MCL coexpression mm9:2592

Phase1 CAGE Peaks

	Short description
Mm9::chr10:84039628..84039649,+	p1@Tcp11l2
Mm9::chr6:134870669..134870693,+	p3@Cdkn1b
Mm9::chr6:134870706..134870722,+	p5@Cdkn1b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031116	positive regulation of microtubule polymerization	0.00276666849285049
GO:0031112	positive regulation of microtubule polymerization or depolymerization	0.00276666849285049
GO:0031113	regulation of microtubule polymerization	0.00368889132380065
GO:0046785	microtubule polymerization	0.00415000273927573
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	0.00442666958856079
GO:0051130	positive regulation of cellular component organization and biogenesis	0.00474286027345798
GO:0050680	negative regulation of epithelial cell proliferation	0.00474286027345798
GO:0004861	cyclin-dependent protein kinase inhibitor activity	0.00553333698570098
GO:0000079	regulation of cyclin-dependent protein kinase activity	0.00676296742696787
GO:0031110	regulation of microtubule polymerization or depolymerization	0.00704242889089216
GO:0031109	microtubule polymerization or depolymerization	0.00704242889089216
GO:0051271	negative regulation of cell motility	0.00790476712242997
GO:0040013	negative regulation of locomotion	0.00790476712242997
GO:0004860	protein kinase inhibitor activity	0.00790476712242997
GO:0019210	kinase inhibitor activity	0.00811556091236144
GO:0050678	regulation of epithelial cell proliferation	0.00830000547855147
GO:0050673	epithelial cell proliferation	0.0100902027386312
GO:0006469	negative regulation of protein kinase activity	0.010276197259159
GO:0033673	negative regulation of kinase activity	0.010276197259159
GO:0051348	negative regulation of transferase activity	0.010276197259159
GO:0051258	protein polymerization	0.010276197259159
GO:0007050	cell cycle arrest	0.0113072538403455
GO:0043086	negative regulation of catalytic activity	0.0113072538403455
GO:0051128	regulation of cellular component organization and biogenesis	0.0124500082178272
GO:0051270	regulation of cell motility	0.012647627395888
GO:0019887	protein kinase regulator activity	0.012647627395888
GO:0040012	regulation of locomotion	0.012647627395888
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.012647627395888
GO:0048839	inner ear development	0.0133563306551403
GO:0019207	kinase regulator activity	0.0135656003520411
GO:0043583	ear development	0.0135656003520411
GO:0007605	sensory perception of sound	0.0159083438338903
GO:0050954	sensory perception of mechanical stimulus	0.0162646572003938
GO:0045786	negative regulation of progression through cell cycle	0.0186552504089347
GO:0008285	negative regulation of cell proliferation	0.0186552504089347
GO:0045859	regulation of protein kinase activity	0.0195203832551118
GO:0043549	regulation of kinase activity	0.0196579077123588
GO:0051338	regulation of transferase activity	0.0196579077123588
GO:0006813	potassium ion transport	0.0217077066362115
GO:0007017	microtubule-based process	0.0234508091298756
GO:0008284	positive regulation of cell proliferation	0.0234508091298756
GO:0000074	regulation of progression through cell cycle	0.0234508091298756
GO:0007423	sensory organ development	0.0239348995195438
GO:0004857	enzyme inhibitor activity	0.0259060777057819
GO:0050790	regulation of catalytic activity	0.0328311327818258
GO:0015672	monovalent inorganic cation transport	0.0344029212589235
GO:0065009	regulation of a molecular function	0.0358560236673424
GO:0042127	regulation of cell proliferation	0.0358560236673424
GO:0051674	localization of cell	0.0358560236673424
GO:0006928	cell motility	0.0358560236673424
GO:0005829	cytosol	0.036563422827083
GO:0051726	regulation of cell cycle	0.0372436143268335
GO:0030001	metal ion transport	0.0406126054233525
GO:0007010	cytoskeleton organization and biogenesis	0.0456500301320331
GO:0006812	cation transport	0.0456500301320331
GO:0008283	cell proliferation	0.0456500301320331

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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