Coexpression cluster:C3303

Full id: C3303_Smooth_Adipocyte_smooth_Mallassezderived_Fibroblast_Endothelial_Aortic

Phase1 CAGE Peaks

Hg19::chr12:56552128..56552162,+	p1@MYL6
Hg19::chr12:56554057..56554082,-	p@chr12:56554057..56554082 -
Hg19::chr17:69617073..69617130,+	p1@ENST00000412707 p1@ENST00000545441

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030898	actin-dependent ATPase activity	0.00269830056124651
GO:0030049	muscle filament sliding	0.00269830056124651
GO:0033275	actin-myosin filament sliding	0.00269830056124651
GO:0016461	unconventional myosin complex	0.00283321558930884
GO:0030048	actin filament-based movement	0.00518073707759331
GO:0008307	structural constituent of muscle	0.0113328623572354
GO:0007519	skeletal muscle development	0.01549595465173
GO:0014706	striated muscle development	0.017808783704227
GO:0016459	myosin complex	0.0192478773368918
GO:0003012	muscle system process	0.02320538482672
GO:0006936	muscle contraction	0.02320538482672
GO:0007517	muscle development	0.02320538482672
GO:0030705	cytoskeleton-dependent intracellular transport	0.0244092420001992
GO:0030029	actin filament-based process	0.0300667776824612
GO:0015629	actin cytoskeleton	0.0319478786451587

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.