UBERON:0002513: Difference between revisions
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|name=endochondral bone | |name=endochondral bone | ||
|namespace= | |namespace= | ||
|def="Replacement bone that forms within cartilage[TAO]. Endochondral ossification is the formation of bone by the replacement of cartilage tissue with mineralized bone[GO]. cartilage is present during endochondral ossification. It is also an essential process during the rudimentary formation of long bones, the growth of the length of long bones, and the natural healing of bone fractures[WP]." [GO:0001958, Wikipedia: | |def="Replacement bone that forms within cartilage[TAO]. Endochondral ossification is the formation of bone by the replacement of cartilage tissue with mineralized bone[GO]. cartilage is present during endochondral ossification. It is also an essential process during the rudimentary formation of long bones, the growth of the length of long bones, and the natural healing of bone fractures[WP]." [GO:0001958, Wikipedia:Endochondral_ossification] | ||
|xref=AAO:0010776;;AEO:0000083;;BTO:0002157;;EHDAA2:0003083;; | |xref=AAO:0010776;;AEO:0000083;;BTO:0002157;;EHDAA2:0003083;;http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg;;TAO:0001591;;VSAO:0000145;;XAO:0004018;;ZFA:0001591 | ||
|is_a=UBERON:0001474 | |is_a=UBERON:0001474;;UBERON:0010363 | ||
|synonym="cartilaginous bone" RELATED [BTO:0002157] | |synonym="cartilaginous bone" RELATED [BTO:0002157] | ||
|comment=note that some structures, e.g. in ZFA are both intramembrane and endochondral | |comment=note that some structures, e.g. in ZFA are both intramembrane and endochondral. Editor notes: placement in this class to be inferred | ||
|alt_id=UBERON:MA_0002836-ZFA_0001591 | |alt_id=UBERON:MA_0002836-ZFA_0001591 | ||
|disjoint_from= | |disjoint_from= | ||
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|obo_creation_date= | |obo_creation_date= | ||
|subset=uberon_slim;;vertebrate_core | |subset=uberon_slim;;vertebrate_core | ||
|derives_from= | |derives_from= | ||
|develops_from= | |develops_from= | ||
| Line 20: | Line 19: | ||
|located_in= | |located_in= | ||
|part_of= | |part_of= | ||
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl | |property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl;;UBPROP:0000001 "Replacement bone that forms within cartilage.[AAO]" xsd:string;;UBPROP:0000001 "Replacement bone that forms within cartilage.[TAO]" xsd:string;;UBPROP:0000001 "Replacement bone that forms within cartilage.[VSAO]" xsd:string | ||
|is_obsolete= | |is_obsolete= | ||
|preceded_by= | |preceded_by= | ||
}} | }} | ||
Revision as of 17:02, 26 June 2012
| Name: | endochondral bone | ||
|---|---|---|---|
