MCL coexpression mm9:1303

Phase1 CAGE Peaks

	Short description
Mm9::chr11:72080123..72080142,-	p2@Slc13a5
Mm9::chr15:18748419..18748446,+	p3@Cdh10
Mm9::chr15:18748455..18748481,+	p1@Cdh10
Mm9::chr15:18748708..18748717,+	p4@Cdh10
Mm9::chr15:18853092..18853096,+	p@chr15:18853092..18853096 +
Mm9::chr6:125095277..125095296,+	p3@Iffo1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015141	succinate transmembrane transporter activity	0.00160699774110706
GO:0015744	succinate transport	0.00160699774110706
GO:0006842	tricarboxylic acid transport	0.00160699774110706
GO:0015137	citrate transmembrane transporter activity	0.00160699774110706
GO:0015142	tricarboxylic acid transmembrane transporter activity	0.00160699774110706
GO:0015746	citrate transport	0.00160699774110706
GO:0005310	dicarboxylic acid transmembrane transporter activity	0.00602492081764192
GO:0006835	dicarboxylic acid transport	0.00602492081764192
GO:0046943	carboxylic acid transmembrane transporter activity	0.0240666654828289
GO:0005342	organic acid transmembrane transporter activity	0.0240666654828289
GO:0046942	carboxylic acid transport	0.0240666654828289
GO:0015849	organic acid transport	0.0240666654828289
GO:0031402	sodium ion binding	0.0288609803336571
GO:0007156	homophilic cell adhesion	0.0288609803336571
GO:0006814	sodium ion transport	0.0358882749621469
GO:0015293	symporter activity	0.0399306889399139
GO:0015291	secondary active transmembrane transporter activity	0.0471791609237227
GO:0031420	alkali metal ion binding	0.0471791609237227

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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