MCL coexpression mm9:837

Phase1 CAGE Peaks

	Short description
Mm9::chr18:61204957..61204967,+	p4@Pdgfrb
Mm9::chr2:125127459..125127472,-	p@chr2:125127459..125127472 -
Mm9::chr8:11199340..11199353,-	p@chr8:11199340..11199353 -
Mm9::chr8:11219189..11219201,-	p@chr8:11219189..11219201 -
Mm9::chr8:11312731..11312758,-	p1@Col4a1
Mm9::chr8:11312869..11312887,+	p1@Col4a2
Mm9::chr8:11354301..11354323,-	p@chr8:11354301..11354323 -
Mm9::chr8:11448495..11448557,+	p@chr8:11448495..11448557 +
Mm9::chr8:11448969..11449001,+	p@chr8:11448969..11449001 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005201	extracellular matrix structural constituent	1.28016208344516e-05
GO:0044420	extracellular matrix part	1.2828163433318e-05
GO:0005587	collagen type IV	1.2828163433318e-05
GO:0030935	sheet-forming collagen	1.2828163433318e-05
GO:0005578	proteinaceous extracellular matrix	0.000231088263798871
GO:0030020	extracellular matrix structural constituent conferring tensile strength	0.000231088263798871
GO:0005581	collagen	0.000290155949761186
GO:0005604	basement membrane	0.000805297147187118
GO:0006817	phosphate transport	0.000836646297554101
GO:0044421	extracellular region part	0.00162256709454504
GO:0015698	inorganic anion transport	0.00299634711228363
GO:0006820	anion transport	0.00385854729848647
GO:0001527	microfibril	0.00800448178953245
GO:0043205	fibril	0.00891854667042571
GO:0005021	vascular endothelial growth factor receptor activity	0.0138687345289946
GO:0005615	extracellular space	0.0274070605332511
GO:0022610	biological adhesion	0.031419874086069
GO:0007155	cell adhesion	0.031419874086069
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	0.0371532336198108
GO:0006811	ion transport	0.0388729510970686
GO:0001932	regulation of protein amino acid phosphorylation	0.0414491607461372
GO:0033238	regulation of amine metabolic process	0.0414491607461372
GO:0006521	regulation of amino acid metabolic process	0.0414491607461372
GO:0018212	peptidyl-tyrosine modification	0.0414491607461372
GO:0042325	regulation of phosphorylation	0.0414491607461372
GO:0018108	peptidyl-tyrosine phosphorylation	0.0414491607461372
GO:0051174	regulation of phosphorus metabolic process	0.0414491607461372
GO:0019220	regulation of phosphate metabolic process	0.0414491607461372
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0442858686454993

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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