| Definition: | "Replacement bone that forms within cartilage[TAO]. Endochondral ossification is the formation of bone by the replacement of cartilage tissue with mineralized bone[GO]. cartilage is present during endochondral ossification. It is also an essential process during the rudimentary formation of long bones, the growth of the length of long bones, and the natural healing of bone fractures[WP]." [GO:0001958, Wikipedia:Endochondral_ossification] | ||
| Xrefs: |
| ||
| Synonyms: | "cartilaginous bone" RELATED [BTO:0002157] | ||
| Comments: | note that some structures, e.g. in ZFA are both intramembrane and endochondral. Editor notes: placement in this class to be inferred | ||
| Alt_id: | UBERON:MA_0002836-ZFA_0001591 | ||
| Subset: |
uberon_slim vertebrate_core |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | UBERON:0001474(bone element),UBERON:0010363(endochondral element) |
|---|
Children
| is a: | UBERON:0002412 (vertebra),UBERON:0002428 (limb bone) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Human (Homo sapiens)
- 11219-116B4 (Mesenchymal Stem Cells - Vertebral, donor1)
- 1350-25C3 (bone (os femoris), neonate N20)
- 1525-43A6 (bone (os femoris), neonate N16)
- 1985-43F5 (bone (os femoris), neonate N02)
- 56-12G2 (bone (os femoris), adult)
Mouse (Mus musculus)
- 11219-116B4 (Mesenchymal Stem Cells - Vertebral, donor1)
- 1350-25C3 (bone (os femoris), neonate N20)
- 1525-43A6 (bone (os femoris), neonate N16)
- 1985-43F5 (bone (os femoris), neonate N02)
- 56-12G2 (bone (os femoris), adult)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002513 (endochondral bone), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 3.4e-49 | FFCP PHASE1:Mm9::chr11:77624716..77624729,+#_f93f91d7345d16a0da86757b0b6334cb | p26@Myo18a |
| 3.4e-49 | FFCP PHASE2:Mm9::chr11:77624716..77624729,+#_f93f91d7345d16a0da86757b0b6334cb | p26@Myo18a |
| 4.96e-49 | FFCP PHASE2:Mm9::chr2:32482372..32482381,+#_b4c6c3df0f56f623580e1e4ed57cce47 | p@chr2:32482372..32482381, + |
| 4.96e-49 | FFCP PHASE2:Mm9::chr9:21934585..21934591,-#_b4c6c3df0f56f623580e1e4ed57cce47 | p@chr9:21934585..21934591, - |
| 4.96e-49 | FFCP PHASE1:Mm9::chr8:75097542..75097549,+#_b4c6c3df0f56f623580e1e4ed57cce47 | p@chr8:75097542..75097549, + |
| 4.96e-49 | FFCP PHASE1:Mm9::chr2:32482372..32482381,+#_b4c6c3df0f56f623580e1e4ed57cce47 | p@chr2:32482372..32482381, + |
| 4.96e-49 | FFCP PHASE2:Mm9::chr8:75097542..75097549,+#_b4c6c3df0f56f623580e1e4ed57cce47 | p@chr8:75097542..75097549, + |
| 4.96e-49 | FFCP PHASE1:Mm9::chr9:21934585..21934591,-#_b4c6c3df0f56f623580e1e4ed57cce47 | p@chr9:21934585..21934591, - |
| 3.15e-44 | FFCP PHASE1:Mm9::chr6:51525810..51525817,+#_701d66c1356aba504662ab9605468be3 | p@chr6:51525810..51525817, + |
