MCL coexpression mm9:1273

Phase1 CAGE Peaks

	Short description
Mm9::chr11:109797621..109797632,+	p1@ENSMUST00000149226
Mm9::chr14:56563373..56563406,-	p@chr14:56563373..56563406 -
Mm9::chr17:25482504..25482508,-	p1@Tpsab1
Mm9::chr17:25503225..25503257,+	p2@Tpsb2
Mm9::chr17:25503260..25503273,+	p1@Tpsb2
Mm9::chr3:20142072..20142086,-	p1@Cpa3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0030019	tryptase activity	1.4407761922396e-06
GO:0006508	proteolysis	2.30070746533166e-05
GO:0008233	peptidase activity	2.30070746533166e-05
GO:0004252	serine-type endopeptidase activity	3.37683257571474e-05
GO:0008236	serine-type peptidase activity	3.37683257571474e-05
GO:0017171	serine hydrolase activity	3.37683257571474e-05
GO:0004295	trypsin activity	9.55060518853957e-05
GO:0004175	endopeptidase activity	0.000236121822834236
GO:0005615	extracellular space	0.000601401670937641
GO:0016787	hydrolase activity	0.000612741725887718
GO:0044421	extracellular region part	0.000621078313701449
GO:0030271	chymase activity	0.000730473529465476
GO:0044267	cellular protein metabolic process	0.00125734602011386
GO:0044260	cellular macromolecule metabolic process	0.00125734602011386
GO:0019538	protein metabolic process	0.00130092818928695
GO:0004182	carboxypeptidase A activity	0.0142149937063408
GO:0004181	metallocarboxypeptidase activity	0.0154320219846152
GO:0043170	macromolecule metabolic process	0.0161077453899997
GO:0004180	carboxypeptidase activity	0.019311576952437
GO:0008235	metalloexopeptidase activity	0.0226911316367904
GO:0044238	primary metabolic process	0.0226911316367904
GO:0008201	heparin binding	0.0226911316367904
GO:0044237	cellular metabolic process	0.0226911316367904
GO:0005539	glycosaminoglycan binding	0.0268657992678773
GO:0030247	polysaccharide binding	0.0282146244840345
GO:0001871	pattern binding	0.0284598079152524
GO:0008238	exopeptidase activity	0.030285097985417

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}