Coexpression cluster:C4699

Full id: C4699_Mesenchymal_Urothelial_vagina_Renal_MCF7_salivary_skeletal

Phase1 CAGE Peaks

Hg19::chr7:75931982..75932005,+	p1@HSPB1
Hg19::chr7:75932326..75932393,-	p@chr7:75932326..75932393 -
Hg19::chrX:49090623..49090648,-	p2@HSPB1P2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006446	regulation of translational initiation	0.0362062875309078
GO:0006986	response to unfolded protein	0.0362062875309078
GO:0051789	response to protein stimulus	0.0362062875309078
GO:0006413	translational initiation	0.0362062875309078
GO:0022618	protein-RNA complex assembly	0.0362062875309078
GO:0009986	cell surface	0.0362062875309078
GO:0006916	anti-apoptosis	0.0362062875309078
GO:0006417	regulation of translation	0.0362062875309078
GO:0031326	regulation of cellular biosynthetic process	0.0362062875309078
GO:0009889	regulation of biosynthetic process	0.0362062875309078
GO:0043066	negative regulation of apoptosis	0.0362062875309078
GO:0043069	negative regulation of programmed cell death	0.0362062875309078
GO:0022613	ribonucleoprotein complex biogenesis and assembly	0.0362062875309078
GO:0009607	response to biotic stimulus	0.0394968125010513
GO:0051674	localization of cell	0.0458005857765218
GO:0006928	cell motility	0.0458005857765218
GO:0051246	regulation of protein metabolic process	0.0474958616438451

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.