| 3.15e-44 | FFCP PHASE2:Mm9::chr6:51525810..51525817,+#_701d66c1356aba504662ab9605468be3 | p@chr6:51525810..51525817, + |
| 9.78e-40 | FFCP PHASE1:Mm9::chr19:4876870..4876880,-#_df79a1622c5191ee8dd2a0a3c7e1b47b | p@chr19:4876870..4876880, - |
| 9.78e-40 | FFCP PHASE2:Mm9::chr19:4876870..4876880,-#_df79a1622c5191ee8dd2a0a3c7e1b47b | p@chr19:4876870..4876880, - |
| 1.15e-39 | FFCP PHASE2:Mm9::chr11:67063327..67063335,+#_b368309d9908e2c4a906b175a9877bb1 | p@chr11:67063327..67063335, + |
| 1.15e-39 | FFCP PHASE1:Mm9::chr16:24096441..24096449,+#_b368309d9908e2c4a906b175a9877bb1 | p@chr16:24096441..24096449, + |
| 1.15e-39 | FFCP PHASE1:Mm9::chr6:4490674..4490679,+#_b368309d9908e2c4a906b175a9877bb1 | p@chr6:4490674..4490679, + |
| 1.15e-39 | FFCP PHASE2:Mm9::chr6:4490674..4490679,+#_b368309d9908e2c4a906b175a9877bb1 | p@chr6:4490674..4490679, + |
| 1.15e-39 | FFCP PHASE1:Mm9::chr11:67063327..67063335,+#_b368309d9908e2c4a906b175a9877bb1 | p@chr11:67063327..67063335, + |
| 1.15e-39 | FFCP PHASE2:Mm9::chr16:24096441..24096449,+#_b368309d9908e2c4a906b175a9877bb1 | p@chr16:24096441..24096449, + |
| 1.15e-39 | FFCP PHASE2:Mm9::chr1:174140324..174140335,-#_b368309d9908e2c4a906b175a9877bb1 | p@chr1:174140324..174140335, - |
| 1.15e-39 | FFCP PHASE1:Mm9::chr1:174140324..174140335,-#_b368309d9908e2c4a906b175a9877bb1 | p@chr1:174140324..174140335, - |
| 1.55e-39 | FFCP PHASE2:Mm9::chr1:174143249..174143260,-#_75d54654d4c168920b4ac06cf0eb45ec | p@chr1:174143249..174143260, - |
| 1.55e-39 | FFCP PHASE1:Mm9::chr1:174143249..174143260,-#_75d54654d4c168920b4ac06cf0eb45ec | p@chr1:174143249..174143260, - |
| 3.03e-39 | FFCP PHASE2:Mm9::chr6:51525869..51525891,+#_afa034c70fa4d5a9766aadac056d787e | p@chr6:51525869..51525891, + |
| 3.03e-39 | FFCP PHASE1:Mm9::chr6:51525869..51525891,+#_afa034c70fa4d5a9766aadac056d787e | p@chr6:51525869..51525891, + |
| 9.31e-39 | FFCP PHASE2:Mm9::chr11:102130083..102130092,+#_4d99952ae5a61ac15ad07c36110adcab | p3@Asb16 |
| 9.31e-39 | FFCP PHASE1:Mm9::chr11:102130083..102130092,+#_4d99952ae5a61ac15ad07c36110adcab | p3@Asb16 |
| 2.41e-35 | FFCP PHASE1:Mm9::chr7:133604286..133604297,-#_ef13dfde4b634d40f298aa24cd6374fe | p@chr7:133604286..133604297, - |
| 2.41e-35 | FFCP PHASE2:Mm9::chr7:133604286..133604297,-#_ef13dfde4b634d40f298aa24cd6374fe | p@chr7:133604286..133604297, - |
| 2.95e-35 | FFCP PHASE2:Mm9::chr4:138365748..138365759,-#_ce18ac7acee80a005a19942aa97cb1e1 | p5@Pla2g5 |
| 2.95e-35 | FFCP PHASE1:Mm9::chr4:138365748..138365759,-#_ce18ac7acee80a005a19942aa97cb1e1 | p5@Pla2g5 |
| 9.53e-34 | FFCP PHASE2:Mm9::chr8:74049600..74049612,-#_c149f6f267e431648b38cb28270d8415 | p2@uc009mdq.1 |
| 9.53e-34 | FFCP PHASE1:Mm9::chr8:74049600..74049612,-#_c149f6f267e431648b38cb28270d8415 | p2@uc009mdq.1 |
