Coexpression cluster:C4441

Full id: C4441_Mesothelial_Mesenchymal_Lens_Fibroblast_mesenchymal_Retinal_mesothelioma

Phase1 CAGE Peaks

Hg19::chr4:90332350..90332360,+	p@chr4:90332350..90332360 +
Hg19::chrX:8472470..8472482,-	p@chrX:8472470..8472482 -
Hg19::chrX:8472595..8472610,-	p@chrX:8472595..8472610 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
smooth muscle cell of the umbilical artery	1.28e-10	4
muscle cell	5.12e-10	54
fibroblast of tunica adventitia of artery	1.86e-09	4
fibroblast of the aortic adventitia	1.86e-09	4
muscle precursor cell	2.97e-09	57
myoblast	2.97e-09	57
multi-potent skeletal muscle stem cell	2.97e-09	57
contractile cell	8.63e-09	59
electrically responsive cell	1.43e-08	60
electrically active cell	1.43e-08	60
smooth muscle cell	4.42e-08	42
smooth muscle myoblast	4.42e-08	42
mesodermal cell	4.87e-08	119
mesothelial cell	1.08e-07	19
vascular associated smooth muscle cell	4.46e-07	32
non-terminally differentiated cell	7.80e-07	180
cardiocyte	9.94e-07	16

Uber Anatomy

Ontology term	p-value	n
umbilical artery	1.28e-10	4
splanchnic layer of lateral plate mesoderm	2.40e-10	84
blood vessel	1.20e-09	60
epithelial tube open at both ends	1.20e-09	60
blood vasculature	1.20e-09	60
vascular cord	1.20e-09	60
artery wall	1.86e-09	4
tunica adventitia of artery	1.86e-09	4
adventitia	1.86e-09	4
tunica adventitia of blood vessel	1.86e-09	4
aorta tunica adventitia	1.86e-09	4
aorta wall	1.86e-09	4
artery	2.62e-09	42
arterial blood vessel	2.62e-09	42
arterial system	2.62e-09	42
skeletal muscle tissue	2.33e-08	61
striated muscle tissue	2.33e-08	61
myotome	2.33e-08	61
heart	2.59e-08	24
primitive heart tube	2.59e-08	24
primary heart field	2.59e-08	24
anterior lateral plate mesoderm	2.59e-08	24
heart tube	2.59e-08	24
heart primordium	2.59e-08	24
cardiac mesoderm	2.59e-08	24
cardiogenic plate	2.59e-08	24
heart rudiment	2.59e-08	24
muscle tissue	5.89e-08	63
musculature	5.89e-08	63
musculature of body	5.89e-08	63
vessel	8.69e-08	69
cardiovascular system	3.29e-07	110
primary circulatory organ	3.71e-07	27
epithelial tube	4.57e-07	118
vasculature	5.07e-07	79
vascular system	5.07e-07	79
circulatory system	7.28e-07	113
dermomyotome	9.67e-07	70

Disease

Ontology term	p-value	n
ovarian cancer	2.20e-13	14
reproductive organ cancer	8.65e-10	29
female reproductive organ cancer	6.06e-09	27

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.