:28462 transmembrane protein 38A Q9H6F2 Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 26 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Holozoa TMEM38B HGNC:25535 transmembrane protein 38B Q9NVV0 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 63 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Holozoa TMEM39A HGNC:25600 transmembrane protein 39A Q9NV64 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 70 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Metazoa TMEM39B HGNC:25510 transmembrane protein 39B Q9GZU3 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 59 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Human Human Holozoa TMEM40 HGNC:25620 transmembrane protein 40 Q8WWA1 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) nucleus 71 2 nucleus nucleus Theria Theria Mammalia TMEM41A HGNC:30544 transmembrane protein 41A Q96HV5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 22 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Bilateria Cell.Organisms TMEM41B HGNC:28948 transmembrane protein 41B Q5BJD5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 19 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms TMEM42 HGNC:28444 transmembrane protein 42 Q69YG0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 18 4 mitochondrion membrane mitochondrion membrane Eutheria Eukaryota Eukaryota TMEM43 HGNC:28472 transmembrane protein 43 Q9BTV4 Endoplasmic reticulum (By similarity). Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 75 4 nucleus membrane nucleus membrane Deuterostomia Eukaryota Cell.Organisms TMEM44 HGNC:25120 transmembrane protein 44 Q2T9K0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 73 7 plasma membrane plasma membrane Euarchontoglires Euteleostomi Opisthokonta TMEM45A HGNC:25480 transmembrane protein 45A Q9NWC5 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 62 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota TMEM45B HGNC:25194 transmembrane protein 45B Q96B21 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 54 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota TMEM47 HGNC:18515 transmembrane protein 47 Q9BQJ4 Membrane; Multi-pass membrane protein (Potential). Cell junction (By similarity). Plasma membrane (GO:0005886) 11472633 golgi apparatus membrane 74 4 plasma membrane plasma membrane Bilateria Bilateria Bilateria TMEM5 HGNC:13530 transmembrane protein 5 Q9Y2B1 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) 10072769 endoplasmic reticulum membrane 15 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Deuterostomia Holozoa TMEM50A HGNC:30590 transmembrane protein 50A O95807 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 10 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota TMEM50B HGNC:1280 transmembrane protein 50B P56557 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 12 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Eukaryota NA TMEM51 HGNC:25488 transmembrane protein 51 Q9NW97 Membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634) 17081983 plasma membrane 50 2 nucleus nucleus Euteleostomi Euteleostomi Euteleostomi TMEM52 HGNC:27916 transmembrane protein 52 Q8NDY8 Membrane; Single-pass membrane protein (Potential). secreted 61 1 secreted secreted Catarrhini Tetrapoda Tetrapoda TMEM52B HGNC:26438 transmembrane protein 52B Q4KMG9 Membrane; Single-pass type I membrane protein (Potential). secreted 53 1 secreted secreted Tetrapoda Tetrapoda Tetrapoda TMEM53 HGNC:26186 transmembrane protein 53 Q6P2H8 Membrane; Single-pass membrane protein (Potential). secreted 10 3 n/a n/a Bilateria Eukaryota Eukaryota TMEM54 HGNC:24143 transmembrane protein 54 Q969K7 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 69 4 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi TMEM55A HGNC:25452 transmembrane protein 55A Q8N4L2 Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome (GO:0005768); Lysosome (GO:0005764) 16365287,16365287 plasma membrane 50 2 endosome. endosome membrane. lysosome. lysosome membrane multiple Euteleostomi Euteleostomi Metazoa TMEM55B HGNC:19299 transmembrane protein 55B Q86T03 Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Apical membrane (GO:0016327) ,17254974 plasma membrane 49 2 endosome membrane. lysosome membrane multiple Bilateria Bilateria Metazoa TMEM56 HGNC:26477 transmembrane protein 56 Q96MV1 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 14 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota TMEM57 HGNC:25572 transmembrane protein 57 Q8N5G2 Nucleus membrane; Multi-pass membrane protein (By similarity). Cell projection, axon (By similarity). Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells (By similarity). Nuclear membrane (GO:0005635) 15255972 cytoplasm 18 4 nucleus membrane nucleus membrane Bilateria Bilateria Metazoa TMEM59 HGNC:1239 transmembrane protein 59 Q9BXS4 Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. Integral to membrane (GO:0016021) golgi apparatus membrane 85 1 endosome membrane. golgi apparatus membrane. lysosome membrane. plasma membrane multiple Euteleostomi Deuterostomia Eumetazoa TMEM59L HGNC:13237 transmembrane protein 59-like Q9UK28 Golgi apparatus membrane; Single-pass type I membrane protein (Probable). Integral to membrane (GO:0016021) golgi apparatus membrane 47 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Eumetazoa TMEM60 HGNC:21754 transmembrane protein 60 Q9H2L4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 47 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Bilateria TMEM61 HGNC:27296 transmembrane protein 61 Q8N0U2 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) secreted 77 2 n/a n/a Euarchontoglires Amniota Amniota TMEM62 HGNC:26269 transmembrane protein 62 Q0P6H9 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 61 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota TMEM63A HGNC:29118 transmembrane protein 63A O94886 Lysosome membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 4 11 lysosome membrane lysosome membrane Opisthokonta Eukaryota Eukaryota TMEM63B HGNC:17735 transmembrane protein 63B Q5T3F8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 4 11 plasma membrane plasma membrane Opisthokonta Eukaryota Eukaryota TMEM63C HGNC:23787 transmembrane protein 63C Q9P1W3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 5 11 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota Eukaryota TMEM64 HGNC:25441 transmembrane protein 64 Q6YI46 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 13 7 golgi apparatus membrane golgi apparatus membrane Euteleostomi Eukaryota Cell.Organisms TMEM65 HGNC:25203 transmembrane protein 65 Q6PI78 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 10 4 mitochondrion membrane mitochondrion membrane Bilateria Eukaryota Eukaryota TMEM66 HGNC:28789 transmembrane protein 66 Q96BY9 Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota TMEM67 HGNC:28396 transmembrane protein 67 Q5HYA8 Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). Plasma membrane (GO:0005886) endoplasmic reticulum membrane 39 7 cytoplasm. endoplasmic reticulum membrane. plasma membrane multiple Bilateria Eukaryota Eukaryota TMEM68 HGNC:26510 transmembrane protein 68 Q96MH6 Membrane; Multi-pass membrane protein (Potential). mitochondrion 11 1 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms TMEM69 HGNC:28035 transmembrane protein 69 Q5SWH9 Membrane; Multi-pass membrane protein (Potential). plasma membrane 18 5 plasma membrane plasma membrane Tetrapoda Deuterostomia Cell.Organisms TMEM70 HGNC:26050 transmembrane protein 70 Q9BUB7 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 16582907 mitochondrion membrane 100 2 mitochondrion. mitochondrion membrane multiple Theria Eukaryota Eukaryota TMEM71 HGNC:26572 transmembrane protein 71 Q6P5X7 Membrane; Multi-pass membrane protein (Potential). nucleus 20 2 nucleus nucleus Theria Theria Euteleostomi TMEM72 HGNC:31658 transmembrane protein 72 A0PK05 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 43 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Eumetazoa TMEM74 HGNC:26409 transmembrane protein 74 Q96NL1 Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. secreted 12 2 lysosome membrane lysosome membrane Tetrapoda Euteleostomi Bilateria TMEM74B HGNC:15893 transmembrane protein 74B Q9NUR3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 16 2 plasma membrane plasma membrane Theria Theria Chordata TMEM78 HGNC:32307 transmembrane protein 78 Q5T7P6 Membrane; Multi-pass membrane protein (Potential). cytoplasm 48 2 cytoplasm cytoplasm Human Human Opisthokonta TMEM79 HGNC:28196 transmembrane protein 79 Q9BSE2 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021); Nucleus (GO:0005634) ,17081983 plasma membrane 81 5 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa TMEM80 HGNC:27453 transmembrane protein 80 Q96HE8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 48 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Amniota Eumetazoa TMEM81 HGNC:32349 transmembrane protein 81 Q6P7N7 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 41 1 plasma membrane plasma membrane Amniota Euteleostomi Euteleostomi TMEM82 HGNC:32350 transmembrane protein 82 A0PJX8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 57 9 plasma membrane plasma membrane Tetrapoda Euteleostomi Craniata TMEM86A HGNC:26890 transmembrane protein 86A Q8N2M4 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 60 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Cell.Organisms Cell.Organisms TMEM86B HGNC:28448 transmembrane protein 86B Q8N661 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 49 8 cytoplasm cytoplasm Mammalia Opisthokonta Cell.Organisms TMEM87A HGNC:24522 transmembrane protein 87A Q8NBN3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 6 7 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota Eukaryota TMEM87B HGNC:25913 transmembrane protein 87B Q96K49 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 9 7 golgi apparatus membrane golgi apparatus membrane Opisthokonta Eukaryota Eukaryota TMEM88 HGNC:32371 transmembrane protein 88 Q6PEY1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 68 2 plasma membrane plasma membrane Amniota Euteleostomi Euteleostomi TMEM88B HGNC:37099 transmembrane protein 88B A6NKF7 Membrane; Multi-pass membrane protein (Potential). plasma membrane 67 2 plasma membrane plasma membrane Human Eutheria Eutheria TMEM89 HGNC:32372 transmembrane protein 89 A2RUT3 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) secreted 88 1 secreted secreted Eutheria Eutheria Eutheria TMEM8A HGNC:17205 transmembrane protein 8A Q9HCN3 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11006113 plasma membrane 18 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa TMEM8B HGNC:21427 transmembrane protein 8B A6NDV4 Isoform 2: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasm (Probable). Nucleus (Probable). Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 15498789,15498789 plasma membrane 20 7 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus. plasma membrane multiple Euteleostomi Eukaryota Eukaryota TMEM8C HGNC:33778 transmembrane protein 8C A6NI61 Membrane; Multi-pass membrane protein (Potential). plasma membrane 86 5 plasma membrane plasma membrane Amniota Euteleostomi Holozoa TMEM9 HGNC:18823 transmembrane protein 9 Q9P0T7 Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021); Endosome (GO:0005768); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 12359240,12359240,12359240,12359240 plasma membrane 28 1 cytoplasm. endosome. endosome membrane. lysosome. lysosome membrane multiple Deuterostomia Bilateria Eumetazoa TMEM91 HGNC:32393 transmembrane protein 91 Q6ZNR0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 92 2 plasma membrane plasma membrane Eukaryota Cell.Organisms Metazoa TMEM92 HGNC:26579 transmembrane protein 92 Q6UXU6 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 40 1 plasma membrane plasma membrane Theria Theria Mammalia TMEM95 HGNC:27898 transmembrane protein 95 Q3KNT9 Membrane; Single-pass type I membrane protein (Potential). secreted 68 1 secreted secreted Eutheria Eutheria Eutheria TMEM97 HGNC:28106 transmembrane protein 97 Q5BJF2 Nucleus membrane. Rough endoplasmic reticulum. Cell membrane. Lysosome. Membrane; Multi-pass membrane protein (Potential). Note=Localized in sterol-depleted cells at cell membrane and in lysosomes. Cytoplasm (GO:0005737) 15375745 endoplasmic reticulum membrane 17 4 cytoplasm. endoplasmic reticulum. lysosome multiple Euteleostomi Eukaryota NA TMEM98 HGNC:24529 transmembrane protein 98 Q9Y2Y6 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 33 1 plasma membrane plasma membrane Euteleostomi Deuterostomia Bilateria TMEM99 HGNC:28305 transmembrane protein 99 Q8N816 Membrane; Multi-pass membrane protein (Potential). secreted 76 4 n/a n/a Human Human Primates TMEM9B HGNC:1168 TMEM9 domain family, member B Q9NQ34 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 29 1 plasma membrane plasma membrane Amniota Bilateria Eumetazoa TMF1 HGNC:11870 TATA element modulatory factor 1 P82094 Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures localized at the tips of cisternae. Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12044884,12044884,17081983 cytoplasm 5 0 cytoplasm. golgi apparatus. nucleus multiple Deuterostomia Eukaryota Eukaryota TMIE HGNC:30800 transmembrane inner ear Q8NEW7 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 19 1 plasma membrane plasma membrane Euteleostomi Bilateria Bilateria TMIGD1 HGNC:32431 transmembrane and immunoglobulin domain containing 1 Q6UXZ0 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 16 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Metazoa TMIGD2 HGNC:28324 transmembrane and immunoglobulin domain containing 2 Q96BF3 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Homininae Eutheria Boreoeutheria TMLHE HGNC:18308 trimethyllysine hydroxylase, epsilon Q9NVH6 Mitochondrion matrix. Mitochondrion (GO:0005739) 11431483 mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Opisthokonta NA TMOD1 HGNC:11871 tropomodulin 1 P28289 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 7962203,8262158,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms TMOD2 HGNC:11872 tropomodulin 2 (neuronal) Q9NZR1 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) cytoplasm 50 0 cytoplasm cytoplasm Theria Amniota Cell.Organisms TMOD3 HGNC:11873 tropomodulin 3 (ubiquitous) Q9NYL9 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) 12707310,17081983 cytoplasm 53 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms TMOD4 HGNC:11874 tropomodulin 4 (muscle) Q9NZQ9 Cytoplasm, cytoskeleton. Cytoskeleton (GO:0005856) cytoplasm 100 0 cytoplasm cytoplasm Eutheria Euteleostomi Eukaryota TMPO HGNC:11875 thymopoietin P42166 Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus. Nuclear membrane (GO:0005635);Nuclear membrane (GO:0005635); Nucleus (GO:0005634);Nucleus (GO:0005634);Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8530026/8530026,15561729/8530026,15561729/15598749,17081983,17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus. nucleus membrane multiple Theria Theria Bilateria TMPPE HGNC:33865 transmembrane protein with metallophosphoesterase domain Q6ZT21 Membrane; Multi-pass membrane protein (Potential). plasma membrane 25 5 plasma membrane plasma membrane Human Cell.Organisms Cell.Organisms TMPRSS11A HGNC:27954 transmembrane protease, serine 11A Q6ZMR5 Membrane; Single-pass type II membrane protein (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15095404,15095404 secreted 24 1 cytoplasm. nucleus multiple Mammalia Chordata Cell.Organisms TMPRSS11B HGNC:25398 transmembrane protease, serine 11B Q86T26 Membrane; Single-pass type II membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 28 1 plasma membrane plasma membrane Mammalia Mammalia Cell.Organisms TMPRSS11BNL HGNC:37262 TMPRSS11B N-terminal like B3KVV0 Membrane; Single-pass membrane protein (Potential). plasma membrane 43 1 plasma membrane plasma membrane NA NA Amniota TMPRSS11D HGNC:24059 transmembrane protease, serine 11D O60235 Cell membrane; Single-pass type II membrane protein. Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11326745,11326745 endoplasmic reticulum membrane 32 1 cytoplasm. plasma membrane multiple Mammalia Mammalia Cell.Organisms TMPRSS11E HGNC:24465 transmembrane protease, serine 11E Q9UL52 Cell membrane; Single-pass type II membrane protein (By similarity). Transmembrane protease serine 11E catalytic chain: Secreted (By similarity). Note=Activated by cleavage and secreted (By similarity). secreted 28 1 secreted secreted Theria Amniota Cell.Organisms TMPRSS11F HGNC:29994 transmembrane protease, serine 11F Q6ZWK6 Membrane; Single-pass type II membrane protein (Potential). secreted 27 1 secreted secreted Mammalia Mammalia Cell.Organisms TMPRSS12 HGNC:28779 transmembrane (C-terminal) protease, serine 12 Q86WS5 Membrane; Single-pass membrane protein (Potential). plasma membrane 25 1 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms TMPRSS13 HGNC:29808 transmembrane protease, serine 13 Q9BYE2 Membrane; Single-pass type II membrane protein (Potential). Extracellular (GO:0005576) 11267681 secreted 28 1 secreted secreted Amniota Euteleostomi Cell.Organisms TMPRSS15 HGNC:9490 transmembrane protease, serine 15 P98073 Membrane; Single-pass type II membrane protein (Probable). secreted 27 1 secreted secreted Tetrapoda Chordata Cell.Organisms TMPRSS2 HGNC:11876 transmembrane protease, serine 2 O15393 Cell membrane; Single-pass type II membrane protein. Transmembrane protease serine 2 catalytic chain: Secreted. Note=Activated by cleavage and secreted. Plasma membrane (GO:0005886) 10485450 endoplasmic reticulum membrane 34 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms TMPRSS3 HGNC:11877 transmembrane protease, serine 3 P57727 Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 11068177,10825129,12393794 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. plasma membrane multiple Amniota Chordata Cell.Organisms TMPRSS4 HGNC:11878 transmembrane protease, serine 4 Q9NRS4 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 10825129 secreted 27 1 plasma membrane plasma membrane Deuterostomia Eukaryota Cell.Organisms TMPRSS5 HGNC:14908 transmembrane protease, serine 5 Q9H3S3 Cell membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 11741986 secreted 32 1 plasma membrane plasma membrane Mammalia Euteleostomi Cell.Organisms TMPRSS6 HGNC:16517 transmembrane protease, serine 6 Q8IU80 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 12149247 plasma membrane 100 1 plasma membrane plasma membrane Tetrapoda Bilateria Cell.Organisms TMPRSS7 HGNC:30846 transmembrane protease, serine 7 Q7RTY8 Cell membrane; Single-pass type II membrane protein (By similarity). plasma membrane 87 1 plasma membrane plasma membrane Amniota Euteleostomi Cell.Organisms TMPRSS9 HGNC:30079 transmembrane protease, serine 9 Q7Z410 Cell membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 12886014 plasma membrane 100 1 plasma membrane plasma membrane Bilateria Opisthokonta Cell.Organisms TMSB10 HGNC:11879 thymosin beta 10 P63313 Cytoplasm, cytoskeleton. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1582498,1582498 cytoplasm 72 0 cytoplasm. nucleus multiple Theria Deuterostomia Metazoa TMSB15A HGNC:30744 thymosin beta 15a P0CG34 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737) cytoplasm 63 0 cytoplasm cytoplasm Euarchontoglires Mammalia NA TMSB15B HGNC:28612 thymosin beta 15B P0CG35 Cytoplasm, cytoskeleton (By similarity). cytoplasm 63 0 cytoplasm cytoplasm Euarchontoglires Mammalia Opisthokonta TMSB4X HGNC:11881 thymosin beta 4, X-linked P62328 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 6838210 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa TMSB4Y HGNC:11882 thymosin beta 4, Y-linked O14604 Cytoplasm, cytoskeleton (By similarity). cytoplasm 92 0 cytoplasm cytoplasm Human Human Metazoa TMTC1 HGNC:24099 transmembrane and tetratricopeptide repeat containing 1 Q8IUR5 Membrane; Multi-pass membrane protein (Potential). nucleus 8 11 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms TMTC2 HGNC:25440 transmembrane and tetratricopeptide repeat containing 2 Q8N394 Membrane; Multi-pass membrane protein (Potential). mitochondrion 13 13 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms TMTC3 HGNC:26899 transmembrane and tetratricopeptide repeat containing 3 Q6ZXV5 Membrane; Multi-pass membrane protein (Potential). nucleus 9 13 nucleus nucleus Deuterostomia Bilateria Cell.Organisms TMTC4 HGNC:25904 transmembrane and tetratricopeptide repeat containing 4 Q5T4D3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) nucleus 7 13 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms TMUB1 HGNC:21709 transmembrane and ubiquitin-like domain containing 1 Q9BVT8 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Nucleus. Note=Predominantly nuclear during growth arrest (By similarity). Actively exported from the nucleus in dividing cells. Integral to membrane (GO:0016021) golgi apparatus membrane 55 3 cytoplasm. nucleus multiple Theria Euteleostomi Bilateria TMUB2 HGNC:28459 transmembrane and ubiquitin-like domain containing 2 Q71RG4 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 44 3 golgi apparatus membrane golgi apparatus membrane Human Human Bilateria TMX1 HGNC:15487 thioredoxin-related transmembrane protein 1 Q9H3N1 Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Note=Predominantly found in the endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11152479,11152479,11152479,15598749 endoplasmic reticulum 19 2 endoplasmic reticulum. mitochondrion. plasma membrane multiple Bilateria Eukaryota Cell.Organisms TMX2 HGNC:30739 thioredoxin-related transmembrane protein 2 Q9Y320 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum 28 3 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms TMX3 HGNC:24718 thioredoxin-related transmembrane protein 3 Q96JJ7 Endoplasmic reticulum membrane; Single-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Cell.Organisms TMX4 HGNC:25237 thioredoxin-related transmembrane protein 4 Q9H1E5 Membrane; Single-pass type I membrane protein (Potential). endoplasmic reticulum membrane 16 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Eukaryota TNC HGNC:5318 tenascin C P24821 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 1704365,8548761 secreted 100 0 secreted secreted Bilateria Bilateria Cell.Organisms TNF HGNC:11892 tumor necrosis factor P01375 Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 8597870,8597870 secreted 47 1 plasma membrane. secreted multiple Theria Euteleostomi NA TNFAIP1 HGNC:11894 tumor necrosis factor, alpha-induced protein 1 (endothelial) Q13829 Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes. nucleus 65 0 cytoplasm. endosome. nucleus multiple Euteleostomi Euteleostomi NA TNFAIP2 HGNC:11895 tumor necrosis factor, alpha-induced protein 2 Q03169 Extracellular (GO:0005576) 1374453 nucleus 76 0 secreted secreted Euteleostomi Euteleostomi Metazoa TNFAIP3 HGNC:11896 tumor necrosis factor, alpha-induced protein 3 P21580 Cytoplasm. Nucleus. Lysosome. A20p50: Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11009421,17081983, nucleus 51 0 cytoplasm. lysosome. nucleus multiple Mammalia Deuterostomia Metazoa TNFAIP6 HGNC:11898 tumor necrosis factor, alpha-induced protein 6 P98066 Extracellular (GO:0005576) 1730767,14718574 secreted 21 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms TNFAIP8 HGNC:17260 tumor necrosis factor, alpha-induced protein 8 O95379 Cytoplasm. Cytoplasm (GO:0005737) 14724590 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa TNFAIP8L1 HGNC:28279 tumor necrosis factor, alpha-induced protein 8-like 1 Q8WVP5 cytoplasm 46 0 cytoplasm cytoplasm Amniota Euteleostomi Holozoa TNFAIP8L2 HGNC:26277 tumor necrosis factor, alpha-induced protein 8-like 2 Q6P589 cytoplasm 43 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa TNFAIP8L3 HGNC:20620 tumor necrosis factor, alpha-induced protein 8-like 3 Q5GJ75 cytoplasm 51 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Holozoa TNFRSF10A HGNC:11904 tumor necrosis factor receptor superfamily, member 10a O00220 Membrane; Single-pass type I membrane protein. Integral to membrane (GO:0016021) secreted 20 1 secreted secreted Euarchontoglires Mammalia Holozoa TNFRSF10B HGNC:11905 tumor necrosis factor receptor superfamily, member 10b O14763 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 9311998 secreted 19 2 plasma membrane plasma membrane Homininae Euteleostomi Holozoa TNFRSF10C HGNC:11906 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain O14798 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9314565,11024459,11024459 plasma membrane 29 1 cytoplasm. nucleus. plasma membrane multiple Homininae Euarchontoglires Holozoa TNFRSF10D HGNC:11907 tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain Q9UBN6 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9430226,10754286,10754286 secreted 15 2 cytoplasm. nucleus. plasma membrane multiple Catarrhini Catarrhini Holozoa TNFRSF11A HGNC:11908 tumor necrosis factor receptor superfamily, member 11a, NFKB activator Q9Y6Q6 Membrane; Single-pass type I membrane protein (Potential). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11675352, secreted 19 1 cytoplasm cytoplasm Amniota Amniota Holozoa TNFRSF11B HGNC:11909 tumor necrosis factor receptor superfamily, member 11b O00300 Secreted. Extracellular (GO:0005576) 11035950 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Holozoa TNFRSF12A HGNC:18152 tumor necrosis factor receptor superfamily, member 12A Q9NP84 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10551889 secreted 29 1 plasma membrane plasma membrane Mammalia Tetrapoda Tetrapoda TNFRSF13B HGNC:18153 tumor necrosis factor receptor superfamily, member 13B O14836 Membrane; Single-pass type III membrane protein. Plasma membrane (GO:0005886) 10881172 secreted 100 1 plasma membrane plasma membrane NA NA Amniota TNFRSF13C HGNC:17755 tumor necrosis factor receptor superfamily, member 13C Q96RJ3 Membrane; Single-pass type III membrane protein (Probable). Plasma membrane (GO:0005886) 11869903,11509692 plasma membrane 62 1 plasma membrane plasma membrane Eutheria Eutheria Eutheria TNFRSF14 HGNC:11912 tumor necrosis factor receptor superfamily, member 14 Q92956 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 9162061 secreted 23 2 plasma membrane plasma membrane Euarchontoglires Deuterostomia Eukaryota TNFRSF17 HGNC:11913 tumor necrosis factor receptor superfamily, member 17 Q02223 Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures. Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 8527407,10903733,10903733 secreted 77 1 endomembrane system. golgi apparatus. plasma membrane multiple Mammalia Mammalia Opisthokonta TNFRSF18 HGNC:11914 tumor necrosis factor receptor superfamily, member 18 Q9Y5U5 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Plasma membrane (GO:0005886); Cell surface (GO:0009986) 9177197,17220876 secreted 26 1 plasma membrane. secreted multiple Amniota Amniota Deuterostomia TNFRSF19 HGNC:11915 tumor necrosis factor receptor superfamily, member 19 Q9NS68 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 10764796 secreted 100 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eumetazoa TNFRSF1A HGNC:11916 tumor necrosis factor receptor superfamily, member 1A P19438 Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Isoform 4: Secreted. Note=Lacks a Golgi- retention motif, is not membrane bound and therefore is secreted. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11985495,12887920,11985495,17255933,16680093 secreted 19 1 endoplasmic reticulum. golgi apparatus. golgi apparatus membrane. plasma membrane. secreted multiple Amniota Eukaryota Eukaryota TNFRSF1B HGNC:11917 tumor necrosis factor receptor superfamily, member 1B P20333 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tumor necrosis factor-binding protein 2: Secreted. Plasma membrane (GO:0005886) 10950109 secreted 24 1 plasma membrane. secreted multiple Amniota Euteleostomi Holozoa TNFRSF21 HGNC:13469 tumor necrosis factor receptor superfamily, member 21 O75509 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886) 11753679 secreted 18 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa TNFRSF25 HGNC:11910 tumor necrosis factor receptor superfamily, member 25 Q93038 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: Secreted. Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted. Plasma membrane (GO:0005886) 9052839,8875942 plasma membrane 25 1 plasma membrane. secreted multiple Amniota Amniota Holozoa TNFRSF4 HGNC:11918 tumor necrosis factor receptor superfamily, member 4 P43489 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 11929124 secreted 24 1 plasma membrane plasma membrane Theria Theria Holozoa TNFRSF6B HGNC:11921 tumor necrosis factor receptor superfamily, member 6b, decoy O95407 Secreted. Extracellular (GO:0005576); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 12471113,12794752,10655513 secreted 100 0 cytoplasm. endoplasmic reticulum. secreted multiple NA NA Holozoa TNFRSF8 HGNC:11923 tumor necrosis factor receptor superfamily, member 8 P28908 Isoform Long: Cell membrane; Single-pass type I membrane protein. Isoform Short: Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Extracellular (GO:0005576) 11754357,1310894,15265955,2537734,12557237,15033921,8839832,11754357,14726963,11986285,2537734,15033921 secreted 20 1 cytoplasm. plasma membrane. secreted multiple Eutheria Amniota Euteleostomi TNFRSF9 HGNC:11924 tumor necrosis factor receptor superfamily, member 9 Q07011 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10604232,11970964,11970964 plasma membrane 25 1 plasma membrane. secreted multiple Amniota Euteleostomi Holozoa TNFSF10 HGNC:11925 tumor necrosis factor (ligand) superfamily, member 10 P50591 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8777713,8663110,17081983 endoplasmic reticulum membrane 19 1 nucleus. plasma membrane multiple Amniota Euteleostomi Eumetazoa TNFSF11 HGNC:11926 tumor necrosis factor (ligand) superfamily, member 11 O14788 Isoform 1: Cell membrane; Single-pass type II membrane protein. Isoform 3: Cell membrane; Single-pass type II membrane protein. Isoform 2: Cytoplasm (By similarity). Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted (By similarity). Plasma membrane (GO:0005886);Extracellular (GO:0005576) 9312132/10708588 plasma membrane 18 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Eumetazoa TNFSF12 HGNC:11927 tumor necrosis factor (ligand) superfamily, member 12 O43508 Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted. Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576);Plasma membrane (GO:0005886) 15604260,9405449/15604260 plasma membrane 26 0 plasma membrane. secreted multiple NA NA Eumetazoa TNFSF13 HGNC:11928 tumor necrosis factor (ligand) superfamily, member 13 O75888 Secreted. Plasma membrane (GO:0005886);Golgi apparatus (GO:0005794); Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10706119/11571266,11571266,10706119 secreted 100 1 golgi apparatus. plasma membrane. secreted multiple Mammalia Euteleostomi Eumetazoa TNFSF13B HGNC:11929 tumor necrosis factor (ligand) superfamily, member 13b Q9Y275 Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10398604,10359578,10661873,10359578,10661873,11827482 secreted 16 1 plasma membrane. secreted multiple Amniota Euteleostomi Chordata TNFSF14 HGNC:11930 tumor necrosis factor (ligand) superfamily, member 14 O43557 Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted. Isoform 2: Cytoplasm. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11035077,11035077 secreted 30 2 cytoplasm. plasma membrane. secreted multiple Mammalia Mammalia Chordata TNFSF15 HGNC:11931 tumor necrosis factor (ligand) superfamily, member 15 O95150 Membrane; Single-pass type II membrane protein (Probable). Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10597252,11911831 secreted 65 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Eumetazoa TNFSF18 HGNC:11932 tumor necrosis factor (ligand) superfamily, member 18 Q9UNG2 Cell membrane; Single-pass type II membrane protein. Cytoplasm (GO:0005737) 14521928 plasma membrane 100 2 cytoplasm. plasma membrane multiple Eutheria Mammalia Mammalia TNFSF4 HGNC:11934 tumor necrosis factor (ligand) superfamily, member 4 P23510 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 1996093 secreted 47 1 plasma membrane plasma membrane Amniota Amniota Amniota TNFSF8 HGNC:11938 tumor necrosis factor (ligand) superfamily, member 8 P32971 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 7528856 secreted 61 1 plasma membrane plasma membrane Amniota Amniota Amniota TNFSF9 HGNC:11939 tumor necrosis factor (ligand) superfamily, member 9 P41273 Membrane; Single-pass type II membrane protein. Plasma membrane (GO:0005886) 8088337 secreted 48 1 plasma membrane plasma membrane Mammalia Mammalia Mammalia TNIK HGNC:30765 TRAF2 and NCK interacting kinase Q9UKE5 Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression. Cytoplasm (GO:0005737) 15342639 cytoplasm 49 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Cell.Organisms TNIP1 HGNC:16903 TNFAIP3 interacting protein 1 Q15025 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9923610,12965196,12220502,12220502,11090181 cytoplasm 17 0 cytoplasm. nucleus multiple Chordata Chordata Metazoa TNIP2 HGNC:19118 TNFAIP3 interacting protein 2 Q8NFZ5 Cytoplasm. Nucleus (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11390377,12595760,12753905,12595760 nucleus 20 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Chordata TNIP3 HGNC:19315 TNFAIP3 interacting protein 3 Q96KP6 cytoplasm 18 0 cytoplasm cytoplasm Amniota Amniota Deuterostomia TNK1 HGNC:11940 tyrosine kinase, non-receptor, 1 Q13470 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 10873601,10873601 cytoplasm 22 1 cytoplasm cytoplasm Eutheria Tetrapoda Cell.Organisms TNK2 HGNC:19297 tyrosine kinase, non-receptor, 2 Q07912 Cell membrane. Nucleus. Endosome. Cell junction, adherens junction (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Membrane, clathrin- coated pit. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus. Co-localizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent. Vesicle (None); Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11278436,11278436,8647288,14733946,17081983,14733946 cytoplasm 26 0 cytoplasm. endosome. nucleus multiple Bilateria Bilateria Cell.Organisms TNKS HGNC:11941 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase O95271 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere. Nucleus, nuclear pore complex. Chromosome, telomere (Potential). Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1. Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endosome (GO:0005768) 11802774,10988299,10523501,11802774,11278563 cytoplasm 17 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms TNKS1BP1 HGNC:19081 tankyrase 1 binding protein 1, 182kDa Q9C0C2 Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11854288,17081983,11854288,17081983 cytoplasm 17 0 cytoplasm. nucleus multiple Amniota Amniota Euteleostomi TNKS2 HGNC:15677 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Q9H2K2 Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere (Potential). Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Endosome (GO:0005768) 11454873,11454873,11739745,11278563,11278563 nucleus 22 0 cytoplasm. endosome. golgi apparatus. nucleus multiple Deuterostomia Cell.Organisms Cell.Organisms TNMD HGNC:17757 tenomodulin Q9H2S6 Membrane; Single-pass type II membrane protein (Potential). Plasma membrane (GO:0005886) 11162640 secreted 47 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata TNN HGNC:22942 tenascin N Q9UQP3 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) secreted 100 0 secreted secreted Bilateria Bilateria Cell.Organisms TNNC1 HGNC:11943 troponin C type 1 (slow) P63316 cytoplasm 40 0 cytoplasm cytoplasm Chordata Chordata Cell.Organisms TNNC2 HGNC:11944 troponin C type 2 (fast) P02585 Extracellular (GO:0005576) 16188874 cytoplasm 41 0 secreted secreted Chordata Chordata Cell.Organisms TNNI1 HGNC:11945 troponin I type 1 (skeletal, slow) P19237 Cytoplasm (GO:0005737) 1934363 nucleus 73 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria TNNI2 HGNC:11946 troponin I type 2 (skeletal, fast) P48788 Cytoplasm (GO:0005737) 10077564 nucleus 71 0 cytoplasm cytoplasm Euteleostomi Bilateria Bilateria TNNI3 HGNC:11947 troponin I type 3 (cardiac) P19429 nucleus 74 0 nucleus nucleus Tetrapoda Tetrapoda Bilateria TNNI3K HGNC:19661 TNNI3 interacting kinase Q59H18 Nucleus. Cytoplasm. Note=Expressed at lower levels in the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12721663,12721663 cytoplasm 90 0 cytoplasm. nucleus multiple NA NA Cell.Organisms TNNT1 HGNC:11948 troponin T type 1 (skeletal, slow) P13805 Cytoplasm (GO:0005737) 10451243,10601315 nucleus 60 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Bilateria TNNT2 HGNC:11949 troponin T type 2 (cardiac) P45379 Cytoplasm (GO:0005737) cytoplasm 15 0 cytoplasm cytoplasm Human Euteleostomi Bilateria TNNT3 HGNC:11950 troponin T type 3 (skeletal, fast) P45378 Extracellular (GO:0005576) 16188874 cytoplasm 0 0 secreted secreted Eutheria Chordata Bilateria TNP1 HGNC:11951 transition protein 1 (during histone to protamine replacement) P09430 Nucleus. Chromosome. Nucleus (GO:0005634) 11315969 nucleus 100 0 nucleus nucleus Theria Theria Eutheria TNP2 HGNC:11952 transition protein 2 (during histone to protamine replacement) Q05952 Nucleus. Chromosome. Nucleus (GO:0005634) 9809674 nucleus 100 0 nucleus nucleus Eutheria Eutheria Boreoeutheria TNPO1 HGNC:6401 transportin 1 Q92973 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nuclear membrane (GO:0005635); Centrosome (GO:0005813) 7604027,9298975,9144189,7604027,9144189,9298975,15561729 cytoplasm 21 0 cytoplasm. nucleus. nucleus membrane multiple Eukaryota Eukaryota Eukaryota TNPO2 HGNC:19998 transportin 2 O14787 Cytoplasm (By similarity). Nucleus (By similarity). Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737) 9298975,14981248,9298975,14981248 cytoplasm 20 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota TNPO3 HGNC:17103 transportin 3 Q9Y5L0 Cytoplasm. Nucleus. Nucleus (GO:0005634) nucleus 43 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota TNR HGNC:11953 tenascin R Q92752 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Nucleus (GO:0005634) 8626505,17081983 secreted 100 0 nucleus. secreted multiple Bilateria Bilateria Cell.Organisms TNRC18 HGNC:11962 trinucleotide repeat containing 18 O15417 nucleus 47 0 nucleus nucleus Deuterostomia Bilateria Eukaryota TNRC6A HGNC:11969 trinucleotide repeat containing 6A Q8NDV7 Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11950943,15494374,11950943,15494374 cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa TNRC6B HGNC:29190 trinucleotide repeat containing 6B Q9UPQ9 Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs). cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Metazoa TNRC6C HGNC:29318 trinucleotide repeat containing 6C Q9HCJ0 cytoplasm 38 0 cytoplasm cytoplasm Deuterostomia Bilateria Metazoa TNS1 HGNC:11973 tensin 1 Q9HBL0 Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1- dependent manner. Plasma membrane (GO:0005886) 11023826 secreted 44 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota TNS3 HGNC:21616 tensin 3 Q68CZ2 Cell junction, focal adhesion. Integral to membrane (GO:0016021) secreted 100 0 secreted secreted Bilateria Bilateria Eukaryota TNS4 HGNC:24352 tensin 4 Q8IZW8 Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Plasma membrane (GO:0005886) 12154022 secreted 39 0 cytoplasm cytoplasm Eutheria Mammalia Holozoa TNXB HGNC:11976 tenascin XB P22105 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 7686164 secreted 100 0 secreted secreted Bilateria Bilateria NA TOB1 HGNC:11979 transducer of ERBB2, 1 P50616 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11163184,15235587,12782279,15235587,12782279,12782279 cytoplasm 59 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota TOB2 HGNC:11980 transducer of ERBB2, 2 Q14106 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10602502,10602502 cytoplasm 100 0 cytoplasm. nucleus multiple Amniota Deuterostomia Eukaryota TOE1 HGNC:15954 target of EGR1, member 1 (nuclear) Q96GM8 Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles. Nucleus (GO:0005634); Nucleolus (GO:0005730) 12562764,17081983,12562764 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota TOLLIP HGNC:16476 toll interacting protein Q9H0E2 Cytoplasm (Probable). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 10854325,10854325 cytoplasm 12 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota TOM1 HGNC:11982 target of myb1 (chicken) O60784 Cytoplasm (Probable). Membrane; Peripheral membrane protein (Probable). Cytoplasm (GO:0005737); Endosome (GO:0005768) 14563850,14613930 golgi apparatus 7 0 cytoplasm. endosome multiple Euteleostomi Eukaryota Eukaryota TOM1L1 HGNC:11983 target of myb1 (chicken)-like 1 O75674 Golgi apparatus, Golgi stack. Endosome membrane (Potential). Cytoplasm (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=A small proportion is membrane-associated (By similarity). Endosome (GO:0005768); Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 11711534,10329004,15611048,11711534,10329004,11711534,10329004,15611048 golgi apparatus 15 0 cytoplasm. endosome. golgi apparatus. lysosome multiple Tetrapoda Tetrapoda Eukaryota TOM1L2 HGNC:11984 target of myb1-like 2 (chicken) Q6ZVM7 golgi apparatus 11 0 golgi apparatus golgi apparatus Euteleostomi Eukaryota Eukaryota TOMM20 HGNC:20947 translocase of outer mitochondrial membrane 20 homolog (yeast) Q15388 Mitochondrion outer membrane; Single-pass membrane protein (Potential). Mitochondrion (GO:0005739) 10548729,9748310,17510655 mitochondrion membrane 25 1 mitochondrion mitochondrion Bilateria Bilateria Opisthokonta TOMM20L HGNC:33752 translocase of outer mitochondrial membrane 20 homolog (yeast)-like Q6UXN7 Mitochondrion outer membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) mitochondrion membrane 37 1 mitochondrion membrane mitochondrion membrane Theria Opisthokonta Opisthokonta TOMM22 HGNC:18002 translocase of outer mitochondrial membrane 22 homolog (yeast) Q9NS69 Mitochondrion outer membrane; Single-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 10900208,17510655,15598749 mitochondrion membrane 91 1 mitochondrion mitochondrion Bilateria Bilateria Holozoa TOMM34 HGNC:15746 translocase of outer mitochondrial membrane 34 Q15785 Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 11913976,10101285,11913975,11913976,10101285,11913975,9324309 cytoplasm 36 0 cytoplasm. mitochondrion multiple Human Eukaryota Cell.Organisms TOMM40 HGNC:18001 translocase of outer mitochondrial membrane 40 homolog (yeast) O96008 Mitochondrion outer membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 10980201,15644312,17510655,15561729 mitochondrion membrane 100 0 mitochondrion. mitochondrion membrane multiple Eukaryota Eukaryota Eukaryota TOMM40L HGNC:25756 translocase of outer mitochondrial membrane 40 homolog (yeast)-like Q969M1 Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). mitochondrion membrane 96 0 mitochondrion membrane mitochondrion membrane Theria Euteleostomi Eukaryota TOMM5 HGNC:31369 translocase of outer mitochondrial membrane 5 homolog (yeast) Q8N4H5 Mitochondrion outer membrane; Single-pass membrane protein. mitochondrion membrane 100 1 mitochondrion membrane mitochondrion membrane Theria Euteleostomi Craniata TOMM6 HGNC:34528 translocase of outer mitochondrial membrane 6 homolog (yeast) Q96B49 Mitochondrion outer membrane. Mitochondrial membrane (GO:0005740) ,18331822, secreted 51 1 mitochondrion membrane mitochondrion membrane Theria Amniota Craniata TOMM7 HGNC:21648 translocase of outer mitochondrial membrane 7 homolog (yeast) Q9P0U1 Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion (GO:0005739) 12198123 mitochondrion membrane 100 1 mitochondrion. mitochondrion membrane multiple Bilateria Bilateria Eumetazoa TOMM70A HGNC:11985 translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) O94826 Mitochondrion outer membrane; Single-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 12200962,15598749 mitochondrion membrane 91 1 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms TONSL HGNC:7801 tonsoku-like, DNA repair protein Q96HA7 Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. nucleus 35 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms TOP1 HGNC:11986 topoisomerase (DNA) I P11387 Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11818025,15848144,15561729,11818025,12149243,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TOP1MT HGNC:29787 topoisomerase (DNA) I, mitochondrial Q969P6 Mitochondrion. Mitochondrion (GO:0005739) 11526219,15096574 mitochondrion 100 0 mitochondrion mitochondrion Eukaryota Eukaryota Cell.Organisms TOP2A HGNC:11989 topoisomerase (DNA) II alpha 170kDa P11388 Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm. Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776) 6267071,15034300,11790298,15635413,15561729 nucleus 88 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms TOP2B HGNC:11990 topoisomerase (DNA) II beta 180kDa Q02880 Cytoplasm. Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Kinetochore (GO:0000776); Cytoplasm (GO:0005737) 11395412,9795238,9743583,17081983,11927602,15635413,11790298,15561729,17081983 nucleus 96 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms TOP3A HGNC:11992 topoisomerase (DNA) III alpha Q13472 Nucleus (GO:0005634); Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 11406610,10734115,12209014,10710432,12209014,10739669 nucleus 31 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms TOP3B HGNC:11993 topoisomerase (DNA) III beta O95985 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11549288,9786843,10710432,11549288 nucleus 55 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms TOPAZ1 HGNC:24746 testis and ovary specific PAZ domain containing 1 Q8N9V7 Cytoplasm, cytosol (By similarity). cytoplasm 73 0 cytoplasm cytoplasm Amniota Euteleostomi Craniata TOPBP1 HGNC:17008 topoisomerase (DNA) II binding protein 1 Q92547 Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11756551,17006541,15635413 nucleus 10 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota TOPORS HGNC:21653 topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase Q9NS56 Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage. Nucleus (GO:0005634); Nucleoplasm (GO:0005654); Nucleolus (GO:0005730) 10352183,17081983,17290218,17290218 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota TOR1A HGNC:3098 torsin family 1, member A (torsin A) O14656 Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of the endoplasmic reticulum. The association with nuclear envelope is mediated by the interaction with TOR1AIP2. The Glu-303 del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmic reticulum. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 10814722,15028751,10814722,10871631,15028751,15147511,11405807,11940688,10871631,15028751 secreted 38 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Cell.Organisms Cell.Organisms TOR1AIP1 HGNC:29456 torsin A interacting protein 1 Q5JTV8 Nucleus inner membrane; Single-pass membrane protein (By similarity). Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 12061773,17081983,12061773 nucleus membrane 65 1 endoplasmic reticulum. nucleus multiple Amniota Chordata Eumetazoa TOR1AIP2 HGNC:24055 torsin A interacting protein 2 Q8NFQ8 Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane. Endoplasmic reticulum (GO:0005783) 15767459 nucleus membrane 51 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Theria Euteleostomi Eumetazoa TOR1B HGNC:11995 torsin family 1, member B (torsin B) O14657 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783); Perinuclear region (GO:0048471) 15147511,15147511 secreted 32 0 cytoplasm. endoplasmic reticulum multiple Tetrapoda Tetrapoda Cell.Organisms TOR2A HGNC:11996 torsin family 2, member A Q5JU69 Secreted (Probable). Extracellular (GO:0005576) 12910263 secreted 100 0 secreted secreted Human Euteleostomi Eumetazoa TOR3A HGNC:11997 torsin family 3, member A Q9H497 Cytoplasm. Endoplasmic reticulum. Endoplasmic reticulum (GO:0005783) 11863361 secreted 25 0 cytoplasm. endoplasmic reticulum multiple Human Euteleostomi Cell.Organisms TOR4A HGNC:25981 torsin family 4, member A Q9NXH8 Membrane; Single-pass membrane protein (Potential). Cytoplasm (GO:0005737) 17081983 secreted 14 1 cytoplasm cytoplasm Euteleostomi Euteleostomi Eumetazoa TOX HGNC:18988 thymocyte selection-associated high mobility group box O94900 Nucleus (By similarity). Nucleus (GO:0005634) 11850626 nucleus 93 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa TOX2 HGNC:16095 TOX high mobility group box family member 2 Q96NM4 Nucleus (By similarity). Nucleus (GO:0005634) 14764631 nucleus 88 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta TOX3 HGNC:11972 TOX high mobility group box family member 3 O15405 Nucleus (Probable). nucleus 45 0 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta TOX4 HGNC:20161 TOX high mobility group box family member 4 O94842 Nucleus (Probable). Note=Associated with chromatin. Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Theria Bilateria Eukaryota TP53 HGNC:11998 tumor protein p53 P04637 Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Isoform 1: Nucleus. Cytoplasm. Isoform 2: Nucleus. Cytoplasm. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Nucleus. Cytoplasm. Isoform 7: Nucleus. Cytoplasm. Isoform 8: Nucleus. Cytoplasm. Isoform 9: Cytoplasm. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Nucleolus (GO:0005730); Cytosol (GO:0005829); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) ,8623910,15855171,8639538,17268548,15580310,16753148,16616141,17170702,9194564,15604276,17347673,14966293,16319068,17139261,17098746,17879958,,12667443,15077116,15598749,11805286,15580310,16616141,17170702,,8623910,15855171,8639538,17268548,16753148,15604276,16319068,17139261,17369817,17098746,15355990,17879958, nucleus 38 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Bilateria Eukaryota TP53AIP1 HGNC:29984 tumor protein p53 regulated apoptosis inducing protein 1 Q9HCN2 Mitochondrion. Mitochondrion (GO:0005739) 11030628,12019168 mitochondrion 100 1 mitochondrion mitochondrion Homininae Homininae Homo TP53BP1 HGNC:11999 tumor protein p53 binding protein 1 Q12888 Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9748285,16395335,12446782,15364958,17081983,9748285,17081983 nucleus 100 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota TP53BP2 HGNC:12000 tumor protein p53 binding protein, 2 Q13625 Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/9748285,8668206,10498867,14985081/10498867 cytoplasm 25 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Cell.Organisms TP53I11 HGNC:16842 tumor protein p53 inducible protein 11 O14683 Membrane; Multi-pass membrane protein (Potential). Cytoplasm (GO:0005737); Integral to membrane (GO:0016021) 15225615, endoplasmic reticulum membrane 16 4 cytoplasm cytoplasm NA NA Eumetazoa TP53I13 HGNC:25102 tumor protein p53 inducible protein 13 Q8NBR0 Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential). Cytoplasm. Note=Associates with unknown subcellular structures in the cytoplasm. Cytoplasm (GO:0005737) 14767535 nucleus 41 1 cytoplasm cytoplasm Eutheria Tetrapoda Bilateria TP53I3 HGNC:19373 tumor protein p53 inducible protein 3 Q53FA7 Cytoplasm (GO:0005737) 10840161 cytoplasm 12 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms TP53INP1 HGNC:18022 tumor protein p53 inducible nuclear protein 1 Q96A56 Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. Nucleus (GO:0005634) 11511362 nucleus 54 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa TP53INP2 HGNC:16104 tumor protein p53 inducible nuclear protein 2 Q8IXH6 Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. Nucleus (GO:0005634) nucleus 55 0 cytoplasm. nucleus multiple Human Human Eumetazoa TP53RK HGNC:16197 TP53 regulating kinase Q96S44 Nucleus. Nucleus (GO:0005634) 11546806 nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms TP53TG3 HGNC:30759 TP53 target 3 Q9ULZ0 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10534768,10534768 secreted 72 0 cytoplasm. nucleus multiple Homininae Homininae Primates TP53TG3B HGNC:37202 TP53 target 3B Q9ULZ0 Cytoplasm. Nucleus. secreted 72 0 cytoplasm. nucleus multiple Homininae Homininae Primates TP53TG3C HGNC:42962 TP53 target 3C Q9ULZ0 Cytoplasm. Nucleus. secreted 72 0 cytoplasm. nucleus multiple NA NA Primates TP53TG3D HGNC:44657 TP53 target 3D Q9ULZ0 Cytoplasm. Nucleus. secreted 72 0 cytoplasm. nucleus multiple NA NA Primates TP53TG5 HGNC:15856 TP53 target 5 Q9Y2B4 Cytoplasm. Nucleus. Note=Cell cycle dependent intracellular localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10719363,10719363 nucleus 56 0 cytoplasm. nucleus multiple Amniota Amniota Amniota TP63 HGNC:15979 tumor protein p63 Q9H3D4 Nucleus. Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 11932750,12358808,9799226 nucleus 100 0 endoplasmic reticulum. nucleus multiple Deuterostomia Bilateria Eukaryota TP73 HGNC:12003 tumor protein p73 O15350 Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10391251,15070730,15070730 nucleus 50 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota TPBG HGNC:12004 trophoblast glycoprotein Q13641 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 7593330 secreted 16 1 plasma membrane plasma membrane Amniota Euteleostomi Holozoa TPBGL HGNC:44159 trophoblast glycoprotein-like P0DKB5 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 20 1 plasma membrane plasma membrane NA NA NA TPCN1 HGNC:18182 two pore segment channel 1 Q9ULQ1 Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10753632 vacuole membrane 13 12 endosome membrane. lysosome membrane. plasma membrane multiple Theria Eukaryota Cell.Organisms TPCN2 HGNC:20820 two pore segment channel 2 Q8NHX9 Lysosome membrane; Multi-pass membrane protein (By similarity). Note=Only the acidic lysosomal fraction is sensitive to NAADP (By similarity). vacuole membrane 12 13 vacuole membrane vacuole membrane Deuterostomia Eukaryota Eukaryota TPD52 HGNC:12005 tumor protein D52 P55327 nucleus 34 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa TPD52L1 HGNC:12006 tumor protein D52-like 1 Q16890 nucleus 43 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa TPD52L2 HGNC:12007 tumor protein D52-like 2 O43399 Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983/17081983,17081983 cytoplasm 37 0 cytoplasm. nucleus multiple Bilateria Bilateria Eumetazoa TPD52L3 HGNC:23382 tumor protein D52-like 3 Q96J77 cytoplasm 27 0 cytoplasm cytoplasm Eutheria Eutheria Eumetazoa TPGS1 HGNC:25058 tubulin polyglutamylase complex subunit 1 Q6ZTW0 Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes (By similarity). nucleus 34 0 cytoplasm cytoplasm Theria Deuterostomia Eumetazoa TPGS2 HGNC:24561 tubulin polyglutamylase complex subunit 2 Q68CL5 Cytoplasm, cytoskeleton (By similarity). nucleus 55 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta TPH1 HGNC:12008 tryptophan hydroxylase 1 P17752 Cytoplasm (GO:0005737) 10421874,10217286 cytoplasm 30 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms TPH2 HGNC:20692 tryptophan hydroxylase 2 Q8IWU9 cytoplasm 27 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms TPI1 HGNC:12009 triosephosphate isomerase 1 P60174 Cytoplasm (GO:0005737) 10655478,10677844,17081983 cytoplasm 54 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA TPK1 HGNC:17358 thiamin pyrophosphokinase 1 Q9H3S4 cytoplasm 25 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms TPM1 HGNC:12010 tropomyosin 1 (alpha) P09493 Cytoplasm, cytoskeleton. Perinuclear region (GO:0048471); Cytoplasm (GO:0005737); Actin cytoskeleton (GO:0015629) 12527301,10978337,12594734 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms TPM2 HGNC:12011 tropomyosin 2 (beta) P07951 Cytoplasm, cytoskeleton. Cytoskeleton (GO:0005856); Extracellular (GO:0005576) 3865200,16188874 cytoplasm 100 0 cytoplasm. secreted multiple Bilateria Bilateria Eumetazoa TPM3 HGNC:12012 tropomyosin 3 P06753 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Cytosol (GO:0005829) 10807789,10216106,15822942,16263121 cytoplasm 100 0 cytoplasm. secreted multiple Bilateria Bilateria Holozoa TPM4 HGNC:12013 tropomyosin 4 P67936 Cytoplasm, cytoskeleton. Cytoskeleton (GO:0005856) 11782456 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Bilateria Eumetazoa TPMT HGNC:12014 thiopurine S-methyltransferase P51580 Cytoplasm. Cytoplasm (GO:0005737) 9177237,14987117 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms TPO HGNC:12015 thyroid peroxidase P07202 Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface. Plasma membrane (GO:0005886); Endoplasmic reticulum membrane (GO:0005789); Nuclear membrane (GO:0005635) 11916616,11916616,11916616 secreted 43 1 endoplasmic reticulum membrane. nucleus membrane. plasma membrane multiple Chordata Chordata Cell.Organisms TPP1 HGNC:2073 tripeptidyl peptidase I O14773 Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Lysosome (GO:0005764); Nucleus (GO:0005634) 12488460,9295267,17237767 secreted 18 0 lysosome. melanosome. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms TPP2 HGNC:12016 tripeptidyl peptidase II P29144 Cytoplasm. Nucleus. Note=Translocates to the nucleus in responce to gamma-irradiation. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12370345,10691692,8602240 secreted 15 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms TPPP HGNC:24164 tubulin polymerization promoting protein O94811 Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies. Cytoskeleton (GO:0005856); Microtubule cytoskeleton (GO:0015630) 11781156,17027006 cytoplasm 38 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TPPP2 HGNC:19293 tubulin polymerization-promoting protein family member 2 P59282 Cytoplasm (Probable). cytoplasm 50 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota TPPP3 HGNC:24162 tubulin polymerization-promoting protein family member 3 Q9BW30 Cytoplasm, cytoskeleton (Probable). nucleus 17 0 cytoplasm cytoplasm Theria Euteleostomi Eukaryota TPR HGNC:12017 translocated promoter region, nuclear basket protein P12270 Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nuclear envelope to the perinucleolar region. Detected in diffuse and discrete spheroidal intranuclear foci. Nucleocytoplasmic shuttling protein imported into the nucleus in a XPO1/CRM1- and Importin alpha/Importin beta receptor-dependent manner. Remains localized to the nuclear membrane after poliovirus (PV) infection. During mitosis, remains associated with the nuclear envelope until prometaphase. Associated with the mitotic spindle from late prometaphase until anaphase. Reorganized during mitosis in a viscous and dynamic nuclear-derived spindle matrix that embeds the microtubule spindle apparatus from pole to pole in a microtubule- independent manner. Recruited to the reforming nuclear envelope during telophase and cytokinesis. Detected at kinetochores during prometaphase (PubMed:18981471). Colocalizes with MAD2L1 in the spindle matrix but not at kinetochore (PubMed:19273613). Colocalizes with dynein, dynactin, tubulin at kinetochore during the metaphase-anaphase transition. Colocalizes with DYNLL1 at the mitotic spindle. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Nuclear membrane (GO:0005635) 7798308,11952838,17081983,9864356,11248057,11952838,17081983,11248057,15635413,12513910,15561729 cytoplasm 7 0 cytoplasm. nucleus. nucleus membrane multiple Opisthokonta Eukaryota Eukaryota TPRA1 HGNC:30413 transmembrane protein, adipocyte asscociated 1 Q86W33 Membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 58 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Bilateria Holozoa TPRG1 HGNC:24759 tumor protein p63 regulated 1 Q6ZUI0 cytoplasm 26 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota TPRG1L HGNC:27007 tumor protein p63 regulated 1-like Q5T0D9 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Note=Localized to presynaptic nerve terminals (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Metazoa TPRKB HGNC:24259 TP53RK binding protein Q9Y3C4 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12659830,12659830 cytoplasm 11 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota TPRN HGNC:26894 taperin Q4KMQ1 Cell projection, stereocilium (By similarity). Note=Localized prominently at the taper regions of hair cell stereocilia (By similarity). cytoplasm 48 0 cytoplasm cytoplasm Theria Euteleostomi Euteleostomi TPRX1 HGNC:32174 tetra-peptide repeat homeobox 1 Q8N7U7 Nucleus (Potential). Nucleus (GO:0005634) nucleus 22 0 nucleus nucleus Homininae Homininae Eukaryota TPSAB1 HGNC:12019 tryptase alpha/beta 1 Q15661 Secreted. Note=Released from the secretory granules upon mast cell activation (By similarity). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 7009736,8675637,11568008 secreted 100 0 cytoplasm. secreted multiple Mammalia Chordata Cell.Organisms TPSB2 HGNC:14120 tryptase beta 2 (gene/pseudogene) P20231 Secreted. Note=Released from the secretory granules upon mast cell activation. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 7009736,8675637,11568008 secreted 100 0 cytoplasm. secreted multiple Mammalia Chordata Cell.Organisms TPSD1 HGNC:14118 tryptase delta 1 Q9BZJ3 Secreted (By similarity). Note=Released from the secretory granules upon mast cell activation (By similarity). secreted 81 0 secreted secreted Human Human Cell.Organisms TPSG1 HGNC:14134 tryptase gamma 1 Q9NRR2 Membrane; Single-pass membrane protein (Potential). Plasma membrane (GO:0005886); Extracellular (GO:0005576) 10521469,12194977,12194977 secreted 41 0 secreted secreted Euarchontoglires Euarchontoglires Cell.Organisms TPST1 HGNC:12020 tyrosylprotein sulfotransferase 1 O60507 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 9501187 golgi apparatus membrane 52 0 golgi apparatus golgi apparatus Bilateria Cell.Organisms Cell.Organisms TPST2 HGNC:12021 tyrosylprotein sulfotransferase 2 O60704 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi lumen (GO:0005796) 9736702,9733778 golgi apparatus membrane 59 0 golgi apparatus golgi apparatus Tetrapoda Bilateria Cell.Organisms TPT1 HGNC:12022 tumor protein, translationally-controlled 1 P13693 Cytoplasm. Nucleus (GO:0005634); Extracellular (GO:0005576); Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856); Nucleolus (GO:0005730); Plasma membrane (GO:0005886); Mitochondrion (GO:0005739) 11598139,15319436,15162379,15162379,11790298,16730713,15598749 cytoplasm 100 0 cytoplasm. mitochondrion. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota TPTE HGNC:12023 transmembrane phosphatase with tensin homology P56180 Membrane; Multi-pass membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 11810268,14659893,11279206,14659893,14659893 cytoplasm 17 4 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Deuterostomia Eukaryota Eukaryota TPTE2 HGNC:17299 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Q6XPS3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Isoform 4: Cytoplasm. Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11716755,14659893,11716755,14659893 cytoplasm 18 4 cytoplasm. endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota TPX2 HGNC:1249 TPX2, microtubule-associated Q9ULW0 Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. Nucleus (GO:0005634); Microtubule (GO:0005874) 12177045,15561729 nucleus 48 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Opisthokonta TRA2A HGNC:16645 transformer 2 alpha homolog (Drosophila) Q13595 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) none,17081983,15598749,17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Tetrapoda Euteleostomi Cell.Organisms TRA2B HGNC:10781 transformer 2 beta homolog (Drosophila) P62995 Nucleus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 9212162,10749975,17081983,15635413,15598749,17081983 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Bilateria Eukaryota Cell.Organisms TRABD HGNC:28805 TraB domain containing Q9H4I3 plasma membrane 39 1 plasma membrane plasma membrane Bilateria Cell.Organisms Cell.Organisms TRABD2A HGNC:27013 TraB domain containing 2A Q86V40 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms TRABD2B HGNC:44200 TraB domain containing 2B A6NFA1 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane NA NA NA TRADD HGNC:12030 TNFRSF1A-associated via death domain Q15628 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 12045187,9916731,12045187,9916731,9916731 cytoplasm 34 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Theria Euteleostomi Chordata TRAF1 HGNC:12031 TNF receptor-associated factor 1 Q13077 Cytoplasm (GO:0005737) 8069916 cytoplasm 82 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Metazoa TRAF2 HGNC:12032 TNF receptor-associated factor 2 Q12933 Cytoplasm. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11909853,17081983,11909853 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota TRAF3 HGNC:12033 TNF receptor-associated factor 3 Q13114 Cytoplasm (Probable). Endosome (By similarity). Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. Cytoplasm (GO:0005737); Nuclear membrane (GO:0005635); Plasma membrane (GO:0005886) 11728344,10781837,10781837 cytoplasm 28 0 cytoplasm. mitochondrion. nucleus membrane multiple Deuterostomia Deuterostomia Eukaryota TRAF3IP1 HGNC:17861 TNF receptor-associated factor 3 interacting protein 1 Q8TDR0 Cytoplasm, cytoskeleton. Note=Microtubules. Cytoplasm (GO:0005737) 10791955 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TRAF3IP2 HGNC:1343 TRAF3 interacting protein 2 O43734 Cytoplasm (GO:0005737) 10903453 nucleus 73 0 cytoplasm cytoplasm Chordata Chordata Bilateria TRAF3IP3 HGNC:30766 TRAF3 interacting protein 3 Q9Y228 Membrane; Single-pass type IV membrane protein (Potential). Integral to membrane (GO:0016021) 14572659 cytoplasm 13 1 cytoplasm cytoplasm Amniota Amniota Metazoa TRAF4 HGNC:12034 TNF receptor-associated factor 4 Q9BUZ4 Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9626059,12354113,11607847,7592751,12354113 cytoplasm 19 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TRAF5 HGNC:12035 TNF receptor-associated factor 5 O00463 Cytoplasm (Probable). Cytoplasm, cytosol. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12000717,8790348,10025951,8790348 nucleus 27 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota TRAF6 HGNC:12036 TNF receptor-associated factor 6, E3 ubiquitin protein ligase Q9Y4K3 Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet (By similarity). Note=Found in the nuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 11960013,,19898473,,,19898473, nucleus 30 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota TRAF7 HGNC:20456 TNF receptor-associated factor 7, E3 ubiquitin protein ligase Q6Q0C0 Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. Cytoplasmic vesicle (GO:0016023) 14743216 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TRAFD1 HGNC:24808 TRAF-type zinc finger domain containing 1 O14545 nucleus 94 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota TRAIP HGNC:30764 TRAF interacting protein Q9BWF2 Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9104814,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota TRAK1 HGNC:29947 trafficking protein, kinesin binding 1 Q9UPV9 Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria. Nucleus (GO:0005634) 12435728 mitochondrion 20 0 cytoplasm. endosome. mitochondrion. nucleus multiple Deuterostomia Bilateria Eumetazoa TRAK2 HGNC:13206 trafficking protein, kinesin binding 2 O60296 Cytoplasm (By similarity). Early endosome (By similarity). Mitochondrion (By similarity). Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 12034717,12034717,16895905 mitochondrion 19 0 cytoplasm cytoplasm Deuterostomia Bilateria Eumetazoa TRAM1 HGNC:20568 translocation associated membrane protein 1 Q15629 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 1315422,15561729 endoplasmic reticulum membrane 100 8 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Bilateria Opisthokonta TRAM1L1 HGNC:28371 translocation associated membrane protein 1-like 1 Q8N609 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 67 8 endoplasmic reticulum membrane endoplasmic reticulum membrane Euarchontoglires Euarchontoglires Opisthokonta TRAM2 HGNC:16855 translocation associated membrane protein 2 Q15035 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 10594243 endoplasmic reticulum membrane 41 8 endoplasmic reticulum endoplasmic reticulum Euteleostomi Euteleostomi Opisthokonta TRANK1 HGNC:29011 tetratricopeptide repeat and ankyrin repeat containing 1 O15050 cytoplasm 54 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms TRAP1 HGNC:16264 TNF receptor-associated protein 1 Q12931 Mitochondrion. Mitochondrion (GO:0005739) 10652318,15561729 cytoplasm 32 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms TRAPPC1 HGNC:19894 trafficking protein particle complex 1 Q9Y5R8 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (GO:0005794) 10582700 mitochondrion 13 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota TRAPPC10 HGNC:11868 trafficking protein particle complex 10 P48553 Golgi apparatus, cis-Golgi network (By similarity). Integral to membrane (GO:0016021) 9196060 nucleus 38 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota TRAPPC11 HGNC:25751 trafficking protein particle complex 11 Q7Z392 Golgi apparatus, cis-Golgi network (By similarity). nucleus 36 0 nucleus nucleus Bilateria Eukaryota Eukaryota TRAPPC12 HGNC:24284 trafficking protein particle complex 12 Q8WVT3 Endoplasmic reticulum-Golgi intermediate compartment. cytoplasm 14 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TRAPPC13 HGNC:25828 trafficking protein particle complex 13 A5PLN9 nucleus 8 0 nucleus nucleus Bilateria Eukaryota Eukaryota TRAPPC2 HGNC:23068 trafficking protein particle complex 2 P0DI81 Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Localized in perinuclear granular structures. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471) 11031107,11031107,11031107 golgi apparatus 26 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota TRAPPC2L HGNC:30887 trafficking protein particle complex 2-like Q9UL33 Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. golgi apparatus 61 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Deuterostomia Eukaryota Eukaryota TRAPPC3 HGNC:19942 trafficking protein particle complex 3 O43617 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (GO:0005794) 10698928 cytoplasm 9 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota TRAPPC3L HGNC:21090 trafficking protein particle complex 3-like Q5T215 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). mitochondrion 6 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota TRAPPC4 HGNC:19943 trafficking protein particle complex 4 Q9Y296 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Cell projection (GO:0042995) 11018053,11018053,11018053,11018053 mitochondrion 11 0 cytoplasm. golgi apparatus multiple Eukaryota Eukaryota NA TRAPPC5 HGNC:23067 trafficking protein particle complex 5 Q8IUR0 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). mitochondrion 26 0 mitochondrion mitochondrion Theria Eukaryota Eukaryota TRAPPC6A HGNC:23069 trafficking protein particle complex 6A O75865 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). mitochondrion 20 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota TRAPPC6B HGNC:23066 trafficking protein particle complex 6B Q86SZ2 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). mitochondrion 22 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota TRAPPC8 HGNC:29169 trafficking protein particle complex 8 Q9Y2L5 Golgi apparatus, cis-Golgi network (By similarity). Golgi apparatus (GO:0005794) 10727015 cytoplasm 21 0 golgi apparatus golgi apparatus Opisthokonta Eukaryota Eukaryota TRAPPC9 HGNC:30832 trafficking protein particle complex 9 Q96Q05 Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). Cytoplasm (By similarity). Note=Processes and cell bodies of neurons (By similarity). golgi apparatus 9 0 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota TRAT1 HGNC:30698 T cell receptor associated transmembrane adaptor 1 Q6PIZ9 Cell membrane; Single-pass type III membrane protein. Plasma membrane (GO:0005886) 9687533 plasma membrane 100 1 plasma membrane plasma membrane Amniota Amniota Tetrapoda TRDMT1 HGNC:2977 tRNA aspartic acid methyltransferase 1 O14717 Nucleus (Probable). Nucleus (GO:0005634) 9592134 nucleus 16 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms TRDN HGNC:12261 triadin Q13061 Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein. Sarcoplasmic reticulum (GO:0016529); Nucleus (GO:0005634) 12659871,11707337,7588753,17081983 endoplasmic reticulum membrane 81 1 endoplasmic reticulum. endoplasmic reticulum membrane. nucleus multiple Amniota Euteleostomi Craniata TREH HGNC:12266 trehalase (brush-border membrane glycoprotein) O43280 Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Plasma membrane (GO:0005886) 9427547 secreted 33 0 secreted secreted Opisthokonta Cell.Organisms Cell.Organisms TREM1 HGNC:17760 triggering receptor expressed on myeloid cells 1 Q9NP99 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential). Plasma membrane (GO:0005886) 12646648 plasma membrane 10 1 plasma membrane plasma membrane Theria Theria Mammalia TREM2 HGNC:17761 triggering receptor expressed on myeloid cells 2 Q9NZC2 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential). Isoform 3: Secreted (Potential). Plasma membrane (GO:0005886) 10799849 plasma membrane 25 1 plasma membrane plasma membrane Amniota Amniota Tetrapoda TREML1 HGNC:20434 triggering receptor expressed on myeloid cells-like 1 Q86YW5 Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. Plasma membrane (GO:0005886) 15128762,12393607 plasma membrane 13 1 cytoplasm. plasma membrane multiple Mammalia Mammalia Euteleostomi TREML2 HGNC:21092 triggering receptor expressed on myeloid cells-like 2 Q5T2D2 Cell membrane; Single-pass type I membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 16 1 plasma membrane plasma membrane Eutheria Mammalia Euteleostomi TREML4 HGNC:30807 triggering receptor expressed on myeloid cells-like 4 Q6UXN2 Secreted (Potential). Integral to membrane (GO:0016021) plasma membrane 12 1 plasma membrane plasma membrane Homininae Euarchontoglires Craniata TRERF1 HGNC:18273 transcriptional regulating factor 1 Q96PN7 Nucleus. Nucleus (GO:0005634) 11349124 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Holozoa TREX1 HGNC:12269 three prime repair exonuclease 1 Q9NSU2 Nucleus (By similarity). Cytoplasm (By similarity). Note=Retained in the cytoplasm through the C-terminal region (By similarity). Nucleus (GO:0005634) 12791985,11721054,17081983 cytoplasm 28 2 nucleus nucleus Mammalia Mammalia Eumetazoa TREX2 HGNC:12270 three prime repair exonuclease 2 Q9BQ50 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634) 12500544/ cytoplasm 40 0 nucleus nucleus Deuterostomia Bilateria NA TRH HGNC:12298 thyrotropin-releasing hormone P20396 Secreted. Extracellular (GO:0005576) 2126343 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Euteleostomi TRHDE HGNC:30748 thyrotropin-releasing hormone degrading enzyme Q9UKU6 Membrane; Single-pass type II membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 10491199,10491199 plasma membrane 22 1 plasma membrane. secreted multiple Amniota Euteleostomi Cell.Organisms TRHR HGNC:12299 thyrotropin-releasing hormone receptor P34981 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Endosome (GO:0005768); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 15117874,12805411,15117874,15117874,12805411,12805411 plasma membrane 100 7 endoplasmic reticulum. endosome. golgi apparatus. plasma membrane multiple Bilateria Bilateria Eumetazoa TRIAP1 HGNC:26937 TP53 regulated inhibitor of apoptosis 1 O43715 Cytoplasm, perinuclear region. Perinuclear region (GO:0048471); Mitochondrion (GO:0005739) 15735003,15735003 cytoplasm 100 0 cytoplasm. mitochondrion multiple Opisthokonta Eukaryota Eukaryota TRIB1 HGNC:16891 tribbles pseudokinase 1 Q96RU8 Cytoplasm (GO:0005737) 9342215 cytoplasm 53 0 cytoplasm cytoplasm Mammalia Euteleostomi Cell.Organisms TRIB2 HGNC:30809 tribbles pseudokinase 2 Q92519 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=May associate with the cytoskeleton (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms TRIB3 HGNC:16228 tribbles pseudokinase 3 Q96RU7 Nucleus. Nucleus (GO:0005634) 12736262 nucleus 100 0 nucleus nucleus Theria Euteleostomi Cell.Organisms TRIL HGNC:22200 TLR4 interactor with leucine-rich repeats Q7L0X0 Membrane; Single-pass type I membrane protein (Potential). secreted 20 1 secreted secreted NA NA NA TRIM10 HGNC:10072 tripartite motif containing 10 Q9UDY6 Cytoplasm. Nucleus (GO:0005634) 10207104 cytoplasm 100 0 cytoplasm. nucleus multiple Mammalia Mammalia NA TRIM11 HGNC:16281 tripartite motif containing 11 Q96F44 Cytoplasm. Nucleus. Nucleoplasm (GO:0005654); Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16904669,16904669,11331580,11331580,16904669 endoplasmic reticulum membrane 29 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eukaryota TRIM13 HGNC:9976 tripartite motif containing 13 O60858 Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum. Cytoplasm (GO:0005737) 11331580 endoplasmic reticulum membrane 100 1 cytoplasm. endoplasmic reticulum membrane multiple Euteleostomi Eukaryota Eukaryota TRIM14 HGNC:16283 tripartite motif containing 14 Q14142 Cytoplasm (GO:0005737) 11331580 plasma membrane 13 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Chordata TRIM15 HGNC:16284 tripartite motif containing 15 Q9C019 cytoplasm 30 0 cytoplasm cytoplasm Mammalia Mammalia NA TRIM16 HGNC:17241 tripartite motif containing 16 O95361 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9817599,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple NA NA Chordata TRIM16L HGNC:32670 tripartite motif containing 16-like Q309B1 Cytoplasm (By similarity). cytoplasm 97 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Chordata TRIM17 HGNC:13430 tripartite motif containing 17 Q9Y577 endoplasmic reticulum membrane 30 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Euarchontoglires Eutheria Eukaryota TRIM2 HGNC:15974 tripartite motif containing 2 Q9C040 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11331580 cytoplasm 99 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms TRIM21 HGNC:11312 tripartite motif containing 21 P19474 Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body. Plasma membrane (GO:0005886); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8882420,7832745,2450143 cytoplasm 31 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria Eukaryota TRIM22 HGNC:16379 tripartite motif containing 22 Q8IYM9 Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies. Cytoplasm (GO:0005737) 11331580 cytoplasm 44 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota TRIM23 HGNC:660 tripartite motif containing 23 P36406 Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures. Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 9671726,10748148,9671726,10748148,11331580 golgi apparatus 51 0 cytoplasm. golgi apparatus. lysosome multiple Deuterostomia Bilateria Cell.Organisms TRIM24 HGNC:11812 tripartite motif containing 24 O15164 Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/9115274,10318760,10610177,15004009,10610177,15004009 nucleus 43 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota TRIM25 HGNC:12932 tripartite motif containing 25 Q14258 Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8248217,12075357 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota TRIM26 HGNC:12962 tripartite motif containing 26 Q12899 Nucleus (GO:0005634) none,15561729 nucleus 33 0 nucleus nucleus Theria Theria NA TRIM27 HGNC:9975 tripartite motif containing 27 P14373 Nucleus (By similarity). Cytoplasm (By similarity). Nucleus, PML body (By similarity). Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1437549,9247190,10976108,9247190,1437549 plasma membrane 34 0 cytoplasm. nucleus multiple Mammalia Eukaryota NA TRIM28 HGNC:16384 tripartite motif containing 28 Q13263 Nucleus. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) ,9016654,10330177,11013263,,15635413,15598749 nucleus 100 0 mitochondrion. nucleus multiple Eutheria Tetrapoda Eukaryota TRIM29 HGNC:17274 tripartite motif containing 29 Q14134 Cytoplasm. Note=Colocalizes with intermediate filaments. Cytoplasm (GO:0005737) 11331580 cytoplasm 100 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Metazoa TRIM3 HGNC:10064 tripartite motif containing 3 O75382 Cytoplasm (By similarity). Early endosome. Cytoplasm (GO:0005737) 10673389,10391919 cytoplasm 60 0 cytoplasm. endosome multiple Euteleostomi Cell.Organisms Cell.Organisms TRIM31 HGNC:16289 tripartite motif containing 31 Q9BZY9 Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria. Nucleus (GO:0005634) endoplasmic reticulum membrane 26 0 cytoplasm. mitochondrion multiple Euarchontoglires Eutheria NA TRIM32 HGNC:16380 tripartite motif containing 32 Q13049 Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus. Nucleus (GO:0005634) 7778269 cytoplasm 100 0 cytoplasm. nucleus multiple Eutheria Tetrapoda Cell.Organisms TRIM33 HGNC:16290 tripartite motif containing 33 Q9UPN9 Nucleus. Note=In discrete nuclear dots resembling nuclear bodies (By similarity). Nucleus (GO:0005634) ,,19135894, nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eukaryota TRIM34 HGNC:10063 tripartite motif containing 34 Q9BYJ4 cytoplasm 50 0 cytoplasm cytoplasm NA NA Eukaryota TRIM35 HGNC:16285 tripartite motif containing 35 Q9UPQ4 Cytoplasm (By similarity). Nucleus (By similarity). Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14662771,12692137,14662771,12692137 nucleus 21 0 cytoplasm. nucleus multiple Amniota Eukaryota Eukaryota TRIM36 HGNC:16280 tripartite motif containing 36 Q9NQ86 Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Found in the acrosomal region of elongated spermatids and mature sperm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 15145053,15145053 cytoplasm 18 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota TRIM37 HGNC:7523 tripartite motif containing 37 O94972 Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. Peroxisome (GO:0005777); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 11938494,11279055/17081983 cytoplasm 25 0 cytoplasm. nucleus. peroxisome multiple Deuterostomia Eukaryota Eukaryota TRIM38 HGNC:10059 tripartite motif containing 38 O00635 Nucleus (GO:0005634) plasma membrane 26 0 n/a n/a Eutheria Eutheria Eukaryota TRIM39 HGNC:10065 tripartite motif containing 39 Q9HCM9 Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when co-localized with MOAP1. plasma membrane 32 0 cytoplasm. mitochondrion multiple Mammalia Eukaryota NA TRIM4 HGNC:16275 tripartite motif containing 4 Q9C037 Cytoplasm (GO:0005737) 11331580 nucleus 28 0 cytoplasm cytoplasm Catarrhini Eutheria Eukaryota TRIM40 HGNC:18736 tripartite motif containing 40 Q6P9F5 Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Theria Theria NA TRIM41 HGNC:19013 tripartite motif containing 41 Q8WV44 Cytoplasm. Nucleus. cytoplasm 25 0 cytoplasm. nucleus multiple Amniota Amniota Eukaryota TRIM42 HGNC:19014 tripartite motif containing 42 Q8IWZ5 Nucleus (GO:0005634) cytoplasm 20 0 cytoplasm cytoplasm Amniota Amniota Eukaryota TRIM43 HGNC:19015 tripartite motif containing 43 Q96BQ3 nucleus 29 0 nucleus nucleus Eutheria Eutheria Eukaryota TRIM43B HGNC:37146 tripartite motif containing 43B A6NCK2 endoplasmic reticulum membrane 38 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eutheria NA TRIM44 HGNC:19016 tripartite motif containing 44 Q96DX7 Cytoplasm (GO:0005737) 11165382 nucleus 26 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota TRIM45 HGNC:19018 tripartite motif containing 45 Q9H8W5 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15351693,15351693 cytoplasm 28 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Eukaryota TRIM46 HGNC:19019 tripartite motif containing 46 Q7Z4K8 Nucleus (GO:0005634) cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota TRIM47 HGNC:19020 tripartite motif containing 47 Q96LD4 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11511098,17081983 cytoplasm 30 0 cytoplasm. nucleus multiple Mammalia Mammalia Metazoa TRIM48 HGNC:19021 tripartite motif containing 48 Q8IWZ4 Nucleus (GO:0005634) endoplasmic reticulum membrane 28 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Eutheria Eukaryota TRIM49 HGNC:13431 tripartite motif containing 49 P0CI25 nucleus 26 0 nucleus nucleus Eutheria Eutheria Eukaryota TRIM49B HGNC:42955 tripartite motif containing 49B A6NDI0 endoplasmic reticulum membrane 28 0 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eukaryota TRIM49C HGNC:38877 tripartite motif containing 49C P0CI26 nucleus 26 0 nucleus nucleus Human Human Eukaryota TRIM49D1 HGNC:43973 tripartite motif containing 49D1 C9J1S8 nucleus 29 0 nucleus nucleus NA NA NA TRIM5 HGNC:16276 tripartite motif containing 5 Q9C035 Cytoplasm, P-body. Note=Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Co-localizes with SQSTM1 in cytoplasmic bodies. Cytoplasm (GO:0005737) 11331580 cytoplasm 100 0 cytoplasm cytoplasm Euarchontoglires Eutheria Eukaryota TRIM50 HGNC:19017 tripartite motif containing 50 Q86XT4 Cytoplasm. Nucleus (GO:0005634) cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eukaryota NA TRIM51 HGNC:19023 tripartite motif-containing 51 Q9BSJ1 Nucleus (GO:0005634) endoplasmic reticulum membrane 24 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Catarrhini Eukaryota TRIM52 HGNC:19024 tripartite motif containing 52 Q96A61 Nucleus (GO:0005634) cytoplasm 41 0 cytoplasm cytoplasm Catarrhini Eutheria Eukaryota TRIM54 HGNC:16008 tripartite motif containing 54 Q9BYV2 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 10953002/11243782,10953002 cytoplasm 94 0 cytoplasm cytoplasm Mammalia Eukaryota Eukaryota TRIM55 HGNC:14215 tripartite motif containing 55 Q9BYV6 Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12414993,12414993 cytoplasm 54 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota TRIM56 HGNC:19028 tripartite motif containing 56 Q9BRZ2 Cytoplasm (By similarity). Nucleus (GO:0005634) 17081983 cytoplasm 79 0 nucleus nucleus Eutheria Eutheria Eukaryota TRIM58 HGNC:24150 tripartite motif containing 58 Q8NG06 nucleus 29 0 nucleus nucleus Mammalia Tetrapoda Eukaryota TRIM59 HGNC:30834 tripartite motif containing 59 Q8IWR1 Membrane; Single-pass membrane protein (Potential). cytoplasm 30 2 cytoplasm cytoplasm Amniota Deuterostomia Eukaryota TRIM6 HGNC:16277 tripartite motif containing 6 Q9C030 Nucleus (GO:0005634) 11331580 cytoplasm 48 0 nucleus nucleus Eutheria Bilateria Eukaryota TRIM60 HGNC:21162 tripartite motif containing 60 Q495X7 endoplasmic reticulum membrane 35 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Euarchontoglires Eukaryota TRIM61 HGNC:24339 tripartite motif containing 61 Q5EBN2 Nucleus (GO:0005634) endoplasmic reticulum membrane 29 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Catarrhini Eukaryota TRIM62 HGNC:25574 tripartite motif containing 62 Q9BVG3 Nucleus (GO:0005634) cytoplasm 30 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota TRIM63 HGNC:16007 tripartite motif containing 63, E3 ubiquitin protein ligase Q969Q1 Cytoplasm. Nucleus (By similarity). Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11283016,11243782 cytoplasm 49 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota TRIM64 HGNC:14663 tripartite motif containing 64 A6NGJ6 nucleus 26 0 nucleus nucleus Catarrhini Eutheria NA TRIM64B HGNC:37147 tripartite motif containing 64B A6NI03 nucleus 26 0 nucleus nucleus Catarrhini Eutheria Eukaryota TRIM64C HGNC:37148 tripartite motif containing 64C A6NLI5 nucleus 27 0 nucleus nucleus Catarrhini Eutheria Eukaryota TRIM65 HGNC:27316 tripartite motif containing 65 Q6PJ69 endoplasmic reticulum membrane 30 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Eukaryota TRIM66 HGNC:29005 tripartite motif containing 66 O15016 Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm (By similarity). nucleus 100 0 nucleus nucleus Theria Euteleostomi Cell.Organisms TRIM67 HGNC:31859 tripartite motif containing 67 Q6ZTA4 Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Microtubule-associated (By similarity). cytoplasm 11 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota TRIM68 HGNC:21161 tripartite motif containing 68 Q6AZZ1 Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11560955,11560955 plasma membrane 28 0 cytoplasm. nucleus multiple Eutheria Eutheria Eukaryota TRIM69 HGNC:17857 tripartite motif containing 69 Q86WT6 Cytoplasm. Nucleus. Nucleus speckle. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12837286,12837286 nucleus 31 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eukaryota TRIM7 HGNC:16278 tripartite motif containing 7 Q9C029 Cytoplasm (GO:0005737) 11916970 secreted 28 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota TRIM71 HGNC:32669 tripartite motif containing 71, E3 ubiquitin protein ligase Q2Q1W2 Cytoplasm, P-body (By similarity). cytoplasm 89 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms TRIM72 HGNC:32671 tripartite motif containing 72, E3 ubiquitin protein ligase Q6ZMU5 Cell membrane, sarcolemma (By similarity). Cytoplasmic vesicle membrane (By similarity). Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine (By similarity). cytoplasm 22 0 cytoplasm cytoplasm Mammalia Tetrapoda Eukaryota TRIM73 HGNC:18162 tripartite motif containing 73 Q86UV7 Nucleus (GO:0005634) cytoplasm 92 0 cytoplasm cytoplasm Eutheria Eukaryota NA TRIM74 HGNC:17453 tripartite motif containing 74 Q86UV6 Nucleus (GO:0005634) cytoplasm 92 0 cytoplasm cytoplasm Eutheria Eukaryota NA TRIM77 HGNC:34228 tripartite motif containing 77 I1YAP6 endoplasmic reticulum membrane 35 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Homininae Eutheria NA TRIM8 HGNC:15579 tripartite motif containing 8 Q9BZR9 Nucleus (GO:0005634) 11331580 endoplasmic reticulum membrane 30 0 nucleus nucleus Amniota Euteleostomi Eukaryota TRIM9 HGNC:16288 tripartite motif containing 9 Q9C026 Cytoplasm. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle- associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum. Cytoplasm (GO:0005737) 11331580 secreted 15 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota TRIML1 HGNC:26698 tripartite motif family-like 1 Q8N9V2 endoplasmic reticulum membrane 33 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Mammalia Eukaryota TRIML2 HGNC:26378 tripartite motif family-like 2 Q8N7C3 plasma membrane 14 0 n/a n/a Eutheria Eutheria Metazoa TRIO HGNC:12303 trio Rho guanine nucleotide exchange factor O75962 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 14720465,17081983 cytoplasm 95 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms TRIOBP HGNC:17009 TRIO and F-actin binding protein Q9H2D6 Nucleus. Cytoplasm, cytoskeleton. Isoform 1: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. cytoplasm 32 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms TRIP10 HGNC:12304 thyroid hormone receptor interactor 10 Q15642 Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Isoform 5: Cytoplasm, perinuclear region. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12604778,17081983,12604778,10713100,12456510,17081983,12242347 cytoplasm 3 0 cytoplasm. golgi apparatus. lysosome. nucleus multiple Mammalia Euteleostomi Eukaryota TRIP11 HGNC:12305 thyroid hormone receptor interactor 11 Q15643 Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules. Centrosome (GO:0005813); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10189370,11463340,17081983,17081983 cytoplasm 16 0 cytoplasm. golgi apparatus. nucleus multiple Tetrapoda Bilateria Eukaryota TRIP12 HGNC:12306 thyroid hormone receptor interactor 12 Q14669 Nucleus, nucleoplasm. Nucleus (GO:0005634) nucleus 100 2 nucleus nucleus Eukaryota Eukaryota Eukaryota TRIP13 HGNC:12307 thyroid hormone receptor interactor 13 Q15645 Nucleus (GO:0005634) 7776974,9199503 nucleus 20 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms TRIP4 HGNC:12310 thyroid hormone receptor interactor 4 Q15650 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic under conditions of serum deprivation. Co-localizes with NEK6 in the centrosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10454579,10454579 cytoplasm 44 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms TRIP6 HGNC:12311 thyroid hormone receptor interactor 6 Q15654 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11336797,16137684,14688263,11336797,17081983,14688263,16137684 cytoplasm 22 0 cytoplasm. nucleus multiple Mammalia Euteleostomi Eukaryota TRIQK HGNC:27828 triple QxxK/R motif containing Q629K1 Endoplasmic reticulum membrane; Single-pass membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Catarrhini Amniota Euteleostomi TRIT1 HGNC:20286 tRNA isopentenyltransferase 1 Q9H3H1 Isoform 1: Mitochondrion (Potential). Isoform 4: Mitochondrion (Potential). Isoform 2: Cytoplasm (Potential). Isoform 3: Cytoplasm (Potential). Isoform 5: Cytoplasm (Potential). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 11560893,17081983,11560893,11560893 mitochondrion 31 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms TRMT1 HGNC:25980 tRNA methyltransferase 1 homolog (S. cerevisiae) Q9NXH9 mitochondrion 31 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms TRMT10A HGNC:28403 tRNA methyltransferase 10 homolog A (S. cerevisiae) Q8TBZ6 mitochondrion 8 0 mitochondrion mitochondrion Eukaryota Eukaryota Eukaryota TRMT10B HGNC:26454 tRNA methyltransferase 10 homolog B (S. cerevisiae) Q6PF06 mitochondrion 15 0 mitochondrion mitochondrion Deuterostomia Deuterostomia Eukaryota TRMT10C HGNC:26022 tRNA methyltransferase 10 homolog C (S. cerevisiae) Q7L0Y3 Mitochondrion matrix, mitochondrion nucleoid. Nucleus (GO:0005634) 15561729 mitochondrion 100 0 mitochondrion. nucleus multiple Bilateria Bilateria Eukaryota TRMT11 HGNC:21080 tRNA methyltransferase 11 homolog (S. cerevisiae) Q7Z4G4 cytoplasm 21 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TRMT112 HGNC:26940 tRNA methyltransferase 11-2 homolog (S. cerevisiae) Q9UI30 cytoplasm 19 0 cytoplasm cytoplasm Eutheria Eukaryota Eukaryota TRMT12 HGNC:26091 tRNA methyltransferase 12 homolog (S. cerevisiae) Q53H54 cytoplasm 24 0 cytoplasm cytoplasm Opisthokonta Cell.Organisms Cell.Organisms TRMT13 HGNC:25502 tRNA methyltransferase 13 homolog (S. cerevisiae) Q9NUP7 nucleus 30 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TRMT1L HGNC:16782 tRNA methyltransferase 1 homolog (S. cerevisiae)-like Q7Z2T5 Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 cytoplasm 30 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms TRMT2A HGNC:24974 tRNA methyltransferase 2 homolog A (S. cerevisiae) Q8IZ69 nucleus 25 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms TRMT2B HGNC:25748 tRNA methyltransferase 2 homolog B (S. cerevisiae) Q96GJ1 mitochondrion 18 0 mitochondrion mitochondrion Tetrapoda Euteleostomi Cell.Organisms TRMT44 HGNC:26653 tRNA methyltransferase 44 homolog (S. cerevisiae) Q8IYL2 Cytoplasm (Probable). cytoplasm 27 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota TRMT5 HGNC:23141 tRNA methyltransferase 5 Q32P41 Mitochondrion matrix (By similarity). Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly in the mitochondria and in the nucleus (By similarity). mitochondrion 39 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms TRMT6 HGNC:20900 tRNA methyltransferase 6 homolog (S. cerevisiae) Q9UJA5 Nucleus (By similarity). nucleus 15 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TRMT61A HGNC:23790 tRNA methyltransferase 61 homolog A (S. cerevisiae) Q96FX7 Nucleus (By similarity). nucleus 31 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms TRMT61B HGNC:26070 tRNA methyltransferase 61 homolog B (S. cerevisiae) Q9BVS5 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Eutheria Cell.Organisms Cell.Organisms TRMU HGNC:25481 tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase O75648 Mitochondrion. Mitochondrion (GO:0005739) 15509579,15944150 mitochondrion 100 0 mitochondrion mitochondrion Euteleostomi Cell.Organisms Cell.Organisms TRNAU1AP HGNC:30813 tRNA selenocysteine 1 associated protein 1 Q9NX07 Nucleus (By similarity). Cytoplasm (By similarity). Note=Abundant in the nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10606267,10606267 nucleus 25 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms TRNP1 HGNC:34348 TMF1-regulated nuclear protein 1 Q6NT89 Nucleus (By similarity). nucleus 76 1 nucleus nucleus NA NA Mammalia TRNT1 HGNC:17341 tRNA nucleotidyl transferase, CCA-adding, 1 Q96Q11 Mitochondrion. Mitochondrion (GO:0005739) 12729736,11504732 mitochondrion 100 0 mitochondrion mitochondrion Bilateria Cell.Organisms Cell.Organisms TRO HGNC:12326 trophinin Q12816 Plasma membrane (GO:0005886) 7758945,9560222 nucleus 22 0 nucleus nucleus Euarchontoglires Deuterostomia Cell.Organisms TROAP HGNC:12327 trophinin associated protein Q12815 Cytoplasm. Cytoplasm (GO:0005737) 7758945 cytoplasm 100 0 cytoplasm cytoplasm Eutheria Mammalia Mammalia TROVE2 HGNC:11313 TROVE domain family, member 2 P10155 Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Nucleolus (GO:0005730); Plasma membrane (GO:0005886) 6201849,1999763,7602431,6421292,12102760,7602431,12102760 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms TRPA1 HGNC:497 transient receptor potential cation channel, subfamily A, member 1 O75762 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 10066796 mitochondrion 15 6 plasma membrane plasma membrane Bilateria Bilateria Cell.Organisms TRPC1 HGNC:12333 transient receptor potential cation channel, subfamily C, member 1 P48995 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7568191,12732636 plasma membrane 35 8 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota TRPC3 HGNC:12335 transient receptor potential cation channel, subfamily C, member 3 Q13507 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12730194,15744307,15327778 plasma membrane 30 9 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms TRPC4 HGNC:12336 transient receptor potential cation channel, subfamily C, member 4 Q9UBN4 Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor. Nucleus (GO:0005634);Plasma membrane (GO:0005886) 17081983/11042129 plasma membrane 65 8 nucleus. plasma membrane multiple Bilateria Eukaryota Eukaryota TRPC4AP HGNC:16181 transient receptor potential cation channel, subfamily C, member 4 associated protein Q8TEL6 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 14585990,11133832 nucleus 62 1 cytoplasm. endoplasmic reticulum multiple Euteleostomi Eukaryota Eukaryota TRPC5 HGNC:12337 transient receptor potential cation channel, subfamily C, member 5 Q9UL62 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12531519 plasma membrane 100 8 plasma membrane plasma membrane Bilateria Eukaryota Opisthokonta TRPC6 HGNC:12338 transient receptor potential cation channel, subfamily C, member 6 Q9Y210 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 12351388,14688372,14699131 plasma membrane 30 9 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms TRPC7 HGNC:20754 transient receptor potential cation channel, subfamily C, member 7 Q9HCX4 Cell membrane; Multi-pass membrane protein. Nucleus envelope. Plasma membrane (GO:0005886) 11805119 plasma membrane 32 9 plasma membrane plasma membrane Deuterostomia Bilateria Holozoa TRPM1 HGNC:7146 transient receptor potential cation channel, subfamily M, member 1 Q7Z4N2 Cell membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11535825,11535825,17081983 plasma membrane 11 9 cytoplasm. plasma membrane multiple Bilateria Eukaryota Holozoa TRPM2 HGNC:12339 transient receptor potential cation channel, subfamily M, member 2 O94759 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886);Plasma membrane (GO:0005886) 11385575/12594222 mitochondrion 25 9 plasma membrane plasma membrane Euteleostomi Deuterostomia Cell.Organisms TRPM3 HGNC:17992 transient receptor potential cation channel, subfamily M, member 3 Q9HCF6 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12672799,12672827,12672827 plasma membrane 9 11 cytoplasm. plasma membrane multiple Bilateria Eukaryota Cell.Organisms TRPM4 HGNC:17993 transient receptor potential cation channel, subfamily M, member 4 Q8TD43 Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Isoform 2: Endoplasmic reticulum. Golgi apparatus. Plasma membrane (GO:0005886) 12015988 plasma membrane 6 7 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Euteleostomi Deuterostomia Holozoa TRPM5 HGNC:14323 transient receptor potential cation channel, subfamily M, member 5 Q9NZQ8 Cell membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14634208,17081983 plasma membrane 9 9 cytoplasm. plasma membrane multiple Euteleostomi Deuterostomia Opisthokonta TRPM6 HGNC:17995 transient receptor potential cation channel, subfamily M, member 6 Q9BX84 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12032568 nucleus 15 8 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota TRPM7 HGNC:17994 transient receptor potential cation channel, subfamily M, member 7 Q96QT4 Membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11161216,11161216 nucleus 10 7 cytoplasm. plasma membrane multiple Bilateria Eukaryota Eukaryota TRPM8 HGNC:17961 transient receptor potential cation channel, subfamily M, member 8 Q7Z2W7 Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. Plasma membrane (GO:0005886) plasma membrane 12 9 plasma membrane plasma membrane Euteleostomi Deuterostomia Eukaryota TRPS1 HGNC:12340 trichorhinophalangeal syndrome I Q9UHF7 Nucleus. Nucleus (GO:0005634) 11359471 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota TRPT1 HGNC:20316 tRNA phosphotransferase 1 Q86TN4 nucleus 51 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms TRPV1 HGNC:12716 transient receptor potential cation channel, subfamily V, member 1 Q8NER1 Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886); Synaptic vesicle (GO:0008021) 11124944,12454015,15066994,15066994 plasma membrane 18 6 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms TRPV2 HGNC:18082 transient receptor potential cation channel, subfamily V, member 2 Q9Y5S1 Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Plasma membrane (GO:0005886) 12765693,14991772 cytoplasm 17 6 melanosome. plasma membrane multiple Euteleostomi Euteleostomi Cell.Organisms TRPV3 HGNC:18084 transient receptor potential cation channel, subfamily V, member 3 Q8NET8 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12016205 plasma membrane 17 6 plasma membrane plasma membrane Tetrapoda Tetrapoda Cell.Organisms TRPV4 HGNC:18083 transient receptor potential cation channel, subfamily V, member 4 Q9HBA0 Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, adherens junction (By similarity). Isoform 1: Cell membrane. Isoform 5: Cell membrane. Plasma membrane (GO:0005886); Vesicle (None); Endoplasmic reticulum (GO:0005783) 11160995,17110928,17110928,,17932042, plasma membrane 23 6 endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota TRPV5 HGNC:3145 transient receptor potential cation channel, subfamily V, member 5 Q9NQA5 Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. Plasma membrane (GO:0005886) 10945469,11549322 plasma membrane 100 6 plasma membrane plasma membrane Bilateria Bilateria NA TRPV6 HGNC:14006 transient receptor potential cation channel, subfamily V, member 6 Q9H1D0 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739); Nucleus (GO:0005634) 12660155,12765696,15192090,17081983 plasma membrane 88 6 endoplasmic reticulum. mitochondrion. nucleus. plasma membrane multiple Bilateria Bilateria NA TRRAP HGNC:12347 transformation/transcription domain-associated protein Q9Y4A5 Nucleus. Nucleus (GO:0005634); Mitochondrion (GO:0005739); Extracellular (GO:0005576) 9708738,11839798,9885574,16260778,15598749,15561729 nucleus 100 4 mitochondrion. nucleus. secreted multiple Opisthokonta Eukaryota NA TRUB1 HGNC:16060 TruB pseudouridine (psi) synthase family member 1 Q8WWH5 nucleus 14 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms TRUB2 HGNC:17170 TruB pseudouridine (psi) synthase family member 2 O95900 cytoplasm 23 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms TSACC HGNC:30636 TSSK6 activating co-chaperone Q96A04 nucleus 36 0 nucleus nucleus Theria Theria Mammalia TSC1 HGNC:12362 tuberous sclerosis 1 Q92574 Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes. Cytoplasm (GO:0005737); Centrosome (GO:0005813) ,12226091,9580671,10585443,17658474,,16339216 secreted 15 1 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota TSC2 HGNC:12363 tuberous sclerosis 2 P49815 Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes. Nucleus (GO:0005634);Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Perinuclear region (GO:0048471) 17081983/10807585,16636147,10585443,14559897,16636147,17081983,8806680,11703097,14559897 cytoplasm 20 6 cytoplasm. golgi apparatus. nucleus. plasma membrane multiple Opisthokonta Eukaryota Eukaryota TSC22D1 HGNC:16826 TSC22 domain family, member 1 Q15714 Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11095965,11095965 cytoplasm 15 0 cytoplasm. nucleus multiple Amniota Euteleostomi Bilateria TSC22D2 HGNC:29095 TSC22 domain family, member 2 O75157 nucleus 19 0 nucleus nucleus Bilateria Bilateria Bilateria TSC22D3 HGNC:3051 TSC22 domain family, member 3 Q99576 Nucleus (GO:0005634) 12671681 nucleus 32 0 nucleus nucleus Chordata Bilateria Bilateria TSC22D4 HGNC:21696 TSC22 domain family, member 4 Q9Y3Q8 Nucleus (Potential). nucleus 20 0 nucleus nucleus Theria Bilateria Bilateria TSEN15 HGNC:16791 TSEN15 tRNA splicing endonuclease subunit Q8WW01 Nucleus (Probable). Nucleus, nucleolus (Probable). Note=May be transiently localized in the nucleolus (Probable). secreted 21 0 nucleus nucleus Tetrapoda Bilateria Holozoa TSEN2 HGNC:28422 TSEN2 tRNA splicing endonuclease subunit Q8NCE0 Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 15109492,15109492 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms TSEN34 HGNC:15506 TSEN34 tRNA splicing endonuclease subunit Q9BSV6 Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus. nucleus 100 0 nucleus nucleus Opisthokonta Cell.Organisms NA TSEN54 HGNC:27561 TSEN54 tRNA splicing endonuclease subunit Q7Z6J9 Nucleus (Probable). Nucleus, nucleolus (Probable). Note=May be transiently localized in the nucleolus (Probable). Nucleus (GO:0005634) nucleus 59 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota TSFM HGNC:12367 Ts translation elongation factor, mitochondrial P43897 Mitochondrion. Mitochondrion (GO:0005739) 7615523,15598749 mitochondrion 100 0 mitochondrion mitochondrion Theria Cell.Organisms Cell.Organisms TSG101 HGNC:15971 tumor susceptibility 101 Q99816 Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794) 12205095,12101421,12205095,12101421,12101421 cytoplasm 17 0 cytoplasm. golgi apparatus. nucleus multiple Bilateria Eukaryota Eukaryota TSGA10 HGNC:14927 testis specific, 10 Q9BZW7 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus membrane (By similarity). Note=The 27 kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail while the 55 kDa peptide localizes to the midpiece (By similarity). Axoneme (GO:0005930) 16777103 cytoplasm 24 0 cytoplasm cytoplasm Theria Amniota Cell.Organisms TSGA10IP HGNC:26555 testis specific, 10 interacting protein Q3SY00 nucleus 54 0 nucleus nucleus Eutheria Mammalia NA TSGA13 HGNC:12369 testis specific, 13 Q96PP4 nucleus 68 0 nucleus nucleus Theria Theria NA TSHB HGNC:12372 thyroid stimulating hormone, beta P01222 Secreted. Extracellular (GO:0005576) 3839756 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Bilateria TSHR HGNC:12373 thyroid stimulating hormone receptor P16473 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 8496155,12383251,12383251,14604818 plasma membrane 100 7 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Bilateria Bilateria Holozoa TSHZ1 HGNC:10669 teashirt zinc finger homeobox 1 Q6ZSZ6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 79 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria TSHZ2 HGNC:13010 teashirt zinc finger homeobox 2 Q9NRE2 Nucleus (Probable). nucleus 42 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria TSHZ3 HGNC:30700 teashirt zinc finger homeobox 3 Q63HK5 Nucleus. Cell projection, growth cone (By similarity). Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria TSKS HGNC:30719 testis-specific serine kinase substrate Q9UJT2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis. cytoplasm 100 0 cytoplasm cytoplasm Theria Theria Amniota TSKU HGNC:28850 tsukushi, small leucine rich proteoglycan Q8WUA8 Secreted (Potential). plasma membrane 18 0 n/a n/a Euteleostomi Eukaryota Cell.Organisms TSLP HGNC:30743 thymic stromal lymphopoietin Q969D9 Secreted. Extracellular (GO:0005576) 11418668 secreted 100 0 secreted secreted Euarchontoglires Euarchontoglires Eutheria TSN HGNC:12379 translin Q15631 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9111049,15138261,9111049,15138261 cytoplasm 30 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota TSNARE1 HGNC:26437 t-SNARE domain containing 1 Q96NA8 Membrane; Single-pass membrane protein (By similarity). nucleus 28 1 nucleus nucleus Tetrapoda Bilateria Eukaryota TSNAX HGNC:12380 translin-associated factor X Q99598 Cytoplasm, perinuclear region. Golgi apparatus (By similarity). Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12036294,11278549,14642810 nucleus 57 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota TSNAXIP1 HGNC:18586 translin-associated factor X interacting protein 1 Q2TAA8 Cytoplasm, perinuclear region (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12036294,12036294 cytoplasm 72 0 cytoplasm. nucleus multiple Deuterostomia Deuterostomia Metazoa TSPAN1 HGNC:20657 tetraspanin 1 O60635 Lysosome membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Lysosome (GO:0005764); Endoplasmic reticulum (GO:0005783); Cell surface (GO:0009986) 19508227,19508227,19508227,18851943 golgi apparatus membrane 67 4 endoplasmic reticulum. lysosome. lysosome membrane. plasma membrane multiple Euteleostomi Euteleostomi Metazoa TSPAN10 HGNC:29942 tetraspanin 10 Q9H1Z9 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 49 4 golgi apparatus membrane golgi apparatus membrane Theria Euteleostomi Metazoa TSPAN11 HGNC:30795 tetraspanin 11 A1L157 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 67 4 golgi apparatus membrane golgi apparatus membrane Mammalia Bilateria Holozoa TSPAN12 HGNC:21641 tetraspanin 12 O95859 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) 10719184 golgi apparatus membrane 51 4 golgi apparatus membrane golgi apparatus membrane Chordata Chordata Holozoa TSPAN13 HGNC:21643 tetraspanin 13 O95857 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) 10719184 golgi apparatus membrane 66 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Holozoa TSPAN14 HGNC:23303 tetraspanin 14 Q8NG11 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) golgi apparatus membrane 65 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Metazoa TSPAN15 HGNC:23298 tetraspanin 15 O95858 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) 10719184 golgi apparatus membrane 69 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Holozoa TSPAN16 HGNC:30725 tetraspanin 16 Q9UKR8 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) golgi apparatus membrane 53 3 golgi apparatus membrane golgi apparatus membrane Catarrhini Eutheria Metazoa TSPAN17 HGNC:13594 tetraspanin 17 Q96FV3 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 69 4 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Opisthokonta TSPAN18 HGNC:20660 tetraspanin 18 Q96SJ8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 69 4 golgi apparatus membrane golgi apparatus membrane Deuterostomia Deuterostomia Eumetazoa TSPAN19 HGNC:31886 tetraspanin 19 P0C672 Membrane; Multi-pass membrane protein (Probable). golgi apparatus membrane 60 4 golgi apparatus membrane golgi apparatus membrane NA NA Holozoa TSPAN2 HGNC:20659 tetraspanin 2 O60636 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) golgi apparatus membrane 52 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Opisthokonta TSPAN3 HGNC:17752 tetraspanin 3 O60637 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) 9714763 golgi apparatus membrane 69 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Deuterostomia Holozoa TSPAN31 HGNC:10539 tetraspanin 31 Q12999 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 7789984 golgi apparatus membrane 66 4 plasma membrane plasma membrane Euarchontoglires Bilateria Holozoa TSPAN32 HGNC:13410 tetraspanin 32 Q96QS1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 41 4 golgi apparatus membrane golgi apparatus membrane Amniota Amniota Craniata TSPAN33 HGNC:28743 tetraspanin 33 Q86UF1 Membrane; Multi-pass membrane protein (Potential). Cell surface (GO:0009986); Cytoplasmic vesicle membrane (GO:0030659) 17158226,17158226 golgi apparatus membrane 60 4 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Opisthokonta TSPAN4 HGNC:11859 tetraspanin 4 O14817 Membrane; Multi-pass membrane protein. Cell surface (GO:0009986) 9360996 golgi apparatus membrane 48 4 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Holozoa TSPAN5 HGNC:17753 tetraspanin 5 P62079 Membrane; Multi-pass membrane protein (Probable). Integral to membrane (GO:0016021) 10719184 golgi apparatus membrane 73 4 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Opisthokonta TSPAN6 HGNC:11858 tetraspanin 6 O43657 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 9714763 golgi apparatus membrane 65 4 plasma membrane plasma membrane Euarchontoglires Euteleostomi Eukaryota TSPAN7 HGNC:11854 tetraspanin 7 P41732 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11739647 golgi apparatus membrane 64 4 plasma membrane plasma membrane Chordata Bilateria Eukaryota TSPAN8 HGNC:11855 tetraspanin 8 P19075 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 12939584 golgi apparatus membrane 63 4 plasma membrane plasma membrane Tetrapoda Euteleostomi Holozoa TSPAN9 HGNC:21640 tetraspanin 9 O75954 Membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface (By similarity). Plasma membrane (GO:0005886) 10719184 golgi apparatus membrane 64 4 plasma membrane plasma membrane Deuterostomia Bilateria Holozoa TSPEAR HGNC:1268 thrombospondin-type laminin G domain and EAR repeats Q8WU66 Secreted (By similarity). Cell surface (By similarity). Cell projection, stereocilium (By similarity). Note=Secreted protein which may bind to the cell surface via a membrane receptor (By similarity). Extracellular (GO:0005576) secreted 18 0 secreted secreted Chordata Chordata NA TSPO HGNC:1158 translocator protein (18kDa) B1AH88 Mitochondrion (GO:0005739) 1847678 secreted 87 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms TSPO2 HGNC:21256 translocator protein 2 Q5TGU0 Endoplasmic reticulum membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 100 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Eumetazoa TSPY1 HGNC:12381 testis specific protein, Y-linked 1 Q01534 Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8923009,8923009 nucleus 35 0 cytoplasm. nucleus multiple NA NA Eukaryota TSPY10 HGNC:37473 testis specific protein, Y-linked 10 P0CW01 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 35 0 nucleus nucleus NA NA Eukaryota TSPY2 HGNC:23924 testis specific protein, Y-linked 2 A6NKD2 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 34 0 nucleus nucleus Homininae Eutheria Eukaryota TSPY3 HGNC:33876 testis specific protein, Y-linked 3 P0CV98 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 35 0 nucleus nucleus NA NA Eukaryota TSPY4 HGNC:37287 testis specific protein, Y-linked 4 P0CV99 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 35 0 nucleus nucleus NA NA Eukaryota TSPY8 HGNC:37471 testis specific protein, Y-linked 8 P0CW00 Cytoplasm (By similarity). Nucleus (By similarity). nucleus 35 0 nucleus nucleus NA NA Eukaryota TSPYL1 HGNC:12382 TSPY-like 1 Q9H0U9 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634) 12429849,15635413,15273283 nucleus 100 0 nucleus nucleus Eutheria Eutheria Eukaryota TSPYL2 HGNC:24358 TSPY-like 2 Q9H2G4 Nucleus. Cytoplasm (By similarity). Note=Enriched in transcriptionally active regions of chromatin in neurons (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 11395479,17081983,11395479,11318608,11395479,11318608 nucleus 46 0 cytoplasm. nucleus multiple Eutheria Eutheria NA TSPYL4 HGNC:21559 TSPY-like 4 Q9UJ04 nucleus 46 0 nucleus nucleus Eutheria Eutheria Eukaryota TSPYL5 HGNC:29367 TSPY-like 5 Q86VY4 nucleus 31 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota TSPYL6 HGNC:14521 TSPY-like 6 Q8N831 Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Catarrhini Catarrhini Eukaryota TSR1 HGNC:25542 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) Q2NL82 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 17000644,17081983 nucleus 30 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TSR2 HGNC:25455 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) Q969E8 nucleus 61 0 nucleus nucleus Mammalia Eukaryota Eukaryota TSR3 HGNC:14175 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) Q9UJK0 nucleus 79 1 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms TSSC1 HGNC:12383 tumor suppressing subtransferable candidate 1 Q53HC9 nucleus 19 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms TSSC4 HGNC:12386 tumor suppressing subtransferable candidate 4 Q9Y5U2 Cytoplasm (GO:0005737) 17081983 nucleus 92 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Bilateria TSSK1B HGNC:14968 testis-specific serine kinase 1B Q9BXA7 Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Cell projection, cilium, flagellum (By similarity). Note=In spermatozoa, present in the sperm head and in the flagellum (By similarity). Cytoplasm (GO:0005737) 9412477 cytoplasm 28 1 cytoplasm cytoplasm Theria Chordata Cell.Organisms TSSK2 HGNC:11401 testis-specific serine kinase 2 Q96PF2 Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. Cytoplasm (GO:0005737) 9412477 nucleus 22 1 cytoplasm cytoplasm Mammalia Bilateria Cell.Organisms TSSK3 HGNC:15473 testis-specific serine kinase 3 Q96PN8 cytoplasm 27 1 cytoplasm cytoplasm Theria Bilateria Cell.Organisms TSSK4 HGNC:19825 testis-specific serine kinase 4 Q6SA08 cytoplasm 22 1 cytoplasm cytoplasm Theria Bilateria Cell.Organisms TSSK6 HGNC:30410 testis-specific serine kinase 6 Q9BXA6 Acrosome (GO:0001669); Perinuclear region (GO:0048471) 15870294,15870294 cytoplasm 25 1 cytoplasm. lysosome multiple Amniota Deuterostomia Cell.Organisms TST HGNC:12388 thiosulfate sulfurtransferase (rhodanese) Q16762 Mitochondrion matrix. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 11112515,1451437 mitochondrion 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms TSTA3 HGNC:12390 tissue specific transplantation antigen P35B Q13630 Cytoplasm (GO:0005737) 8910301 golgi apparatus membrane 9 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms TSTD1 HGNC:35410 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 Q8NFU3 Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes. cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms TSTD2 HGNC:30087 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 Q5T7W7 nucleus 60 0 nucleus nucleus Deuterostomia Cell.Organisms Cell.Organisms TSTD3 HGNC:40910 thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 H0UI37 cytoplasm 24 0 cytoplasm cytoplasm NA NA NA TTBK1 HGNC:19140 tau tubulin kinase 1 Q5TCY1 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms TTBK2 HGNC:19141 tau tubulin kinase 2 Q6IQ55 Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. cytoplasm 55 1 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms TTC1 HGNC:12391 tetratricopeptide repeat domain 1 Q99614 cytoplasm 18 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TTC12 HGNC:23700 tetratricopeptide repeat domain 12 Q9H892 cytoplasm 16 1 cytoplasm cytoplasm Euteleostomi Eukaryota NA TTC13 HGNC:26204 tetratricopeptide repeat domain 13 Q8NBP0 cytoplasm 12 1 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms TTC14 HGNC:24697 tetratricopeptide repeat domain 14 Q96N46 mitochondrion membrane 9 1 mitochondrion membrane mitochondrion membrane Euteleostomi Bilateria Cell.Organisms TTC16 HGNC:26536 tetratricopeptide repeat domain 16 Q8NEE8 nucleus 7 0 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms TTC17 HGNC:25596 tetratricopeptide repeat domain 17 Q96AE7 endoplasmic reticulum 40 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms TTC18 HGNC:30726 tetratricopeptide repeat domain 18 Q5T0N1 nucleus 13 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms TTC19 HGNC:26006 tetratricopeptide repeat domain 19 Q6DKK2 Mitochondrion inner membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=According to some authors, localizes to the centrosome during all stages of the cell cycle and is recruited to the midbody during cytokinesis (PubMed:20208530). However, the midbody localization could not be confirmed by others (PubMed:21278747). mitochondrion 10 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms TTC21A HGNC:30761 tetratricopeptide repeat domain 21A Q8NDW8 cytoplasm 40 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms TTC21B HGNC:25660 tetratricopeptide repeat domain 21B Q7Z4L5 Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 82 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms TTC22 HGNC:26067 tetratricopeptide repeat domain 22 Q5TAA0 cytoplasm 34 0 cytoplasm cytoplasm Theria Chordata Deuterostomia TTC23 HGNC:25730 tetratricopeptide repeat domain 23 Q5W5X9 cytoplasm 30 0 cytoplasm cytoplasm Mammalia Deuterostomia NA TTC23L HGNC:26355 tetratricopeptide repeat domain 23-like Q6PF05 Cytoplasm (GO:0005737) cytoplasm 39 0 cytoplasm cytoplasm Theria Tetrapoda Metazoa TTC24 HGNC:32348 tetratricopeptide repeat domain 24 A2A3L6 nucleus 25 0 nucleus nucleus Theria Deuterostomia Cell.Organisms TTC25 HGNC:25280 tetratricopeptide repeat domain 25 Q96NG3 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16381901,17081983 cytoplasm 8 0 cytoplasm. nucleus multiple NA NA NA TTC26 HGNC:21882 tetratricopeptide repeat domain 26 A0AVF1 Cell projection, cilium (By similarity). Note=Localizes at the base to the ciliary transition zone (By similarity). cytoplasm 39 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TTC27 HGNC:25986 tetratricopeptide repeat domain 27 Q6P3X3 nucleus 18 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms TTC28 HGNC:29179 tetratricopeptide repeat domain 28 Q96AY4 Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Midbody (By similarity). Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). cytoplasm 15 2 cytoplasm cytoplasm Mammalia Cell.Organisms Cell.Organisms TTC29 HGNC:29936 tetratricopeptide repeat domain 29 Q8NA56 cytoplasm 30 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TTC3 HGNC:12393 tetratricopeptide repeat domain 3 P53804 Nucleus. Nucleus (GO:0005634) 17081983 nucleus 100 1 nucleus nucleus Chordata Chordata Eukaryota TTC30A HGNC:25853 tetratricopeptide repeat domain 30A Q86WT1 Cell projection, cilium (By similarity). nucleus 27 1 nucleus nucleus Bilateria Eukaryota Eukaryota TTC30B HGNC:26425 tetratricopeptide repeat domain 30B Q8N4P2 Cell projection, cilium (By similarity). nucleus 32 1 nucleus nucleus Bilateria Eukaryota Eukaryota TTC31 HGNC:25759 tetratricopeptide repeat domain 31 Q49AM3 nucleus 20 0 nucleus nucleus Catarrhini Eutheria Cell.Organisms TTC32 HGNC:32954 tetratricopeptide repeat domain 32 Q5I0X7 mitochondrion membrane 19 0 mitochondrion membrane mitochondrion membrane Euteleostomi Deuterostomia Cell.Organisms TTC33 HGNC:29959 tetratricopeptide repeat domain 33 Q6PID6 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms TTC34 HGNC:34297 tetratricopeptide repeat domain 34 A8MYJ7 endoplasmic reticulum 48 0 endoplasmic reticulum endoplasmic reticulum Chordata Chordata Cell.Organisms TTC36 HGNC:33708 tetratricopeptide repeat domain 36 A6NLP5 endoplasmic reticulum 22 0 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria NA TTC37 HGNC:23639 tetratricopeptide repeat domain 37 Q6PGP7 Cytoplasm. Nucleus. cytoplasm 9 3 cytoplasm. nucleus multiple Opisthokonta Cell.Organisms Cell.Organisms TTC38 HGNC:26082 tetratricopeptide repeat domain 38 Q5R3I4 cytoplasm 65 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms TTC39A HGNC:18657 tetratricopeptide repeat domain 39A Q5SRH9 cytoplasm 58 2 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms TTC39B HGNC:23704 tetratricopeptide repeat domain 39B Q5VTQ0 nucleus 48 4 nucleus nucleus Bilateria Eukaryota Cell.Organisms TTC39C HGNC:26595 tetratricopeptide repeat domain 39C Q8N584 cytoplasm 58 4 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota TTC4 HGNC:12394 tetratricopeptide repeat domain 4 O95801 cytoplasm 15 0 cytoplasm cytoplasm NA NA Cell.Organisms TTC40 HGNC:25247 tetratricopeptide repeat domain 40 Q8IYW2 nucleus 24 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota TTC5 HGNC:19274 tetratricopeptide repeat domain 5 Q8N0Z6 Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm (By similarity). cytoplasm 37 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms TTC6 HGNC:19739 tetratricopeptide repeat domain 6 Q86TZ1 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms TTC7A HGNC:19750 tetratricopeptide repeat domain 7A Q9ULT0 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 5 0 cytoplasm. nucleus multiple Bilateria Cell.Organisms Cell.Organisms TTC7B HGNC:19858 tetratricopeptide repeat domain 7B Q86TV6 cytoplasm 6 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms TTC8 HGNC:20087 tetratricopeptide repeat domain 8 Q8TAM2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Note=Localizes to nonmembranous centriolar satellites in the cytoplasm. Centrosome (GO:0005813) 14520415 nucleus 9 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms TTC9 HGNC:20267 tetratricopeptide repeat domain 9 Q92623 Endoplasmic reticulum (GO:0005783) 16678794 cytoplasm 17 0 endoplasmic reticulum endoplasmic reticulum Theria Euteleostomi Eukaryota TTC9B HGNC:26395 tetratricopeptide repeat domain 9B Q8N6N2 cytoplasm 17 0 cytoplasm cytoplasm Mammalia Euteleostomi Opisthokonta TTC9C HGNC:28432 tetratricopeptide repeat domain 9C Q8N5M4 cytoplasm 19 0 cytoplasm cytoplasm Eutheria Eukaryota Eukaryota TTF1 HGNC:12397 transcription termination factor, RNA polymerase I Q15361 Nucleus. Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 12684771,15561729 nucleus 40 0 nucleus nucleus Amniota Euteleostomi Eukaryota TTF2 HGNC:12398 transcription termination factor, RNA polymerase II Q9UNY4 Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis. Nucleus (GO:0005634) 12927788 nucleus 18 1 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms TTI1 HGNC:29029 TELO2 interacting protein 1 O43156 Cytoplasm. Cytoplasm (GO:0005737) 17081983 cytoplasm 100 2 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota TTI2 HGNC:26262 TELO2 interacting protein 2 Q6NXR4 nucleus 50 0 nucleus nucleus Theria Deuterostomia Opisthokonta TTK HGNC:12401 TTK protein kinase P33981 Centrosome (GO:0005813) 12686615 cytoplasm 13 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms TTL HGNC:21586 tubulin tyrosine ligase Q8NG68 cytoplasm 15 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms TTLL1 HGNC:1312 tubulin tyrosine ligase-like family, member 1 O95922 Cytoplasm, cytoskeleton (Probable). cytoplasm 44 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TTLL10 HGNC:26693 tubulin tyrosine ligase-like family, member 10 Q6ZVT0 mitochondrion 19 0 mitochondrion mitochondrion Tetrapoda Eukaryota Cell.Organisms TTLL11 HGNC:18113 tubulin tyrosine ligase-like family, member 11 Q8NHH1 Cytoplasm, cytoskeleton, cilium basal body (By similarity). cytoplasm 72 1 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms TTLL12 HGNC:28974 tubulin tyrosine ligase-like family, member 12 Q14166 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 13 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms TTLL13 HGNC:32484 tubulin tyrosine ligase-like family, member 13 A6NNM8 cytoplasm 27 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TTLL2 HGNC:21211 tubulin tyrosine ligase-like family, member 2 Q9BWV7 cytoplasm 21 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TTLL3 HGNC:24483 tubulin tyrosine ligase-like family, member 3 Q9Y4R7 Cytoplasm, cytoskeleton (By similarity). Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 26 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TTLL4 HGNC:28976 tubulin tyrosine ligase-like family, member 4 Q14679 Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Located in cilia. In some cells, also found in basal bodies (By similarity). cytoplasm 24 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms TTLL5 HGNC:19963 tubulin tyrosine ligase-like family, member 5 Q6EMB2 Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Nucleus. Cytoplasm. Note=In ciliated cells, located in both cilia and basal bodies (By similarity). In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. Nucleus (GO:0005634) 17081983 cytoplasm 28 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms TTLL6 HGNC:26664 tubulin tyrosine ligase-like family, member 6 Q8N841 Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=CEP41 is required for its transport between the basal body and the cilium. cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms TTLL7 HGNC:26242 tubulin tyrosine ligase-like family, member 7 Q6ZT98 Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cell projection, dendrite (By similarity). Perikaryon (By similarity). Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon (By similarity). cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Cell.Organisms TTLL8 HGNC:34000 tubulin tyrosine ligase-like family, member 8 A6PVC2 Cytoplasm, cytoskeleton (By similarity). Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). cytoplasm 23 0 cytoplasm cytoplasm NA NA Cell.Organisms TTLL9 HGNC:16118 tubulin tyrosine ligase-like family, member 9 Q3SXZ7 Cytoplasm, cytoskeleton, cilium basal body (By similarity). Cytoplasm, cytoskeleton (By similarity). cytoplasm 88 0 cytoplasm cytoplasm Mammalia Eukaryota Cell.Organisms TTN HGNC:12403 titin Q8WZ42 Cytoplasm (Probable). Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Sarcoplasmic reticulum (GO:0016529) 12187564,12187564,16962094 cytoplasm 26 0 cytoplasm. endoplasmic reticulum. nucleus multiple Bilateria Cell.Organisms Cell.Organisms TTPA HGNC:12404 tocopherol (alpha) transfer protein P49638 Cytoplasm. Cytoplasm (GO:0005737) 7887897 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota TTPAL HGNC:16114 tocopherol (alpha) transfer protein-like Q9BTX7 cytoplasm 23 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota TTR HGNC:12405 transthyretin P02766 Secreted. Cytoplasm. Extracellular (GO:0005576) 10854215,16199891,16188874 secreted 84 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Cell.Organisms TTYH1 HGNC:13476 tweety family member 1 Q9H313 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) plasma membrane 90 5 plasma membrane plasma membrane Mammalia Euteleostomi NA TTYH2 HGNC:13877 tweety family member 2 Q9BSA4 Cell membrane; Multi-pass membrane protein (By similarity). Plasma membrane (GO:0005886); Perinuclear region (GO:0048471) 11597145,,18577513, plasma membrane 29 5 cytoplasm. plasma membrane multiple Euteleostomi Bilateria Holozoa TTYH3 HGNC:22222 tweety family member 3 Q9C0H2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 5 plasma membrane plasma membrane Euteleostomi Bilateria Holozoa TUB HGNC:12406 tubby bipartite transcription factor P50607 Cytoplasm (By similarity). Nucleus (By similarity). Secreted (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Cytoplasm (GO:0005737); Nucleolus (GO:0005730);Nucleus (GO:0005634);Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11000483,11000483/11000483/11375483,10455176,11375483,10455176 cytoplasm 38 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TUBA1A HGNC:20766 tubulin, alpha 1a Q71U36 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microtubule (GO:0005874); Nucleus (GO:0005634) 11964161,17081983,12429849,15561729,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TUBA1B HGNC:18809 tubulin, alpha 1b P68363 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Plasma membrane (GO:0005886) 11580271,12087096,15556606 cytoplasm 100 0 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms TUBA1C HGNC:20768 tubulin, alpha 1c Q9BQE3 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Microtubule (GO:0005874); Nucleus (GO:0005634) none,17081983,15561729,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TUBA3C HGNC:12408 tubulin, alpha 3c Q13748 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 11278332 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBA3D HGNC:24071 tubulin, alpha 3d Q13748 Cytoplasm, cytoskeleton. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBA3E HGNC:20765 tubulin, alpha 3e Q6PEY2 Cytoplasm, cytoskeleton (By similarity). cytoplasm 98 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBA4A HGNC:12407 tubulin, alpha 4a P68366 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Microtubule (GO:0005874) ,15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBA8 HGNC:12410 tubulin, alpha 8 Q9NY65 Cytoplasm, cytoskeleton. Cytoskeleton (GO:0005856); Microtubule (GO:0005874) ,15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBAL3 HGNC:23534 tubulin, alpha-like 3 A6NHL2 Cytoplasm, cytoskeleton (By similarity). cytoplasm 69 0 cytoplasm cytoplasm Eukaryota Eukaryota NA TUBB HGNC:20778 tubulin, beta class I P07437 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Kinetochore (GO:0000776) 12211114,12214803,15556606,11780067 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota NA TUBB1 HGNC:16257 tubulin, beta 1 class VI Q9H4B7 Cytoplasm, cytoskeleton. Nucleolus (GO:0005730); Microtubule (GO:0005874) 11790298,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TUBB2A HGNC:12412 tubulin, beta 2A class IIa Q13885 Cytoplasm, cytoskeleton (By similarity). cytoplasm 99 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBB2B HGNC:30829 tubulin, beta 2B class IIb Q9BVA1 Cytoplasm, cytoskeleton (By similarity). cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBB3 HGNC:20772 tubulin, beta 3 class III Q13509 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737) 7789418 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBB4A HGNC:20774 tubulin, beta 4A class IVa P04350 Cytoplasm, cytoskeleton. Microtubule (GO:0005874) 15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBB4B HGNC:20771 tubulin, beta 4B class IVb P68371 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Microtubule (GO:0005874) 11118478,15635413,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TUBB6 HGNC:20776 tubulin, beta 6 class V Q9BUF5 Cytoplasm, cytoskeleton (By similarity). cytoplasm 98 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms TUBB8 HGNC:20773 tubulin, beta 8 class VIII Q3ZCM7 Cytoplasm, cytoskeleton (By similarity). cytoplasm 89 0 cytoplasm cytoplasm NA NA NA TUBD1 HGNC:16811 tubulin, delta 1 Q9UJT1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Nucleus. Note=Associated with centrioles. Both cytoplasmic and nuclear. Centrosome (GO:0005813) 10620804 cytoplasm 9 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms TUBE1 HGNC:20775 tubulin, epsilon 1 Q9UJT0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with pericentriolar material. Centrosome (GO:0005813) 10620804 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Eukaryota NA TUBG1 HGNC:12417 tubulin, gamma 1 P23258 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus (GO:0005634); Nucleolus (GO:0005730); Centrosome (GO:0005813); Cytosol (GO:0005829) ,9566969,17891179,,11790298,15635413,,17139249,15561729,17891179,,,17891179, cytoplasm 21 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TUBG2 HGNC:12419 tubulin, gamma 2 Q9NRH3 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (Probable). Nucleus (GO:0005634) 9566969 cytoplasm 21 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TUBGCP2 HGNC:18599 tubulin, gamma complex associated protein 2 Q9BSJ2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813); Cytoplasm (GO:0005737) 9566967,15561729,9566967 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TUBGCP3 HGNC:18598 tubulin, gamma complex associated protein 3 Q96CW5 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Centrosome (GO:0005813) 9566969,9566969,9566967,15561729 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota TUBGCP4 HGNC:16691 tubulin, gamma complex associated protein 4 Q9UGJ1 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813) 10562286,16413547,15561729 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota TUBGCP5 HGNC:18600 tubulin, gamma complex associated protein 5 Q96RT8 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813) 11694571,15561729 cytoplasm 100 0 cytoplasm cytoplasm Theria Eukaryota Eukaryota TUBGCP6 HGNC:18127 tubulin, gamma complex associated protein 6 Q96RT7 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Centrosome (GO:0005813);Centrosome (GO:0005813) 15561729/11694571 cytoplasm 100 3 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota TUFM HGNC:12420 Tu translation elongation factor, mitochondrial P49411 Mitochondrion. Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 9332382,15561729,15635413,11790298 mitochondrion 100 0 mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms TUFT1 HGNC:12422 tuftelin 1 Q9NNX1 Secreted (By similarity). Note=Secreted at a very early stage of enamel formation, concentrated at the dentin- enamel junction and tightly bound to the surface of the growing crystallites (By similarity). Extracellular (GO:0005576) 11733143 secreted 86 0 secreted secreted Amniota Euteleostomi Chordata TULP1 HGNC:12423 tubby like protein 1 O00294 Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Secreted (By similarity). Cell junction, synapse (By similarity). Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10607826,1000483,11481257,10549638,1000483 cytoplasm 53 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota TULP2 HGNC:12424 tubby like protein 2 O00295 Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). cytoplasm 40 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota TULP3 HGNC:12425 tubby like protein 3 O75386 Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11375483,10509669,11375483 cytoplasm 39 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota TULP4 HGNC:15530 tubby like protein 4 Q9NRJ4 Cytoplasm. Cytoplasm (GO:0005737) 11595174 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms TUSC1 HGNC:31010 tumor suppressor candidate 1 Q2TAM9 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 81 0 cytoplasm. nucleus multiple Theria Amniota Amniota TUSC2 HGNC:17034 tumor suppressor candidate 2 O75896 Cytoplasm (GO:0005737) 11085536 nucleus 37 0 cytoplasm cytoplasm Deuterostomia Bilateria NA TUSC3 HGNC:30242 tumor suppressor candidate 3 Q13454 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Extracellular (GO:0005576); Integral to membrane (GO:0016021) 14718574,8661104 endoplasmic reticulum membrane 8 4 secreted secreted Opisthokonta Eukaryota Eukaryota TUSC5 HGNC:29592 tumor suppressor candidate 5 Q8IXB3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 91 2 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi TUT1 HGNC:26184 terminal uridylyl transferase 1, U6 snRNA-specific Q9H6E5 Nucleus, nucleolus. Nucleus speckle. nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota TVP23A HGNC:20398 trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) A6NH52 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 23 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota TVP23B HGNC:20399 trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) Q9NYZ1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 19 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota TVP23C HGNC:30453 trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) Q96ET8 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 16 3 golgi apparatus membrane golgi apparatus membrane Theria Theria Eukaryota TWF1 HGNC:9620 twinfilin actin-binding protein 1 Q12792 Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). Actin cytoskeleton (GO:0015629); Cytoplasm (GO:0005737) 12207032,12807912,12807912 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota TWF2 HGNC:9621 twinfilin actin-binding protein 2 Q6IBS0 Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium (By similarity). Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Cytoplasm (GO:0005737) 10406962 cytoplasm 58 0 cytoplasm cytoplasm NA NA Eukaryota TWIST1 HGNC:12428 twist family bHLH transcription factor 1 Q15672 Nucleus. Nucleus (GO:0005634) 8995765 nucleus 100 0 nucleus nucleus Bilateria Bilateria Metazoa TWIST2 HGNC:20670 twist family bHLH transcription factor 2 Q8WVJ9 Nucleus. Cytoplasm. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11062344,11062344 nucleus 76 0 cytoplasm. nucleus multiple NA NA Metazoa TWISTNB HGNC:18027 TWIST neighbor Q3B726 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 12438708,17081983 nucleus 14 0 nucleus nucleus Chordata Eukaryota Eukaryota TWSG1 HGNC:12429 twisted gastrulation BMP signaling modulator 1 Q9GZX9 Secreted (By similarity). Extracellular (GO:0005576) 14681194 secreted 79 0 secreted secreted Deuterostomia Bilateria Bilateria TXK HGNC:12434 TXK tyrosine kinase P42681 Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells. Cytoplasm (GO:0005737) 7951233 cytoplasm 46 0 cytoplasm. nucleus multiple Chordata Bilateria Cell.Organisms TXLNA HGNC:30685 taxilin alpha P40222 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 12558796,17081983,12558796,17081983 cytoplasm 46 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota TXLNB HGNC:21617 taxilin beta Q8N3L3 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12372618,12372618 cytoplasm 62 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota TXLNG HGNC:18578 taxilin gamma Q9NUQ3 Nucleus membrane. Cytoplasm, cytosol (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 49 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota TXN HGNC:12435 thioredoxin P10599 Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 9915858,9915858,12529245 cytoplasm 52 0 cytoplasm. nucleus. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms TXN2 HGNC:17772 thioredoxin 2 Q99757 Mitochondrion. Mitochondrion (GO:0005739) 12032145 mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms TXNDC11 HGNC:28030 thioredoxin domain containing 11 Q6PKC3 Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). cytoplasm 22 1 cytoplasm cytoplasm Tetrapoda Bilateria Cell.Organisms TXNDC12 HGNC:24626 thioredoxin domain containing 12 (endoplasmic reticulum) O95881 Endoplasmic reticulum lumen. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 14557066,12761212,15598749 endoplasmic reticulum 100 0 endoplasmic reticulum. golgi apparatus. mitochondrion multiple Amniota Eukaryota Cell.Organisms TXNDC15 HGNC:20652 thioredoxin domain containing 15 Q96J42 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) 12975309 endoplasmic reticulum 21 1 endoplasmic reticulum endoplasmic reticulum Deuterostomia Bilateria Cell.Organisms TXNDC16 HGNC:19965 thioredoxin domain containing 16 Q9P2K2 Secreted (Potential). endoplasmic reticulum 10 1 endoplasmic reticulum endoplasmic reticulum Deuterostomia Deuterostomia Eukaryota TXNDC17 HGNC:28218 thioredoxin domain containing 17 Q9BRA2 Cytoplasm. Cytoplasm (GO:0005737) 14607844 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota TXNDC2 HGNC:16470 thioredoxin domain containing 2 (spermatozoa) Q86VQ3 Cytoplasm. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece. Cytoplasm (GO:0005737) 11399755 cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eukaryota Cell.Organisms TXNDC5 HGNC:21073 thioredoxin domain containing 5 (endoplasmic reticulum) Q8NBS9 Endoplasmic reticulum lumen (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 12878160,12930873,12878160,12930873 endoplasmic reticulum 82 0 endoplasmic reticulum. golgi apparatus multiple NA NA Cell.Organisms TXNDC8 HGNC:31454 thioredoxin domain containing 8 (spermatozoa) Q6A555 Cytoplasm. Golgi apparatus. Golgi apparatus (GO:0005794) 15181017 cytoplasm 32 0 cytoplasm. golgi apparatus multiple Euarchontoglires Eukaryota Cell.Organisms TXNDC9 HGNC:24110 thioredoxin domain containing 9 O14530 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813) 15009089,15009089,15009089 mitochondrion 22 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms TXNIP HGNC:16952 thioredoxin interacting protein Q9H3M7 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11753387,12386145,12821938 cytoplasm 96 0 cytoplasm. nucleus multiple Theria Euteleostomi Opisthokonta TXNL1 HGNC:12436 thioredoxin-like 1 O43396 Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated. Cytoplasm (GO:0005737) 10826702 cytoplasm 23 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms TXNL4A HGNC:30551 thioredoxin-like 4A P83876 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota TXNL4B HGNC:26041 thioredoxin-like 4B Q9NX01 Nucleus. Nucleus (GO:0005634) 15161931 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms TXNRD1 HGNC:12437 thioredoxin reductase 1 Q16881 Cytoplasm (By similarity). Isoform 4: Cytoplasm. Nucleus. Isoform 5: Cytoplasm. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11410332,15879598,10786696,10786696,15879598 cytoplasm 88 0 cytoplasm. nucleus. secreted multiple Eukaryota Cell.Organisms Cell.Organisms TXNRD2 HGNC:18155 thioredoxin reductase 2 Q9NNW7 Mitochondrion. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 10215850,10215850 mitochondrion 100 0 mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms TXNRD3 HGNC:20667 thioredoxin reductase 3 Q86VQ6 Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity). Note=Detected in cytoplasm and nucleus in late spermatids (By similarity). cytoplasm 68 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms TXNRD3NB HGNC:33870 thioredoxin reductase 3 neighbor Q6F5E7 secreted 61 0 secreted secreted Human Human Homo TYK2 HGNC:12440 tyrosine kinase 2 P29597 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10673353,11399767 cytoplasm 19 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms TYMP HGNC:3148 thymidine phosphorylase P19971 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 11297264,11041061,10472757,11041061,10472757, cytoplasm 48 0 cytoplasm. nucleus. secreted multiple Euarchontoglires Cell.Organisms Cell.Organisms TYMS HGNC:12441 thymidylate synthetase P04818 Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 11747337,1720706,9148948,9148948 nucleus 56 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms TYR HGNC:12442 tyrosinase P14679 Melanosome membrane; Single-pass type I membrane protein. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 10823941,10823941,10823941 secreted 15 1 cytoplasm. endoplasmic reticulum. golgi apparatus. melanosome membrane multiple Chordata Cell.Organisms Cell.Organisms TYRO3 HGNC:12446 TYRO3 protein tyrosine kinase Q06418 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 8108112 plasma membrane 100 1 plasma membrane plasma membrane Chordata Chordata Cell.Organisms TYROBP HGNC:12449 TYRO protein tyrosine kinase binding protein O43914 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Cell surface (GO:0009986); Cytoplasm (GO:0005737) 9490415,9490415,9490415 plasma membrane 46 1 cytoplasm. plasma membrane multiple Mammalia Mammalia Euteleostomi TYRP1 HGNC:12450 tyrosinase-related protein 1 P17643 Melanosome membrane; Single-pass type I membrane protein (By similarity). Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity). Endosome (GO:0005768); Golgi apparatus (GO:0005794) 11441007,11441007 secreted 18 1 endosome. golgi apparatus multiple Chordata Opisthokonta Cell.Organisms TYSND1 HGNC:28531 trypsin domain containing 1 Q2T9J0 Peroxisome. peroxisome 100 4 peroxisome peroxisome Tetrapoda Eukaryota Cell.Organisms TYW1 HGNC:25598 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) Q9NV66 endoplasmic reticulum 34 1 endoplasmic reticulum endoplasmic reticulum Cell.Organisms Cell.Organisms Cell.Organisms TYW1B HGNC:33908 tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) Q6NUM6 endoplasmic reticulum 30 1 endoplasmic reticulum endoplasmic reticulum NA NA NA TYW3 HGNC:24757 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) Q6IPR3 nucleus 71 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms TYW5 HGNC:26754 tRNA-yW synthesizing protein 5 A2RUC4 cytoplasm 15 0 cytoplasm cytoplasm Amniota Eukaryota Cell.Organisms U2AF1 HGNC:12453 U2 small nuclear RNA auxiliary factor 1 Q01081 Nucleus. Nucleus speckle. Nucleoplasm (GO:0005654); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1388271,1388271,11118443,11118443 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota U2AF1L4 HGNC:23020 U2 small nuclear RNA auxiliary factor 1-like 4 Q8WU68 Nucleus (By similarity). Nucleus speckle (By similarity). Nucleus (GO:0005634) nucleus 93 0 nucleus nucleus Eukaryota Eukaryota Eukaryota U2AF2 HGNC:23156 U2 small nuclear RNA auxiliary factor 2 P26368 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11118443,1388271,19059367,11118443,15635413,11790298 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eukaryota Cell.Organisms U2SURP HGNC:30855 U2 snRNP-associated SURP domain containing O15042 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms UACA HGNC:15947 uveal autoantigen with coiled-coil domains and ankyrin repeats Q9BZF9 Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Expressed diffusely in cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15358194,15358194 nucleus 17 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms UAP1 HGNC:12457 UDP-N-acteylglucosamine pyrophosphorylase 1 Q16222 Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail. Cytoplasm (GO:0005737) 8025165 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms UAP1L1 HGNC:28082 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 Q3KQV9 cytoplasm 49 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms UBA1 HGNC:12469 ubiquitin-like modifier activating enzyme 1 P22314 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829) 11846513,8663123,11846513,8663123,16263121,15561729 nucleus 32 1 cytoplasm. nucleus multiple Eukaryota Eukaryota NA UBA2 HGNC:30661 ubiquitin-like modifier activating enzyme 2 Q9UBT2 Nucleus. nucleus 32 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms UBA3 HGNC:12470 ubiquitin-like modifier activating enzyme 3 Q8TBC4 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10207026,10207026 nucleus 31 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms UBA5 HGNC:23230 ubiquitin-like modifier activating enzyme 5 Q9GZZ9 Cytoplasm. Nucleus. Note=Localizes mainly in cytoplasm, while it mainly localizes to the nucleus in presence of SUMO2. Integral to membrane (GO:0016021) nucleus 10 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms UBA52 HGNC:12458 ubiquitin A-52 residue ribosomal protein fusion product 1 P62987 Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity). 60S ribosomal protein L40: Cytoplasm (By similarity). Ribosome (GO:0005840); Extracellular (GO:0005576) 1850507,16199891 nucleus 47 0 secreted secreted NA NA Cell.Organisms UBA6 HGNC:25581 ubiquitin-like modifier activating enzyme 6 A0AVT1 nucleus 20 3 nucleus nucleus Eukaryota Eukaryota Cell.Organisms UBA7 HGNC:12471 ubiquitin-like modifier activating enzyme 7 P41226 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10709110,10709110 nucleus 23 1 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms UBAC1 HGNC:30221 UBA domain containing 1 Q9BSL1 Cytoplasm. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Nucleus (GO:0005634); Cytoskeleton (GO:0005856) 10857748,10857748,10857748,10857748 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota UBAC2 HGNC:20486 UBA domain containing 2 Q8NBM4 Membrane; Multi-pass membrane protein (Potential). mitochondrion membrane 23 4 mitochondrion membrane mitochondrion membrane Euteleostomi Eukaryota Eukaryota UBALD1 HGNC:29576 UBA-like domain containing 1 Q8TB05 nucleus 57 0 nucleus nucleus Theria Deuterostomia Eumetazoa UBALD2 HGNC:28438 UBA-like domain containing 2 Q8IYN6 cytoplasm 39 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Holozoa UBAP1 HGNC:12461 ubiquitin associated protein 1 Q9NZ09 Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex. cytoplasm 39 0 cytoplasm. endosome multiple Deuterostomia Deuterostomia Metazoa UBAP1L HGNC:40028 ubiquitin associated protein 1-like F5GYI3 secreted 6 0 secreted secreted NA NA Eumetazoa UBAP2 HGNC:14185 ubiquitin associated protein 2 Q5T6F2 cytoplasm 24 0 cytoplasm cytoplasm Chordata Bilateria Metazoa UBAP2L HGNC:29877 ubiquitin associated protein 2-like Q14157 Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 23 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Metazoa UBASH3A HGNC:12462 ubiquitin associated and SH3 domain containing A P57075 Cytoplasm. Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 11281453/15107835 cytoplasm 34 0 cytoplasm. nucleus multiple Amniota Amniota Cell.Organisms UBASH3B HGNC:29884 ubiquitin associated and SH3 domain containing B Q8TF42 Cytoplasm (By similarity). Nucleus (Potential). cytoplasm 43 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms UBB HGNC:12463 ubiquitin B P0CG47 Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 3029682,6092831,6275256,11790298 nucleus 47 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms UBC HGNC:12468 ubiquitin C P0CG48 Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasm (GO:0005737) 12813030 nucleus 47 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms UBD HGNC:18795 ubiquitin D O15205 Nucleus. Cytoplasm (By similarity). Note=Accumulates in aggresomes under proteasome inhibition conditions. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12730673,10200259 nucleus 17 0 cytoplasm. nucleus multiple Mammalia Mammalia NA UBE2A HGNC:12472 ubiquitin-conjugating enzyme E2A P49459 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1717990,12640129,11929833 nucleus 85 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2B HGNC:12473 ubiquitin-conjugating enzyme E2B P63146 Cell membrane (By similarity). Nucleus (By similarity). Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 1559696,11929833 nucleus 83 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2C HGNC:15937 ubiquitin-conjugating enzyme E2C O00762 Nucleus (GO:0005634) 11927573 cytoplasm 58 0 nucleus nucleus Theria Eukaryota Eukaryota UBE2D1 HGNC:12474 ubiquitin-conjugating enzyme E2D 1 P51668 Cytoplasm. Nucleus (GO:0005634) 9182527 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2D2 HGNC:12475 ubiquitin-conjugating enzyme E2D 2 P62837 Cytoplasm (GO:0005737) 9990509 cytoplasm 86 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UBE2D3 HGNC:12476 ubiquitin-conjugating enzyme E2D 3 P61077 Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Perinuclear region (GO:0048471); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9990509,9990509,9990509 cytoplasm 86 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2D4 HGNC:21647 ubiquitin-conjugating enzyme E2D 4 (putative) Q9Y2X8 cytoplasm 90 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UBE2E1 HGNC:12477 ubiquitin-conjugating enzyme E2E 1 P51965 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11322894,10991948 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota UBE2E2 HGNC:12478 ubiquitin-conjugating enzyme E2E 2 Q96LR5 nucleus 88 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota UBE2E3 HGNC:12479 ubiquitin-conjugating enzyme E2E 3 Q969T4 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner. Nucleus (GO:0005634) nucleus 85 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota UBE2F HGNC:12480 ubiquitin-conjugating enzyme E2F (putative) Q969M7 cytoplasm 17 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota UBE2G1 HGNC:12482 ubiquitin-conjugating enzyme E2G 1 P62253 Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11278356,11278356,9693041 nucleus 24 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2G2 HGNC:12483 ubiquitin-conjugating enzyme E2G 2 P60604 Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 9693041,10991948,11278356 nucleus 26 0 cytoplasm. endoplasmic reticulum. nucleus multiple Opisthokonta Eukaryota NA UBE2H HGNC:12484 ubiquitin-conjugating enzyme E2H P62256 Nucleus (GO:0005634) cytoplasm 49 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UBE2I HGNC:12485 ubiquitin-conjugating enzyme E2I P63279 Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12192048,12192048,15635413,15598749 nucleus 58 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2J1 HGNC:17598 ubiquitin-conjugating enzyme E2, J1 Q9Y385 Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum (GO:0005783) 12082160 endoplasmic reticulum membrane 100 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Eukaryota Eukaryota Eukaryota UBE2J2 HGNC:19268 ubiquitin-conjugating enzyme E2, J2 Q8N2K1 Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic reticulum membrane (GO:0005789) 11278356 endoplasmic reticulum membrane 93 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota UBE2K HGNC:4914 ubiquitin-conjugating enzyme E2K P61086 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 8702625 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Eukaryota UBE2L3 HGNC:12488 ubiquitin-conjugating enzyme E2L 3 P68036 Nucleus. Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 11278816,11278816,11278816 cytoplasm 24 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota UBE2L6 HGNC:12490 ubiquitin-conjugating enzyme E2L 6 O14933 cytoplasm 25 0 cytoplasm cytoplasm Eutheria Eutheria Eukaryota UBE2M HGNC:12491 ubiquitin-conjugating enzyme E2M P61081 cytoplasm 14 0 cytoplasm cytoplasm Eutheria Eukaryota Eukaryota UBE2N HGNC:12492 ubiquitin-conjugating enzyme E2N P61088 Nucleus. Cytoplasm. Nucleus (GO:0005634); Plasma membrane (GO:0005886); Cytosol (GO:0005829) 10089880,,19898473,,,19898473, cytoplasm 35 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2NL HGNC:31710 ubiquitin-conjugating enzyme E2N-like Q5JXB2 cytoplasm 31 0 cytoplasm cytoplasm Homininae Homininae Eukaryota UBE2O HGNC:29554 ubiquitin-conjugating enzyme E2O Q9C0C9 Cytoplasm (GO:0005737) peroxisome 15 0 peroxisome peroxisome Amniota Eukaryota Eukaryota UBE2Q1 HGNC:15698 ubiquitin-conjugating enzyme E2Q family member 1 Q7Z7E8 cytoplasm 71 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota UBE2Q2 HGNC:19248 ubiquitin-conjugating enzyme E2Q family member 2 Q8WVN8 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16300736,16300736 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota UBE2Q2L HGNC:44656 ubiquitin-conjugating enzyme E2Q family member 2-like H0YL09 cytoplasm 66 0 cytoplasm cytoplasm NA NA Primates UBE2QL1 HGNC:37269 ubiquitin-conjugating enzyme E2Q family-like 1 A1L167 cytoplasm 43 0 cytoplasm cytoplasm Homininae Opisthokonta Eukaryota UBE2R2 HGNC:19907 ubiquitin-conjugating enzyme E2R 2 Q712K3 nucleus 26 0 nucleus nucleus Bilateria Eukaryota Eukaryota UBE2S HGNC:17895 ubiquitin-conjugating enzyme E2S Q16763 cytoplasm 20 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota UBE2T HGNC:25009 ubiquitin-conjugating enzyme E2T (putative) Q9NPD8 Nucleus. Note=Accumulates to chromatin. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota UBE2U HGNC:28559 ubiquitin-conjugating enzyme E2U (putative) Q5VVX9 Nucleus (GO:0005634) cytoplasm 22 0 cytoplasm cytoplasm Mammalia Mammalia Eukaryota UBE2V1 HGNC:12494 ubiquitin-conjugating enzyme E2 variant 1 Q13404 Nucleus. Note=Excluded from the nucleolus. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11076860/9305758,11076860,9305758 nucleus 100 0 cytoplasm. nucleus multiple NA NA Eukaryota UBE2V2 HGNC:12495 ubiquitin-conjugating enzyme E2 variant 2 Q15819 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9705497,9705497 nucleus 88 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBE2W HGNC:25616 ubiquitin-conjugating enzyme E2W (putative) Q96B02 Nucleus. Note=In the nucleus, colocalizes with FANCL. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota UBE2Z HGNC:25847 ubiquitin-conjugating enzyme E2Z Q9H832 Cytoplasm. Nucleus. nucleus 19 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota UBE3A HGNC:12496 ubiquitin protein ligase E3A Q05086 Nucleus (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Mitochondrion (GO:0005739) 9891052,9891052,15598749 nucleus 20 1 cytoplasm. mitochondrion. nucleus multiple Deuterostomia Eukaryota Eukaryota UBE3B HGNC:13478 ubiquitin protein ligase E3B Q7Z3V4 Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 19 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota UBE3C HGNC:16803 ubiquitin protein ligase E3C Q15386 Nucleus (Potential). nucleus 18 2 nucleus nucleus Opisthokonta Eukaryota Eukaryota UBE3D HGNC:21381 ubiquitin protein ligase E3D Q7Z6J8 Cytoplasm (Potential). nucleus 70 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota UBE4A HGNC:12499 ubiquitination factor E4A Q14139 nucleus 23 2 nucleus nucleus Eukaryota Eukaryota NA UBE4B HGNC:12500 ubiquitination factor E4B O95155 Cytoplasm (By similarity). cytoplasm 97 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UBFD1 HGNC:30565 ubiquitin family domain containing 1 O14562 nucleus 14 0 nucleus nucleus Amniota Eukaryota Eukaryota UBIAD1 HGNC:30791 UbiA prenyltransferase domain containing 1 Q9Y5Z9 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886); Endosome (GO:0005768) 12497587,11314041,12497587,11314041,12497587,12497587,11314041,12497587 mitochondrion membrane 50 10 cytoplasm. endoplasmic reticulum membrane. endosome. golgi apparatus. golgi apparatus membrane. nucleus. plasma membrane multiple Euteleostomi Cell.Organisms Cell.Organisms UBL3 HGNC:12504 ubiquitin-like 3 O95164 Cell membrane; Lipid-anchor (By similarity). cytoplasm 56 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota UBL4A HGNC:12505 ubiquitin-like 4A P11441 Cytoplasm, cytosol. cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria NA UBL4B HGNC:32309 ubiquitin-like 4B Q8N7F7 Cytoplasm (By similarity). cytoplasm 66 0 cytoplasm cytoplasm Theria Theria Cell.Organisms UBL5 HGNC:13736 ubiquitin-like 5 Q9BZL1 Cytoplasm. Cytoplasm (GO:0005737) 11161819 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UBL7 HGNC:28221 ubiquitin-like 7 Q96S82 secreted 19 0 secreted secreted Euteleostomi Bilateria Opisthokonta UBLCP1 HGNC:28110 ubiquitin-like domain containing CTD phosphatase 1 Q8WVY7 Nucleus. Note=Colocalizes with nuclear proteasomes. Nucleus (GO:0005634) 15883030 nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota UBN1 HGNC:12506 ubinuclein 1 Q9NPG3 Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10725330,17081983,10725330,10725330 nucleus 15 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Metazoa UBN2 HGNC:21931 ubinuclein 2 Q6ZU65 plasma membrane 26 0 n/a n/a Euteleostomi Deuterostomia Metazoa UBOX5 HGNC:17777 U-box domain containing 5 O94941 Nucleus (By similarity). Nucleus (GO:0005634) 11274149 nucleus 74 0 nucleus nucleus Human Bilateria Eukaryota UBP1 HGNC:12507 upstream binding protein 1 (LBP-1a) Q9NZI7 Nucleus. Nucleus (GO:0005634) 10644752,19059367 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Opisthokonta UBQLN1 HGNC:12508 ubiquilin 1 Q9UMX0 Cytoplasm. Nucleus. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12095988,11853878,15492808,11076969,15492808 endoplasmic reticulum membrane 20 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Eukaryota UBQLN2 HGNC:12509 ubiquilin 2 Q9UHD9 Cytoplasm. Nucleus. Note=Where it colocalizes with the proteasome. Associated with fibers in mitotic cells. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10983987,10983987 cytoplasm 40 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UBQLN3 HGNC:12510 ubiquilin 3 Q9H347 secreted 10 0 secreted secreted Euarchontoglires Theria Eukaryota UBQLN4 HGNC:1237 ubiquilin 4 Q9NRR5 Nucleus. Cytoplasm. Endoplasmic reticulum (Probable). Cytoplasm, perinuclear region (By similarity). Note=Colocalizes with the proteasome, both in nucleus and cytoplasm. May associate with the endoplasmic reticulum. Nucleus (GO:0005634) 11001934 cytoplasm 4 0 cytoplasm. endoplasmic reticulum. nucleus multiple Eukaryota Eukaryota Eukaryota UBQLNL HGNC:28294 ubiquilin-like Q8IYU4 cytoplasm 37 0 cytoplasm cytoplasm Theria Theria Eukaryota UBR1 HGNC:16808 ubiquitin protein ligase E3 component n-recognin 1 Q8IWV7 Cytoplasm, cytosol. cytoplasm 100 2 cytoplasm cytoplasm Opisthokonta Opisthokonta Cell.Organisms UBR2 HGNC:21289 ubiquitin protein ligase E3 component n-recognin 2 Q8IWV8 Nucleus (By similarity). Note=Associated with chromatin during meiosis. Nucleus (GO:0005634) 17081983 nucleus 88 2 nucleus nucleus Opisthokonta Opisthokonta Cell.Organisms UBR3 HGNC:30467 ubiquitin protein ligase E3 component n-recognin 3 (putative) Q6ZT12 Membrane; Multi-pass membrane protein (Potential). nucleus 7 5 nucleus nucleus Bilateria Eukaryota Eukaryota UBR4 HGNC:30313 ubiquitin protein ligase E3 component n-recognin 4 Q5T4S7 Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 16061792,17081983,16061792,17081983 nucleus 25 5 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota UBR5 HGNC:16806 ubiquitin protein ligase E3 component n-recognin 5 O95071 Nucleus. Nucleus (GO:0005634) 12011095 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota UBR7 HGNC:20344 ubiquitin protein ligase E3 component n-recognin 7 (putative) Q8N806 nucleus 25 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota UBTD1 HGNC:25683 ubiquitin domain containing 1 Q9HAC8 cytoplasm 57 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota UBTD2 HGNC:24463 ubiquitin domain containing 2 Q8WUN7 Cytoplasm. Mitochondrion (GO:0005739) 12507522 cytoplasm 100 0 cytoplasm. mitochondrion multiple Deuterostomia Eukaryota Eukaryota UBTF HGNC:12511 upstream binding transcription factor, RNA polymerase I P17480 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730); Nucleus (GO:0005634) ,11075946,2330041,15635413,11790298,17623812,15226435,,12748295 nucleus 99 0 nucleus nucleus Theria Eukaryota Eukaryota UBXN1 HGNC:18402 UBX domain protein 1 Q04323 Cytoplasm (By similarity). cytoplasm 91 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota UBXN10 HGNC:26354 UBX domain protein 10 Q96LJ8 nucleus 63 0 nucleus nucleus Theria Euteleostomi Chordata UBXN11 HGNC:30600 UBX domain protein 11 Q5T124 Cytoplasm, cytoskeleton (By similarity). Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 11940653,11940653,11940653 cytoplasm 74 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota UBXN2A HGNC:27265 UBX domain protein 2A P68543 cytoplasm 14 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota UBXN2B HGNC:27035 UBX domain protein 2B Q14CS0 Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 17141156,17141156,17141156,17141156 cytoplasm 18 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Eukaryota Eukaryota Eukaryota UBXN4 HGNC:14860 UBX domain protein 4 Q92575 Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Note=Both the N- and the C- terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. endoplasmic reticulum 15 1 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Eukaryota UBXN6 HGNC:14928 UBX domain protein 6 Q9BZV1 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the centrosome both in interphase and during mitosis. Cytoplasm (GO:0005737); Membrane fraction (GO:0005624); Nucleus (GO:0005634); Centrosome (GO:0005813);Cytoplasm (GO:0005737); Nucleus (GO:0005634); Centrosome (GO:0005813) ,18656546,,,18656546,,,18656546,,,18656546,/,18656546,,,18656546,,,18656546, cytoplasm 28 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota UBXN7 HGNC:29119 UBX domain protein 7 O94888 nucleus 36 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms UBXN8 HGNC:30307 UBX domain protein 8 O00124 Endoplasmic reticulum membrane; Multi-pass membrane protein. secreted 69 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Mammalia Deuterostomia NA UCHL1 HGNC:12513 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) P09936 Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain. Cytoplasm (GO:0005737) 6343558 cytoplasm 47 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UCHL3 HGNC:12515 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) P15374 Cytoplasm. Cytoplasm (GO:0005737) 9233788 cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UCHL5 HGNC:19678 ubiquitin carboxyl-terminal hydrolase L5 Q9Y5K5 Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17139257,17139257 nucleus 29 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UCK1 HGNC:14859 uridine-cytidine kinase 1 Q9HA47 mitochondrion 14 0 mitochondrion mitochondrion Eukaryota Cell.Organisms Cell.Organisms UCK2 HGNC:12562 uridine-cytidine kinase 2 Q9BZX2 Cytoplasm (GO:0005737) 11912132,17081983 mitochondrion 11 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms UCKL1 HGNC:15938 uridine-cytidine kinase 1-like 1 Q9NWZ5 Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12199906,12199906 mitochondrion 17 0 cytoplasm. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms UCMA HGNC:25205 upper zone of growth plate and cartilage matrix associated Q8WVF2 Secreted, extracellular space, extracellular matrix (By similarity). secreted 92 0 secreted secreted Euteleostomi Euteleostomi Craniata UCN HGNC:12516 urocortin P55089 Secreted. Extracellular (GO:0005576) 12175707,14576187 secreted 100 0 secreted secreted Theria Theria Mammalia UCN2 HGNC:18414 urocortin 2 Q96RP3 Secreted. Extracellular (GO:0005576) 11329063 secreted 100 0 secreted secreted Eutheria Eutheria Boreoeutheria UCN3 HGNC:17781 urocortin 3 Q969E3 Secreted. secreted 100 0 secreted secreted Tetrapoda Euteleostomi NA UCP1 HGNC:12517 uncoupling protein 1 (mitochondrial, proton carrier) P25874 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 12119988 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Eutheria Eutheria Eukaryota UCP2 HGNC:12518 uncoupling protein 2 (mitochondrial, proton carrier) P55851 Mitochondrion inner membrane; Multi-pass membrane protein. Mitochondrion (GO:0005739) 11780125 mitochondrion membrane 100 3 mitochondrion. mitochondrion membrane multiple Deuterostomia Eukaryota Eukaryota UCP3 HGNC:12519 uncoupling protein 3 (mitochondrial, proton carrier) P55916 Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). Mitochondrion (GO:0005739) 14671191 mitochondrion membrane 67 3 mitochondrion mitochondrion Deuterostomia Eukaryota Eukaryota UEVLD HGNC:30866 UEV and lactate/malate dehyrogenase domains Q8IX04 cytoplasm 29 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Cell.Organisms UFC1 HGNC:26941 ubiquitin-fold modifier conjugating enzyme 1 Q9Y3C8 cytoplasm 14 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota UFD1L HGNC:12520 ubiquitin fusion degradation 1 like (yeast) Q92890 Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12910480,11574150 nucleus 39 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UFL1 HGNC:23039 UFM1-specific ligase 1 O94874 Endoplasmic reticulum. Cytoplasm. Note=In cytoplasm colocalizes with CDK5RAP3. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15598749,17081983,17081983 nucleus 79 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota UFM1 HGNC:20597 ubiquitin-fold modifier 1 P61960 Nucleus. Cytoplasm. Note=Predominantly nuclear. Also expressed diffusely in the cytoplasm. secreted 24 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UFSP1 HGNC:33821 UFM1-specific peptidase 1 (non-functional) Q6NVU6 secreted 30 0 secreted secreted Eutheria Bilateria Eukaryota UFSP2 HGNC:25640 UFM1-specific peptidase 2 Q9NUQ7 Cytoplasm (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity). nucleus 35 0 nucleus nucleus Eutheria Bilateria Eukaryota UGCG HGNC:12524 UDP-glucose ceramide glucosyltransferase Q16739 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 12873973,10945987,12873973 golgi apparatus membrane 96 4 endoplasmic reticulum. golgi apparatus multiple Bilateria Cell.Organisms Cell.Organisms UGDH HGNC:12525 UDP-glucose 6-dehydrogenase O60701 cytoplasm 50 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms UGGT1 HGNC:15663 UDP-glucose glycoprotein glucosyltransferase 1 Q9NYU2 Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10694380,15598749 endoplasmic reticulum 32 0 endoplasmic reticulum. mitochondrion multiple Eukaryota Eukaryota Eukaryota UGGT2 HGNC:15664 UDP-glucose glycoprotein glucosyltransferase 2 Q9NYU1 Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum (GO:0005783); Mitochondrion (GO:0005739) 10694380,12913004,15598749 endoplasmic reticulum 28 0 endoplasmic reticulum. mitochondrion multiple Eukaryota Eukaryota Eukaryota UGP2 HGNC:12527 UDP-glucose pyrophosphorylase 2 Q16851 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms UGT2A1 HGNC:12542 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus Q9Y4X1 Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 10748067,11179432,11376859 cytoplasm 28 1 endoplasmic reticulum. nucleus multiple Bilateria Bilateria NA UGT2A3 HGNC:28528 UDP glucuronosyltransferase 2 family, polypeptide A3 Q6UWM9 Membrane; Single-pass type I membrane protein (Potential). cytoplasm 26 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms UGT2B10 HGNC:12544 UDP glucuronosyltransferase 2 family, polypeptide B10 P36537 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) cytoplasm 24 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms UGT2B11 HGNC:12545 UDP glucuronosyltransferase 2 family, polypeptide B11 O75310 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 9675083 cytoplasm 24 1 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms UGT2B15 HGNC:12546 UDP glucuronosyltransferase 2 family, polypeptide B15 P54855 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 9202245 cytoplasm 27 1 endoplasmic reticulum endoplasmic reticulum NA NA Cell.Organisms UGT2B17 HGNC:12547 UDP glucuronosyltransferase 2 family, polypeptide B17 O75795 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 8798464 cytoplasm 27 1 endoplasmic reticulum endoplasmic reticulum Bilateria Bilateria Cell.Organisms UGT2B28 HGNC:13479 UDP glucuronosyltransferase 2 family, polypeptide B28 Q9BY64 Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11300766 cytoplasm 22 1 endoplasmic reticulum. endoplasmic reticulum membrane multiple Bilateria Bilateria Cell.Organisms UGT2B4 HGNC:12553 UDP glucuronosyltransferase 2 family, polypeptide B4 P06133 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 9271674,9271674 cytoplasm 27 1 endoplasmic reticulum. nucleus multiple Bilateria Bilateria Cell.Organisms UGT2B7 HGNC:12554 UDP glucuronosyltransferase 2 family, polypeptide B7 P16662 Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 11883901,11883901 cytoplasm 27 1 endoplasmic reticulum. nucleus multiple Bilateria Bilateria Cell.Organisms UGT3A1 HGNC:26625 UDP glycosyltransferase 3 family, polypeptide A1 Q6NUS8 Membrane; Single-pass type I membrane protein (Potential). cytoplasm 23 1 cytoplasm cytoplasm Eutheria Bilateria Cell.Organisms UGT3A2 HGNC:27266 UDP glycosyltransferase 3 family, polypeptide A2 Q3SY77 Membrane; Single-pass type I membrane protein (Potential). cytoplasm 25 1 cytoplasm cytoplasm Eutheria Bilateria Cell.Organisms UGT8 HGNC:12555 UDP glycosyltransferase 8 Q16880 Membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 8661025,12925779,9748263,9748263 cytoplasm 20 1 endoplasmic reticulum. nucleus multiple Euteleostomi Bilateria Cell.Organisms UHMK1 HGNC:19683 U2AF homology motif (UHM) kinase 1 Q8TAS1 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12782393,12782393 nucleus 100 0 cytoplasm. nucleus multiple Theria Euteleostomi Cell.Organisms UHRF1 HGNC:12556 ubiquitin-like with PHD and ring finger domains 1 Q96T88 Nucleus. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions. Nucleus (GO:0005634); Mitochondrion (GO:0005739) 10646863,15598749 nucleus 100 0 mitochondrion. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms UHRF1BP1 HGNC:21216 UHRF1 binding protein 1 Q6BDS2 nucleus 80 0 nucleus nucleus Bilateria Eukaryota Eukaryota UHRF1BP1L HGNC:29102 UHRF1 binding protein 1-like A0JNW5 Nucleus (GO:0005634) 17081983 nucleus 85 0 nucleus nucleus Bilateria Eukaryota Eukaryota UHRF2 HGNC:12557 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase Q96PU4 Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity). Nucleus (GO:0005634) 12176013 nucleus 100 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms UIMC1 HGNC:30298 ubiquitin interaction motif containing 1 Q96RL1 Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Nucleus (GO:0005634) 12080054 nucleus 100 0 nucleus nucleus Amniota Amniota Craniata ULBP1 HGNC:14893 UL16 binding protein 1 Q9BZM6 Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts. Plasma membrane (GO:0005886) 11239445 plasma membrane 53 1 endoplasmic reticulum. plasma membrane multiple Eutheria Eutheria Craniata ULBP2 HGNC:14894 UL16 binding protein 2 Q9BZM5 Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Extracellular (GO:0005576); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 11444831,11444831,12847260,11777960,12847260 plasma membrane 87 1 endoplasmic reticulum. plasma membrane. secreted multiple Eutheria Eutheria Craniata ULBP3 HGNC:14895 UL16 binding protein 3 Q9BZM4 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886) 15051759 plasma membrane 46 1 plasma membrane plasma membrane Eutheria Eutheria Craniata ULK1 HGNC:12558 unc-51 like autophagy activating kinase 1 O75385 Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome (By similarity). Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 11146101,11146101,17081983 cytoplasm 24 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Bilateria Bilateria Cell.Organisms ULK2 HGNC:13480 unc-51 like autophagy activating kinase 2 Q8IYT8 Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane. Cytoplasm (GO:0005737) 15014045 cytoplasm 26 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms ULK3 HGNC:19703 unc-51 like kinase 3 Q6PHR2 Cytoplasm. Note=Localizes to pre- autophagosomal structure during cellular senescence. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms ULK4 HGNC:15784 unc-51 like kinase 4 Q96C45 cytoplasm 15 3 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms UMOD HGNC:12559 uromodulin P07911 Apical cell membrane; Lipid-anchor, GPI- anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Uromodulin, secreted form: Secreted. Plasma membrane (GO:0005886) 2249987 secreted 36 1 plasma membrane. secreted multiple Chordata Chordata Cell.Organisms UMODL1 HGNC:12560 uromodulin-like 1 Q5DID0 Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Plasma membrane (GO:0005886);Cytoplasm (GO:0005737) 15194491/15194491 plasma membrane 54 1 cytoplasm. plasma membrane multiple Euteleostomi Euteleostomi Eumetazoa UMPS HGNC:12563 uridine monophosphate synthetase P11172 Nucleus (GO:0005634) 8069469 cytoplasm 68 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms UNC119 HGNC:12565 unc-119 homolog (C. elegans) Q13432 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9538874,14757743,9538874 cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota UNC119B HGNC:16488 unc-119 homolog B (C. elegans) A6NIH7 Cell projection, cilium. Note=Enriched at the transition zone and extended into the proximal end of the cilium. cytoplasm 66 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota UNC13A HGNC:23150 unc-13 homolog A (C. elegans) Q9UPW8 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity). Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity). Cytosol (GO:0005829); Plasma membrane (GO:0005886) 12871971,12871971 cytoplasm 28 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota UNC13B HGNC:12566 unc-13 homolog B (C. elegans) O14795 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity). Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Golgi apparatus (GO:0005794) 9607201,12871971,10233166,12871971,10233166 cytoplasm 28 0 cytoplasm. golgi apparatus multiple Bilateria Bilateria Eukaryota UNC13C HGNC:23149 unc-13 homolog C (C. elegans) Q8NB66 Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity). Note=Localized to presynaptic structures (By similarity). cytoplasm 31 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota UNC13D HGNC:23147 unc-13 homolog D (C. elegans) Q70J99 Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 14622600,14699162,14699162,14622600,17081983 cytoplasm 23 0 cytoplasm. endosome. lysosome multiple Theria Amniota Opisthokonta UNC45A HGNC:30594 unc-45 homolog A (C. elegans) Q9H3U1 Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region. Little protein in the nucleus. Nucleus (GO:0005634) 17081983 cytoplasm 46 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms UNC45B HGNC:14304 unc-45 homolog B (C. elegans) Q8IWX7 Cytoplasm, cytosol (By similarity). cytoplasm 94 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota UNC50 HGNC:16046 unc-50 homolog (C. elegans) Q53HI1 Nucleus inner membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 10980252 golgi apparatus membrane 36 7 golgi apparatus membrane. nucleus multiple Eukaryota Eukaryota Eukaryota UNC5A HGNC:12567 unc-5 homolog A (C. elegans) Q6ZN44 Cell membrane; Single-pass type I membrane protein (By similarity). Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones (By similarity). Plasma membrane (GO:0005886) 12598531 plasma membrane 94 1 plasma membrane plasma membrane Chordata Bilateria Eukaryota UNC5B HGNC:12568 unc-5 homolog B (C. elegans) Q8IZJ1 Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft. Plasma membrane (GO:0005886) plasma membrane 45 1 plasma membrane plasma membrane Chordata Bilateria Eukaryota UNC5C HGNC:12569 unc-5 homolog C (C. elegans) O95185 Membrane; Single-pass type I membrane protein (By similarity). Plasma membrane (GO:0005886) 9782087 plasma membrane 47 1 plasma membrane plasma membrane Chordata Bilateria Eukaryota UNC5CL HGNC:21203 unc-5 homolog C (C. elegans)-like Q8IV45 Membrane; Single-pass type III membrane protein (Potential). Cytoplasm. Cytoplasm (GO:0005737) 14769797 plasma membrane 10 0 cytoplasm cytoplasm Theria Deuterostomia Eumetazoa UNC5D HGNC:18634 unc-5 homolog D (C. elegans) Q6UXZ4 Membrane; Single-pass type I membrane protein (By similarity). plasma membrane 35 1 plasma membrane plasma membrane Chordata Bilateria Metazoa UNC79 HGNC:19966 unc-79 homolog (C. elegans) Q9P2D8 Membrane; Multi-pass membrane protein (Potential). nucleus 31 2 nucleus nucleus Bilateria Bilateria Metazoa UNC80 HGNC:26582 unc-80 homolog (C. elegans) Q8N2C7 Membrane; Multi-pass membrane protein (Potential). nucleus 66 9 nucleus nucleus Bilateria Bilateria Opisthokonta UNC93A HGNC:12570 unc-93 homolog A (C. elegans) Q86WB7 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) 12381271 plasma membrane 100 11 plasma membrane plasma membrane Bilateria Eukaryota Eukaryota UNC93B1 HGNC:13481 unc-93 homolog B1 (C. elegans) Q9H1C4 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. Integral to membrane (GO:0016021) plasma membrane 10 12 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota UNCX HGNC:33194 UNC homeobox A6NJT0 Nucleus (By similarity). nucleus 31 0 nucleus nucleus Euteleostomi Bilateria Eukaryota UNG HGNC:12572 uracil-DNA glycosylase P13051 Isoform 1: Mitochondrion. Isoform 2: Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Mitochondrion (GO:0005739); Nucleolus (GO:0005730) 17081983,17081983/9016624,9753728,7556436,7556436,9016624,9753728,7556436 nucleus 7 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Cell.Organisms Cell.Organisms UNK HGNC:29369 unkempt family zinc finger Q9C0B0 cytoplasm 58 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota UNKL HGNC:14184 unkempt family zinc finger-like Q9H9P5 Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm. Nucleus (GO:0005634) cytoplasm 64 0 cytoplasm. nucleus multiple Mammalia Mammalia Eukaryota UPB1 HGNC:16297 ureidopropionase, beta Q9UBR1 Cytoplasm. Cytoplasm (GO:0005737) 3931905 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms UPF1 HGNC:9962 UPF1 regulator of nonsense transcripts homolog (yeast) Q92900 Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 17081983/9064659,11113196,12417715,12723973,16364915,12228722 cytoplasm 54 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms UPF2 HGNC:17854 UPF2 regulator of nonsense transcripts homolog (yeast) Q9HAU5 Cytoplasm, perinuclear region. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11163187,11073994,12723973,12554878,11113196,11073994 cytoplasm 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota UPF3A HGNC:20332 UPF3 regulator of nonsense transcripts homolog A (yeast) Q9H1J1 Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11163187,11163187,11113196 secreted 27 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota UPF3B HGNC:20439 UPF3 regulator of nonsense transcripts homolog B (yeast) Q9BZI7 Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11163187,11113196,11163187,11113196,15635413 nucleus 16 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota UPK1A HGNC:12577 uroplakin 1A O00322 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12036448,12475947 golgi apparatus membrane 64 4 endoplasmic reticulum. plasma membrane multiple Theria Euteleostomi Opisthokonta UPK1B HGNC:12578 uroplakin 1B O75841 Membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12475947,12475947 golgi apparatus membrane 64 4 endoplasmic reticulum. plasma membrane multiple Tetrapoda Tetrapoda Metazoa UPK2 HGNC:12579 uroplakin 2 O00526 Cell membrane; Single-pass type I membrane protein (Potential). Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER) (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 9515818,8175808,12475947 plasma membrane 28 1 endoplasmic reticulum. plasma membrane multiple Theria Theria Euteleostomi UPK3A HGNC:12580 uroplakin 3A O75631 Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER) (By similarity). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783) 12475947,12475947 endoplasmic reticulum membrane 82 1 endoplasmic reticulum. plasma membrane multiple Tetrapoda Tetrapoda Craniata UPK3B HGNC:21444 uroplakin 3B Q9BT76 Cell membrane; Single-pass type I membrane protein (Potential). Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 12446744,12446744 secreted 87 0 endoplasmic reticulum endoplasmic reticulum NA NA Craniata UPK3BL HGNC:37278 uroplakin 3B-like B0FP48 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 51 1 plasma membrane plasma membrane NA NA NA UPP1 HGNC:12576 uridine phosphorylase 1 Q16831 Cytoplasm (GO:0005737) 11278417,12084455 cytoplasm 51 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms UPP2 HGNC:23061 uridine phosphorylase 2 O95045 Cytoplasm (GO:0005737) 11278417 cytoplasm 35 1 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms UPRT HGNC:28334 uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) Q96BW1 Cytoplasm. Nucleus. cytoplasm 19 0 cytoplasm. nucleus multiple Opisthokonta Opisthokonta Cell.Organisms UQCC1 HGNC:15891 ubiquinol-cytochrome c reductase complex assembly factor 1 Q9NVA1 Cytoplasmic vesicle (By similarity). Note=Cytoplasmic vesicular structures (By similarity). Cytoplasmic vesicle (GO:0016023) 11118897 mitochondrion 21 1 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms UQCC2 HGNC:21237 ubiquinol-cytochrome c reductase complex assembly factor 2 Q9BRT2 Mitochondrion matrix, mitochondrion nucleoid. mitochondrion 100 0 mitochondrion mitochondrion Tetrapoda Deuterostomia Holozoa UQCR10 HGNC:30863 ubiquinol-cytochrome c reductase, complex III subunit X Q9UDW1 Mitochondrion inner membrane (By similarity). Mitochondrial membrane (GO:0005740) 8592474 mitochondrion membrane 36 1 mitochondrion membrane mitochondrion membrane Eutheria Eukaryota Opisthokonta UQCR11 HGNC:30862 ubiquinol-cytochrome c reductase, complex III subunit XI O14957 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 9161705 mitochondrion membrane 63 1 mitochondrion mitochondrion Amniota Amniota Bilateria UQCRB HGNC:12582 ubiquinol-cytochrome c reductase binding protein P14927 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 8751380 mitochondrion 30 0 mitochondrion mitochondrion Opisthokonta Eukaryota Eukaryota UQCRC1 HGNC:12585 ubiquinol-cytochrome c reductase core protein I P31930 Mitochondrion inner membrane. Mitochondrion (GO:0005739); Nucleus (GO:0005634) 8407948,12067236,1846623,12067236 mitochondrion 46 0 mitochondrion. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms UQCRC2 HGNC:12586 ubiquinol-cytochrome c reductase core protein II P22695 Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Mitochondrion (GO:0005739) 12067236,2547763,2162168,15033988,15598749 mitochondrion 9 0 mitochondrion mitochondrion Bilateria Eukaryota Cell.Organisms UQCRFS1 HGNC:12587 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 P47985 Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion (GO:0005739) 8088805,12821338,15033988,15598749 mitochondrion membrane 100 0 mitochondrion. mitochondrion membrane multiple Eukaryota Cell.Organisms Cell.Organisms UQCRH HGNC:12590 ubiquinol-cytochrome c reductase hinge protein P07919 Mitochondrion inner membrane. Mitochondrion (GO:0005739) 2826252,12881716,15544925,9473493 nucleus 45 0 mitochondrion mitochondrion Bilateria Opisthokonta Eukaryota UQCRQ HGNC:29594 ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa O14949 Mitochondrion inner membrane. mitochondrion membrane 8 1 mitochondrion membrane mitochondrion membrane Bilateria Bilateria Eukaryota URB1 HGNC:17344 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) O60287 Nucleus, nucleolus. nucleus 100 2 nucleus nucleus Chordata Bilateria Eukaryota URB2 HGNC:28967 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) Q14146 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 15265697,17081983,15635413,11790298 nucleus 100 3 nucleus nucleus Euteleostomi Deuterostomia Holozoa URGCP HGNC:30890 upregulator of cell proliferation Q8TCY9 Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei. Cytoplasm (GO:0005737) 12082552 nucleus 65 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms URI1 HGNC:13236 URI1, prefoldin-like chaperone O94763 Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite (By similarity). Note=Colocalizes with PFDN2, PFDN4, PPP1, RPS6KB1 and STAP1 at mitochondrion. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Microsome (GO:0005792); Nucleus (GO:0005634);Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9878255,17081983,9878255,9878255,9878255/15367675,15367675 nucleus 64 0 cytoplasm. endoplasmic reticulum. mitochondrion. nucleus multiple Euteleostomi Eukaryota Eukaryota URM1 HGNC:28378 ubiquitin related modifier 1 Q9BTM9 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Amniota Eukaryota Eukaryota UROC1 HGNC:26444 urocanate hydratase 1 Q96N76 cytoplasm 65 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms Cell.Organisms UROD HGNC:12591 uroporphyrinogen decarboxylase P06132 Cytoplasm. Cytoplasm (GO:0005737) 2243121 cytoplasm 100 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms Cell.Organisms UROS HGNC:12592 uroporphyrinogen III synthase P10746 Cytoplasm (GO:0005737) 3792391 mitochondrion 34 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms USB1 HGNC:25792 U6 snRNA biogenesis 1 Q9BQ65 Nucleus. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota USE1 HGNC:30882 unconventional SNARE in the ER 1 homolog (S. cerevisiae) Q9NZ43 Endoplasmic reticulum membrane; Single-pass type IV membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Bilateria Eukaryota USF1 HGNC:12593 upstream transcription factor 1 P22415 Nucleus. Nucleus (GO:0005634) 12917334,12684442 nucleus 100 0 nucleus nucleus Theria Euteleostomi Opisthokonta USF2 HGNC:12594 upstream transcription factor 2, c-fos interacting Q15853 Nucleus. Nucleus (GO:0005634) 11058604,9099698,19059367 nucleus 100 0 nucleus nucleus Theria Deuterostomia Eukaryota USH1C HGNC:12597 Usher syndrome 1C (autosomal recessive, severe) Q9Y6N9 Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin (By similarity). Detected at the tip of cochlear hair cell stereocilia. Cytoplasm (GO:0005737) 10209257 cytoplasm 100 0 cytoplasm cytoplasm Amniota Bilateria Holozoa USH1G HGNC:16356 Usher syndrome 1G (autosomal recessive) Q495M9 Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein (By similarity). Note=Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (By similarity). Cytoplasm (GO:0005737) 12588794 nucleus 16 0 cytoplasm cytoplasm Euteleostomi Bilateria Cell.Organisms USH2A HGNC:12601 Usher syndrome 2A (autosomal recessive, mild) O75445 Cell projection, stereocilium membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Extracellular (GO:0005576) 9624053 secreted 21 2 secreted secreted Deuterostomia Deuterostomia Cell.Organisms USHBP1 HGNC:24058 Usher syndrome 1C binding protein 1 Q8N6Y0 cytoplasm 98 0 cytoplasm cytoplasm Mammalia Mammalia Eumetazoa USMG5 HGNC:30889 up-regulated during skeletal muscle growth 5 homolog (mouse) Q96IX5 Mitochondrion membrane; Single-pass membrane protein (By similarity). Integral to membrane (GO:0016021) mitochondrion membrane 94 1 mitochondrion membrane mitochondrion membrane Amniota Bilateria Bilateria USO1 HGNC:30904 USO1 vesicle transport factor O60763 Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Note=Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 1512287,9478999,9478999,12438416,12438416,15561729 golgi apparatus 17 3 cytoplasm. golgi apparatus. nucleus multiple Opisthokonta Eukaryota Eukaryota USP1 HGNC:12607 ubiquitin specific peptidase 1 O94782 Nucleus. Nucleus (GO:0005634) 15694335 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota USP10 HGNC:12608 ubiquitin specific peptidase 10 Q14694 Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 15 0 cytoplasm. endosome. nucleus multiple Human Eukaryota Eukaryota USP11 HGNC:12609 ubiquitin specific peptidase 11 P51784 Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin. Nucleus (GO:0005634) 12084015 endoplasmic reticulum membrane 26 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota USP12 HGNC:20485 ubiquitin specific peptidase 12 O75317 Nucleus (GO:0005634) 9615226 nucleus 51 0 nucleus nucleus Eukaryota Eukaryota Eukaryota USP13 HGNC:12611 ubiquitin specific peptidase 13 (isopeptidase T-3) Q92995 cytoplasm 29 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota USP14 HGNC:12612 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) P54578 Cytoplasm. Cell membrane; Peripheral membrane protein. Cytosol (GO:0005829) 15561729 nucleus 28 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota USP15 HGNC:12613 ubiquitin specific peptidase 15 Q9Y4E8 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 15494318,15494318 endoplasmic reticulum membrane 24 0 cytoplasm. nucleus multiple Chordata Eukaryota Cell.Organisms USP16 HGNC:12614 ubiquitin specific peptidase 16 Q9Y5T5 Nucleus (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 10077596,10077596 cytoplasm 15 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota USP17L10 HGNC:44438 ubiquitin specific peptidase 17-like family member 10 C9JJH3 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 38 0 nucleus nucleus NA NA Eukaryota USP17L11 HGNC:44439 ubiquitin specific peptidase 17-like family member 11 C9JVI0 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 41 0 nucleus nucleus NA NA Eukaryota USP17L12 HGNC:44440 ubiquitin specific peptidase 17-like family member 12 C9JPN9 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 44 0 nucleus nucleus NA NA Eukaryota USP17L13 HGNC:44441 ubiquitin specific peptidase 17-like family member 13 C9JLJ4 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 41 0 nucleus nucleus NA NA Eukaryota USP17L15 HGNC:44443 ubiquitin specific peptidase 17-like family member 15 C9J2P7 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 39 0 nucleus nucleus NA NA Eukaryota USP17L17 HGNC:44445 ubiquitin specific peptidase 17-like family member 17 D6RBQ6 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 39 0 nucleus nucleus NA NA Eukaryota USP17L18 HGNC:44446 ubiquitin specific peptidase 17-like family member 18 D6R9N7 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 41 0 nucleus nucleus NA NA Eukaryota USP17L19 HGNC:44447 ubiquitin specific peptidase 17-like family member 19 D6RCP7 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 41 0 nucleus nucleus NA NA Eukaryota USP17L2 HGNC:34434 ubiquitin specific peptidase 17-like family member 2 Q6R6M4 Nucleus. Endoplasmic reticulum. nucleus 39 0 endoplasmic reticulum. nucleus multiple NA NA Eukaryota USP17L20 HGNC:44448 ubiquitin specific peptidase 17-like family member 20 D6RJB6 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 41 0 nucleus nucleus NA NA Eukaryota USP17L21 HGNC:44449 ubiquitin specific peptidase 17-like family member 21 D6R901 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 44 0 nucleus nucleus NA NA Eukaryota USP17L22 HGNC:44450 ubiquitin specific peptidase 17-like family member 22 D6RA61 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 39 0 nucleus nucleus NA NA Eukaryota USP17L23 HGNC:44451 ubiquitin specific peptidase 17-like family member 23 D6RBM5 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 45 0 nucleus nucleus NA NA Eukaryota USP17L24 HGNC:44453 ubiquitin specific peptidase 17-like family member 24 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 42 0 nucleus nucleus NA NA Eukaryota USP17L25 HGNC:44452 ubiquitin specific peptidase 17-like family member 25 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 41 0 nucleus nucleus NA NA Eukaryota USP17L26 HGNC:44454 ubiquitin specific peptidase 17-like family member 26 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 43 0 nucleus nucleus NA NA Eukaryota USP17L27 HGNC:44455 ubiquitin specific peptidase 17-like family member 27 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 44 0 nucleus nucleus NA NA Eukaryota USP17L28 HGNC:44456 ubiquitin specific peptidase 17-like family member 28 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 45 0 nucleus nucleus NA NA Eukaryota USP17L29 HGNC:44457 ubiquitin specific peptidase 17-like family member 29 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 46 0 nucleus nucleus NA NA Eukaryota USP17L30 HGNC:44458 ubiquitin specific peptidase 17-like family member 30 Q0WX57 Nucleus, nucleolus. Endoplasmic reticulum (By similarity). nucleus 47 0 nucleus nucleus NA NA Eukaryota USP17L5 HGNC:37177 ubiquitin specific peptidase 17-like family member 5 A8MUK1 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 38 0 nucleus nucleus NA NA Eukaryota USP17L7 HGNC:37180 ubiquitin specific peptidase 17-like family member 7 P0C7H9 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 35 0 nucleus nucleus NA NA NA USP17L8 HGNC:37181 ubiquitin specific peptidase 17-like family member 8 P0C7I0 Nucleus (By similarity). Endoplasmic reticulum (By similarity). nucleus 38 0 nucleus nucleus NA NA NA USP18 HGNC:12616 ubiquitin specific peptidase 18 Q9UMW8 Nucleus (GO:0005634) 10777664 endoplasmic reticulum membrane 15 0 nucleus nucleus Amniota Euteleostomi Eukaryota USP19 HGNC:12617 ubiquitin specific peptidase 19 O94966 Endoplasmic reticulum membrane; Single-pass membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Chordata Eukaryota Eukaryota USP2 HGNC:12618 ubiquitin specific peptidase 2 O75604 Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Isoform 4: Nucleus (By similarity). nucleus 25 0 nucleus nucleus Chordata Eukaryota Eukaryota USP20 HGNC:12619 ubiquitin specific peptidase 20 Q9Y2K6 Cytoplasm, perinuclear region (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear. Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634) 12865408,17081983 nucleus 18 0 cytoplasm. endoplasmic reticulum. nucleus multiple Deuterostomia Eukaryota Eukaryota USP21 HGNC:12620 ubiquitin specific peptidase 21 Q9UK80 Cytoplasm. Nucleus. endoplasmic reticulum membrane 25 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota USP22 HGNC:12621 ubiquitin specific peptidase 22 Q9UPT9 Nucleus (Probable). nucleus 22 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms USP24 HGNC:12623 ubiquitin specific peptidase 24 Q9UPU5 Cytoplasm (GO:0005737) cytoplasm 19 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota USP25 HGNC:12624 ubiquitin specific peptidase 25 Q9UHP3 Cytoplasm. Isoform USP25m: Cytoplasm (By similarity). Nucleus (By similarity). Note=Some transient punctuate nuclear location in myotubes during myocyte development (By similarity). Cytoplasm (GO:0005737) 10644437 nucleus 41 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota USP26 HGNC:13485 ubiquitin specific peptidase 26 Q9BXU7 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota USP27X HGNC:13486 ubiquitin specific peptidase 27, X-linked A6NNY8 nucleus 20 0 nucleus nucleus NA NA NA USP28 HGNC:12625 ubiquitin specific peptidase 28 Q96RU2 Nucleus, nucleoplasm. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota USP29 HGNC:18563 ubiquitin specific peptidase 29 Q9HBJ7 nucleus 35 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota USP3 HGNC:12626 ubiquitin specific peptidase 3 Q9Y6I4 Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin. nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota USP30 HGNC:20065 ubiquitin specific peptidase 30 Q70CQ3 Mitochondrion outer membrane. Integral to membrane (GO:0016021) nucleus 15 2 nucleus nucleus Bilateria Eukaryota Eukaryota USP31 HGNC:20060 ubiquitin specific peptidase 31 Q70CQ4 nucleus 21 0 nucleus nucleus Chordata Eukaryota Eukaryota USP32 HGNC:19143 ubiquitin specific peptidase 32 Q8NFA0 Membrane; Lipid-anchor (Potential). Golgi apparatus. Cytoplasm (GO:0005737) 17081983 endoplasmic reticulum membrane 30 0 cytoplasm. golgi apparatus multiple Bilateria Eukaryota Eukaryota USP33 HGNC:20059 ubiquitin specific peptidase 33 Q8TEY7 Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Isoform 3: Golgi apparatus. Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783) 11739384,12865408 nucleus 31 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Deuterostomia Eukaryota Cell.Organisms USP34 HGNC:20066 ubiquitin specific peptidase 34 Q70CQ2 nucleus 15 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota USP35 HGNC:20061 ubiquitin specific peptidase 35 Q9P2H5 nucleus 19 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota USP36 HGNC:20062 ubiquitin specific peptidase 36 Q9P275 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota USP37 HGNC:20063 ubiquitin specific peptidase 37 Q86T82 Cytoplasm (GO:0005737) 17081983 nucleus 32 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota USP38 HGNC:20067 ubiquitin specific peptidase 38 Q8NB14 nucleus 24 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota USP39 HGNC:20071 ubiquitin specific peptidase 39 Q53GS9 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10022888,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota USP4 HGNC:12627 ubiquitin specific peptidase 4 (proto-oncogene) Q13107 Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type (By similarity). Cytoplasm (GO:0005737);Nucleus (GO:0005634) 9464533/8183569 endoplasmic reticulum membrane 27 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota USP40 HGNC:20069 ubiquitin specific peptidase 40 Q9NVE5 cytoplasm 22 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota USP41 HGNC:20070 ubiquitin specific peptidase 41 Q3LFD5 endoplasmic reticulum membrane 15 0 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Eukaryota USP42 HGNC:20068 ubiquitin specific peptidase 42 Q9H9J4 nucleus 27 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota USP43 HGNC:20072 ubiquitin specific peptidase 43 Q70EL4 nucleus 20 0 nucleus nucleus Chordata Eukaryota Eukaryota USP44 HGNC:20064 ubiquitin specific peptidase 44 Q9H0E7 Nucleus. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis (By similarity). nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms USP45 HGNC:20080 ubiquitin specific peptidase 45 Q70EL2 nucleus 21 0 nucleus nucleus Tetrapoda Opisthokonta Eukaryota USP46 HGNC:20075 ubiquitin specific peptidase 46 P62068 nucleus 51 0 nucleus nucleus Eukaryota Eukaryota Eukaryota USP47 HGNC:20076 ubiquitin specific peptidase 47 Q96K76 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota USP48 HGNC:18533 ubiquitin specific peptidase 48 Q86UV5 Cytoplasm. Nucleus. Nucleus (GO:0005634) 9409543 nucleus 18 1 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota USP49 HGNC:20078 ubiquitin specific peptidase 49 Q70CQ1 nucleus 53 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms USP5 HGNC:12628 ubiquitin specific peptidase 5 (isopeptidase T) P45974 Extracellular (GO:0005576) 14718574 cytoplasm 38 0 secreted secreted Eukaryota Eukaryota NA USP50 HGNC:20079 ubiquitin specific peptidase 50 Q70EL3 nucleus 18 0 nucleus nucleus Mammalia Euteleostomi Eukaryota USP51 HGNC:23086 ubiquitin specific peptidase 51 Q70EK9 endoplasmic reticulum membrane 20 0 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Cell.Organisms USP53 HGNC:29255 ubiquitin specific peptidase 53 Q70EK8 nucleus 80 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota USP54 HGNC:23513 ubiquitin specific peptidase 54 Q70EL1 cytoplasm 6 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota USP6 HGNC:12629 ubiquitin specific peptidase 6 (Tre-2 oncogene) P35125 Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton. Nucleus (GO:0005634); Plasma membrane (GO:0005886) ,16555005 endoplasmic reticulum membrane 26 0 cytoplasm. endosome. nucleus multiple Bilateria Eukaryota Eukaryota USP6NL HGNC:16858 USP6 N-terminal like Q92738 Golgi apparatus. Cytoplasmic vesicle. Cytoplasm (GO:0005737) 12399475 cytoplasm 13 0 cytoplasm. golgi apparatus multiple Opisthokonta Eukaryota Eukaryota USP7 HGNC:12630 ubiquitin specific peptidase 7 (herpes virus-associated) Q93009 Nucleus. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies. Nucleus (GO:0005634); Cytosol (GO:0005829) 12093161,16845383,15561729 nucleus 22 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms USP8 HGNC:12631 ubiquitin specific peptidase 8 P40818 Cytoplasm. Nucleus (By similarity). Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus (GO:0005634) 17081983 nucleus 24 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Eukaryota USP9X HGNC:12632 ubiquitin specific peptidase 9, X-linked Q93008 Cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/,12617843,19135894, cytoplasm 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota USP9Y HGNC:12633 ubiquitin specific peptidase 9, Y-linked O00507 Cytoplasm (By similarity). cytoplasm 90 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota USPL1 HGNC:20294 ubiquitin specific peptidase like 1 Q5W0Q7 Nucleus, Cajal body. nucleus 100 0 nucleus nucleus Chordata Chordata Eumetazoa UST HGNC:17223 uronyl-2-sulfotransferase Q9Y2C2 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). golgi apparatus membrane 19 1 golgi apparatus membrane golgi apparatus membrane Deuterostomia Deuterostomia Holozoa UTF1 HGNC:12634 undifferentiated embryonic cell transcription factor 1 Q5T230 Nucleus (Probable). Nucleus (GO:0005634) 9748258 secreted 17 0 nucleus nucleus Euarchontoglires Eutheria Eutheria UTP11L HGNC:24329 UTP11-like, U3 small nucleolar ribonucleoprotein (yeast) Q9Y3A2 Nucleus, nucleolus (By similarity). Nucleolus (GO:0005730); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Extracellular (GO:0005576) 11860508,15635413,11790298,11860508,11860508,11860508 nucleus 98 0 cytoplasm. nucleus. secreted multiple Eukaryota Eukaryota Eukaryota UTP14A HGNC:10665 UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) Q9BVJ6 Nucleus, nucleolus. Ribosome (GO:0005840) 15561729 nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota UTP14C HGNC:20321 UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) Q5TAP6 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) nucleus 86 0 nucleus nucleus NA NA Eukaryota UTP15 HGNC:25758 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) Q8TED0 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms UTP18 HGNC:24274 UTP18 small subunit (SSU) processome component homolog (yeast) Q9Y5J1 Nucleus, nucleolus. Nucleolus (GO:0005730) 12429849,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms UTP20 HGNC:17897 UTP20, small subunit (SSU) processome component, homolog (yeast) O75691 Nucleus, nucleolus. Note=Colocalizes with NCL in the nucleolus. Nucleolus (GO:0005730) 15635413,11790298 nucleus 100 3 nucleus nucleus Opisthokonta Eukaryota Eukaryota UTP23 HGNC:28224 UTP23, small subunit (SSU) processome component, homolog (yeast) Q9BRU9 Nucleus, nucleolus (By similarity). nucleus 18 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota UTP3 HGNC:24477 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) Q9NQZ2 Nucleus (By similarity). Nucleolus (GO:0005730) 15635413,11790298 nucleus 84 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota UTP6 HGNC:18279 UTP6, small subunit (SSU) processome component, homolog (yeast) Q9NYH9 Nucleus, nucleolus. Nucleolus (GO:0005730) 15635413 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota UTRN HGNC:12635 utrophin P46939 Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Neuromuscular junction. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11796130,11377836,11377836,17081983 cytoplasm 20 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota UTS2 HGNC:12636 urotensin 2 O95399 Secreted. Plasma membrane (GO:0005886) 9279525 secreted 100 0 secreted secreted Amniota Amniota Amniota UTS2B HGNC:30894 urotensin 2B Q765I0 Secreted (By similarity). secreted 44 0 secreted secreted Euarchontoglires Amniota Tetrapoda UTS2R HGNC:4468 urotensin 2 receptor Q9UKP6 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 10499587 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Deuterostomia Eumetazoa UTY HGNC:12638 ubiquitously transcribed tetratricopeptide repeat containing, Y-linked O14607 Nucleus (Potential). nucleus 23 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms UVRAG HGNC:12640 UV radiation resistance associated Q9P2Y5 Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial. Cytoplasm (GO:0005737) 9169138 cytoplasm 17 1 cytoplasm. endosome. lysosome multiple Deuterostomia Eukaryota Eukaryota UVSSA HGNC:29304 UV-stimulated scaffold protein A Q2YD98 Chromosome. Note=Accumulates at UV DNA damage sites. nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota UXS1 HGNC:17729 UDP-glucuronate decarboxylase 1 Q8NBZ7 Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) 11877387 golgi apparatus membrane 98 0 golgi apparatus golgi apparatus Bilateria Cell.Organisms Cell.Organisms UXT HGNC:12641 ubiquitously-expressed, prefoldin-like chaperone Q9UBK9 Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Nucleus (GO:0005634); Cytosol (GO:0005829);Nucleus (GO:0005634) 12762840,12762840/11854421 cytoplasm 10 1 cytoplasm. nucleus multiple Eutheria Eukaryota Eukaryota VAC14 HGNC:25507 Vac14 homolog (S. cerevisiae) Q08AM6 Endosome membrane. Microsome membrane (By similarity). Note=Mainly associated with membranes of the late endocytic pathway. Microsome (GO:0005792); Centrosome (GO:0005813) 17161399,16767081 nucleus 51 2 nucleus nucleus Eukaryota Eukaryota Eukaryota VAMP1 HGNC:12642 vesicle-associated membrane protein 1 (synaptobrevin 1) P23763 Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein. Plasma membrane (GO:0005886); Mitochondrion (GO:0005739); Endosome (GO:0005768) 9658161,9658161,9658161 vacuole membrane 10 1 endosome. mitochondrion. mitochondrion membrane. plasma membrane multiple Bilateria Eukaryota Eukaryota VAMP2 HGNC:12643 vesicle-associated membrane protein 2 (synaptobrevin 2) P63027 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=Neuronal synaptic vesicles. Plasma membrane (GO:0005886); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Zymogen granule (GO:0042588) 11295657,12517971,12417022,9658161,16278343 vacuole membrane 11 1 endosome. golgi apparatus. plasma membrane multiple NA NA Eukaryota VAMP3 HGNC:12644 vesicle-associated membrane protein 3 Q15836 Membrane; Single-pass type IV membrane protein (Probable). Cell junction, synapse, synaptosome (By similarity). Plasma membrane (GO:0005886) 9885218 vacuole membrane 20 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Eukaryota VAMP4 HGNC:12645 vesicle-associated membrane protein 4 O75379 Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles. Golgi apparatus (GO:0005794); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endosome (GO:0005768) 9553086,12682051,10359608,17081983,17081983,,11839700, vacuole membrane 20 1 cytoplasm. endosome. golgi apparatus. golgi apparatus membrane. nucleus multiple Eukaryota Eukaryota Eukaryota VAMP5 HGNC:12646 vesicle-associated membrane protein 5 O95183 Cell membrane; Single-pass type IV membrane protein (Probable). Endomembrane system; Single-pass type IV membrane protein (Probable). Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (Probable). Note=Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity). Plasma membrane (GO:0005886) 12682051 plasma membrane 31 1 endomembrane system. golgi apparatus membrane. plasma membrane multiple Eutheria Euteleostomi Eukaryota VAMP7 HGNC:11486 vesicle-associated membrane protein 7 P51809 Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (By similarity). Late endosome membrane; Single- pass type IV membrane protein (By similarity). Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). Plasma membrane (GO:0005886); Cell surface (GO:0009986); Lysosome (GO:0005764) 9614185,18775314,18775314 vacuole membrane 24 1 lysosome. lysosome membrane. plasma membrane multiple Eukaryota Eukaryota Eukaryota VAMP8 HGNC:12647 vesicle-associated membrane protein 8 Q9BV40 Lysosome membrane; Single-pass type IV membrane protein (Probable). Late endosome membrane; Single-pass type IV membrane protein (Probable). Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). Plasma membrane (GO:0005886); Endosome (GO:0005768); Secretory granule (GO:0030141); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Zymogen granule (GO:0042588) 9614193,9614193,10820264,11029036,10601239,16278343 vacuole membrane 14 1 endoplasmic reticulum. endosome. endosome membrane. golgi apparatus. lysosome membrane. plasma membrane multiple Theria Bilateria Eukaryota VANGL1 HGNC:15512 VANGL planar cell polarity protein 1 Q8TAA9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) 15456783 plasma membrane 67 4 plasma membrane plasma membrane Chordata Bilateria Eumetazoa VANGL2 HGNC:15511 VANGL planar cell polarity protein 2 Q9ULK5 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 11431695 plasma membrane 88 4 plasma membrane plasma membrane Chordata Bilateria Eumetazoa VAPA HGNC:12648 VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa Q9P0L0 Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. Plasma membrane (GO:0005886); Endoplasmic reticulum membrane (GO:0005789); Golgi membrane (GO:0000139); Mitochondrion (GO:0005739) 10523508,10544080,10544080,10544080,15598749 endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane. golgi apparatus membrane. mitochondrion. plasma membrane multiple Eukaryota Eukaryota Eukaryota VAPB HGNC:12649 VAMP (vesicle-associated membrane protein)-associated protein B and C O95292 Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. Plasma membrane (GO:0005886); Membrane fraction (GO:0005624); Mitochondrion (GO:0005739) ,17215244,15598749 endoplasmic reticulum membrane 55 1 plasma membrane plasma membrane Chordata Eukaryota Eukaryota VARS HGNC:12651 valyl-tRNA synthetase P26640 cytoplasm 42 0 cytoplasm cytoplasm Cell.Organisms Cell.Organisms NA VARS2 HGNC:21642 valyl-tRNA synthetase 2, mitochondrial Q5ST30 Mitochondrion (Potential). Mitochondrion (GO:0005739) 15598749 cytoplasm 33 0 mitochondrion mitochondrion NA NA Cell.Organisms VASH1 HGNC:19964 vasohibin 1 Q7L8A9 Secreted. secreted 100 0 secreted secreted Chordata Eukaryota Eukaryota VASH2 HGNC:25723 vasohibin 2 Q86V25 secreted 48 0 secreted secreted Euteleostomi Deuterostomia Eukaryota VASN HGNC:18517 vasorin Q6EMK4 Membrane; Single-pass type I membrane protein (Probable). Secreted. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 15247411,16188874 secreted 23 1 plasma membrane. secreted multiple Chordata Chordata Cell.Organisms VASP HGNC:12652 vasodilator-stimulated phosphoprotein P50552 Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. Cytoplasm (GO:0005737); Focal adhesion (GO:0005925); Extracellular matrix (GO:0005578) 12397215,1319722,11313394,,18029348, cytoplasm 27 0 cytoplasm. secreted multiple Homininae Homininae Eukaryota VAT1 HGNC:16919 vesicle amine transport 1 Q99536 Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm and a small amount is associated with mitochondria (By similarity). Cytoplasmic vesicle (GO:0016023) 8938427 cytoplasm 17 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms VAT1L HGNC:29315 vesicle amine transport 1-like Q9HCJ6 cytoplasm 18 0 cytoplasm cytoplasm Euteleostomi Cell.Organisms Cell.Organisms VAV1 HGNC:12657 vav 1 guanine nucleotide exchange factor P15498 Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 9115846,9115846,10620604 cytoplasm 36 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota VAV2 HGNC:12658 vav 2 guanine nucleotide exchange factor P52735 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9115846,9115846 cytoplasm 36 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota VAV3 HGNC:12659 vav 3 guanine nucleotide exchange factor Q9UKW4 Cytoplasm (GO:0005737) 10523675 cytoplasm 42 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota VAX1 HGNC:12660 ventral anterior homeobox 1 Q5SQQ9 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Euteleostomi Bilateria Eukaryota VAX2 HGNC:12661 ventral anterior homeobox 2 Q9UIW0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Euteleostomi Euteleostomi NA VBP1 HGNC:12662 von Hippel-Lindau binding protein 1 P61758 Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8674032,8674032 nucleus 39 0 cytoplasm. nucleus multiple Eukaryota Eukaryota NA VCAM1 HGNC:12663 vascular cell adhesion molecule 1 P19320 Membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886); Extracellular (GO:0005576) 9603478,10944555 secreted 12 0 secreted secreted Euteleostomi Euteleostomi Metazoa VCAN HGNC:2464 versican P13611 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 7528742 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms VCL HGNC:12665 vinculin P18206 Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Co-localizes with LIMD1 in the focal adhesions. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 11358843,10908164,17081983,11358843,17081983 secreted 9 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota VCP HGNC:12666 valosin containing protein P55072 Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN. Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Nucleolus (GO:0005730); Perinuclear region (GO:0048471); Mitochondrion (GO:0005739) 11087817,11913976,15037256,16275660,10855792,16525503,15037256,15037256,15037256,15037256,16275660,15598749 cytoplasm 36 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms VCPIP1 HGNC:30897 valosin containing protein (p97)/p47 complex interacting protein 1 Q96JH7 Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Note=Associated with Golgi stacks and endoplasmic reticulum (By similarity). Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 12473691,12473691,12473691 nucleus 72 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Deuterostomia Deuterostomia Metazoa VCPKMT HGNC:20352 valosin containing protein lysine (K) methyltransferase Q9H867 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms VCX HGNC:12667 variable charge, X-linked Q9H320 Nucleus (GO:0005634) 10607842 cytoplasm 27 0 nucleus nucleus Homininae Homininae NA VCX2 HGNC:18158 variable charge, X-linked 2 Q9H322 Nucleus (GO:0005634) 10607842 secreted 46 0 nucleus nucleus Human Human NA VCX3A HGNC:18159 variable charge, X-linked 3A Q9NNX9 Nucleolus (GO:0005730) cytoplasm 29 0 cytoplasm cytoplasm Homininae Homininae NA VCX3B HGNC:31838 variable charge, X-linked 3B Q9H321 cytoplasm 24 0 cytoplasm cytoplasm Homininae Homininae NA VCY HGNC:12668 variable charge, Y-linked O14598 Nucleus (GO:0005634) 10607842 nucleus 71 0 nucleus nucleus Catarrhini Catarrhini NA VCY1B HGNC:31751 variable charge, Y-linked 1B O14598 Nucleus (GO:0005634) 10607842 nucleus 71 0 nucleus nucleus Catarrhini Catarrhini NA VDAC1 HGNC:12669 voltage-dependent anion channel 1 P21796 Mitochondrion outer membrane. Cell membrane. Mitochondrion (GO:0005739); Plasma membrane (GO:0005886); Endosome (GO:0005768); Nucleolus (GO:0005730); Zymogen granule (GO:0042588) 12767928,17510655,15598749,11091140,9644232,15635413,16278343 mitochondrion membrane 52 0 endosome. mitochondrion. nucleus multiple Euteleostomi Euteleostomi Eukaryota VDAC2 HGNC:12672 voltage-dependent anion channel 2 P45880 Mitochondrion outer membrane. Mitochondrion (GO:0005739); Nucleolus (GO:0005730); Zymogen granule (GO:0042588); Extracellular (GO:0005576); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12881569,15598749,15635413,16278343,14739283,17081983,17081983 mitochondrion membrane 49 0 cytoplasm. mitochondrion. nucleus. secreted multiple Opisthokonta Eukaryota Eukaryota VDAC3 HGNC:12674 voltage-dependent anion channel 3 Q9Y277 Mitochondrion outer membrane. Mitochondrion (GO:0005739) 11507092,9804816,15598749 mitochondrion membrane 44 0 mitochondrion mitochondrion Euteleostomi Opisthokonta Eukaryota VDR HGNC:12679 vitamin D (1,25- dihydroxyvitamin D3) receptor P11473 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 12145331,12145331,12847098,2835767 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa VEGFA HGNC:12680 vascular endothelial growth factor A P15692 Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. Extracellular (GO:0005576) 9202027 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eumetazoa VEGFB HGNC:12681 vascular endothelial growth factor B P49765 Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. Extracellular (GO:0005576) 8919691 secreted 100 0 secreted secreted Mammalia Mammalia Eumetazoa VEGFC HGNC:12682 vascular endothelial growth factor C P49767 Secreted. Extracellular (GO:0005576) 9233800 secreted 100 0 secreted secreted Chordata Chordata Metazoa VENTX HGNC:13639 VENT homeobox O95231 Nucleus (Probable). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Catarrhini Eukaryota Eukaryota VEPH1 HGNC:25735 ventricular zone expressed PH domain-containing 1 Q14D04 Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). nucleus 33 0 nucleus nucleus Bilateria Bilateria Holozoa VEZF1 HGNC:12949 vascular endothelial zinc finger 1 Q14119 Nucleus. Nucleus (GO:0005634) 11504723 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota VEZT HGNC:18258 vezatin, adherens junctions transmembrane protein Q9HBM0 Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Plasma membrane (GO:0005886) 11080149,12126233 nucleus 89 2 nucleus. plasma membrane multiple Chordata Chordata Eumetazoa VGF HGNC:12684 VGF nerve growth factor inducible O15240 Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus. Extracellular (GO:0005576) 9344675 cytoplasm 15 0 secreted secreted Theria Theria Mammalia VGLL1 HGNC:20985 vestigial-like family member 1 Q99990 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Bilateria VGLL2 HGNC:20232 vestigial-like family member 2 Q8N8G2 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12376544,12376544 nucleus 83 0 cytoplasm. nucleus multiple Chordata Chordata Bilateria VGLL3 HGNC:24327 vestigial-like family member 3 A8MV65 Nucleus (By similarity). nucleus 32 0 nucleus nucleus Theria Euteleostomi Bilateria VGLL4 HGNC:28966 vestigial-like family member 4 Q14135 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15140898,15140898 nucleus 83 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eumetazoa VHL HGNC:12687 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase P40337 Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Isoform 3: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated. Mitochondrion (GO:0005739); Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737); Nucleus (GO:0005634); Endoplasmic reticulum (GO:0005783) 10850420,9651579,8765323,8700833,10850420,7604013,8700833,9651579 nucleus 29 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus multiple Euteleostomi Eukaryota Bilateria VHLL HGNC:30666 von Hippel-Lindau tumor suppressor-like Q6RSH7 Nucleus (GO:0005634) secreted 34 0 secreted secreted Human Human Eukaryota VIL1 HGNC:12690 villin 1 P09327 Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip (By similarity). Cell projection, filopodium (By similarity). Note=Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12445810,12445810 cytoplasm 39 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota VILL HGNC:30906 villin-like O15195 Cytoskeleton (GO:0005856) cytoplasm 29 0 cytoplasm cytoplasm Bilateria Eukaryota Eukaryota VIM HGNC:12692 vimentin P08670 Cytoplasm. Intermediate filament (GO:0005882); Nucleolus (GO:0005730); Extracellular (GO:0005576); Membrane fraction (GO:0005624); Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783); Nucleus (GO:0005634); Cytoskeleton (GO:0005856); Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 14762106,9190204,12429849,15635413,12483219,17152095,12483219,12483219,16678164,17081983,15561729,15598749,17081983 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus. mitochondrion. nucleus. secreted multiple Chordata Chordata Holozoa VIMP HGNC:30396 VCP-interacting membrane protein Q9BQE4 Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (By similarity). endoplasmic reticulum membrane 5 1 endoplasmic reticulum membrane endoplasmic reticulum membrane NA NA Eumetazoa VIP HGNC:12693 vasoactive intestinal peptide P01282 Secreted. Cytoplasm (GO:0005737); Extracellular (GO:0005576) 15169929,15169929 secreted 100 0 cytoplasm. secreted multiple Tetrapoda Euteleostomi Bilateria VIPAS39 HGNC:20347 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Q9H9C1 Cytoplasm (By similarity). Cytoplasmic vesicle (By similarity). Early endosome. Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (By similarity). nucleus 54 0 endosome endosome Bilateria Eukaryota Eukaryota VIPR1 HGNC:12694 vasoactive intestinal peptide receptor 1 P32241 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11834941,11160313,12690118 plasma membrane 100 7 plasma membrane plasma membrane Euteleostomi Euteleostomi Holozoa VIPR2 HGNC:12695 vasoactive intestinal peptide receptor 2 P41587 Cell membrane; Multi-pass membrane protein. Plasma membrane (GO:0005886) 11728828 plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Holozoa VIT HGNC:12697 vitrin Q6UXI7 Secreted, extracellular space, extracellular matrix (By similarity). Extracellular (GO:0005576) secreted 80 0 secreted secreted Euteleostomi Euteleostomi Cell.Organisms VKORC1 HGNC:23663 vitamin K epoxide reductase complex, subunit 1 Q9BQB6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 14765194 endoplasmic reticulum membrane 100 3 endoplasmic reticulum. endoplasmic reticulum membrane multiple Deuterostomia Eukaryota Holozoa VKORC1L1 HGNC:21492 vitamin K epoxide reductase complex, subunit 1-like 1 Q8N0U8 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 37 3 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota VLDLR HGNC:12698 very low density lipoprotein receptor P98155 Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Membrane fraction (GO:0005624) 15082773 plasma membrane 27 0 n/a n/a Euteleostomi Bilateria Cell.Organisms VMA21 HGNC:22082 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) Q3ZAQ7 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. mitochondrion membrane 40 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Bilateria Bilateria VMAC HGNC:33803 vimentin-type intermediate filament associated coiled-coil protein Q2NL98 Cytoplasm (By similarity). Note=Colocalizes with vimentin-type intermediate filaments (By similarity). Cytoplasm (GO:0005737) 14985129 cytoplasm 70 0 cytoplasm cytoplasm Theria Chordata Deuterostomia VMO1 HGNC:30387 vitelline membrane outer layer 1 homolog (chicken) Q7Z5L0 Secreted (Probable). Extracellular (GO:0005576) secreted 46 0 secreted secreted Euteleostomi Eukaryota Cell.Organisms VMP1 HGNC:29559 vacuole membrane protein 1 Q96GC9 Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum. Golgi apparatus (GO:0005794); Endoplasmic reticulum (GO:0005783) 11785947,11785947 endoplasmic reticulum membrane 47 7 endoplasmic reticulum. golgi apparatus. plasma membrane multiple Eukaryota Eukaryota Cell.Organisms VN1R1 HGNC:13548 vomeronasal 1 receptor 1 Q9GZP7 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane Mammalia Tetrapoda Craniata VN1R2 HGNC:19872 vomeronasal 1 receptor 2 Q8NFZ6 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 9 plasma membrane plasma membrane Homininae Euteleostomi Craniata VN1R3 HGNC:19867 vomeronasal 1 receptor 3 (gene/pseudogene) Q9BXE9 Cell membrane; Multi-pass membrane protein. plasma membrane 100 7 plasma membrane plasma membrane NA NA NA VN1R4 HGNC:19871 vomeronasal 1 receptor 4 Q7Z5H5 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane NA NA Craniata VN1R5 HGNC:19870 vomeronasal 1 receptor 5 (gene/pseudogene) Q7Z5H4 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Homininae Homininae NA VNN1 HGNC:12705 vanin 1 O95497 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Plasma membrane (GO:0005886) 8934567 secreted 32 1 plasma membrane plasma membrane Tetrapoda Bilateria Cell.Organisms VNN2 HGNC:12706 vanin 2 O95498 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Cytoplasmic vesicle (GO:0016023); Plasma membrane (GO:0005886) 11200068,11200068 secreted 28 1 plasma membrane plasma membrane Tetrapoda Bilateria Cell.Organisms VNN3 HGNC:16431 vanin 3 Q9NY84 Cell membrane; Lipid-anchor, GPI-anchor (Potential). Note=According to PubMed:11491533, secreted (By similarity). Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11491533,11491533 secreted 32 0 secreted secreted Tetrapoda Bilateria Cell.Organisms VOPP1 HGNC:34518 vesicular, overexpressed in cancer, prosurvival protein 1 Q96AW1 Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions. Golgi apparatus (GO:0005794); Endosome (GO:0005768); Perinuclear region (GO:0048471); Nucleus (GO:0005634) 16381901,11256614,16381901,11256614,15735698,15735698 secreted 86 1 cytoplasm. endosome. golgi apparatus. nucleus multiple NA NA Deuterostomia VPRBP HGNC:30911 Vpr (HIV-1) binding protein Q9Y4B6 Cytoplasm. Nucleus. Cytoplasm (GO:0005737) 11223251 nucleus 20 0 cytoplasm. nucleus multiple Bilateria Eukaryota NA VPREB1 HGNC:12709 pre-B lymphocyte 1 P12018 Plasma membrane (GO:0005886); Extracellular (GO:0005576) 7961773,9058786 secreted 25 0 secreted secreted Mammalia Mammalia Cell.Organisms VPREB3 HGNC:12710 pre-B lymphocyte 3 Q9UKI3 Endoplasmic reticulum (GO:0005783); Plasma membrane (GO:0005886) 10702669,7961773 secreted 31 0 endoplasmic reticulum endoplasmic reticulum Eutheria Amniota Cell.Organisms VPS11 HGNC:14583 vacuolar protein sorting 11 homolog (S. cerevisiae) Q9H270 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Endosome (GO:0005768); Lysosome (GO:0005764); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 11250079,11382755,11250079,11382755,11382755,11382755 endoplasmic reticulum membrane 16 0 cytoplasm. endosome. lysosome multiple Eukaryota Eukaryota NA VPS13A HGNC:1908 vacuolar protein sorting 13 homolog A (S. cerevisiae) Q96RL7 nucleus 38 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota VPS13B HGNC:2183 vacuolar protein sorting 13 homolog B (yeast) Q7Z7G8 Plasma membrane (GO:0005886);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12730828/17081983,17081983 nucleus 37 2 cytoplasm. nucleus. plasma membrane multiple Deuterostomia Bilateria Eukaryota VPS13C HGNC:23594 vacuolar protein sorting 13 homolog C (S. cerevisiae) Q709C8 Nucleus (GO:0005634) 17081983 nucleus 56 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota VPS13D HGNC:23595 vacuolar protein sorting 13 homolog D (S. cerevisiae) Q5THJ4 Cytoplasm (GO:0005737) nucleus 56 2 nucleus nucleus Bilateria Eukaryota Eukaryota VPS16 HGNC:14584 vacuolar protein sorting 16 homolog (S. cerevisiae) Q9H269 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Late endosome (GO:0005770); Lysosome (GO:0005764); Membrane fraction (GO:0005624); Cytoplasm (GO:0005737) 11382755,11382755,11382755,11382755 nucleus 34 0 cytoplasm. endosome. lysosome multiple Eukaryota Eukaryota Eukaryota VPS18 HGNC:15972 vacuolar protein sorting 18 homolog (S. cerevisiae) Q9P253 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Cytoplasm (GO:0005737); Lysosome (GO:0005764) 11250079,11382755,17081983,11382755 nucleus 72 0 cytoplasm. lysosome multiple Eukaryota Eukaryota Eukaryota VPS25 HGNC:28122 vacuolar protein sorting 25 homolog (S. cerevisiae) Q9BRG1 Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6. Endosome (GO:0005768); Nucleus (GO:0005634) 16371348,16371348 nucleus 39 0 cytoplasm. endosome. nucleus multiple Eukaryota Eukaryota Eukaryota VPS26A HGNC:12711 vacuolar protein sorting 26 homolog A (S. pombe) O75436 Cytoplasm. Endosome membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Integral to membrane (GO:0016021); Endoplasmic reticulum (GO:0005783) 11102511,11102511,11102511 mitochondrion 23 0 cytoplasm. endoplasmic reticulum multiple Eukaryota Eukaryota Eukaryota VPS26B HGNC:28119 vacuolar protein sorting 26 homolog B (S. pombe) Q4G0F5 Cytoplasm. Membrane; Peripheral membrane protein. Note=Does not localize to endosomes (By similarity). Plasma membrane (GO:0005886); Cytosol (GO:0005829) 16190980,16190980 cytoplasm 15 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota VPS28 HGNC:18178 vacuolar protein sorting 28 homolog (S. cerevisiae) Q9UK41 Cell membrane. Late endosome membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Endosome (GO:0005768) 11916981,11916981 nucleus 48 0 cytoplasm. endosome multiple Eukaryota Eukaryota NA VPS29 HGNC:14340 vacuolar protein sorting 29 homolog (S. cerevisiae) Q9UBQ0 Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein (By similarity). Endosome (GO:0005768); Golgi apparatus (GO:0005794) 9700157,9700157 secreted 33 0 cytoplasm. endosome. golgi apparatus multiple Eukaryota Cell.Organisms Cell.Organisms VPS33A HGNC:18179 vacuolar protein sorting 33 homolog A (S. cerevisiae) Q96AX1 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes (By similarity). Golgi apparatus (GO:0005794); Lysosome (GO:0005764) 8996080,8996080 vacuole 20 1 golgi apparatus. lysosome multiple Eukaryota Eukaryota Eukaryota VPS33B HGNC:12712 vacuolar protein sorting 33 homolog B (yeast) Q9H267 Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles. Cytoplasm (GO:0005737) 11250079 vacuole 13 1 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota VPS35 HGNC:13487 vacuolar protein sorting 35 homolog (S. cerevisiae) Q96QK1 Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Endosome (GO:0005768); Membrane fraction (GO:0005624) 11102511,11102511,11102511,11102511,11102511,17215244 nucleus 71 0 cytoplasm. endoplasmic reticulum. endosome. golgi apparatus multiple Eukaryota Eukaryota Eukaryota VPS36 HGNC:20312 vacuolar protein sorting 36 homolog (S. cerevisiae) Q86VN1 Cytoplasm. Endosome. Late endosome. Membrane. Nucleus (Probable). Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. cytoplasm 34 0 cytoplasm. endosome. nucleus multiple Eukaryota Eukaryota Eukaryota VPS37A HGNC:24928 vacuolar protein sorting 37 homolog A (S. cerevisiae) Q8NEZ2 Late endosome membrane; Peripheral membrane protein. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Endosome (GO:0005768) 14623289,15240819,14623289,15240819,15509564 nucleus 45 0 cytoplasm. endosome. nucleus multiple Euteleostomi Bilateria Eukaryota VPS37B HGNC:25754 vacuolar protein sorting 37 homolog B (S. cerevisiae) Q9H9H4 Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A- dependent fashion. Cytoplasm (GO:0005737); Endosome (GO:0005768) 15218037,15218037 cytoplasm 21 0 cytoplasm. endosome multiple Bilateria Bilateria Holozoa VPS37C HGNC:26097 vacuolar protein sorting 37 homolog C (S. cerevisiae) A5D8V6 Late endosome membrane; Peripheral membrane protein (Probable). Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1. Plasma membrane (GO:0005886); Cytoplasmic vesicle (GO:0016023); Endosome (GO:0005768) 15509564,15509564,15509564 secreted 21 0 endosome endosome Amniota Euteleostomi Eukaryota VPS37D HGNC:18287 vacuolar protein sorting 37 homolog D (S. cerevisiae) Q86XT2 Late endosome membrane; Peripheral membrane protein (Probable). nucleus 49 0 nucleus nucleus Theria Euteleostomi NA VPS39 HGNC:20593 vacuolar protein sorting 39 homolog (S. cerevisiae) Q96JC1 Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. Lysosome (GO:0005764); Cytoplasm (GO:0005737) 11448994,11448994 cytoplasm 9 0 cytoplasm. lysosome multiple Eukaryota Eukaryota Eukaryota VPS41 HGNC:12713 vacuolar protein sorting 41 homolog (S. cerevisiae) P49754 Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 11412045,11412045 nucleus 91 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota VPS45 HGNC:14579 vacuolar protein sorting 45 homolog (S. cerevisiae) Q9NRW7 Golgi apparatus membrane; Peripheral membrane protein (By similarity). Endosome membrane; Peripheral membrane protein (By similarity). Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network (By similarity). Golgi apparatus (GO:0005794) 9045632 cytoplasm 10 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota VPS4A HGNC:13488 vacuolar protein sorting 4 homolog A (S. cerevisiae) Q9UN37 Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. Cytoplasm (GO:0005737); Perinuclear region (GO:0048471) 10637304,12594041 nucleus 32 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms VPS4B HGNC:10895 vacuolar protein sorting 4 homolog B (S. cerevisiae) O75351 Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells. Perinuclear region (GO:0048471) 12594041 nucleus 33 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms VPS51 HGNC:1172 vacuolar protein sorting 51 homolog (S. cerevisiae) Q9UID3 Golgi apparatus, trans-Golgi network. golgi apparatus 100 0 golgi apparatus golgi apparatus Eukaryota Eukaryota Eukaryota VPS52 HGNC:10518 vacuolar protein sorting 52 homolog (S. cerevisiae) Q8N1B4 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Cytoplasm (GO:0005737) golgi apparatus 21 0 golgi apparatus golgi apparatus Theria Eukaryota NA VPS53 HGNC:25608 vacuolar protein sorting 53 homolog (S. cerevisiae) Q5VIR6 Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. nucleus 69 0 nucleus nucleus Eukaryota Eukaryota Eukaryota VPS54 HGNC:18652 vacuolar protein sorting 54 homolog (S. cerevisiae) Q9P1Q0 Golgi apparatus (GO:0005794) 10637310 golgi apparatus 100 0 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota VPS72 HGNC:11644 vacuolar protein sorting 72 homolog (S. cerevisiae) Q15906 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota VPS8 HGNC:29122 vacuolar protein sorting 8 homolog (S. cerevisiae) Q8N3P4 golgi apparatus 5 0 golgi apparatus golgi apparatus Opisthokonta Eukaryota Eukaryota VPS9D1 HGNC:13526 VPS9 domain containing 1 Q9Y2B5 cytoplasm 23 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Holozoa VRK1 HGNC:12718 vaccinia related kinase 1 Q99986 Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle (By similarity). Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis. Nucleus (GO:0005634); Nucleolus (GO:0005730) 11883897,15635413 nucleus 22 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms VRK2 HGNC:12719 vaccinia related kinase 2 Q86Y07 Isoform 1: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Potential). Mitochondrion membrane; Single-pass type IV membrane protein (Potential). Isoform 2: Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,16963744 nucleus 20 1 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Cell.Organisms VRK3 HGNC:18996 vaccinia related kinase 3 Q8IV63 Nucleus. Nucleus (GO:0005634) 14645249 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms VRTN HGNC:20223 vertebrae development associated Q9H8Y1 Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Theria Euteleostomi Bilateria VSIG1 HGNC:28675 V-set and immunoglobulin domain containing 1 Q86XK7 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 20 1 plasma membrane plasma membrane Eutheria Amniota Eumetazoa VSIG10 HGNC:26078 V-set and immunoglobulin domain containing 10 Q8N0Z9 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) secreted 10 1 secreted secreted Euteleostomi Euteleostomi Metazoa VSIG10L HGNC:27111 V-set and immunoglobulin domain containing 10 like Q86VR7 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 10 1 plasma membrane plasma membrane NA NA Eumetazoa VSIG2 HGNC:17149 V-set and immunoglobulin domain containing 2 Q96IQ7 Membrane; Single-pass type I membrane protein (Potential). Plasma membrane (GO:0005886) 9862345 plasma membrane 21 1 plasma membrane plasma membrane Theria Tetrapoda Metazoa VSIG4 HGNC:17032 V-set and immunoglobulin domain containing 4 Q9Y279 Membrane; Single-pass type I membrane protein (Probable). Plasma membrane (GO:0005886); Endosome (GO:0005768) 11997108,16530040,16530040 plasma membrane 19 1 endosome. plasma membrane multiple Amniota Amniota Eumetazoa VSIG8 HGNC:32063 V-set and immunoglobulin domain containing 8 Q5VU13 Membrane; Single-pass type I membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 18 1 plasma membrane plasma membrane NA NA Eumetazoa VSNL1 HGNC:12722 visinin-like 1 P62760 Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 12200122,12200122,12445467 plasma membrane 21 0 cytoplasm cytoplasm Chordata Chordata Eukaryota VSTM1 HGNC:29455 V-set and transmembrane domain containing 1 Q6UX27 Isoform 1: Membrane; Single-pass membrane protein (Probable). Isoform 2: Secreted. plasma membrane 22 1 secreted secreted Homininae Eutheria NA VSTM2A HGNC:28499 V-set and transmembrane domain containing 2A Q8TAG5 Secreted (Potential). plasma membrane 72 1 plasma membrane plasma membrane Amniota Euteleostomi Craniata VSTM2B HGNC:33595 V-set and transmembrane domain containing 2B A6NLU5 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 81 0 n/a n/a Theria Tetrapoda Craniata VSTM2L HGNC:16096 V-set and transmembrane domain containing 2 like Q96N03 plasma membrane 86 0 n/a n/a Euteleostomi Euteleostomi Bilateria VSTM4 HGNC:26470 V-set and transmembrane domain containing 4 Q8IW00 Cell membrane; Single-pass type I membrane protein (Potential). secreted 31 1 secreted secreted Mammalia Euteleostomi Craniata VSTM5 HGNC:34443 V-set and transmembrane domain containing 5 A8MXK1 Membrane; Single-pass type I membrane protein (Potential). plasma membrane 69 1 plasma membrane plasma membrane Mammalia Euteleostomi Euteleostomi VSX1 HGNC:12723 visual system homeobox 1 Q9NZR4 Nucleus (By similarity). Nucleus (GO:0005634) 10903837 nucleus 48 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota VSX2 HGNC:1975 visual system homeobox 2 P58304 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Opisthokonta VTA1 HGNC:20954 vesicle (multivesicular body) trafficking 1 Q9NP79 Cytoplasm. Endosome membrane; Peripheral membrane protein (Probable). plasma membrane 11 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota VTCN1 HGNC:28873 V-set domain containing T cell activation inhibitor 1 Q7Z7D3 Cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected. Plasma membrane (GO:0005886) 12818166,12818165 plasma membrane 12 2 plasma membrane plasma membrane Tetrapoda Euteleostomi Craniata VTI1A HGNC:17792 vesicle transport through interaction with t-SNAREs 1A Q96AJ9 Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Integral to membrane (GO:0016021) golgi apparatus membrane 94 1 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota VTI1B HGNC:17793 vesicle transport through interaction with t-SNAREs 1B Q9UEU0 Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule. Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794); Lysosome (GO:0005764); Endosome (GO:0005768) 12067063,12067063,12067063,12067063 golgi apparatus membrane 90 1 endosome. endosome membrane. golgi apparatus. lysosome multiple Human Deuterostomia Eukaryota VTN HGNC:12724 vitronectin P04004 Secreted, extracellular space. Extracellular (GO:0005576) 2479556,16188874,15561729 secreted 100 0 secreted secreted NA NA NA VWA1 HGNC:30910 von Willebrand factor A domain containing 1 Q6PCB0 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Extracellular (GO:0005576) 12062410 secreted 16 0 secreted secreted Tetrapoda Euteleostomi Cell.Organisms VWA2 HGNC:24709 von Willebrand factor A domain containing 2 Q5GFL6 Secreted. Extracellular (GO:0005576) 15580307,14506275 secreted 100 0 secreted secreted Amniota Euteleostomi Eukaryota VWA3A HGNC:27088 von Willebrand factor A domain containing 3A A6NCI4 Secreted (Potential). secreted 19 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms VWA3B HGNC:28385 von Willebrand factor A domain containing 3B Q502W6 secreted 16 0 secreted secreted Deuterostomia Deuterostomia Cell.Organisms VWA5A HGNC:6658 von Willebrand factor A domain containing 5A O00534 Cytoplasm (GO:0005737) 9417908 secreted 4 0 cytoplasm cytoplasm Euteleostomi Eukaryota Cell.Organisms VWA5B1 HGNC:26538 von Willebrand factor A domain containing 5B1 Q5TIE3 Secreted (Potential). secreted 12 0 secreted secreted Euteleostomi Deuterostomia Cell.Organisms VWA5B2 HGNC:25144 von Willebrand factor A domain containing 5B2 Q8N398 cytoplasm 23 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Cell.Organisms VWA7 HGNC:13939 von Willebrand factor A domain containing 7 Q9Y334 Secreted (Potential). secreted 14 0 secreted secreted Euteleostomi Euteleostomi NA VWA8 HGNC:29071 von Willebrand factor A domain containing 8 A3KMH1 Secreted (Potential). nucleus 12 0 nucleus nucleus Bilateria Cell.Organisms Cell.Organisms VWA9 HGNC:25372 von Willebrand factor A domain containing 9 Q96SY0 nucleus 49 0 nucleus nucleus Deuterostomia Bilateria Eukaryota VWC2 HGNC:30200 von Willebrand factor C domain containing 2 Q2TAL6 Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Cell junction, synapse (By similarity). secreted 28 0 secreted secreted Amniota Euteleostomi Bilateria VWC2L HGNC:37203 von Willebrand factor C domain containing protein 2-like B2RUY7 Secreted (By similarity). Cell junction, synapse (By similarity). secreted 28 0 secreted secreted Euteleostomi Euteleostomi Bilateria VWCE HGNC:26487 von Willebrand factor C and EGF domains Q96DN2 Secreted (Potential). Note=According to PubMed:16496348 is localized in the cytoplasm. Extracellular (GO:0005576); Cytoplasm (GO:0005737) ,12869306 secreted 28 0 secreted secreted Mammalia Mammalia Eukaryota VWDE HGNC:21897 von Willebrand factor D and EGF domains Q8N2E2 Secreted (Potential). secreted 30 0 secreted secreted NA NA Eukaryota VWF HGNC:12726 von Willebrand factor P04275 Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules. Cytoplasm (GO:0005737); Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Secretory granule (GO:0030141) 11698279,3488775,10831592,2788784,2650559,3305020,10669107,2788160,10669107 secreted 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus. secreted multiple Chordata Bilateria Eukaryota WAC HGNC:17327 WW domain containing adaptor with coiled-coil Q9BTA9 Nucleus speckle (By similarity). Nucleus. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes (By similarity). Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11827461/17081983,17081983 nucleus 94 0 cytoplasm. nucleus multiple Euteleostomi Bilateria Eukaryota WAPAL HGNC:23293 wings apart-like homolog (Drosophila) Q7Z5K2 Isoform 2: Nucleus. Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase. Nucleus (GO:0005634); Nucleolus (GO:0005730); Chromosome (GO:0005694); Cytoplasm (GO:0005737) 15383329,15383329,17113138,17113138 nucleus 42 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota WARS HGNC:12729 tryptophanyl-tRNA synthetase P23381 Cytoplasm. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 7925483,15598749 cytoplasm 100 0 cytoplasm. mitochondrion multiple Cell.Organisms Cell.Organisms Cell.Organisms WARS2 HGNC:12730 tryptophanyl tRNA synthetase 2, mitochondrial Q9UGM6 Mitochondrion matrix. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10072595,10828066,10828066,10828066 mitochondrion 100 0 cytoplasm. mitochondrion. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms WAS HGNC:12731 Wiskott-Aldrich syndrome P42768 Cytoplasm, cytoskeleton. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 8625410,12600272,8625410,12600272 cytoplasm 100 0 cytoplasm. nucleus multiple Euteleostomi Bilateria NA WASF1 HGNC:12732 WAS protein family, member 1 Q92558 Cytoplasm, cytoskeleton. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane- ruffling areas. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 9843499,9843499 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Bilateria Eukaryota WASF2 HGNC:12733 WAS protein family, member 2 Q9Y6W5 Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By similarity). Note=At the interface between the lamellipodial actin meshwork and the membrane (By similarity). Cytoplasm (GO:0005737) 12181570,17101133,17081983 cytoplasm 40 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota WASF3 HGNC:12734 WAS protein family, member 3 Q9UPY6 Cytoplasm, cytoskeleton. Nucleus (GO:0005634) 10048485 cytoplasm 100 0 cytoplasm. nucleus multiple Chordata Bilateria Eukaryota WASH1 HGNC:24361 WAS protein family homolog 1 A8K0Z3 Early endosome membrane. Recycling endosome membrane (By similarity). Note=Localization to the endodome membrane is mediated via its interaction with FAM21. secreted 19 0 secreted secreted Deuterostomia Eukaryota NA WASL HGNC:12735 Wiskott-Aldrich syndrome-like O00401 Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Cytoplasm (GO:0005737); Extracellular (GO:0005576) 10704453,11830518 cytoplasm 61 0 cytoplasm. secreted multiple Chordata Eukaryota Eukaryota WBP1 HGNC:12737 WW domain binding protein 1 Q96G27 secreted 86 1 secreted secreted NA NA Euteleostomi WBP11 HGNC:16461 WW domain binding protein 11 Q9Y2W2 Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Co-localized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin. Nucleus (GO:0005634); Integral to membrane (GO:0016021); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 10593949,17081983,11375989,15635413,17081983 nucleus 48 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa WBP1L HGNC:23510 WW domain binding protein 1-like Q9NX94 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 45 1 secreted secreted Amniota Euteleostomi Eumetazoa WBP2 HGNC:12738 WW domain binding protein 2 Q969T9 secreted 24 0 secreted secreted Chordata Opisthokonta Opisthokonta WBP2NL HGNC:28389 WBP2 N-terminal like Q6ICG8 Acrosome (GO:0001669); Cytoplasm (GO:0005737); Nucleoplasm (GO:0005654) 17289678,17289678,17289678 secreted 47 0 cytoplasm. lysosome. nucleus multiple Theria Theria Eukaryota WBP4 HGNC:12739 WW domain binding protein 4 O75554 Nucleus speckle. Nucleus (GO:0005634) 9724750,17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota WBP5 HGNC:30084 WW domain binding protein 5 Q9UHQ7 nucleus 42 0 nucleus nucleus Euarchontoglires Euarchontoglires Eutheria WBSCR16 HGNC:14948 Williams-Beuren syndrome chromosome region 16 Q96I51 cytoplasm 15 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms WBSCR17 HGNC:16347 Williams-Beuren syndrome chromosome region 17 Q6IS24 Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus (GO:0005794) golgi apparatus membrane 28 1 golgi apparatus membrane golgi apparatus membrane Euteleostomi Euteleostomi Cell.Organisms WBSCR22 HGNC:16405 Williams Beuren syndrome chromosome region 22 O43709 Nucleus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 87 0 nucleus nucleus Eukaryota Eukaryota NA WBSCR27 HGNC:19068 Williams Beuren syndrome chromosome region 27 Q8N6F8 cytoplasm 53 0 cytoplasm cytoplasm Deuterostomia Cell.Organisms NA WBSCR28 HGNC:23018 Williams-Beuren syndrome chromosome region 28 Q6UE05 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) secreted 51 6 n/a n/a Eutheria Eutheria NA WDFY1 HGNC:20451 WD repeat and FYVE domain containing 1 Q8IWB7 Early endosome. Endosome (GO:0005768) 11739631 cytoplasm 10 0 endosome endosome Amniota Euteleostomi Cell.Organisms WDFY2 HGNC:20482 WD repeat and FYVE domain containing 2 Q96P53 nucleus 34 0 nucleus nucleus Bilateria Bilateria Cell.Organisms WDFY3 HGNC:20751 WD repeat and FYVE domain containing 3 Q8IZQ1 Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Co-localizes with autophagic structures in starved cells. nucleus 30 6 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDFY4 HGNC:29323 WDFY family member 4 Q6ZS81 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum 21 4 endoplasmic reticulum endoplasmic reticulum Opisthokonta Eukaryota Cell.Organisms WDHD1 HGNC:23170 WD repeat and HMG-box DNA binding protein 1 O75717 Nucleus, nucleoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 10 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms WDPCP HGNC:28027 WD repeat containing planar cell polarity effector O95876 Cell membrane (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). nucleus 57 1 nucleus nucleus Deuterostomia Bilateria Metazoa WDR1 HGNC:12754 WD repeat domain 1 O75083 Cytoplasm, cytoskeleton (By similarity). Cell projection, podosome. Cytoplasm (GO:0005737) cytoplasm 35 0 cytoplasm cytoplasm Human Eukaryota Cell.Organisms WDR11 HGNC:13831 WD repeat domain 11 Q9BZH6 Membrane; Single-pass membrane protein (Potential). Cytoplasm. Nucleus. Note=Might be shuttling between the nucleus and the cytoplasm. nucleus 69 1 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota WDR12 HGNC:14098 WD repeat domain 12 Q9GZL7 Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleolus (GO:0005730) 15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR13 HGNC:14352 WD repeat domain 13 Q9H1Z4 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12659815,12659815 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota NA WDR16 HGNC:16053 WD repeat domain 16 Q8N1V2 Cytoplasm. Cytoplasm (GO:0005737) 15967112 cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WDR17 HGNC:16661 WD repeat domain 17 Q8IZU2 nucleus 9 0 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms WDR18 HGNC:17956 WD repeat domain 18 Q9BV38 Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Nucleolus (GO:0005730) 15635413,11790298 nucleus 7 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR19 HGNC:18340 WD repeat domain 19 Q8NEZ3 Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in kidney cells (By similarity). nucleus 23 1 nucleus nucleus Bilateria Eukaryota Eukaryota WDR20 HGNC:19667 WD repeat domain 20 Q8TBZ3 nucleus 19 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDR24 HGNC:20852 WD repeat domain 24 Q96S15 nucleus 22 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDR25 HGNC:21064 WD repeat domain 25 Q64LD2 nucleus 8 1 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms WDR26 HGNC:21208 WD repeat domain 26 Q9H7D7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms WDR27 HGNC:21248 WD repeat domain 27 A2RRH5 nucleus 5 0 nucleus nucleus NA NA Cell.Organisms WDR3 HGNC:12755 WD repeat domain 3 Q9UNX4 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730) 10395803,15635413,11790298 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR31 HGNC:21421 WD repeat domain 31 Q8NA23 nucleus 8 0 nucleus nucleus Amniota Eukaryota Cell.Organisms WDR33 HGNC:25651 WD repeat domain 33 Q9C0J8 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11162572,17000644,11162572 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms WDR34 HGNC:28296 WD repeat domain 34 Q96EX3 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WDR35 HGNC:29250 WD repeat domain 35 Q9P2L0 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). cytoplasm 90 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms WDR36 HGNC:30696 WD repeat domain 36 Q8NI36 Nucleus, nucleolus. Nucleolus (GO:0005730) 15635413 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR37 HGNC:31406 WD repeat domain 37 Q9Y2I8 cytoplasm 8 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms WDR38 HGNC:23745 WD repeat domain 38 Q5JTN6 cytoplasm 15 0 cytoplasm cytoplasm Theria Chordata Cell.Organisms WDR4 HGNC:12756 WD repeat domain 4 P57081 Nucleus. nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota WDR41 HGNC:25601 WD repeat domain 41 Q9HAD4 nucleus 29 0 nucleus nucleus Euteleostomi Deuterostomia Cell.Organisms WDR43 HGNC:28945 WD repeat domain 43 Q15061 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR44 HGNC:30512 WD repeat domain 44 Q5JSH3 Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia (By similarity). Cytoplasm (GO:0005737); Cytoskeleton (GO:0005856) 10464283,17081983,10464283 nucleus 8 0 cytoplasm. golgi apparatus multiple Opisthokonta Eukaryota Cell.Organisms WDR45 HGNC:28912 WD repeat domain 45 Q9Y484 nucleus 70 0 nucleus nucleus Euteleostomi Opisthokonta NA WDR45B HGNC:25072 WD repeat domain 45B Q5MNZ6 cytoplasm 21 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota WDR46 HGNC:13923 WD repeat domain 46 O15213 Nucleolus (GO:0005730) 15635413,11790298 nucleus 29 0 nucleus nucleus NA NA NA WDR47 HGNC:29141 WD repeat domain 47 O94967 Cytoplasm, cytoskeleton (By similarity). Note=Localization along microtubules is mediated by MAP1S (By similarity). cytoplasm 94 0 cytoplasm cytoplasm Chordata Eukaryota Cell.Organisms WDR48 HGNC:30914 WD repeat domain 48 Q8TAF3 Nucleus. Cytoplasm. Lysosome. Note=Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11. Endosome (GO:0005768); Lysosome (GO:0005764); Cytoplasm (GO:0005737) 12196293,12196293,12196293 cytoplasm 11 0 cytoplasm. endosome. lysosome. nucleus multiple Opisthokonta Eukaryota Cell.Organisms WDR49 HGNC:26587 WD repeat domain 49 Q8IV35 nucleus 6 1 nucleus nucleus Deuterostomia Deuterostomia Cell.Organisms WDR5 HGNC:12757 WD repeat domain 5 P61964 Nucleus. Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Nucleus (GO:0005634) 14657013,15635413,,15199122,16253997, nucleus 100 0 cytoplasm. nucleus multiple Opisthokonta Eukaryota Cell.Organisms WDR52 HGNC:25631 WD repeat domain 52 Q96MT7 cytoplasm 18 1 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WDR53 HGNC:28786 WD repeat domain 53 Q7Z5U6 nucleus 8 0 nucleus nucleus Tetrapoda Eukaryota Cell.Organisms WDR54 HGNC:25770 WD repeat domain 54 Q9H977 nucleus 7 0 nucleus nucleus Theria Eukaryota Cell.Organisms WDR55 HGNC:25971 WD repeat domain 55 Q9H6Y2 Nucleus, nucleolus (By similarity). Cytoplasm (By similarity). nucleus 53 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR59 HGNC:25706 WD repeat domain 59 Q6PJI9 nucleus 8 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDR5B HGNC:17826 WD repeat domain 5B Q86VZ2 nucleus 83 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDR6 HGNC:12758 WD repeat domain 6 Q9NNW5 Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1. Plasma membrane (GO:0005886) 10903905 cytoplasm 100 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms WDR60 HGNC:21862 WD repeat domain 60 Q8WVS4 cytoplasm 20 1 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota WDR61 HGNC:30300 WD repeat domain 61 Q9GZS3 Nucleus. Cytoplasm (Probable). nucleus 11 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms WDR62 HGNC:24502 WD repeat domain 62 O43379 Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Cytoplasm (GO:0005737) 17081983 cytoplasm 9 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms WDR63 HGNC:30711 WD repeat domain 63 Q8IWG1 cytoplasm 14 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota WDR64 HGNC:26570 WD repeat domain 64 B1ANS9 cytoplasm 6 1 cytoplasm cytoplasm Amniota Deuterostomia Cell.Organisms WDR65 HGNC:26485 WD repeat domain 65 Q96MR6 cytoplasm 6 0 cytoplasm cytoplasm NA NA Cell.Organisms WDR66 HGNC:28506 WD repeat domain 66 Q8TBY9 cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WDR7 HGNC:13490 WD repeat domain 7 Q9Y4E6 Cytoplasmic vesicle (GO:0016023) 12786944 nucleus 25 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms WDR70 HGNC:25495 WD repeat domain 70 Q9NW82 Cytoplasm (GO:0005737) 17081983 nucleus 12 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms WDR72 HGNC:26790 WD repeat domain 72 Q3MJ13 cytoplasm 15 0 cytoplasm cytoplasm Tetrapoda Tetrapoda Cell.Organisms WDR73 HGNC:25928 WD repeat domain 73 Q6P4I2 nucleus 12 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria WDR74 HGNC:25529 WD repeat domain 74 Q6RFH5 Nucleus, nucleolus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR75 HGNC:25725 WD repeat domain 75 Q8IWA0 Nucleus, nucleolus. nucleus 100 1 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDR76 HGNC:25773 WD repeat domain 76 Q9H967 nucleus 13 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota WDR77 HGNC:29652 WD repeat domain 77 Q9BQA1 Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors. Nucleus (GO:0005634) ,,16253997, cytoplasm 9 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Cell.Organisms WDR78 HGNC:26252 WD repeat domain 78 Q5VTH9 cytoplasm 15 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WDR81 HGNC:26600 WD repeat domain 81 Q562E7 endoplasmic reticulum 27 6 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Cell.Organisms WDR82 HGNC:28826 WD repeat domain 82 Q6UXN9 Nucleus. Note=Associates with chromatin. Nucleus (GO:0005634) ,16253997, nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Cell.Organisms WDR83 HGNC:32672 WD repeat domain 83 Q9BRX9 Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity). Partially nuclear (By similarity). Cytoplasm (GO:0005737) 15118098 nucleus 16 0 cytoplasm cytoplasm Eukaryota Eukaryota Cell.Organisms WDR83OS HGNC:30203 WD repeat domain 83 opposite strand Q9Y284 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 21 2 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota WDR86 HGNC:28020 WD repeat domain 86 Q86TI4 nucleus 14 0 nucleus nucleus Mammalia Mammalia Cell.Organisms WDR87 HGNC:29934 WD repeat domain 87 Q6ZQQ6 nucleus 4 4 nucleus nucleus Mammalia Mammalia Cell.Organisms WDR88 HGNC:26999 WD repeat domain 88 Q6ZMY6 nucleus 8 0 nucleus nucleus Tetrapoda Deuterostomia Cell.Organisms WDR89 HGNC:20489 WD repeat domain 89 Q96FK6 Nucleolus (GO:0005730) 15635413 nucleus 17 0 nucleus nucleus Opisthokonta Eukaryota Cell.Organisms WDR90 HGNC:26960 WD repeat domain 90 Q96KV7 cytoplasm 5 1 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WDR91 HGNC:24997 WD repeat domain 91 A4D1P6 cytoplasm 18 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms WDR92 HGNC:25176 WD repeat domain 92 Q96MX6 Nucleus (GO:0005634) nucleus 15 0 nucleus nucleus NA NA Eukaryota WDR93 HGNC:26924 WD repeat domain 93 Q6P2C0 nucleus 27 0 nucleus nucleus Mammalia Tetrapoda Eumetazoa WDR96 HGNC:26684 WD repeat domain 96 Q8NDM7 nucleus 10 1 nucleus nucleus Deuterostomia Eukaryota Eukaryota WDSUB1 HGNC:26697 WD repeat, sterile alpha motif and U-box domain containing 1 Q8N9V3 nucleus 13 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms WDTC1 HGNC:29175 WD and tetratricopeptide repeats 1 Q8N5D0 cytoplasm 19 0 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms WDYHV1 HGNC:25490 WDYHV motif containing 1 Q96HA8 Cytoplasm, cytosol (By similarity). Nucleus (By similarity). secreted 23 0 secreted secreted Bilateria Eukaryota Eukaryota WEE1 HGNC:12761 WEE1 G2 checkpoint kinase P30291 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7673359,7673359,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms WEE2 HGNC:19684 WEE1 homolog 2 (S. pombe) P0C1S8 Nucleus. nucleus 100 0 nucleus nucleus Mammalia Mammalia NA WFDC1 HGNC:15466 WAP four-disulfide core domain 1 Q9HC57 Secreted (Potential). Extracellular (GO:0005576) 10967136,14522910 secreted 77 0 secreted secreted Deuterostomia Deuterostomia Bilateria WFDC10A HGNC:16139 WAP four-disulfide core domain 10A Q9H1F0 Secreted (Potential). secreted 99 0 secreted secreted Euarchontoglires Eutheria Eutheria WFDC10B HGNC:20479 WAP four-disulfide core domain 10B Q8IUB3 Secreted (Potential). secreted 99 0 secreted secreted Catarrhini Eutheria Eutheria WFDC11 HGNC:20478 WAP four-disulfide core domain 11 Q8NEX6 Secreted (Potential). secreted 95 0 secreted secreted Eutheria Eutheria Eutheria WFDC12 HGNC:16115 WAP four-disulfide core domain 12 Q8WWY7 Secreted (Potential). secreted 35 0 secreted secreted Euarchontoglires Euarchontoglires Mammalia WFDC13 HGNC:16131 WAP four-disulfide core domain 13 Q8IUB5 Secreted (Potential). secreted 98 0 secreted secreted Eutheria Eutheria Eutheria WFDC2 HGNC:15939 WAP four-disulfide core domain 2 Q14508 Secreted. Extracellular (GO:0005576) 1686187 secreted 100 0 secreted secreted Mammalia Mammalia Eumetazoa WFDC3 HGNC:15957 WAP four-disulfide core domain 3 Q8IUB2 Secreted (Potential). secreted 26 0 secreted secreted Theria Deuterostomia Eumetazoa WFDC5 HGNC:20477 WAP four-disulfide core domain 5 Q8TCV5 Secreted (Potential). secreted 42 0 secreted secreted Mammalia Mammalia Eumetazoa WFDC6 HGNC:16164 WAP four-disulfide core domain 6 Q9BQY6 Secreted (Potential). secreted 33 0 secreted secreted NA NA Bilateria WFDC8 HGNC:16163 WAP four-disulfide core domain 8 Q8IUA0 Secreted (Potential). Extracellular (GO:0005576) secreted 31 1 secreted secreted Theria Bilateria Cell.Organisms WFDC9 HGNC:20380 WAP four-disulfide core domain 9 Q8NEX5 Secreted (Potential). secreted 94 0 secreted secreted Eutheria Eutheria Eutheria WFIKKN1 HGNC:30912 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 Q96NZ8 Secreted (By similarity). secreted 45 0 secreted secreted Chordata Bilateria Cell.Organisms WFIKKN2 HGNC:30916 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Q8TEU8 Secreted (By similarity). Extracellular (GO:0005576) 11928817 secreted 90 0 secreted secreted Chordata Bilateria Cell.Organisms WFS1 HGNC:12762 Wolfram syndrome 1 (wolframin) O76024 Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783) 11181571 endoplasmic reticulum membrane 100 9 endoplasmic reticulum. endoplasmic reticulum membrane multiple Chordata Bilateria Metazoa WHAMM HGNC:30493 WAS protein homolog associated with actin, golgi membranes and microtubules Q8TF30 Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. cytoplasm 10 0 cytoplasm. golgi apparatus multiple Euteleostomi Deuterostomia Eumetazoa WHSC1 HGNC:12766 Wolf-Hirschhorn syndrome candidate 1 O96028 Nucleus. Chromosome (Potential). Isoform 4: Cytoplasm. Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 15677557/15677557,17081983,15677557,15677557 nucleus 55 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms WHSC1L1 HGNC:12767 Wolf-Hirschhorn syndrome candidate 1-like 1 Q9BZ95 Nucleus (By similarity). Chromosome (By similarity). nucleus 46 0 nucleus nucleus Bilateria Bilateria Cell.Organisms WIBG HGNC:30258 within bgcn homolog (Drosophila) Q9BRP8 Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1. nucleus 53 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota WIF1 HGNC:18081 WNT inhibitory factor 1 Q9Y5W5 Secreted. Extracellular (GO:0005576) 10201374 secreted 100 0 secreted secreted Tetrapoda Bilateria Eukaryota WIPF1 HGNC:12736 WAS/WASL interacting protein family, member 1 O43516 Cytoplasmic vesicle (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell projection, ruffle. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). Cytoplasm (GO:0005737) 12147689 cytoplasm 31 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eukaryota WIPF2 HGNC:30923 WAS/WASL interacting protein family, member 2 Q8TF74 Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments. Cytoskeleton (GO:0005856) 12213210 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Opisthokonta WIPF3 HGNC:22004 WAS/WASL interacting protein family, member 3 A6NGB9 Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone (By similarity). Axon (GO:0030424); Cytoskeleton (GO:0005856); Cytosol (GO:0005829) 11553796,11553796,11553796 cytoplasm 100 0 cytoplasm cytoplasm Eutheria Eutheria Opisthokonta WIPI1 HGNC:25471 WD repeat domain, phosphoinositide interacting 1 Q5MNZ9 Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules. Cytoplasm (GO:0005737) 15602573 nucleus 12 0 cytoplasm. endosome. golgi apparatus multiple Opisthokonta Eukaryota Cell.Organisms WIPI2 HGNC:32225 WD repeat domain, phosphoinositide interacting 2 Q9Y4P8 Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side. Note=Enriched at preautophagosomal structure membranes in response to ptdIns3P. nucleus 10 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota WISP1 HGNC:12769 WNT1 inducible signaling pathway protein 1 O95388 Secreted. Extracellular (GO:0005576) 11571650 secreted 100 0 secreted secreted Human Chordata Bilateria WISP2 HGNC:12770 WNT1 inducible signaling pathway protein 2 O76076 Secreted (Probable). Extracellular (GO:0005576); Cytoplasm (GO:0005737) 12056810,12659671 secreted 37 0 cytoplasm. secreted multiple Euteleostomi Euteleostomi Bilateria WISP3 HGNC:12771 WNT1 inducible signaling pathway protein 3 O95389 Secreted (Probable). Extracellular (GO:0005576) 9843955 secreted 33 0 secreted secreted Euteleostomi Euteleostomi NA WIZ HGNC:30917 widely interspaced zinc finger motifs O95785 Nucleus (By similarity). Nucleus (GO:0005634) 16702210 nucleus 81 0 nucleus nucleus Euteleostomi Euteleostomi Bilateria WLS HGNC:30238 wntless Wnt ligand secretion mediator Q5T9L3 Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 61 8 golgi apparatus membrane golgi apparatus membrane Bilateria Bilateria Eumetazoa WNK1 HGNC:14540 WNK lysine deficient protein kinase 1 Q9H4A3 Cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11498583,17081983,17081983 cytoplasm 100 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms WNK2 HGNC:14542 WNK lysine deficient protein kinase 2 Q9Y3S1 Cytoplasm. Cell membrane. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 34 0 cytoplasm. nucleus multiple Bilateria Eukaryota Cell.Organisms WNK3 HGNC:14543 WNK lysine deficient protein kinase 3 Q9BYP7 Cytoplasm. cytoplasm 100 0 cytoplasm cytoplasm Bilateria Eukaryota NA WNK4 HGNC:14544 WNK lysine deficient protein kinase 4 Q96J92 Cell junction, tight junction (By similarity). Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity). Cytoplasm (GO:0005737) 11498583 secreted 85 1 cytoplasm cytoplasm Bilateria Eukaryota Cell.Organisms WNT1 HGNC:12774 wingless-type MMTV integration site family, member 1 P04628 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 2534596 secreted 100 0 secreted secreted Theria Bilateria Metazoa WNT10A HGNC:13829 wingless-type MMTV integration site family, member 10A Q9GZT5 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) secreted 100 0 secreted secreted Theria Bilateria Metazoa WNT10B HGNC:12775 wingless-type MMTV integration site family, member 10B O00744 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Theria Bilateria Metazoa WNT11 HGNC:12776 wingless-type MMTV integration site family, member 11 O96014 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Metazoa WNT16 HGNC:16267 wingless-type MMTV integration site family, member 16 Q9UBV4 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Euteleostomi Bilateria Metazoa WNT2 HGNC:12780 wingless-type MMTV integration site family member 2 P09544 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Amniota Amniota Metazoa WNT2B HGNC:12781 wingless-type MMTV integration site family, member 2B Q93097 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 1 secreted secreted Chordata Chordata Metazoa WNT3 HGNC:12782 wingless-type MMTV integration site family, member 3 P56703 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Euteleostomi Deuterostomia Metazoa WNT3A HGNC:15983 wingless-type MMTV integration site family, member 3A P56704 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Euteleostomi Deuterostomia Metazoa WNT4 HGNC:12783 wingless-type MMTV integration site family, member 4 P56705 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Human Bilateria Metazoa WNT5A HGNC:12784 wingless-type MMTV integration site family, member 5A P41221 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Deuterostomia Bilateria Metazoa WNT5B HGNC:16265 wingless-type MMTV integration site family, member 5B Q9H1J7 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Deuterostomia Bilateria Metazoa WNT6 HGNC:12785 wingless-type MMTV integration site family, member 6 Q9Y6F9 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Amniota Bilateria Metazoa WNT7A HGNC:12786 wingless-type MMTV integration site family, member 7A O00755 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Amniota Euteleostomi Metazoa WNT7B HGNC:12787 wingless-type MMTV integration site family, member 7B P56706 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Euteleostomi Bilateria Metazoa WNT8A HGNC:12788 wingless-type MMTV integration site family, member 8A Q9H1J5 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576); Cell surface (GO:0009986) 8167409,8167409 secreted 100 0 secreted secreted Eutheria Deuterostomia Metazoa WNT8B HGNC:12789 wingless-type MMTV integration site family, member 8B Q93098 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Amniota Euteleostomi Metazoa WNT9A HGNC:12778 wingless-type MMTV integration site family, member 9A O14904 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Deuterostomia Deuterostomia Metazoa WNT9B HGNC:12779 wingless-type MMTV integration site family, member 9B O14905 Secreted, extracellular space, extracellular matrix. Extracellular (GO:0005576) 8167409 secreted 100 0 secreted secreted Euteleostomi Bilateria Metazoa WRAP53 HGNC:25522 WD repeat containing, antisense to TP53 Q9BUR4 Nucleus, Cajal body. Cytoplasm. Nucleus (GO:0005634) 17081983 cytoplasm 13 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Cell.Organisms WRAP73 HGNC:12759 WD repeat containing, antisense to TP73 Q9P2S5 Cytoplasm (Potential). Cytoplasm (GO:0005737) 11401440 nucleus 14 0 cytoplasm cytoplasm Deuterostomia Eukaryota Cell.Organisms WRB HGNC:12790 tryptophan rich basic protein O00258 Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus (GO:0005634) 9544840 endoplasmic reticulum membrane 100 3 endoplasmic reticulum membrane. nucleus multiple Euteleostomi Opisthokonta Opisthokonta WRN HGNC:12791 Werner syndrome, RecQ helicase-like Q14191 Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation- induced WRN relocation. Nucleolus (GO:0005730); Nucleus (GO:0005634) 11971179,15733840,11328876 nucleus 100 0 nucleus nucleus Cell.Organisms Cell.Organisms Cell.Organisms WRNIP1 HGNC:20876 Werner helicase interacting protein 1 Q96S55 Nucleus (By similarity). Note=Colocalizes with WRN in granular structures in the nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/11301316 nucleus 94 0 cytoplasm. nucleus multiple Euteleostomi Cell.Organisms Cell.Organisms WSB1 HGNC:19221 WD repeat and SOCS box containing 1 Q9Y6I7 nucleus 14 0 nucleus nucleus Chordata Chordata Cell.Organisms WSB2 HGNC:19222 WD repeat and SOCS box containing 2 Q9NYS7 nucleus 10 0 nucleus nucleus Tetrapoda Tetrapoda Cell.Organisms WSCD1 HGNC:29060 WSC domain containing 1 Q658N2 Membrane; Single-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 17 0 n/a n/a Deuterostomia Bilateria Cell.Organisms WSCD2 HGNC:29117 WSC domain containing 2 Q2TBF2 Membrane; Single-pass membrane protein (Potential). plasma membrane 11 0 n/a n/a Deuterostomia Bilateria Cell.Organisms WT1 HGNC:12796 Wilms tumor 1 P19544 Nucleus. Nucleus, nucleolus. Cytoplasm (By similarity). Isoform 1: Nucleus speckle. Isoform 4: Nucleus, nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8621495,8393820,11001926,9366517,9784496,12970737,15982325 nucleus 50 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota WTAP HGNC:16846 Wilms tumor 1 associated protein Q15007 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634) 17081983,17081983/11001926 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota WTIP HGNC:20964 Wilms tumor 1 interacting protein A6NIX2 Cell junction, adherens junction. Nucleus (By similarity). Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell- cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). Nucleus (GO:0005634); Cytosol (GO:0005829); Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Actin filament (GO:0005884) 14736876,14736876,14736876,14736876,14736876,14736876 secreted 51 0 cytoplasm. endoplasmic reticulum. nucleus multiple Theria Bilateria Eukaryota WWC1 HGNC:29435 WW and C2 domain containing 1 Q8IX03 Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Co-localizes with PRKCZ in the perinuclear region. Cytoplasm (GO:0005737) 12559952 cytoplasm 41 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota WWC2 HGNC:24148 WW and C2 domain containing 2 Q6AWC2 cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Eukaryota WWC3 HGNC:29237 WWC family member 3 Q9ULE0 cytoplasm 11 0 cytoplasm cytoplasm Deuterostomia Bilateria Holozoa WWOX HGNC:12799 WW domain containing oxidoreductase Q9NZC7 Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus. Mitochondrion (GO:0005739); Nucleus (GO:0005634); Cytoplasm (GO:0005737); Cytosol (GO:0005829); Golgi apparatus (GO:0005794) 11058590,15580310,11058590,15580310,12514174,12514174,15070730,15580310,12514174,11719429 cytoplasm 38 0 cytoplasm. golgi apparatus. mitochondrion. nucleus multiple Human Opisthokonta Cell.Organisms WWP1 HGNC:17004 WW domain containing E3 ubiquitin protein ligase 1 Q9H0M0 Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Nucleus (GO:0005634) 17081983 nucleus 56 1 nucleus nucleus Bilateria Opisthokonta Eukaryota WWP2 HGNC:16804 WW domain containing E3 ubiquitin protein ligase 2 O00308 Nucleus. nucleus 100 0 nucleus nucleus Bilateria Opisthokonta Eukaryota WWTR1 HGNC:24042 WW domain containing transcription regulator 1 Q9GZV5 Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11118213,11118213,17081983 nucleus 45 0 cytoplasm. nucleus multiple Theria Euteleostomi Opisthokonta XAB2 HGNC:14089 XPA binding protein 2 Q9HCS7 Nucleus (By similarity). Note=Detected in the splicing complex carrying pre-mRNA (By similarity). Nucleus (GO:0005634) nucleus 99 0 nucleus nucleus Theria Eukaryota Cell.Organisms XAF1 HGNC:30932 XIAP associated factor 1 Q6GPH4 Cytoplasm. Nucleus. Mitochondrion. Isoform 1: Nucleus. Isoform 5: Nucleus. Nucleus (GO:0005634) 11175744 nucleus 15 0 cytoplasm. mitochondrion. nucleus multiple Amniota Eukaryota Eukaryota XAGE1A HGNC:4111 X antigen family, member 1A Q9HD64 mitochondrion 19 0 mitochondrion mitochondrion Catarrhini Catarrhini NA XAGE1B HGNC:25400 X antigen family, member 1B Q9HD64 mitochondrion 19 0 mitochondrion mitochondrion Catarrhini Catarrhini NA XAGE1C HGNC:30679 X antigen family, member 1C Q9HD64 mitochondrion 19 0 mitochondrion mitochondrion Catarrhini Catarrhini Primates XAGE1D HGNC:21508 X antigen family, member 1D Q9HD64 Nucleus (GO:0005634) 11774264 mitochondrion 19 0 nucleus nucleus Catarrhini Catarrhini Primates XAGE1E HGNC:18372 X antigen family, member 1E Q9HD64 mitochondrion 19 0 mitochondrion mitochondrion Catarrhini Catarrhini Primates XAGE2 HGNC:4112 X antigen family, member 2 Q96GT9 nucleus 44 0 nucleus nucleus Catarrhini Catarrhini Boreoeutheria XAGE2B HGNC:30680 X antigen family, member 2B Q96GT9 nucleus 44 0 nucleus nucleus Catarrhini Catarrhini NA XAGE3 HGNC:14618 X antigen family, member 3 Q8WTP9 nucleus 36 0 nucleus nucleus Catarrhini Catarrhini NA XAGE5 HGNC:30930 X antigen family, member 5 Q8WWM1 nucleus 38 0 nucleus nucleus Human Human NA XBP1 HGNC:12801 X-box binding protein 1 P17861 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 8349596,1718857,11813207,11813207 nucleus 100 1 cytoplasm. nucleus multiple Euteleostomi Bilateria Eumetazoa XCL1 HGNC:10645 chemokine (C motif) ligand 1 P47992 Secreted. Extracellular (GO:0005576) 9079718,9199871 secreted 100 0 secreted secreted Amniota Amniota Euteleostomi XCL2 HGNC:10646 chemokine (C motif) ligand 2 Q9UBD3 Secreted. Extracellular (GO:0005576) secreted 100 0 secreted secreted Amniota Amniota Euteleostomi XCR1 HGNC:1625 chemokine (C motif) receptor 1 P46094 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 7 plasma membrane plasma membrane Amniota Euteleostomi Eumetazoa XDH HGNC:12805 xanthine dehydrogenase P47989 Cytoplasm (By similarity). Peroxisome (By similarity). Secreted. Cytoplasm (GO:0005737); Peroxisome (GO:0005777); Extracellular (GO:0005576) 11960915,11993848,8373410,17081983,11993848,8373410,10968141,8135849 cytoplasm 39 0 cytoplasm. peroxisome. secreted multiple Bilateria Cell.Organisms Cell.Organisms XG HGNC:12806 Xg blood group P55808 Cell membrane; Single-pass type I membrane protein. Plasma membrane (GO:0005886) 10688843 plasma membrane 100 1 plasma membrane plasma membrane Catarrhini Theria Boreoeutheria XIAP HGNC:592 X-linked inhibitor of apoptosis P98170 Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11807766,11807766,14759516 cytoplasm 20 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota XIRP1 HGNC:14301 xin actin-binding repeat containing 1 Q702N8 Cell junction. Note=Colocalizes with actin stress fibers. Plasma membrane (GO:0005886) 15454575 secreted 100 0 secreted secreted Euteleostomi Euteleostomi Craniata XIRP2 HGNC:14303 xin actin-binding repeat containing 2 A4UGR9 Cell junction. Note=Colocalizes with actin stress fibers (By similarity). secreted 100 0 secreted secreted Euteleostomi Euteleostomi Eukaryota XK HGNC:12811 X-linked Kx blood group (McLeod syndrome) P51811 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886); Endoplasmic reticulum (GO:0005783); Cytoplasm (GO:0005737) 10849386,9647734,10556484,10556484,17081983 plasma membrane 32 11 cytoplasm. endoplasmic reticulum. plasma membrane multiple Euteleostomi Euteleostomi NA XKR3 HGNC:28778 XK, Kell blood group complex subunit-related family, member 3 Q5GH77 Cell membrane; Multi-pass membrane protein. plasma membrane 100 11 plasma membrane plasma membrane Homininae Homininae Deuterostomia XKR4 HGNC:29394 XK, Kell blood group complex subunit-related family, member 4 Q5GH76 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 16 10 plasma membrane plasma membrane Theria Bilateria Metazoa XKR5 HGNC:20782 XK, Kell blood group complex subunit-related family, member 5 Q6UX68 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) cytoplasm 15 8 cytoplasm cytoplasm Euteleostomi Euteleostomi NA XKR6 HGNC:27806 XK, Kell blood group complex subunit-related family, member 6 Q5GH73 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 15 10 plasma membrane plasma membrane Deuterostomia Bilateria Metazoa XKR7 HGNC:23062 XK, Kell blood group complex subunit-related family, member 7 Q5GH72 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 15 10 plasma membrane plasma membrane Theria Euteleostomi NA XKR8 HGNC:25508 XK, Kell blood group complex subunit-related family, member 8 Q9H6D3 Membrane; Multi-pass membrane protein (Potential). plasma membrane 100 8 plasma membrane plasma membrane Opisthokonta Eukaryota Eumetazoa XKR9 HGNC:20937 XK, Kell blood group complex subunit-related family, member 9 Q5GH70 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 18 10 plasma membrane plasma membrane NA NA Eumetazoa XKRX HGNC:29845 XK, Kell blood group complex subunit-related, X-linked Q6PP77 Cell membrane; Multi-pass membrane protein. plasma membrane 100 10 plasma membrane plasma membrane Euteleostomi Euteleostomi Chordata XKRY HGNC:18571 XK, Kell blood group complex subunit-related, Y-linked O14609 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 9381176 plasma membrane 40 3 plasma membrane plasma membrane NA NA NA XKRY2 HGNC:23922 XK, Kell blood group complex subunit-related, Y-linked 2 A2RUG3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) plasma membrane 52 3 plasma membrane plasma membrane Human Human NA XPA HGNC:12814 xeroderma pigmentosum, complementation group A P23025 Nucleus. Nucleus (GO:0005634) 11906820 nucleus 100 0 nucleus nucleus Opisthokonta Eukaryota Eukaryota XPC HGNC:12816 xeroderma pigmentosum, complementation group C Q01831 Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions. Nucleus (GO:0005634) 8692695 nucleus 93 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota XPNPEP1 HGNC:12822 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble Q9NQW7 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 11106490 cytoplasm 95 0 cytoplasm cytoplasm Eukaryota Cell.Organisms Cell.Organisms XPNPEP2 HGNC:12823 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound O43895 Cell membrane; Lipid-anchor, GPI-anchor. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737) 9375790,9628831,9375790 cytoplasm 30 1 cytoplasm. plasma membrane multiple Eukaryota Cell.Organisms Cell.Organisms XPNPEP3 HGNC:28052 X-prolyl aminopeptidase (aminopeptidase P) 3, putative Q9NQH7 Mitochondrion. mitochondrion 100 0 mitochondrion mitochondrion Opisthokonta Cell.Organisms Cell.Organisms XPO1 HGNC:12825 exportin 1 O14980 Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Kinetochore (GO:0000776); Cytosol (GO:0005829) 9368044,16511568,15561729,9368044,15635413,17363900,16263121 nucleus 44 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota XPO4 HGNC:17796 exportin 4 Q9C0E2 Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10944119,17081983,10944119 secreted 48 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota XPO5 HGNC:17675 exportin 5 Q9HAV4 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634) 11777942,15561729 nucleus 5 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota XPO6 HGNC:19733 exportin 6 Q96QU8 Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14592989,15302935,14592989,17081983 nucleus 7 4 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota XPO7 HGNC:14108 exportin 7 Q9UIA9 Cytoplasm. Nucleus (Probable). Nucleus, nuclear pore complex (Probable). Note=Shuttles between the nucleus and the cytoplasm (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11071879,11024021,11071879 nucleus 3 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota XPOT HGNC:12826 exportin, tRNA O43592 Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9660920,15561729,9660920 nucleus 1 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota XPR1 HGNC:12827 xenotropic and polytropic retrovirus receptor 1 Q9UBH6 Cell membrane; Multi-pass membrane protein (Probable). Plasma membrane (GO:0005886) 9927670 vacuole membrane 20 8 plasma membrane plasma membrane Opisthokonta Eukaryota Eukaryota XRCC1 HGNC:12828 X-ray repair complementing defective repair in Chinese hamster cells 1 P18887 Nucleus. Note=Accumulates at sites of DNA damage. Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 14500814,10611252,17081983,15635413,17081983 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota XRCC2 HGNC:12829 X-ray repair complementing defective repair in Chinese hamster cells 2 O43543 Nucleus. Nucleus (GO:0005634) 11301337 nucleus 100 1 nucleus nucleus Euteleostomi Eukaryota Cell.Organisms XRCC3 HGNC:12830 X-ray repair complementing defective repair in Chinese hamster cells 3 O43542 Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair. Nucleus (GO:0005634) 975276 nucleus 13 0 cytoplasm. mitochondrion. nucleus multiple Euteleostomi Eukaryota Cell.Organisms XRCC4 HGNC:12831 X-ray repair complementing defective repair in Chinese hamster cells 4 Q13426 Nucleus. Nucleus (GO:0005634);Nucleus (GO:0005634) 17081983/9352367,16439205 nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota XRCC5 HGNC:12833 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) P13010 Nucleus. Nucleus, nucleolus. Chromosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 12391174,17283121,19059367,11741501,15635413,15598749 nucleus 100 0 cytoplasm. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota XRCC6 HGNC:4055 X-ray repair complementing defective repair in Chinese hamster cells 6 P12956 Nucleus. Chromosome. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 7957065,11328876,17283121,9798959,1639139,11790298,15635413 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota XRCC6BP1 HGNC:29452 XRCC6 binding protein 1 Q9Y6H3 secreted 33 0 secreted secreted Eukaryota Eukaryota NA XRN1 HGNC:30654 5'-3' exoribonuclease 1 Q8IZH2 Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane. Cytoplasm (GO:0005737) 9802570,9049243,12515382,16364915 cytoplasm 100 0 cytoplasm cytoplasm Euteleostomi Eukaryota Eukaryota XRN2 HGNC:12836 5'-3' exoribonuclease 2 Q9H0D6 Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleolus (GO:0005730); Nucleus (GO:0005634) 17081983,17081983/15635413,15561729 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota XRRA1 HGNC:18868 X-ray radiation resistance associated 1 Q6P2D8 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12908878,12908878 plasma membrane 29 0 cytoplasm. nucleus multiple Theria Eukaryota Cell.Organisms XXYLT1 HGNC:26639 xyloside xylosyltransferase 1 Q8NBI6 Endoplasmic reticulum membrane; Single-pass type II membrane protein. endoplasmic reticulum membrane 100 1 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Bilateria Holozoa XYLB HGNC:12839 xylulokinase homolog (H. influenzae) O75191 cytoplasm 24 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms XYLT1 HGNC:15516 xylosyltransferase I Q86Y38 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Secreted (Probable). Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted. Extracellular (GO:0005576) 11814476,10383739,11087729 golgi apparatus membrane 9 0 secreted secreted Bilateria Eukaryota Cell.Organisms XYLT2 HGNC:15517 xylosyltransferase II Q9H1B5 Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Extracellular (GO:0005576); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Plasma membrane (GO:0005886) 11099377,11099377,11099377,11099377 golgi apparatus membrane 11 0 endoplasmic reticulum. golgi apparatus. secreted multiple Bilateria Eukaryota Cell.Organisms YAE1D1 HGNC:24857 Yae1 domain containing 1 Q9NRH1 nucleus 42 0 nucleus nucleus NA NA Eukaryota YAF2 HGNC:17363 YY1 associated factor 2 Q8IY57 Nucleus. Nucleus (GO:0005634) 11593398,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Metazoa YAP1 HGNC:16262 Yes-associated protein 1 P46937 Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Plasma membrane (GO:0005886) 12535517,12535517,10562288 cytoplasm 19 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota YARS HGNC:12840 tyrosyl-tRNA synthetase P54577 Cytoplasm. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 10102815,9427763 cytoplasm 100 0 cytoplasm. secreted multiple Cell.Organisms Cell.Organisms Cell.Organisms YARS2 HGNC:24249 tyrosyl-tRNA synthetase 2, mitochondrial Q9Y2Z4 Mitochondrion matrix. mitochondrion 100 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms YBEY HGNC:1299 ybeY metallopeptidase (putative) P58557 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Cell.Organisms Cell.Organisms YBX1 HGNC:8014 Y box binding protein 1 P67809 Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 9409758,12604611,12604611,9409758 nucleus 85 0 cytoplasm. nucleus. secreted multiple Euteleostomi Cell.Organisms Cell.Organisms YBX2 HGNC:17948 Y box binding protein 2 Q9Y2T7 Cytoplasm. Nucleus. Nucleus (GO:0005634) nucleus 46 0 cytoplasm. nucleus multiple Theria Theria Cell.Organisms YBX3 HGNC:2428 Y box binding protein 3 P16989 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 7628487,7628487 nucleus 46 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms YDJC HGNC:27158 YdjC homolog (bacterial) A8MPS7 cytoplasm 46 0 cytoplasm cytoplasm Chordata Cell.Organisms Cell.Organisms YEATS2 HGNC:25489 YEATS domain containing 2 Q9ULM3 Nucleus (Probable). nucleus 28 0 nucleus nucleus Mammalia Bilateria Eukaryota YEATS4 HGNC:24859 YEATS domain containing 4 O95619 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 10913114,11521196,11756182,11521196 nucleus 100 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota YES1 HGNC:12841 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 P07947 Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 2067846,2067846 cytoplasm 32 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms YIF1A HGNC:16688 Yip1 interacting factor homolog A (S. cerevisiae) O95070 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus (GO:0005794) 10970842 endoplasmic reticulum membrane 78 7 endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Eukaryota Eukaryota Eukaryota YIF1B HGNC:30511 Yip1 interacting factor homolog B (S. cerevisiae) Q5BJH7 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 68 7 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota YIPF1 HGNC:25231 Yip1 domain family, member 1 Q9Y548 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) 15466293 endoplasmic reticulum membrane 55 5 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota YIPF2 HGNC:28476 Yip1 domain family, member 2 Q9BWQ6 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 57 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota YIPF3 HGNC:21023 Yip1 domain family, member 3 Q9GZM5 Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note=Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated. endoplasmic reticulum membrane 48 5 cytoplasm. golgi apparatus membrane. plasma membrane multiple Amniota Bilateria Opisthokonta YIPF4 HGNC:28145 Yip1 domain family, member 4 Q9BSR8 Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. golgi apparatus membrane 100 5 golgi apparatus membrane golgi apparatus membrane Deuterostomia Bilateria Holozoa YIPF5 HGNC:24877 Yip1 domain family, member 5 Q969M3 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle. Note=Enriched at the endoplasmic reticulum exit sites. Incorporated into COPII coated vesicles. Golgi apparatus (GO:0005794) 15990086 endoplasmic reticulum membrane 55 5 endoplasmic reticulum membrane. golgi apparatus. golgi apparatus membrane multiple Eukaryota Eukaryota Eukaryota YIPF6 HGNC:28304 Yip1 domain family, member 6 Q96EC8 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 14 5 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota YIPF7 HGNC:26825 Yip1 domain family, member 7 Q8N8F6 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). endoplasmic reticulum membrane 77 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota YJEFN3 HGNC:24785 YjeF N-terminal domain containing 3 A6XGL0 mitochondrion 30 0 mitochondrion mitochondrion NA NA Cell.Organisms YKT6 HGNC:16959 YKT6 v-SNARE homolog (S. cerevisiae) O15498 Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794) 9211930,12388752,12388752 secreted 20 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Eukaryota Eukaryota Eukaryota YLPM1 HGNC:17798 YLP motif containing 1 P49750 Nucleus. Nucleus speckle (By similarity). Note=Migrates to nucleolar caps upon blockage of transcription. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota YME1L1 HGNC:12843 YME1-like 1 ATPase Q96TA2 Mitochondrion inner membrane. Mitochondrion (GO:0005739); Cytoplasm (GO:0005737) 10843804,10930580,10843804 mitochondrion membrane 45 1 cytoplasm. mitochondrion multiple Eukaryota Eukaryota Cell.Organisms YOD1 HGNC:25035 YOD1 deubiquitinase Q5VVQ6 cytoplasm 38 0 cytoplasm cytoplasm Eukaryota Eukaryota Eukaryota YPEL1 HGNC:12845 yippee-like 1 (Drosophila) O60688 Nucleus (By similarity). Centrosome (GO:0005813); Nucleolus (GO:0005730); Nucleus (GO:0005634) 15556292,15556292,11473580,15556292 nucleus 99 0 nucleus nucleus Bilateria Eukaryota Eukaryota YPEL2 HGNC:18326 yippee-like 2 (Drosophila) Q96QA6 Nucleus, nucleolus. Centrosome (GO:0005813); Nucleolus (GO:0005730) 15556292,15556292 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota YPEL3 HGNC:18327 yippee-like 3 (Drosophila) P61236 Nucleus, nucleolus. nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota YPEL4 HGNC:18328 yippee-like 4 (Drosophila) Q96NS1 Nucleus, nucleolus. Nucleus (GO:0005634); Nucleolus (GO:0005730); Centrosome (GO:0005813) 15556292,15556292,15556292 nucleus 100 0 nucleus nucleus Mammalia Opisthokonta Eukaryota YPEL5 HGNC:18329 yippee-like 5 (Drosophila) P62699 nucleus 34 0 nucleus nucleus Bilateria Eukaryota Eukaryota YRDC HGNC:28905 yrdC N(6)-threonylcarbamoyltransferase domain containing Q86U90 Mitochondrion (Potential). Membrane; Peripheral membrane protein. Note=Predominantly localized in the plasma membrane (By similarity). mitochondrion 15 0 mitochondrion mitochondrion Cell.Organisms Cell.Organisms Cell.Organisms YTHDC1 HGNC:30626 YTH domain containing 1 Q96MU7 Nucleus (By similarity). Note=Localizes to a novel subnuclear structure, the YT bodies (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737);Cytoplasm (GO:0005737) 17081983,17081983/15175272,10564280,10973987,15175272/17081983 nucleus 95 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eukaryota YTHDC2 HGNC:24721 YTH domain containing 2 Q9H6S0 Nucleus (GO:0005634) 17081983 nucleus 30 0 nucleus nucleus Bilateria Eukaryota Cell.Organisms YTHDF1 HGNC:15867 YTH domain family, member 1 Q9BYJ9 secreted 17 0 secreted secreted Deuterostomia Eukaryota Eukaryota YTHDF2 HGNC:31675 YTH domain family, member 2 Q9Y5A9 nucleus 12 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota YTHDF3 HGNC:26465 YTH domain family, member 3 Q7Z739 secreted 18 0 secreted secreted Deuterostomia Eukaryota NA YWHAB HGNC:12849 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta P31946 Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Mitochondrion (GO:0005739) 8037685,15696159,15598749 cytoplasm 81 0 cytoplasm. melanosome. mitochondrion multiple Chordata Chordata Eukaryota YWHAE HGNC:12851 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon P62258 Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Golgi apparatus (GO:0005794); Nucleolus (GO:0005730); Mitochondrion (GO:0005739) 11864996,15696159,11864996,16482218,9452471,15635413,15598749 cytoplasm 62 0 cytoplasm. golgi apparatus. melanosome. mitochondrion. nucleus multiple Eukaryota Eukaryota Eukaryota YWHAG HGNC:12852 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma P61981 Cytoplasm (By similarity). Cytoplasm (GO:0005737); Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Nucleus (GO:0005634) 8037685,15696159,8037685,10559254,16511572 cytoplasm 100 0 cytoplasm. endoplasmic reticulum. golgi apparatus. nucleus multiple Euteleostomi Euteleostomi Eukaryota YWHAH HGNC:12853 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta Q04917 Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11864996,15696159,11864996 cytoplasm 99 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eukaryota YWHAQ HGNC:12854 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta P27348 Cytoplasm. Note=In neurons, axonally transported to the nerve terminals. Cytoplasm (GO:0005737); Nucleus (GO:0005634); Cytosol (GO:0005829) 11864996,17215244,11864996,15561729 cytoplasm 100 0 cytoplasm. nucleus multiple Theria Amniota Eukaryota YWHAZ HGNC:12855 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta P63104 Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes. Cytoplasm (GO:0005737); Cytosol (GO:0005829); Plasma membrane (GO:0005886) 8037685,15696159,17081983,15225635,15225635 cytoplasm 88 0 cytoplasm. melanosome multiple Eukaryota Eukaryota Eukaryota YY1 HGNC:12856 YY1 transcription factor P25490 Nucleus matrix. Note=Associated with the nuclear matrix. Nucleus (GO:0005634) 10866666,19059367 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota YY1AP1 HGNC:30935 YY1 associated protein 1 Q9H869 Cytoplasm. Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11710830,14744866 nucleus 8 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Eukaryota YY2 HGNC:31684 YY2 transcription factor O15391 Nucleus (Probable). Nucleus (GO:0005634) nucleus 79 0 nucleus nucleus NA NA Eukaryota ZACN HGNC:29504 zinc activated ligand-gated ion channel Q401N2 Cell membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) plasma membrane 100 4 plasma membrane plasma membrane Theria Theria Euteleostomi ZADH2 HGNC:28697 zinc binding alcohol dehydrogenase domain containing 2 Q8N4Q0 Peroxisome (By similarity). peroxisome 85 0 peroxisome peroxisome Deuterostomia Eukaryota Cell.Organisms ZAN HGNC:12857 zonadhesin (gene/pseudogene) Q9Y493 Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head (By similarity). Plasma membrane (GO:0005886) 9126492 plasma membrane 100 1 plasma membrane plasma membrane Deuterostomia Bilateria Cell.Organisms ZAP70 HGNC:12858 zeta-chain (TCR) associated protein kinase 70kDa P43403 Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Co-localizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). Cytoplasm (GO:0005737); Plasma membrane (GO:0005886); Nucleus (GO:0005634) 8943371,8943371,9362531 plasma membrane 23 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Cell.Organisms ZAR1 HGNC:20436 zygote arrest 1 Q86SH2 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 12539046 cytoplasm 58 0 cytoplasm cytoplasm Theria Euteleostomi Bilateria ZAR1L HGNC:37116 zygote arrest 1-like A6NP61 cytoplasm 42 0 cytoplasm cytoplasm Human Amniota Bilateria ZBBX HGNC:26245 zinc finger, B-box domain containing A8MT70 nucleus 86 0 nucleus nucleus Tetrapoda Euteleostomi Metazoa ZBED1 HGNC:447 zinc finger, BED-type containing 1 O96006 Nucleus. Note=In granular structures. Nucleus (GO:0005634) 12663651 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota ZBED2 HGNC:20710 zinc finger, BED-type containing 2 Q9BTP6 Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Mammalia Mammalia Mammalia ZBED3 HGNC:20711 zinc finger, BED-type containing 3 Q96IU2 Cytoplasm (By similarity). Membrane (By similarity). Note=Colocalizes with AXIN1 in the cytoplasm (By similarity). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Homininae Homininae Mammalia ZBED4 HGNC:20721 zinc finger, BED-type containing 4 O75132 Nucleus. Cytoplasm. Nucleus (GO:0005634) nucleus 17 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ZBED5 HGNC:30803 zinc finger, BED-type containing 5 Q49AG3 nucleus 9 1 nucleus nucleus NA NA Opisthokonta ZBED6 HGNC:33273 zinc finger, BED-type containing 6 P86452 Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus (By similarity). nucleus 87 0 nucleus nucleus NA NA Eukaryota ZBED6CL HGNC:21720 ZBED6 C-terminal like Q96FA7 nucleus 17 0 nucleus nucleus Human Tetrapoda Tetrapoda ZBP1 HGNC:16176 Z-DNA binding protein 1 Q9H171 Cytoplasm (GO:0005737) 17618271 nucleus 66 0 cytoplasm cytoplasm Eutheria Eutheria Eutheria ZBTB1 HGNC:20259 zinc finger and BTB domain containing 1 Q9Y2K1 Nucleus (Potential). nucleus 16 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB10 HGNC:30953 zinc finger and BTB domain containing 10 Q96DT7 Nucleus (Potential). Nucleus (GO:0005634) nucleus 16 0 nucleus nucleus Theria Chordata Eukaryota ZBTB11 HGNC:16740 zinc finger and BTB domain containing 11 O95625 Nucleus (Potential). Nucleus (GO:0005634) 17081983 nucleus 23 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB12 HGNC:19066 zinc finger and BTB domain containing 12 Q9Y330 Nucleus (Potential). nucleus 19 0 nucleus nucleus Mammalia Euteleostomi NA ZBTB14 HGNC:12860 zinc finger and BTB domain containing 14 O43829 Nucleus. Note=Colocalizes with ZBTB21 in nucleus in HEK293 cells. Nucleus (GO:0005634) 9177479 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB16 HGNC:12930 zinc finger and BTB domain containing 16 Q05516 Nucleus. Nucleus (GO:0005634) 8541544,12970399 nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota ZBTB17 HGNC:12936 zinc finger and BTB domain containing 17 Q13105 Nucleus. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11545736,15095404,11545736,15095404 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota ZBTB18 HGNC:13030 zinc finger and BTB domain containing 18 Q99592 Nucleus. Note=Associates with condensed chromatin. Nucleus (GO:0005634); Chromosome (GO:0005694) 9756912,10721697 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB2 HGNC:20868 zinc finger and BTB domain containing 2 Q8N680 Nucleus (Potential). Nucleus (GO:0005634) nucleus 27 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB20 HGNC:13503 zinc finger and BTB domain containing 20 Q9HC78 Nucleus (By similarity). Nucleus (GO:0005634) 11352661 nucleus 24 0 nucleus nucleus Theria Euteleostomi Eukaryota ZBTB21 HGNC:13083 zinc finger and BTB domain containing 21 Q9ULJ3 Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells. Nucleus (GO:0005634) none,17081983 nucleus 100 0 nucleus nucleus Eutheria Euteleostomi Eukaryota ZBTB22 HGNC:13085 zinc finger and BTB domain containing 22 O15209 Nucleus (Probable). Nucleus (GO:0005634) nucleus 17 0 nucleus nucleus Theria Euteleostomi NA ZBTB24 HGNC:21143 zinc finger and BTB domain containing 24 O43167 Nucleus (Potential). nucleus 34 0 nucleus nucleus Chordata Chordata Eukaryota ZBTB25 HGNC:13112 zinc finger and BTB domain containing 25 P24278 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Metazoa ZBTB26 HGNC:23383 zinc finger and BTB domain containing 26 Q9HCK0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB3 HGNC:22918 zinc finger and BTB domain containing 3 Q9H5J0 Nucleus (Potential). nucleus 27 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB32 HGNC:16763 zinc finger and BTB domain containing 32 Q9Y2Y4 Nucleus. Note=Located in nuclear speckles. Nucleus (GO:0005634) 10572087 nucleus 100 0 nucleus nucleus Eutheria Eutheria Eukaryota ZBTB33 HGNC:16682 zinc finger and BTB domain containing 33 Q86T24 Nucleus. Cytoplasm. Note=Also cytoplasmic in cells grown at high densities. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10207085,15781635,15564377,15781635 nucleus 86 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi NA ZBTB34 HGNC:31446 zinc finger and BTB domain containing 34 Q8NCN2 Nucleus. Nucleus (GO:0005634) 16718364 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB37 HGNC:28365 zinc finger and BTB domain containing 37 Q5TC79 Nucleus (Probable). nucleus 34 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB38 HGNC:26636 zinc finger and BTB domain containing 38 Q8NAP3 Nucleus (By similarity). nucleus 77 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZBTB39 HGNC:29014 zinc finger and BTB domain containing 39 O15060 Nucleus (Potential). Nucleus (GO:0005634) nucleus 11 1 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB4 HGNC:23847 zinc finger and BTB domain containing 4 Q9P1Z0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Theria Euteleostomi Eukaryota ZBTB40 HGNC:29045 zinc finger and BTB domain containing 40 Q9NUA8 Nucleus (Potential). Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 nucleus 22 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZBTB41 HGNC:24819 zinc finger and BTB domain containing 41 Q5SVQ8 Nucleus (Potential). nucleus 26 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB42 HGNC:32550 zinc finger and BTB domain containing 42 B2RXF5 Cytoplasm (By similarity). Nucleus. Nucleus, nucleoplasm (By similarity). Note=In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions (By similarity). nucleus 38 0 nucleus nucleus NA NA Eukaryota ZBTB43 HGNC:17908 zinc finger and BTB domain containing 43 O43298 Nucleus (Probable). Nucleus (GO:0005634) nucleus 18 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB44 HGNC:25001 zinc finger and BTB domain containing 44 Q8NCP5 Nucleus (By similarity). cytoplasm 17 0 cytoplasm cytoplasm Chordata Chordata Eukaryota ZBTB45 HGNC:23715 zinc finger and BTB domain containing 45 Q96K62 Nucleus (Potential). Nucleus (GO:0005634) nucleus 20 0 nucleus nucleus Euarchontoglires Tetrapoda Eukaryota ZBTB46 HGNC:16094 zinc finger and BTB domain containing 46 Q86UZ6 Nucleus (Potential). cytoplasm 10 0 cytoplasm cytoplasm Amniota Euteleostomi Eukaryota ZBTB47 HGNC:26955 zinc finger and BTB domain containing 47 Q9UFB7 Nucleus (Probable). nucleus 27 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB48 HGNC:4930 zinc finger and BTB domain containing 48 P10074 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB49 HGNC:19883 zinc finger and BTB domain containing 49 Q6ZSB9 Nucleus (Potential). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZBTB5 HGNC:23836 zinc finger and BTB domain containing 5 O15062 Nucleus (Potential). Nucleus (GO:0005634) nucleus 18 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZBTB6 HGNC:16764 zinc finger and BTB domain containing 6 Q15916 Nucleus. Nucleus (GO:0005634) 7958847 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota ZBTB7A HGNC:18078 zinc finger and BTB domain containing 7A O95365 Nucleus (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 9927193,11907272,17081983,11907272,11907272 nucleus 88 0 cytoplasm. nucleus multiple Amniota Euteleostomi Eukaryota ZBTB7B HGNC:18668 zinc finger and BTB domain containing 7B O15156 Nucleus. Nucleus (GO:0005634) 10856292 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota ZBTB7C HGNC:31700 zinc finger and BTB domain containing 7C A1YPR0 Nucleus (GO:0005634) nucleus 29 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZBTB8A HGNC:24172 zinc finger and BTB domain containing 8A Q96BR9 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 16 0 cytoplasm cytoplasm NA NA Eukaryota ZBTB8B HGNC:37057 zinc finger and BTB domain containing 8B Q8NAP8 Nucleus (Potential). cytoplasm 15 1 cytoplasm cytoplasm Tetrapoda Euteleostomi NA ZBTB8OS HGNC:24094 zinc finger and BTB domain containing 8 opposite strand Q8IWT0 cytoplasm 42 0 cytoplasm cytoplasm Bilateria Cell.Organisms Cell.Organisms ZBTB9 HGNC:28323 zinc finger and BTB domain containing 9 Q96C00 Nucleus (Potential). Nucleus (GO:0005634) nucleus 25 0 nucleus nucleus Theria Tetrapoda NA ZC2HC1A HGNC:24277 zinc finger, C2HC-type containing 1A Q96GY0 nucleus 71 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZC2HC1B HGNC:21174 zinc finger, C2HC-type containing 1B Q5TFG8 nucleus 69 0 nucleus nucleus Human Bilateria Eukaryota ZC2HC1C HGNC:20354 zinc finger, C2HC-type containing 1C Q53FD0 nucleus 87 0 nucleus nucleus Human Human Eukaryota ZC3H10 HGNC:25893 zinc finger CCCH-type containing 10 Q96K80 nucleus 11 0 nucleus nucleus Eutheria Deuterostomia Eukaryota ZC3H11A HGNC:29093 zinc finger CCCH-type containing 11A O75152 Nucleus (GO:0005634); Cytosol (GO:0005829) none,17081983,15561729 nucleus 28 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ZC3H12A HGNC:26259 zinc finger CCCH-type containing 12A Q5D1E8 Cytoplasm (By similarity). Nucleus. Nucleus (GO:0005634) 16574901 nucleus 41 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZC3H12B HGNC:17407 zinc finger CCCH-type containing 12B Q5HYM0 cytoplasm 51 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ZC3H12C HGNC:29362 zinc finger CCCH-type containing 12C Q9C0D7 cytoplasm 48 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ZC3H12D HGNC:21175 zinc finger CCCH-type containing 12D A2A288 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Nucleus. cytoplasm 59 0 cytoplasm. nucleus multiple Theria Eukaryota Eukaryota ZC3H13 HGNC:20368 zinc finger CCCH-type containing 13 Q5T200 nucleus 32 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa ZC3H14 HGNC:20509 zinc finger CCCH-type containing 14 Q6PJT7 Nucleus speckle. Isoform 1: Nucleus speckle. Isoform 3: Nucleus speckle. Isoform 6: Cytoplasm. Nucleus (GO:0005634);Nucleus (GO:0005634) /17081983 nucleus 87 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota ZC3H15 HGNC:29528 zinc finger CCCH-type containing 15 Q8WU90 Cytoplasm. Nucleus (By similarity). Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 cytoplasm 38 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ZC3H18 HGNC:25091 zinc finger CCCH-type containing 18 Q86VM9 Nucleus (By similarity). cytoplasm 36 0 cytoplasm cytoplasm Tetrapoda Euteleostomi Eumetazoa ZC3H3 HGNC:28972 zinc finger CCCH-type containing 3 Q8IXZ2 Nucleus (GO:0005634) none,17081983 nucleus 28 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota ZC3H4 HGNC:17808 zinc finger CCCH-type containing 4 Q9UPT8 plasma membrane 31 0 n/a n/a Mammalia Mammalia Eukaryota ZC3H6 HGNC:24762 zinc finger CCCH-type containing 6 P61129 Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZC3H7A HGNC:30959 zinc finger CCCH-type containing 7A Q8IWR0 Nucleus (Probable). Nucleus (GO:0005634) none,17081983 nucleus 37 0 nucleus nucleus Chordata Chordata Eukaryota ZC3H7B HGNC:30869 zinc finger CCCH-type containing 7B Q9UGR2 Nucleus. Note=Nuclear localization seems to be depleted upon rotavirus A infection. Nucleus (GO:0005634) none,15561729 nucleus 100 0 nucleus nucleus Chordata Chordata Eukaryota ZC3H8 HGNC:30941 zinc finger CCCH-type containing 8 Q8N5P1 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 74 0 nucleus nucleus Eutheria Eutheria Eukaryota ZC3HAV1 HGNC:23721 zinc finger CCCH-type, antiviral 1 Q7Z2W4 Isoform 1: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 14557641/17081983,17081983 cytoplasm 20 0 cytoplasm. nucleus multiple Theria Theria Eukaryota ZC3HAV1L HGNC:22423 zinc finger CCCH-type, antiviral 1-like Q96H79 secreted 29 0 secreted secreted Mammalia Mammalia Eumetazoa ZC3HC1 HGNC:29913 zinc finger, C3HC-type containing 1 Q86WB0 Nucleus. Nucleus (GO:0005634) 12748172 nucleus 100 0 nucleus nucleus Deuterostomia Opisthokonta Eukaryota ZC4H2 HGNC:24931 zinc finger, C4H2 domain containing Q9NQZ6 Cytoplasm. Nucleus. Cell junction, synapse, postsynaptic cell membrane. Note=Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites. nucleus 83 0 cytoplasm. nucleus multiple Chordata Bilateria Opisthokonta ZCCHC10 HGNC:25954 zinc finger, CCHC domain containing 10 Q8TBK6 nucleus 18 0 nucleus nucleus Human Euteleostomi Eukaryota ZCCHC11 HGNC:28981 zinc finger, CCHC domain containing 11 Q5TAX3 Nucleus. Cytoplasm. Note=Translocates into the cytoplasm following treatment of the cell with LPS. Nucleus (GO:0005634) cytoplasm 20 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota ZCCHC12 HGNC:27273 zinc finger, CCHC domain containing 12 Q6PEW1 nucleus 26 0 nucleus nucleus Euarchontoglires Eutheria Deuterostomia ZCCHC13 HGNC:31749 zinc finger, CCHC domain containing 13 Q8WW36 Nucleus (GO:0005634) nucleus 23 0 nucleus nucleus Human Human Eukaryota ZCCHC14 HGNC:24134 zinc finger, CCHC domain containing 14 Q8WYQ9 Nucleus (GO:0005634) plasma membrane 12 0 n/a n/a Tetrapoda Euteleostomi Craniata ZCCHC16 HGNC:25214 zinc finger, CCHC domain containing 16 Q6ZR62 Nucleus (GO:0005634) secreted 43 0 secreted secreted Euarchontoglires Eutheria Opisthokonta ZCCHC17 HGNC:30246 zinc finger, CCHC domain containing 17 Q9NP64 Nucleus, nucleolus. Nucleolus (GO:0005730); Nucleus (GO:0005634); Ribosome (GO:0005840); Cytoplasm (GO:0005737) 12893261,12202495,12893261,12202495,12202495,12202495 nucleus 100 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Cell.Organisms ZCCHC18 HGNC:32459 zinc finger, CCHC domain containing 18 P0CG32 nucleus 28 0 nucleus nucleus NA NA NA ZCCHC2 HGNC:22916 zinc finger, CCHC domain containing 2 Q9C0B9 Nucleus (GO:0005634) nucleus 25 0 nucleus nucleus Amniota Bilateria Holozoa ZCCHC23 HGNC:32963 zinc finger, CCHC domain containing 23 Q6ZST2 secreted 18 0 secreted secreted NA NA NA ZCCHC24 HGNC:26911 zinc finger, CCHC domain containing 24 Q8N2G6 Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 28 0 nucleus nucleus Human Eukaryota Holozoa ZCCHC3 HGNC:16230 zinc finger, CCHC domain containing 3 Q9NUD5 nucleus 39 0 nucleus nucleus Eutheria Euteleostomi Eukaryota ZCCHC4 HGNC:22917 zinc finger, CCHC domain containing 4 Q9H5U6 Nucleus (GO:0005634) nucleus 90 0 nucleus nucleus Bilateria Bilateria Holozoa ZCCHC5 HGNC:22997 zinc finger, CCHC domain containing 5 Q8N8U3 nucleus 16 0 nucleus nucleus Human Eutheria Opisthokonta ZCCHC6 HGNC:25817 zinc finger, CCHC domain containing 6 Q5VYS8 Nucleus (GO:0005634) cytoplasm 16 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ZCCHC7 HGNC:26209 zinc finger, CCHC domain containing 7 Q8N3Z6 Nucleus (GO:0005634) nucleus 25 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZCCHC8 HGNC:25265 zinc finger, CCHC domain containing 8 Q6NZY4 Nucleus (GO:0005634) 17081983 nucleus 65 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota ZCCHC9 HGNC:25424 zinc finger, CCHC domain containing 9 Q8N567 Nucleolus (GO:0005730); Nucleus (GO:0005634) 15635413,18721783 nucleus 23 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ZCRB1 HGNC:29620 zinc finger CCHC-type and RNA binding motif 1 Q8TBF4 Nucleus, nucleoplasm. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Eukaryota Cell.Organisms ZCWPW1 HGNC:23486 zinc finger, CW type with PWWP domain 1 Q9H0M4 Nucleus (GO:0005634) nucleus 20 0 nucleus nucleus Eutheria Chordata Eukaryota ZCWPW2 HGNC:23574 zinc finger, CW type with PWWP domain 2 Q504Y3 nucleus 19 0 nucleus nucleus Theria Eukaryota Eukaryota ZDBF2 HGNC:29313 zinc finger, DBF-type containing 2 Q9HCK1 nucleus 15 0 nucleus nucleus Amniota Amniota Chordata ZDHHC1 HGNC:17916 zinc finger, DHHC-type containing 1 Q8WTX9 Membrane; Multi-pass membrane protein (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10395086,10395086 endoplasmic reticulum membrane 27 4 cytoplasm. nucleus multiple Deuterostomia Eukaryota Eukaryota ZDHHC11 HGNC:19158 zinc finger, DHHC-type containing 11 Q9H8X9 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 22 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eukaryota Eukaryota ZDHHC11B HGNC:32962 zinc finger, DHHC-type containing 11B P0C7U3 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 24 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Eutheria Eukaryota Eukaryota ZDHHC12 HGNC:19159 zinc finger, DHHC-type containing 12 Q96GR4 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 15 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Deuterostomia Eukaryota Eukaryota ZDHHC13 HGNC:18413 zinc finger, DHHC-type containing 13 Q8IUH4 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 27 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Cell.Organisms Cell.Organisms ZDHHC14 HGNC:20341 zinc finger, DHHC-type containing 14 Q8IZN3 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 24 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota ZDHHC15 HGNC:20342 zinc finger, DHHC-type containing 15 Q96MV8 Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum (GO:0005783) vacuole membrane 22 4 vacuole membrane vacuole membrane Eukaryota Eukaryota Eukaryota ZDHHC16 HGNC:20714 zinc finger, DHHC-type containing 16 Q969W1 Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum (GO:0005783) 12021275 endoplasmic reticulum membrane 34 4 endoplasmic reticulum endoplasmic reticulum Bilateria Eukaryota Eukaryota ZDHHC17 HGNC:18412 zinc finger, DHHC-type containing 17 Q8IUH5 Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. Golgi apparatus (GO:0005794); Cytoplasm (GO:0005737) 12393793,12393793 nucleus 26 6 cytoplasm. golgi apparatus. golgi apparatus membrane multiple Eukaryota Cell.Organisms Cell.Organisms ZDHHC18 HGNC:20712 zinc finger, DHHC-type containing 18 Q9NUE0 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 26 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Eukaryota Eukaryota Eukaryota ZDHHC19 HGNC:20713 zinc finger, DHHC-type containing 19 Q8WVZ1 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 23 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Theria Eukaryota ZDHHC2 HGNC:18469 zinc finger, DHHC-type containing 2 Q9UIJ5 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) golgi apparatus membrane 21 4 golgi apparatus membrane golgi apparatus membrane Eukaryota Eukaryota Eukaryota ZDHHC20 HGNC:20749 zinc finger, DHHC-type containing 20 Q5W0Z9 Membrane; Multi-pass membrane protein (Potential). vacuole membrane 22 4 vacuole membrane vacuole membrane Eukaryota Eukaryota Eukaryota ZDHHC21 HGNC:20750 zinc finger, DHHC-type containing 21 Q8IVQ6 Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 16 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Tetrapoda Euteleostomi Eukaryota ZDHHC22 HGNC:20106 zinc finger, DHHC-type containing 22 Q8N966 Membrane; Multi-pass membrane protein (Potential). endoplasmic reticulum membrane 25 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Amniota Euteleostomi Eukaryota ZDHHC23 HGNC:28654 zinc finger, DHHC-type containing 23 Q8IYP9 Membrane; Multi-pass membrane protein (Potential). Plasma membrane (GO:0005886) 15105416 golgi apparatus membrane 27 6 plasma membrane plasma membrane Amniota Bilateria Eukaryota ZDHHC24 HGNC:27387 zinc finger, DHHC-type containing 24 Q6UX98 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 38 6 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Eukaryota Eukaryota ZDHHC3 HGNC:18470 zinc finger, DHHC-type containing 3 Q9NYG2 Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Golgi apparatus (GO:0005794) 15229235 golgi apparatus membrane 97 4 golgi apparatus golgi apparatus Bilateria Eukaryota Eukaryota ZDHHC4 HGNC:18471 zinc finger, DHHC-type containing 4 Q9NPG8 Membrane; Multi-pass membrane protein (Potential). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 18 5 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Eukaryota Eukaryota ZDHHC5 HGNC:18472 zinc finger, DHHC-type containing 5 Q9C0B5 Cell membrane; Multi-pass membrane protein (By similarity). Integral to membrane (GO:0016021) endoplasmic reticulum membrane 22 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Theria Euteleostomi Eukaryota ZDHHC6 HGNC:19160 zinc finger, DHHC-type containing 6 Q9H6R6 Endoplasmic reticulum membrane; Multi-pass membrane protein. Integral to membrane (GO:0016021) endoplasmic reticulum membrane 100 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Bilateria Eukaryota Eukaryota ZDHHC7 HGNC:18459 zinc finger, DHHC-type containing 7 Q9NXF8 Membrane; Multi-pass membrane protein (Potential). Golgi apparatus. Integral to membrane (GO:0016021) golgi apparatus membrane 57 4 golgi apparatus golgi apparatus Euteleostomi Euteleostomi Eukaryota ZDHHC8 HGNC:18474 zinc finger, DHHC-type containing 8 Q9ULC8 Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential). Cytoplasmic vesicle (GO:0016023) 15184899 endoplasmic reticulum membrane 19 4 endoplasmic reticulum membrane endoplasmic reticulum membrane Euteleostomi Bilateria Eukaryota ZDHHC9 HGNC:18475 zinc finger, DHHC-type containing 9 Q9Y397 Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. endoplasmic reticulum membrane 25 4 endoplasmic reticulum membrane. golgi apparatus membrane multiple Eukaryota Eukaryota Eukaryota ZEB1 HGNC:11642 zinc finger E-box binding homeobox 1 P37275 Nucleus. Nucleus (GO:0005634) 11760832,1840704 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZEB2 HGNC:14881 zinc finger E-box binding homeobox 2 O60315 Nucleus. Nucleus (GO:0005634) 11477103 nucleus 100 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZER1 HGNC:30960 zyg-11 related, cell cycle regulator Q7Z7L7 nucleus 54 0 nucleus nucleus Bilateria Bilateria Holozoa ZFAND1 HGNC:25858 zinc finger, AN1-type domain 1 Q8TCF1 endoplasmic reticulum 17 0 endoplasmic reticulum endoplasmic reticulum Euteleostomi Eukaryota Eukaryota ZFAND2A HGNC:28073 zinc finger, AN1-type domain 2A Q8N6M9 Cytoplasm (By similarity). Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11525245,11525245 endoplasmic reticulum 48 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ZFAND2B HGNC:25206 zinc finger, AN1-type domain 2B Q8WV99 Endoplasmic reticulum (By similarity). endoplasmic reticulum 88 0 endoplasmic reticulum endoplasmic reticulum Eukaryota Eukaryota Eukaryota ZFAND3 HGNC:18019 zinc finger, AN1-type domain 3 Q9H8U3 Nucleus (GO:0005634) 10366431 cytoplasm 12 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZFAND4 HGNC:23504 zinc finger, AN1-type domain 4 Q86XD8 cytoplasm 38 0 cytoplasm cytoplasm Deuterostomia Bilateria Cell.Organisms ZFAND5 HGNC:13008 zinc finger, AN1-type domain 5 O76080 Cytoplasm (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 16424905,16424905 cytoplasm 98 0 cytoplasm. nucleus multiple Chordata Eukaryota Eukaryota ZFAND6 HGNC:30164 zinc finger, AN1-type domain 6 Q6FIF0 Cytoplasm (By similarity). Cytoplasm (GO:0005737) 15698998 cytoplasm 93 0 cytoplasm cytoplasm Tetrapoda Eukaryota Eukaryota ZFAT HGNC:19899 zinc finger and AT hook domain containing Q9P243 Nucleus (By similarity). Cytoplasm, cytosol (By similarity). nucleus 17 0 nucleus nucleus Mammalia Euteleostomi Eukaryota ZFC3H1 HGNC:28328 zinc finger, C3H1-type containing O60293 nucleus 24 0 nucleus nucleus Chordata Chordata Eukaryota ZFHX2 HGNC:20152 zinc finger homeobox 2 Q9C0A1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Theria Tetrapoda Opisthokonta ZFHX3 HGNC:777 zinc finger homeobox 3 Q15911 Nucleus. Nucleus (GO:0005634) 1719379,19059367 nucleus 100 0 nucleus nucleus Tetrapoda Bilateria Eukaryota ZFHX4 HGNC:30939 zinc finger homeobox 4 Q86UP3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Tetrapoda Bilateria Opisthokonta ZFP1 HGNC:23328 ZFP1 zinc finger protein Q6P2D0 Nucleus (Probable). nucleus 49 0 nucleus nucleus Eutheria Eutheria Eukaryota ZFP14 HGNC:29312 ZFP14 zinc finger protein Q9HCL3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZFP2 HGNC:26138 ZFP2 zinc finger protein Q6ZN57 Nucleus (Probable). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZFP28 HGNC:17801 ZFP28 zinc finger protein Q8NHY6 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZFP3 HGNC:12861 ZFP3 zinc finger protein Q96NJ6 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZFP30 HGNC:29555 ZFP30 zinc finger protein Q9Y2G7 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZFP36 HGNC:12862 ZFP36 ring finger protein P26651 Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12823857,12115244,12823857,16364915 cytoplasm 34 0 cytoplasm. nucleus multiple Theria Tetrapoda Eukaryota ZFP36L1 HGNC:1107 ZFP36 ring finger protein-like 1 Q07352 Nucleus. Nucleus (GO:0005634) 8595910 cytoplasm 26 0 nucleus nucleus Theria Eukaryota Eukaryota ZFP36L2 HGNC:1108 ZFP36 ring finger protein-like 2 P47974 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 34 0 cytoplasm cytoplasm Euteleostomi Euteleostomi Eukaryota ZFP37 HGNC:12863 ZFP37 zinc finger protein Q9Y6Q3 Nucleus (Probable). Nucleus (GO:0005634) 9535899 nucleus 47 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZFP41 HGNC:26786 ZFP41 zinc finger protein Q8N8Y5 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 76 0 nucleus nucleus Human Eutheria Eukaryota ZFP42 HGNC:30949 ZFP42 zinc finger protein Q96MM3 Nucleus (By similarity). nucleus 62 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZFP57 HGNC:18791 ZFP57 zinc finger protein Q9NU63 Nucleus (By similarity). Note=Binds various differentially methylated regions (DMR), including the SNRPN DMR (By similarity). nucleus 33 0 nucleus nucleus Eutheria Eutheria NA ZFP62 HGNC:23241 ZFP62 zinc finger protein Q8NB50 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Bilateria Bilateria Eukaryota ZFP64 HGNC:15940 ZFP64 zinc finger protein Q9NPA5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 27 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZFP69 HGNC:24708 ZFP69 zinc finger protein Q49AA0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZFP69B HGNC:28053 ZFP69 zinc finger protein B Q9UJL9 Nucleus (Potential). nucleus 41 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZFP82 HGNC:28682 ZFP82 zinc finger protein Q8N141 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZFP90 HGNC:23329 ZFP90 zinc finger protein Q8TF47 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 78 0 nucleus nucleus Human Eutheria Eukaryota ZFP91 HGNC:14983 ZFP91 zinc finger protein Q96JP5 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12738986,17081983,17081983 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Eukaryota ZFP92 HGNC:12865 ZFP92 zinc finger protein A6NM28 Nucleus (By similarity). nucleus 42 0 nucleus nucleus Catarrhini Euarchontoglires NA ZFPL1 HGNC:12868 zinc finger protein-like 1 O95159 Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein. Nucleus (GO:0005634) 9653652 golgi apparatus membrane 100 1 golgi apparatus membrane. nucleus multiple Theria Eukaryota Eukaryota ZFPM1 HGNC:19762 zinc finger protein, FOG family member 1 Q8IX07 Nucleus (By similarity). nucleus 72 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZFPM2 HGNC:16700 zinc finger protein, FOG family member 2 Q8WW38 Nucleus. Nucleus (GO:0005634) 9927675 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa ZFR HGNC:17277 zinc finger RNA binding protein Q96KR1 Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasmic granule (By similarity). Chromosome (By similarity). Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). Nucleus (GO:0005634); Nucleolus (GO:0005730) 11574164,19059367,15635413 cytoplasm 42 0 nucleus nucleus Bilateria Bilateria Metazoa ZFR2 HGNC:29189 zinc finger RNA binding protein 2 Q9UPR6 cytoplasm 38 0 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ZFX HGNC:12869 zinc finger protein, X-linked P17010 Nucleus. Nucleus (GO:0005634) 2500252 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZFY HGNC:12870 zinc finger protein, Y-linked P08048 Nucleus. Nucleus (GO:0005634) 7680890 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZFYVE1 HGNC:13180 zinc finger, FYVE domain containing 1 Q9HBF4 Golgi apparatus, Golgi stack. Endoplasmic reticulum. Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Perinuclear region (GO:0048471);Cytoplasmic vesicle (GO:0016023); Golgi apparatus (GO:0005794); Cytosol (GO:0005829) 11739631,11739631,11739631/11024279,11256955,11256955,11256955 nucleus 21 0 cytoplasm. endoplasmic reticulum. golgi apparatus multiple Tetrapoda Bilateria Eukaryota ZFYVE16 HGNC:20756 zinc finger, FYVE domain containing 16 Q7Z3T8 Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P). Endosome (GO:0005768) 11546807 nucleus 26 0 cytoplasm. endosome multiple Bilateria Bilateria Eukaryota ZFYVE19 HGNC:20758 zinc finger, FYVE domain containing 19 Q96K21 Cytoplasm (GO:0005737) 17081983 nucleus 15 0 cytoplasm cytoplasm Euteleostomi Deuterostomia Eukaryota ZFYVE20 HGNC:20759 zinc finger, FYVE domain containing 20 Q9H1K0 Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Endosome (GO:0005768) 11062261 nucleus 32 0 endosome endosome Bilateria Bilateria Eukaryota ZFYVE21 HGNC:20760 zinc finger, FYVE domain containing 21 Q9BQ24 Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker. nucleus 28 0 endosome endosome Deuterostomia Eukaryota Eukaryota ZFYVE26 HGNC:20761 zinc finger, FYVE domain containing 26 Q68DK2 Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A. Endosome (GO:0005768); Nucleus (GO:0005634) ,17081983 nucleus 20 0 cytoplasm. endosome multiple Euteleostomi Eukaryota Eukaryota ZFYVE27 HGNC:26559 zinc finger, FYVE domain containing 27 Q5T4F4 Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes at both dendrites and axons (By similarity). Integral to membrane (GO:0016021) secreted 69 3 endoplasmic reticulum membrane. endosome. plasma membrane multiple Euteleostomi Euteleostomi Eukaryota ZFYVE28 HGNC:29334 zinc finger, FYVE domain containing 28 Q9HCC9 Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated. Endosome (GO:0005768) cytoplasm 29 1 cytoplasm cytoplasm Bilateria Bilateria Eukaryota ZFYVE9 HGNC:6775 zinc finger, FYVE domain containing 9 O95405 Cytoplasm. Early endosome membrane. Cytoplasm (GO:0005737); Early endosome (GO:0005769) 9865696,16601693 nucleus 29 0 cytoplasm. endosome multiple Bilateria Bilateria Eukaryota ZG16 HGNC:30961 zymogen granule protein 16 O60844 Secreted, extracellular space, extracellular matrix. Cytoplasmic vesicle lumen (Probable). Golgi apparatus lumen. Note=Stored in zymogen granules (By similarity). secreted 95 0 golgi apparatus. secreted multiple NA NA Cell.Organisms ZG16B HGNC:30456 zymogen granule protein 16B Q96DA0 Secreted (Potential). secreted 95 1 secreted secreted Catarrhini Eutheria Tetrapoda ZGLP1 HGNC:37245 zinc finger, GATA-like protein 1 P0C6A0 Nucleus (By similarity). nucleus 60 0 nucleus nucleus Homininae Euteleostomi Eukaryota ZGPAT HGNC:15948 zinc finger, CCCH-type with G patch domain Q8N5A5 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 100 0 nucleus nucleus Bilateria Eukaryota Eukaryota ZGRF1 HGNC:25654 zinc finger, GRF-type containing 1 Q86YA3 nucleus 85 0 nucleus nucleus Theria Theria Cell.Organisms ZHX1 HGNC:12871 zinc fingers and homeoboxes 1 Q9UKY1 Nucleus. Note=Colocalized in the nucleus with DNMT3B. Nucleus (GO:0005634) 10441475,12237128,12062805 nucleus 100 0 nucleus nucleus Tetrapoda Euteleostomi Chordata ZHX2 HGNC:18513 zinc fingers and homeoboxes 2 Q9Y6X8 Nucleus. Nucleus (GO:0005634) 12741956,14659886 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Chordata ZHX3 HGNC:15935 zinc fingers and homeoboxes 3 Q9H4I2 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12659632,12659632 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Euteleostomi Chordata ZIC1 HGNC:12872 Zic family member 1 Q15915 Nucleus. Cytoplasm (By similarity). Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Nucleus (GO:0005634) 8542595 nucleus 59 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZIC2 HGNC:12873 Zic family member 2 O95409 Nucleus. Cytoplasm (By similarity). Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity). Nucleus (GO:0005634) 11038359 nucleus 61 0 nucleus nucleus Theria Bilateria Eukaryota ZIC3 HGNC:12874 Zic family member 3 O60481 Nucleus. Cytoplasm (By similarity). Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. Nucleus (GO:0005634) 11238441 nucleus 58 0 nucleus nucleus Theria Euteleostomi Eukaryota ZIC4 HGNC:20393 Zic family member 4 Q8N9L1 Nucleus (By similarity). Nucleus (GO:0005634) 15465018 nucleus 82 0 nucleus nucleus Chordata Opisthokonta Eukaryota ZIC5 HGNC:20322 Zic family member 5 Q96T25 Nucleus (By similarity). Nucleus (GO:0005634) 15465018 nucleus 84 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZIK1 HGNC:33104 zinc finger protein interacting with K protein 1 Q3SY52 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZIM2 HGNC:12875 zinc finger, imprinted 2 Q9NZV7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 21 0 nucleus nucleus Eutheria Eutheria NA ZIM3 HGNC:16366 zinc finger, imprinted 3 Q96PE6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZKSCAN1 HGNC:13101 zinc finger with KRAB and SCAN domains 1 P17029 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 nucleus 50 0 nucleus nucleus Theria Theria Eukaryota ZKSCAN2 HGNC:25677 zinc finger with KRAB and SCAN domains 2 Q63HK3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Mammalia Mammalia Eukaryota ZKSCAN3 HGNC:13853 zinc finger with KRAB and SCAN domains 3 Q9BRR0 Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function. Nucleus (GO:0005634) nucleus 80 0 cytoplasm. nucleus multiple Theria Theria Eukaryota ZKSCAN4 HGNC:13854 zinc finger with KRAB and SCAN domains 4 Q969J2 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Theria Theria Eukaryota ZKSCAN5 HGNC:12867 zinc finger with KRAB and SCAN domains 5 Q9Y2L8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Theria Theria Eukaryota ZKSCAN7 HGNC:12955 zinc finger with KRAB and SCAN domains 7 Q9P0L1 Nucleus (Potential). Nucleus (GO:0005634) 1946370 nucleus 54 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZKSCAN8 HGNC:12983 zinc finger with KRAB and SCAN domains 8 Q15776 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Theria Theria Eukaryota ZMAT1 HGNC:29377 zinc finger, matrin-type 1 Q5H9K5 Nucleus (Potential). Nucleus (GO:0005634) cytoplasm 74 0 cytoplasm cytoplasm Eutheria Eutheria Opisthokonta ZMAT2 HGNC:26433 zinc finger, matrin-type 2 Q96NC0 Nucleus (Potential). Nucleus (GO:0005634); Nucleolus (GO:0005730) ,15635413 nucleus 4 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ZMAT3 HGNC:29983 zinc finger, matrin-type 3 Q9HA38 Nucleus. Nucleus, nucleolus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 11571644,12196512,11571644,12196512 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Bilateria Eukaryota ZMAT4 HGNC:25844 zinc finger, matrin-type 4 Q9H898 Nucleus (Potential). Nucleus (GO:0005634) nucleus 15 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa ZMAT5 HGNC:28046 zinc finger, matrin-type 5 Q9UDW3 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Eukaryota Opisthokonta ZMIZ1 HGNC:16493 zinc finger, MIZ-type containing 1 Q9ULJ6 Nucleus speckle. Cytoplasm. Nucleus (GO:0005634) 14609956 nucleus 53 0 cytoplasm. nucleus multiple Tetrapoda Deuterostomia Eukaryota ZMIZ2 HGNC:22229 zinc finger, MIZ-type containing 2 Q8NF64 Nucleus. Note=Detected at replication foci throughout S phase. Nucleus (GO:0005634) 16051670 nucleus 100 0 nucleus nucleus Tetrapoda Deuterostomia Eukaryota ZMPSTE24 HGNC:12877 zinc metallopeptidase STE24 O75844 Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum (GO:0005783); Golgi apparatus (GO:0005794); Mitochondrion (GO:0005739) 10076063,10076063,15598749 endoplasmic reticulum membrane 38 7 endoplasmic reticulum. endoplasmic reticulum membrane. golgi apparatus. mitochondrion. nucleus membrane multiple Eukaryota Cell.Organisms Cell.Organisms ZMYM1 HGNC:26253 zinc finger, MYM-type 1 Q5SVZ6 Nucleus (Potential). nucleus 25 0 nucleus nucleus Eutheria Eukaryota Eukaryota ZMYM2 HGNC:12989 zinc finger, MYM-type 2 Q9UBW7 Nucleus (Potential). Nucleolus (GO:0005730); Nucleus (GO:0005634) 10480903,10480903,15302935,9576949,12776193 nucleus 35 0 nucleus nucleus Deuterostomia Bilateria Metazoa ZMYM3 HGNC:13054 zinc finger, MYM-type 3 Q14202 Nucleus (By similarity). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12493763,10662551,10662551 nucleus 94 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa ZMYM4 HGNC:13055 zinc finger, MYM-type 4 Q5VZL5 Nucleus (GO:0005634) none,17081983 nucleus 31 0 nucleus nucleus Deuterostomia Bilateria Metazoa ZMYM5 HGNC:13029 zinc finger, MYM-type 5 Q9UJ78 Nucleus (Potential). Nucleus (GO:0005634) nucleus 27 0 nucleus nucleus Theria Tetrapoda Eukaryota ZMYM6 HGNC:13050 zinc finger, MYM-type 6 O95789 Nucleus (Potential). Nucleus (GO:0005634) nucleus 21 0 nucleus nucleus Deuterostomia Bilateria Eukaryota ZMYM6NB HGNC:40021 ZMYM6 neighbor Q8NCS4 Membrane; Multi-pass membrane protein (Potential). golgi apparatus membrane 27 3 golgi apparatus membrane golgi apparatus membrane NA NA Tetrapoda ZMYND10 HGNC:19412 zinc finger, MYND-type containing 10 O75800 Cytoplasm (GO:0005737) 11085536 nucleus 22 0 cytoplasm cytoplasm Deuterostomia Eukaryota Eukaryota ZMYND11 HGNC:16966 zinc finger, MYND-type containing 11 Q15326 Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes. Nucleus (GO:0005634);Nucleus (GO:0005634) 10734313/,17000644,16565076, nucleus 100 0 nucleus nucleus Chordata Bilateria NA ZMYND12 HGNC:21192 zinc finger, MYND-type containing 12 Q9H0C1 nucleus 40 1 nucleus nucleus Deuterostomia Eukaryota Cell.Organisms ZMYND15 HGNC:20997 zinc finger, MYND-type containing 15 Q9H091 Nucleus (By similarity). Cytoplasm (By similarity). nucleus 26 0 nucleus nucleus Theria Eukaryota Eukaryota ZMYND19 HGNC:21146 zinc finger, MYND-type containing 19 Q96E35 Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm (GO:0005737); Plasma membrane (GO:0005886) 12208518,12208518 nucleus 47 0 cytoplasm cytoplasm Chordata Chordata Opisthokonta ZMYND8 HGNC:9397 zinc finger, MYND-type containing 8 Q9ULU4 Nucleus (GO:0005634);Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,none,17081983,16565076,/17081983,17081983 nucleus 30 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota ZNF10 HGNC:12879 zinc finger protein 10 P21506 Nucleus (Probable). Nucleus (GO:0005634) 2288909 nucleus 42 0 nucleus nucleus NA NA Eukaryota ZNF100 HGNC:12880 zinc finger protein 100 Q8IYN0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 66 0 nucleus nucleus Bilateria Bilateria NA ZNF101 HGNC:12881 zinc finger protein 101 Q8IZC7 Nucleus (Probable). Nucleus (GO:0005634) 17081983 nucleus 33 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF106 HGNC:12886 zinc finger protein 106 Q9H2Y7 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) 17000644,17081983 nucleus 8 0 nucleus nucleus Euteleostomi Euteleostomi Cell.Organisms ZNF107 HGNC:12887 zinc finger protein 107 Q9UII5 Nucleus (Potential). nucleus 68 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF112 HGNC:12892 zinc finger protein 112 Q9UJU3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus NA NA Eukaryota ZNF114 HGNC:12894 zinc finger protein 114 Q8NC26 Nucleus (Probable). Nucleus (GO:0005634) nucleus 29 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF117 HGNC:12897 zinc finger protein 117 Q03924 Nucleus (Probable). Nucleus (GO:0005634) 17081983 nucleus 59 0 nucleus nucleus Catarrhini Catarrhini Cell.Organisms ZNF12 HGNC:12902 zinc finger protein 12 P17014 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF121 HGNC:12904 zinc finger protein 121 P58317 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF124 HGNC:12907 zinc finger protein 124 Q15973 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Homininae Homininae Eukaryota ZNF131 HGNC:12915 zinc finger protein 131 P52739 Nucleus. Note=Sumoylation does not affect nuclear localization. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota ZNF132 HGNC:12916 zinc finger protein 132 P52740 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF133 HGNC:12917 zinc finger protein 133 P52736 Nucleus (Potential). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF134 HGNC:12918 zinc finger protein 134 P52741 Nucleus (Potential). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Homininae Eutheria Eukaryota ZNF135 HGNC:12919 zinc finger protein 135 P52742 Nucleus (Potential). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF136 HGNC:12920 zinc finger protein 136 P52737 Nucleus (Potential). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF138 HGNC:12922 zinc finger protein 138 P52744 Nucleus (Potential). Nucleus (GO:0005634) nucleus 55 0 nucleus nucleus Human Human Eukaryota ZNF14 HGNC:12924 zinc finger protein 14 P17017 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF140 HGNC:12925 zinc finger protein 140 P52738 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF141 HGNC:12926 zinc finger protein 141 Q15928 Nucleus (Potential). Nucleus (GO:0005634) 9671765 nucleus 52 0 nucleus nucleus Bilateria Bilateria NA ZNF142 HGNC:12927 zinc finger protein 142 P52746 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 nucleus 20 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF143 HGNC:12928 zinc finger protein 143 P52747 Nucleus (Potential). Nucleus (GO:0005634) 9705341 nucleus 36 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZNF146 HGNC:12931 zinc finger protein 146 Q15072 Nucleus. Nucleus (GO:0005634) 8665923 nucleus 100 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF148 HGNC:12933 zinc finger protein 148 Q9UQR1 Nucleus. Nucleus (GO:0005634) 9144414,17081983 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF154 HGNC:12939 zinc finger protein 154 Q13106 Nucleus (Potential). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Human Eutheria Eukaryota ZNF155 HGNC:12940 zinc finger protein 155 Q12901 Nucleus (Potential). Nucleus (GO:0005634) nucleus 69 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF157 HGNC:12942 zinc finger protein 157 P51786 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF16 HGNC:12947 zinc finger protein 16 P17020 Nucleus (Potential). Nucleus (GO:0005634) 11054286 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF160 HGNC:12948 zinc finger protein 160 Q9HCG1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF165 HGNC:12953 zinc finger protein 165 P49910 Nucleus (Potential). Nucleus (GO:0005634) 9244436 nucleus 45 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF169 HGNC:12957 zinc finger protein 169 Q14929 Nucleus (Potential). Nucleus (GO:0005634) 9071574 nucleus 40 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF17 HGNC:12958 zinc finger protein 17 P17021 Nucleus (Potential). nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF174 HGNC:12963 zinc finger protein 174 Q15697 Nucleus. Nucleus (GO:0005634) 7673192 nucleus 100 0 nucleus nucleus Theria Theria Eukaryota ZNF175 HGNC:12964 zinc finger protein 175 Q9Y473 Cytoplasm. Nucleus. Nucleus (GO:0005634) 8838321 nucleus 46 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ZNF177 HGNC:12966 zinc finger protein 177 Q13360 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus NA NA Eukaryota ZNF18 HGNC:12969 zinc finger protein 18 P17022 Nucleus (Potential). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Mammalia Mammalia Eukaryota ZNF180 HGNC:12970 zinc finger protein 180 Q9UJW8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF181 HGNC:12971 zinc finger protein 181 Q2M3W8 Nucleus (Probable). nucleus 45 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF182 HGNC:13001 zinc finger protein 182 P17025 Nucleus (Potential). nucleus 53 0 nucleus nucleus Catarrhini Eutheria NA ZNF184 HGNC:12975 zinc finger protein 184 Q99676 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF185 HGNC:12976 zinc finger protein 185 (LIM domain) O15231 Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus (GO:0005634) secreted 9 0 cytoplasm cytoplasm Amniota Euteleostomi NA ZNF189 HGNC:12980 zinc finger protein 189 O75820 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF19 HGNC:12981 zinc finger protein 19 P17023 Nucleus (Potential). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF195 HGNC:12986 zinc finger protein 195 O14628 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF197 HGNC:12988 zinc finger protein 197 O14709 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF2 HGNC:12991 zinc finger protein 2 Q9BSG1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF20 HGNC:12992 zinc finger protein 20 P17024 Nucleus (Potential). Nucleus (GO:0005634) 9380504 nucleus 36 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF200 HGNC:12993 zinc finger protein 200 P98182 Nucleus (Probable). Nucleus (GO:0005634) 9787081 nucleus 35 0 nucleus nucleus Theria Theria Eukaryota ZNF202 HGNC:12994 zinc finger protein 202 O95125 Nucleus. Nucleus (GO:0005634) 11279031 nucleus 100 0 nucleus nucleus Mammalia Mammalia Eukaryota ZNF205 HGNC:12996 zinc finger protein 205 O95201 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Theria Theria Eukaryota ZNF207 HGNC:12998 zinc finger protein 207 O43670 Nucleus (Probable). Nucleus (GO:0005634);Nucleus (GO:0005634); Nucleolus (GO:0005730) 9799612/9799612,15635413 cytoplasm 34 0 nucleus nucleus Bilateria Eukaryota Eukaryota ZNF208 HGNC:12999 zinc finger protein 208 O43345 Nucleus (Probable). Nucleus (GO:0005634) 9724325 nucleus 63 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF211 HGNC:13003 zinc finger protein 211 Q13398 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF212 HGNC:13004 zinc finger protein 212 Q9UDV6 Nucleus (Potential). Nucleus (GO:0005634) 9169157 nucleus 24 0 nucleus nucleus Theria Theria Eukaryota ZNF213 HGNC:13005 zinc finger protein 213 O14771 Nucleus (Potential). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF214 HGNC:13006 zinc finger protein 214 Q9UL59 Nucleus (Probable). Nucleus (GO:0005634) 7959730 nucleus 50 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF215 HGNC:13007 zinc finger protein 215 Q9UL58 Nucleus (Probable). Nucleus (GO:0005634) 7959730 nucleus 31 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF217 HGNC:13009 zinc finger protein 217 O75362 Nucleus (Probable). Nucleus (GO:0005634) 9671742 nucleus 12 0 nucleus nucleus Human Euteleostomi Eukaryota ZNF219 HGNC:13011 zinc finger protein 219 Q9P2Y4 Nucleus. Nucleus (GO:0005634) 10819330,17081983 nucleus 100 0 nucleus nucleus Mammalia Chordata Eukaryota ZNF22 HGNC:13012 zinc finger protein 22 P17026 Nucleus (By similarity). Nucleus (GO:0005634) 1946370 nucleus 83 0 nucleus nucleus Theria Theria Eukaryota ZNF221 HGNC:13014 zinc finger protein 221 Q9UK13 Nucleus (Probable). Nucleus (GO:0005634) nucleus 74 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF222 HGNC:13015 zinc finger protein 222 Q9UK12 Nucleus (Probable). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF223 HGNC:13016 zinc finger protein 223 Q9UK11 Nucleus (Probable). Nucleus (GO:0005634) nucleus 57 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF224 HGNC:13017 zinc finger protein 224 Q9NZL3 Nucleus. Note=Co-localizes with DEPDC1A at the nucleus. Nucleus (GO:0005634) 12239212 nucleus 100 0 nucleus nucleus Bilateria Bilateria NA ZNF225 HGNC:13018 zinc finger protein 225 Q9UK10 Nucleus (Probable). Nucleus (GO:0005634) nucleus 62 0 nucleus nucleus NA NA Eukaryota ZNF226 HGNC:13019 zinc finger protein 226 Q9NYT6 Nucleus (Probable). Nucleus (GO:0005634) 12743021 nucleus 49 0 nucleus nucleus NA NA Eukaryota ZNF227 HGNC:13020 zinc finger protein 227 Q86WZ6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF229 HGNC:13022 zinc finger protein 229 Q9UJW7 Nucleus (Probable). nucleus 50 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF23 HGNC:13023 zinc finger protein 23 P17027 Nucleus (Potential). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF230 HGNC:13024 zinc finger protein 230 Q9UIE0 Nucleus (Probable). Nucleus (GO:0005634) 15640038,11672448 nucleus 44 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF232 HGNC:13026 zinc finger protein 232 Q9UNY5 Nucleus. Nucleus (GO:0005634) 11311944 nucleus 100 0 nucleus nucleus Homininae Homininae Eukaryota ZNF233 HGNC:30946 zinc finger protein 233 A6NK53 Nucleus (Probable). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF234 HGNC:13027 zinc finger protein 234 Q14588 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus NA NA Eukaryota ZNF235 HGNC:12866 zinc finger protein 235 Q14590 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF236 HGNC:13028 zinc finger protein 236 Q9UL36 Nucleus (Probable). Nucleus (GO:0005634) nucleus 26 0 nucleus nucleus Theria Chordata Eukaryota ZNF239 HGNC:13031 zinc finger protein 239 Q16600 Nucleus (Potential). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 9121460,17081983 nucleus 51 0 cytoplasm. nucleus multiple Catarrhini Eutheria Eukaryota ZNF24 HGNC:13032 zinc finger protein 24 P17028 Nucleus. Nucleus (GO:0005634) 2288909 nucleus 100 0 nucleus nucleus Theria Theria Eukaryota ZNF248 HGNC:13041 zinc finger protein 248 Q8NDW4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF25 HGNC:13043 zinc finger protein 25 P17030 Nucleus (Potential). Nucleus (GO:0005634) 21665855 nucleus 48 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF250 HGNC:13044 zinc finger protein 250 P15622 Nucleus (Probable). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF251 HGNC:13045 zinc finger protein 251 Q9BRH9 Nucleus (Probable). nucleus 48 0 nucleus nucleus Euarchontoglires Euarchontoglires Cell.Organisms ZNF253 HGNC:13497 zinc finger protein 253 O75346 Nucleus (Probable). Nucleus (GO:0005634) 10585455 nucleus 59 0 nucleus nucleus NA NA Eukaryota ZNF254 HGNC:13047 zinc finger protein 254 O75437 Nucleus (Probable). Nucleus (GO:0005634) nucleus 67 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF256 HGNC:13049 zinc finger protein 256 Q9Y2P7 Nucleus. Nucleus (GO:0005634) 10585455 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF257 HGNC:13498 zinc finger protein 257 Q9Y2Q1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 64 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF26 HGNC:13053 zinc finger protein 26 P17031 Nucleus (Potential). Nucleus (GO:0005634) 2026422 nucleus 47 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF260 HGNC:13499 zinc finger protein 260 Q3ZCT1 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus NA NA Eukaryota ZNF263 HGNC:13056 zinc finger protein 263 O14978 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Mammalia Mammalia Eukaryota ZNF264 HGNC:13057 zinc finger protein 264 O43296 Nucleus (Probable). Nucleus (GO:0005634) 9455477 nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF266 HGNC:13059 zinc finger protein 266 Q14584 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Homininae Homininae Eukaryota ZNF267 HGNC:13060 zinc finger protein 267 Q14586 Nucleus (Probable). Nucleus (GO:0005634) none,17081983 nucleus 47 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF268 HGNC:13061 zinc finger protein 268 Q14587 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF273 HGNC:13067 zinc finger protein 273 Q14593 Nucleus (Probable). Nucleus (GO:0005634) nucleus 66 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF274 HGNC:13068 zinc finger protein 274 Q96GC6 Cytoplasm (By similarity). Nucleus, nucleolus. Nucleolus (GO:0005730) 10777669 nucleus 40 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF275 HGNC:13069 zinc finger protein 275 Q9NSD4 Nucleus (Probable). Nucleus (GO:0005634) 16606702,14519192,17098717 nucleus 43 0 nucleus nucleus Theria Theria NA ZNF276 HGNC:23330 zinc finger protein 276 Q8N554 Nucleus (Potential). Nucleus (GO:0005634) nucleus 19 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF277 HGNC:13070 zinc finger protein 277 Q9NRM2 Nucleus (Potential). Nucleus (GO:0005634) 10860669 cytoplasm 20 0 nucleus nucleus Bilateria Eukaryota Eukaryota ZNF28 HGNC:13073 zinc finger protein 28 P17035 Nucleus (Potential). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF280A HGNC:18597 zinc finger protein 280A P59817 Nucleus (Potential). Nucleus (GO:0005634) nucleus 14 0 nucleus nucleus Eutheria Eutheria Opisthokonta ZNF280B HGNC:23022 zinc finger protein 280B Q86YH2 Nucleus (Potential). Nucleus (GO:0005634) nucleus 14 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF280C HGNC:25955 zinc finger protein 280C Q8ND82 Nucleus (Potential). Nucleus (GO:0005634) nucleus 12 0 nucleus nucleus Tetrapoda Euteleostomi Opisthokonta ZNF280D HGNC:25953 zinc finger protein 280D Q6N043 Nucleus (Potential). Nucleus (GO:0005634) nucleus 13 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZNF281 HGNC:13075 zinc finger protein 281 Q9Y2X9 Nucleus. Nucleus (GO:0005634) 10405178 nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF282 HGNC:13076 zinc finger protein 282 Q9UDV7 Nucleus (Probable). Nucleus (GO:0005634) 9396811 nucleus 38 0 nucleus nucleus Amniota Amniota Eukaryota ZNF283 HGNC:13077 zinc finger protein 283 Q8N7M2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Human Eutheria Cell.Organisms ZNF284 HGNC:13078 zinc finger protein 284 Q2VY69 Nucleus (Probable). nucleus 60 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF285 HGNC:13079 zinc finger protein 285 Q96NJ3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus NA NA NA ZNF286A HGNC:13501 zinc finger protein 286A Q9HBT8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus Theria Theria Eukaryota ZNF286B HGNC:33241 zinc finger protein 286B P0CG31 Nucleus (Probable). nucleus 52 0 nucleus nucleus NA NA Eukaryota ZNF287 HGNC:13502 zinc finger protein 287 Q9HBT7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Euarchontoglires Theria Eukaryota ZNF292 HGNC:18410 zinc finger protein 292 O60281 Nucleus (Probable). Nucleus (GO:0005634) 16303260,10687855 nucleus 8 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF296 HGNC:15981 zinc finger protein 296 Q8WUU4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 10 0 nucleus nucleus Theria Theria Eukaryota ZNF3 HGNC:13089 zinc finger protein 3 P17036 Nucleus (Potential). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Theria Theria Eukaryota ZNF30 HGNC:13090 zinc finger protein 30 P17039 Nucleus (Potential). nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF300 HGNC:13091 zinc finger protein 300 Q96RE9 Nucleus. Nucleus (GO:0005634) 14746915 nucleus 100 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF302 HGNC:13848 zinc finger protein 302 Q9NR11 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF304 HGNC:13505 zinc finger protein 304 Q9HCX3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 54 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF311 HGNC:13847 zinc finger protein 311 Q5JNZ3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Eutheria NA ZNF317 HGNC:13507 zinc finger protein 317 Q96PQ6 Nucleus (Probable). Nucleus (GO:0005634) 11688974 nucleus 37 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF318 HGNC:13578 zinc finger protein 318 Q5VUA4 Nucleus. Nucleus (GO:0005634) 10873617,17081983 nucleus 100 0 nucleus nucleus Deuterostomia Bilateria Eumetazoa ZNF319 HGNC:13644 zinc finger protein 319 Q9P2F9 Nucleus (Probable). Nucleus (GO:0005634) 11161788 nucleus 27 0 nucleus nucleus Amniota Euteleostomi Eukaryota ZNF32 HGNC:13095 zinc finger protein 32 P17041 Nucleus (Potential). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF320 HGNC:13842 zinc finger protein 320 A2RRD8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Human Human Eukaryota ZNF322 HGNC:23640 zinc finger protein 322 Q6U7Q0 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15555580,15555580 nucleus 48 0 cytoplasm. nucleus multiple Euarchontoglires Eutheria NA ZNF324 HGNC:14096 zinc finger protein 324 O75467 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF324B HGNC:33107 zinc finger protein 324B Q6AW86 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus NA NA Eukaryota ZNF326 HGNC:14104 zinc finger protein 326 Q5BKZ1 Nucleus matrix (By similarity). Nucleolus (GO:0005730) 15635413 nucleus 92 0 nucleus nucleus Tetrapoda Euteleostomi Craniata ZNF329 HGNC:14209 zinc finger protein 329 Q86UD4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF330 HGNC:15462 zinc finger protein 330 Q9Y3S2 Nucleus. Nucleus, nucleolus. Chromosome, centromere. Note=Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 11528117,10593942,11528117,10593942,11528117,10593942 nucleus 100 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Metazoa ZNF331 HGNC:15489 zinc finger protein 331 Q9NQX6 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF333 HGNC:15624 zinc finger protein 333 Q96JL9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Human Eutheria Eukaryota ZNF334 HGNC:15806 zinc finger protein 334 Q9HCZ1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF335 HGNC:15807 zinc finger protein 335 Q9H4Z2 Nucleus. Nucleus (GO:0005634) 12215545 nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF337 HGNC:15809 zinc finger protein 337 Q9Y3M9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF33A HGNC:13096 zinc finger protein 33A Q06730 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF33B HGNC:13097 zinc finger protein 33B Q06732 Nucleus (Potential). nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF34 HGNC:13098 zinc finger protein 34 Q8IZ26 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF341 HGNC:15992 zinc finger protein 341 Q9BYN7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Chordata Chordata Eukaryota ZNF343 HGNC:16017 zinc finger protein 343 Q6P1L6 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Human Human Eukaryota ZNF345 HGNC:16367 zinc finger protein 345 Q14585 Nucleus (Probable). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus NA NA Cell.Organisms ZNF346 HGNC:16403 zinc finger protein 346 Q9UL40 Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5. Nucleolus (GO:0005730); Nucleus (GO:0005634); Cytoplasm (GO:0005737) 10488071,15254228,15254228 nucleus 12 0 cytoplasm. nucleus multiple Euteleostomi Eukaryota Eumetazoa ZNF347 HGNC:16447 zinc finger protein 347 Q96SE7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF35 HGNC:13099 zinc finger protein 35 P13682 Nucleus (Potential). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF350 HGNC:16656 zinc finger protein 350 Q9GZX5 Nucleus matrix. Note=Associated with the nuclear matrix. Nucleus (GO:0005634) 11161714,11090615 nucleus 100 0 nucleus nucleus NA NA Eukaryota ZNF354A HGNC:11628 zinc finger protein 354A O60765 Nucleus (By similarity). Nucleus (GO:0005634) 8382778 nucleus 84 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF354B HGNC:17197 zinc finger protein 354B Q96LW1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 77 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF354C HGNC:16736 zinc finger protein 354C Q86Y25 Nucleus. Nucleus (GO:0005634) 15555547 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF358 HGNC:16838 zinc finger protein 358 Q9NW07 Nucleus (Probable). Nucleus (GO:0005634) 12036583 nucleus 42 1 nucleus nucleus Euarchontoglires Eukaryota Eukaryota ZNF362 HGNC:18079 zinc finger protein 362 Q5T0B9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 31 0 nucleus nucleus Theria Deuterostomia Eukaryota ZNF365 HGNC:18194 zinc finger protein 365 Q70YC4 Centrosome (GO:0005813);Integral to membrane (GO:0016021) 16682949/12740763 secreted 38 0 secreted secreted Tetrapoda Chordata Deuterostomia ZNF366 HGNC:18316 zinc finger protein 366 Q8N895 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Amniota Euteleostomi Eukaryota ZNF367 HGNC:18320 zinc finger protein 367 Q7RTV3 Nucleus. Nucleus (GO:0005634) 15344908 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ZNF37A HGNC:13102 zinc finger protein 37A P17032 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF382 HGNC:17409 zinc finger protein 382 Q96SR6 Nucleus (By similarity). Nucleus (GO:0005634) 12459182 nucleus 71 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF383 HGNC:18609 zinc finger protein 383 Q8NA42 Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions. Nucleus (GO:0005634) nucleus 53 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ZNF384 HGNC:11955 zinc finger protein 384 Q8TF68 Nucleus (By similarity). Nucleus (GO:0005634) 12359745,19059367 nucleus 90 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF385A HGNC:17521 zinc finger protein 385A Q96PM9 Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite (By similarity). Note=Detected in dendrites of Purkinje cells and hippocampal neurons (By similarity). Nucleolus (GO:0005730); Cytoplasm (GO:0005737) 15527981,15527981 nucleus 40 0 cytoplasm. nucleus multiple Euarchontoglires Euteleostomi Eukaryota ZNF385B HGNC:26332 zinc finger protein 385B Q569K4 Nucleus. nucleus 100 0 nucleus nucleus Chordata Eukaryota Eukaryota ZNF385C HGNC:33722 zinc finger protein 385C Q66K41 Nucleus (By similarity). nucleus 35 0 nucleus nucleus Euteleostomi Euteleostomi NA ZNF385D HGNC:26191 zinc finger protein 385D Q9H6B1 Nucleus (Potential). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Chordata Eukaryota Eukaryota ZNF391 HGNC:18779 zinc finger protein 391 Q9UJN7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF394 HGNC:18832 zinc finger protein 394 Q53GI3 Nucleus (Potential). Nucleus (GO:0005634) 15249231 nucleus 36 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF395 HGNC:18737 zinc finger protein 395 Q9H8N7 Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm. Nucleus (GO:0005634) nucleus 65 0 cytoplasm. nucleus multiple Chordata Bilateria Eumetazoa ZNF396 HGNC:18824 zinc finger protein 396 Q96N95 Isoform 1: Nucleus. Isoform 2: Nucleus. Cytoplasm. Nucleus (GO:0005634) 12801647 nucleus 38 0 cytoplasm. nucleus multiple Homininae Theria Eukaryota ZNF397 HGNC:18818 zinc finger protein 397 Q8NF99 Isoform 1: Nucleus. Isoform 3: Nucleus. Cytoplasm. Nucleus (GO:0005634) 12801647 nucleus 48 0 cytoplasm. nucleus multiple Eutheria Mammalia Eukaryota ZNF398 HGNC:18373 zinc finger protein 398 Q8TD17 Nucleus (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11779858,11779858 nucleus 30 0 cytoplasm. nucleus multiple Theria Theria Eukaryota ZNF404 HGNC:19417 zinc finger protein 404 Q494X3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Homininae Eutheria Eukaryota ZNF407 HGNC:19904 zinc finger protein 407 Q9C0G0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 27 0 nucleus nucleus Deuterostomia Deuterostomia Eukaryota ZNF408 HGNC:20041 zinc finger protein 408 Q9H9D4 Nucleus (Potential). Nucleus (GO:0005634) nucleus 23 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF41 HGNC:13107 zinc finger protein 41 P51814 Nucleus (Potential). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF410 HGNC:20144 zinc finger protein 410 Q86VK4 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 12370286,12370286 nucleus 31 0 cytoplasm. nucleus multiple Euteleostomi Deuterostomia Eukaryota ZNF414 HGNC:20630 zinc finger protein 414 Q96IQ9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 20 0 nucleus nucleus Amniota Euteleostomi Opisthokonta ZNF415 HGNC:20636 zinc finger protein 415 Q09FC8 Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus. Nucleus (GO:0005634) nucleus 52 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ZNF416 HGNC:20645 zinc finger protein 416 Q9BWM5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF417 HGNC:20646 zinc finger protein 417 Q8TAU3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF418 HGNC:20647 zinc finger protein 418 Q8TF45 Nucleus (Probable). nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF419 HGNC:20648 zinc finger protein 419 Q96HQ0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF420 HGNC:20649 zinc finger protein 420 Q8TAQ5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF423 HGNC:16762 zinc finger protein 423 Q2M1K9 Nucleus. Nucleus (GO:0005634) 10660046,14623329 nucleus 100 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ZNF425 HGNC:20690 zinc finger protein 425 Q6IV72 Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus. Nucleus (GO:0005634) nucleus 31 0 cytoplasm. nucleus multiple Catarrhini Theria Eukaryota ZNF426 HGNC:20725 zinc finger protein 426 Q9BUY5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF428 HGNC:20804 zinc finger protein 428 Q96B54 Nucleus (GO:0005634) secreted 44 0 secreted secreted Theria Theria Mammalia ZNF429 HGNC:20817 zinc finger protein 429 Q86V71 Nucleus (Potential). Nucleus (GO:0005634) nucleus 65 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF43 HGNC:13109 zinc finger protein 43 P17038 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 66 0 nucleus nucleus Bilateria Bilateria NA ZNF430 HGNC:20808 zinc finger protein 430 Q9H8G1 Nucleus (Potential). Nucleus (GO:0005634) nucleus 67 0 nucleus nucleus Bilateria Bilateria NA ZNF431 HGNC:20809 zinc finger protein 431 Q8TF32 Nucleus (Potential). Nucleus (GO:0005634) nucleus 65 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF432 HGNC:20810 zinc finger protein 432 O94892 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus NA NA Cell.Organisms ZNF433 HGNC:20811 zinc finger protein 433 Q8N7K0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF436 HGNC:20814 zinc finger protein 436 Q9C0F3 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Mammalia Tetrapoda Eukaryota ZNF438 HGNC:21029 zinc finger protein 438 Q7Z4V0 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF439 HGNC:20873 zinc finger protein 439 Q8NDP4 Nucleus (Potential). nucleus 39 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF44 HGNC:13110 zinc finger protein 44 P15621 Nucleus (Probable). Nucleus (GO:0005634) 1946370 nucleus 39 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF440 HGNC:20874 zinc finger protein 440 Q8IYI8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF441 HGNC:20875 zinc finger protein 441 Q8N8Z8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF442 HGNC:20877 zinc finger protein 442 Q9H7R0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF443 HGNC:20878 zinc finger protein 443 Q9Y2A4 Nucleus (Potential). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF444 HGNC:16052 zinc finger protein 444 Q8N0Y2 Nucleus (Potential). Nucleus (GO:0005634) 11978792 nucleus 25 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF445 HGNC:21018 zinc finger protein 445 P59923 Nucleus (Potential). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF446 HGNC:21036 zinc finger protein 446 Q9NWS9 Nucleus (Potential). Nucleus (GO:0005634) 15936718 nucleus 20 0 nucleus nucleus Catarrhini Eutheria Opisthokonta ZNF449 HGNC:21039 zinc finger protein 449 Q6P9G9 Nucleus (Potential). Nucleus (GO:0005634) 16636917 nucleus 38 0 nucleus nucleus Eutheria Eutheria NA ZNF45 HGNC:13111 zinc finger protein 45 Q02386 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF451 HGNC:21091 zinc finger protein 451 Q9Y4E5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 13 0 nucleus nucleus Tetrapoda Euteleostomi Holozoa ZNF454 HGNC:21200 zinc finger protein 454 Q8N9F8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Euarchontoglires Eukaryota ZNF460 HGNC:21628 zinc finger protein 460 Q14592 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF461 HGNC:21629 zinc finger protein 461 Q8TAF7 Nucleus (Probable). nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF462 HGNC:21684 zinc finger protein 462 Q96JM2 Nucleus (Potential). Nucleus (GO:0005634) ,17000644 nucleus 10 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF467 HGNC:23154 zinc finger protein 467 Q7Z7K2 Nucleus (By similarity). Nucleus (GO:0005634) 12426389 nucleus 81 0 nucleus nucleus Theria Amniota Eukaryota ZNF468 HGNC:33105 zinc finger protein 468 Q5VIY5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF469 HGNC:23216 zinc finger protein 469 Q96JG9 Nucleus (Potential). nucleus 16 0 nucleus nucleus NA NA Eumetazoa ZNF470 HGNC:22220 zinc finger protein 470 Q6ECI4 Nucleus. Nucleus (GO:0005634) 15302581 nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF471 HGNC:23226 zinc finger protein 471 Q9BX82 Nucleus (Potential). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF473 HGNC:23239 zinc finger protein 473 Q8WTR7 Nucleus. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA. Nucleus (GO:0005634) 11782445 nucleus 100 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF474 HGNC:23245 zinc finger protein 474 Q6S9Z5 Nucleus (GO:0005634) nucleus 83 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ZNF479 HGNC:23258 zinc finger protein 479 Q96JC4 Nucleus (Potential). Nucleus (GO:0005634) nucleus 61 0 nucleus nucleus Bilateria Bilateria NA ZNF48 HGNC:13114 zinc finger protein 48 Q96MX3 Nucleus (Probable). nucleus 31 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF480 HGNC:23305 zinc finger protein 480 Q8WV37 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF483 HGNC:23384 zinc finger protein 483 Q8TF39 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Homininae Euarchontoglires Eukaryota ZNF484 HGNC:23385 zinc finger protein 484 Q5JVG2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF485 HGNC:23440 zinc finger protein 485 Q8NCK3 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF486 HGNC:20807 zinc finger protein 486 Q96H40 Nucleus (Potential). nucleus 62 0 nucleus nucleus NA NA NA ZNF488 HGNC:23535 zinc finger protein 488 Q96MN9 Nucleus (Potential). nucleus 30 0 nucleus nucleus Amniota Bilateria NA ZNF490 HGNC:23705 zinc finger protein 490 Q9ULM2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF491 HGNC:23706 zinc finger protein 491 Q8N8L2 Nucleus (Potential). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Human Human Eukaryota ZNF492 HGNC:23707 zinc finger protein 492 Q9P255 Nucleus (Probable). Nucleus (GO:0005634) 16714237 nucleus 61 0 nucleus nucleus NA NA Cell.Organisms ZNF493 HGNC:23708 zinc finger protein 493 Q6ZR52 Nucleus (Potential). Nucleus (GO:0005634) nucleus 64 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF496 HGNC:23713 zinc finger protein 496 Q96IT1 Nucleus (By similarity). Nucleus (GO:0005634) 15169884 nucleus 71 0 nucleus nucleus Theria Theria Eukaryota ZNF497 HGNC:23714 zinc finger protein 497 Q6ZNH5 Nucleus (Potential). nucleus 46 0 nucleus nucleus Human Catarrhini Cell.Organisms ZNF500 HGNC:23716 zinc finger protein 500 O60304 Nucleus (Potential). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Theria Theria Eukaryota ZNF501 HGNC:23717 zinc finger protein 501 Q96CX3 Nucleus (Potential). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Human Human Eukaryota ZNF502 HGNC:23718 zinc finger protein 502 Q8TBZ5 Nucleus (Potential). nucleus 52 0 nucleus nucleus Homininae Eutheria Eukaryota ZNF503 HGNC:23589 zinc finger protein 503 Q96F45 Nucleus (By similarity). Cytoplasm (GO:0005737) 17081983 nucleus 78 0 cytoplasm cytoplasm Deuterostomia Deuterostomia Bilateria ZNF506 HGNC:23780 zinc finger protein 506 Q5JVG8 Nucleus (Potential). Nucleolus (GO:0005730) 11256614 nucleus 57 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF507 HGNC:23783 zinc finger protein 507 Q8TCN5 Nucleus (Potential). nucleus 7 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta ZNF510 HGNC:29161 zinc finger protein 510 Q9Y2H8 Nucleus (Probable). nucleus 46 0 nucleus nucleus Homininae Homininae Eukaryota ZNF511 HGNC:28445 zinc finger protein 511 Q8NB15 Nucleus (Potential). nucleus 20 1 nucleus nucleus Amniota Eukaryota Eukaryota ZNF512 HGNC:29380 zinc finger protein 512 Q96ME7 Nucleus (Potential). Nucleus (GO:0005634) nucleus 11 0 nucleus nucleus NA NA Metazoa ZNF512B HGNC:29212 zinc finger protein 512B Q96KM6 Nucleus (Probable). Nucleus (GO:0005634) 10574462,15561729 nucleus 21 0 nucleus nucleus Amniota Euteleostomi Eukaryota ZNF513 HGNC:26498 zinc finger protein 513 Q8N8E2 Nucleus. nucleus 100 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF514 HGNC:25894 zinc finger protein 514 Q96K75 Nucleus (Potential). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF516 HGNC:28990 zinc finger protein 516 Q92618 Nucleus (Probable). Nucleus (GO:0005634) nucleus 22 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF517 HGNC:27984 zinc finger protein 517 Q6ZMY9 Nucleus (Potential). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF518A HGNC:29009 zinc finger protein 518A Q6AHZ1 Nucleus (Probable). Nucleus (GO:0005634) 17081983 nucleus 13 0 nucleus nucleus Tetrapoda Euteleostomi NA ZNF518B HGNC:29365 zinc finger protein 518B Q9C0D4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 24 0 nucleus nucleus Tetrapoda Tetrapoda Opisthokonta ZNF519 HGNC:30574 zinc finger protein 519 Q8TB69 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Homininae Homininae Cell.Organisms ZNF521 HGNC:24605 zinc finger protein 521 Q96K83 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 97 0 nucleus nucleus Euteleostomi Bilateria Eukaryota ZNF524 HGNC:28322 zinc finger protein 524 Q96C55 Nucleus (Probable). Nucleus (GO:0005634) nucleus 24 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF525 HGNC:29423 zinc finger protein 525 Q8N782 Nucleus (Potential). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Human Human Eukaryota ZNF526 HGNC:29415 zinc finger protein 526 Q8TF50 Nucleus (Probable). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Theria Theria Eukaryota ZNF527 HGNC:29385 zinc finger protein 527 Q8NB42 Nucleus (Potential). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Human Eutheria Eukaryota ZNF528 HGNC:29384 zinc finger protein 528 Q3MIS6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 55 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF529 HGNC:29328 zinc finger protein 529 Q6P280 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF530 HGNC:29297 zinc finger protein 530 Q6P9A1 Nucleus (Probable). nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF532 HGNC:30940 zinc finger protein 532 Q9HCE3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 8 0 nucleus nucleus Chordata Chordata Eukaryota ZNF534 HGNC:26337 zinc finger protein 534 Q76KX8 Nucleus (Probable). nucleus 58 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF536 HGNC:29025 zinc finger protein 536 O15090 Nucleus (Probable). Nucleus (GO:0005634) nucleus 14 1 nucleus nucleus Amniota Euteleostomi Eukaryota ZNF540 HGNC:25331 zinc finger protein 540 Q8NDQ6 Nucleus. Cytoplasm. Nucleus (GO:0005634) nucleus 44 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ZNF541 HGNC:25294 zinc finger protein 541 Q9H0D2 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 71 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF543 HGNC:25281 zinc finger protein 543 Q08ER8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF544 HGNC:16759 zinc finger protein 544 Q6NX49 Nucleus (Potential). nucleus 51 0 nucleus nucleus Human Human Eukaryota ZNF546 HGNC:28671 zinc finger protein 546 Q86UE3 Nucleus (Probable). nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF547 HGNC:26432 zinc finger protein 547 Q8IVP9 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF548 HGNC:26561 zinc finger protein 548 Q8NEK5 Nucleus (Probable). nucleus 42 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF549 HGNC:26632 zinc finger protein 549 Q6P9A3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 38 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF550 HGNC:28643 zinc finger protein 550 Q7Z398 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF551 HGNC:25108 zinc finger protein 551 Q7Z340 Nucleus (Probable). nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF552 HGNC:26135 zinc finger protein 552 Q9H707 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF554 HGNC:26629 zinc finger protein 554 Q86TJ5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF555 HGNC:28382 zinc finger protein 555 Q8NEP9 Nucleus (Probable). nucleus 44 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF556 HGNC:25669 zinc finger protein 556 Q9HAH1 Nucleus (Probable). nucleus 28 0 nucleus nucleus Homininae Homininae Eukaryota ZNF557 HGNC:28632 zinc finger protein 557 Q8N988 Nucleus (Potential). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF558 HGNC:26422 zinc finger protein 558 Q96NG5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Eutheria NA ZNF559 HGNC:28197 zinc finger protein 559 Q9BR84 Nucleus (Potential). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF560 HGNC:26484 zinc finger protein 560 Q96MR9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF561 HGNC:28684 zinc finger protein 561 Q8N587 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF562 HGNC:25950 zinc finger protein 562 Q6V9R5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF563 HGNC:30498 zinc finger protein 563 Q8TA94 Nucleus (Potential). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF564 HGNC:31106 zinc finger protein 564 Q8TBZ8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus NA NA Eukaryota ZNF565 HGNC:26726 zinc finger protein 565 Q8N9K5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Homininae Theria Eukaryota ZNF566 HGNC:25919 zinc finger protein 566 Q969W8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF567 HGNC:28696 zinc finger protein 567 Q8N184 Nucleus (Potential). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF568 HGNC:25392 zinc finger protein 568 Q3ZCX4 Nucleus (Probable). nucleus 50 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF569 HGNC:24737 zinc finger protein 569 Q5MCW4 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 58 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF57 HGNC:13125 zinc finger protein 57 Q68EA5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF570 HGNC:26416 zinc finger protein 570 Q96NI8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF571 HGNC:25000 zinc finger protein 571 Q7Z3V5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF572 HGNC:26758 zinc finger protein 572 Q7Z3I7 Nucleus (Probable). nucleus 41 0 nucleus nucleus Theria Theria Eukaryota ZNF573 HGNC:26420 zinc finger protein 573 Q86YE8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF574 HGNC:26166 zinc finger protein 574 Q6ZN55 Nucleus (Probable). Nucleus (GO:0005634) nucleus 29 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF575 HGNC:27606 zinc finger protein 575 Q86XF7 Nucleus (Potential). Nucleus (GO:0005634) nucleus 26 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF576 HGNC:28357 zinc finger protein 576 Q9H609 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 nucleus 20 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF577 HGNC:28673 zinc finger protein 577 Q9BSK1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF578 HGNC:26449 zinc finger protein 578 Q96N58 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus NA NA Eukaryota ZNF579 HGNC:26646 zinc finger protein 579 Q8NAF0 Nucleus (Potential). Nucleus (GO:0005634) none,17081983 nucleus 14 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF580 HGNC:29473 zinc finger protein 580 Q9UK33 Nucleus (Probable). nucleus 26 0 nucleus nucleus Homininae Theria Eukaryota ZNF581 HGNC:25017 zinc finger protein 581 Q9P0T4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 21 0 nucleus nucleus Catarrhini Theria Eukaryota ZNF582 HGNC:26421 zinc finger protein 582 Q96NG8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Catarrhini Eukaryota Eukaryota ZNF583 HGNC:26427 zinc finger protein 583 Q96ND8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 54 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF584 HGNC:27318 zinc finger protein 584 Q8IVC4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF585A HGNC:26305 zinc finger protein 585A Q6P3V2 Nucleus (Potential). nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF585B HGNC:30948 zinc finger protein 585B Q52M93 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus NA NA Eukaryota ZNF586 HGNC:25949 zinc finger protein 586 Q9NXT0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Human Human Eukaryota ZNF587 HGNC:30955 zinc finger protein 587 Q96SQ5 Nucleus (Probable). Nucleus (GO:0005634) 10520746 nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF587B HGNC:37142 zinc finger protein 587B E7ETH6 Nucleus (Probable). nucleus 41 0 nucleus nucleus NA NA NA ZNF589 HGNC:16747 zinc finger protein 589 Q86UQ0 Nucleus (Potential). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF592 HGNC:28986 zinc finger protein 592 Q92610 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) none,17081983,17081983 nucleus 8 0 cytoplasm. nucleus multiple Chordata Chordata Metazoa ZNF593 HGNC:30943 zinc finger protein 593 O00488 Nucleus, nucleolus. Nucleus (GO:0005634) 17081983 nucleus 100 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ZNF594 HGNC:29392 zinc finger protein 594 Q96JF6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF595 HGNC:27196 zinc finger protein 595 Q8IYB9 Nucleus (Probable). nucleus 61 0 nucleus nucleus Bilateria Bilateria Tetrapoda ZNF596 HGNC:27268 zinc finger protein 596 Q8TC21 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF597 HGNC:26573 zinc finger protein 597 Q96LX8 Nucleus (Potential). nucleus 25 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF598 HGNC:28079 zinc finger protein 598 Q86UK7 Nucleus (GO:0005634) 17081983 nucleus 21 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ZNF599 HGNC:26408 zinc finger protein 599 Q96NL3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF600 HGNC:30951 zinc finger protein 600 Q6ZNG1 Nucleus (Probable). Nucleus (GO:0005634) 12576331 nucleus 44 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF605 HGNC:28068 zinc finger protein 605 Q86T29 Nucleus (Probable). nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF606 HGNC:25879 zinc finger protein 606 Q8WXB4 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF607 HGNC:28192 zinc finger protein 607 Q96SK3 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF608 HGNC:29238 zinc finger protein 608 Q9ULD9 nucleus 96 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta ZNF609 HGNC:29003 zinc finger protein 609 O15014 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983 nucleus 94 0 cytoplasm. nucleus multiple Euteleostomi Euteleostomi Metazoa ZNF610 HGNC:26687 zinc finger protein 610 Q8N9Z0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 58 0 nucleus nucleus Homininae Homininae Eukaryota ZNF611 HGNC:28766 zinc finger protein 611 Q8N823 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF613 HGNC:25827 zinc finger protein 613 Q6PF04 Nucleus (Probable). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF614 HGNC:24722 zinc finger protein 614 Q8N883 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF615 HGNC:24740 zinc finger protein 615 Q8N8J6 Nucleus (Potential). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF616 HGNC:28062 zinc finger protein 616 Q08AN1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF618 HGNC:29416 zinc finger protein 618 Q5T7W0 Nucleus (Probable). nucleus 11 1 nucleus nucleus Tetrapoda Euteleostomi Metazoa ZNF619 HGNC:26910 zinc finger protein 619 Q8N2I2 Nucleus (Probable). nucleus 46 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF620 HGNC:28742 zinc finger protein 620 Q6ZNG0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF621 HGNC:24787 zinc finger protein 621 Q6ZSS3 Nucleus (Potential). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Homininae Eutheria Eukaryota ZNF622 HGNC:30958 zinc finger protein 622 Q969S3 Cytoplasm. Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 12645566,11802789,15561729,11802789,15635413 cytoplasm 19 0 cytoplasm. nucleus multiple Eukaryota Eukaryota Eukaryota ZNF623 HGNC:29084 zinc finger protein 623 O75123 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF624 HGNC:29254 zinc finger protein 624 Q9P2J8 Nucleus (Probable). nucleus 44 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF625 HGNC:30571 zinc finger protein 625 Q96I27 Nucleus (Probable). nucleus 41 0 nucleus nucleus Human Catarrhini Eukaryota ZNF626 HGNC:30461 zinc finger protein 626 Q68DY1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 59 0 nucleus nucleus Bilateria Bilateria NA ZNF627 HGNC:30570 zinc finger protein 627 Q7L945 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF628 HGNC:28054 zinc finger protein 628 Q5EBL2 Nucleus (By similarity). Nucleus (GO:0005634) 15556296 nucleus 72 0 nucleus nucleus Homininae Euteleostomi Eukaryota ZNF629 HGNC:29008 zinc finger protein 629 Q9UEG4 Nucleus (Probable). nucleus 48 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota ZNF630 HGNC:28855 zinc finger protein 630 Q2M218 Nucleus (Probable). nucleus 54 0 nucleus nucleus NA NA NA ZNF638 HGNC:17894 zinc finger protein 638 Q14966 Nucleus speckle. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nuclear matrix (GO:0016363); Nucleoplasm (GO:0005654); Cytoplasm (GO:0005737) 11813260,17081983,11813260,17081983/8647861,8647861,8647861 nucleus 100 0 cytoplasm. nucleus multiple Tetrapoda Tetrapoda Eumetazoa ZNF639 HGNC:30950 zinc finger protein 639 Q9UID6 Nucleus. Nucleus (GO:0005634) 14522885 nucleus 100 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota ZNF641 HGNC:31834 zinc finger protein 641 Q96N77 Nucleus. Nucleus (GO:0005634) 16343441 nucleus 100 0 nucleus nucleus Eutheria Mammalia Eukaryota ZNF644 HGNC:29222 zinc finger protein 644 Q9H582 Nucleus. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Eumetazoa ZNF645 HGNC:26371 zinc finger protein 645 Q8N7E2 Cytoplasm. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail. cytoplasm 100 0 cytoplasm cytoplasm Catarrhini Catarrhini Eukaryota ZNF646 HGNC:29004 zinc finger protein 646 O15015 Nucleus (Probable). Nucleus (GO:0005634) none,17081983 nucleus 20 0 nucleus nucleus Mammalia Mammalia Eukaryota ZNF648 HGNC:18190 zinc finger protein 648 Q5T619 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) ,17081983 nucleus 36 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF649 HGNC:25741 zinc finger protein 649 Q9BS31 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737) 15950191,15950191 nucleus 100 0 cytoplasm. nucleus multiple Homininae Homininae Eukaryota ZNF652 HGNC:29147 zinc finger protein 652 Q9Y2D9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZNF653 HGNC:25196 zinc finger protein 653 Q96CK0 Nucleus (Probable). Nucleus (GO:0005634) 12920234 nucleus 35 0 nucleus nucleus Mammalia Euteleostomi Eukaryota ZNF654 HGNC:25612 zinc finger protein 654 Q8IZM8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 18 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota ZNF655 HGNC:30899 zinc finger protein 655 Q8N720 Nucleus (Probable). nucleus 29 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF658 HGNC:25226 zinc finger protein 658 Q5TYW1 Nucleus (Probable). nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF660 HGNC:26720 zinc finger protein 660 Q6AZW8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF662 HGNC:31930 zinc finger protein 662 Q6ZS27 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF664 HGNC:25406 zinc finger protein 664 Q8N3J9 Nucleus (Probable). Nucleus (GO:0005634) 8634327 nucleus 54 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF665 HGNC:25885 zinc finger protein 665 Q9H7R5 Nucleus (Probable). nucleus 53 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF667 HGNC:28854 zinc finger protein 667 Q5HYK9 Nucleus (Probable). nucleus 50 0 nucleus nucleus Human Eutheria Eukaryota ZNF668 HGNC:25821 zinc finger protein 668 Q96K58 Nucleus (Probable). Nucleus (GO:0005634) nucleus 29 0 nucleus nucleus Theria Euteleostomi Eukaryota ZNF669 HGNC:25736 zinc finger protein 669 Q96BR6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Human Catarrhini Eukaryota ZNF670 HGNC:28167 zinc finger protein 670 Q9BS34 Nucleus (Probable). nucleus 45 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF671 HGNC:26279 zinc finger protein 671 Q8TAW3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF672 HGNC:26179 zinc finger protein 672 Q499Z4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Human Theria Eukaryota ZNF674 HGNC:17625 zinc finger protein 674 Q2M3X9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus NA NA Eukaryota ZNF675 HGNC:30768 zinc finger protein 675 Q8TD23 Nucleus (Probable). Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11751921,11751921 nucleus 68 0 cytoplasm. nucleus multiple Bilateria Bilateria Cell.Organisms ZNF676 HGNC:20429 zinc finger protein 676 Q8N7Q3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 64 0 nucleus nucleus Bilateria Bilateria NA ZNF677 HGNC:28730 zinc finger protein 677 Q86XU0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF678 HGNC:28652 zinc finger protein 678 Q5SXM1 Nucleus (Probable). nucleus 54 0 nucleus nucleus Homininae Homininae Eukaryota ZNF679 HGNC:28650 zinc finger protein 679 Q8IYX0 Nucleus (Potential). nucleus 56 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF680 HGNC:26897 zinc finger protein 680 Q8NEM1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 64 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF681 HGNC:26457 zinc finger protein 681 Q96N22 Nucleus (Probable). Nucleus (GO:0005634) nucleus 68 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF682 HGNC:28857 zinc finger protein 682 O95780 Nucleus (Probable). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF683 HGNC:28495 zinc finger protein 683 Q8IZ20 Nucleus (Probable). Nucleus (GO:0005634) nucleus 28 0 nucleus nucleus Human Eutheria Eukaryota ZNF684 HGNC:28418 zinc finger protein 684 Q5T5D7 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Human Eutheria Eukaryota ZNF687 HGNC:29277 zinc finger protein 687 Q8N1G0 Nucleus (Probable). Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17000644,17081983,17081983 nucleus 9 0 cytoplasm. nucleus multiple Chordata Chordata Eukaryota ZNF688 HGNC:30489 zinc finger protein 688 P0C7X2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 15 0 nucleus nucleus NA NA Eukaryota ZNF689 HGNC:25173 zinc finger protein 689 Q96CS4 Nucleus (Probable). Nucleus (GO:0005634) 16568080 nucleus 36 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF69 HGNC:13138 zinc finger protein 69 Q9UC07 Nucleus (Probable). nucleus 40 0 nucleus nucleus NA NA Eukaryota ZNF691 HGNC:28028 zinc finger protein 691 Q5VV52 Nucleus (Probable). nucleus 37 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF692 HGNC:26049 zinc finger protein 692 Q9BU19 Nucleus (Probable). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Human Amniota Eukaryota ZNF695 HGNC:30954 zinc finger protein 695 Q8IW36 Nucleus (Potential). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Human Human Eukaryota ZNF696 HGNC:25872 zinc finger protein 696 Q9H7X3 Nucleus (Potential). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF697 HGNC:32034 zinc finger protein 697 Q5TEC3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus NA NA Eukaryota ZNF699 HGNC:24750 zinc finger protein 699 Q32M78 Nucleus (Potential). Nucleus (GO:0005634) 16094367 nucleus 46 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF7 HGNC:13139 zinc finger protein 7 P17097 Nucleus (Probable). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Homininae Eutheria Eukaryota ZNF70 HGNC:13140 zinc finger protein 70 Q9UC06 Nucleus (Potential). Nucleus (GO:0005634) nucleus 55 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF700 HGNC:25292 zinc finger protein 700 Q9H0M5 Nucleus (Potential). nucleus 42 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF701 HGNC:25597 zinc finger protein 701 Q9NV72 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF703 HGNC:25883 zinc finger protein 703 Q9H7S9 Nucleus. Cytoplasm (By similarity). nucleus 51 0 nucleus nucleus Human Euteleostomi Bilateria ZNF704 HGNC:32291 zinc finger protein 704 Q6ZNC4 nucleus 17 0 nucleus nucleus Amniota Deuterostomia Eumetazoa ZNF705A HGNC:32281 zinc finger protein 705A Q6ZN79 Nucleus (Potential). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Human Eutheria Eukaryota ZNF705B HGNC:32284 zinc finger protein 705B P0CI00 Nucleus (Probable). nucleus 31 0 nucleus nucleus Human Eutheria Eukaryota ZNF705D HGNC:33202 zinc finger protein 705D P0CH99 Nucleus (By similarity). nucleus 30 0 nucleus nucleus Human Eutheria Eukaryota ZNF705G HGNC:37134 zinc finger protein 705G A8MUZ8 Nucleus (Potential). nucleus 30 0 nucleus nucleus Homininae Homininae Eukaryota ZNF706 HGNC:24992 zinc finger protein 706 Q9Y5V0 cytoplasm 58 0 cytoplasm cytoplasm Bilateria Bilateria Holozoa ZNF707 HGNC:27815 zinc finger protein 707 Q96C28 Nucleus (Potential). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Euarchontoglires Euarchontoglires NA ZNF708 HGNC:12945 zinc finger protein 708 P17019 Nucleus (Potential). Nucleus (GO:0005634) nucleus 71 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF709 HGNC:20629 zinc finger protein 709 Q8N972 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus NA NA Eukaryota ZNF71 HGNC:13141 zinc finger protein 71 Q9NQZ8 Nucleus (Potential). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Catarrhini Eutheria Cell.Organisms ZNF710 HGNC:25352 zinc finger protein 710 Q8N1W2 Nucleus (Potential). nucleus 57 0 nucleus nucleus Theria Opisthokonta Eukaryota ZNF711 HGNC:13128 zinc finger protein 711 Q9Y462 Nucleus (Probable). Nucleus (GO:0005634) nucleus 56 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF713 HGNC:22043 zinc finger protein 713 Q8N859 Nucleus (Potential). nucleus 49 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF714 HGNC:27124 zinc finger protein 714 Q96N38 Nucleus (Potential). Nucleus (GO:0005634) nucleus 54 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF716 HGNC:32458 zinc finger protein 716 A6NP11 Nucleus (Probable). nucleus 63 0 nucleus nucleus Bilateria Bilateria NA ZNF717 HGNC:29448 zinc finger protein 717 Q9BY31 Nucleus (Potential). nucleus 48 0 nucleus nucleus NA NA Eukaryota ZNF718 HGNC:26889 zinc finger protein 718 Q3SXZ3 Nucleus (Potential). nucleus 51 0 nucleus nucleus NA NA NA ZNF720 HGNC:26987 zinc finger protein 720 Q7Z2F6 Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Human Human Eukaryota ZNF721 HGNC:29425 zinc finger protein 721 Q8TF20 Nucleus (Probable). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Bilateria Bilateria NA ZNF726 HGNC:32462 zinc finger protein 726 A6NNF4 Nucleus (By similarity). nucleus 67 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF728 HGNC:32463 zinc finger protein 728 P0DKX0 nucleus 62 0 nucleus nucleus NA NA NA ZNF729 HGNC:32464 zinc finger protein 729 A6NN14 Nucleus (Potential). nucleus 59 0 nucleus nucleus Bilateria Bilateria NA ZNF730 HGNC:32470 zinc finger protein 730 Q6ZMV8 Nucleus (By similarity). nucleus 62 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF732 HGNC:37138 zinc finger protein 732 B4DXR9 Nucleus (Probable). nucleus 54 0 nucleus nucleus NA NA NA ZNF736 HGNC:32467 zinc finger protein 736 B4DX44 Nucleus (By similarity). nucleus 48 0 nucleus nucleus NA NA Eukaryota ZNF737 HGNC:32468 zinc finger protein 737 O75373 Nucleus (Probable). nucleus 67 0 nucleus nucleus NA NA NA ZNF74 HGNC:13144 zinc finger protein 74 Q16587 Nucleus. Nucleus (GO:0005634) 11313019 nucleus 100 0 nucleus nucleus Human Eutheria Eukaryota ZNF740 HGNC:27465 zinc finger protein 740 Q8NDX6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 32 0 nucleus nucleus Eutheria Opisthokonta Eukaryota ZNF746 HGNC:21948 zinc finger protein 746 Q6NUN9 Cytoplasm. Nucleus (Probable). Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes. Nucleus (GO:0005634) nucleus 22 0 cytoplasm. nucleus multiple Mammalia Mammalia Eukaryota ZNF747 HGNC:28350 zinc finger protein 747 Q9BV97 nucleus 63 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF749 HGNC:32783 zinc finger protein 749 O43361 Nucleus (Probable). nucleus 37 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF750 HGNC:25843 zinc finger protein 750 Q32MQ0 Nucleus. nucleus 100 0 nucleus nucleus Euteleostomi Euteleostomi Craniata ZNF75A HGNC:13146 zinc finger protein 75a Q96N20 Nucleus (Potential). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF75D HGNC:13145 zinc finger protein 75D P51815 Nucleus (Potential). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Eutheria Eutheria NA ZNF76 HGNC:13149 zinc finger protein 76 P36508 Nucleus (Potential). Nucleus (GO:0005634) nucleus 37 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZNF761 HGNC:23179 zinc finger protein 761 Q86XN6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 50 0 nucleus nucleus Bilateria Bilateria NA ZNF763 HGNC:27614 zinc finger protein 763 Q0D2J5 Nucleus (Probable). Nucleus (GO:0005634) nucleus 36 0 nucleus nucleus Homininae Homininae Eukaryota ZNF764 HGNC:28200 zinc finger protein 764 Q96H86 Nucleus (Probable). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF765 HGNC:25092 zinc finger protein 765 Q7L2R6 Nucleus (By similarity). nucleus 45 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF766 HGNC:28063 zinc finger protein 766 Q5HY98 Nucleus (Probable). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF768 HGNC:26273 zinc finger protein 768 Q9H5H4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 42 0 nucleus nucleus Euarchontoglires Euarchontoglires Eukaryota ZNF77 HGNC:13150 zinc finger protein 77 Q15935 Nucleus (Potential). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF770 HGNC:26061 zinc finger protein 770 Q6IQ21 Nucleus (Probable). nucleus 24 0 nucleus nucleus Tetrapoda Tetrapoda Eukaryota ZNF771 HGNC:29653 zinc finger protein 771 Q7L3S4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 40 0 nucleus nucleus Mammalia Mammalia Eukaryota ZNF772 HGNC:33106 zinc finger protein 772 Q68DY9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF773 HGNC:30487 zinc finger protein 773 Q6PK81 Nucleus (Potential). Nucleus (GO:0005634) nucleus 46 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF774 HGNC:33108 zinc finger protein 774 Q6NX45 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Theria Theria Eukaryota ZNF775 HGNC:28501 zinc finger protein 775 Q96BV0 Nucleus (Probable). Nucleus (GO:0005634) none,17081983 nucleus 27 0 nucleus nucleus Euarchontoglires Mammalia Eukaryota ZNF776 HGNC:26765 zinc finger protein 776 Q68DI1 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Human Catarrhini Eukaryota ZNF777 HGNC:22213 zinc finger protein 777 Q9ULD5 Nucleus (Probable). nucleus 34 0 nucleus nucleus Amniota Amniota Eukaryota ZNF778 HGNC:26479 zinc finger protein 778 Q96MU6 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Catarrhini Eukaryota Eukaryota ZNF780A HGNC:27603 zinc finger protein 780A O75290 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF780B HGNC:33109 zinc finger protein 780B Q9Y6R6 Nucleus (Potential). nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF781 HGNC:26745 zinc finger protein 781 Q8N8C0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Homininae Homininae Eukaryota ZNF782 HGNC:33110 zinc finger protein 782 Q6ZMW2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF783 HGNC:27222 zinc finger family member 783 Q6ZMS7 Nucleus (Probable). nucleus 31 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF784 HGNC:33111 zinc finger protein 784 Q8NCA9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 23 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF785 HGNC:26496 zinc finger protein 785 A8K8V0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 33 0 nucleus nucleus Homininae Theria Eukaryota ZNF786 HGNC:21806 zinc finger protein 786 Q8N393 Nucleus (Probable). nucleus 35 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZNF787 HGNC:26998 zinc finger protein 787 Q6DD87 Nucleus (Potential). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Eutheria Eutheria Eukaryota ZNF788 HGNC:33112 zinc finger family member 788 Q6ZQV5 Nucleus (Probable). nucleus 30 0 nucleus nucleus NA NA Opisthokonta ZNF789 HGNC:27801 zinc finger protein 789 Q5FWF6 Nucleus (Probable). nucleus 38 0 nucleus nucleus Homininae Homininae Eukaryota ZNF79 HGNC:13153 zinc finger protein 79 Q15937 Nucleus (Potential). Nucleus (GO:0005634) nucleus 52 0 nucleus nucleus Catarrhini Theria Cell.Organisms ZNF790 HGNC:33114 zinc finger protein 790 Q6PG37 Nucleus (Potential). Nucleus (GO:0005634) nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF791 HGNC:26895 zinc finger protein 791 Q3KP31 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF792 HGNC:24751 zinc finger protein 792 Q3KQV3 Nucleus (Probable). Nucleus (GO:0005634) nucleus 47 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF793 HGNC:33115 zinc finger protein 793 Q6ZN11 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF799 HGNC:28071 zinc finger protein 799 Q96GE5 Nucleus (Probable). nucleus 40 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF8 HGNC:13154 zinc finger protein 8 P17098 Nucleus (Probable). Nucleus (GO:0005634) 12370310 nucleus 44 0 nucleus nucleus Catarrhini Euarchontoglires NA ZNF80 HGNC:13155 zinc finger protein 80 P51504 Nucleus (Probable). Nucleus (GO:0005634) nucleus 43 0 nucleus nucleus Homininae Homininae Eukaryota ZNF800 HGNC:27267 zinc finger protein 800 Q2TB10 Nucleus (Probable). Nucleus (GO:0005634) nucleus 25 0 nucleus nucleus Euteleostomi Euteleostomi Opisthokonta ZNF804A HGNC:21711 zinc finger protein 804A Q7Z570 nucleus 99 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZNF804B HGNC:21958 zinc finger protein 804B A4D1E1 Nucleus (GO:0005634) nucleus 96 0 nucleus nucleus Tetrapoda Euteleostomi Eukaryota ZNF805 HGNC:23272 zinc finger protein 805 Q5CZA5 Nucleus (Probable). nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF806 HGNC:33228 zinc finger protein 806 P0C7X5 Nucleus (Probable). nucleus 39 0 nucleus nucleus Bilateria Bilateria NA ZNF808 HGNC:33230 zinc finger protein 808 Q8N4W9 Nucleus (Probable). nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF81 HGNC:13156 zinc finger protein 81 P51508 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Bilateria Bilateria NA ZNF812 HGNC:33242 zinc finger protein 812 P0C7V5 Nucleus (Potential). nucleus 41 0 nucleus nucleus NA NA Eukaryota ZNF813 HGNC:33257 zinc finger protein 813 Q6ZN06 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF814 HGNC:33258 zinc finger protein 814 B7Z6K7 nucleus 43 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF816 HGNC:26995 zinc finger protein 816 Q0VGE8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF821 HGNC:28043 zinc finger protein 821 O75541 Nucleus (Probable). nucleus 13 0 nucleus nucleus Tetrapoda Euteleostomi Eumetazoa ZNF823 HGNC:30936 zinc finger protein 823 P16415 Nucleus (Probable). nucleus 42 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF827 HGNC:27193 zinc finger protein 827 Q17R98 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 22 0 nucleus nucleus Euteleostomi Euteleostomi Eukaryota ZNF829 HGNC:34032 zinc finger protein 829 Q3KNS6 Nucleus (Probable). nucleus 52 0 nucleus nucleus Catarrhini Theria Eukaryota ZNF83 HGNC:13158 zinc finger protein 83 P51522 Nucleus (Probable). Nucleus (GO:0005634) nucleus 49 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZNF830 HGNC:28291 zinc finger protein 830 Q96NB3 Nucleus (By similarity). Note=Excluded from nucleolus (By similarity). nucleus 81 0 nucleus nucleus Tetrapoda Eukaryota Eukaryota ZNF831 HGNC:16167 zinc finger protein 831 Q5JPB2 nucleus 28 0 nucleus nucleus Amniota Opisthokonta Opisthokonta ZNF835 HGNC:34332 zinc finger protein 835 Q9Y2P0 Nucleus (Probable). Nucleus (GO:0005634) nucleus 48 0 nucleus nucleus Catarrhini Catarrhini Cell.Organisms ZNF836 HGNC:34333 zinc finger protein 836 Q6ZNA1 Nucleus (Probable). nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF837 HGNC:25164 zinc finger protein 837 Q96EG3 Nucleus (Potential). nucleus 40 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZNF839 HGNC:20345 zinc finger protein 839 A8K0R7 nucleus 86 0 nucleus nucleus Amniota Euteleostomi Bilateria ZNF84 HGNC:13159 zinc finger protein 84 P51523 Nucleus (Probable). Nucleus (GO:0005634) nucleus 53 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF841 HGNC:27611 zinc finger protein 841 Q6ZN19 Nucleus (By similarity). nucleus 49 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF843 HGNC:28710 zinc finger protein 843 Q8N446 nucleus 39 0 nucleus nucleus Human Human Opisthokonta ZNF844 HGNC:25932 zinc finger protein 844 Q08AG5 Nucleus (By similarity). nucleus 39 0 nucleus nucleus NA NA Eukaryota ZNF845 HGNC:25112 zinc finger protein 845 Q96IR2 Nucleus (By similarity). nucleus 50 0 nucleus nucleus NA NA Eukaryota ZNF846 HGNC:27260 zinc finger protein 846 Q147U1 Nucleus (By similarity). nucleus 50 0 nucleus nucleus Homininae Homininae Eukaryota ZNF85 HGNC:13160 zinc finger protein 85 Q03923 Nucleus. Nucleus (GO:0005634) 9839802 nucleus 100 0 nucleus nucleus Bilateria Bilateria NA ZNF850 HGNC:27994 zinc finger protein 850 A8MQ14 Nucleus (By similarity). nucleus 50 0 nucleus nucleus NA NA NA ZNF852 HGNC:27713 zinc finger protein 852 Q6ZMS4 nucleus 51 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF853 HGNC:21767 zinc finger protein 853 P0CG23 nucleus 41 1 nucleus nucleus NA NA Eukaryota ZNF860 HGNC:34513 zinc finger protein 860 A6NHJ4 Nucleus (By similarity). nucleus 46 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF862 HGNC:34519 zinc finger protein 862 O60290 Nucleus (Potential). nucleus 40 1 nucleus nucleus Mammalia Eukaryota Eukaryota ZNF865 HGNC:38705 zinc finger protein 865 P0CJ78 Nucleus (By similarity). nucleus 29 0 nucleus nucleus NA NA Eukaryota ZNF878 HGNC:37246 zinc finger protein 878 C9JN71 Nucleus (Potential). nucleus 46 0 nucleus nucleus NA NA Eukaryota ZNF879 HGNC:37273 zinc finger protein 879 B4DU55 Nucleus (Probable). nucleus 50 0 nucleus nucleus NA NA Eukaryota ZNF880 HGNC:37249 zinc finger protein 880 Q6PDB4 nucleus 59 0 nucleus nucleus NA NA Eukaryota ZNF883 HGNC:27271 zinc finger protein 883 P0CG24 Nucleus (By similarity). nucleus 47 0 nucleus nucleus NA NA NA ZNF888 HGNC:38695 zinc finger protein 888 P0CJ79 Nucleus (By similarity). nucleus 44 0 nucleus nucleus NA NA Tetrapoda ZNF891 HGNC:38709 zinc finger protein 891 A8MT65 Nucleus (By similarity). nucleus 46 0 nucleus nucleus Human Eutheria Eukaryota ZNF90 HGNC:13165 zinc finger protein 90 Q03938 Nucleus (Probable). Nucleus (GO:0005634) nucleus 64 0 nucleus nucleus NA NA NA ZNF91 HGNC:13166 zinc finger protein 91 Q05481 Nucleus (Probable). Nucleus (GO:0005634) nucleus 63 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF92 HGNC:13168 zinc finger protein 92 Q03936 Nucleus (Probable). Nucleus (GO:0005634) nucleus 67 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNF93 HGNC:13169 zinc finger protein 93 P35789 Nucleus (Probable). Nucleus (GO:0005634) nucleus 68 0 nucleus nucleus Human Human Eukaryota ZNF98 HGNC:13174 zinc finger protein 98 A6NK75 Nucleus (Probable). nucleus 65 0 nucleus nucleus Bilateria Bilateria Cell.Organisms ZNF99 HGNC:13175 zinc finger protein 99 A8MXY4 Nucleus (Probable). Nucleus (GO:0005634) nucleus 63 0 nucleus nucleus Bilateria Bilateria Eukaryota ZNFX1 HGNC:29271 zinc finger, NFX1-type containing 1 Q9P2E3 Nucleus (GO:0005634) cytoplasm 34 0 cytoplasm cytoplasm Opisthokonta Eukaryota Cell.Organisms ZNHIT1 HGNC:21688 zinc finger, HIT-type containing 1 O43257 nucleus 36 0 nucleus nucleus Theria Eukaryota Eukaryota ZNHIT2 HGNC:1177 zinc finger, HIT-type containing 2 Q9UHR6 Nucleus (GO:0005634) 10873569 nucleus 79 0 nucleus nucleus Theria Eukaryota Eukaryota ZNHIT3 HGNC:12309 zinc finger, HIT-type containing 3 Q15649 Nucleus (GO:0005634) none,17081983 nucleus 64 0 nucleus nucleus Euteleostomi Eukaryota NA ZNHIT6 HGNC:26089 zinc finger, HIT-type containing 6 Q9NWK9 nucleus 45 0 nucleus nucleus Eukaryota Eukaryota Eukaryota ZNRD1 HGNC:13182 zinc ribbon domain containing 1 Q9P1U0 Nucleus, nucleolus (By similarity). Nucleus (GO:0005634) nucleus 25 0 nucleus nucleus Theria Cell.Organisms NA ZNRF1 HGNC:18452 zinc and ring finger 1, E3 ubiquitin protein ligase Q8ND25 Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Associated with synaptic vesicle membranes in neurons. Cytoplasmic vesicle (GO:0016023) 14561866 endoplasmic reticulum membrane 39 0 endosome. lysosome multiple Euteleostomi Euteleostomi Eukaryota ZNRF2 HGNC:22316 zinc and ring finger 2 Q8NHG8 Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Note=Present in presynaptic plasma membranes in neurons. Endosome (GO:0005768); Lysosome (GO:0005764) 14561866,14561866 nucleus 26 0 endosome. lysosome multiple Bilateria Eukaryota Eukaryota ZNRF3 HGNC:18126 zinc and ring finger 3 Q9ULT6 Cell membrane; Single-pass type I membrane protein. plasma membrane 100 1 plasma membrane plasma membrane Euteleostomi Euteleostomi Cell.Organisms ZNRF4 HGNC:17726 zinc and ring finger 4 Q8WWF5 Membrane; Single-pass type I membrane protein (Potential). Cytoplasm (GO:0005737) 10191088 endoplasmic reticulum membrane 30 1 cytoplasm cytoplasm Mammalia Mammalia Eukaryota ZP1 HGNC:13187 zona pellucida glycoprotein 1 (sperm receptor) P60852 Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular matrix. Cell membrane; Single-pass type I membrane protein. Cell surface (GO:0009986) nucleus 9 1 plasma membrane. secreted multiple Amniota Amniota Eumetazoa ZP2 HGNC:13188 zona pellucida glycoprotein 2 (sperm receptor) Q05996 Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576) 8385033 nucleus 13 1 plasma membrane. secreted multiple Tetrapoda Tetrapoda Eumetazoa ZP3 HGNC:13189 zona pellucida glycoprotein 3 (sperm receptor) P21754 Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix. Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Plasma membrane (GO:0005886) 11804956,11940668 nucleus 13 1 plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa ZP4 HGNC:15770 zona pellucida glycoprotein 4 Q12836 Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix. Cell membrane; Single-pass type I membrane protein. Extracellular (GO:0005576); Cytoplasm (GO:0005737) 11804956,11291774 plasma membrane 17 1 cytoplasm. plasma membrane. secreted multiple Euteleostomi Euteleostomi Eumetazoa ZPBP HGNC:15662 zona pellucida binding protein Q9BS86 Secreted (Potential). Integral to membrane (GO:0016021); Extracellular (GO:0005576) 12883658, secreted 68 0 secreted secreted Amniota Amniota Craniata ZPBP2 HGNC:20678 zona pellucida binding protein 2 Q6X784 Secreted (Potential). Extracellular (GO:0005576) 12883658 secreted 79 0 secreted secreted Amniota Amniota Craniata ZPLD1 HGNC:27022 zona pellucida-like domain containing 1 Q8TCW7 Membrane; Single-pass type I membrane protein (Potential). secreted 9 1 secreted secreted Euteleostomi Euteleostomi Eumetazoa ZPR1 HGNC:13051 ZPR1 zinc finger O75312 Cytoplasm. Nucleus, nucleolus. Note=Translocates to the nucleolus after treatment with mitogens. Cytoplasm (GO:0005737); Nucleolus (GO:0005730) 9763455,9763455 nucleus 61 0 cytoplasm. nucleus multiple Cell.Organisms Cell.Organisms Cell.Organisms ZRANB1 HGNC:18224 zinc finger, RAN-binding domain containing 1 Q9UGI0 Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm. Cytoplasm (GO:0005737); Nucleus (GO:0005634) 11463333,11463333 cytoplasm 18 0 cytoplasm. nucleus multiple Deuterostomia Bilateria Eukaryota ZRANB2 HGNC:13058 zinc finger, RAN-binding domain containing 2 O95218 Nucleus. Nucleus (GO:0005634); Cytoplasm (GO:0005737);Nucleus (GO:0005634); Cytoplasm (GO:0005737) 17081983,17081983/11448987,16982639,11448987 nucleus 100 0 cytoplasm. nucleus multiple Bilateria Bilateria Eukaryota ZRANB3 HGNC:25249 zinc finger, RAN-binding domain containing 3 Q5FWF4 Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA. Nucleus (GO:0005634) nucleus 100 0 nucleus nucleus Eukaryota Cell.Organisms Cell.Organisms ZRSR1 HGNC:12456 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 Q15695 Nucleus (Potential). nucleus 90 0 nucleus nucleus Amniota Eukaryota Eukaryota ZRSR2 HGNC:23019 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 Q15696 Nucleus. Nucleus (GO:0005634) 9237760 nucleus 100 0 nucleus nucleus Amniota Eukaryota Eukaryota ZSCAN1 HGNC:23712 zinc finger and SCAN domain containing 1 Q8NBB4 Nucleus (Potential). nucleus 18 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZSCAN10 HGNC:12997 zinc finger and SCAN domain containing 10 Q96SZ4 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 65 0 nucleus nucleus Mammalia Mammalia Eukaryota ZSCAN12 HGNC:13172 zinc finger and SCAN domain containing 12 O43309 Nucleus (Potential). Nucleus (GO:0005634) ,17000644 nucleus 42 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZSCAN16 HGNC:20813 zinc finger and SCAN domain containing 16 Q9H4T2 Nucleus (Probable). Nucleus (GO:0005634) nucleus 41 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZSCAN18 HGNC:21037 zinc finger and SCAN domain containing 18 Q8TBC5 Nucleus (Potential). Nucleus (GO:0005634) nucleus 16 0 nucleus nucleus Euarchontoglires Eutheria Eukaryota ZSCAN2 HGNC:20994 zinc finger and SCAN domain containing 2 Q7Z7L9 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 87 0 nucleus nucleus Amniota Amniota Eukaryota ZSCAN20 HGNC:13093 zinc finger and SCAN domain containing 20 P17040 Nucleus (Potential). Nucleus (GO:0005634) nucleus 54 0 nucleus nucleus Mammalia Mammalia Eukaryota ZSCAN21 HGNC:13104 zinc finger and SCAN domain containing 21 Q9Y5A6 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 76 0 nucleus nucleus Homininae Eutheria Eukaryota ZSCAN22 HGNC:4929 zinc finger and SCAN domain containing 22 P10073 Nucleus (Potential). Nucleus (GO:0005634) nucleus 45 0 nucleus nucleus Euarchontoglires Theria Eukaryota ZSCAN23 HGNC:21193 zinc finger and SCAN domain containing 23 Q3MJ62 Nucleus (Potential). nucleus 43 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZSCAN25 HGNC:21961 zinc finger and SCAN domain containing 25 Q6NSZ9 Nucleus (By similarity). nucleus 34 0 nucleus nucleus Eutheria Eutheria Eukaryota ZSCAN26 HGNC:12978 zinc finger and SCAN domain containing 26 Q16670 Nucleus. Nucleus (GO:0005634) 1569959 nucleus 100 0 nucleus nucleus NA NA NA ZSCAN29 HGNC:26673 zinc finger and SCAN domain containing 29 Q8IWY8 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus Mammalia Mammalia Eukaryota ZSCAN30 HGNC:33517 zinc finger and SCAN domain containing 30 Q86W11 Nucleus (Probable). nucleus 45 0 nucleus nucleus Human Eutheria Eukaryota ZSCAN31 HGNC:14097 zinc finger and SCAN domain containing 31 Q96LW9 Nucleus (Probable). Nucleus (GO:0005634) nucleus 44 0 nucleus nucleus NA NA Eukaryota ZSCAN32 HGNC:20812 zinc finger and SCAN domain containing 32 Q9NX65 Nucleus (Potential). Nucleus (GO:0005634) nucleus 39 0 nucleus nucleus Catarrhini Catarrhini Eukaryota ZSCAN4 HGNC:23709 zinc finger and SCAN domain containing 4 Q8NAM6 Nucleus (By similarity). Chromosome, telomere (By similarity). Nucleus (GO:0005634) nucleus 31 0 nucleus nucleus Eutheria Eutheria Eukaryota ZSCAN5A HGNC:23710 zinc finger and SCAN domain containing 5A Q9BUG6 Nucleus (Potential). Nucleus (GO:0005634) nucleus 31 0 nucleus nucleus Eutheria Eutheria Eukaryota ZSCAN5B HGNC:34246 zinc finger and SCAN domain containing 5B A6NJL1 Nucleus (By similarity). nucleus 34 0 nucleus nucleus Eutheria Eutheria Eukaryota ZSCAN5C HGNC:34294 zinc finger and SCAN domain containing 5C A6NGD5 Nucleus (By similarity). nucleus 32 0 nucleus nucleus Eutheria Eutheria Eukaryota ZSCAN9 HGNC:12984 zinc finger and SCAN domain containing 9 O15535 Nucleus (Potential). Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Catarrhini Eutheria Eukaryota ZSWIM1 HGNC:16155 zinc finger, SWIM-type containing 1 Q9BR11 nucleus 27 1 nucleus nucleus Human Tetrapoda Metazoa ZSWIM2 HGNC:30990 zinc finger, SWIM-type containing 2 Q8NEG5 Nucleus (GO:0005634) plasma membrane 39 0 n/a n/a Theria Deuterostomia Eukaryota ZSWIM3 HGNC:16157 zinc finger, SWIM-type containing 3 Q96MP5 Nucleus (GO:0005634) nucleus 35 0 nucleus nucleus Theria Amniota Metazoa ZSWIM4 HGNC:25704 zinc finger, SWIM-type containing 4 Q9H7M6 nucleus 38 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms ZSWIM5 HGNC:29299 zinc finger, SWIM-type containing 5 Q9P217 nucleus 27 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms ZSWIM6 HGNC:29316 zinc finger, SWIM-type containing 6 Q9HCJ5 nucleus 20 0 nucleus nucleus Deuterostomia Bilateria Cell.Organisms ZSWIM7 HGNC:26993 zinc finger, SWIM-type containing 7 Q19AV6 Nucleus (Probable). Nucleus (GO:0005634) 16710300 cytoplasm 52 0 nucleus nucleus Deuterostomia Eukaryota Eukaryota ZSWIM8 HGNC:23528 zinc finger, SWIM-type containing 8 A7E2V4 cytoplasm 22 0 cytoplasm cytoplasm Bilateria Bilateria Cell.Organisms ZUFSP HGNC:21224 zinc finger with UFM1-specific peptidase domain Q96AP4 Nucleus (GO:0005634) nucleus 89 0 nucleus nucleus Euteleostomi Eukaryota Eukaryota ZW10 HGNC:13194 zw10 kinetochore protein O43264 Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone. Kinetochore (GO:0000776); Cytoplasm (GO:0005737); Chromosome (GO:0005694) 15824131,16732327,15561729,11146660,11129339 nucleus 80 0 cytoplasm. nucleus multiple Bilateria Eukaryota Eukaryota ZWILCH HGNC:25468 zwilch kinetochore protein Q9H900 Chromosome, centromere, kinetochore. Cytoplasm (GO:0005737); Kinetochore (GO:0000776) 12686595,12686595,15824131,15561729 nucleus 100 0 cytoplasm. nucleus multiple Chordata Chordata Opisthokonta ZWINT HGNC:13195 ZW10 interacting kinetochore protein O95229 Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Nucleus (GO:0005634); Cytoplasm (GO:0005737); Kinetochore (GO:0000776) 10806105,15485811,10806105,10806105,15824131,16732327,15561729 nucleus 100 0 cytoplasm. nucleus multiple Eutheria Eutheria Amniota ZXDA HGNC:13198 zinc finger, X-linked, duplicated A P98168 Nucleus (Probable). Nucleus (GO:0005634) nucleus 34 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZXDB HGNC:13199 zinc finger, X-linked, duplicated B P98169 Nucleus (Probable). Nucleus (GO:0005634) nucleus 22 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZXDC HGNC:28160 ZXD family zinc finger C Q2QGD7 Nucleus (Probable). nucleus 26 0 nucleus nucleus Euteleostomi Deuterostomia Eukaryota ZYG11A HGNC:32058 zyg-11 family member A, cell cycle regulator Q6WRX3 nucleus 67 0 nucleus nucleus Euteleostomi Bilateria Holozoa ZYG11B HGNC:25820 zyg-11 family member B, cell cycle regulator Q9C0D3 nucleus 78 0 nucleus nucleus Euteleostomi Bilateria Eumetazoa ZYX HGNC:13200 zyxin Q15942 Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1. Plasma membrane (GO:0005886); Cytoplasm (GO:0005737); Nucleus (GO:0005634) 8940160,16137684,11689660,17081983,8940160,11689660,16137684,17081983 secreted 22 0 cytoplasm. nucleus multiple Theria Amniota Eukaryota ZZEF1 HGNC:29027 zinc finger, ZZ-type with EF-hand domain 1 O43149 golgi apparatus 29 2 golgi apparatus golgi apparatus Amniota Deuterostomia Eukaryota ZZZ3 HGNC:24523 zinc finger, ZZ-type containing 3 Q8IYH5 Nucleus (By similarity). Nucleus (GO:0005634) nucleus 30 0 nucleus nucleus Deuterostomia Bilateria Eukaryota