| 1.23e-33 | FFCP PHASE2:Mm9::chr2:164773241..164773248,+#_586fc35e35b09be25ebd5b43328fc367 | p3@Mmp9 |
| 1.23e-33 | FFCP PHASE1:Mm9::chr2:164773241..164773248,+#_586fc35e35b09be25ebd5b43328fc367 | p3@Mmp9 |
| 1.58e-33 | FFCP PHASE2:Mm9::chr7:3567707..3567718,-#_279c72482721b2a5e8d27a2bcab3ad97 | p2@Oscar |
| 1.58e-33 | FFCP PHASE2:Mm9::chr1:166815111..166815121,-#_279c72482721b2a5e8d27a2bcab3ad97 | p@chr1:166815111..166815121, - |
| 1.58e-33 | FFCP PHASE1:Mm9::chr1:166815111..166815121,-#_279c72482721b2a5e8d27a2bcab3ad97 | p@chr1:166815111..166815121, - |
| 1.58e-33 | FFCP PHASE1:Mm9::chr7:3567707..3567718,-#_279c72482721b2a5e8d27a2bcab3ad97 | p2@Oscar |
| 2.04e-33 | FFCP PHASE1:Mm9::chr9:70799951..70799962,-#_13945683a5a2460c181757bb0878a2e2 | p4@Lipc |
| 2.04e-33 | FFCP PHASE2:Mm9::chr9:70799951..70799962,-#_13945683a5a2460c181757bb0878a2e2 | p4@Lipc |
| 2.04e-33 | FFCP PHASE1:Mm9::chr11:75409652..75409664,+#_13945683a5a2460c181757bb0878a2e2 | p@chr11:75409652..75409664, + |
| 2.04e-33 | FFCP PHASE2:Mm9::chr11:75409652..75409664,+#_13945683a5a2460c181757bb0878a2e2 | p@chr11:75409652..75409664, + |
| 3.38e-33 | FFCP PHASE1:Mm9::chr15:102196702..102196713,-#_b0277c028c0229c4a882f2d3c2c67364 | p6@Sp7 |
| 3.38e-33 | FFCP PHASE2:Mm9::chr15:102196702..102196713,-#_b0277c028c0229c4a882f2d3c2c67364 | p6@Sp7 |
| 7.17e-33 | FFCP PHASE1:Mm9::chr8:126415826..126415839,+#_8c6c33231a405a3f8dc210958d5588f6 | p@chr8:126415826..126415839, + |
| 7.17e-33 | FFCP PHASE2:Mm9::chr8:126415826..126415839,+#_8c6c33231a405a3f8dc210958d5588f6 | p@chr8:126415826..126415839, + |
| 7.17e-33 | FFCP PHASE1:Mm9::chr18:76271498..76271508,+#_8c6c33231a405a3f8dc210958d5588f6 | p@chr18:76271498..76271508, + |
| 7.17e-33 | FFCP PHASE2:Mm9::chr18:76271498..76271508,+#_8c6c33231a405a3f8dc210958d5588f6 | p@chr18:76271498..76271508, + |
| 2.67e-30 | FFCP PHASE2:Mm9::chr2:32482387..32482399,+#_1e082a1fd9465fa1ee769a1272f12074 | p@chr2:32482387..32482399, + |
| 2.67e-30 | FFCP PHASE1:Mm9::chr2:32482387..32482399,+#_1e082a1fd9465fa1ee769a1272f12074 | p@chr2:32482387..32482399, + |
| 1.1e-29 | FFCP PHASE2:Mm9::chr15:58649683..58649688,-#_b31dd029bfc75362df2624528d5d0aee | p@chr15:58649683..58649688, - |
| 1.1e-29 | FFCP PHASE1:Mm9::chr15:58649683..58649688,-#_b31dd029bfc75362df2624528d5d0aee | p@chr15:58649683..58649688, - |
| 1.1e-29 | FFCP PHASE2:Mm9::chr12:70396969..70396979,+#_b31dd029bfc75362df2624528d5d0aee | p@chr12:70396969..70396979, + |
| 1.1e-29 | FFCP PHASE1:Mm9::chr12:70396969..70396979,+#_b31dd029bfc75362df2624528d5d0aee | p@chr12:70396969..70396979, + |
| 1.46e-29 | FFCP PHASE1:Mm9::chr7:133590998..133591009,-#_f8d4c278fc3eb6b784222d4ef7079d5b | p@chr7:133590998..133591009, - |
| 1.46e-29 | FFCP PHASE2:Mm9::chr7:133590998..133591009,-#_f8d4c278fc3eb6b784222d4ef7079d5b | p@chr7:133590998..133591009, - |
