MCL coexpression mm9:507

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127470688..127470731,+	p@chr10:127470688..127470731 +
Mm9::chr14:63585020..63585025,-	p@chr14:63585020..63585025 -
Mm9::chr14:63585028..63585037,-	p@chr14:63585028..63585037 -
Mm9::chr14:63585048..63585062,-	p@chr14:63585048..63585062 -
Mm9::chr15:37163047..37163087,-	p1@ENSMUST00000160264
Mm9::chr15:85476119..85476143,+	p2@uc007xdi.1
Mm9::chr18:44413512..44413521,-	p@chr18:44413512..44413521 -
Mm9::chr1:155964760..155964772,-	p1@uc007das.1
Mm9::chr3:146444177..146444215,-	p@chr3:146444177..146444215 -
Mm9::chr4:46614213..46614246,+	p@chr4:46614213..46614246 +
Mm9::chr4:61941433..61941455,+	p@chr4:61941433..61941455 +
Mm9::chr7:116781120..116781134,-	p@chr7:116781120..116781134 -
Mm9::chr7:135148666..135148682,-	p1@ENSMUST00000126205
Mm9::chrX:105011839..105011859,+	p2@Fam46d

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004691	cAMP-dependent protein kinase activity	0.00602640661809018
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.00602640661809018
GO:0005952	cAMP-dependent protein kinase complex	0.00903960992713527
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0271188297814058
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0271188297814058
GO:0019933	cAMP-mediated signaling	0.0271188297814058
GO:0019935	cyclic-nucleotide-mediated signaling	0.0271188297814058
GO:0019932	second-messenger-mediated signaling	0.0463280008765682

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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