MCL coexpression mm9:1557

Phase1 CAGE Peaks

	Short description
Mm9::chr11:16908650..16908690,-	p1@Plek
Mm9::chr3:109143621..109143633,+	p8@Vav3
Mm9::chr3:109143649..109143661,+	p4@Vav3
Mm9::chr3:109143672..109143705,+	p1@Vav3
Mm9::chr3:109143711..109143738,+	p3@Vav3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030676	Rac guanyl-nucleotide exchange factor activity	0.00854560379022112
GO:0006906	vesicle fusion	0.00854560379022112
GO:0043552	positive regulation of phosphoinositide 3-kinase activity	0.00854560379022112
GO:0043550	regulation of lipid kinase activity	0.00854560379022112
GO:0043551	regulation of phosphoinositide 3-kinase activity	0.00854560379022112
GO:0005154	epidermal growth factor receptor binding	0.00996932479428507
GO:0045785	positive regulation of cell adhesion	0.014646796983947
GO:0030032	lamellipodium biogenesis	0.0160186172417038
GO:0006944	membrane fusion	0.0208795244679757
GO:0007242	intracellular signaling cascade	0.0226924411442025
GO:0019992	diacylglycerol binding	0.0314652936105574
GO:0030155	regulation of cell adhesion	0.0314652936105574
GO:0030031	cell projection biogenesis	0.0314652936105574
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0314652936105574
GO:0035023	regulation of Rho protein signal transduction	0.0314652936105574
GO:0005088	Ras guanyl-nucleotide exchange factor activity	0.0314652936105574
GO:0043087	regulation of GTPase activity	0.0321196813119172
GO:0007266	Rho protein signal transduction	0.0369436987527164
GO:0033674	positive regulation of kinase activity	0.0369436987527164
GO:0051347	positive regulation of transferase activity	0.0369436987527164
GO:0007229	integrin-mediated signaling pathway	0.0369436987527164
GO:0046578	regulation of Ras protein signal transduction	0.0387425536716064
GO:0051336	regulation of hydrolase activity	0.0403833373613207
GO:0005085	guanyl-nucleotide exchange factor activity	0.0410552713598788
GO:0051056	regulation of small GTPase mediated signal transduction	0.0410552713598788
GO:0043549	regulation of kinase activity	0.0410552713598788
GO:0043085	positive regulation of catalytic activity	0.0410552713598788
GO:0051338	regulation of transferase activity	0.0410552713598788
GO:0007265	Ras protein signal transduction	0.0428408209211364
GO:0005083	small GTPase regulator activity	0.0428408209211364

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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