| 1.73e-29 | FFCP PHASE2:Mm9::chr18:60751417..60751432,-#_f047413b3e81d144b8b738936bf41e77 | p2@Myoz3 |
| 1.73e-29 | FFCP PHASE1:Mm9::chr18:60751417..60751432,-#_f047413b3e81d144b8b738936bf41e77 | p2@Myoz3 |
| 2.42e-29 | FFCP PHASE1:Mm9::chr11:67051354..67051366,+#_8e0ebfb3f7789fac255d6bcc748edafc | p2@Myh4 |
| 2.42e-29 | FFCP PHASE2:Mm9::chr11:67051354..67051366,+#_8e0ebfb3f7789fac255d6bcc748edafc | p2@Myh4 |
| 7.46e-29 | FFCP PHASE1:Mm9::chr1:57155729..57155740,-#_123d1ddda89f8c28788ede7d3d29eef0 | p@chr1:57155729..57155740, - |
| 7.46e-29 | FFCP PHASE2:Mm9::chr1:57155729..57155740,-#_123d1ddda89f8c28788ede7d3d29eef0 | p@chr1:57155729..57155740, - |
| 9.26e-29 | FFCP PHASE1:Mm9::chr4:43597258..43597265,-#_16eb028f96faa219760505baa946ca45 | p1@Msmp |
| 9.26e-29 | FFCP PHASE2:Mm9::chr11:67056544..67056589,-#_16eb028f96faa219760505baa946ca45 | p@chr11:67056544..67056589, - |
| 9.26e-29 | FFCP PHASE2:Mm9::chr4:43597258..43597265,-#_16eb028f96faa219760505baa946ca45 | p1@Msmp |
| 9.26e-29 | FFCP PHASE1:Mm9::chr11:67056544..67056589,-#_16eb028f96faa219760505baa946ca45 | p@chr11:67056544..67056589, - |
| 1.15e-28 | FFCP PHASE2:Mm9::chr6:90552017..90552024,+#_92a2588774fe437475f1a7ba4ad22a85 | p@chr6:90552017..90552024, + |
| 1.15e-28 | FFCP PHASE1:Mm9::chr6:90552017..90552024,+#_92a2588774fe437475f1a7ba4ad22a85 | p@chr6:90552017..90552024, + |
| 1.15e-28 | FFCP PHASE1:Mm9::chrY:2858251..2858257,+#_92a2588774fe437475f1a7ba4ad22a85 | p@chrY:2858251..2858257, + |
| 1.15e-28 | FFCP PHASE2:Mm9::chrY:2858251..2858257,+#_92a2588774fe437475f1a7ba4ad22a85 | p@chrY:2858251..2858257, + |
| 1.43e-28 | FFCP PHASE1:Mm9::chr6:34436258..34436292,+#_49bf9859c76fbacd91754191dd298cc0 | p@chr6:34436258..34436292, + |
| 1.43e-28 | FFCP PHASE2:Mm9::chr6:34436258..34436292,+#_49bf9859c76fbacd91754191dd298cc0 | p@chr6:34436258..34436292, + |
| 2.2e-28 | FFCP PHASE2:Mm9::chr11:67069796..67069817,-#_7375fc6e720e0530282ef79be22d41f9 | p@chr11:67069796..67069817, - |
| 2.2e-28 | FFCP PHASE1:Mm9::chr11:67069796..67069817,-#_7375fc6e720e0530282ef79be22d41f9 | p@chr11:67069796..67069817, - |
| 2.72e-28 | FFCP PHASE1:Mm9::chr8:107702369..107702386,+#_fa981f2b7bb96f75c8bcf9a6d648844d | p@chr8:107702369..107702386, + |
| 2.72e-28 | FFCP PHASE2:Mm9::chr8:107702369..107702386,+#_fa981f2b7bb96f75c8bcf9a6d648844d | p@chr8:107702369..107702386, + |
| 3.45e-28 | FFCP PHASE1:Mm9::chr18:78254135..78254146,-#_cec68a25b8dcc36e329a627524cf1554 | p1@Siglec15 |
| 3.45e-28 | FFCP PHASE2:Mm9::chr18:78254135..78254146,-#_cec68a25b8dcc36e329a627524cf1554 | p1@Siglec15 |
| 6.5e-28 | FFCP PHASE2:Mm9::chr7:133591490..133591500,-#_fecc71f073e59576bbee3e293f8d65de | p6@Atp2a1 |
| 6.5e-28 | FFCP PHASE1:Mm9::chr7:133591490..133591500,-#_fecc71f073e59576bbee3e293f8d65de | p6@Atp2a1 |
| 8.9e-28 | FFCP PHASE2:Mm9::chr7:133591156..133591165,-#_488fb8000e9c9b309fd79c51d57279e3 | p7@Atp2a1 |
| 8.9e-28 | FFCP PHASE1:Mm9::chr7:133591156..133591165,-#_488fb8000e9c9b309fd79c51d57279e3 | p7@Atp2a1 |
| 1.42e-27 | FFCP PHASE2:Mm9::chr7:133592162..133592188,-#_8902fb09bb60da3548c30029cf104d36 | p@chr7:133592162..133592188, - |
| 1.42e-27 | FFCP PHASE1:Mm9::chr7:133592162..133592188,-#_8902fb09bb60da3548c30029cf104d36 | p@chr7:133592162..133592188, - |
| 1.42e-27 | FFCP PHASE2:Mm9::chr7:133600635..133600663,+#_8902fb09bb60da3548c30029cf104d36 | p@chr7:133600635..133600663, + |
| 1.42e-27 | FFCP PHASE1:Mm9::chr7:133600635..133600663,+#_8902fb09bb60da3548c30029cf104d36 | p@chr7:133600635..133600663, + |
| 6.75e-27 | FFCP PHASE2:Mm9::chr11:94837662..94837673,-#_15e5553ecb13020abfb0b9f31eca853f | p4@Sgca |
| 6.75e-27 | FFCP PHASE1:Mm9::chr11:94837662..94837673,-#_15e5553ecb13020abfb0b9f31eca853f | p4@Sgca |
| 1.66e-26 | FFCP PHASE2:Mm9::chr5:104754379..104754387,+#_abee73d3e4faedb1478c04d281cc82e1 | p1@Mepe |
| 1.66e-26 | FFCP PHASE1:Mm9::chr5:104754379..104754387,+#_abee73d3e4faedb1478c04d281cc82e1 | p1@Mepe |
| 3.47e-26 | FFCP PHASE2:Mm9::chr12:81581216..81581231,+#_c3bcb94c9808b6afd62d93bfc3a1ceb2 | p@chr12:81581216..81581231, + |
| 3.47e-26 | FFCP PHASE1:Mm9::chr12:81581216..81581231,+#_c3bcb94c9808b6afd62d93bfc3a1ceb2 | p@chr12:81581216..81581231, + |
| 3.47e-26 | FFCP PHASE2:Mm9::chr16:32400888..32400899,+#_c3bcb94c9808b6afd62d93bfc3a1ceb2 | p2@Tm4sf19 |
| 3.47e-26 | FFCP PHASE1:Mm9::chr16:32400888..32400899,+#_c3bcb94c9808b6afd62d93bfc3a1ceb2 | p2@Tm4sf19 |
| 1.12e-25 | FFCP PHASE1:Mm9::chr15:97806574..97806585,-#_eb8d55927803e3d07ff74df67a5991ac | p@chr15:97806574..97806585, - |
| 1.12e-25 | FFCP PHASE2:Mm9::chr15:97806574..97806585,-#_eb8d55927803e3d07ff74df67a5991ac | p@chr15:97806574..97806585, - |
| 1.12e-25 | FFCP PHASE1:Mm9::chr17:34176173..34176200,+#_eb8d55927803e3d07ff74df67a5991ac | p5@Col11a2 |
| 1.12e-25 | FFCP PHASE2:Mm9::chr17:34176173..34176200,+#_eb8d55927803e3d07ff74df67a5991ac | p5@Col11a2 |
| 1.36e-25 | FFCP PHASE1:Mm9::chr2:180890942..180890956,-#_d45e42dbe01aa116aef2e4bb4c05443b | p@chr2:180890942..180890956, - |
| 1.36e-25 | FFCP PHASE1:Mm9::chr18:78254174..78254185,-#_d45e42dbe01aa116aef2e4bb4c05443b | p2@Siglec15 |
Property "Property value" (as page type) with input value "UBPROP:0000001 "Replacement bone that forms within cartilage.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "Replacement bone that forms within cartilage.[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "Replacement bone that forms within cartilage.[VSAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
